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<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGI0</accession>
    <name>A0A401NGI0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007409">
        <property type="protein sequence ID" value="GCB59874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGI0"/>
    <dbReference type="STRING" id="75743.A0A401NGI0"/>
    <dbReference type="OMA" id="MTHETAD"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB59874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="127" mass="13968" checksum="109F3F74B0D2EA81" modified="2019-05-08" version="1" fragment="single">KKNGAMEPDDLRACLISMGFDLGEAEFARIMNLVDPNNTGLVSFQSFISFMTRETADTDTADQVVASFRILAGDKPYILVEELRRELPSEQAEYCIASMPPYRGPEAIPGALDYASFSTALYGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJC4</accession>
    <name>A0A401NJC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NHL repeat-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for normal embryonic development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002438">
        <property type="protein sequence ID" value="GCB60947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJC4"/>
    <dbReference type="STRING" id="75743.A0A401NJC4"/>
    <dbReference type="OMA" id="DMEWINT"/>
    <dbReference type="OrthoDB" id="273823at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03012">
        <property type="entry name" value="TlpA_like_DipZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000063">
        <property type="entry name" value="NHL repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000068">
        <property type="entry name" value="NHL repeat-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000108">
        <property type="entry name" value="NHL repeat-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="453"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="711" mass="77317" checksum="39FE00DB5021567A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK39</accession>
    <name>A0A401NK39_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dynein heavy chain ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0012880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006371">
        <property type="protein sequence ID" value="GCB61248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK39"/>
    <dbReference type="STRING" id="75743.A0A401NK39"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="14">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="135"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB61248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="53320" checksum="521DCE2CB315BBBB" modified="2019-05-08" version="1">MEAASALIDGLSGEKIRWTEQCKEFKAQITRLVGDVLLATGFLSYSGPFNQTFRDILLRVIWEAELQRRRIPYTDNLNIITFLVDQAMIGEWNLQGLPSDDLSVQNGIIVTKATRYPLLIDPQTQGKTWIKRKEKNNELQVKVGDKETDVMAGFMFYITTKLPNPAYTPEISAKTSIIDFTVTIKGLENQLLGRVILTEKQELEAERVQLIEEVTANKRKMKELENNLLFKLSTTKGSLVDDESLIGVLQTTKSTATEVSEKLHVAAETEIKINMAQEEYRPAATRGSILYFLITEMTIVNIMYQTSLAQFLKLFDLSMARSKKSPVASKRIRNIIDYLTYEVFKYSVRGLYENHKFLFTLLLPLKINLERGFIKYNEFQTLIKGGAALDLKASPQKPFRWILDMTWLNLVELSKLSQFAEILNQISKNEKVWKVWFDTDAPEEEIIPNGYNDSLDPFCKLLLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLH7</accession>
    <name>A0A401NLH7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0009388</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 24">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01003817">
        <property type="protein sequence ID" value="GCB61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NLH7"/>
    <dbReference type="OMA" id="WYNITLA"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd05738">
        <property type="entry name" value="IgI_2_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05739">
        <property type="entry name" value="IgI_3_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14627">
        <property type="entry name" value="R-PTP-S-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14625">
        <property type="entry name" value="R-PTPc-S-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000027">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000068">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000015">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000128">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000098">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="106"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="196"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="291"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="389"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="483"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="585"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="694"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="792"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1111"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="1286"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1398"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="1575"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1666" mass="187845" checksum="4F48A32EF1D73FBD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMI2</accession>
    <name>A0A401NMI2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007741">
        <property type="protein sequence ID" value="GCB62047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMI2"/>
    <dbReference type="STRING" id="75743.A0A401NMI2"/>
    <dbReference type="OMA" id="CMNPLEE"/>
    <dbReference type="OrthoDB" id="420032at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04028">
        <property type="entry name" value="C2B_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000001">
        <property type="entry name" value="Regulating synaptic membrane exocytosis 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF15">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="130"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="284" mass="31127" checksum="6597F83E90C869E3" modified="2019-05-08" version="1">MVRRGPDTGNAGLRMQRSPSRISLSASFEALAVYFPCMNSFDEDDGEAGGKKLRSTIQRSTETGLAVEMRNRMTRQPSRESADGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQMVGRQTLATPPMGDIQIGMMDKKGQLEVEVIRARGLVGKPGSKALPAPYVKVYLLENGICIAKKKTKVARKTLDPLYQQQLPFEDSPQGKVLQIIVWGDYGRMDHKSFMGVAQILLEELDLSNMVFGWYKLFPTSSLVDPTLAPLTRRASQSSLESSSGPSYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMM8</accession>
    <name>A0A401NMM8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005186">
        <property type="protein sequence ID" value="GCB62141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMM8"/>
    <dbReference type="STRING" id="75743.A0A401NMM8"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF5">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU301113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB62141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="443" mass="48657" checksum="9389EFBD1E74F14F" modified="2019-05-08" version="1">MGQTSVSSFNQPVTADGLEKYSVTNPEALPPVSGTPPLKRKSKLASIGNIFKPWKWRKKKTSEKFQETSALLERKISTRQSRNELIRRGVLKEIPDQDGNAETTFRNGHTMHAVPIRVEPAAESPTGADPTVSAPPTQESDKHCNVAKHSNPLMPPQSPSRPHSAMNTNQPQDLPGFPGTGDTLRNSAKHSDFPSQPPSLQSNQSDSVGPPAAIHPPPQPGDHEEKTKAETERSLMVDVQKVDQTDPSEQQNLEKEILQADPSQPSKPDVTDGEMEISQGQTEKELTVTAETQKGGRDEVGRREKSAASPLPKKSHVQLNNSTPVIIIPSPTYRDSPGIDSDSDKSLQDKNESDESDEDDECLNSGQDTKQFSAASYMWPYSFSQAINDTPTGTETLLYTANYEKVNNMKREKIPCAIHYSINLLTAVVKRTVGTEESIKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPX2</accession>
    <name>A0A401NPX2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007857">
        <property type="protein sequence ID" value="GCB62933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPX2"/>
    <dbReference type="STRING" id="75743.A0A401NPX2"/>
    <dbReference type="OMA" id="SWYKMAG"/>
    <dbReference type="OrthoDB" id="9422899at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15193">
        <property type="entry name" value="CD83 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15193:SF1">
        <property type="entry name" value="CD83 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019033231" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="22025" checksum="4A2940B8804D53AF" modified="2019-05-08" version="1">MGRKTSHHSRHWFLSVQVLMVLGAECISEVAVKCGETARLPCKADFQVGLQYRAISWYKIIDNGVGLTGIVRKDFRENITRKYLGFNGPIELDSARPYCLIIHNVSREDFGTYQCSLWAPLGEQNKQADVGLREKDIRFERWWIIVPLVLMILVLIIFIGIYARKYNGPSDYKKCNNELTSSIGTLPGAENNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQQ6</accession>
    <name>A0A401NQQ6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0009630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003985">
        <property type="protein sequence ID" value="GCB63195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQQ6"/>
    <dbReference type="STRING" id="75743.A0A401NQQ6"/>
    <dbReference type="OMA" id="HHPFASI"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006700">
        <property type="term" value="P:C21-steroid hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071375">
        <property type="term" value="P:cellular response to peptide hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034650">
        <property type="term" value="P:cortisol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006704">
        <property type="term" value="P:glucocorticoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF123">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 27 SUBFAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="300" mass="34231" checksum="E63450D972669B62" modified="2019-05-08" version="1">MGCLEDDIPEETQRFIEAVFEVFRLSAIVIFFPKAMWPFLSQWKQFVAAWDYLFYITEKLVNKKIKETNERIEKGCSVEGEYLTYLLTSTKMTPVDIYGSLCELLLAAVDTTSNTTSWILYNLAREPSIQQELYEEVNSACPGDQIPAVKDFARMPLLKAVAKETLRMYPVVTGNARLIVEKDVVVGGYHFPKNTLFHLCHYAVSQDDSEFAEPQSFQPHRWLRGGGETKHHPFASIPFGFGTRICLGKRVAELEMYSVVTRLIKHFEVRPDPSGVTVMSKTRTLLSPASPINLEFIDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRY9</accession>
    <name>A0A401NRY9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0011650</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005364">
        <property type="protein sequence ID" value="GCB63612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRY9"/>
    <dbReference type="STRING" id="75743.A0A401NRY9"/>
    <dbReference type="OMA" id="IWEVVEM"/>
    <dbReference type="OrthoDB" id="6425912at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="183"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1185"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB63612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="141699" checksum="3A054FEF5D92825A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTK3</accession>
    <name>A0A401NTK3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0000247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000045">
        <property type="protein sequence ID" value="GCB64206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTK3"/>
    <dbReference type="STRING" id="75743.A0A401NTK3"/>
    <dbReference type="OrthoDB" id="9383028at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF52">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB64206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9596" checksum="899F4A68EB2F1822" modified="2019-05-08" version="1">MSIRESEERNRIQIVFQSFALEEEYDYLALYDGQPHPANFRTRLTGFQMPAPVTSTGSVFALRLTSDFAVSAHGFKLFYQGKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUC3</accession>
    <name>A0A401NUC3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0004611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001371">
        <property type="protein sequence ID" value="GCB64457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUC3"/>
    <dbReference type="STRING" id="75743.A0A401NUC3"/>
    <dbReference type="OMA" id="CNIFLMQ"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="100"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="392" mass="44271" checksum="F6A7CED322614F21" modified="2019-05-08" version="1" fragment="single">KTVVGVAQEANAKNKRDVESDNPDDVLFGKKPKLEAVTTEELNLTDLMPKVKVEQVDTVEGCNHEVAIPMCDEYQQLKPRVGKAAKEYPFILDAFQREAIACIDNNQSVLVSAHTSAGKTVCAEYAIALALRDKQRVIFTSPIKALSNQKYRELYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDAERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDPKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMSKLDFNTGRISLCSFRPLCKDAAKSRLCNIFLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUG0</accession>
    <name>A0A401NUG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative elongation factor B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006779">
        <property type="protein sequence ID" value="GCB64528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUG0"/>
    <dbReference type="STRING" id="75743.A0A401NUG0"/>
    <dbReference type="OMA" id="VRQQIWL"/>
    <dbReference type="OrthoDB" id="5548359at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010405">
        <property type="entry name" value="COBRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503:SF3">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06209">
        <property type="entry name" value="COBRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65727" checksum="22ED24C99C1037DB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUQ1</accession>
    <name>A0A401NUQ1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005471">
        <property type="protein sequence ID" value="GCB64589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUQ1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB64589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8605" checksum="35F7874F82FA2CAD" modified="2019-05-08" version="1">MSFPYTSVWSLPQQFWNSRPCRFAALLNIDHVQAVTREKRQMKCSQASANVALSKRAVLKNDSDFRKLWWEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUS2</accession>
    <name>A0A401NUS2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004120">
        <property type="protein sequence ID" value="GCB64600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUS2"/>
    <dbReference type="STRING" id="75743.A0A401NUS2"/>
    <dbReference type="OMA" id="PMHQQQX"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22478">
        <property type="entry name" value="KH-I_FUBP1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22481">
        <property type="entry name" value="KH-I_FUBP1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22484">
        <property type="entry name" value="KH-I_FUBP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22487">
        <property type="entry name" value="KH-I_FUBP1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000007">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000008">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000010">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015096">
        <property type="entry name" value="FUBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048249">
        <property type="entry name" value="KH-I_FUBP1_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048250">
        <property type="entry name" value="KH-I_FUBP1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048251">
        <property type="entry name" value="KH-I_FUBP1_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048252">
        <property type="entry name" value="KH-I_FUBP1_dom4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09005">
        <property type="entry name" value="FUBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="201"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="293"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="396"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="698" mass="72733" checksum="D02EEE986D96C907" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVF5</accession>
    <name>A0A401NVF5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Helicase POLQ-like</fullName>
            <ecNumber evidence="15">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Mus308-like helicase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">POLQ-like helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0014815</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01008103">
        <property type="protein sequence ID" value="GCB64834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVF5"/>
    <dbReference type="STRING" id="75743.A0A401NVF5"/>
    <dbReference type="OMA" id="YCRDFRP"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000002">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001293">
        <property type="entry name" value="helicase POLQ-like isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000058">
        <property type="entry name" value="Helicase, POLQ like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="305"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="525"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB64834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115232" checksum="425F9C782D0C33E4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVK7</accession>
    <name>A0A401NVK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Paired box protein Pax-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0000340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000064">
        <property type="protein sequence ID" value="GCB64884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVK7"/>
    <dbReference type="STRING" id="75743.A0A401NVK7"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="13">
        <location>
            <begin position="54"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="224"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB64884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48670" checksum="26C164B7840DD91B" modified="2019-05-08" version="1">MKNRNYYLNRTNKTLIQWLLPAFKGELSVGKTTDPRKQLGKSGVHPPENMSYKGVGCVNQLGGVFVNGRPLPTCKRKRIIEMATGGIRACDISRILQVSNGCVSKILGRFYQTGSVGPKAIGGSKPRLSTPEVVAKITQFKWNNPSMFAWEIRGKLLSEGVCTRDKIPSVSSINRVLRNLHPDLQISASVNTTRNQWTGDFAERDTNETLTNLPSDFVEDVRPNCQQRNRTVYTQGQAEELEKEFRRSQYPDVFAREKLASKISLPEARIRVWFSNRRAKWRREEKAKSRSGFLNGSTCGLMLNQLQASPHGFPTYHPSPMIDSMSLQPHQPQTVQTNHVFLIPETLKPHGYDLCRVAESRLRMNPTTEAWKMHGFDLYRTLESPPCLGPGPTFTSDMSNGRAVIGSRETSGAAELLGATGELDYKCLKRTIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVQ9</accession>
    <name>A0A401NVQ9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable ATP-dependent RNA helicase DHX35</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DEAH box protein 35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0000348</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May be involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01000066">
        <property type="protein sequence ID" value="GCB64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVQ9"/>
    <dbReference type="STRING" id="75743.A0A401NVQ9"/>
    <dbReference type="OMA" id="FERPTHA"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17980">
        <property type="entry name" value="DEXHc_DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000007">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="64"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="261"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB64963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="701" mass="78667" checksum="DA0D065E462F7F72" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXG0</accession>
    <name>A0A401NXG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PABC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002859">
        <property type="protein sequence ID" value="GCB65557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXG0"/>
    <dbReference type="STRING" id="75743.A0A401NXG0"/>
    <dbReference type="OMA" id="SRIYPKH"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PABC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="3">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="3">
        <location>
            <begin position="222"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB65557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="298" mass="33200" checksum="34258AD4E1A27335" modified="2019-05-08" version="1">MEQQNTRGETLYNAIFPQHPELAIKLTGMLLELPVPVLDQMMQDEKLLSAGLQKALNTLQDSTEKWQDINKCLFEFVQGDVDSDSTDSLGDQLYDLVDIHNTGHSEKITGMLLEMGQNEVKKLVSDLQLLEQRIQIAQDALELKMSDERKMSNSSDFDDAKEKLGEKVFEQIEKIDPQNCACITGMVLELDPSAIQMLLTDRLALHIAVEKAQAVLSQSATPNSGLANDEDGSELDTESEKIGEELYCYVSNTKYSEHASRITGMLLEMPHSRLAELLKSPEELNGKIEIAASALKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYK7</accession>
    <name>A0A401NYK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0000514</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000095">
        <property type="protein sequence ID" value="GCB65957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYK7"/>
    <dbReference type="STRING" id="75743.A0A401NYK7"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF236">
        <property type="entry name" value="PROTOCADHERIN GAMMA-C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="133"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="242"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="358"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="455"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="579"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB65957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="797" mass="86885" checksum="D0B171287F7454E1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYN3</accession>
    <name>A0A401NYN3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA adenine methylase transferase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005614">
        <property type="protein sequence ID" value="GCB65979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYN3"/>
    <dbReference type="STRING" id="75743.A0A401NYN3"/>
    <dbReference type="OrthoDB" id="9894200at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071253">
        <property type="term" value="F:connexin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042998">
        <property type="term" value="P:positive regulation of Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042318">
        <property type="entry name" value="Consortin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028129">
        <property type="entry name" value="Consortin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054132">
        <property type="entry name" value="Consortin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28581">
        <property type="entry name" value="CONSORTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28581:SF1">
        <property type="entry name" value="CONSORTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15281">
        <property type="entry name" value="Consortin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22883">
        <property type="entry name" value="Consortin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="7">
        <location>
            <begin position="133"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB65979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121130" checksum="84D2D903C434777C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYS5</accession>
    <name>A0A401NYS5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ryanodine receptor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0014941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008233">
        <property type="protein sequence ID" value="GCB66000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYS5"/>
    <dbReference type="STRING" id="75743.A0A401NYS5"/>
    <dbReference type="OMA" id="QQFRVRH"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000006">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF9">
        <property type="entry name" value="RYANODINE RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="2" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIR" evidence="8">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="8">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="8">
        <location>
            <begin position="258"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="567"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB66000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="108101" checksum="A5D42E4D4AABBE4C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZU4</accession>
    <name>A0A401NZU4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004285">
        <property type="protein sequence ID" value="GCB66408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZU4"/>
    <dbReference type="OMA" id="THIDFQW"/>
    <dbReference type="OrthoDB" id="6508505at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="225" mass="25743" checksum="059B52CA9D4EDF0D" modified="2019-05-08" version="1">MGKTQYAQRFQTRIRERCTNFVVELVKQLRQRLPDNVGVLQSVSLLSVSECLKPIKPDIIELSKLFVGDDPSYLTHIDFQWKKIHHTKWSETGNTLHFWAEIANYRDSSGENPYKELSEVALTALALPHSNADVEHCFSHMNLIKYKLRNRMKTSILNEIMSVKYGLKRNDKCCATNELPTNVVKKIGTMEAYDSSSATRGQLIHDQATCSSAADMEEDWDAFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0K9</accession>
    <name>A0A401P0K9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008323">
        <property type="protein sequence ID" value="GCB66692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0K9"/>
    <dbReference type="STRING" id="75743.A0A401P0K9"/>
    <dbReference type="OMA" id="SIQEIAM"/>
    <dbReference type="OrthoDB" id="166212at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF41">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="105"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="330" mass="37567" checksum="905BF23795122960" modified="2019-05-08" version="1">MMYLDKTERGYQKFQRIAKIVKTICGINLVLKGYIQKAKVIRWVAYHLTRQLDLGKELLFNIHNFTKNKSERDSAKLNCLLSVPPHLRSIQEIAMVQSLLRKNQAFRCLPHIVQLEVCRVAVYQQYEAKTMVVRKGHQPEACYFLLTGELVATSSDSCSENQNHLTEVLNEIQEGDLFGDAALLTNTKRPATILCKTNAELLLINKEDFESVLAGFLQQRYHAVTDLLRSLPIFAPWTPEKLTLLSYSCLLRYYRSGTAVVPESSSSSFIVVVKSGRCDIVTNLRMDRHGIGLSQSSQQKKQTMIPKNLSLLEENTKLSEKSPQSKRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P287</accession>
    <name>A0A401P287_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit TOM70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0012119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005752">
        <property type="protein sequence ID" value="GCB67241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P287"/>
    <dbReference type="STRING" id="75743.A0A401P287"/>
    <dbReference type="OMA" id="AYFRRAC"/>
    <dbReference type="OrthoDB" id="66418at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB67241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52329" checksum="BC5FC2C95523E8B0" modified="2019-05-08" version="1">MAALKPVESQSGSGLSRWQLAVAIGAPLLLGAGAVYLWNKRTVSKRSERKAPEGSSSPVPKEEGGRGENESEGLSLLDRAQSAKNKGNKFFKAGKFEQAIQCYTEAISLCPLNQKQDLSTFYQNRAAAFEQLVWSTLPSNCVDVTAVCILEGFQNQQSMLLADRVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFNSFTDDIISQPLLKGENPDEDKDKEGEAADIRGTERSGYQKAKQYMEEENYDKIISECTKEIETKGKYVAEALLLRATFYLLIGNATAAQPDLDMVVSMKDANVKLRANALIKRGSMYMQQQQSQLSTQDFNMAADIDPQNADVYHHRGQLKILLDNVEEAVDDFDECIRLRPDSALAQAQKCFALLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNLAKAIEMFSKAINLAKSEMEMAHLYSLCDAAYAQTEVAKKYGLKPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3D7</accession>
    <name>A0A401P3D7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005791">
        <property type="protein sequence ID" value="GCB67627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3D7"/>
    <dbReference type="STRING" id="75743.A0A401P3D7"/>
    <dbReference type="OMA" id="ECYATAI"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14936" checksum="260A158015FAEA23" modified="2019-05-08" version="1" fragment="single">RYTQSNGRRPFGISALIVGFDYDGTPRLYQTDPSGTYQAWKANAIGRSAKTVREFLEKNYTDEAIATDNDTIKLAIKALLEVVQSGGKNIELAIIRRNQPLKLLDAKEIEHLVAEIEKEKEEETEKKKPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3W5</accession>
    <name>A0A401P3W5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 24 25">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="14 24 25">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">scyTo_0015161</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77126"/>
            <dbReference type="ChEBI" id="CHEBI:85351"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:45657"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45672"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77128"/>
            <dbReference type="ChEBI" id="CHEBI:85355"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:45673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:45677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:72864"/>
            <dbReference type="ChEBI" id="CHEBI:85350"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:45653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45668"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77130"/>
            <dbReference type="ChEBI" id="CHEBI:85354"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:45669"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:85349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:45649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45660"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77098"/>
            <dbReference type="ChEBI" id="CHEBI:85352"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:45661"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45664"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74560"/>
            <dbReference type="ChEBI" id="CHEBI:85353"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:45665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16230"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 24 25">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 24 25">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="14 24 25"/>
    <dbReference type="EMBL" id="BFAA01008460">
        <property type="protein sequence ID" value="GCB67824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3W5"/>
    <dbReference type="STRING" id="75743.A0A401P3W5"/>
    <dbReference type="OMA" id="FVIESTM"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF4">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 24" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20 24" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="18 24 25" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22 24" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="23 24" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 24 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="17 24 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00000859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00001617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00001729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00001902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GCB67824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="435" mass="50060" checksum="935C900315720A7C" modified="2019-05-08" version="1">MTELRRRGHEEEESLDEREPEPTPSGSEAKHDSGNLDPASVDNTPEVLNKALSGLSSRWKNWWVRGILTLAMISFFFLIIYLGPMVLMMIVMGVQIKCFHEIILIGYSVYHSYHLPWFRTLSWYFLLCANYFFYGETVTDTFFALVQREEPLRILSKYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLIIHNLFDGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVLFGALLSYVMSGYKYFVCPFEFNSDANSFTVDCEPSELFQLQDYTIPCLFQSFLGWETVRLYPFQIHSIALSTFASLISPFGGFFASGFKRAFKIKDFADTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPAKLLQQLLALRIDQQLQIFKSLKASLIQKGVLPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5Y9</accession>
    <name>A0A401P5Y9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0010415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004484">
        <property type="protein sequence ID" value="GCB68545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5Y9"/>
    <dbReference type="STRING" id="75743.A0A401P5Y9"/>
    <dbReference type="OMA" id="PCLGLQW"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058766">
        <property type="entry name" value="HHH_XRCC3_RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26169">
        <property type="entry name" value="HHH_XRCC3_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="59"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB68545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="335" mass="36691" checksum="6F17510C9B0A3B52" modified="2019-05-08" version="1" fragment="single">NIQSIKEILCLSGPDLQRLTKLSSSDVRYLHKTVAAVVKNDPVVTALQMYNEECPFPTQNRKLSMGCPVLDLLLGGGIPLMGITEIVGESSAGKTQICMQLCLSVQFPRSYGGQEAGAVYICTEDTFPNKRLQQLIALQTMLRADVPADIVNDIKFGNNIFIEHVADVESLNCCISKRLPILLSRGLIRLVVIDSVAALFRCEFGASDSIAKAKCLQKFGAMLHHLSHRFSSPIICVNQITDAINDSYLAQSDFGLSGKVLPALGLTWSNQLLMRLMVSRTQFCVEGAFPGDESALSSGIVQRRMEIIFAPHLPQSFCNYMICTEGVRGMQKTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P641</accession>
    <name>A0A401P641_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007237">
        <property type="protein sequence ID" value="GCB68595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P641"/>
    <dbReference type="STRING" id="75743.A0A401P641"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="25618" checksum="F458A95BD51B024D" modified="2019-05-08" version="1">MLAGCCLSVFQSWSFQVRYKLDGDKDPVFLSIDTRNWANGQLHSVKINREGKDIYIQIDQLAAVKYSLPSFTDLEFNTIKSLILGKIMGRKHCDADQEEYEAGLDHYEADREESETSQNHCEAEGEECEAGQKHCEADQEENEVGLDHYEADQEESEVGLDQYEAEWEESEVCLNHYEADRGESETSQNHCGAEWEECETGQDHCETNQEESEAGLDHCEADWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P646</accession>
    <name>A0A401P646_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Cholinergic receptor nicotinic alpha 1 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0010419</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Pentamer of two alpha chains, and one each of the beta, delta, and gamma chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004487">
        <property type="protein sequence ID" value="GCB68573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P646"/>
    <dbReference type="STRING" id="75743.A0A401P646"/>
    <dbReference type="OMA" id="CHVSSAW"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19014">
        <property type="entry name" value="LGIC_ECD_nAChR_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000013">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000016">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000019">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="23">
        <location>
            <begin position="68"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="24">
        <location>
            <begin position="282"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB68573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="27">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="57046" checksum="C3CA5117236ABDA6" modified="2019-05-08" version="1" fragment="single">VRKSLSPHPQKSRGASKSQRNVLEETDWVDRSIAPLESRRMVSCTDPHVALTILLFSCGGLVLASEHETRLVAKLFKNYNKVIRPVESHNQSVNITVGLQLIQLINVDEVNQIVETNVRLKQQWIDVKLRWKPADYGGIKKIRVPSSDIWLPDIVLYNNADGDFAIVHMTKVLLDYTGKVIWTPPAIYKSYCEIIVTHFPFDQQNCSIKLGIWTYDGTRVAIFPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFVMQRLPLYFVVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKVFIDTIPSVMFFSTMKRVTKEKPEKRIFTEDIDISDISGKQASGNIIFQTPLTKNPDVKSAIEGIKYIAEHMKSDQESNNAADEWKYVAMVIDHILLGVFMLVCIIGTLSVFAGRLIELNQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P795</accession>
    <name>A0A401P795_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005942">
        <property type="protein sequence ID" value="GCB68996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P795"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="56" mass="6613" checksum="2E3953484702EEB7" modified="2019-05-08" version="1" fragment="single">MTIITRTSCQPATYCSTHHLAVFWKLDPLVAHCKQTKEFLISNHLRLWHCPFNKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7X3</accession>
    <name>A0A401P7X3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0010529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004561">
        <property type="protein sequence ID" value="GCB69261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401P7X3"/>
    <dbReference type="OMA" id="XAISAGH"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02904">
        <property type="entry name" value="Macro_H2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000013">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000002">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035796">
        <property type="entry name" value="Macro_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Macro" evidence="11">
        <location>
            <begin position="261"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="446" mass="47621" checksum="30243D15C260F499" modified="2019-05-08" version="1">MKMEVGDEEHVATEEEEDKDEEEDEEEGDGAKDDDEALDLQGLEDKPREEPKAQPEAAEQAAAETYCSCVIVFVIIMSSRGGKKKTTKISRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAIANDEELNQLLKGVTIASGGVLPNIHPELLSKKRGSKGKLEAIITAPPAKKAKSSQSAKKTGGKKGKKGAGKGGAKKKQTEVSKAASADSTTEGNPGDTFTILSTKSLFLGQKLQVVQADIATIDSDVIVHPTNSDLYTGGEVGNALEKKGGKEFTEAVNELRKKNGPLDTAGAVLSSGHGLPAKFVIHCNSPGWGSDKCEELLEKTVKNCLALADEKKLKSIAFPSIGSGRNGFPKQSAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7Z5</accession>
    <name>A0A401P7Z5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0010528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004560">
        <property type="protein sequence ID" value="GCB69255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7Z5"/>
    <dbReference type="STRING" id="75743.A0A401P7Z5"/>
    <dbReference type="OMA" id="EITEHAN"/>
    <dbReference type="OrthoDB" id="10063284at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB69255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33631" checksum="235F13A5B94A2AD7" modified="2019-05-08" version="1">MGILQSLKYTFEDSEEKPECKRDAKNLYHKLVKLEYAILTVIWEEVLEHSNKTSKKLQTPGFDVFEDYLLLSSFLSFVKELRENSANRIAHYESEAKGLCEDITSSYSDASKHIVTRKFSDGTSGIPSLRGTHKFRIEVLYQLYDCLIIQLRKRIGSYEQIAKRFKFLSELVNNYQIDEDSIKLIISYYKDDIDHKLVNECYQFKEYVHLRKSQHTEENTPSEMKCAEVLQLICEQRLIEVFPNITTALKLNMTMPITSCEAERNFSKLSFIKNKFWSTMTEECLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8D5</accession>
    <name>A0A401P8D5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-like protein 7A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007336">
        <property type="protein sequence ID" value="GCB69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8D5"/>
    <dbReference type="STRING" id="75743.A0A401P8D5"/>
    <dbReference type="OMA" id="HATERMD"/>
    <dbReference type="OrthoDB" id="9932367at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50014" checksum="ACB5B5124E4FE7CC" modified="2019-05-08" version="1">MPWAQRPQPGAVTKLRPPSSGRQTRPACSERLQEAREMLQKIQRPPSRTVDKTKISRPPSLSGTTKDVKAKEKPDCEPQLPRVAVMKTGALVVDIGSGTCKVGYAGDPLPQSLIGSVVGYPRGKSKRNTVAVGRMSSEPDLKLVRPTRQGVIVDWAAAEELLRHVFYEDLKVSPEERAVLISDPPLSPTTNREKIAELLFERFNVPAMYISYQSVLAVYSYGKTTGLVVDSGDGVTHSVPVHEGYNLPDSISRIDLGGHDLTTYLIKLLSEAGNAFHEKGRYIVEDIKQKCCYVAVDQDKESTLSDQEYLVDYELPDGHVITIGKERMKCPEALFKPQVLGSNQEGIHTMTIRSLKKTQPHVQQLMYDNVLLCGGSTMFEGFYSRFCREIFALVPKDTKTNVHAVPERKFAVWIGGSLLASLHAFQSLWVLQDDYKERGPFIVHRRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8I0</accession>
    <name>A0A401P8I0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0008385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003199">
        <property type="protein sequence ID" value="GCB69447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8I0"/>
    <dbReference type="STRING" id="75743.A0A401P8I0"/>
    <dbReference type="OMA" id="IEYCEPE"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032924">
        <property type="term" value="P:activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10985">
        <property type="entry name" value="MH2_SMAD_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF25">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="205" mass="23073" checksum="88A20B8AC0134B2E" modified="2019-05-08" version="1" fragment="single">LQPVTYCEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPAIRCSSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P965</accession>
    <name>A0A401P965_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004614">
        <property type="protein sequence ID" value="GCB69701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P965"/>
    <dbReference type="STRING" id="75743.A0A401P965"/>
    <dbReference type="OMA" id="HRFIAGN"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23021">
        <property type="entry name" value="zf-HIT_IN80B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="3">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="319" mass="36080" checksum="08035CF4CEB727A6" modified="2019-05-08" version="1">MKEIKVVERQKDEAGGHSSHKKKHKKHKKHKKKHHQADVGLGFSSETLESDSGTGKPQLKLKIKLGGQTMGTKSVPHFSLTSELKQSPSPLTVDDEPDEVPLDQYRAWLDEESNLDPSPLPDLDSETLQVPEQDEEQRWLDALEKGELDDNGELKKEINESLLTARQRALLHKQQSQPLLELPMGYKAKEMTEEMMVKRAERARKRRLQAAKKAEDSKNQTIERLTKTNKAKVKTLRERRTKRVHYPMIRYSNNAIGITVSFPHGCAVPLPAISQPVPTPVTCGIEGCSNFKKYSCSKTGLPLCSFECYKKNLLIRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9L2</accession>
    <name>A0A401P9L2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004624">
        <property type="protein sequence ID" value="GCB69792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9L2"/>
    <dbReference type="STRING" id="75743.A0A401P9L2"/>
    <dbReference type="OrthoDB" id="9428789at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33072" checksum="81848074EE0D4472" modified="2019-05-08" version="1">MGSLLAAWVKNVNNINVVKVGHKQVVSMIRQGGNNLLMKVVTVSRKPELEDGMRKKDESLTSTSTESLEGLINIFKDDDASEENGDKSDQEESATTPPDPESEHHTCDCAVDWQEDLAQDPTPVAGSSKGPLLDCAMQAGGSTMEDQGTQQPQLRDTVPETSPAHTQQMLEQTIHLLHEAVQNFHVTVQSGYTQMHSDMTRSHTIMQFGWAQFTEQVGCLVSLLKTLVRDHQASTPQLRDVAVQSSLKSPEGQSAGVVLPTASSPVADVLPNTQCNPVGDHLNDGSSQSSVTCPVNRTHVHSFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9P6</accession>
    <name>A0A401P9P6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0012496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006051">
        <property type="protein sequence ID" value="GCB69838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9P6"/>
    <dbReference type="STRING" id="75743.A0A401P9P6"/>
    <dbReference type="OMA" id="WERCESX"/>
    <dbReference type="OrthoDB" id="6103117at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07699">
        <property type="entry name" value="IgC1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000283">
        <property type="entry name" value="Immunoglobulin kappa constant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019301005" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="240" mass="25788" checksum="9C328081C50CB48D" modified="2019-05-08" version="1">MCEWLRVLMALVLCLQSTNAGHVLTQPPSISTSLGKTVTITCTLSGGSMNNYYTSWYWQKPGSAPVFVCRDYDSSRGPGIPVRFTGSRVTSTNVMHLTNSNVMAEDVADYYCGAWDINAGGFTFGKGSKLNLGAPLAPSVSVLPPSPVQIKGKNTATLVCFLNGFKPGVADIEWTVDGSIRGNGVETSRIQQEADNTFSVSSYLTLSAAEWNSHELYSCVVKHEALANPLKTSISRSSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAE9</accession>
    <name>A0A401PAE9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Transcription elongation factor A (SII), 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0012546</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006084">
        <property type="protein sequence ID" value="GCB70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAE9"/>
    <dbReference type="STRING" id="75743.A0A401PAE9"/>
    <dbReference type="OMA" id="FQKTDMK"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000002">
        <property type="entry name" value="Transcription elongation factor A (SII), 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF50">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR A PROTEIN 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="16">
        <location>
            <begin position="72"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="17">
        <location>
            <begin position="241"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="360"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="157"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45333" checksum="0B6D03080AA2C4F7" modified="2019-05-08" version="1">MLRRVSGTRLFLPGSAPLTLVKHFFKFFFKNVLLCSRSFTFISCDLTFWAFFCCCCCCVRTDVGQAAMGREENLVGIAKRLDKMVSRKSLDGALDLLQELQGVKMTLKLLQSTRIGMSVNAMRKHSTDEEVTTLAKILIKNWKKLLASEIPVVQKTEKVEGKEGEKKDKSAPQQHSKEEYVERRNSSSSMSLMTLSPSSRKNSTEAEESGGGSKGKMESPSSPTFSTPTILPPFLSTGVSIRDKCIEMMIAALKTDDDYKDYGANCDKMGAEIEDYIYQEFQKTDMKYKNRVRSRISNLKDPKNPNLRKNVLAGAIDLLHLARMTAEEMASDELKELRNVITKEAIREHQMAKTGGTHSSLFQCGKCRKKNCTYNQVQTRSADEPMTTFVLCNECGNRWKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB04</accession>
    <name>A0A401PB04_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003295">
        <property type="protein sequence ID" value="GCB70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB04"/>
    <dbReference type="STRING" id="75743.A0A401PB04"/>
    <dbReference type="OMA" id="VFCGGWL"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046624">
        <property type="term" value="F:sphingolipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003376">
        <property type="term" value="P:sphingosine-1-phosphate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF4">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE TRANSPORTER SPNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="499" mass="54513" checksum="D28AF1F678565ABB" modified="2019-05-08" version="1">MADGVLADIQRHFGVSDSKSGLLPTVFICSFMVATPIFGFLGDRFNRKFILSCGIFFWSAVTLISSFITKPNFWLFLISRGLVGFGEASYSTIAPPIIADMFTKDTRTCMLSFFYFAIPLGSGLGYILGSCVTQASGDWHWALRVTPAMGFAAGTLIILLVPEPKRGAAEQHMVQLRASTSWSKDMKAVVKIPSFVFSTLASASVSFATGVLGMWIPLYLFRAEVVQKNIEPCTVEPCSGRDSLIFGAITCVTGFLGLIVGVAATRWYRTKSSRADPLVCAFGMLSSSIFISLIFVFARFNIVGAYMCIFIGETLLFLNWAITADILMYVVIPTRRSTAVALQSFTSHLLGDAGSPYLIGVISDVIRQRPKQSSSASGRDEAGFCESLRRAEVEAGEKGASHQLSPSNSSAVYPHHVTGPSDCRGSGEPPKESWERHNFQTGLNNKEPLLYRDATLHSLFIMEISVEEQSLKHLRLSLVPFPPQSTPSAHGEMHLCVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB43</accession>
    <name>A0A401PB43_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mab-21-like nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003301">
        <property type="protein sequence ID" value="GCB70329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB43"/>
    <dbReference type="STRING" id="75743.A0A401PB43"/>
    <dbReference type="OrthoDB" id="6054650at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061501">
        <property type="term" value="F:2',3'-cyclic GMP-AMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071360">
        <property type="term" value="P:cellular response to exogenous dsRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038001">
        <property type="term" value="P:paracrine signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF35">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="258"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="336" mass="35531" checksum="B969EFBD4706F3CC" modified="2019-05-08" version="1" fragment="single">MSQRKARSEAGAGGPVAKPKGAAPAAAVPANGPSAKRPGSSRAAGANPKGHLGKGSKERPRQNSCTNGEDSKSQSSPADPSRKSDDNHKEGIRRKNQVTGSSRTAGDQGTRTSRTAGDQGTRTSRAAGDQGTRTSRAAGDQGTRTSRAAGDQGTRAAGDQGTRAAGDQVTRAAGDQGTRTAGDQGTRSSRALGISSSEKDRNLNKVLRNVVEDLRIRSDQRSRASKVVNEVVDHLLRSIRKDSAGGFAAIEKLASGSYYENVKISEPNEFDIMTTIRVDRINLTDMDSKGAFYQVAFKRNQGTNPLRQFVCDGTLSAEKMIGHLRKLIKEAVKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDE5</accession>
    <name>A0A401PDE5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001890">
        <property type="protein sequence ID" value="GCB71147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDE5"/>
    <dbReference type="STRING" id="75743.A0A401PDE5"/>
    <dbReference type="OMA" id="DAPECSE"/>
    <dbReference type="OrthoDB" id="263617at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
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        <property type="term" value="F:ribonucleoprotein complex binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SECISBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284">
        <property type="entry name" value="GH01354P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284:SF10">
        <property type="entry name" value="SELENOCYSTEINE INSERTION SEQUENCE-BINDING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="281" mass="30661" checksum="8AC6D03F0A72F7C8" modified="2019-05-08" version="1" fragment="single">SLFNKLVALTEEARKAYRDMVTALEQEQAEEALKHTRKVPHMGHSRNPSAASAISFCSVISEPISEVNEKEYETNWRNMVEATDAPECSESEKSTPSATTVMDKSSSLPAVIGSANKPILITSPSAGQTALAAKASSSDKEEGKTDDILEWASQQSTETGSLDGSCRDVLNSSMISTTSTLVPDMLEEEEDDDDDDDEEEEDEDYTPDPVAIVVTFSSRIDDWVSEAQKTLETLQLGKNIDSTEEDHNGQSDIEELDTVEQMDATTESEGSQPAESESQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFD8</accession>
    <name>A0A401PFD8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0006083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001989">
        <property type="protein sequence ID" value="GCB71831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PFD8"/>
    <dbReference type="OMA" id="KFSEHIR"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
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        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF14">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="265"/>
            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="442"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
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        </location>
    </feature>
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            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
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        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB71831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57182" checksum="0BFCC944F63396B5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG69</accession>
    <name>A0A401PG69_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0006168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002032">
        <property type="protein sequence ID" value="GCB72098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG69"/>
    <dbReference type="STRING" id="75743.A0A401PG69"/>
    <dbReference type="OrthoDB" id="8921877at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin heavy constant gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="193"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB72098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="329" mass="36347" checksum="154CFD6EB0CD0633" modified="2019-05-08" version="1">MRWGYVPTNSSNIKWLVSLSPGSTDFSRIPGIEPRFSGTSESKLTLKIDSLNQTDSTDYYCQSVVDNGDDWCGCGLTLKVKPAITPRPPSVYLLHPSTEKMSQQTDSKLVCVVNDFYPETVTVSWYMGSTQLSSGISNSGILMESEGSYTIISELAVSTFQWVSGLRYTCVVSHKSLSSPIRKVVNIDDPIPPSIYVLPPTFEEIDVKKTSTIVCLAVGFYPESIFFRWLVNSQVKAASRSQTLPSVLNTNGSYTSRSGILGIMAPLWIVAVVGGLLLIIAAVILIHKKTTSSSRSETADFRETLNLEPRQESVYQNVYYKVFGQKPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG95</accession>
    <name>A0A401PG95_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase-like protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0001844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000428">
        <property type="protein sequence ID" value="GCB72141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG95"/>
    <dbReference type="STRING" id="75743.A0A401PG95"/>
    <dbReference type="OMA" id="WYERINI"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB72141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33525" checksum="05D7FE92DC0E7F92" modified="2019-05-08" version="1" fragment="single">VPKVTHTEFCQGRTMRWALAWSFYEDVIMPSPPSKKRKLEKPRKPITFTILESTIKELKNKVASSDPVPTEDIEVATTAIEKILAELKVLCKRVPCGKGEVSLFLTAIQNSWVHVRRKKRDRVRQLRELPRATSVVLKSTEADQTTEKQCNANTGSARAEEESDLSSSAESNAKTGKAAVGAKEEIPVNGGNNLLNKLHVDQENNMETEEKCNQCETSFADCKTDDAVEQEICSSTMANPEGEDTTEESGSFLFKCLMNVKKDGKNAHVEMHWVEGQNRDLMNQLSTYLRNQMFKLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHT5</accession>
    <name>A0A401PHT5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 35 member F5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002153">
        <property type="protein sequence ID" value="GCB72658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHT5"/>
    <dbReference type="STRING" id="75743.A0A401PHT5"/>
    <dbReference type="OMA" id="MYGVYTI"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="283"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB72658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="481" mass="54599" checksum="F6758DF0290F449A" modified="2019-05-08" version="1">MKKYLRLQMVWLFIMNRMSSQSSSLQRRRMILGIIILLIVDIIWVVSSELTSYIFKKYEKPFFSTFAKTSMFVLYLIGFLVWKPWREQCTNGRRVALFADAESYLATCTTDNSVNDSLSEPLYIPVKFHDSANEKANNDNTTALKKTRVRFSNIMEVRQLPAHHAFEAKLSRMSYPAAKDHEAVLKSVGKLTVSQVAKISFFFCFVWFLANFSYQEALSDTQVAVVNILSSTSGLFTLLLAAMFPSNSGDRFTLSKLLAVVLSIGGVTLVSLSSNDTEGKGTIGSLWSLTGAVLYAIYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEAFEFPTKTVWMYILINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSMIADIYLKKVEFSWLLFAGSVPVFLSFFIATLLCHYNNWDPVMVGLRRIFAFICRKHRIQRTPEDSEQCESLIPMHGVSQEEGTNCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI42</accession>
    <name>A0A401PI42_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0006476</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002189">
        <property type="protein sequence ID" value="GCB72797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI42"/>
    <dbReference type="STRING" id="75743.A0A401PI42"/>
    <dbReference type="OMA" id="AKNCGIN"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05591">
        <property type="entry name" value="STKc_nPKC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000126">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034669">
        <property type="entry name" value="nPKC_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="133"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="394"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB72797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="462" mass="52220" checksum="B341FD9FAB69F055" modified="2019-05-08" version="1" fragment="single">VCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRKKKLNTGQDPQQSIPGAAPPEEDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHKVAGADKQAVTPGENGELKPFQTRHYNLEDFSFIKVLGKGSFGKVMLAELKGSDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLFCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHQNGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGITTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKSPNKRLGCVTSQGGEEAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDDAIVKQINQDEFKGFSYFGEESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJS3</accession>
    <name>A0A401PJS3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0006738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002323">
        <property type="protein sequence ID" value="GCB73365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJS3"/>
    <dbReference type="STRING" id="75743.A0A401PJS3"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008373">
        <property type="term" value="F:sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF37">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-BETA-1,4-GALACTOSIDE ALPHA-2,3-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB73365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28295" checksum="5B26B1F4C6B6AB47" modified="2019-05-08" version="1" fragment="single">MNDYRIHLDLLIIVNPSKLEYDRLGFLLKLDSRMELENPVVDNRGDGCAYADAHKDRLFIPCHPTLGYIRSTELNYKNGNITEGGCRKGFASAQMTEIFPKFSKPAPMFLDNTYKRWMKLKDFVPPFGIKGQEAVIQKILGITKHYTLTSYLDSLSCKRCIIMGNGGIVANKSLGSRIDDYDVVIRLNEAPVKGFEKDVGAKTTLRITYPEGAIQKPARYEKDSLFVFAGFKPQDFKWLKYIVYKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJY7</accession>
    <name>A0A401PJY7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0002549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000644">
        <property type="protein sequence ID" value="GCB73447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PJY7"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007616">
        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF158">
        <property type="entry name" value="PLATELET GLYCOPROTEIN IB ALPHA CHAIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019542695" description="LRRCT domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="7">
        <location>
            <begin position="202"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="7">
        <location>
            <begin position="855"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1395"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1876"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB73447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1952" mass="214523" checksum="D35B33E05E0C51ED" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK83</accession>
    <name>A0A401PK83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integrator complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0002590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000658">
        <property type="protein sequence ID" value="GCB73511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK83"/>
    <dbReference type="STRING" id="75743.A0A401PK83"/>
    <dbReference type="OMA" id="QICSSCF"/>
    <dbReference type="OrthoDB" id="70899at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="74966" checksum="2D8E721EC95F60EF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN56</accession>
    <name>A0A401PN56_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cux N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0003658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001019">
        <property type="protein sequence ID" value="GCB74567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN56"/>
    <dbReference type="STRING" id="75743.A0A401PN56"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF5">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB74567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="22482" checksum="D42027E5870B381F" modified="2019-05-08" version="1">MAANVGSMFQYWKKFDLRRLQKELNSVASELAARQEESEQSHKHLIELSREFKRNVPEEIREMVAPLLKSFQVEVVALSKRSKEAEAAFLNVYKQLIEAPDPAPSLEAARNLEEKLLQLQRNEPESRIGKDFFRHCKKQSELLNCEATEQSAETSPASIKASEELQKSSTDSTALKNDNLSQKNEAEKERYMRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNN1</accession>
    <name>A0A401PNN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protein XRP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0003824</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NDK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001073">
        <property type="protein sequence ID" value="GCB74733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNN1"/>
    <dbReference type="STRING" id="75743.A0A401PNN1"/>
    <dbReference type="OMA" id="WEANLED"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990075">
        <property type="term" value="C:periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000004">
        <property type="entry name" value="Protein XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039093">
        <property type="entry name" value="XRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440:SF0">
        <property type="entry name" value="PROTEIN XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440">
        <property type="entry name" value="XRP2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037947">
        <property type="entry name" value="Protein_XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 12" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="17">
        <location>
            <begin position="31"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine" evidence="14">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="14">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037947-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037947-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB74733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="357" mass="40439" checksum="2B6432928A9DDE1B" modified="2019-05-08" version="1">MGCLFSRKSKEKNREKKKKNDKEEADGEEGPKQYSWDQREKVDVKDYMLVQLKDQTVGRLPGKVAGEQFVIQECENCNIYVFDHSATINIDDCTNCKIFLGPIKGSVFFRDCSDCKCVVACQQFRTRDCKKMDVFLCCATQPIIESSTGMKFGCFQYYYPELGYQFKDAGLSIFNNNWSNIHDFTPVADENNWILLPEDAMPQDFVPLPDSEELKSVRISTEVNRSIVPVTRGQRQKNSEELCLVVFFAGDYTTANARKLIDEMALKDFALVQTKEISMRPDDANRVFKEKAADFIPFLQQGPVIALEFNGDGAVEACQNIVSSVFSASKVFVSESKASASQDVDNFYNYADIQMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNN4</accession>
    <name>A0A401PNN4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0003825</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001073">
        <property type="protein sequence ID" value="GCB74734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNN4"/>
    <dbReference type="STRING" id="75743.A0A401PNN4"/>
    <dbReference type="OMA" id="NEHCWQY"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF62">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="16">
        <location>
            <begin position="86"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="652"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB74734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="708" mass="78791" checksum="51C2B1FEAF8AD6CC" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP00</accession>
    <name>A0A401PP00_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017404">
        <property type="protein sequence ID" value="GCB74839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP00"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="100" mass="11019" checksum="9EB1FE29C8C450CA" modified="2019-05-08" version="1" fragment="single">MRRRAALRRTQEVPTSEQCDRASVGALNPPQCTEGTQDEGTTAEQIPEERKVNEPGLQPTEGENETQAKGKNQEVPTRENCDRASVGALNPPQCTERTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPV1</accession>
    <name>A0A401PPV1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016280">
        <property type="protein sequence ID" value="GCB75176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPV1"/>
    <dbReference type="STRING" id="75743.A0A401PPV1"/>
    <dbReference type="OMA" id="EKHDQSS"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11276" checksum="202C8B2E35C94D5F" modified="2019-05-08" version="1" fragment="single">GERCRKRRKVFCQITQHLLENHEMWKKVIEEEQRKAEFEKHDQSSQHQSSETIQAITEEEEDKEEKSNEGSEGKSNTPISLNSNTSNETLEDDKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ88</accession>
    <name>A0A401PQ88_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009884">
        <property type="protein sequence ID" value="GCB75280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ88"/>
    <dbReference type="STRING" id="75743.A0A401PQ88"/>
    <dbReference type="OMA" id="TTQYEEG"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070508">
        <property type="term" value="P:cholesterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010879">
        <property type="term" value="P:cholesterol transport involved in cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042555">
        <property type="entry name" value="StarD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47006">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47006:SF1">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="174" mass="19860" checksum="F82E9BB20A68FB24" modified="2019-05-08" version="1">MKDVTVWKKPSEEFGGFLYKTQGIVKEIPNRIVDYIRPGPYRLNWDSLMTSMDIIGEFEQQGCCLMHYTTAGQLWNVIAPREFIDFSFTTDYQNGLLSCGVSVEYGIEQPNFVRGFNHPCGWFCIPLKNDPDHSLLTGFIQTDLRGMLPQTVVGTAMANTLINFYNELRNALKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQV4</accession>
    <name>A0A401PQV4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013772">
        <property type="protein sequence ID" value="GCB75509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQV4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="10897" checksum="22D971F51DA69866" modified="2019-05-08" version="1">MTMASITFNHAIFNHVTDDHTMVYHLTLDCTALNLLIVNYVSTDYAKLDYETVNHVIFSCITVEHMAANHAILDHATINDMKVNDAKFNGTPLDTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRA1</accession>
    <name>A0A401PRA1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015106">
        <property type="protein sequence ID" value="GCB75654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRA1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="9862" checksum="46C84CBAA7DD2B22" modified="2019-05-08" version="1">MKNWGNKDWDNQDWGNKDWDNQDWDNKDWDNKDWDNKIWDNKNWDNKDWHKKDWDTKDWGQQGLGQQGLGQQELGQQELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT07</accession>
    <name>A0A401PT07_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011342">
        <property type="protein sequence ID" value="GCB76286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT07"/>
    <dbReference type="STRING" id="75743.A0A401PT07"/>
    <dbReference type="OrthoDB" id="9450321at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061689">
        <property type="term" value="C:tricellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060856">
        <property type="term" value="P:establishment of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904274">
        <property type="term" value="P:tricellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051874">
        <property type="entry name" value="Ig-like_domain-LISCH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15923:SF1">
        <property type="entry name" value="LIPOLYSIS-STIMULATED LIPOPROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15923">
        <property type="entry name" value="TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="223" mass="25893" checksum="D5B47F172830123A" modified="2019-05-08" version="1">MSEISSLHEDYDTRNNLHSNIGRVRQQAMPAIYDDDERSVMSSASRQTPRRDPRWDENDRYYEGSRQRARSMESLDDIGRRDRSYDRGHQGFDNSRVRRESDSEASSHRYAPDRRRRDYSPERHGEYRKRSRSRDDLTELDRGGRYPRGGYDDSFLGEVLAKKAGARREADSGSSSTARSRNRRDEDISLPPPSTETESVSSKGKNEKRLRKNDAVSRESLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU66</accession>
    <name>A0A401PU66_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017925">
        <property type="protein sequence ID" value="GCB76689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU66"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="22070" checksum="105DAD348FF9CB87" modified="2019-05-08" version="1">MAWVVVDSEGELITGEQILGNYSAQIAELIAFTKALEWGKGKRINVHADSRILLLAHFGAPLHLWLQPSISTTSPWTRKEPDIAETQTNDRMYTNVTRSITIGHHELTPYRDVSIVEAGDLGRSDEDQRTHRYVQKGLSRIPHLWADWEGLKKEAMQIDHLWNKERELIKTHAEKAEELFKSQNFFSRIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUE5</accession>
    <name>A0A401PUE5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DBIRD complex subunit ZNF326</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Zinc finger protein 326</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0015534</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008853">
        <property type="protein sequence ID" value="GCB76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUE5"/>
    <dbReference type="STRING" id="75743.A0A401PUE5"/>
    <dbReference type="OrthoDB" id="9904304at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044609">
        <property type="term" value="C:DBIRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007071">
        <property type="entry name" value="AKAP95"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034736">
        <property type="entry name" value="ZF_C2H2_AKAP95"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12190">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN AKAP 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12190:SF1">
        <property type="entry name" value="DBIRD COMPLEX SUBUNIT ZNF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04988">
        <property type="entry name" value="AKAP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51799">
        <property type="entry name" value="ZF_C2H2_AKAP95"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2 AKAP95-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2 AKAP95-type" evidence="13">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="524" mass="58855" checksum="57E99BB08CEDCE79" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVX3</accession>
    <name>A0A401PVX3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015466">
        <property type="protein sequence ID" value="GCB77258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVX3"/>
    <dbReference type="STRING" id="75743.A0A401PVX3"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8724" checksum="8F38CF04F51DD63A" modified="2019-05-08" version="1">MVRYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGVLYNCIIFILTRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWA3</accession>
    <name>A0A401PWA3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0019284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014183">
        <property type="protein sequence ID" value="GCB77434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWA3"/>
    <dbReference type="STRING" id="75743.A0A401PWA3"/>
    <dbReference type="OMA" id="WITHSSI"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF17">
        <property type="entry name" value="CARBOXYPEPTIDASE B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019224874" description="Peptidase M14 domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB77434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="278" mass="31916" checksum="E24EB8E96BF4337A" modified="2019-05-08" version="1">MFMRVERCLAMVVLHCQVLIDADTDCGIRLPWGTTNPREITNAYPSFIQKILIGPSSEKRLIYVLKLFNGTASPKGAVWIDCGIHAREWIAPAFCQWFVQYLIDSQDTMITDILKSFEIYILPIWNVDGYEYTWTTDRFWRKNLSKHHRGQCRGTDLNRNWDASWCGPGASNNPCSQTYCGRHPESEPEVKAVATFIRQRSDHIKGYISIHSYSQMVMFPYSYKTSKSKDHKELNYIAQKAVTAVRSVHGTNYRYGNSATSIWEGRAQLPGAAEDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWF9</accession>
    <name>A0A401PWF9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011583">
        <property type="protein sequence ID" value="GCB77466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWF9"/>
    <dbReference type="STRING" id="75743.A0A401PWF9"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:001037">
        <property type="entry name" value="Glutamate receptor ionotropic, delta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="122" mass="14278" checksum="943E440548FFB6D9" modified="2019-05-08" version="1" fragment="single">MLRLVNELRWQKFIVFYDSNYDIRGLQGFLDQASRQGLDVSLQRIDQNISRIFASLFTTMKTEELNRYRDTLRRAILLLSPRGAQTFINEVSDQHISKVDQRGEAGGELKRSNVCRYPNTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWJ6</accession>
    <name>A0A401PWJ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate [NMDA] receptor epsilon subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0020581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016828">
        <property type="protein sequence ID" value="GCB77495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWJ6"/>
    <dbReference type="STRING" id="75743.A0A401PWJ6"/>
    <dbReference type="OMA" id="EMPPNES"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018884">
        <property type="entry name" value="NMDAR2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10565">
        <property type="entry name" value="NMDAR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamate [NMDA] receptor epsilon subunit C-terminal" evidence="4">
        <location>
            <begin position="69"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB77495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="694" mass="79161" checksum="CA184C8F840BAFD4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYC5</accession>
    <name>A0A401PYC5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009095">
        <property type="protein sequence ID" value="GCB78043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYC5"/>
    <dbReference type="STRING" id="75743.A0A401PYC5"/>
    <dbReference type="OMA" id="PNVERHY"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="216" mass="24508" checksum="8E8623A024601D1D" modified="2019-05-08" version="1" fragment="single">DTGLRPSGAGGRAANASPKLLTSDRRWKRTILAAGASTVLGNVQEGPNVERHYLNQSGQQYYTPEVSAFDGPDDLLTQLESQIYGSSTELQTRTDFTLKSFQPKVQVPFYVPPGQRPRKLEIERRRRQYQNQNLKQLLKLEGINSDKLMPRHSGPERNRAKTGKNAPHFTVYLPLEVFDDEEFECRTPEEWLQLGYEEGSDIRKPIPAKALLPKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYT6</accession>
    <name>A0A401PYT6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01009140">
        <property type="protein sequence ID" value="GCB78295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYT6"/>
    <dbReference type="STRING" id="75743.A0A401PYT6"/>
    <dbReference type="OrthoDB" id="8954381at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047170">
        <property type="entry name" value="PTN12/18/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983:SF2">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983">
        <property type="entry name" value="TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="14314" checksum="7CC4274BFBBB3991" modified="2019-05-08" version="1" fragment="single">SGSKEDSPPPLPERTPESFVVANESDSLVRPVHVGKSAEWSGFPQATTVEQIKMVRSKSLKNPRSSRMNTPEILASGTPLGEKGLVTTATRGEVGQTSEANTKRRERGSDLGFNNRYTKPRGPRDPPPEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ39</accession>
    <name>A0A401PZ39_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009148">
        <property type="protein sequence ID" value="GCB78340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PZ39"/>
    <dbReference type="OMA" id="LQKCICY"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF29">
        <property type="entry name" value="NACHT AND WD REPEAT DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="161"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="4">
        <location>
            <begin position="393"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1431" mass="161575" checksum="44CBF4DB03DB88DC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ91</accession>
    <name>A0A401PZ91_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013120">
        <property type="protein sequence ID" value="GCB78455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ91"/>
    <dbReference type="STRING" id="75743.A0A401PZ91"/>
    <dbReference type="OrthoDB" id="6353782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="147"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB78455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="491" mass="54202" checksum="7BECFCEBA541721A" modified="2019-05-08" version="1">MEEPNQHFKSRLHFNSSTGSLMLNNLNQSDQGVYRIIVDDKLKWNTSVKLIEALSEPSITGNSTCVDTTIELTCRVSSGIASSILWWKDGKVIANDQRYQLMKSNSTLIISKAIKSDCGIYTCTMENPVSKKNALYSLTLYEALSEPSITGNSTCVDTTIELTCRVSSGIASSILWWKYGEVIANDQRFQLMESNSTLIISKAIKSDCGIYSCTMENPVSKKNASYSLALYGLTYIHHCTVAFSTAAFITALATLLTMVATFLDKIPCLNEDSRITFQFIQEKMQHFLEFSPVLSFIFLFVAYVCWIQTEVCHKMFNIGTSVTDIIATSILLAEVMGQSGSPGITRILSVLLCLHLIVTIFSTYNMMTCDRNMLSKILPTKLCHVILKVQAPLGGAIAISASLILIEEVMKQAGEKCEPAAFVLSTTCSAAVITLVILVATFVLYKIYSEWKQRTSGTPSEHTDCSKTPDECNPIELKKTLLNPGAPQLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ98</accession>
    <name>A0A401PZ98_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0019413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014417">
        <property type="protein sequence ID" value="GCB78452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ98"/>
    <dbReference type="STRING" id="75743.A0A401PZ98"/>
    <dbReference type="OMA" id="YPAYPLH"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
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    </dbReference>
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        <property type="entry name" value="TF_GATA-2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003027">
        <property type="entry name" value="TF_GATA-1/2/3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="280"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="334"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 1" evidence="11">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 2" evidence="11">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR003027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB78452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="468" mass="50542" checksum="B46AA8ECA88C9F5A" modified="2019-05-08" version="1">MMEVTAEQPRWMTHHHAVLNGPDTHHQALTHNYMEPTQLLPPDEVDVFFNHLDGQGNPVPSYYSNSPHARATVSYRQAHARLSGGQVCRPHLLHSPTISWLDSGKALSAAAAHHHHHNATAWAVNPFTKGPLHPAGASGITVYPGSGSASSLSAAAAAAHSSPHHLFSFPPTPPKDVSPDLGVHSSVSPSSSAAAAAGRQDDKESIKYHVSLAEGMKLECSRTNIPSLGASASSTHHPIPTYPYVHGAHEYSSSLFHPSGLLSASSNFTSKPRSKTRSCAAEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTSTTTLWRRNANGDPVCNACGLYFKLHNVNRPLTMKKEGIQTRNRKMSSKSKKNKRMSDGFEELSKCMQDKVSSFSLADHMQHMAHLPQFSHAGHVLPTPTPIHPSSSLSFAHPHPSSMVSAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZF4</accession>
    <name>A0A401PZF4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018354">
        <property type="protein sequence ID" value="GCB78413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZF4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14831" checksum="D00A2ED5666CAA79" modified="2019-05-08" version="1">MGEACDRGWEGKARDQGWEGEPCNRGWEGEARNLGWEGEACDQGWVGEASEGGARDQGWEGEACDWGWEGETCDQGWEGWVGETCDQGWEVEACDQGWEGESCDQDWEGEGEACDRGCDGEACDQGWAGEACCDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0J5</accession>
    <name>A0A401Q0J5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0018669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013216">
        <property type="protein sequence ID" value="GCB78886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0J5"/>
    <dbReference type="STRING" id="75743.A0A401Q0J5"/>
    <dbReference type="OMA" id="WQAHSAN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000007">
        <property type="entry name" value="Crystallin gamma N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF22">
        <property type="entry name" value="GAMMA-CRYSTALLIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB78886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="21848" checksum="9A7BD2023DE006A3" modified="2019-05-08" version="1">MSQYSGKIIFYEGKCFTGRKLEVCGDCDNFQDRGFMNRVNSIRVESSAWICYDHPDFKGHQYILERGEYPDFYRWNAHNDHMGSCRPVKMHGEHYRIELFENCDFKGQCMEFCEDCPFLQGRGWNKTCVNSLRVYGDGAWVLYDEPNYRGRMYIVERGYYHSHSEWQAQNGNIQSLRRVVNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1E8</accession>
    <name>A0A401Q1E8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.311</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA uridine(34) acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0015945</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="16"/>
    <dbReference type="EMBL" id="BFAA01009321">
        <property type="protein sequence ID" value="GCB79202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1E8"/>
    <dbReference type="STRING" id="75743.A0A401Q1E8"/>
    <dbReference type="OMA" id="CTEASFI"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="136"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB79202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="287" mass="32778" checksum="862F8AAA985DE760" modified="2019-05-08" version="1" fragment="single">GHTVRAVCESFQLAKDAGFKVVAHMMPDLPNVGLERDIEQFIEFFENPAFRPDGMKLYPTLVIRGTGLYELWKTGRYKSYSPSTLVDLVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDWGTECRDVRTREVGIQEIHHKVRPYQVELVRRDYVASGGWETFLSYEDPEQDILIGLLRLRKCSEETFRSELKGGVSIVRELHVYGSVVPVSGRDPSKFQHQGFGMLLMEEAERIAQEEHGSTKIAVISGVGTRNYYRKIGYELEGPYMVKCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3W7</accession>
    <name>A0A401Q3W7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0016107</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009523">
        <property type="protein sequence ID" value="GCB80119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3W7"/>
    <dbReference type="STRING" id="75743.A0A401Q3W7"/>
    <dbReference type="OMA" id="YPYIGWI"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF153">
        <property type="entry name" value="CYTOCHROME P450 2G1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB80119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45835" checksum="F773A0A6312FE641" modified="2019-05-08" version="1" fragment="single">LGEQYGPVFTIWLGSCPAVVLCGQEAVAEALIERGHDFSGRYVLPVFRKLANDYGIAFSNGERWKQLRRFTLSTLRNFGMGKKSIEERILEEAQFLVTAIRNKKDTPLNPNRLLRCAASNIICSIVFGERFDYEDKMFLTLMEMIAENIQNLNSPWIQLYNSFPTILDFLPGPHKKQFQNAADLLNFIKQMIQSHKESLQKDFPRDYIDSFLIKMEEEEHKHDSEFIHMNLLWTIMNLFLAGTETTSTTLQSAIRILAKYPHIQAVRTGNKGRSGELYSCISGSGEGGRGETEDMRGTCVVPLLSSVLKATSQWETPEAFNPNHFLCENGHFKKSESFMAFSAGKRICPGESLARMELFLFLTTLLQSFVFNPVIDRKNIDISPVISGFSVVPNDYEFYAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q412</accession>
    <name>A0A401Q412_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">KN motif and ankyrin repeat domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010814">
        <property type="protein sequence ID" value="GCB80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q412"/>
    <dbReference type="STRING" id="75743.A0A401Q412"/>
    <dbReference type="OMA" id="CKQQSFL"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047184">
        <property type="entry name" value="KANK1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021939">
        <property type="entry name" value="KN_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168:SF24">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12075">
        <property type="entry name" value="KN_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="719"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="84924" checksum="15A94BF5FD93AC39" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q472</accession>
    <name>A0A401Q472_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0016117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01009531">
        <property type="protein sequence ID" value="GCB80150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q472"/>
    <dbReference type="STRING" id="75743.A0A401Q472"/>
    <dbReference type="OMA" id="CDCAIDP"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19678">
        <property type="entry name" value="UBR-box_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047507">
        <property type="entry name" value="UBR-box_UBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="571" mass="65515" checksum="D9078A7B487B492F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
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        <name type="common">Cloudy catshark</name>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="CARMIL_C"/>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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            <end position="151"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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            <position position="1"/>
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        <source>
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    <sequence length="535" mass="58528" checksum="D28BCCA8A2AAE293" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
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            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
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        <location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8921" checksum="FC2760700D2C2CE8" modified="2019-05-08" version="1" fragment="single">HRRATHFSTEDLKSLGYHFCDTLLDFCDPDNSKFEQCLLDVRAALQRELRRRLEKLGRQYDSDVILSDLSMSDLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401Q835_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020250">
        <property type="protein sequence ID" value="GCB81532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q835"/>
    <dbReference type="STRING" id="75743.A0A401Q835"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="39" mass="4318" checksum="B66498550BAAD2E1" modified="2019-05-08" version="1" fragment="single">MGSVFRSEEMCLAQLFLQAASAYDCVSELGEDGLVEFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9X6</accession>
    <name>A0A401Q9X6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019318">
        <property type="protein sequence ID" value="GCB82172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9X6"/>
    <dbReference type="STRING" id="75743.A0A401Q9X6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="120" mass="13161" checksum="E093F6E897D92A3A" modified="2019-05-08" version="1" fragment="single">VIFSHLSSPSDVREALSVAAGALRGEVVTLVDQVGNPVGINPKMPANSERVLGINDFKEELSAKLDVLERRMDADRLRATEIARCTEDIKKLRLGYVCGCVTPASSKRLTPRRDIPTYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9X7</accession>
    <name>A0A401Q9X7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023288">
        <property type="protein sequence ID" value="GCB82188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9X7"/>
    <dbReference type="STRING" id="75743.A0A401Q9X7"/>
    <dbReference type="OMA" id="RENEECE"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052749">
        <property type="entry name" value="Alpha-tectorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025615">
        <property type="entry name" value="TILa_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160">
        <property type="entry name" value="ALPHA-TECTORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160:SF8">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12714">
        <property type="entry name" value="TILa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="306"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB82188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="428" mass="47785" checksum="A7E3A9A65C1F9695" modified="2019-05-08" version="1" fragment="single">VDDVRTSLPVTLVDGKLRLFQSGAYAVLETDFGLVVFYDWKWYLIVEIPSSYFGNLCGLCGNFNGTASDDKLFPNGTSVSSVVQWAGSWKVNDRDPFCWDYCRGYCPTCSDKHQNLYKSETYCGRLEKLFSGCHEKVDHKPFFDSCVYDVCLNQGRKSMLCQALAAYATECQREGITVTDWRKLASCPYECPANSHYSACGTACPPTCDDPKGVRSCPQRCVESCECDAGHVLLDSKCAPSSACGCSYQGIHYKPEERFWADNKCHVQCFCDPALRMVVCEERRCKSSEVCATVDGVRGCFPASYSTCSGSGDPHYKTFDGTRYNFMGTCVYKLSGLCSKASDLTPFEVQVQNNHRGSKAVSYTKKVTVQVYGVTIVLSVTEPHRVMVSVSSFLNLHISHCPFRKPQQTIQNKRGVQSTQIDIKKQNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB03</accession>
    <name>A0A401QB03_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022228">
        <property type="protein sequence ID" value="GCB82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB03"/>
    <dbReference type="STRING" id="75743.A0A401QB03"/>
    <dbReference type="OrthoDB" id="2115465at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033304">
        <property type="entry name" value="DLEC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348:SF1">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="301" mass="33404" checksum="3B956FDFDD251422" modified="2019-05-08" version="1" fragment="single">IRLDWETYNQEKEDLQLVDLIISYGQQFPVRDESGNEIIGTSIASSESEHSFDWDAIPNSRQSSSLALQTAECDVEEEEEEPEEEEKELPTNALISVVLRVHEGIAADYPYYLTPRQVVVPAGGVVTINVSFTPLTLTGVTTNVECEGFAFGHLSLDDQAAFGIPGKVTRSQGYNSEALRLDFRAVAKPALLSVAMDDDDEDLTFYAAASDLMAGGLECGIQREILTTRGLRLTNSTETPLYFQFLLHQPFCILNVEPKDNLKSSNSDREENMKMLVLHPLQHMHVSVGGLWRNGRSTAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB40</accession>
    <name>A0A401QB40_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023555">
        <property type="protein sequence ID" value="GCB82582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB40"/>
    <dbReference type="STRING" id="75743.A0A401QB40"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF4">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="85" mass="9539" checksum="0948D64921EBACF9" modified="2019-05-08" version="1">MPLREQEWLQILALIDPALGSPSRPVLVLCCVSTPDVARIPCVYVSHQLHLNQLDRPWLAHDTDAQSLGGFLEGIEWILQEVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCP0</accession>
    <name>A0A401QCP0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01031670">
        <property type="protein sequence ID" value="GCB83116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCP0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10264" checksum="02CFFDE8484B69F7" modified="2019-05-08" version="1" fragment="single">NMMSNLSQSKITMSVYPALKPCTVNTMAIHPKGLFTAGTDGTLYCIKVKPEKVEVEECWSAALPIRNIGFSRNYESLLIATDKVNQTQFQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD13</accession>
    <name>A0A401QD13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transmembrane ascorbate-dependent reductase CYB561</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome b-561</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome b561</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0023661</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>monodehydro-L-ascorbate radical(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + L-ascorbate(out)</text>
            <dbReference type="Rhea" id="RHEA:66524"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66525"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Secretory vesicle</location>
            <location evidence="12">Chromaffin granule membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01031985">
        <property type="protein sequence ID" value="GCB83271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD13"/>
    <dbReference type="STRING" id="75743.A0A401QD13"/>
    <dbReference type="OrthoDB" id="907479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF14">
        <property type="entry name" value="TRANSMEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYB561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="19">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB83271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7445" checksum="7DA8F231E36E3839" modified="2019-05-08" version="1" fragment="single">ILVYRVFKNESKTTVKILHGGIHLISLVATIVGLVSVFGYHSAQNIPDMYSLHSWCGLISIILFCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDE6</accession>
    <name>A0A401QDE6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034811">
        <property type="protein sequence ID" value="GCB83384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDE6"/>
    <dbReference type="STRING" id="75743.A0A401QDE6"/>
    <dbReference type="OMA" id="MGRDYYK"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000005">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF288">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="264" mass="30007" checksum="F0FA924A8CD0F0F6" modified="2019-05-08" version="1" fragment="single">MGKDYYIILGLQKGASEEEIKKAYRKQALKWHPDKNKSANAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGPDEQGGTFRYTFHGDPHATFAAFFGGANPFEMFFGRRMANGHQEEGMDVDSDPFAQFGGFSMNGFPRERHGGGMMGQMRRRQDPPIIHDLRVSLEEIYNGSTKRMKISRKRLNPDGRTVRTEDKILTIEIKKGWKEGTKITFPKEGDETPNTIPADVVFVLKDKLHSHFKRDGSNIVYHARVSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEM3</accession>
    <name>A0A401QEM3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01039583">
        <property type="protein sequence ID" value="GCB83821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEM3"/>
    <dbReference type="STRING" id="75743.A0A401QEM3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="12265" checksum="9089EF2FFCFCE25A" modified="2019-05-08" version="1" fragment="single">MAAYHRDRQQQEKLCNLEQRRKKLQLLLQEEQDLLEEELRELKMDAGSLIQDAKEKTEELKSAREERRRKKTMIHAKGSHDREESLVELQAQEGVHFCNSIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEY3</accession>
    <name>A0A401QEY3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01056166">
        <property type="protein sequence ID" value="GCB83877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEY3"/>
    <dbReference type="STRING" id="75743.A0A401QEY3"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="99" mass="11482" checksum="F5A12D74E7BF355F" modified="2019-05-08" version="1" fragment="single">KLASTIQQEAIKPIRQMLDEHTKRIKSSDSAVEKSSKLVTDNWSQQIKNKKKLMRSTKDHEAAFDLVENNKQIVSEKEKRKVVQTRVYKIANYRINAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF32</accession>
    <name>A0A401QF32_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0024835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01057987">
        <property type="protein sequence ID" value="GCB83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF32"/>
    <dbReference type="STRING" id="75743.A0A401QF32"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF11">
        <property type="entry name" value="CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7791" checksum="CC397B000C550BA0" modified="2019-05-08" version="1" fragment="single">WVMSKAKKEDADEDIAKYDGKWEVEEMKDTKLHGDMGLVLKSRAKHHAIAALFNRPFTFDNKPLFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHG9</accession>
    <name>A0A401QHG9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01106123">
        <property type="protein sequence ID" value="GCB84824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHG9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="36" mass="4080" checksum="11FEDA8A4C609A10" modified="2019-05-08" version="1" fragment="single">MQQRHNRQALKMVIVGDECCGKTCLQSVFTMGHCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHX3</accession>
    <name>A0A401QHX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lactase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01112766">
        <property type="protein sequence ID" value="GCB84960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHX3"/>
    <dbReference type="STRING" id="75743.A0A401QHX3"/>
    <dbReference type="OMA" id="SISWPRF"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000016">
        <property type="term" value="F:lactase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF38">
        <property type="entry name" value="LACTASE_PHLORIZIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11462" checksum="2D109E0133D65DD2" modified="2019-05-08" version="1" fragment="single">IEGAWRADGKGLSIWDTFTHTPLKVGNDDTGDVACDSYHKIDEDLAILKQLKVNHYRFSLSWSRILPDGTTGFVNEVGLNYYIKFIDALLAAQIKPQVHITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHX4</accession>
    <name>A0A401QHX4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01118500">
        <property type="protein sequence ID" value="GCB85011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHX4"/>
    <dbReference type="OMA" id="CSGQCRG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="156" mass="15082" checksum="5B0F93F2972E9849" modified="2019-05-08" version="1">MFLCKGQGEGQGEGQGEGQGQGKGQGQGEGQGEGEGQDGVQGEGHGEGEGQGEGEGEGEGEGEGQCEGQCEGQGESQGEGQCEGQCEGQCEGQGQDEGQGEDQGEGEGGGQGEGEGEGKGQGEGQGEGQGEGQDEGQGEGKGQGKGEDQGQGQGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI40</accession>
    <name>A0A401QI40_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01110571">
        <property type="protein sequence ID" value="GCB84997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI40"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="53" mass="5752" checksum="94205C9E81009EA3" modified="2019-05-08" version="1" fragment="single">HSNLLRPKSTLIPSLANRLLTIEEAQARSLAQGDEGTGAVYEQLRPIHTATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJD1</accession>
    <name>A0A401QJD1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01165465">
        <property type="protein sequence ID" value="GCB85468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QJD1"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="7935" checksum="2C8C43A3E0F17490" modified="2019-05-08" version="1" fragment="single">STVISTSMSNSHQLRPYTSVGEINHVHILSEHVGALIHHEEYSDVTFIVEKKRFSAHRVILAARCQYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJI7</accession>
    <name>A0A401QJI7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NUCB1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0026274</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01177388">
        <property type="protein sequence ID" value="GCB85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJI7"/>
    <dbReference type="STRING" id="75743.A0A401QJI7"/>
    <dbReference type="OMA" id="WTKGFIT"/>
    <dbReference type="OrthoDB" id="5982823at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057576">
        <property type="entry name" value="NUCB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25434">
        <property type="entry name" value="NUCB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NUCB1-like N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="9663" checksum="2476EFD0BD082D23" modified="2019-05-08" version="1" fragment="single">DTGLYYDRYLREVIDVLETDTHFREKLQTADVEDIKSGKLSSELDLVSHHIRTRLDELKRQEVSRLRMLIKAKMDAEQGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKT4</accession>
    <name>A0A401QKT4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01227036">
        <property type="protein sequence ID" value="GCB85974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKT4"/>
    <dbReference type="STRING" id="75743.A0A401QKT4"/>
    <dbReference type="OMA" id="EANKWAN"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="372" mass="41248" checksum="668B432D4E245DFF" modified="2019-05-08" version="1" fragment="single">QAVEEQAAEERAAEEQAVEEQAAEERAAEEQAAEEQAVEEQAAEERAAEEQAAEERAAEERAAEEQAVEEQAAEERAAEEQAVEEQAAEERAAEEQAVEEQAAEERAAEERVVEEQAVEEQAVEEQAADELALEEQAVEEQAVEERAAEEQAAEERAAEEQAVEERAAEEQAAEERAAEERAVEEQAAEERAAEEQAAEERAVEEQAVEEQAAEERAGEERAVEEQAVEEQAAEEQAAEERAAEEQAVEERAVEEQAAEEQAVEERAVEERAVEEQAAEERAAEERAAEEQAVEERAVEEQAAEDRAAEEQAAEERAAEERAVEERAVEERVAEERVVEEQAAEERAVEEQAVEERVAEERVVEEQAAEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL81</accession>
    <name>A0A401QL81_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01246015">
        <property type="protein sequence ID" value="GCB86145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL81"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="43" mass="4977" checksum="E958CD934C52E853" modified="2019-05-08" version="1" fragment="single">CYFSGDYKYEALCLTSEYPADLISEASRWVEIIQLDSADRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM31</accession>
    <name>A0A401QM31_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01293291">
        <property type="protein sequence ID" value="GCB86481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM31"/>
    <dbReference type="STRING" id="75743.A0A401QM31"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="57" mass="6313" checksum="CAB61DC6894C8A8D" modified="2019-05-08" version="1" fragment="single">EPVKSDEAKEMGSRINAFGYLECSAKTKEGVREVFELATRAALQAKKTKNKNPCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMK1</accession>
    <name>A0A401QMK1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01307143">
        <property type="protein sequence ID" value="GCB86528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMK1"/>
    <dbReference type="OMA" id="NTADHAS"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="22031" checksum="AAFAE474FFAE34F7" modified="2019-05-08" version="1">MRETETTRDRARDRARERERERERARKRDREREKERETERQSERQRDRARDRETERERDRERETERERQRERERETERHRETQSERDRERETEHKRQSERETERETEREREKQSERVRARVRDRARERETERERERQSERETEQERDRVRETVKVRQTERESEIESERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMK2</accession>
    <name>A0A401QMK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0027251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01312690">
        <property type="protein sequence ID" value="GCB86552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMK2"/>
    <dbReference type="STRING" id="75743.A0A401QMK2"/>
    <dbReference type="OMA" id="MSEQEHN"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB86552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="60" mass="6686" checksum="A2C7488EF91B76EF" modified="2019-05-08" version="1" fragment="single">MSEQEHNEKPVCDDDEEEKSLNYKPPAQKSLAEIASLDPDDESLAKYKKALLGEGLPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH95</accession>
    <name>A0A401NH95_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0006847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002377">
        <property type="protein sequence ID" value="GCB60241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH95"/>
    <dbReference type="STRING" id="75743.A0A401NH95"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1460.10:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1180:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF5">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="339" mass="39150" checksum="02153C95CE8EDF3A" modified="2019-05-08" version="1">MVGTLDVLVGLSDELAKLDSFVEGVVKKVAQYMADVLEDSRDKVQENLLASGVDLVTYITRFQWDMAKYPIKQSLKNISEIITKQVSQIDNDLKARASAYNNLKGNLQNLERKNVGSLMTRSLADIVKKEDFVMDSEYLTTLLVVVPKTGYLEWEKMYETLAEMVVPRSSKLICDDMDSGMYTVTLFRKAVDDFRLKARENKFIVRDFQYNEEELKADKEEMTRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKMMKKLREILNDLYKHLDSSAAAIIDAAMDIPGLSLSQQEYYPYVYYKIDCNLLEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJA8</accession>
    <name>A0A401NJA8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002441">
        <property type="protein sequence ID" value="GCB60981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJA8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="65" mass="7402" checksum="69DCF42075973E7D" modified="2019-05-08" version="1" fragment="single">GDCEWEKADWDWREESGGPPSPTPTTHTLERALTSKHVHTSIGANTYCGGELWNRLSMMTQWILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKR3</accession>
    <name>A0A401NKR3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein bL12m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">39S ribosomal protein L12, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0012922</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006398">
        <property type="protein sequence ID" value="GCB61468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKR3"/>
    <dbReference type="STRING" id="75743.A0A401NKR3"/>
    <dbReference type="OMA" id="DPTQHRS"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.710:FF:000006">
        <property type="entry name" value="39S ribosomal protein L12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="14">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="13">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB61468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="177" mass="19455" checksum="AB7140BF71D8C420" modified="2019-05-08" version="1">MGMVICRRELQTFCAWRALRASACNRCDALVTPPLDTAPKDYSPKIKQLVQEIASLTLLEIADLNELLKKTLKIQDIGMMPMAGAMAAAQTVFQAEDEEAPVKKEKTHFTVKLTEFKAAEKVKLIKEVKNCISGINLVQAKKLVESLPQEVKANVSKEEAEKLKSALEAAGGTVQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMG4</accession>
    <name>A0A401NMG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0009449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003859">
        <property type="protein sequence ID" value="GCB62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMG4"/>
    <dbReference type="STRING" id="75743.A0A401NMG4"/>
    <dbReference type="OMA" id="PYRNPEM"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19905">
        <property type="entry name" value="DSRM_ADAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044455">
        <property type="entry name" value="ADAD1_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF106">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="247"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="4">
        <location>
            <begin position="422"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="82232" checksum="E43B3901AAEB443B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMH5</accession>
    <name>A0A401NMH5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001226">
        <property type="protein sequence ID" value="GCB62091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMH5"/>
    <dbReference type="STRING" id="75743.A0A401NMH5"/>
    <dbReference type="OMA" id="KHRNSAY"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000003">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000009">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003949">
        <property type="entry name" value="K_chnl_volt-dep_EAG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF533">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01464">
        <property type="entry name" value="EAGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="77"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="209" mass="23607" checksum="BCD1002228E62604" modified="2019-05-08" version="1">MYANTNRYHEMVNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLAICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQMIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIHREALLKVLEFYTLFANSFSRNLILTCNLRKRELTLGASCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNS8</accession>
    <name>A0A401NNS8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>riboflavin(in) = riboflavin(out)</text>
            <dbReference type="Rhea" id="RHEA:35015"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the riboflavin transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005233">
        <property type="protein sequence ID" value="GCB62545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNS8"/>
    <dbReference type="STRING" id="75743.A0A401NNS8"/>
    <dbReference type="OMA" id="AYFWLAR"/>
    <dbReference type="OrthoDB" id="9995836at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009357">
        <property type="entry name" value="Riboflavin_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52, RIBOFLAVIN TRANSPORTER, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06237">
        <property type="entry name" value="SLC52_ribofla_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB62545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="476" mass="52355" checksum="7892CF6BD19D75F8" modified="2019-05-08" version="1">MSERGLSRCRRKQLITSIRPELPNANELCHIDEPAPQHHAPHHPRWGLPSYLTVIIQLANVGPLFVTLMHKFAPGKMNEIIVIYIIISIGIMASLLMIFFWKETTLLTGRPHSTAFLTLALFLSLVDCTSSVTFLPFMMRLPTKYMTTYFIGEGLSGFVPGLVALSQGVGMVKCVNVSKTINMTVDDFTEGSSIHQIETHYIPANFSTAAFLAFLTVMMVFCLVAFFFLTRVPWLPHKEINEAHVADQMVHVSTTESELNKHISKRPTNQQSSSPNSPTKSMDEAKLTAKTENVETSTFTKYSKQQHLFIYFLVAWVNSLTNGFLPSVQTYSCLPYGNLAYHLSAALGSMANPGACIIALILPKRSLVLLGSLSFVGTAFGAYNMAMAALSPCPLLQHSGAGAFLIIISWILFSGTLSYVKVMIGVIFRDESHSALVWCGAAVQLGSLIGTLTMFPLVSVYDIFKAGDSCKSNCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPJ9</accession>
    <name>A0A401NPJ9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0009583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01003941">
        <property type="protein sequence ID" value="GCB62810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPJ9"/>
    <dbReference type="STRING" id="75743.A0A401NPJ9"/>
    <dbReference type="OMA" id="CEPRGYI"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="77" mass="9570" checksum="D4162943FE991AFF" modified="2019-05-08" version="1">MDRNVNVYPSLCFPELYILKDGYKEFFQEFETFCEPRGYIQMHHKDYREELRSMRRKGRSVARYRRRKELFQTANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPP9</accession>
    <name>A0A401NPP9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp fold succinyl-CoA synthetase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0013124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006584">
        <property type="protein sequence ID" value="GCB62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPP9"/>
    <dbReference type="STRING" id="75743.A0A401NPP9"/>
    <dbReference type="OMA" id="DIAHESY"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000040">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="217" mass="23686" checksum="321400C5DFBBE0E9" modified="2019-05-08" version="1">MMATAVLRCRPLAALASRDGVRVFDVSSELLSIHGLQHIQQQQRNISLHEYISIGLLKEAGISVPEGKSVSTPEEAYSAAKAIGSKDLVVKAQILAGGRGKGTFEGGLKGGVKIVYSPEEARDITSKMIGKKLFTKQTGERGRMCNQVFVCERRYPRREYYFAITLERTFQGPVLIGSSEGGVNIEDVAAETPEAIITEPIDIIEGIKKEQTVKVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPT3</accession>
    <name>A0A401NPT3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase RNF220</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING finger protein 220</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase RNF220</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0000075</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with SIN3B. Interacts with CTNNB1 (via Armadillo repeats 2-8). Interacts with USP7 (via MATH domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01000012">
        <property type="protein sequence ID" value="GCB62874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPT3"/>
    <dbReference type="STRING" id="75743.A0A401NPT3"/>
    <dbReference type="OMA" id="YQRVHTN"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16563">
        <property type="entry name" value="RING-HC_RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000195">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040178">
        <property type="entry name" value="RNF220_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB62874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="325" mass="36399" checksum="F5F3BB226C961113" modified="2019-05-08" version="1">MPSNIDRLSHFNPAMDPAVMEDTEQTNGKEETFLRVRSNRQARLNARIGKNKRKKASEDGQVCPLCNETLSGSVEQMSRHVEACLDKRDGSYTNDDESVDIENESASGNRFEEYEWCGQKRIRATTLLEGGFRGSGFVTCSSKENHDSDADLDVDGDDTLEYGKPQYTEADIIPCTGEEPGEAKEREALRGAVLNGGTPSNRITPEFSKWASDEMPSTSNGESGKLEVQTQKTCKNSEIEKISEDATVTTIEALKARIRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITSPGDLRRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQG1</accession>
    <name>A0A401NQG1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNA-binding protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RNA-binding motif protein 28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0007344</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Nucleolar component of the spliceosomal ribonucleoprotein complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with U1, U2, U4, U5, and U6 spliceosomal small nuclear RNAs (snRNAs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002638">
        <property type="protein sequence ID" value="GCB63133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQG1"/>
    <dbReference type="STRING" id="75743.A0A401NQG1"/>
    <dbReference type="OMA" id="FTHRHAL"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12413">
        <property type="entry name" value="RRM1_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12414">
        <property type="entry name" value="RRM2_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12415">
        <property type="entry name" value="RRM3_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12416">
        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000182">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000315">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000340">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="150"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="353"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="505"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="241"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="609"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB63133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="772" mass="86549" checksum="0804F61CDBCA8CBE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRY8</accession>
    <name>A0A401NRY8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Visual system homeobox 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0014652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007949">
        <property type="protein sequence ID" value="GCB63630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRY8"/>
    <dbReference type="STRING" id="75743.A0A401NRY8"/>
    <dbReference type="OMA" id="NCATTAK"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000065">
        <property type="entry name" value="Visual system homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023339">
        <property type="entry name" value="CVC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052294">
        <property type="entry name" value="VSX_homeobox_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46892:SF2">
        <property type="entry name" value="VISUAL SYSTEM HOMEOBOX 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46892">
        <property type="entry name" value="VISUAL SYSTEM HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51496">
        <property type="entry name" value="CVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CVC" evidence="13">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB63630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37013" checksum="43E2B7AF2FF5340E" modified="2019-05-08" version="1">MTAREQSCQPQCKAAAKEWEKGSRSRGFAITDLLGLDSGAASPPPPPPGAPPGHGLPLLPACLGLLASRPLSALHPPGPAFLDVLSELQGRPTTLHSSLPLLRRVTLLDNYQALHNSDDENTSCDRSELKNSAVSQVKRKKRRHRTVFTAHQLEELEKSFNEAHYPDVYAREMLAMKTELAEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILNSGKNGLVGSCAPWLLGMHKKSVDPTPKTKSEATIGEDYVENSIESSQTEVSTDRVPMTTTAEEDNMALDLSSTEKPSSKDNSPKQSISRQPNVEIRQRGLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUM9</accession>
    <name>A0A401NUM9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine zipper putative tumor suppressor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein LAPSER1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LZTS2</name>
        <name evidence="9" type="synonym">LAPSER1</name>
        <name evidence="11" type="ORF">scyTo_0000293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytoskeleton</location>
            <location evidence="9">Microtubule organizing center</location>
            <location evidence="9">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the LZTS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000057">
        <property type="protein sequence ID" value="GCB64596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUM9"/>
    <dbReference type="STRING" id="75743.A0A401NUM9"/>
    <dbReference type="OMA" id="LQHNYVQ"/>
    <dbReference type="OrthoDB" id="10030037at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051168">
        <property type="term" value="P:nuclear export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051255">
        <property type="term" value="P:spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03026">
        <property type="entry name" value="LZTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028597">
        <property type="entry name" value="LZTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF4">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06818">
        <property type="entry name" value="Fez1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="479"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB64596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="683" mass="77490" checksum="8F1CEC6BAC6FE0A5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVN6</accession>
    <name>A0A401NVN6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">scyTo_0009898</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 31">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01004153">
        <property type="protein sequence ID" value="GCB64941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVN6"/>
    <dbReference type="STRING" id="75743.A0A401NVN6"/>
    <dbReference type="OMA" id="CLECPVH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000029">
        <property type="entry name" value="Ephrin type-A receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000023">
        <property type="entry name" value="Ephrin type-A receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000019">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000059">
        <property type="entry name" value="Ephrin type-A receptor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF20">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 24" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019179265" description="receptor protein-tyrosine kinase" evidence="24">
        <location>
            <begin position="28"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="28">
        <location>
            <begin position="29"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="326"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="436"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="507"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="26">
        <location>
            <begin position="815"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="71"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="GCB64941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="888" mass="100072" checksum="C0C48A804AE80ADC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWE6</accession>
    <name>A0A401NWE6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0007667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002821">
        <property type="protein sequence ID" value="GCB65189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWE6"/>
    <dbReference type="STRING" id="75743.A0A401NWE6"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="8163" checksum="FB1F64A4DA5D7E1A" modified="2019-05-08" version="1">MPRMIAEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWM2</accession>
    <name>A0A401NWM2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002829">
        <property type="protein sequence ID" value="GCB65264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWM2"/>
    <dbReference type="STRING" id="75743.A0A401NWM2"/>
    <dbReference type="OMA" id="YPAHVEL"/>
    <dbReference type="OrthoDB" id="5877983at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22077">
        <property type="entry name" value="WH2_WAS_WASL-2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="280" mass="29889" checksum="8F5375F3E51FE604" modified="2019-05-08" version="1">MGLRLPGEADKKVSNFVGHTCVDAIGALRSCLYPAHVELSKQNKDEQKGRNALLGDIHKGVRLKKVVQANDRSAPIINKSKGGNGTGAVGGGATPAAMGGLFQGGFPALRPTGQRDASERGSKPAVQPPSMKMQTSRYSVQNDSTRNDKSASNQPDLSKLPAREGPARSGGHSNGGKLASPPLPPVRSSSTELTSRNQHVPLYSVAPPPPPPPPPPLPLKVRQGLSNAQAPVYDDFESKYHFHSVEDLPPPDEYKSFPRTYPSKQPRVSQKGHRATTPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX68</accession>
    <name>A0A401NX68_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0014893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008176">
        <property type="protein sequence ID" value="GCB65466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX68"/>
    <dbReference type="STRING" id="75743.A0A401NX68"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000097">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000103">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049388">
        <property type="entry name" value="FBN_EGF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040872">
        <property type="entry name" value="Fibrillin_U_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF5">
        <property type="entry name" value="FIBRILLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21364">
        <property type="entry name" value="EGF_FBN_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18193">
        <property type="entry name" value="Fibrillin_U_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019208081" description="EGF-like domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB65466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="280" mass="30150" checksum="31146E2F5C545241" modified="2019-05-08" version="1">MGAWWTAKFVLGCAILICLCIEETLTQQESQFGAARFTGAGDRELQSRVRRRGQDSLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNTCGDGFCSRPNMCTCANGQLSPGCGSGSIQQCNVRCMNGGSCSDDNCVCQKGYTGTHCGQPVCKNGCQNGGRCIGPSRCACVYGFTGPHCERDKTETQGAKCKDQLNHGRQVETSPAIELNDQSPLKEQDPVVSSDDQAYSLISYPETGSVGNTVTQSHLEENDPKHGPLKMEENPIYSETGAPELNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXP0</accession>
    <name>A0A401NXP0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transmembrane protein 200A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0004825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM200 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001451">
        <property type="protein sequence ID" value="GCB65648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXP0"/>
    <dbReference type="OMA" id="GMEQGTR"/>
    <dbReference type="OrthoDB" id="9994280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018787">
        <property type="entry name" value="DUF2371_TMEM200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815">
        <property type="entry name" value="AGAP005329-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 200C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10177">
        <property type="entry name" value="DUF2371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB65648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49512" checksum="2C2842FF50CC1123" modified="2019-05-08" version="1">MTTTVEDTAIKSQENFSSQPDISSPPKLPQPKDRSRDNKDAKGKIKMRSPSGLFVILGLFIVIVGIAIAVVGYWPHKHNSRVSVTHQGINSSESKVATQHVRVKLQSHPRLKQEKLKLIGPLIMGFGLFIFICANTVLHENRDRETKLLAQTNIYSMAGQTCNGENREPKQIPSPTSTETNFRCLEQCCATEIACRAIHGHTSPQCTDIWADCHRSVEPKMTAQLLHHQRPSPSASLHSVQSDSCNSSERNLSVPLDCDTDSLISMPVVLPVIKLNNCIIDTPDTAVMEDIELDQKVVMVSTEDLSQLQSFGYIRSSSIHSAEDATRGVDMDYSLPSKSFSTRLIGKLLSPVTTRKVYGSDMQLHTTCGYSKSFDLGKDANMLSEQKGEQKHRSWPRLDCNYIKKYLKLENREDSVDRLLEQVEREYASEEQNIQELSNPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXP7</accession>
    <name>A0A401NXP7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002864">
        <property type="protein sequence ID" value="GCB65635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXP7"/>
    <dbReference type="STRING" id="75743.A0A401NXP7"/>
    <dbReference type="OMA" id="TIHIRTQ"/>
    <dbReference type="OrthoDB" id="9999986at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17157">
        <property type="entry name" value="DCX2_DCDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17155">
        <property type="entry name" value="DCX_DCDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043188">
        <property type="entry name" value="DCDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056415">
        <property type="entry name" value="DCX2_DCDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057424">
        <property type="entry name" value="Ubiquitin_DCDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302:SF3">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24478">
        <property type="entry name" value="DCX2_DCDC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25510">
        <property type="entry name" value="Ubiquitin_DCDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCDC1 second doublecortin-like" evidence="2">
        <location>
            <begin position="172"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DCDC1 second doublecortin-like" evidence="2">
        <location>
            <begin position="280"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="3">
        <location>
            <begin position="490"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB65635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="103461" checksum="EFC361CE92B02F56" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXY4</accession>
    <name>A0A401NXY4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translocating chain-associated membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0004852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001457">
        <property type="protein sequence ID" value="GCB65739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXY4"/>
    <dbReference type="STRING" id="75743.A0A401NXY4"/>
    <dbReference type="OMA" id="HYICLYT"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016447">
        <property type="entry name" value="Translocation_assoc_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371:SF10">
        <property type="entry name" value="TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371">
        <property type="entry name" value="TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005449">
        <property type="entry name" value="Translocation_assoc_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="39"/>
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            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
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        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="218"/>
            <end position="238"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="250"/>
            <end position="272"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="13">
        <location>
            <begin position="115"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB65739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="371" mass="43178" checksum="6CEB2BF761CBC30C" modified="2019-05-08" version="1">MGLRKKSKNPAVFSHEFVIQNHADIVSCIAMVILLGLMFEVTAKFAIMFITVQYNVTYINIDEGTESISFYEYGFKDLATIFFYMLIAIILHAVIQEYILDKINRRLHLSKTKHSKFNESGQLAFFYLFSFIWGGSILTGEKFTTDPTLLWERYPHSHMFFQVKFFYICQIAYWLHALPELYFQKVRKEDIARQLYYICLYIFHVTGAYILNLHRLGLILLVPHYLVELLFHASRLFYFSDENKQKGFTLWALLFVMARLLTLTLSVLTFGFGLARAENQDFSVANGNFNTLTVRISCLAAICLTQAWMMWKFINFQLKKWREHTQNQIPRKKVANTKNKPSKKECKANTSNGTVKTESGTSPRARKAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY45</accession>
    <name>A0A401NY45_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005599">
        <property type="protein sequence ID" value="GCB65799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="75743.A0A401NY45"/>
    <dbReference type="OMA" id="WFRNEVR"/>
    <dbReference type="OrthoDB" id="9983389at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00098">
        <property type="entry name" value="IgC1"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="V-set"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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            <end position="966"/>
        </location>
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        <location>
            <begin position="259"/>
            <end position="282"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="966" mass="109530" checksum="D91B5019987FD2C0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ17</accession>
    <name>A0A401NZ17_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005630">
        <property type="protein sequence ID" value="GCB66111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ17"/>
    <dbReference type="STRING" id="75743.A0A401NZ17"/>
    <dbReference type="OMA" id="FESFMVW"/>
    <dbReference type="OrthoDB" id="5984625at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043460">
        <property type="entry name" value="MEDAG/TEX26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26 ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="348" mass="39670" checksum="074EA5F0EE5E207B" modified="2019-05-08" version="1">MDLILTSYVKEVTNPVATQCTELPEHSRYCPEVKNHHRKTKKSKEAANAQKVTKKAHTKGKESKKHGKRKADLRTSAPDLCRGGSLTFDPYQTTSQRDFIYRPGSVPDQLRTGSSNGYTFPFQLHEPIGNTTYKNDYAWNTSSSQQPMPRGMSAQHKDDAIQKCKCLLLWKLLLEDPEAYHRVKTCFMKSLSSEDMQKVRACQFDTIYRQDYLGVQQESLKCPPCLPNIRRPDEQSPPFTDKQHRSRKQTQKPGTAVCTTRYGSNKHWDIAAKGIVPSVTQAHIRNQESRKQPTTYAREYGNFNLDFSKILKSLEPKAMQSYLASLPIKDQEVMLQFLGNMATGSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZT8</accession>
    <name>A0A401NZT8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0007869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002930">
        <property type="protein sequence ID" value="GCB66375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZT8"/>
    <dbReference type="STRING" id="75743.A0A401NZT8"/>
    <dbReference type="OMA" id="CIVGPIC"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF1">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="105" mass="11924" checksum="F5E0DA3A685C3801" modified="2019-05-08" version="1">MASLDWLIVAIASFIVFQIMFHYLSARISVFFCNGYRPLTDIQKTEWNSRVVSTFHALVVGLLCLYLLWFDDAVNADPIWGEPTLVKLNVGLTAGYLISGEYIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P064</accession>
    <name>A0A401P064_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005672">
        <property type="protein sequence ID" value="GCB66494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P064"/>
    <dbReference type="STRING" id="75743.A0A401P064"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04021">
        <property type="entry name" value="C2_E3_ubiquitin_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000122">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="86"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="438" mass="46960" checksum="80C2A66C78EB9843" modified="2019-05-08" version="1">MVYLLEAIYITPGQEAVGRVRASLDGARARANTRTRARGCRCRRWESESGAARRSGETRSKGESGAGATAQEEPEGGEACKAANIAAYDMATACSSNSQNGRSQLHVTVASAKLKRRKNWFGTAIYVELSADGELKKSAKSHSSSNPKWDEHLIMNVTPHTKLEFKIWSHHTLKSDALLGKATLDICQALELHNRKLENIKEVLKLTLENKNGVVQTGDLTVFLDGMTVDQESVPNGTAPATKVQQNGDAIHVNGGESSTRARTRSNTETSNCADSPSTSSSRQSAASSPVVNGESNHSPCHLAARPKSTTAPKSSTTQGADSTVNGEIAPPPPAAAPPTPPSISSTSSPKITVTMTSKQLQQLQAIAQLQQQAHLVVQQLILLQKPQLWTPLPEAIQSQTVENLDIQLQIHLLGLLDSSQTALAQNHCQLGKYMNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2S6</accession>
    <name>A0A401P2S6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase 1 regulatory subunit 37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 68</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0000724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP1R37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000146">
        <property type="protein sequence ID" value="GCB67396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2S6"/>
    <dbReference type="STRING" id="75743.A0A401P2S6"/>
    <dbReference type="OMA" id="TAITCEG"/>
    <dbReference type="OrthoDB" id="10034042at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF9">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB67396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="124" mass="13580" checksum="D56642367ABD3A01" modified="2019-05-08" version="1">MLYAVIRLKYFSPSLTCLETLNLGRNPLSNEGIHRLKEALIANRSVIRLGLASTAITCEGAIAVAEFIVESAGIIRLDLRRNRIRTGGLMALSLALRLNHSLARLDLDKEPLGETVSRQGLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2T0</accession>
    <name>A0A401P2T0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0008058</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclin family. Cyclin E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003019">
        <property type="protein sequence ID" value="GCB67422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2T0"/>
    <dbReference type="STRING" id="75743.A0A401P2T0"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20580">
        <property type="entry name" value="CYCLIN_CCNE2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000024">
        <property type="entry name" value="G1/S-specific cyclin-E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029431">
        <property type="entry name" value="TP53INP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671:SF0">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14839">
        <property type="entry name" value="DOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 16" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="18">
        <location>
            <begin position="346"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="19">
        <location>
            <begin position="440"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB67422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="604" mass="69233" checksum="06955F2CDCF32691" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3M2</accession>
    <name>A0A401P3M2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHTF1/2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001589">
        <property type="protein sequence ID" value="GCB67713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3M2"/>
    <dbReference type="STRING" id="75743.A0A401P3M2"/>
    <dbReference type="OMA" id="IPTFCRL"/>
    <dbReference type="OrthoDB" id="10066656at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039775">
        <property type="entry name" value="PHTF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021980">
        <property type="entry name" value="PHTF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680:SF8">
        <property type="entry name" value="PROTEIN PHTF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680">
        <property type="entry name" value="PUTATIVE HOMEODOMAIN TRANSCRIPTION FACTOR PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12129">
        <property type="entry name" value="PHTF1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="PHTF1/2 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB67713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="684" mass="77417" checksum="24B628CAEFBFB084" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5G8</accession>
    <name>A0A401P5G8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Neurokinin A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tachykinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007207">
        <property type="protein sequence ID" value="GCB68330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5G8"/>
    <dbReference type="STRING" id="75743.A0A401P5G8"/>
    <dbReference type="OMA" id="GQMSHKR"/>
    <dbReference type="OrthoDB" id="9936276at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007217">
        <property type="term" value="P:tachykinin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013055">
        <property type="entry name" value="Tachy_Neuro_lke_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008216">
        <property type="entry name" value="Tachykinin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11250">
        <property type="entry name" value="TACHYKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11250:SF0">
        <property type="entry name" value="TACHYKININ PRECURSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01829">
        <property type="entry name" value="PROTACHYKNIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00267">
        <property type="entry name" value="TACHYKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018996021" description="Neurokinin A" evidence="8">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13425" checksum="56B5383C2B19C358" modified="2019-05-08" version="1">MRTLRLLALTVSILVLTEVFCEEISPNQVVTLWAASDHSQDQKLQPDSVRDLLKRVARKPRPGQFFGLMGRRSFENKPLTRKRHKLENFVGLMGKRSSAADFPSEWKTVQTFVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5L9</accession>
    <name>A0A401P5L9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0000873</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:73740"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:73744"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000180">
        <property type="protein sequence ID" value="GCB68396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5L9"/>
    <dbReference type="STRING" id="75743.A0A401P5L9"/>
    <dbReference type="OMA" id="NECRMSK"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000083">
        <property type="entry name" value="synaptic vesicular amine transporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000116">
        <property type="entry name" value="synaptic vesicular amine transporter isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF30">
        <property type="entry name" value="SYNAPTIC VESICULAR AMINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="109"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB68396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="606" mass="66191" checksum="A672DCAE51D275E8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5Y3</accession>
    <name>A0A401P5Y3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004483">
        <property type="protein sequence ID" value="GCB68527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5Y3"/>
    <dbReference type="STRING" id="75743.A0A401P5Y3"/>
    <dbReference type="OMA" id="HNTNENM"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058856">
        <property type="entry name" value="ASCC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26582">
        <property type="entry name" value="ASCC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="494"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB68527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="721" mass="81869" checksum="14A4FBD3AC6F5E0B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P664</accession>
    <name>A0A401P664_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="10">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0005329</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01001646">
        <property type="protein sequence ID" value="GCB68596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P664"/>
    <dbReference type="OMA" id="NHRAQED"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025806">
        <property type="entry name" value="TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056921">
        <property type="entry name" value="TARBP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25050">
        <property type="entry name" value="TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51624">
        <property type="entry name" value="SAM_MT_TRMH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TARBP1" evidence="14">
        <location>
            <begin position="242"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="13">
        <location>
            <begin position="1412"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB68596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1575" mass="178474" checksum="C7326604A6A9C785" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7T2</accession>
    <name>A0A401P7T2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SID1 transmembrane family member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0013934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007312">
        <property type="protein sequence ID" value="GCB69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7T2"/>
    <dbReference type="STRING" id="75743.A0A401P7T2"/>
    <dbReference type="OMA" id="GLHQTMT"/>
    <dbReference type="OrthoDB" id="416618at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051033">
        <property type="term" value="F:RNA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025958">
        <property type="entry name" value="SID1_TM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185:SF16">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMEBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018984244" description="SID1 transmembrane family member 2" evidence="9">
        <location>
            <begin position="39"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="96582" checksum="0F0F838BF54097CA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7T9</accession>
    <name>A0A401P7T9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0010516</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.86" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01004550">
        <property type="protein sequence ID" value="GCB69186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7T9"/>
    <dbReference type="STRING" id="75743.A0A401P7T9"/>
    <dbReference type="OMA" id="FINEDNM"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045779">
        <property type="term" value="P:negative regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045659">
        <property type="term" value="P:negative regulation of neutrophil differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045579">
        <property type="term" value="P:positive regulation of B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057509">
        <property type="entry name" value="C2_SHIP1-2_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057510">
        <property type="entry name" value="C2_SHIP1-2_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24147">
        <property type="entry name" value="C2_SHIP1-2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24150">
        <property type="entry name" value="C2_SHIP1-2_first"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB69186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="701" mass="80268" checksum="7CD1EC3C1207DB1B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P838</accession>
    <name>A0A401P838_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0013954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007329">
        <property type="protein sequence ID" value="GCB69309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P838"/>
    <dbReference type="STRING" id="75743.A0A401P838"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13443" checksum="D9A9853D8A3A0115" modified="2019-05-08" version="1">MEIKGSARIVEQDLAIFMIPTNPPPTFRKPELWSDEFTDFVKKCLVKNPEHRTTATQLLQHNFIKNAKSVAILRDLITEAMEIKAKRHQELQRELEEEDENSVSVTMTCSNYILVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P866</accession>
    <name>A0A401P866_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000216">
        <property type="protein sequence ID" value="GCB69306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P866"/>
    <dbReference type="OrthoDB" id="9634265at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="15348" checksum="C96419E7CE64CECE" modified="2019-05-08" version="1">MQWRHVEDGRHVEDGRHVEDGRHVEDGRHVEDGRHVEDGRHVEDGCHVEDGAMWKMGAMWKMDAMWKMDAMWKMGAMWKMGAMWKMGAIWKMGDTWKMGAMWKMGTMWKMGAMWKMGAMWKMGAMLEKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAY7</accession>
    <name>A0A401PAY7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004691">
        <property type="protein sequence ID" value="GCB70287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAY7"/>
    <dbReference type="OMA" id="DQHYAHP"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="432" mass="46046" checksum="4A5313AA0FDDB66E" modified="2019-05-08" version="1">MRLQERTVQGLDREAAGATVQGPERRTLERQCRVQTARQLERQCSVQTTRQLERQCSVQSARQLERQCRVQTKRQLERQCRVQTARQLVRQCSVQTTRQLERQCSVQSARQLERQCRVQTARQLERQCRVQTARQLERQCSVQSARQLERQCRVQTKRQLERQCRAQNAGHWSSSAGSRPRGSWSDSAVSSPQGSWSDSAGSRTQDTRATVQGPDREAAGATVQGPDREAAGATVQGPGREAAGATVQGPDREAAGSTVQGPDRKAAGATVQGPDHEAAGPTVQGPDRKAAGETVQGPDHEAAGETVQGPDHKAAAATVQGPDHEAAGPTVQGPDRKAAGETMQGPDRKAAGETVQIPDREAAGETVQGPDHEAAGATVQGPDRKAAGETVQGPDHETAGAAVQGPAHEAAGTHSAGSRPQGGWSDSAGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB00</accession>
    <name>A0A401PB00_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004692">
        <property type="protein sequence ID" value="GCB70298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB00"/>
    <dbReference type="STRING" id="75743.A0A401PB00"/>
    <dbReference type="OMA" id="GITLEWH"/>
    <dbReference type="OrthoDB" id="1099686at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF14">
        <property type="entry name" value="LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="287"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB70298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="598" mass="67090" checksum="51C4E3DF075A5B33" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB94</accession>
    <name>A0A401PB94_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000276">
        <property type="protein sequence ID" value="GCB70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB94"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="16286" checksum="BC0E501480DE67FD" modified="2019-05-08" version="1" fragment="single">AVAGDPGSDCDTVCVSQAVSVGNVSVTEALSVRSAFPTGDTTCVDTASAYDDASVCDAVSVRGVTSTGDATSVGDIAFIGDATSVGDIAFIGDATSANDALSVDRAISSCHSESVGYVVPVSHTVCTDDTVSVSDTVSVCNAVFPSYAVSARDYVSVSDTVCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBH0</accession>
    <name>A0A401PBH0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000281">
        <property type="protein sequence ID" value="GCB70464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBH0"/>
    <dbReference type="STRING" id="75743.A0A401PBH0"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="213"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="500" mass="56107" checksum="20BFAE7EB55241D9" modified="2019-05-08" version="1">MDRMVDQYGLRAAYPYLDNVTICSHDQQDHDVNLQRFLQAAQSLNLTYNKEKCVSRTTRLAILDYVVENGVLGLGPDRMCPLTEHPPSHSLKALKRCLGLFYYAQWVPNYADKARPLIQTTSFPLTAEARSAFSRIKADITKAAMHAVDESVPFQVESAASDVALAATLNQAGKPVAFFSRTLHASEIRHSSVEKEAQSIVEAVRHWRHYLAVAPIKALCNQRHEDWKEKFGPIGLNCKELTGDTEMDDYFEIQDAHIIITTPVHVVKDECRGATLEVVVSRMKTVQLAVSRVSKQTDDKMLRFVAVSATIPNVKDIAEWLSDGKGPGISMKIDESYRPVKLRKVVIGFPCSSTQTEFKFDLSLNYRTASVIQTYSEQKPALVFCATRKGVQQAASILAKDAKFVMTMEHKQRLQKYTNSVKDTKLRDLLIYGVGYHHAGMDLSDRKAIEAAFTAGDVPVLYSPNIQGSNPNVPHDLHVFLPNILERDSETQRLQQRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBV6</accession>
    <name>A0A401PBV6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0008622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003344">
        <property type="protein sequence ID" value="GCB70603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBV6"/>
    <dbReference type="STRING" id="75743.A0A401PBV6"/>
    <dbReference type="OMA" id="RFAELVX"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048715">
        <property type="term" value="P:negative regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000050">
        <property type="term" value="P:regulation of non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001914">
        <property type="entry name" value="Disheveled associated activator of morphogenesis, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000002">
        <property type="entry name" value="Dishevelled associated activator of morphogenesis 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF7">
        <property type="entry name" value="DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="458"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="3">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="732"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB70603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="923" mass="106519" checksum="B01FD16EA4FB8DC7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCE8</accession>
    <name>A0A401PCE8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0005774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001849">
        <property type="protein sequence ID" value="GCB70779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCE8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="9376" checksum="29E4351B8E218FC1" modified="2019-05-08" version="1">MCAETCYLESKSTFRSKAFLMLLGGDFRLFQLQPEAFILEDRSLFKYLLLTLTPPAIFQSLPVDRTRFFKSCPELYEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDG9</accession>
    <name>A0A401PDG9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0008777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003420">
        <property type="protein sequence ID" value="GCB71167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDG9"/>
    <dbReference type="STRING" id="75743.A0A401PDG9"/>
    <dbReference type="OMA" id="SHNANEK"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB71167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19099" checksum="D03A99A7D219002F" modified="2019-05-08" version="1">MKRIGRQIVLLCSGFLGLALGAFPTSVQIGGLFMRYSDQEYSAFRFAIYLHNTNPNTTEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGMYDKRSVHTLTSFCGALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWTKFVFLYDTDRGEFDLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDY6</accession>
    <name>A0A401PDY6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0005917</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the R-spondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001921">
        <property type="protein sequence ID" value="GCB71370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDY6"/>
    <dbReference type="STRING" id="75743.A0A401PDY6"/>
    <dbReference type="OMA" id="CMTSCPL"/>
    <dbReference type="OrthoDB" id="10257656at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051514">
        <property type="entry name" value="R-spondin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043601">
        <property type="entry name" value="Rspo_Fu-CRD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987">
        <property type="entry name" value="NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987:SF1">
        <property type="entry name" value="R-SPONDIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15913">
        <property type="entry name" value="Furin-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019425649" evidence="11">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="R-spondin Fu-CRD" evidence="12">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="13">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB71370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="274" mass="31279" checksum="ACE77998A4628F4C" modified="2019-05-08" version="1">MQFRMLSVVLILLNCMEYIGSHNASRGRRHRRTNASVSQSCPKGCDRCSEYNGCLSCKPRLFFFLERNGMRQTGVCLSSCPSGYYGVRTPEMNKCTRCRADNCDTCFTKNFCTKCKPGFYLHKGRCFDICPEGFFPSNQTMECTTHVDCEVSAWNAWSSCTKRGKTCGFRRGSESRKREIVQFPSAHGKLCPKITESRKCIVQKKRCSIGEKDKVKIKRSRKEGNKEAKQGKQAKNRGKENKNNREGGRNEKTQNKKRRGQNKKLITTTVSTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFR5</accession>
    <name>A0A401PFR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHD finger protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0006121</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAYP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002005">
        <property type="protein sequence ID" value="GCB71945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFR5"/>
    <dbReference type="STRING" id="75743.A0A401PFR5"/>
    <dbReference type="OMA" id="NRNVYIM"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071564">
        <property type="term" value="C:npBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15528">
        <property type="entry name" value="PHD1_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15529">
        <property type="entry name" value="PHD2_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21085">
        <property type="entry name" value="WH_NTD_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000202">
        <property type="entry name" value="PHD finger protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038045">
        <property type="entry name" value="PHF10_PHD_finger_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="381"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="437"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB71945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="502" mass="56780" checksum="0E0EE7057788EE79" modified="2019-05-08" version="1" fragment="single">GWQRSAVEMAAAVSSGRLYDSNPATPGAQSSREDTEETSNDDATSQPAKRRRMGSGDSCKSSDTTQDFSSSYFPAEMLTEYKWPADDTVEYYMLQEQVSEYLAVTSFKRKYPDLERRDLSHKEKLYLREMNVITETQCTLGLTALRSDEVIDLMIKEYPTKYAQYAVVLQDRERQQITDRYKEYSQMQLQNTQKVEPSKVPEYIKKAAKKAAEFNSNFNRERMEERRAYFDLQTQVIQVPQGKYKVLPPERTKVGAYPVALIPGQFQEYYKRYSPNELRYLPVNTALYEPPLDPELPAPDSDGDSDDAEDGRGEDERKEDKGLSDTSSGSTTDGESLIEHQDDSSQGKQTPKEKGTRAWKDAKRSVTPKSVTGYKPKIIPNAICGICLKGRESNKKSKPEALIHCSQCDNSGHPSCLDMLSELVSIIKTYPWQCMECKTCIVCGQPHHEEEMMFCDQCDRGYHTFCVGVASIPSGRWICECCANVPSTTKKGGRRGKSNKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHQ0</accession>
    <name>A0A401PHQ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0002119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000509">
        <property type="protein sequence ID" value="GCB72665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHQ0"/>
    <dbReference type="STRING" id="75743.A0A401PHQ0"/>
    <dbReference type="OMA" id="ICATCEG"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000021">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF7">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="12">
        <location>
            <begin position="261"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="11">
        <location>
            <begin position="669"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB72665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="78575" checksum="1E2176BD98BA6FF5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIC6</accession>
    <name>A0A401PIC6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein of 72 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0006518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CEP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002209">
        <property type="protein sequence ID" value="GCB72885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIC6"/>
    <dbReference type="STRING" id="75743.A0A401PIC6"/>
    <dbReference type="OMA" id="HVVPNDM"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000489">
        <property type="entry name" value="Centrosomal protein of 72 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055320">
        <property type="entry name" value="CEP72-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311">
        <property type="entry name" value="HEAT SHOCK REGULATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311:SF6">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="11">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="471"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB72885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="652" mass="74167" checksum="72FDEB95C64DA6D6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIT2</accession>
    <name>A0A401PIT2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0006584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002242">
        <property type="protein sequence ID" value="GCB73019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIT2"/>
    <dbReference type="STRING" id="75743.A0A401PIT2"/>
    <dbReference type="OMA" id="TLVACRW"/>
    <dbReference type="OrthoDB" id="414661at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000007">
        <property type="entry name" value="Transmembrane serine protease 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB73019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="250" mass="27679" checksum="8C2615658373A5FD" modified="2019-05-08" version="1">MIITSIEAPRPQEIKTRLPSTRILKILIITSILLFVVIVTVLTAIVLLLYFPAKCIDNDACKRSDHAACGGIGTKSGEWPFQVSLQRNGNHICGATLVACRWILSAAHCFEGRDTESWTAVFGLHFLDQSNNHNVQHRKIKKIIIHPRNTPATFDYDVALLELVHPVQYTDFVQPACLPAATASLLTGRRCIIIGWGTTEENGSPSNELLQTEVKVFNNSQCRIGKVRITKQMICAGFLEGGRDACQVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJB6</accession>
    <name>A0A401PJB6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000604">
        <property type="protein sequence ID" value="GCB73191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJB6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019273870" description="MAM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10633" checksum="8AC4F58629B51AB1" modified="2019-05-08" version="1">MSPLTLLILYAVQFASAEFLGSNGSCDFEDDTCGYESDPNNDPWIVNLQEMDKDSHLALNQVLWYLHFWNADGLFDKGAIAVTNFIEGKRLGGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJV1</accession>
    <name>A0A401PJV1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002331">
        <property type="protein sequence ID" value="GCB73402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJV1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="165" mass="17790" checksum="D0047DEDC944F8D6" modified="2019-05-08" version="1">MVCLRNVLWVAASDSPQLSIASYWREDILRTEVAGALPCRACPSEAVRAGATQSVPVTGPMDDRVLGTIIQQPGPMLYRVHVRDGESDKHLDHPCIRSSILCDALLEGPGQHLAPNAADPTSTIPRGSRVNMPNAEDSDSEMEVPPPDIASDKSPDNQRMMVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKQ5</accession>
    <name>A0A401PKQ5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0002795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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                <person name="Hyodo S Kuraku.S."/>
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            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MITOCHONDRIAL DYNAMICS PROTEIN MID49"/>
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    </dbReference>
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</entry>
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            <taxon>Carcharhiniformes</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
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                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <end position="303"/>
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="688" mass="77787" checksum="FA993DBA90593112" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401PMN6_SCYTO</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
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                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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                <person name="Kuratani S"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="267"/>
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        </location>
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        </location>
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            <begin position="40"/>
            <end position="50"/>
        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="568"/>
            <end position="611"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="982" mass="107751" checksum="B55AE1C26EDC81A7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQG2</accession>
    <name>A0A401PQG2_SCYTO</name>
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        <recommendedName>
            <fullName evidence="2">DUF4587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012460">
        <property type="protein sequence ID" value="GCB75359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQG2"/>
    <dbReference type="OMA" id="QVIMNNI"/>
    <dbReference type="OrthoDB" id="8962708at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027904">
        <property type="entry name" value="DUF4587"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038915">
        <property type="entry name" value="PRR29-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28604">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28604:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15248">
        <property type="entry name" value="DUF4587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4587" evidence="2">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="197" mass="22130" checksum="C6C80BE4C0281664" modified="2019-05-08" version="1">MYFAESFSPQGVQIIQQQIPQQPTTIFQNLSGMQHLQTPPIRNGHVKEDLVELMMIQNAQMHQVIMNNITMAALTSFGYNAQPQPAIQNPVTIRMEESEPDTVYHHHYQPWPYPAYPSWPTLPPQAQTQSQPQAHHMLRLLQENSRPTVRHVSGDAPPSPRREIKAVPPPPPPSATGTVGADVRPASEYYDVADGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR51</accession>
    <name>A0A401PR51_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0015349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008671">
        <property type="protein sequence ID" value="GCB75608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR51"/>
    <dbReference type="STRING" id="75743.A0A401PR51"/>
    <dbReference type="OMA" id="ICHRQCE"/>
    <dbReference type="OrthoDB" id="9398337at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000022">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB75608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="7643" checksum="8DD0FFC94EAF6192" modified="2019-05-08" version="1">MAKALAPEELASSSHTFKNKTFKKPKTCNICKQLISSSQGLSCRVCKYACHKKCEPKVSQNKSRLFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRM9</accession>
    <name>A0A401PRM9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009967">
        <property type="protein sequence ID" value="GCB75784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRM9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="78" mass="9119" checksum="B1BFB9E5BD0D7351" modified="2019-05-08" version="1">MDRDRRGTALQQTNQLSTERFGSHCECFRPILLNAKQWSEFPACALEHCWKCVLEQLDVHAQFTLIRKFLKFNGTHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRV1</accession>
    <name>A0A401PRV1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">triacylglycerol lipase</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01015141">
        <property type="protein sequence ID" value="GCB75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRV1"/>
    <dbReference type="STRING" id="75743.A0A401PRV1"/>
    <dbReference type="OMA" id="KEWNISF"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000003">
        <property type="entry name" value="Patatin-like phospholipase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF29">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="244" mass="27394" checksum="E67CDA883407B4F4" modified="2019-05-08" version="1" fragment="single">MSPLVEFYPWSINPELHPELFCTVKAGGVSNHCVRSLGVGVYLLEFRLSSLLKQCESGANIIDVSKEARKRFLGPLHPSFNLMKIIRSRLYKGLPDNAHELATGRLGISLTRVSDGENVLVTVFNNKEELIQACICSTFIPVYCGLIPPMLQGVRYVDGGITDNLPQYELKNTITVSPFAGESDICPRDCSSNMHELRITNTSIQFNLQNLYRLSKALFPPEPEVMRDMCKQGYSDAFDFLKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS30</accession>
    <name>A0A401PS30_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016457">
        <property type="protein sequence ID" value="GCB75925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS30"/>
    <dbReference type="STRING" id="75743.A0A401PS30"/>
    <dbReference type="OMA" id="MVNCAIV"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF66">
        <property type="entry name" value="PEPSINOGEN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="12762" checksum="C5800A2D29593F56" modified="2019-05-08" version="1">MVDTGTSYLTVPSQELGQLLQTIGAYKDEYGEYLVNCDTVGNLPSLTFIINGVHLTIPGSAYIQQVSGYCVVAISSTYLRAPTQNGLFWILGDVFLREFYSIYDRGNNRMGFATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSZ0</accession>
    <name>A0A401PSZ0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015229">
        <property type="protein sequence ID" value="GCB76218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSZ0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="42" mass="5054" checksum="86D9079AE595D63F" modified="2019-05-08" version="1" fragment="single">LSFYGVIPLRVCVLGTCQLKMVKLRLTFQGFHQELWRDSRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTW1</accession>
    <name>A0A401PTW1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0016575</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010096">
        <property type="protein sequence ID" value="GCB76561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTW1"/>
    <dbReference type="STRING" id="75743.A0A401PTW1"/>
    <dbReference type="OMA" id="RQQRDKM"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB76561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="124" mass="14298" checksum="906708A09C6AC55C" modified="2019-05-08" version="1">MGVTSCKGTSRAKKRLGAMPLIDLQEKIGLNIDKWLLVQSGVQPNGRAARCHAFEKEWIECAHGIGKIRAMKECKLEMDDFHECMQRQKLRKRLAEIKMQKEKLMKEGKYTPPDHHIGNDEQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX35</accession>
    <name>A0A401PX35_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine-protein phosphatase non-receptor type</fullName>
            <ecNumber evidence="10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0017646</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01011632">
        <property type="protein sequence ID" value="GCB77714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX35"/>
    <dbReference type="STRING" id="75743.A0A401PX35"/>
    <dbReference type="OMA" id="NGWLWNG"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09931">
        <property type="entry name" value="SH2_C-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000012">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012152">
        <property type="entry name" value="Tyr_Pase_non-rcpt_typ-6/11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000929">
        <property type="entry name" value="Tyr-Ptase_nr_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="247"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="436"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB77714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="594" mass="67643" checksum="A17D1C49CEB265C5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYM4</accession>
    <name>A0A401PYM4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017016">
        <property type="protein sequence ID" value="GCB78244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYM4"/>
    <dbReference type="STRING" id="75743.A0A401PYM4"/>
    <dbReference type="OrthoDB" id="9950569at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="229" mass="23913" checksum="ACE345838BD06735" modified="2019-05-08" version="1">MVLGGRRGGPSRGRETRRRRGPALPPNGRQAEPAGGLPTVSEHIVEAVASSRERRGLSLAGVKKALSAAGYDVPRINSRVNQAVRSLVSGGSLLQTAGTGASASFRINRQHLEGQSRPAAAAPTHRTRRGGGRQQRRAAPGPRAKVKSPGRLPKKKKPGGGGQRKAAGDRRRSTKATGVRRLGGRLRKAGKEPAAPRADPAAGHEGEGEAAATEETSGRQRGRAGKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYQ5</accession>
    <name>A0A401PYQ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYCBP-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013073">
        <property type="protein sequence ID" value="GCB78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYQ5"/>
    <dbReference type="STRING" id="75743.A0A401PYQ5"/>
    <dbReference type="OMA" id="NWRRRMA"/>
    <dbReference type="OrthoDB" id="10263316at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032707">
        <property type="entry name" value="MYCBPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421:SF1">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14646">
        <property type="entry name" value="MYCBPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40018" checksum="D8E8B343075CDDA2" modified="2019-05-08" version="1" fragment="single">KKKEIKREVEEVFPIQEEPEKEDILKGEDIMALAIKTEDLNELHGSRMALKIIPITSRLVIRKQKLKKEVIMKRLIAKPAPPTDELKTVDYSGPGGPRFDTEGRVLPHSILGNLADFKHELLARGLTKIANAISDRHPTETRPQELQVYGKKSKDIIYAKSQNQDHALVNWQWHMAERKKTQQLISNLLNKPVEDLVMNQCEDFGQARQQANLLDQTIASLGPGKGFHVGSEFWALPPMIGDELSGMASTLTQTERGFPPPIVHSGKPRAIKQETGTDFPCDKRKHWKSNSENLHLKQRLEEMKTILRHLDFRQPDIDQLEVIGTGRPFSSMTVERFPLVQKDCPTEGKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ58</accession>
    <name>A0A401PZ58_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0016813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010432">
        <property type="protein sequence ID" value="GCB78360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ58"/>
    <dbReference type="STRING" id="75743.A0A401PZ58"/>
    <dbReference type="OMA" id="AQVWTHK"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="110"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="110"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB78360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="474" mass="51898" checksum="606523437347DB04" modified="2019-05-08" version="1">MLNMAEEHDKMVAEGACSPGCSGSESESVGSPGSLSDSEAQNAGMSEPEEGGGCGRPLSSANGKKLSGEEDERFPACIREAVSQVLKGYDWTLVPMPVRINGTSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSENEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQADSEQGAEQSHLPASQLFKNGHPGDSLPGGRALPDGHHPSEHTGHAQGPPTPPTTPKTDLHTGKHELKREGRPMAENGRQNIDFSNVDIGELSSEVINNMETFDVHEFDQYLPLNGHAVPSDHSHGPNPAGSYSAAYITSSNSAQVIWNHKSASSSSPSSSVSSEPSQQRPHIKTEQLSPSHYNDQQHGSSPQTDYSSYSTQCCSPANAAAAAFSGSQCDYSDVQGPNYYNPYSGYPSSIYQYPYFHSSRRAYASPLLNTLSIPPSHSPTNWDQPVYTTLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ96</accession>
    <name>A0A401PZ96_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0015830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009166">
        <property type="protein sequence ID" value="GCB78438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ96"/>
    <dbReference type="STRING" id="75743.A0A401PZ96"/>
    <dbReference type="OMA" id="FPYFMEH"/>
    <dbReference type="OrthoDB" id="431817at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039846">
        <property type="entry name" value="ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493:SF3">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE ZCCHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB78438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="515" mass="60012" checksum="D1BA322CFEC94D22" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZP4</accession>
    <name>A0A401PZP4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009203">
        <property type="protein sequence ID" value="GCB78627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZP4"/>
    <dbReference type="STRING" id="75743.A0A401PZP4"/>
    <dbReference type="OMA" id="HVSVGIE"/>
    <dbReference type="OrthoDB" id="8964776at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="146" mass="15263" checksum="507EE0BD98BE2E48" modified="2019-05-08" version="1">MGVGIESSQVTVGIESSQVSVGTECSPVSVGIESSHVSIGIESSHVSIDIESSPVSVGIESSPVSIGIESSHVSVGIESSPVSVGIESSHVSIGIESSHVSVGIESSPVSVGIECSPISVGIEFTSQRWYREFTCQHWYREFTSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q022</accession>
    <name>A0A401Q022_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015799">
        <property type="protein sequence ID" value="GCB78633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q022"/>
    <dbReference type="STRING" id="75743.A0A401Q022"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="448" mass="48119" checksum="D3DF13CF65DF81F4" modified="2019-05-08" version="1">MRQATCRNLLVGYVFQVVDYTAAVVGYAISVVGYAIAVVGYAIPGVDYATPVVGYAFPVVVNAIPVVGYAIPVVDYAIPIVDYAIPVVVYVITVIDYAIPVVGYAFPVVGNTILVVGYAFPVVVNAVPVGGYTIPVVGSATPVVGYAFPVVDYAFPVLTMLFQLLTMLFQLLAVLFQFVDYAFPMLIMLFQLLTMLFQLLAVLFQLLLILFQLLAVLFQLLAILFQLLAVLFQLLAILFQLLAMLFKLLDVLLQLLARIFQLSTMLFQLLTTLLQLALALFQLLTVSPVVCYATPVVGYATPVVDYASLVDDYAILVVNYAAPIVGSAFLVVGNTIPVVGCAFPVVGYAFPVVDYATPVVDYATPVYAIPGVGYDTSAVVYAIPVVVSAIPVVGYAAPVVDNVAPVLSMLLQLSATLLQLSAMLLQLSAMLLQLSVMLLQLSAMLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0X6</accession>
    <name>A0A401Q0X6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="28">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">scyTo_0018685</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="28">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="function">
        <text evidence="27">RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:21250"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 3'-end ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a ribonucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77763"/>
            <dbReference type="Rhea" id="RHEA-COMP:17428"/>
            <dbReference type="Rhea" id="RHEA-COMP:18982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:197502"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:77764"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 28">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="28"/>
    <dbReference type="EMBL" id="BFAA01013240">
        <property type="protein sequence ID" value="GCB78990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401Q0X6"/>
    <dbReference type="OMA" id="QAFPIPH"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 28" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="13 28" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0677">Repeat</keyword>
    <keyword evidence="22 28" id="KW-0804">Transcription</keyword>
    <keyword evidence="12 28" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="30">
        <location>
            <begin position="213"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1511"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="1511"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="29">
        <location>
            <begin position="1537"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00051968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00058652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="GCB78990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1559" mass="174578" checksum="FF789D26C9547FFD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2B4</accession>
    <name>A0A401Q2B4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01009376">
        <property type="protein sequence ID" value="GCB79484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2B4"/>
    <dbReference type="STRING" id="75743.A0A401Q2B4"/>
    <dbReference type="OMA" id="SACCREE"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF27">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR-like C-terminal" evidence="2">
        <location>
            <begin position="130"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="557" mass="63181" checksum="2A80E6ED830F21A4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2X1</accession>
    <name>A0A401Q2X1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012079">
        <property type="protein sequence ID" value="GCB79769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2X1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="32" mass="3949" checksum="376AE4C8284138F6" modified="2019-05-08" version="1" fragment="single">MWNAEVRERQFYRLRRLRQKANSGGIIEDQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3M4</accession>
    <name>A0A401Q3M4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotrophin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012146">
        <property type="protein sequence ID" value="GCB79975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3M4"/>
    <dbReference type="STRING" id="75743.A0A401Q3M4"/>
    <dbReference type="OMA" id="WNLYSPR"/>
    <dbReference type="OrthoDB" id="6491780at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005163">
        <property type="term" value="F:nerve growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038180">
        <property type="term" value="P:nerve growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000002">
        <property type="entry name" value="Brain-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020408">
        <property type="entry name" value="Nerve_growth_factor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002072">
        <property type="entry name" value="Nerve_growth_factor-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019846">
        <property type="entry name" value="Nerve_growth_factor_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11589">
        <property type="entry name" value="NERVE GROWTH FACTOR NGF -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11589:SF8">
        <property type="entry name" value="NEUROTROPHIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00243">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001789">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00268">
        <property type="entry name" value="NGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00140">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00248">
        <property type="entry name" value="NGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50270">
        <property type="entry name" value="NGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0339">Growth factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nerve growth factor-related" evidence="5">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="255" mass="28778" checksum="4EACE38F487625D7" modified="2019-05-08" version="1">MIQRRTCKRDCEVGRVMITLLYTMVVLHLGSIKAAPLQSNSTLLNRRSPQDELVRESLLSDEEAAGREYLLDDMVADIQDLGDDASGREWDFYSPRVTLAVRPPGVPPLLFIMEESLSQADVANRTWRAKRQAGAGGVDPSRRGDLSVCDSFSRWVTDRRAAVDVHGMMVTVMIDVPTSTGPLKQYFYETKCNERSTTAQGGCRGVDKRHWISECKTKQSYVRALTMDTQKRAGWRWIRIDTSCVCTLINRTGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4Z6</accession>
    <name>A0A401Q4Z6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0018118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012325">
        <property type="protein sequence ID" value="GCB80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4Z6"/>
    <dbReference type="STRING" id="75743.A0A401Q4Z6"/>
    <dbReference type="OMA" id="EGLQWTF"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17479">
        <property type="entry name" value="MFS_MFSD6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="18"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="639" mass="71080" checksum="41947457D4B6E097" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5A3</accession>
    <name>A0A401Q5A3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011008">
        <property type="protein sequence ID" value="GCB80554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5A3"/>
    <dbReference type="STRING" id="75743.A0A401Q5A3"/>
    <dbReference type="OMA" id="RARHKRH"/>
    <dbReference type="OrthoDB" id="125004at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021884">
        <property type="term" value="P:forebrain neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF117">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN LHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14479" checksum="2AD87C50BD3CB512" modified="2019-05-08" version="1">MLDNLQRAAENGNGVTVEGALPTEQDVVQPKPTKRARTSFTADQLQVWFQNCRARHKRHVSPNHLSTTPVTAAQQERVSPMLDEMTYSAYVAPDGQMLTALHTYMESHSPTSLGLRPLSSRAMTQLPIGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6I4</accession>
    <name>A0A401Q6I4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018633">
        <property type="protein sequence ID" value="GCB80961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6I4"/>
    <dbReference type="STRING" id="75743.A0A401Q6I4"/>
    <dbReference type="OMA" id="LAHMRPR"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF3">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CWF21" evidence="2">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="22138" checksum="26DD24EAAD3B412D" modified="2019-05-08" version="1">MYNGIGLPTPRGSGTNGYVQRNLSSVRHKKDRVDYKSEEELKKLESGLMKKPNQDILDHERKRKVELKCIELEDMMEEQGVSETHQLAEANEKKNERLRAAFGISDSYVDGSSFDPKRRAQEAVAKSEPQKQYGIVREPVRSRSPSPKRRKKKKARSRGRSASPSARSKEKKKKSSKKKSRSQSKSKSKKKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6S1</accession>
    <name>A0A401Q6S1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0022115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021280">
        <property type="protein sequence ID" value="GCB81079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6S1"/>
    <dbReference type="STRING" id="75743.A0A401Q6S1"/>
    <dbReference type="OMA" id="WPSETEI"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16559">
        <property type="entry name" value="RING-HC_RNF208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040100">
        <property type="entry name" value="RNF208_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF3">
        <property type="entry name" value="RING FINGER PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB81079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="233" mass="25828" checksum="1192574D4F606EAF" modified="2019-05-08" version="1">MEAVKIVPAEKFADCPSSQARYGPSQCVREPPLVGKCAWPLESEIIANQACTDVPTREKARSPSGLARTPPRREKFVQGHRKASAEMCYHRQTPSDEVIVNQYVLHQSTTSEPLECPTCGHVYNATNKRPRILSCLHSVCEECLQILYESCPKYKFISCPTCRRETVLFTDYGLAALAVNTSILARLPAEALTTNPGQWGGEADRSCYQTFQQYCGAACSCQLRNPLSSCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6T5</accession>
    <name>A0A401Q6T5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018709">
        <property type="protein sequence ID" value="GCB81114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6T5"/>
    <dbReference type="STRING" id="75743.A0A401Q6T5"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43807" checksum="C2E4817946B1403F" modified="2019-05-08" version="1" fragment="single">TGVKVYGCSLPDEGLDGSEEEEDEYQPENVTFAPKDVMMMDFTPKDDRHGLGYSGIDPSRALYGVAREDSITMFNTDSDRSSSLLGDVQSGKGRKLGITGQAFGVGALEEEDDDIYTRDTLSQYDTVLREEEPDDGLYGWTAPQQYKKKAKGLEPQMGYIGKVLEGFSLRSKSTKPKKVYGPPELPRDYRPVHYFRPVVAPGTVSTAMAQALGASEGQLRTEVGPKGRHQLNATQRRELLGEDALQGPRSVFELVSGKDKERLKDVQQQQAATPAPWDLSSQSQALASEGPRASQLAAVSGRRSTGSSEFKPFLKNPEKQKRYEEYVAKLQSGQSNALASSLDSNMTEWERDREQYEFGRAAVLYRPTSASLASRFTSPKFSEDTDKVEVPEQQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q782</accession>
    <name>A0A401Q782_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0021354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018773">
        <property type="protein sequence ID" value="GCB81232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q782"/>
    <dbReference type="STRING" id="75743.A0A401Q782"/>
    <dbReference type="OMA" id="DDICHLE"/>
    <dbReference type="OrthoDB" id="10072335at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF10">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN TEX28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB81232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="341" mass="39112" checksum="85765C68BD7137A3" modified="2019-05-08" version="1" fragment="single">MVHRFSLRKRRCSLQAEQSEVVRVPSPTPLTLSPDGSIISPLPEQHEDAALLEGLRAEQALLQQKVLKISEEIRVKQSHRSANTSEYLHLISHTDRAQAFRLKEAFEKKNQYLSAVISQLERRLESYVARQKQLEQDASLMRENASSLLTIDGLHRVRSDYNQDHLRPASPQPSEASTNLVVQSDADLPPSQTLHQRAFGAPFHNIDHMPLPDDEYSVITSFSEDFQDLLGLSFDTKSSRANSLERQNMGYLSMLEELTEIKETQINLELNFKNIAEQYNQHYAAFGESLHEEKYRSNQLQAQLNDLIDLHQNEVLNLKSELASLEEKIAYQSYESSRDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7K1</accession>
    <name>A0A401Q7K1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0021385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01018858">
        <property type="protein sequence ID" value="GCB81375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7K1"/>
    <dbReference type="STRING" id="75743.A0A401Q7K1"/>
    <dbReference type="OMA" id="QDAARNC"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="54"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB81375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="281" mass="32076" checksum="5306878667BB40E9" modified="2019-05-08" version="1" fragment="single">ESSAGVKHYHIREIDDALKRYYLAEKHVFDSIPELITYHQHNAAGTWEITATSLTFIEEVGCGQFGIVHMGYWKNKYQVAIKMIREGAMSEEDFIEEAQIMMKLSHEKLVQLYGVCTQDGPIYLVFEYMKHGSLSEYLRVNRGAFNKETLLGICQDAARNCLVGDSLSVKVSDFGMTRFVLDDQYTSSSGSKFPVKWSAPEVFRYSKFSSKSDAWSFGVLMWEVFSEGKMPYENRLNTEVVEELAAGFRLHKPKLASPLIYKIMSCCWLEVCVAIEKLACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8A5</accession>
    <name>A0A401Q8A5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galactosyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024234">
        <property type="protein sequence ID" value="GCB81608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8A5"/>
    <dbReference type="STRING" id="75743.A0A401Q8A5"/>
    <dbReference type="OMA" id="GAFWEFH"/>
    <dbReference type="OrthoDB" id="5971499at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008376">
        <property type="term" value="F:acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF46">
        <property type="entry name" value="N-ACETYL-BETA-GLUCOSAMINYL-GLYCOPROTEIN 4-BETA-N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10802" checksum="A276559F4659877D" modified="2019-05-08" version="1" fragment="single">DSHTILFLCDLHIHFPVSIIDNIRKHCIEGKLAYAPIVMRLGCGSSPREPDGYWEVNGFGLFGIFKSDFDKIGGMNTEEFRDRWGGEDWELLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Q3</accession>
    <name>A0A401Q8Q3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01028242">
        <property type="protein sequence ID" value="GCB81762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8Q3"/>
    <dbReference type="STRING" id="75743.A0A401Q8Q3"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="7730" checksum="D146F08905EB6FA8" modified="2019-05-08" version="1">MNAGHRHALLRGEFTNIPVDRSNVVRVFISSTFADMSMERDALLDKAFPDVQAFCQKLGLVFEVSETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8X2</accession>
    <name>A0A401Q8X2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0022574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023054">
        <property type="protein sequence ID" value="GCB81825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8X2"/>
    <dbReference type="STRING" id="75743.A0A401Q8X2"/>
    <dbReference type="OrthoDB" id="5987067at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048667">
        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000172">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-II" evidence="10">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB81825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10924" checksum="EB6426DC1D53FADF" modified="2019-05-08" version="1" fragment="single">FTVNGWPCVFPFRFSGKLHRTCISIKDTNRKWCAITPNFDKDGARDYCEEIEPLTHDYCEIHPCWHGAACINIPTEQSYQCICTDQFTGRDCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Y6</accession>
    <name>A0A401Q8Y6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025645">
        <property type="protein sequence ID" value="GCB81787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8Y6"/>
    <dbReference type="STRING" id="75743.A0A401Q8Y6"/>
    <dbReference type="OMA" id="TVMKGKH"/>
    <dbReference type="OrthoDB" id="29546at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="18567" checksum="330C955AF81551C9" modified="2019-05-08" version="1" fragment="single">EVYSKRVISIKSITQVSSVGDQKFEVITSNRTFVFRAESDGKRKRHKKEKDVRERQARERDARKRREKETRERERRERETDARKRREKETRERDARKRREKATQARDTRKRREKETDTRKRREKETRESDASKRHEKETRERDRHEKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAI2</accession>
    <name>A0A401QAI2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024721">
        <property type="protein sequence ID" value="GCB82366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAI2"/>
    <dbReference type="STRING" id="75743.A0A401QAI2"/>
    <dbReference type="OMA" id="NTVYEFW"/>
    <dbReference type="OrthoDB" id="6232067at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF6">
        <property type="entry name" value="FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="171" mass="18973" checksum="5B1CDA4F66F0F337" modified="2019-05-08" version="1">MYHTIRNLKPNTVYEFWVTATNSTGTSAQSERVKHTTVPLAPTINRRAVASCQDAALIEWESGSQNPACSYTVEFCQVCNGCDWRESLTESLTGITSCPTLIELEANENYLFYVRALNEGGCSERSSPINIRTTGKKTKTISDLSCVPGACHTFPAFHTGLKLRADRQRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAU7</accession>
    <name>A0A401QAU7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein POC5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein of centriole 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0022006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020822">
        <property type="protein sequence ID" value="GCB82490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAU7"/>
    <dbReference type="STRING" id="75743.A0A401QAU7"/>
    <dbReference type="OrthoDB" id="10064898at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042462">
        <property type="term" value="P:eye photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033351">
        <property type="entry name" value="POC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB82490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="146" mass="15086" checksum="CF56036E70D2A092" modified="2019-05-08" version="1">MSHHQVTLHFGTTNVAQTRLGEASTPPATITVASSASGFQSAQKLPPAKCVTSTQQNAGKTIVARITGRPDPSLKGVKCGSCQGVAPPMTTICVERHHPITQQTIGQGTAAKYPRSNQPPSGGKVTSQNAKSPTVSCGIQSIKVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAW9</accession>
    <name>A0A401QAW9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020857">
        <property type="protein sequence ID" value="GCB82528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAW9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7896" checksum="54D99B1838DCCB30" modified="2019-05-08" version="1">MKCGRSTTEREKMHEKELTGERSQVVVLFSLNSKGQKMIWKDREVPEKLWPHDTKEGEMSEHVVLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB27</accession>
    <name>A0A401QB27_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0022688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023534">
        <property type="protein sequence ID" value="GCB82556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB27"/>
    <dbReference type="STRING" id="75743.A0A401QB27"/>
    <dbReference type="OMA" id="HSMAETC"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051997">
        <property type="entry name" value="STK_NEK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535">
        <property type="entry name" value="PROTEIN CBG16200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB82556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="79" mass="8886" checksum="C25175835FE36330" modified="2019-05-08" version="1" fragment="single">DIKTLNIFLTKSDLIKLGDYGLAKQLNSLHSMAETCVGTPYYMSPELCQGEKYNFKSDIWAVGCVLFELLTLTRTFDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBF7</accession>
    <name>A0A401QBF7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0021680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM187 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019711">
        <property type="protein sequence ID" value="GCB82686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBF7"/>
    <dbReference type="STRING" id="75743.A0A401QBF7"/>
    <dbReference type="OMA" id="KTEIMIR"/>
    <dbReference type="OrthoDB" id="9899560at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF7">
        <property type="entry name" value="IG-LIKE V-TYPE DOMAIN-CONTAINING PROTEIN FAM187A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="272"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB82686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="410" mass="47798" checksum="DBCCDE03E595E5D4" modified="2019-05-08" version="1" fragment="single">VVLSFGPFLWPALIHASEFVIEEKEDIFKIQSCPAFLMFQNAAYLADMTFELPCLCKPEDVTSVVWYYQKDLGKGHTKVLSDFHGTKILDASQLRAGLDIQSRFRILMFSLLVLNAQPQDSGHYMCGSVKGDYFYGYDIDVQSYKNAHITFKEKEEKPMLDVETKTYKVFTSYWNWTVCDRCGVRGEQRRIGLCYIRSPYLYFRYKKILTNVVSCGSGAVPRRYQHILKKRKTEIMIRSCFVPCATRYPSIEGEKFIFDVFGFTNDKNKKTPQVPVQTHIHAIGYPLTIACPDARAEHAVAWDKGRRPLYREEYMVGVNRSMRLYIDQGNHLVFRAIQLNDIGTYYCWREGQLMAGIRLRIGLPPRIHRNFTDEESIFAMQTILSTYFILTLIFIFLKCMKCCNYYFDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCJ8</accession>
    <name>A0A401QCJ8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034145">
        <property type="protein sequence ID" value="GCB83037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCJ8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="53" mass="6477" checksum="F3DE3D8F27867601" modified="2019-05-08" version="1" fragment="single">LFPESENVTKLQIRHQEKVNRLYQENGEFAQEVFELNKQRKRKEMELQATQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCU4</accession>
    <name>A0A401QCU4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
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            <dbReference type="PubMed" id="30297745"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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            <dbReference type="PubMed" id="30297745"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB84441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="44" mass="5051" checksum="5863F09A1A2322C5" modified="2019-05-08" version="1" fragment="single">MSADRVVSFMDQIRIFQDQVEKLKVLQVDSAEYSCLKAIALYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGN0</accession>
    <name>A0A401QGN0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0025079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01070411">
        <property type="protein sequence ID" value="GCB84503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGN0"/>
    <dbReference type="STRING" id="75743.A0A401QGN0"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB84503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9001" checksum="C49984090D4E28A1" modified="2019-05-08" version="1" fragment="single">LVPPKKDGNFVRINLKKKSHVKGGVLRGAYLRKQAWKQKLQMKGERFGGGGGRFNRSGDTCFRCGATGHWAKNCRGKGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH59</accession>
    <name>A0A401QH59_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01096282">
        <property type="protein sequence ID" value="GCB84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH59"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="144" mass="15103" checksum="4F61B83785CD5028" modified="2019-05-08" version="1">MAAKCITREHSAAKGIARTHNNPAAKSSGREHNNAAAKSIARAHNDAAAKSIAREHNNAAKSIARAHKNAAAKSTGRAHNNAAAKSMVRAHNAAAKSIVRAHNNAAAKNIARAHRAAKCIAREHNNAAAKSIVRAHTMQQQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHQ1</accession>
    <name>A0A401QHQ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01106604">
        <property type="protein sequence ID" value="GCB84863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHQ1"/>
    <dbReference type="STRING" id="75743.A0A401QHQ1"/>
    <dbReference type="OMA" id="RTRCHNC"/>
    <dbReference type="OrthoDB" id="10063284at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="198" mass="22564" checksum="C7B4A6F710DF3B7F" modified="2019-05-08" version="1">MGAIELIAEFDPFLHEHLEKCRNEKVNATYLSKPMYEELIEIMGKHLQDEIVNQINNRDTKYNSIIVDSMPDLTHVAQLVIVVRYCYNGKPCERFLTFLPIENHSSTTLFNKIQQVQGEHKVSLENIRGQSYDNASNMKGSEKGLQALFKNINRYADYVPCAAHSLNLVGEKAVSTVPEVVDYFGILQELYVFFSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIS8</accession>
    <name>A0A401QIS8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01146730">
        <property type="protein sequence ID" value="GCB85280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIS8"/>
    <dbReference type="STRING" id="75743.A0A401QIS8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="225" mass="24694" checksum="6451404304CD52A1" modified="2019-05-08" version="1">MGLTVQRAQWEWDVLVSEHSGEWDSLVSERSGEWDLLVSEHSGEWDPLVSERSGEWDLLVSEHSGESDSLVSERSEEWDLLVSEHNGAWDSLVSEHSGEWDSLVSERSGEWDLLVSELNGESDSLVSERSGEWDLLISEHSGEWDLLVSECSGDGDSLVSERNGECDSLVSEHSGESDSLVSECSGQWDLLVSEHSGEWDLLVSEHSGNGTCLSVSTVGMGLAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIT6</accession>
    <name>A0A401QIT6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01141578">
        <property type="protein sequence ID" value="GCB85283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIT6"/>
    <dbReference type="STRING" id="75743.A0A401QIT6"/>
    <dbReference type="OMA" id="DHTLIDH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="18922" checksum="C5D830A214E689D6" modified="2019-05-08" version="1" fragment="single">LIDHTLIDHTLIDHTLTDLTLIDHTLSDHTLIDHTLTDLTLTDLTLIDHTLSDHTLSDLTLSDHTLTDHTLSDHTLIDHTLIDHTLSDHTLSDHTLIDHTLIDHTLSDHTLSDLTLIDHTLIDLTLIDHTLIDHTLSDHTLIDHTLIDHTLTDHTLIDPMGWSMAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIY6</accession>
    <name>A0A401QIY6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01144755">
        <property type="protein sequence ID" value="GCB85328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIY6"/>
    <dbReference type="OMA" id="REPDEVC"/>
    <dbReference type="OrthoDB" id="6161911at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="223" mass="23674" checksum="48A167AA2CE08AF4" modified="2019-05-08" version="1">MAVVHSAASRDSVTGKSVGAEEEAIPSSDSRSRSDSRSGSDSSSDSSSDSDEETVTEDAGKSAAELPKRLPIHSSPGRAAEQTRERKEVERGGLVREPDEVCQDVNVPESKDSTSTGVSTCEERKAQTGHRESTRQGNRMMASSEICAGDKATVTTPGARSLPITKPVTEESTASSSLKEWLLPAPGERPEPEHKWAKEGTPEAGVPDMAAMPQGTRLFPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKM9</accession>
    <name>A0A401QKM9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0026625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01221195">
        <property type="protein sequence ID" value="GCB85939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKM9"/>
    <dbReference type="STRING" id="75743.A0A401QKM9"/>
    <dbReference type="OMA" id="KMRCFEP"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF52">
        <property type="entry name" value="CYSTEINYL LEUKOTRIENE RECEPTOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB85939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="330" mass="36943" checksum="1FA050DD7C580D24" modified="2019-05-08" version="1">MSSPSENQNTSDCRSDDFKLPVFIAADSVILPIGVIGNTLALYVCARLIRRRTASTDFMINLAVSDLLFNLTLPYRIVYYSQREWTLSDFLCPVTIYAFSLNLYCSIFFLMALSVFRYVAVLHPLRSKSIGTVRRALCVSLAICVRLARVPFLCVLPIVGDGKRRCFEPSIVSWGHILQVNYVGLAFGFLIPFLVIVVCYTRITQRLRESAGTVPRAVRSHKRSIYLVAFVLGCFVFCFLPYHIIRTVHLHLLTAQQRDCPNVPGAIQKLIVVTICLAAANSCLNPLLYYFAGENFRSSVRMAKIFRMRSACSGSAACRECSTATSLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM13</accession>
    <name>A0A401QM13_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01292850">
        <property type="protein sequence ID" value="GCB86461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM13"/>
    <dbReference type="STRING" id="75743.A0A401QM13"/>
    <dbReference type="OMA" id="YPPETCT"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="187" mass="20055" checksum="B3D573AB011C2006" modified="2019-05-08" version="1" fragment="single">GETETMPRETERVPGETETMPGETDTVPEGTLIAPGETETMPGETERAPGETETMPGETETMPRETERVPGETETMPGETETMPRETGRVPGETETMPGETETEPGETETMPGETERVPGETENMPGETDTVPEGTVIAPGETETMPGETDRAPGETETMPRETEILPGETETEPGETETVPGETET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QME9</accession>
    <name>A0A401QME9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01312718">
        <property type="protein sequence ID" value="GCB86554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QME9"/>
    <dbReference type="OrthoDB" id="10062493at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="77" mass="9291" checksum="9FDA2B687F3EFE0C" modified="2019-05-08" version="1" fragment="single">MPVRIELERPVQTELEMPLRIKLETPVRIKLETPVRRELETPVRIELERLVRIKLETPVRRELETPVQTELEMPVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A387LBN1</accession>
    <name>A0A387LBN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Forkhead box protein G1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">StFoxG1</name>
        <name evidence="8" type="ORF">scyTo_0009274</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="LC427855">
        <property type="protein sequence ID" value="BBG57206.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAA01003743">
        <property type="protein sequence ID" value="GCB61053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A387LBN1"/>
    <dbReference type="STRING" id="75743.A0A387LBN1"/>
    <dbReference type="OMA" id="AHPMSYS"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20021">
        <property type="entry name" value="FH_FOXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047208">
        <property type="entry name" value="FOXG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="101"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="101"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BBG57206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB61053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="409" mass="44824" checksum="5FE6B69D1E3FE0ED" modified="2018-12-05" version="1">MLDMGDKKEVKMIPKSSFSINSLVPEAVQSDNRHRSAPEQEDKNILPTLESKSENTLSKSDNSSAEPPCSEDKEKQEEKKVDGKEGDAGKEGEKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWPVSPFLSLHHPRASSALSYNGTTSPYPSHPMSYSSVLTQNSLANNHSFPTSNGLSVDRLVNGEIPYATHHLTAAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTSQSSTSMTARTASSTSPQAPSTLPCESLRPSLPSFSTGLSAGLSDYFTHQNQGPSSNPLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGM7</accession>
    <name>A0A401NGM7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004873">
        <property type="protein sequence ID" value="GCB59871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGM7"/>
    <dbReference type="OMA" id="DHLDICA"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019422601" description="SEA domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB59871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="52399" checksum="FE98D4952BAC826F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHV1</accession>
    <name>A0A401NHV1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium/calmodulin-dependent protein kinase II inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAMK2N family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006252">
        <property type="protein sequence ID" value="GCB60448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHV1"/>
    <dbReference type="OMA" id="MSEIMPY"/>
    <dbReference type="OrthoDB" id="9922824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008427">
        <property type="term" value="F:calcium-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026779">
        <property type="entry name" value="Camk2n"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31007">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31007:SF1">
        <property type="entry name" value="CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE II INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15170">
        <property type="entry name" value="CaM-KIIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="79" mass="8742" checksum="7ED4CADD9FCE58F6" modified="2019-05-08" version="1">MSEILPYSEEKMAHFGGEGEVGQLSFSCRLQDTNTFFGGSQPKRPPKLAQIGRAKRVVIEDDRIDDVLKGREDKTSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIH9</accession>
    <name>A0A401NIH9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004995">
        <property type="protein sequence ID" value="GCB60676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIH9"/>
    <dbReference type="STRING" id="75743.A0A401NIH9"/>
    <dbReference type="OMA" id="EGLCGVT"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000019">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF23">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="204" mass="23240" checksum="5F7E32ABE2B1087C" modified="2019-05-08" version="1">MAEPKWKRQKTCLPICSFHQPAPGSQVKQNYPESVEEAVCGLITLFYQVSYRFQALAEIFEQNDVALPRVSGYFQKVADEEEHNAEILLEYQKERGGHYCAKDIKKPSTESVQNMRQALDQTIQQWKTVATFLEELCALSKSCTDPHTTSFIRKRLLVPKIQQIKVAGDLITNATRLGCTDEGQVSFGEYLIDRLQEELQKPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIJ9</accession>
    <name>A0A401NIJ9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002417">
        <property type="protein sequence ID" value="GCB60696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIJ9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="60" mass="6558" checksum="9A3AB7FDA5EBB6F4" modified="2019-05-08" version="1" fragment="single">NSRPPYATQAYSPGKGDLIPGCAMVSAKQPGLEVVLLCTDLNWFLIFIEEEVHFSLSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIP1</accession>
    <name>A0A401NIP1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006296">
        <property type="protein sequence ID" value="GCB60740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIP1"/>
    <dbReference type="STRING" id="75743.A0A401NIP1"/>
    <dbReference type="OMA" id="HECECLS"/>
    <dbReference type="OrthoDB" id="9391002at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051375">
        <property type="entry name" value="Tuftelin_GRINL1A/MYZAP/CCD68"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171">
        <property type="entry name" value="GDOWN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB60740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="48435" checksum="3C98F967FCB2B1FC" modified="2019-05-08" version="1">MIAYCSLRDELFYLVNNQMANINLIRGCALIGLFHTVWSGITFLSEVKRKKSHLIARNYRLHLYCTTMYCTKPRMVESNSHEEGGRKLYYGSATAQIKEETEYIKKMRITLQKMRQQLFGNEDGVIDSQQTQEIKRPAMESSEVNESEPCVVDLCSKYRQTLDQIKAKDAQLRAIQWENKELLIKLEATQEAGTAAIRNASEKLFKHYQKQMDELRQQHEEEKRKLQTFAEEQGKNLERSVENYNNLELSLQQKQNRAMELEKLIERMEKEKKELVERKQSVEKKMEFEESTSMDVPDNRMRFQDHQLEVSTLQEKIFHLDAVVIQQHRNLYSVINTIENLKTDLTKQDQIILSLREQVGQLEAENKELKYKAEHYVNKQSKNASPVPCTSYESPRNKTPYQMLMKWKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIQ5</accession>
    <name>A0A401NIQ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0003993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001139">
        <property type="protein sequence ID" value="GCB60743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIQ5"/>
    <dbReference type="STRING" id="75743.A0A401NIQ5"/>
    <dbReference type="OMA" id="RMQNTTT"/>
    <dbReference type="OrthoDB" id="10046764at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08031">
        <property type="entry name" value="LARP_4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12706">
        <property type="entry name" value="RRM_LARP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034900">
        <property type="entry name" value="LARP4B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF43">
        <property type="entry name" value="LA-RELATED PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB60743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="771" mass="86092" checksum="E6145ECFDC650E18" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJW9</accession>
    <name>A0A401NJW9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transthyretin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0012873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the transthyretin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006364">
        <property type="protein sequence ID" value="GCB61201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJW9"/>
    <dbReference type="STRING" id="75743.A0A401NJW9"/>
    <dbReference type="OMA" id="PFYHHAD"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070324">
        <property type="term" value="F:thyroid hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.180:FF:000002">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF12">
        <property type="entry name" value="TRANSTHYRETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0372">Hormone</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0765">Sulfation</keyword>
    <keyword evidence="8 9" id="KW-0795">Thyroid hormone</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB61201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="125" mass="13863" checksum="9BF4C30DE036C238" modified="2019-05-08" version="1" fragment="single">DHGASDTQCPVIIKVLNAVNGTSAANLHMQIYRRSEDLSWQQLNTGVTGVNGEVHDLATEADFVPGLYKVHFNTADYWRALGYVSFHECVNVIFRVDASAHQHYTLALLLSPYSYSTTGVIRDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK70</accession>
    <name>A0A401NK70_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">carbamoyl-phosphate synthase (ammonia)</fullName>
            <ecNumber evidence="5">6.3.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0009304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01003770">
        <property type="protein sequence ID" value="GCB61260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK70"/>
    <dbReference type="STRING" id="75743.A0A401NK70"/>
    <dbReference type="OMA" id="FCHETIS"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000012">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000006">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="496"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB61260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1131" mass="123943" checksum="48E5F546E31B59ED" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM63</accession>
    <name>A0A401NM63_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase III subunit RPC5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006472">
        <property type="protein sequence ID" value="GCB61950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM63"/>
    <dbReference type="STRING" id="75743.A0A401NM63"/>
    <dbReference type="OMA" id="NEMDWAK"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045576">
        <property type="entry name" value="RPC5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19725">
        <property type="entry name" value="RPC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC5 C-terminal" evidence="2">
        <location>
            <begin position="445"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="703" mass="79257" checksum="384D184F27A0F97D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMB3</accession>
    <name>A0A401NMB3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0004190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001221">
        <property type="protein sequence ID" value="GCB62016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMB3"/>
    <dbReference type="STRING" id="75743.A0A401NMB3"/>
    <dbReference type="OMA" id="KHAPNDY"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="461" mass="50538" checksum="6F0459DBE7808A2D" modified="2019-05-08" version="1" fragment="single">EEQLAHLWEWSLAIRKIEVARDFQKMPSQRAAVGNAEYKVVPHTRVDDEFAIRQIYSFGQRLGQGSYGVVIEATHNGTGKKWAIKKVNREKAGSSGVKLLEREVSILKLVDHEHIIHLEEVFETPKRVYLVTEVCEGGELSAILHRKKRLSEKETRHLGLCKVTDFGLSVQKGGVGSDKMLQATCGTPLYMAPEVLSAHQYTQQCDTWSIGVIMYTLLSGDPPFVANSEEKLAELVNKGELHFDDSVLQEISDGAKDVLSRLLKVDPAHRITANELLDNPWVTGDTTATQRPSNVLEMMKQWRDDLDGDEEGSSTNSSLPSSIFQNMQTSQEAGGSSTSSNGTSSSSRAIDTGETQSCIPAKQSLKKNTLASFSVDGSVLTKKTNKFSSNPHGSSKASPKLSMKRTPLQDKRTWSPTHLIPPVRSGAISGKPGVRRSITPTGDGSGCKYTNKSTPKTKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMP3</accession>
    <name>A0A401NMP3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ski oncogene</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001229">
        <property type="protein sequence ID" value="GCB62143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMP3"/>
    <dbReference type="STRING" id="75743.A0A401NMP3"/>
    <dbReference type="OMA" id="PIGDWIS"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF15">
        <property type="entry name" value="SKI ONCOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB62143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56879" checksum="AFD6D0E380D5CF37" modified="2019-05-08" version="1">MCRVFTLADRKKRAEKKKKKGNKVQSVKPIGDWISKDWLNQHLLEEIFFRDYTAKEEKARLEQLLDEMKERFDYSNKYKRKAPRVPFDQTVFKKFKQDETASESLAASEKEKQPEWWRCFSSPSSTKNVLSSSCVHSQQRLSAFRPWSPTISTSEKETLTHLPALARDSFYAYKSYEGSVAPNVALTPLPQQRNGRPSPSATAVTHNIPTPSEVNRPRKRRTTADLQLEQETAAPLAAVFPAEDKDSDAEVEVESREGFTSSLSSLSSPSFTSSGSSAKDLSSPGVQVASSGVFENPGHTDMHNSGLEVELEHLRQALDNGIDTKEAKEKFLHEIIKMRVKQEEKLNAALQAKRSLQQELEFLRVAKKEKLREATEAKRNLRKEIERLRAEGEKKMKEANESRIRLKRELEQAKQIRVCDKGCEAGRLRIKYSAQIEELQVKLQHAEADREQLRADLLREREAREHLEKMVKELQEQLWLKPSNSTTSKVVSKDSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRB7</accession>
    <name>A0A401NRB7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Dynein heavy chain 5, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0004418</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001313">
        <property type="protein sequence ID" value="GCB63443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NRB7"/>
    <dbReference type="OMA" id="REWEAYI"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF13">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="16">
        <location>
            <begin position="269"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal heavy chain 2/5/8 coiled-coil" evidence="19">
        <location>
            <begin position="1117"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="17">
        <location>
            <begin position="1273"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1719"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="907"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB63443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2061" mass="237611" checksum="135088D6013E3C89" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS54</accession>
    <name>A0A401NS54_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0009702</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004036">
        <property type="protein sequence ID" value="GCB63690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS54"/>
    <dbReference type="STRING" id="75743.A0A401NS54"/>
    <dbReference type="OMA" id="YNATIPR"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008361">
        <property type="entry name" value="MCH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008362">
        <property type="entry name" value="MCHR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF88">
        <property type="entry name" value="MELANIN-CONCENTRATING HORMONE RECEPTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01784">
        <property type="entry name" value="MCH2RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01783">
        <property type="entry name" value="MCHRECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB63690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="292" mass="33291" checksum="665F235FB0720BDB" modified="2019-05-08" version="1">MDLHTGGGRLSVQKTIPDIYICNLAVADLVHIIGMPFLIHQWAQGGEWVFGSTLCTIITSLDNCNQVSCCAIMTAMSLDRYLALVHPFRLTSFRTRSKTIKINLCLWAISLVLALPVWTHAKVIKFKDGLESCAIDLTSPQDILWYTLYQTLTTFFFPLPLILICYILILCYTWDIYQENKRTGRYNATIPRAQLKRLTKMVLVLVSIFVVSSAPYHVMQLVNLEVTQPTTAYFIGYYISICLSYASSSINPFLYILLSVNFRRRLCGCTKIQLKLTERELINIESTVKLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTZ2</accession>
    <name>A0A401NTZ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004095">
        <property type="protein sequence ID" value="GCB64363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTZ2"/>
    <dbReference type="STRING" id="75743.A0A401NTZ2"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB64363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8439" checksum="34E19EEECCD9D12B" modified="2019-05-08" version="1">MAASLLGSIRVLRAALSPRKLPLATVPRLGRCRYLVTSQRLLGVAPLQVLMPALSPTMEKGNIVKWLKKEGKPQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUC9</accession>
    <name>A0A401NUC9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0014775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Xin repeats bind F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Xin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008055">
        <property type="protein sequence ID" value="GCB64469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NUC9"/>
    <dbReference type="OMA" id="ADRKKTM"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012510">
        <property type="entry name" value="Actin-binding_Xin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030072">
        <property type="entry name" value="XIRP1/XIRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22591">
        <property type="entry name" value="XIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22591:SF2">
        <property type="entry name" value="XIN ACTIN-BINDING REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08043">
        <property type="entry name" value="Xin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51389">
        <property type="entry name" value="XIN"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="846"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1095"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1483"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1528"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1756"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1808"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1915"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2142"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2512"/>
            <end position="2535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2604"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1487"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1540"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1857"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1872"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1942"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1959"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2011"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2036"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2059"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2088"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2159"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2516"/>
            <end position="2527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2636" mass="293279" checksum="6150194191AB920F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUI3</accession>
    <name>A0A401NUI3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cbp/p300-interacting transactivator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0014784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CITED family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008067">
        <property type="protein sequence ID" value="GCB64551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUI3"/>
    <dbReference type="STRING" id="75743.A0A401NUI3"/>
    <dbReference type="OMA" id="PSHHMSA"/>
    <dbReference type="OrthoDB" id="10025072at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2200:FF:000001">
        <property type="entry name" value="Cbp/p300-interacting transactivator 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007576">
        <property type="entry name" value="CITED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17045:SF8">
        <property type="entry name" value="CBP_P300-INTERACTING TRANSACTIVATOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17045">
        <property type="entry name" value="MELANOCYTE SPECIFIC GENE RELATED CITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04487">
        <property type="entry name" value="CITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB64551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30102" checksum="421860CA96316279" modified="2019-05-08" version="1">MLLLIHIPERIRAQLRVGGAMADRMMMSHGRFAEGSNGLHVRRMGLSPYPQHQHAYSGLMSEHPAAATTSLLHYPGPSNVNSGGGMRHAMVPGSVSRQAAVGHLSNMPPNIRYASRQQQQQQPPHHSHPPHPQYMGPPVTSSNTSSPAAQLAASMHLQKLTNQYYGHQQHYSLTDLHPASALSHQQQQQQQYREIKHHSPSVPPSHHMSATILPPNVIDTDFIDEEVLMSLVIELGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUM5</accession>
    <name>A0A401NUM5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008066">
        <property type="protein sequence ID" value="GCB64542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUM5"/>
    <dbReference type="STRING" id="75743.A0A401NUM5"/>
    <dbReference type="OMA" id="HNWIANT"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="382" mass="35279" checksum="A6C83AE8D91CED9C" modified="2019-05-08" version="1" fragment="single">MLAAVAGAAALHAALWQHRRRQLREAAAAAAAAERQAAAEGQAAAEGQAAEGQAVAEGRAVAEGRAAAEGQAEAEGRAAAEGQAAAEGQAAAEGQAVAEGQAAEGQAAAEGQAAEGQAAAGGQAAAEGQAVAEGQAAAEGQAVAEGQAAAEGRAAAEERAAAGGQAAAEGRAAAEGQAAEGQAAAGQAAAEGQAAAEGKAAAEGQAAEGQAAEEQAAAEGQAAEGRAAAEGRAAAEGRAAAEGQAAEGQAAEGQAAEGQAAAGRAAAEGQAAEGQAAAGQAAAGQAAAEGQAAAEGQAAEGQAAAEGQAAAEGQAAEGQAAEGQAAALGQAAAEGQAAEGQAAAEGRAAEGQAAAEGQAAEGQAAGLHARRAQEEEEDDNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVT8</accession>
    <name>A0A401NVT8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing regulatory glutamine/lysine-rich protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Serine/arginine-rich-splicing regulatory protein 86</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Splicing factor, arginine/serine-rich 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0014839</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008123">
        <property type="protein sequence ID" value="GCB64998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVT8"/>
    <dbReference type="STRING" id="75743.A0A401NVT8"/>
    <dbReference type="OMA" id="MYPADEF"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12260">
        <property type="entry name" value="RRM2_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000084">
        <property type="entry name" value="Serine/arginine-rich splicing factor 11 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000142">
        <property type="entry name" value="splicing regulatory glutamine/lysine-rich protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034192">
        <property type="entry name" value="SREK1_RRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF71">
        <property type="entry name" value="SPLICING REGULATORY GLUTAMIC ACID AND LYSINE RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="180"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB64998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="417" mass="45624" checksum="5034C139D86991C6" modified="2019-05-08" version="1">MSTSVVQVTNISPVASSEQLTTLFSFLGEIEQFRIFPSDNSPIPVSSRVCYIKYHDPVSVGVAQHLTNVVFIDRGLIVVPFREGKIPDETKAVSLLAPATPTGLLSGAGLLPIPTSNPLASITTVDAVTSTMGAVVASVPFTTLGALQAGLDPALTALGLNSQPPTMGNVDPTKIEEIRRTIYVGNLNSQTTTADQLLEFFSQVGEVKFVRMAGDETQPTRFAFVEFAEQPSVLRALAFNGAMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAVIEPVAEKESDDKNRRSRSYSRSRKKRSRSSSKQRSSRSRSQHRSPSRQNDKRDSKSPPAKRSQSKDRRQSKSCSPPREKATESDSKGKEEEEENKDGNGDNGKKKEKKSSTQQEKNSASRKSRSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWM4</accession>
    <name>A0A401NWM4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001426">
        <property type="protein sequence ID" value="GCB65268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWM4"/>
    <dbReference type="STRING" id="75743.A0A401NWM4"/>
    <dbReference type="OMA" id="ETIWDHT"/>
    <dbReference type="OrthoDB" id="9927094at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB65268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37114" checksum="D026CFD6A2182AEB" modified="2019-05-08" version="1">MVRTGLNGHCVGYEARDRPDIWISKYPIKHGIVTNWDDMEKIWGHIFNTELQVDPAEYSVLLTEAPLNPKINREKMIQLMFERFATLGFYIAVPGVLSIYATGRIGGLVLDSGDGVTYALPVNDGYMVPGSIRRLNFGGRELTDYLLESLIHHGCHFSMPAERLIAENIKEKLCYVALDYDQETVMIAATSSRDKSYELPDGQILMIKNECFQCPEALFQPSFLGMPSAGVHETANDSIEACESCLRSDLYANIVLAGGSTMFPGFADRMQKEITALAPNTMKIKVLSPGERKYSVWIGGSIVASLSTFQQMWITKKEYEESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWN1</accession>
    <name>A0A401NWN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004185">
        <property type="protein sequence ID" value="GCB65278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWN1"/>
    <dbReference type="STRING" id="75743.A0A401NWN1"/>
    <dbReference type="OMA" id="AVELECY"/>
    <dbReference type="OrthoDB" id="6480633at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000014">
        <property type="entry name" value="Membrane cofactor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF15">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="195"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="197"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="257" mass="28058" checksum="7D17B927CE85AFE7" modified="2019-05-08" version="1">MAAWVARVTGQCGTPPMLPNGFLAEKFSSMTSFPVATIVYYACYPGYSLKEGSSKTITCLEGSTWGPIQTSCEPRNCGNPGEILNGYYRAADGTTLGKKVYFFCDEGYLIVGRDYRVCVADGWDGQVPRCDMVSCDYPASISNGKVTAPPKGDTWTSGMVAQYSCNGDYSLIGEEQLTCTISGKWDKAPPKCKVVQCQRPPDPANSNAVNGFGPTYKYHDSITYRCKDGYEMVGANVIRCNETSMFEPSPPICRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYV7</accession>
    <name>A0A401NYV7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008239">
        <property type="protein sequence ID" value="GCB66044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYV7"/>
    <dbReference type="OMA" id="KFQPENR"/>
    <dbReference type="OrthoDB" id="9947543at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="237" mass="27325" checksum="38E3FB971B544D30" modified="2019-05-08" version="1" fragment="single">TQCSNQINDQKELYEEQIKDLNQKLADVTKFQPENRNTEAADESKSLIKQKPTEKKGSTEPSNKEQTSPRQITDHTDQLKVEKTNELKHGDKRIKEFKHVTISTHLAQELENNKLVDADIHEDENKTKVDYENAESRKTPGLSNEWPTGQMWSTKTPGVIPRDGFQITDDENQNQKNLLDLLKGKQMKDYNGDEGNVAEPENDKEEELTSDIKGRHNKETKNRILEQNEGDNMRQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYZ8</accession>
    <name>A0A401NYZ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin-protein ligase E3A</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">HECT-type ubiquitin transferase E3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Oncogenic protein-associated protein E6-AP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0011950</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01005627">
        <property type="protein sequence ID" value="GCB66093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYZ8"/>
    <dbReference type="STRING" id="75743.A0A401NYZ8"/>
    <dbReference type="OMA" id="GDCTNEF"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030518">
        <property type="term" value="P:nuclear receptor-mediated steroid hormone signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000008">
        <property type="entry name" value="Putative ubiquitin-protein ligase E3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF10">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HECT" evidence="19">
        <location>
            <begin position="543"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB66093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="871" mass="99738" checksum="58A5B14E87EF8EF5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZH8</accession>
    <name>A0A401NZH8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Hexosyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0007846</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14389"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:134090"/>
            <dbReference type="EC" id="2.4.1.149"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with B3GNT8; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="EMBL" id="BFAA01002919">
        <property type="protein sequence ID" value="GCB66264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZH8"/>
    <dbReference type="STRING" id="75743.A0A401NZH8"/>
    <dbReference type="OMA" id="VSHLNYC"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008532">
        <property type="term" value="F:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030311">
        <property type="term" value="P:poly-N-acetyllactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000010">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF25">
        <property type="entry name" value="N-ACETYLLACTOSAMINIDE BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB66264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="395" mass="45957" checksum="2350181FDEAE1758" modified="2019-05-08" version="1">MSVGRKRTKLVGILMMVNFFIYIVVEISRSGHQDTNSSKKMIISNSVFWKPLVHIKPYWNREQHKLDELYNPITAALHNRTVMENLNITTMFTCEPNAQLKDEISNFDSLPDRFKDFLTYLRCRSYPLIIDQPTKCQNKPVLLLAIKSLESHFDRRQAIRQSWGNEGTIGNKTVARIFLLGKSSPADDFPNLSNMLKFESNQHRDILLWDYRDTFFNLTLKEVLFLEWVSKSCSDIQYIFKGDDDVFVNTVQILEYLNTLDKDKAKDLFIGDVITNAGPHREKKLKYYVPESIFEGVYPPYAGGGGFLYSGYLAKRLHNVSYQVALYPIDDVYTGMCLRKLGLAPEKHKGFRTFDILQKDRHVTCAYKNLILVHSRNPQEMIRIWSRLQDPKLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P033</accession>
    <name>A0A401P033_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0012012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01005669">
        <property type="protein sequence ID" value="GCB66464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P033"/>
    <dbReference type="STRING" id="75743.A0A401P033"/>
    <dbReference type="OMA" id="KANFFEH"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="361" mass="41783" checksum="B8BA27440FB32A55" modified="2019-05-08" version="1">MSHRAHLIPHNLISASLSVSLPKEEENRVDLKDSKAAKLQNEPLLQGNPNRFVIFPIQYHDMWQMYKKAEASFWTAEEVDLSKDFAHWASLKQEEKHFISHVLAFFAASDGIVNENLVERFSHDVQITEARCFYGFQIAMENVHSEMYSLLLDAYIKDPNEREFLFNAIETMPCVKRKADWALQWIADREATFGERLVGFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLFKHLVHKPSEERVREVISEAVKIEQEFLTESLPVDLIGMNCTLMKYYIEFVADRLLLELGFSKIFKAKNPFDFMENISLEGKTNFFEKRVAEYQRMGVMSKAEDNHFTLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P119</accession>
    <name>A0A401P119_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002966">
        <property type="protein sequence ID" value="GCB66797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P119"/>
    <dbReference type="OMA" id="EITEWVN"/>
    <dbReference type="OrthoDB" id="9934306at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031677">
        <property type="entry name" value="TEX38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15834">
        <property type="entry name" value="THEG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="289" mass="32786" checksum="DF1B664466CCCFD3" modified="2019-05-08" version="1">MLNCRAGRARAQIRCLRQRRAGNVIRIDAVIHTNWVCPFFITFGACMILATVTCCLFHLRKTRNRKKEITEWVNAMKFGGKVYHPLLHWIKNNSDLSIKTRVYCSANEECKKRKVWKTRTILPVRYKKITEEASELNREAGDCNNMQIGNKPFPKSPVYVTSGEVSSLYSLINSEQANCRPSLNTEKYRQQVFPNSLSLYEKCAAIHQYVMESDEQQSVIACPDVNDPFSSSANQQCSNSISTRLSDFEVAKREVSTVKQGRCKASVLSESNSVAQKSHVFSVPDTVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1Y4</accession>
    <name>A0A401P1Y4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001552">
        <property type="protein sequence ID" value="GCB67159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1Y4"/>
    <dbReference type="STRING" id="75743.A0A401P1Y4"/>
    <dbReference type="OrthoDB" id="8921166at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002764">
        <property type="term" value="P:immune response-regulating signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050412">
        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738">
        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738:SF186">
        <property type="entry name" value="OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16555" checksum="DC66746283B8D6D4" modified="2019-05-08" version="1">MSEFERSIIFTIKELTPQDAGTYSCSFVKAVKGTEYETPRSDTVTFNVTEKLPRATISVDPTSGVVSRGKPIRLTCIGAILPSGGRFYFYRDDNKKGTLDVSGAVHAASFIVNDMVNTGKWNYTCGYARIVQQIAYHAPRSIAVQVTMAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2S4</accession>
    <name>A0A401P2S4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UGGT thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008412">
        <property type="protein sequence ID" value="GCB67407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2S4"/>
    <dbReference type="STRING" id="75743.A0A401P2S4"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10551" checksum="1C4B569B6293D538" modified="2019-05-08" version="1" fragment="single">TNTTVLEEDDDIDEVQGFHFKKLKHLFPDLNDQLKELRKHLIESTNDMAPLKVWELQDLSFQAASRIVSTSVHDALKSMRELSQNFPTKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P353</accession>
    <name>A0A401P353_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000150">
        <property type="protein sequence ID" value="GCB67530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P353"/>
    <dbReference type="STRING" id="75743.A0A401P353"/>
    <dbReference type="OMA" id="DKQLHFF"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB67530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="296" mass="33847" checksum="2479CD73192CDC0D" modified="2019-05-08" version="1">MNMFPDNVVTKELSTAFRKDGFVAIEGFFTVAECDSLRARISDIIDEMEVPQELQTQFSTQETEQIQTQGTKEYFLTSGDKIRFFFEKGVFDDKGDFLVPKEKSLNKIGHALHALEPTFKNLTHSRKVQEVAQMLELKQPVILQSMYIFKQPGIGGEVMPHQDASFLHTEPLGRVVGFWIAMEDATEENSCLWFIPGSHNSGITRRMLRAPKGDFPLLTFIGMERDYPDDDFIPVPVKKGGLILIHGEVVHKSGPNTSDKSRHVYTFHLMESQDCHWSEDNWLQPTPELPFQRLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3E1</accession>
    <name>A0A401P3E1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleophosmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0012171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoplasmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005793">
        <property type="protein sequence ID" value="GCB67638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3E1"/>
    <dbReference type="STRING" id="75743.A0A401P3E1"/>
    <dbReference type="OMA" id="DDRMAHQ"/>
    <dbReference type="OrthoDB" id="9946910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.340:FF:000007">
        <property type="entry name" value="Nucleophosmin 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004301">
        <property type="entry name" value="Nucleoplasmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024057">
        <property type="entry name" value="Nucleoplasmin_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747:SF28">
        <property type="entry name" value="NUCLEOPHOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747">
        <property type="entry name" value="NUCLEOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03066">
        <property type="entry name" value="Nucleoplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB67638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="295" mass="33399" checksum="7C1C85C9DD37AC94" modified="2019-05-08" version="1" fragment="single">CVLEEGKKEYKFQLHDDRMAHQLILRTVCVGPETKDELHVIELEAMNPNGKMIKVPLTSLKPSILTTTVLGGFEVSPPVCLRLKTGSGPIYISGEHIVGSKRRCRTRTFHLKSSVYKENRIQLRPWREMLPQILIVSGIILIGLDVMQTHHEEELAPVHPPYLAPLLEKRTPDTDSDSESESEDNHQAMSPVKKQLVVSASSPTALHPAKKKAKLEELAKDKAMNDKVKSEEDDDEDDDADDEDEDDDEDDEEEDEEDDDDDDDDDDDDEEEEEEEDDEEDEVTKTPVRTSVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3I0</accession>
    <name>A0A401P3I0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neogenin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0000759</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000154">
        <property type="protein sequence ID" value="GCB67673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3I0"/>
    <dbReference type="STRING" id="75743.A0A401P3I0"/>
    <dbReference type="OMA" id="HDPDEVG"/>
    <dbReference type="OrthoDB" id="114660at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010560">
        <property type="entry name" value="Neogenin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06583">
        <property type="entry name" value="Neogenin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Neogenin C-terminal" evidence="8">
        <location>
            <begin position="114"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB67673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="411" mass="44447" checksum="0169FB95620E186C" modified="2019-05-08" version="1" fragment="single">WPADTNLIDRSSLNEPPIGQMHPPHGSVTPQQNGNLLVIIVVSIGAVMVVVVIVVAVICTRRSSAQQRKYVHILLTNLIFGFHLALVTFEGGQLLLRKRAAHSGGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPSVRDSPMQQSCQDITPVSHSHSENQLTSKSGSHSGHDPDEVGSSMSTLERSLAARRGTRPKLMIPMDSQPSNPTVVSAIPVPTLESAQYPGILPSPTCGYPHPQFPLRTMPFPTLTVDRGFGSAMSEAQTSHLQQPAMLTQTQPEHSSGEEAPSRTIPTACVRPTHPLRSFANPLLPPPMTALEPKVPYTPLLSQPGSNLTLSHGKTASLGLAGKARSPLLPVSVPTAPEVTEESHRTEDQSNVYEQDDLSEQMASLEGLMKQLNAITGSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3Y5</accession>
    <name>A0A401P3Y5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000161">
        <property type="protein sequence ID" value="GCB67842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3Y5"/>
    <dbReference type="STRING" id="75743.A0A401P3Y5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="153" mass="17342" checksum="D51612DF3AAC1E60" modified="2019-05-08" version="1">MHINGLRSNLKNMEDVIPSTEEQIQTLKAVKANTTEQIEDLTNELRESREQSVIAEESFHSKLNAHVKLLNSSKDFADDSETKTTQLPGVLAELNKKMCKLGKKLEKRKEIKYLAKTVKLVGTKVPLLKHELQYVVTVSHTMKEEGGKKTLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4I8</accession>
    <name>A0A401P4I8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007178">
        <property type="protein sequence ID" value="GCB68055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4I8"/>
    <dbReference type="OrthoDB" id="10521605at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7548" checksum="4A32491431339BDC" modified="2019-05-08" version="1" fragment="single">EMSGEENLPNPSEEEIDEDEEETITAVAPAVVFQEEELADVTTSPAFQCLDEVSSLLYLYMVLWCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4K1</accession>
    <name>A0A401P4K1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 146</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0013773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007178">
        <property type="protein sequence ID" value="GCB68052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4K1"/>
    <dbReference type="STRING" id="75743.A0A401P4K1"/>
    <dbReference type="OMA" id="SERESCI"/>
    <dbReference type="OrthoDB" id="10262929at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF34">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="131"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="486"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB68052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="89982" checksum="97D089DC7091A423" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P510</accession>
    <name>A0A401P510_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0005271</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Centromere</location>
            <location evidence="4">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001624">
        <property type="protein sequence ID" value="GCB68231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P510"/>
    <dbReference type="OMA" id="KMRHNWL"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000001">
        <property type="entry name" value="CLIP-associating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000005">
        <property type="entry name" value="CLIP-associating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000006">
        <property type="entry name" value="CLIP-associating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000031">
        <property type="entry name" value="CLIP-associating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF28">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="19">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="17">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="19">
        <location>
            <begin position="311"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="19">
        <location>
            <begin position="822"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="19">
        <location>
            <begin position="1220"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="544"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="611"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1049"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1130"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1052"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1130"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB68231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1469" mass="162474" checksum="98E34A1041FE72FB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P655</accession>
    <name>A0A401P655_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCR4-NOT transcription complex subunit 1 HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008542">
        <property type="protein sequence ID" value="GCB68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P655"/>
    <dbReference type="STRING" id="75743.A0A401P655"/>
    <dbReference type="OMA" id="VQTIQEM"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38646" checksum="D561E06ED2B24B7B" modified="2019-05-08" version="1">MNLDSLSLALSQISYLVDNLTKKNYKSSQQEISHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECASLITKPNFISTLCYAIDNPLHYQKVNFSEYFLILPLDVSILEKELVNTLQFVKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILTDSGGIAKTMDSSLADFMQEVGYGFCTNAEECRQIILQFGVREVTASQVARVLGMMARTHSGLTDGISLQSISAPSSGIWSDGKDKSDSAQAHTWNVEIFIDVVKEVVSKQVEFEQKLQTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7S3</accession>
    <name>A0A401P7S3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cell division cycle protein 20 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">p55CDC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0008340</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation. Recognizes and binds the destruction box (D box) on protein substrates. Involved in the metaphase/anaphase transition of cell cycle. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with NEUROD2. Interacts with dimeric MAD2L1 in its closed conformation form. Interacts with BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with SIRT2. Interacts with isoform 1 of NEK2. Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex. Interacts (via the N-terminal substrate-binding domain) with FBXO5. Interacts with CCNF. Interacts with USP22.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003168">
        <property type="protein sequence ID" value="GCB69166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7S3"/>
    <dbReference type="STRING" id="75743.A0A401P7S3"/>
    <dbReference type="OrthoDB" id="8608526at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000224">
        <property type="entry name" value="cell division cycle protein 20 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015152">
        <property type="entry name" value="Growth/epo_recpt_lig-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF3">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09067">
        <property type="entry name" value="EpoR_lig-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 16" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="327"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="813"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="896"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="1031"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="603"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB69166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122447" checksum="7ECD72E266A18D5B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P871</accession>
    <name>A0A401P871_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003185">
        <property type="protein sequence ID" value="GCB69318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P871"/>
    <dbReference type="STRING" id="75743.A0A401P871"/>
    <dbReference type="OMA" id="QCPPSNS"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032444">
        <property type="term" value="C:activin responsive factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20022">
        <property type="entry name" value="FH_FOXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000278">
        <property type="entry name" value="Forkhead box protein H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052327">
        <property type="entry name" value="Activin_resp_transcr_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047511">
        <property type="entry name" value="FH_FOXH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47316">
        <property type="entry name" value="FORKHEAD BOX PROTEIN H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47316:SF1">
        <property type="entry name" value="FORKHEAD BOX PROTEIN H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="133"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="133"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="543" mass="60564" checksum="026EDA72D43DD103" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P872</accession>
    <name>A0A401P872_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005987">
        <property type="protein sequence ID" value="GCB69361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P872"/>
    <dbReference type="STRING" id="75743.A0A401P872"/>
    <dbReference type="OMA" id="AWIMERF"/>
    <dbReference type="OrthoDB" id="10029558at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB69361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="128" mass="14419" checksum="7E527BFC9C828397" modified="2019-05-08" version="1">MTSELESSLTSMDWLPQLTMRAAIQKADAAQNVAGGGVAKKTPLLDPNTTLDQDAQNKDGKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGSGWKVSYWEENYMARYCSESACNLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8J8</accession>
    <name>A0A401P8J8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caspase activity and apoptosis inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001708">
        <property type="protein sequence ID" value="GCB69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8J8"/>
    <dbReference type="STRING" id="75743.A0A401P8J8"/>
    <dbReference type="OMA" id="FEIHADE"/>
    <dbReference type="OrthoDB" id="10064012at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038991">
        <property type="entry name" value="CAAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740:SF3">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15335">
        <property type="entry name" value="CAAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32631" checksum="84193FC7E409DEA2" modified="2019-05-08" version="1">MAGKKSAKDKKRKRSHGEESHGERKWLNSDSGTNESGRIASEKEMTNEASDLEEGGLDLNVTLKPISSYISDRKEMLEQCFRVIGEKKLQKMLPDILKNCSVEEIKALCLEQLTLLSDKKLLQIIEGDYFGSSDTEEEVGENYRYKKKLDTQSQQDNNVDSTSSYKECNEQEAPELKQGGGSGDESDALSINAEAYDSDIEQNCNDQDDSTNLVPQKGTATRAGVEDEIQKDIEKSVNEILGLSGSTTESPQTAGSPNPDGDGLHPSAQQLELLELEMRARAIKALMRAGDTKMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9Q1</accession>
    <name>A0A401P9Q1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysozyme g</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003244">
        <property type="protein sequence ID" value="GCB69881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9Q1"/>
    <dbReference type="STRING" id="75743.A0A401P9Q1"/>
    <dbReference type="OMA" id="HINQGAT"/>
    <dbReference type="OrthoDB" id="10021790at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002152">
        <property type="entry name" value="Glyco_hydro_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31698:SF12">
        <property type="entry name" value="LYSOZYME G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31698">
        <property type="entry name" value="LYSOZYME G FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00749">
        <property type="entry name" value="LYSOZYMEG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12328" checksum="D972039D4C1DEAB2" modified="2019-05-08" version="1" fragment="single">MLPSCKRSRYTGIPFLSNLLTSSIYGDITKVETTGASDVTARQDKLSEIGVAASHKMMETDLGRLNKYKTTINKVAGANKIDPAIIGAIMSRESHGGNVLENGWGDHGNGFGLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAQ8</accession>
    <name>A0A401PAQ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0001221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000264">
        <property type="protein sequence ID" value="GCB70200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAQ8"/>
    <dbReference type="STRING" id="75743.A0A401PAQ8"/>
    <dbReference type="OrthoDB" id="8930705at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031697">
        <property type="term" value="F:beta-1 adrenergic receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070699">
        <property type="term" value="F:type II activin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000003">
        <property type="entry name" value="Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF27">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16663">
        <property type="entry name" value="MAGI_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB70200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="20301" checksum="57DF01846DBE0AB3" modified="2019-05-08" version="1">MHRWTISPVNQLPIVVTLLGTTRPPKEGEVPGVDYNFVTVEEFMELEKSGSLLESGTYEDNYYGTPKPPAEPTPVLLNVTDQILPGARPSSEGKRKRNKSVSNMEKAGIAPPEEEEEEEEEEERPIVNGNGTTITPGSHNTKTTSWLDPRLGRKAKLPEECKDDGDKLQSGNNGQKLENLKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB62</accession>
    <name>A0A401PB62_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0005657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001797">
        <property type="protein sequence ID" value="GCB70358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB62"/>
    <dbReference type="STRING" id="75743.A0A401PB62"/>
    <dbReference type="OrthoDB" id="9971371at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031365">
        <property type="entry name" value="CMIP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35087:SF1">
        <property type="entry name" value="RIKEN CDNA 4930505A04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35087">
        <property type="entry name" value="SIMILAR TO HYPOTHETICAL PROTEIN FLJ40298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15667">
        <property type="entry name" value="CMIP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="18165" checksum="53E6F8284C153A36" modified="2019-05-08" version="1" fragment="single">PVEWKKQRHGAFVCTQINPQSGKIAPRGEETFLLTGGSHSVEQLKEEKGNMGGNILASPKLCSMNLQQMLCSGTCLSKPDREEAAKAYTRIRAEGQNSLQSQTDEVHGGLSEQQQVALDAMSTTKQKSSSVGTAVSTPLHLKRVISQTNHSHVLVSDNTKHKLTAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBG6</accession>
    <name>A0A401PBG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004719">
        <property type="protein sequence ID" value="GCB70467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBG6"/>
    <dbReference type="STRING" id="75743.A0A401PBG6"/>
    <dbReference type="OMA" id="ISIACRY"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF51">
        <property type="entry name" value="COPINE-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="66" mass="7744" checksum="DB46EBE988FB710A" modified="2019-05-08" version="1">MQFCANKLDKKDFFGKSDPFMVFYRSNEDGTFTICHKTEVVKNTLNPVWLQFCIPVRALCNGDYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCB0</accession>
    <name>A0A401PCB0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0010843</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004768">
        <property type="protein sequence ID" value="GCB70748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCB0"/>
    <dbReference type="STRING" id="75743.A0A401PCB0"/>
    <dbReference type="OMA" id="DNWRMRY"/>
    <dbReference type="OrthoDB" id="5858677at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000018">
        <property type="entry name" value="Mannose receptor, C type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24562">
        <property type="entry name" value="CysR_MRC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-II" evidence="13">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="206"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="338"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="429"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="579"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB70748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="656" mass="74426" checksum="0ED719DB65787B8A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFC5</accession>
    <name>A0A401PFC5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Interleukin-1 receptor accessory protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0001719</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000398">
        <property type="protein sequence ID" value="GCB71850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFC5"/>
    <dbReference type="STRING" id="75743.A0A401PFC5"/>
    <dbReference type="OMA" id="RVILIEC"/>
    <dbReference type="OrthoDB" id="9925886at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000284">
        <property type="entry name" value="interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000009">
        <property type="entry name" value="X-linked interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF10">
        <property type="entry name" value="X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="161"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB71850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="51788" checksum="F8D0D6F560900AF4" modified="2019-05-08" version="1" fragment="single">PRLLLPLENQQSIVEVQLGRPASLICRAFFGYSSVNPIIYWMKGEKYMEELEDSQVKESDIRVLNEHLGEKEVELSLLFDWVKETDLGNYTCIVENRIGRTQTSILLQRKDLMYRVELAGGLGAILLLITFLVTIYKCYNIEMMLFYRSHFGSDETEDDNKEYDAYLSYTKIDPDSLTQENRDEEQFTLEILPEVLEKHYGYKLFIPDRDLMPSGTYIEDLTRSVDQSRRLIIVLTPDYVIRRGWSIFQLESRLHNMLVTGEIRVILIECPDVEGIMNYHEIEALKDTIKLLSVIKWCGPKCNKLNSKFWKKVQYEMPIKKKEPVARGQVLDAGEQGIFGELQTVSTVSMAANSSTLASTQAELPPNFHKAGHMQMRHYCRTYEYEIPPASVPITSISNQHTYCNIPMALINGQAPQIIITRDPSLRDCAMNNARLPMSSREIGITSDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFK0</accession>
    <name>A0A401PFK0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane and coiled-coil domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0008959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003543">
        <property type="protein sequence ID" value="GCB71874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFK0"/>
    <dbReference type="STRING" id="75743.A0A401PFK0"/>
    <dbReference type="OMA" id="AGLYSYC"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB71874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="68593" checksum="41FE2285656A3EBA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH75</accession>
    <name>A0A401PH75_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000480">
        <property type="protein sequence ID" value="GCB72493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH75"/>
    <dbReference type="STRING" id="75743.A0A401PH75"/>
    <dbReference type="OMA" id="AMETQRY"/>
    <dbReference type="OrthoDB" id="9900339at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028257">
        <property type="entry name" value="CEP126"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31191">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31191:SF4">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 126 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15352">
        <property type="entry name" value="K1377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="364" mass="40349" checksum="F9CE6090A92EECED" modified="2019-05-08" version="1">MPEDRHPSSKINAENAAVPSLWPQVDILNDRSVTITTFPSSHLVSPYETVTKATYSVNATKVLPQKDDIYNGTKQDPNYEGNRLCLDCTPTEEEITLLWHGVHSALAQKDSASGDSRNYPSSRNSERKIDLQPHRTNVAQLTIDGSSLLNGVRSVSSVGRLFSAPSGAFVTAARRKHPMDTYSNGTKHRALLEQRRMNIGSTTHKSGQITQNIEISPFPSAFDPAQTINAVQNTEEAVSESTEQFMLAENLVETSAIDSDILTAMEAMETQRYSFLQNKVQRLGLSALSFEEQKLLQSLDRLDQRLQYIQETVQKSTSNGLSQIPSSFIIANGVSGSRSRPEHAICGTQKHRSLVTDARIQRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHI5</accession>
    <name>A0A401PHI5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0006383</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the Crumbs protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002139">
        <property type="protein sequence ID" value="GCB72603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHI5"/>
    <dbReference type="STRING" id="75743.A0A401PHI5"/>
    <dbReference type="OMA" id="RDMFIML"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
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        <property type="entry name" value="Notch, isoform B"/>
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        <property type="entry name" value="Protein crumbs 1"/>
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        <property type="entry name" value="Slit guidance ligand 2"/>
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        <property type="entry name" value="Weary, isoform C"/>
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        <property type="entry name" value="Laminin"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="EGF-like_CS"/>
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        <property type="entry name" value="Laminin_G"/>
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        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
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        <property type="entry name" value="hEGF"/>
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        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EGFBLOOD"/>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
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        <property type="entry name" value="EGF_CA"/>
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    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="15 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019517848" evidence="20">
        <location>
            <begin position="30"/>
            <end position="1256"/>
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    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="151"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="189"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="227"/>
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    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="265"/>
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        </location>
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    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="304"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="342"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="400"/>
            <end position="442"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="444"/>
            <end position="484"/>
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    </feature>
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        <location>
            <begin position="486"/>
            <end position="675"/>
        </location>
    </feature>
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        <location>
            <begin position="677"/>
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        </location>
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        <location>
            <begin position="719"/>
            <end position="891"/>
        </location>
    </feature>
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        <location>
            <begin position="893"/>
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            <begin position="956"/>
            <end position="1143"/>
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        <location>
            <begin position="1145"/>
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    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1183"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1220"/>
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    </feature>
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        <location>
            <begin position="82"/>
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    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="101"/>
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    <feature type="disulfide bond" evidence="19">
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            <begin position="139"/>
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    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="177"/>
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    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="215"/>
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    <feature type="disulfide bond" evidence="19">
        <location>
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    <feature type="disulfide bond" evidence="19">
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    <feature type="disulfide bond" evidence="19">
        <location>
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    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="474"/>
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    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="703"/>
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    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="919"/>
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    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1171"/>
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    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1187"/>
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    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1208"/>
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    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1246"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB72603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1256" mass="138246" checksum="8B031B7D1CF361C6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHM7</accession>
    <name>A0A401PHM7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">N-acetyllactosaminide alpha-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0002075</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:138024"/>
            <dbReference type="EC" id="2.4.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="19">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.87" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01000498">
        <property type="protein sequence ID" value="GCB72594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHM7"/>
    <dbReference type="STRING" id="75743.A0A401PHM7"/>
    <dbReference type="OMA" id="WEEMFDS"/>
    <dbReference type="OrthoDB" id="10013941at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047276">
        <property type="term" value="F:N-acetyllactosaminide 3-alpha-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000022">
        <property type="entry name" value="Histo-blood group ABO system transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005076">
        <property type="entry name" value="Glyco_trans_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10462">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10462:SF26">
        <property type="entry name" value="N-ACETYLLACTOSAMINIDE ALPHA-1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03414">
        <property type="entry name" value="Glyco_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB72594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="336" mass="39276" checksum="A5403156714047BA" modified="2019-05-08" version="1">MQVTLDINKQMVFVVLLFMAVLSVVYLSYHPPRLTTQVVKKKLQFDWRKNDVHSGTQSWFNSSAVTDQQTLTSWGAPILWEGTFNPVERDEFYSKKKTVIGLTVFAIGRYLDRYLKDFLESAEQHFMKGHRVIYYVMVDIASKVPALQLSPGRNLTVIEVPRQSRWQDISMMRMQQIGDLIQDQIRFEVTYLFCFDVDQVFVGRFGVEALAYSVAQIHSAFFAANRNKFTYERSPKSAAYIALDEGDFYYHAAVFGGRPDLVLNLTRTCLEGIIRDKSNKVEAVWHDESHLNRYFLDHKPAKLLSPEYCWDLMPAKHIRYVRLKWLPKDYKKLRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIN2</accession>
    <name>A0A401PIN2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000556">
        <property type="protein sequence ID" value="GCB72959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIN2"/>
    <dbReference type="STRING" id="75743.A0A401PIN2"/>
    <dbReference type="OMA" id="EDMPMSP"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000147">
        <property type="entry name" value="GS homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042191">
        <property type="entry name" value="GSH1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47421:SF2">
        <property type="entry name" value="GS HOMEOBOX 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47421">
        <property type="entry name" value="GS HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB72959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="247" mass="27278" checksum="D681A4B09ED8B85A" modified="2019-05-08" version="1">MPRSFLVDSLIVRDTNEKASPGVFESNTPLLPYAMHPPHSLALSAGSCHSRKSGLLCVCPLCVTASQLHPGPPGIPFLKAQFPTFSPQYCHSALSRHHRASGVTVDHGPSIYSASYSMADPRQFHCLSLASETSSSQLQSSKRMRTAFTSTQLLELEREFASNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKSGSAQRTPASCKCSSLTSANCTEREEEMPMSPSSSGKDDRDLSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIP9</accession>
    <name>A0A401PIP9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="12">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0002291</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="12"/>
    <dbReference type="EMBL" id="BFAA01000562">
        <property type="protein sequence ID" value="GCB72994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007398">
        <property type="term" value="P:ectoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.150:FF:000024">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.20.70.10:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.2410.10:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF1"/>
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    <dbReference type="FunFam" id="3.90.1750.10:FF:000007">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF2"/>
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    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
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    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
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        <property type="entry name" value="HECT_dom"/>
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    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
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        <property type="entry name" value="WW_dom"/>
    </dbReference>
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        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF293">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00632">
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        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
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    </dbReference>
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        <property type="entry name" value="C2"/>
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    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WW_DOMAIN_1"/>
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        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
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    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="236"/>
            <end position="269"/>
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    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="282"/>
            <end position="315"/>
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    <feature type="domain" description="HECT" evidence="17">
        <location>
            <begin position="398"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13 14">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
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    <evidence type="ECO:0000259" key="15">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB72994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="735" mass="84025" checksum="424578AB546AE60F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ46</accession>
    <name>A0A401PJ46_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Diacylglycerol kinase</fullName>
            <shortName evidence="23">DAG kinase</shortName>
            <ecNumber evidence="23">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0002360</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40323"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="22">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 23">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="23"/>
    <dbReference type="EMBL" id="BFAA01000592">
        <property type="protein sequence ID" value="GCB73121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJ46"/>
    <dbReference type="STRING" id="75743.A0A401PJ46"/>
    <dbReference type="OMA" id="PAWIIRI"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056383">
        <property type="entry name" value="DGKI-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF43">
        <property type="entry name" value="DIACYLGLYCEROL KINASE ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23578">
        <property type="entry name" value="DGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 23" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="25">
        <location>
            <begin position="147"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="688"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB73121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="737" mass="82469" checksum="3B48D6D89EEA6D39" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKA5</accession>
    <name>A0A401PKA5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000676">
        <property type="protein sequence ID" value="GCB73567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKA5"/>
    <dbReference type="OrthoDB" id="5914732at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="21571" checksum="D9BC14524C432A96" modified="2019-05-08" version="1">MVPHVPPEKDWARSCQPRWKRDPGDGLPREDKQTVVRGLVRGCAEERPNGVERIGEDLLPAGNWETLKLMGKNDGLPHRRVLPLHLPVSLRVVARSPARGDALTEQVLTQLIAHERGALVTVDICRETEQGEDAVQCLYNGAEVMSGHRIAKGKREYSSMTVWKYILRLVEGRGPLKAMLRRSKGRRPLPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKR1</accession>
    <name>A0A401PKR1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Unkempt zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000719">
        <property type="protein sequence ID" value="GCB73710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKR1"/>
    <dbReference type="STRING" id="75743.A0A401PKR1"/>
    <dbReference type="OMA" id="CIDLPCH"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040594">
        <property type="entry name" value="UNK_Znf_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18384">
        <property type="entry name" value="zf_CCCH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Unkempt zinc finger" evidence="2">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="99" mass="11526" checksum="65D50535AEA635AE" modified="2019-05-08" version="1">MPSVSKAAATSASPQTEKPSHYTYLKEFRTEQCPLFLQHKCAQHRPFTCFHWHFLNQRRRRPIRRRDGTFNYSPDVYCTKYDETTGICPDGDEKGVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKS8</accession>
    <name>A0A401PKS8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000721">
        <property type="protein sequence ID" value="GCB73732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKS8"/>
    <dbReference type="OrthoDB" id="10378755at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="342" mass="37990" checksum="FEFD411CA5FC5E2F" modified="2019-05-08" version="1">MPLTLAGEKHFTCKVKLTHNTQERSLTGGWVPYIKEQTGQEEFTRKVFILSNPITIGGSDMGMSEDTRVSMGTSDGDGGELTAVTEIPERAGEEGTEVNTSQQCGMAAAVEEGEECQEDKMSNWEGSVGEFKLSIVACVKEEVCDDPAAVMEGEHLEPSGGEKPTSSGSEALPSPQAHGRRQAHAAGEENRDDLKPLEHLHQEQVQSTDSSQATSNMPQQTLTEFKTDVSQNLQRTNEILQYHLQRNNEFLQQQNEVLRQQNEIQNQHLRRNNEILQQQNEVLYQFLQRSNETLNEMRQILSQIVAPASPGQQQPSAESTAAGHASGTGEVMSQRWGRHRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PL75</accession>
    <name>A0A401PL75_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0002959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000771">
        <property type="protein sequence ID" value="GCB73877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PL75"/>
    <dbReference type="STRING" id="75743.A0A401PL75"/>
    <dbReference type="OMA" id="TESTGKX"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015193">
        <property type="term" value="F:L-proline transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005298">
        <property type="term" value="F:proline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015816">
        <property type="term" value="P:glycine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904271">
        <property type="term" value="P:L-proline import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002438">
        <property type="entry name" value="Neutral_aa_SLC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF44">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01206">
        <property type="entry name" value="ORPHTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB73877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="63041" checksum="639C37A86E6B77E7" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMI0</accession>
    <name>A0A401PMI0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Collagen alpha-1(VII) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0003444</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000934">
        <property type="protein sequence ID" value="GCB74354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PMI0"/>
    <dbReference type="OMA" id="QTFFAVD"/>
    <dbReference type="OrthoDB" id="9940467at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd22627">
        <property type="entry name" value="Kunitz_collagen_alpha1_VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000307">
        <property type="entry name" value="collagen alpha-1(VII) chain isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001333">
        <property type="entry name" value="collagen alpha-1(VII) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000001">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019215946" description="Collagen alpha-1(VII) chain" evidence="9">
        <location>
            <begin position="37"/>
            <end position="2866"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="50"/>
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    <sequence length="2866" mass="299402" checksum="C02681C6202198DE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <dbReference type="NCBI Taxonomy" id="75743"/>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPR5</accession>
    <name>A0A401PPR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hyaluronidase</fullName>
            <ecNumber evidence="9">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0020885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="9"/>
    <dbReference type="EMBL" id="BFAA01017553">
        <property type="protein sequence ID" value="GCB75124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPR5"/>
    <dbReference type="STRING" id="75743.A0A401PPR5"/>
    <dbReference type="OMA" id="QYYIREA"/>
    <dbReference type="OrthoDB" id="5796153at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000065">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF38">
        <property type="entry name" value="HYALURONIDASE-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="71"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="393"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB75124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="467" mass="52705" checksum="20276497A9C7318A" modified="2019-05-08" version="1" fragment="single">AVINLTGRSSPAAAKRAIAMLSGLTLLAGTLFYLSTHPAIIRGVEFKPASASPMIHNKPFIVIWNTPTAGCKTKFNVDLDLSAFDIVENENESFVGENITIFYKNKLGLYPFYTDEGTPVNGGLVQKASLSNHLTVATKDIADLLGQDFHGLAVIDWEAWRPLWDRNWGSLDIYRKESEELVRSKYPYLPESEILRIAKKEYETAAQNFMRQTLELGRTLRPKGYWGFYKFPDCYNYFREDAPNNYTGHCNKEDIPRNDQLAWLWKASRCLYPSIYIPEKLKSSNNVQKFVHYKIKEALRVAALDPTSDALPVLVYSIYSYIKTLDFLSEIDLVHTIGESAAMGASGVVLWGDLNFSRTMERCEALKLYIDKELGRYVLNTTTAAMLCSRAICSGHGRCVRKDPESRTYLQLDPKSFEILSVLSSAGSVLTAHGEIHSEDVQSMREQFACQCYKGWMGPHCQEKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ30</accession>
    <name>A0A401PQ30_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylglycine monooxygenase</fullName>
            <ecNumber evidence="2">1.14.17.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0018190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O</text>
            <dbReference type="Rhea" id="RHEA:21452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13486"/>
            <dbReference type="Rhea" id="RHEA-COMP:15321"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="ChEBI" id="CHEBI:137000"/>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
            <dbReference type="EC" id="1.14.17.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="12">Binds 2 Cu(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.3" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01012428">
        <property type="protein sequence ID" value="GCB75230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ30"/>
    <dbReference type="STRING" id="75743.A0A401PQ30"/>
    <dbReference type="OMA" id="CMCHEST"/>
    <dbReference type="OrthoDB" id="10018185at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004504">
        <property type="term" value="F:peptidylglycine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020611">
        <property type="entry name" value="Cu2_ascorb_mOase_CS-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00084">
        <property type="entry name" value="CU2_MONOOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019254620" description="peptidylglycine monooxygenase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="14">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB75230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="120" mass="13734" checksum="D69E952ACF1E8362" modified="2019-05-08" version="1">MAGFINKLLLVFLILQNNCMCHESTLSLLKRYRQSPWALPSDCPKNRHPDISPNSLNFKLEVRMPGITPVMSDSYFCTFVPVPPGQKSYIVDFKPHASMDTVHHMLLFGCNMPATSEEYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ96</accession>
    <name>A0A401PQ96_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Glucosylceramidase</fullName>
            <ecNumber evidence="23">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0018201</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70255"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:72956"/>
            <dbReference type="ChEBI" id="CHEBI:73432"/>
            <dbReference type="ChEBI" id="CHEBI:189066"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70256"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:70257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:14297"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:14298"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70235"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189066"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70236"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:70237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:58264"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:58265"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:58266"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70239"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:70240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>beta-D-glucosyl-(1&lt;-&gt;1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside</text>
            <dbReference type="Rhea" id="RHEA:70315"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:74450"/>
            <dbReference type="ChEBI" id="CHEBI:76302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:70316"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:70317"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70311"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:70312"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:70313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside</text>
            <dbReference type="Rhea" id="RHEA:58324"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:139140"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:58325"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:58326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside</text>
            <dbReference type="Rhea" id="RHEA:70307"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:72956"/>
            <dbReference type="ChEBI" id="CHEBI:76297"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:70308"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:70309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside</text>
            <dbReference type="Rhea" id="RHEA:70303"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:45815"/>
            <dbReference type="ChEBI" id="CHEBI:65222"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:70304"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:70305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-xylosyl-(1&lt;-&gt;1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70251"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70252"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:11956"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11957"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Steroid metabolism; cholesterol metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 23">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="23"/>
    <dbReference type="EMBL" id="BFAA01012448">
        <property type="protein sequence ID" value="GCB75306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ96"/>
    <dbReference type="STRING" id="75743.A0A401PQ96"/>
    <dbReference type="OMA" id="FGGIAWH"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="UniPathway" id="UPA00296"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9 23" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="24">
        <location>
            <begin position="201"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="25">
        <location>
            <begin position="553"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB75306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="620" mass="70186" checksum="B3680DB1F5EFE7F7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRN0</accession>
    <name>A0A401PRN0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Isobutyryl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="8">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Acyl-CoA dehydrogenase family member 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0018259</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>propanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = acryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:31287"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57367"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31288"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01012543">
        <property type="protein sequence ID" value="GCB75770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRN0"/>
    <dbReference type="STRING" id="75743.A0A401PRN0"/>
    <dbReference type="OMA" id="FHATENC"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052547">
        <property type="entry name" value="Mito_Isobutyryl-CoADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831:SF1">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="16">
        <location>
            <begin position="100"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB75770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="252" mass="26972" checksum="E2E06366FE0AE11F" modified="2019-05-08" version="1" fragment="single">GSGSDAASLITTAKRDGDCYILNGSKAFISGGGETDLYVLMCRTGNTGPKGISCLLVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVSNLIGKEGDGFSIAMNGLNGGRINIASCSVGAAYASILLTQDHLKVRKQFGKPLANSQYLQFKLAEMATGLVAARLMVRNAAAALQEGRQDAVTLCAMAKLFATDECFTICNQALQMHGGYGYLKDYAVQQFVRDTRVHQILEGTNEVMRMLISKNLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSB1</accession>
    <name>A0A401PSB1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0015408</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008733">
        <property type="protein sequence ID" value="GCB76010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSB1"/>
    <dbReference type="STRING" id="75743.A0A401PSB1"/>
    <dbReference type="OMA" id="INWQVNS"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06364">
        <property type="entry name" value="PBP1_CaSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000067">
        <property type="entry name" value="Olfactory receptor C family, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF1">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00592">
        <property type="entry name" value="CASENSINGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019159563" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="14">
        <location>
            <begin position="22"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="15">
        <location>
            <begin position="618"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB76010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="914" mass="101401" checksum="7E7DC9A90C3E47AE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSG6</accession>
    <name>A0A401PSG6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0020978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017783">
        <property type="protein sequence ID" value="GCB76086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSG6"/>
    <dbReference type="STRING" id="75743.A0A401PSG6"/>
    <dbReference type="OMA" id="AKPPYWI"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019156103" evidence="5">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="124"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB76086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="339" mass="39202" checksum="9E9BA22B33F085EB" modified="2019-05-08" version="1">MVFFLSVMCILTGVSMASTIPFIDKEWELWKLMYGKSYPNLEEDQARRGIWLDNLEKIDAHNAQYLQGNTMYEMTMNQFGDLTPMEFANLYTDARISEMVNYTDDALFGFEMEELEEMEEINDLPQEVDWRKMHYVGKIKDQGMCLSCYAFTAVGALEGQLAKKKKQLIELSVQNIIDCSDEYRNFGCRGGLPYHAFQYIRDHGIESEQSYPYQAKKNDKCSFNNSKSVIKIKGFRRIKNYSEKQLAAVIRRVGPLSVLICSAHDSWRFYKSGILDNADCNNKKIDHAVLLIGYVDEHPTGYWIIKNSWGTSWGERGYIRLVKGKNMCKITHCASYPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSL5</accession>
    <name>A0A401PSL5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015202">
        <property type="protein sequence ID" value="GCB76098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSL5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="7833" checksum="59B72F7F67E06252" modified="2019-05-08" version="1" fragment="single">VPECEFGSAESEEKSRLDTDPLSTTLRRADRTEAGGDRRLIHNLTPSKANIRSPERERERERERPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTM0</accession>
    <name>A0A401PTM0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0016563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010083">
        <property type="protein sequence ID" value="GCB76471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTM0"/>
    <dbReference type="STRING" id="75743.A0A401PTM0"/>
    <dbReference type="OMA" id="ASNCIIY"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="12293" checksum="AB709C86B896A193" modified="2019-05-08" version="1">MPITNASLMNILSPLFGTIKASAQFNYCIDIPWLVKQYPEEFRTKPLLVVHGEQRQSKAELHEDAHPYTNIRLCQDEVKESTASNCIIYDYVRKSSASYSLVRILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUC2</accession>
    <name>A0A401PUC2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008861">
        <property type="protein sequence ID" value="GCB76734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PUC2"/>
    <dbReference type="OMA" id="GNKLCFP"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="445" mass="45546" checksum="DDF941F7006F8E6F" modified="2019-05-08" version="1">MDLLRILHGPPEPGAYSSKALQNSGCKILPGDKLGLPGNKLGLPGNKLGLPGNKLGLPGNKLGLPGNKLGLPGNKLGLPGNKLDLPGNKLGLPGDKLGLPGNKLGLPGNKLGLPGNKLGLPGNKLGLPGNKLCFPGNKLDLPDNKLGLPGNKLEQAGFAGNKLDLPGNKLDLPGNKVGLPGNKLGLPGNKLGFPGNKLGLTGNKLCITGNKLCLPGNKLCLPGNKLGFPGNTLVLPSNKLSLPGNKLCFPGNKLGLPGNKLGLPGNKLCSPGNKLGLPGNKLGLRLPGNKLGLPGNKLGLPGNKLGLRLPGNKLGLPGNKLGLRLPGNKLDLPGNKLGLRLPGNKLRLPGNKLGLRLPGNKLDLPGNKLGLRLTGNKLGFPGNKLGLRLPGTKLGLCLPGNKLDLPGNKLGLRLPGNKLGLPGNTLGLRLPGLFIEASREEMDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV24</accession>
    <name>A0A401PV24_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014078">
        <property type="protein sequence ID" value="GCB76986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV24"/>
    <dbReference type="STRING" id="75743.A0A401PV24"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
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        <location>
            <begin position="821"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="866"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="903"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="917"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1145" mass="125640" checksum="39B845296647E363" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWJ5</accession>
    <name>A0A401PWJ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0021107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018126">
        <property type="protein sequence ID" value="GCB77501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PWJ5"/>
    <dbReference type="OMA" id="CMIWISN"/>
    <dbReference type="OrthoDB" id="6103117at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IG"/>
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    </dbReference>
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        <property type="entry name" value="IGv"/>
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    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019395019" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB77501.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401PWK8_SCYTO</name>
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        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
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        <name evidence="11" type="ORF">scyTo_0015676</name>
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        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
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                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01008996">
        <property type="protein sequence ID" value="GCB77517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWK8"/>
    <dbReference type="STRING" id="75743.A0A401PWK8"/>
    <dbReference type="OMA" id="ESIWQDM"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000036">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000063">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF166">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="48"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB77517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="470" mass="54200" checksum="F55354ABF04A7396" modified="2019-05-08" version="1" fragment="single">MSFTSPHRPVTRHQSSIYRLAEDFFWIGGSIVTPATWRLGQFVERCMSLMQSGTQMVKLRGGSKGLVRFYYLDEHKTCIRWRPSRKNEKAKISIDAIREVCEGKQSEIFQRYPDGSFDPNCCFSIYYGDHMESLDLVSSNGEEARTWITGLKYLMAGISDEDSLSKRQRTRDQWLKQTFAEADKNGDGCLSVGEVLQLMHKLNVNLPRQKVKQMFKEADTDENQGTLDFEEFCAFYKMMSTRRDLYLLMLMYSNHKDQLDSDDLKRFLEVEQKMTGVMKEHCLEIVDKFEPCLENQKQGVLGIDGFTNYMRSPAGDIFNPEHYKVNQDMTQPMCDYYIASSHNTYLMGDQLMSQSRVDMYAWVLQSGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFRDVIETINKYAFAKSEYPVILSVENHCSVPQQKKMAQCLCEILGDKLDVSSEHEEDMTQLPSPDSLKGKILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWN8</accession>
    <name>A0A401PWN8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM5</name>
        <name evidence="15" type="ORF">scyTo_0020005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015532">
        <property type="protein sequence ID" value="GCB77539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWN8"/>
    <dbReference type="STRING" id="75743.A0A401PWN8"/>
    <dbReference type="OMA" id="NNICTLI"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB77539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="11534" checksum="26619D6369525693" modified="2019-05-08" version="1">MTTRQVVLLNVKMALISTNPSQLLPLELVDKCIGSRIHIVMKNDKEIVGTLLGFDDFVTLDMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLIPGGEGPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWW8</accession>
    <name>A0A401PWW8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0016720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associated with the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010294">
        <property type="protein sequence ID" value="GCB77625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWW8"/>
    <dbReference type="STRING" id="75743.A0A401PWW8"/>
    <dbReference type="OMA" id="GVGDIWG"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="12">
        <location>
            <begin position="12"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB77625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="378" mass="44198" checksum="34B866A48341506C" modified="2019-05-08" version="1" fragment="single">PDRNSSRRQWGEEDHNSAEKDNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYSNTGRNPDEVGYAGDNFVRYTGDTVRMAQTQLFAWEAYEKGSEVHLQADPTKLEVLHQSFKVKKEEFEKQQKGSILEKYGGQEHLNAPPRELLLAQTEDYVEYSRHGAVLKGQEKAVMRSKYEEDVLIGNHTSVWGSYWKEWRWGYKCCHSFIKTSYCTGEAGKQIAVEDKSDCLSEIPDSNQEVYESIPKTLVEIHKEKLKEGKKKKKKQRKSHSSDSEDEDAKKEKLKKALVAEEARLKQVEQILQIDERKRGYNSIFEIKEPTEEEIEAYRMKRQRPEDPMASFLGQQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZQ3</accession>
    <name>A0A401PZQ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0020127</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01015793">
        <property type="protein sequence ID" value="GCB78601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZQ3"/>
    <dbReference type="STRING" id="75743.A0A401PZQ3"/>
    <dbReference type="OMA" id="IRYCHDC"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000658">
        <property type="entry name" value="Protein CBG12184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB78601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="270" mass="30659" checksum="67DC3FF3F9DCC57D" modified="2019-05-08" version="1">MEKLLLSKGYQLGNTIGEGTYSKVKEAYCRKQQRKVAIKIINRQTAPKDFIHKFLPRELQIVQNLDHKNIIKVHEIWESDDGKICIIMELAEGGDVLEHIKREGPLPEELAKTLFRQLVAAIRYCHDCGIAHRDLKCENTLLDKSFNVKLADFGFAKNFRTGTAELSKTFCGSTAYAAPEVLQGVPHESIKSDIWSMGIVLYTTLCGHLPFDDSNIPKMLWLQQNGVAFPQQLELSRQCRDLVGRLLEPDCSLRPPIQEVSFHPWLADSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZZ7</accession>
    <name>A0A401PZZ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0021227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018423">
        <property type="protein sequence ID" value="GCB78688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZZ7"/>
    <dbReference type="STRING" id="75743.A0A401PZZ7"/>
    <dbReference type="OMA" id="WNNDRVN"/>
    <dbReference type="OrthoDB" id="8804268at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000022">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF424">
        <property type="entry name" value="CADHERIN-16 ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="169"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="245"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB78688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="339" mass="37850" checksum="E0C7D8FB9FAFB791" modified="2019-05-08" version="1" fragment="single">VNVTDAEGRQLDEPISITIVVTDRNDNGPLFEQELFLASVHQGATPGYRILSTPAIDLDDPSLPSGDLHYKIIRQVPTQPSDKMFAIRPRNGDIFLTSEGAELLDPGLVNEYTLTVQVKDMGDLNQGYYTHVDVIITITKNLWVRPDIVSVLENHEGPYPLAISKVQWNNDRVNYRMEAKAPYPEGPFTVDGEGAIYLTKPLDREQGEEYMLLISALGYDGTLYDEPLELGVTVIDQNDNTPVCFPESYQATVQERAVRGTRVVTLTASDQDDPRTGNADLHFRLYSQEPWSPQERLFTVDGEGTLRLAKDMTSYSSMKYQVKIEVADLAGLEGEVNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0Z3</accession>
    <name>A0A401Q0Z3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0015925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009281">
        <property type="protein sequence ID" value="GCB79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0Z3"/>
    <dbReference type="STRING" id="75743.A0A401Q0Z3"/>
    <dbReference type="OMA" id="GTYKQFR"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041481">
        <property type="entry name" value="CSN7_helixI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18392">
        <property type="entry name" value="CSN7a_helixI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="66"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="327" mass="36733" checksum="13FAF037772CAEAD" modified="2019-05-08" version="1">MKRRSQSIYLQLLTDKHAPEHYRVFGSVSQFDEFGRARSGAPSSPLKEGLRQRAWAQGTTFCAMAGESKSTSNPLEQFILLSRNAKGPALTTLISQVLEAPGVFVFGELLETPNIQELANGSHASYLQLLNLFAYGTYPDYLAIKGSLPELTLAQKNKLKHLTIVSLAARMKCIPYSMLLKDLDIKNLRELEDLIIEAIYTDIIQGKLDQRNQLLEVDFCIGRDLQKQDISNIVKTLQEWCDCCQAVLLGIEQQVLRVNQYKEGHTKTQQQVETEVANIKKTLKATASTSTQDPDQHPMDRDTPQLVEQRPSTKKLSKSKSLSSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1A3</accession>
    <name>A0A401Q1A3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VLIG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013284">
        <property type="protein sequence ID" value="GCB79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1A3"/>
    <dbReference type="STRING" id="75743.A0A401Q1A3"/>
    <dbReference type="OMA" id="VEYCETE"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052986">
        <property type="entry name" value="VLIG_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14819">
        <property type="entry name" value="GTP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14819:SF9">
        <property type="entry name" value="UP-REGULATOR OF CELL PROLIFERATION-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39589" checksum="449E41FD2E5EA9FB" modified="2019-05-08" version="1">MPAVRDAVLKSLSLKIVDDMKKTDPKGKYKLRNNFIVELLVHLKQKNSFEEYYRFLTDFESFSKDWLHDRVIAHCKEQSGGKIKFTHLAKEILTEITDEAKKVVRDAVTQNISGNAKSFLDLFVEKLKTRITMSKDEMKIGLSLADSNAKKFAETVLPSIAEIEKLLLHEITGWNVETKIKDLSVKPNEELFKGLFCCTKKCPFCGAFCESETIEHAQHFSKQHRPEGLNSYRWIQTQHLAMEICTALVAGNATFQNRDTNQKWISYKDYQTVNDYYKSWIIQRDPSAEATSYWKKVFHTFNKEFADRYGAKPAEIGNAWDIGWDKVKEDLNKTYNTNIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1N9</accession>
    <name>A0A401Q1N9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009339">
        <property type="protein sequence ID" value="GCB79305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1N9"/>
    <dbReference type="STRING" id="75743.A0A401Q1N9"/>
    <dbReference type="OMA" id="MHIVISK"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF5">
        <property type="entry name" value="COLLAGEN TYPE XIII ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB79305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="760" mass="79877" checksum="5760C4104FDE28D3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6R5</accession>
    <name>A0A401Q6R5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">GTP-binding nuclear protein Ran</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0022114</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021277">
        <property type="protein sequence ID" value="GCB81075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6R5"/>
    <dbReference type="STRING" id="75743.A0A401Q6R5"/>
    <dbReference type="OMA" id="FFWLARK"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB81075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="226" mass="25565" checksum="8E2C7FB962C48827" modified="2019-05-08" version="1" fragment="single">ASGRFLKIKTMGDQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLMFHTNRGAIRFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVQMDPALAAQYEEDLKVAQGTALPDEDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q869</accession>
    <name>A0A401Q869_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018973">
        <property type="protein sequence ID" value="GCB81572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q869"/>
    <dbReference type="STRING" id="75743.A0A401Q869"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7643" checksum="25A590D8314CE53D" modified="2019-05-08" version="1" fragment="single">VELHPYLTQSELVDFCASRDIALTAFSPLGSPGRSLLNDSADPKDLLKDPVVKLIAEKHRKSPAQVRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9D7</accession>
    <name>A0A401Q9D7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0022598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01023161">
        <property type="protein sequence ID" value="GCB81992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9D7"/>
    <dbReference type="STRING" id="75743.A0A401Q9D7"/>
    <dbReference type="OMA" id="RRELAYY"/>
    <dbReference type="OrthoDB" id="25346at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045839">
        <property type="term" value="P:negative regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037994">
        <property type="entry name" value="NDPk6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB81992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="132" mass="15718" checksum="BEDD8712817C2726" modified="2019-05-08" version="1">MVRFYKGRFFYQRVVEFMTSGPLRAYILAQDDAILRWRQLMGPTRVFRARYSAPESIRGNYGLTDTRNTTHGSDSPESAAKEISFFFPEFKEQQWFSTQEMSYRQGQYFYHSEKQVHLLRTQPEQLLQSQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9L4</accession>
    <name>A0A401Q9L4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0023053</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025824">
        <property type="protein sequence ID" value="GCB82060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9L4"/>
    <dbReference type="STRING" id="75743.A0A401Q9L4"/>
    <dbReference type="OMA" id="YANCELD"/>
    <dbReference type="OrthoDB" id="2984333at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF9">
        <property type="entry name" value="VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="19208" checksum="3536C1B78BCCE4CE" modified="2019-05-08" version="1" fragment="single">VYGEPGQLTIQDRMWINSDFNFDNVLSAMMALFTVSTFEGWPQLLYKAIDSHTEDMGPIYNYRVGISIFFIIYIILIAFFMMNIFVGFVIVTFQEQGEAEYKNCELDKNQRQCVQYALKARPLMRYIPKNTHQYKVWYVVTSSYFEYLMFALILLNTICLGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAF9</accession>
    <name>A0A401QAF9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024725">
        <property type="protein sequence ID" value="GCB82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAF9"/>
    <dbReference type="OrthoDB" id="10652423at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="19195" checksum="2EFFFE7557D89503" modified="2019-05-08" version="1">MKMRSWNGIERGKYKLTDLDWVDHRHDFNHIVIGYDVALEPPLNLSVKFHEADVGDVAREQEDTLPPLDHIVQEEYDQQDQVQNVEGDIPEQGPPGQVQHFPGEDGAHSDHKQDVEHSRSHNGANAHVTVGNEDSDERGEEFRGRPPCRHERGPRHIVRNVKSLDDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB78</accession>
    <name>A0A401QB78_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023601">
        <property type="protein sequence ID" value="GCB82612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB78"/>
    <dbReference type="STRING" id="75743.A0A401QB78"/>
    <dbReference type="OrthoDB" id="9950647at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="115" mass="12382" checksum="50177916CB585215" modified="2019-05-08" version="1">MTRVGSCSYLLCYFSIPLLSPMPKEGDVSKRLHVNEVGEGVGHPNGKASTWILQDYIDLDVCSKVTKLAVTPCNADDCNQNLIDTTGIPDSHIIALEENGGVTSFTKPIEETSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB99</accession>
    <name>A0A401QB99_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022353">
        <property type="protein sequence ID" value="GCB82664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB99"/>
    <dbReference type="OMA" id="GQPEEHH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="17433" checksum="0E422CEF9358A242" modified="2019-05-08" version="1">MEHPEEHAEENPEERPEENPEENPEDPMEHPEEHPEEHPEESPEENPEDPMGQPEEHHEERPEESPEDPMEHPEEHPEEHPEGHPEGHPEEHPEGHPEGHPEEQPEEKPEEQMEYPEEFPEEFPEEQPEEHPEENSEENPEEHRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBB9</accession>
    <name>A0A401QBB9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021008">
        <property type="protein sequence ID" value="GCB82660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBB9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="8077" checksum="9A22B2EB57D755BD" modified="2019-05-08" version="1" fragment="single">MVYWKFTHLPVMGIIYEEGCCHSPRNCLRHWTVELELPVHHSLTIHNDKINSHLIYFILFSCIQIGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBF6</accession>
    <name>A0A401QBF6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019705">
        <property type="protein sequence ID" value="GCB82682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBF6"/>
    <dbReference type="STRING" id="75743.A0A401QBF6"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF3">
        <property type="entry name" value="COPINE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8274" checksum="BDB96FB7F8D65F3D" modified="2019-05-08" version="1" fragment="single">VIKNTLDPVWKPFSTPLVSLCNGDVEKTVKILCYDYDNDGGHDFIGESQTTVAKMSEANSSTEVRIFPIVSLAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCE4</accession>
    <name>A0A401QCE4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01028958">
        <property type="protein sequence ID" value="GCB83043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCE4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="40" mass="4679" checksum="CC0C2D48F14BE762" modified="2019-05-08" version="1" fragment="single">VRWKAKEVLLRDGKREVEKRKGAKRQQSATKGAQVTEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCX7</accession>
    <name>A0A401QCX7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029314">
        <property type="protein sequence ID" value="GCB83224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCX7"/>
    <dbReference type="STRING" id="75743.A0A401QCX7"/>
    <dbReference type="OMA" id="FPHKLRP"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="368" mass="41612" checksum="DCEE103BC88CDFB0" modified="2019-05-08" version="1" fragment="single">KRKPAESQQPDKLFPQKLRPVGTQQPGKLFPQKLRPAGTQQPGKLFPEKLRPAESQQPGKLFPHKLRPVGTQQPGKLFPEKLRPVGTQQPGKLFPEKLRPAGTQQPGKLFPQKLRPVGTQQPGKLFPQKLRQAGSQQPGQLFPHKLRPAESQQPGKLLPQKLRPEEFQQPGKLFPQKLRPAECQKPDKLFPQKLRPAESQQPDKLFPEKRKPAESQQPDKLFPQKLRPAEFQQPGKLLPQKLRPAGSQQPDKLFPQKLRPAGFQQPGKLFPHKLRPAESQQPGKLFPQKLRPAESQQLGKLFPQKLRPAESQQAGKQRLGQRHNPQQSGVILIFTQILTGLLYISDCFLFCGQAGQRTQYLRKCIPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE48</accession>
    <name>A0A401QE48_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Distal membrane arm assembly complex 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01044162">
        <property type="protein sequence ID" value="GCB83633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE48"/>
    <dbReference type="STRING" id="75743.A0A401QE48"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15753" checksum="F336FAB6DB4B6163" modified="2019-05-08" version="1" fragment="single">GLNLTHLKLPDRHTVSDSGLQFLSQLEKLVELDLTDYTQVTDQGISHLSRLQRLMKLSLSNTLMTDAGLVHLQPLTDLEELCLDRTNVSSKGVAQCIRNLPRLQVLSLASTRVGDSVVTQGLLHCKQLVKLNLSRTRITDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEI3</accession>
    <name>A0A401QEI3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0024414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01045915">
        <property type="protein sequence ID" value="GCB83780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEI3"/>
    <dbReference type="STRING" id="75743.A0A401QEI3"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000005">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF184">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB83780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="15303" checksum="B63507F96B294667" modified="2019-05-08" version="1" fragment="single">LTYQVCHSCFKKQARLQRCGQCKFAHYCDRTCQKAAWTEHKNECVAIRNYGKPTNETIRLASRILWRMAREEDSVAEDRLSSLKDLQDHVDDLSEEENTQLASDVEVLRSYWHPNNQHFDNQFLSHIFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEK3</accession>
    <name>A0A401QEK3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01044665">
        <property type="protein sequence ID" value="GCB83801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEK3"/>
    <dbReference type="STRING" id="75743.A0A401QEK3"/>
    <dbReference type="OMA" id="RGHYRKG"/>
    <dbReference type="OrthoDB" id="5918936at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="177" mass="19373" checksum="9C4CE52AC8787C58" modified="2019-05-08" version="1" fragment="single">METSRMGTYRTGRHVLNGYIQDGNVQDGKDQDGNVQDGDVQDGYVQDENVQDGKVQGGKVQGGKVQDGYVQDGHVQDENVQDENVRDGKIRDGNVRDGNVRDGNIRDGKIQDGNVRDGNVQDGNVQDGYVQDGNVQDGNVQDGHVRDGNAGMKTSRMEKSRMATSRMATPRMATSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH61</accession>
    <name>A0A401QH61_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01091145">
        <property type="protein sequence ID" value="GCB84724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH61"/>
    <dbReference type="OMA" id="PLHAMDI"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="134" mass="14642" checksum="8493642B0DF1C532" modified="2019-05-08" version="1" fragment="single">MIALDIIVLDIEVRDISILKFRDLSMTALDVIPLDILVLDIIALDIVVLNIIALDIVVLDIIALHIIVLDIITLDIVVLDIIALDIVVLNIVALDIVVLNIVALDIVVLNIIALHIVVLEIMELDIGVLDIIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHV4</accession>
    <name>A0A401QHV4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0025690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01118101">
        <property type="protein sequence ID" value="GCB84969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHV4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019503235" evidence="2">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB84969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9753" checksum="634579D4BB43B8F0" modified="2019-05-08" version="1" fragment="single">RACSCAVHFFVLCLLFEELDDLMEEEDGRLRRLQRSGANENEYAEYNDEEDTVEEVEDAAEDEEDTNEEEQDTVEGIVEEDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIN6</accession>
    <name>A0A401QIN6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01147364">
        <property type="protein sequence ID" value="GCB85233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIN6"/>
    <dbReference type="STRING" id="75743.A0A401QIN6"/>
    <dbReference type="OMA" id="CSGLFWS"/>
    <dbReference type="OrthoDB" id="6155163at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="355" mass="39330" checksum="BB02BC19BEEDDEF7" modified="2019-05-08" version="1" fragment="single">TEALYTDALYTDALDTVALYTDALYTDALYTDALYTVAVYTDAVYTDAVYTEAVYTDAVYTDAVYTEALYTDVLYTTVALYTVALYTDALYTVALYTEALYTVAQCTVALYTDALYTVALYIDTMYTVALYTVALYTVALHTVALYTEALYTEALYTVAVYTDAVYTDAAYTDAVYTVAQYTVALYTVALYTDALYTVAQYTSSTLMLSLYTDALYSVAQYTVVLYTEALYTVALYTDALYSVAQYTVALYTDTVYTDAVYTVALYTEALYTVALGSESLYTVALYTVALYTVALYTDAVYTDTVYTDALYTVALYTDAVYTVVLYIDALYTDAVYTVALYTDALYTVALYTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIT7</accession>
    <name>A0A401QIT7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01141614">
        <property type="protein sequence ID" value="GCB85286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIT7"/>
    <dbReference type="OMA" id="CAYDGDK"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="137" mass="16312" checksum="F96EE788F519BF40" modified="2019-05-08" version="1">MMMSTMVMSTMMIPMYNGDEYNGDEYDGDEYDGDEYDGDEYDGEYDGDEYDDDEYDDDEYDDDYDGDEYDGDECDGDEDDDDEYDGDEYDGDEYDDDEYDGDEYDDDEYDGGEYDDDEYDDDEYDVDEYDYDYDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKD0</accession>
    <name>A0A401QKD0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDNF/GAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01211184">
        <property type="protein sequence ID" value="GCB85845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKD0"/>
    <dbReference type="STRING" id="75743.A0A401QKD0"/>
    <dbReference type="OrthoDB" id="9435188at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF12">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5911" checksum="BD51E29DDA9F202F" modified="2019-05-08" version="1" fragment="single">MLFGPEAKNECIVAVVALQRSPLFDCRCKRAMKKEKQCLAIYWSIHQSLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKR6</accession>
    <name>A0A401QKR6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="Proteomes" id="UP000288216"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <position position="182"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="GCB87238.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="MUCIN-16"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
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            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
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                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007435">
        <property type="protein sequence ID" value="GCB59995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGJ7"/>
    <dbReference type="STRING" id="75743.A0A401NGJ7"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001255">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB59995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1071" mass="123031" checksum="3A6C24366D37768B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGZ0</accession>
    <name>A0A401NGZ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0014126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007466">
        <property type="protein sequence ID" value="GCB60187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGZ0"/>
    <dbReference type="STRING" id="75743.A0A401NGZ0"/>
    <dbReference type="OMA" id="DNRYMHL"/>
    <dbReference type="OrthoDB" id="2429551at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000001">
        <property type="entry name" value="Cystatin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF21">
        <property type="entry name" value="CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="10921" checksum="7C8257EEDE466DEA" modified="2019-05-08" version="1">MCGGTSAEKSATEELQQLANSMKPKIEEEAEKTFDVFVVKSYKTQLVSGTNYFMKIHVGGDDYVHAKVFEDLPCRGSKKEVTGIKVNQLDHNELLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHB2</accession>
    <name>A0A401NHB2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0003909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001108">
        <property type="protein sequence ID" value="GCB60262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHB2"/>
    <dbReference type="STRING" id="75743.A0A401NHB2"/>
    <dbReference type="OMA" id="ESECHCS"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20191">
        <property type="entry name" value="T-box_TBX15_18_22-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000001">
        <property type="entry name" value="T-box transcription factor TBX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF98">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="120"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="310" mass="35059" checksum="922150E10C6BF96B" modified="2019-05-08" version="1">MSERRRSAAALSSRAHAFSVESLIGTNKKRKIQEWDEKTMELSVDSLNPESGLADTVDSSQCMEVNSESQLSSDQEQSPGAEGESPTQHTACSYSSPTELTPNSTTSLPTSSMDEIQMELQCVDLWKRFHDIGTEMIITKAGRRMFPAIRVKITGLDPHQQYYIAMDIIPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSELCPTKPVPGGEGVKTFTFPETVFTTVTAYQNQQVCSLIANIVRKERMRFKHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJM7</accession>
    <name>A0A401NJM7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002450">
        <property type="protein sequence ID" value="GCB61088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJM7"/>
    <dbReference type="STRING" id="75743.A0A401NJM7"/>
    <dbReference type="OMA" id="FTWKDSE"/>
    <dbReference type="OrthoDB" id="7735366at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057439">
        <property type="entry name" value="ANG-1/2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25443">
        <property type="entry name" value="ANG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="9">
        <location>
            <begin position="214"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB61088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="435" mass="49671" checksum="BA020C877BD5ED67" modified="2019-05-08" version="1">MSNSLQRDAPLPVEPNWSQKRLQQLEGILENNTQWLYKLENYIQDSVKTEIVEIQRNAAQNQTAAMLEIGTNLLTQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTNKLEKEIMVQTQEITKLHEKNSFLERKVLEMEGKHETELQSIKAERLKMQDLLMKQSVIIGELEKQLSAATQNNSILQSQQVSLMETVHNLLNMVSHGNDIPRVSRDEVVFKDCAEVYKSGLTTNGVYPLHIPNTTETVKAFCHMEINGGGWTIFQHREDGNVDFHRNWKEYKLGFGDPSGEYWLGNEFVHQLTSQSPHVLRIQLKDWNGNEAFAVFDHFFLGNEEQKYRLHIKGYSGTAGRTSSLSPSGTKFSTKDSDNDECGCNCSQMASGGWWFQACGPSNLNGMYYSGGMNTIRFNGIKWHYWKGSHYSLKSTTMMIRPVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJP3</accession>
    <name>A0A401NJP3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006351">
        <property type="protein sequence ID" value="GCB61121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJP3"/>
    <dbReference type="STRING" id="75743.A0A401NJP3"/>
    <dbReference type="OMA" id="VQTDMSI"/>
    <dbReference type="OrthoDB" id="8750280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="271" mass="31302" checksum="702F2FA771532967" modified="2019-05-08" version="1">MSGSKAEPRLSVPHTDSLTKSEIKRLLQKYKRERDEATRRGEVSRDKLHAIEAATRAQIRELKEKVNTLNSENKSLNKTIKKLQPELQLDGSTRLRSKLTREVVRELKERAEQGKMLLQGNTRLNQQIEQLLADLAQAEGARKLLEDSLQVAQSRVKSLTQENERVLKLWQEGQIEREQALRINRFFRQSLFNKPKSCLTLDKCIQTIASIPISRRFQKRNTEGIVKQRELHQQTMKMKQKFVNRVSVIPQENRGSNSAKSSPSICRISPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK36</accession>
    <name>A0A401NK36_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Immunoglobulin I-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006367">
        <property type="protein sequence ID" value="GCB61222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK36"/>
    <dbReference type="STRING" id="75743.A0A401NK36"/>
    <dbReference type="OrthoDB" id="6244905at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin I-set" evidence="1">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13250" checksum="1C16AF11EC0CC471" modified="2019-05-08" version="1">MIAPRGRRKFDRFQYKTETDSHIANCSLENERNIKRGNVVLLCFGRDGFSPAPCLAVGSCCALTRRSGSATDLCKSDQSTDGEGLKIKEVEAEDAGTYICKATNGFGSINLNYTLIVISKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKJ6</accession>
    <name>A0A401NKJ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006388">
        <property type="protein sequence ID" value="GCB61385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKJ6"/>
    <dbReference type="STRING" id="75743.A0A401NKJ6"/>
    <dbReference type="OMA" id="TRREISC"/>
    <dbReference type="OrthoDB" id="17335at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016617">
        <property type="entry name" value="ARMC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46840">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46840:SF3">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16797" checksum="9847E18937C3F6DF" modified="2019-05-08" version="1" fragment="single">DHISEDIRILATELYELLNKPLQTDKTRIYNSSSTKKIPAHFFISSANKKAKTITLQIDGLHNMSLASAIAATKILQAHQVVKSENGEEAVVPLNTGISKAEQNLNLPDYLPEDESTEIEHCKAISQTGAKGNTNGKWLNAAANFLTKTFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKV9</accession>
    <name>A0A401NKV9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PR domain zinc finger protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0004103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001186">
        <property type="protein sequence ID" value="GCB61500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKV9"/>
    <dbReference type="STRING" id="75743.A0A401NKV9"/>
    <dbReference type="OMA" id="RVCMEEV"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000015">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF32">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB61500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27844" checksum="F66D8D37016CD82A" modified="2019-05-08" version="1">MLGMYVPDRFSLKPSKVQEGIGLYTARRVKKGEKFGPFAGEKRMSNELDESMDPRLMWEVRGSKGEVLYVLDASNPRHSNWLRFVHQAPTQEQKNLAAIQEGENIFYLAVDDIETDNELLIGYLDSEMEEIEEDEEEEVVSKDEENSNDIQPSGEKEILNDKEGYACPQCESSFQSQDILAEHLQSLHQKPSEEKEFKCRNCGKKFPVKQALQRHLLEPCDPTNKDPYMAKSDVLMFSSISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLJ6</accession>
    <name>A0A401NLJ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003821">
        <property type="protein sequence ID" value="GCB61732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLJ6"/>
    <dbReference type="STRING" id="75743.A0A401NLJ6"/>
    <dbReference type="OMA" id="AWLENIC"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000732">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="103"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="638" mass="71860" checksum="7B708E8BB68E58DC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMB0</accession>
    <name>A0A401NMB0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stathmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the stathmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007737">
        <property type="protein sequence ID" value="GCB62028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMB0"/>
    <dbReference type="STRING" id="75743.A0A401NMB0"/>
    <dbReference type="OMA" id="MPTAYKE"/>
    <dbReference type="OrthoDB" id="5986631at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030514">
        <property type="entry name" value="Stathmin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF17">
        <property type="entry name" value="STATHMIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002285">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00563">
        <property type="entry name" value="STATHMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB62028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="178" mass="20629" checksum="A2952D5E4F50800B" modified="2019-05-08" version="1">MSSTVAAYKEKMKELSMLSLICSCFYTQPHPNTINKFGDMEVKAINKRASGQAFEVILKPQSTDLSPDQPVSPKKKEISLEELQQQLDAAEDRRKSQEMQLLQQLAEKQQHRRIVLHRAIVDNCDFSRTTERKLNQKMEVCNENRKAHIAALKDRLREKERHAAEVRRNKVLREELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMW5</accession>
    <name>A0A401NMW5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001236">
        <property type="protein sequence ID" value="GCB62248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMW5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB62248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="10932" checksum="88F33A9F233EDC23" modified="2019-05-08" version="1">MQARQKLCLHGSCTGSTKTCRQMGQRSSSSKQLFQFSAILDKKRSLFSKIQKETALTAQLSPALRPSTNLRGEGAGCFQSLPKMTRRILTRTQGKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMZ8</accession>
    <name>A0A401NMZ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Katanin p80 subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0009485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003880">
        <property type="protein sequence ID" value="GCB62224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMZ8"/>
    <dbReference type="STRING" id="75743.A0A401NMZ8"/>
    <dbReference type="OMA" id="VVLHWVQ"/>
    <dbReference type="OrthoDB" id="8754475at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042404">
        <property type="entry name" value="KATNBL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14682">
        <property type="entry name" value="KATNB1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14682:SF1">
        <property type="entry name" value="KATNB1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="5">
        <location>
            <begin position="150"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="309" mass="34952" checksum="EE407AD639738B4F" modified="2019-05-08" version="1">MASRHQNDRKGVLLFSLEEQLIEKRQLGKRMHPDCSETMKKVRITECKEATPEIKRSSTGQTEKTLHRTSKATCCKKKTRRRVQSNVSNGKQHPSFQGCDMANKENEVVCSGTAPKLSDDNRRSLMNSSDSASRAGTSVTYADYFAQISKDHATMTQVLFGRNLRLNVALTFWQKSASELVAYLVRIQDIAVIADCLPVLTKSLEEEKQSISVGCCVDLLPLVQELLRSRFEEYLIAGLNWLQAVLKQWWPELSAGTKDNDEAHVEDRNIKALKEQLRQLREQGFHLSSVPGSTGKVAKCVETYLERLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN08</accession>
    <name>A0A401NN08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adhesion G protein-coupled receptor B N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000002">
        <property type="protein sequence ID" value="GCB62234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN08"/>
    <dbReference type="STRING" id="75743.A0A401NN08"/>
    <dbReference type="OrthoDB" id="5989160at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043838">
        <property type="entry name" value="AGRB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19188">
        <property type="entry name" value="AGRB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adhesion G protein-coupled receptor B N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="204" mass="22822" checksum="AD66CEAEA01DA63E" modified="2019-05-08" version="1">MVFASNSSACSWIIQNPDPRRYTLYMKVAKSSNVCERRQIRTYQFDSFLASTRTYLGMESFDEVLKLCDPSARYAFLQSSKQYLQMKQVAPGGGGRPRDRGGRVKDKEFSAEYLVVGNRNPSKAACQMLCKWLETCLAVSTSARPCGIMQTPCSCSRGESLSQSTEMLGLNKKEDTCLKDGVYLEHCIRSPKETSEADSRGKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ29</accession>
    <name>A0A401NQ29_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0000105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Displays low GTPase activity and exists predominantly in the GTP-bound form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000014">
        <property type="protein sequence ID" value="GCB63008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQ29"/>
    <dbReference type="STRING" id="75743.A0A401NQ29"/>
    <dbReference type="OMA" id="QVITCNR"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB63008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22424" checksum="78FFB0A9368284A8" modified="2019-05-08" version="1">MPEQSNDYNVVVFGAGGVGKSSLVLRFVKGTFRETYIPTIEDTYRQVISCDKSVCTLQITDTTGSHQFPAMQRLSISKGHAFILVYSICSRQSLEELKPIYQQILQIKGNIENIPVMLVGNKCDETVKEVDNKVGEALAKEWKCAFMETSAKLNYNVKELFQELLNLEKRRSMSLNIDGKKSKQQKRTEKLKGKCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQN9</accession>
    <name>A0A401NQN9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centlein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007884">
        <property type="protein sequence ID" value="GCB63167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQN9"/>
    <dbReference type="STRING" id="75743.A0A401NQN9"/>
    <dbReference type="OMA" id="KGEMKDR"/>
    <dbReference type="OrthoDB" id="10011458at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010457">
        <property type="term" value="P:centriole-centriole cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038810">
        <property type="entry name" value="CNTLN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18957">
        <property type="entry name" value="CENTLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18957:SF0">
        <property type="entry name" value="CENTLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44921" checksum="8DB931FF86036F67" modified="2019-05-08" version="1">MASTQCDPQLLLEEQVHKLSEELAQCQADKEFVWSLWKRLQVANPDLTQAISLVLEREKQKAEAKDRRVLEILQVKDDKLRELEQQVRCQQKEINNLIQRKIAVDNNIMFVQKEVTDLKEKLKNRSQDYKDAKERALKVEEKTSLLVKNLEKEKQGLSTRCSDLLSDLEKQAAQWKEEKSDIDSKVKILEDELKETRNQVENMHNKCNELSSHLVHQQTGLTRKDAEVTKLRQELQELQGLYKDSVEHTGEQAGVIQQLQALNLDTQKVLRNQDDAHASETKSYQKHYSELNMRYDALTSSEAQHHQRNLSLTAQLYGKEEQINRLLGKLQQALDSKQTATHKTTANCLERVEIIFQLGSFSQLKFRFFRCCDRRAVLKERLESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRQ1</accession>
    <name>A0A401NRQ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prostaglandin E2 receptor EP3 subtype</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Prostanoid EP3 receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prostanoid TP receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thromboxane A2 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0007399</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">Interacts (via C-terminus) with MKLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002675">
        <property type="protein sequence ID" value="GCB63540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRQ1"/>
    <dbReference type="STRING" id="75743.A0A401NRQ1"/>
    <dbReference type="OMA" id="SHYMKTN"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004957">
        <property type="term" value="F:prostaglandin E receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004960">
        <property type="term" value="F:thromboxane receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014827">
        <property type="term" value="P:intestine smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060455">
        <property type="term" value="P:negative regulation of gastric acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000163">
        <property type="entry name" value="Thromboxane A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001244">
        <property type="entry name" value="Prostglndn_DP_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000265">
        <property type="entry name" value="Prostglndn_EP3_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF10">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00428">
        <property type="entry name" value="PROSTAGLNDNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00582">
        <property type="entry name" value="PRSTNOIDEP3R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="40"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB63540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="363" mass="40172" checksum="8C14F4BF1F0C537A" modified="2019-05-08" version="1">MWGGINSSSEQPNSNKSSANECVSVSVIFPVTMMVTGIVGNTLALLLVYRSYHKKENKRKRSFLLIIGALALTDLTGKLLTSPVVISVYVSNRQWSRVDPSGNLCAFFGVCMTTFGLCPLFLAGAMAIERTLAIHAPQYYSNHMTTRLTKLVVLSIWLCVMIFALLPIAGVGRYTLQWPGTWCFINTGNHILGNTIFASTFTVLGITSLLVTVSCNVATIRGLVVRCKKKLSSNKQLERITVETLMQLMGIMCVLCVCWSPLLILMSKMIYTESSSDHCYKPPPDKSSSQSGELQTDCNFLLTAIRLASLNQILDPWVYLLLREILLRKVCQVANAVTNCSVEGFKEIPVTVEARQHLKEQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT62</accession>
    <name>A0A401NT62_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001346">
        <property type="protein sequence ID" value="GCB64076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT62"/>
    <dbReference type="STRING" id="75743.A0A401NT62"/>
    <dbReference type="OMA" id="NKLVITM"/>
    <dbReference type="OrthoDB" id="9971011at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="127" mass="14148" checksum="8032AE478EE02065" modified="2019-05-08" version="1">MAFNGKYELESQENFEELMKALGLSDEVIPKYKDLGNVIEIVQNGNSFQVIYNYGSKVITNELTIGQKSEFVSFTGHRVQALAKLGGENKLVITMEGLTAVMELSGDKMIETLTNGEITARKIRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTB0</accession>
    <name>A0A401NTB0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0009767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004072">
        <property type="protein sequence ID" value="GCB64084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NTB0"/>
    <dbReference type="OMA" id="QPAFIEN"/>
    <dbReference type="OrthoDB" id="120383at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
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        </location>
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    <sequence length="1447" mass="159403" checksum="94EB7C8435E4476B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUP8</accession>
    <name>A0A401NUP8_SCYTO</name>
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            <fullName evidence="2">Trimeric autotransporter adhesin YadA-like head domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Galeoidea</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">MOB kinase activator 1A</fullName>
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        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
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                <person name="Kiyatake I"/>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="25104" checksum="692E564FEE6030C8" modified="2019-05-08" version="1">MSFLFGARSNRTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEQSCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRKELAPLQDLIEKLGSKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY70</accession>
    <name>A0A401NY70_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0007790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002881">
        <property type="protein sequence ID" value="GCB65804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY70"/>
    <dbReference type="STRING" id="75743.A0A401NY70"/>
    <dbReference type="OMA" id="SCAGTHN"/>
    <dbReference type="OrthoDB" id="2163581at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097712">
        <property type="term" value="P:vesicle targeting, trans-Golgi to periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029412">
        <property type="entry name" value="CEP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19K CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14933">
        <property type="entry name" value="CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB65804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="164" mass="19200" checksum="75D99F620435E8E2" modified="2019-05-08" version="1">MAYIPRKCGVKFKPPAIVLIYEDENTKKNRQRLIPVRNFSKFSDCSQAAEQMKNNPRHQVYLNGVSQQQLQKLHQLLRDSLNGLSLDQSLETILRENSINPEEDLNKLDDDELAKKKKIMDELFERNRRKPNDPEFVYDLEVDFPQDGQIESCGWDEEEQGGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY96</accession>
    <name>A0A401NY96_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0000481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01000093">
        <property type="protein sequence ID" value="GCB65849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY96"/>
    <dbReference type="STRING" id="75743.A0A401NY96"/>
    <dbReference type="OMA" id="KYQTAIH"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="305"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB65849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="533" mass="60528" checksum="D06B07A5121341F3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0M4</accession>
    <name>A0A401P0M4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING finger and SPRY domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001516">
        <property type="protein sequence ID" value="GCB66661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0M4"/>
    <dbReference type="STRING" id="75743.A0A401P0M4"/>
    <dbReference type="OMA" id="XARCDAS"/>
    <dbReference type="OrthoDB" id="10017393at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16566">
        <property type="entry name" value="RING-HC_RSPRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12883">
        <property type="entry name" value="SPRY_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035774">
        <property type="entry name" value="SPRY_RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF6">
        <property type="entry name" value="RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019514370" description="RING finger and SPRY domain-containing protein 1" evidence="6">
        <location>
            <begin position="19"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="331"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB66661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61513" checksum="DF84436B2F946C89" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1I5</accession>
    <name>A0A401P1I5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Tyrosine-protein kinase Kit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">scyTo_0007979</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Membrane</location>
            <topology evidence="29">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="29">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002983">
        <property type="protein sequence ID" value="GCB67005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1I5"/>
    <dbReference type="STRING" id="75743.A0A401P1I5"/>
    <dbReference type="OMA" id="ANEECEW"/>
    <dbReference type="OrthoDB" id="6077854at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019955">
        <property type="term" value="F:cytokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038093">
        <property type="term" value="P:Fc receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038109">
        <property type="term" value="P:Kit signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000177">
        <property type="entry name" value="Mast/stem cell growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000025">
        <property type="entry name" value="Platelet-derived growth factor receptor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027263">
        <property type="entry name" value="SCGF_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF46">
        <property type="entry name" value="MAST_STEM CELL GROWTH FACTOR RECEPTOR KIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25305">
        <property type="entry name" value="Ig_PDGFR_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500951">
        <property type="entry name" value="SCGF_recepter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 25 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21 29" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 26" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 25 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19 29" id="KW-0675">Receptor</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 29 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 31" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="33">
        <location>
            <begin position="182"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="32">
        <location>
            <begin position="554"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="666"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="24">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="561"/>
            <end position="568"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25 28">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="636"/>
            <end position="642"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="27">
        <location>
            <position position="897"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="34">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00032147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="RuleBase" id="RU000311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="GCB67005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="947" mass="106369" checksum="A0C2629E6D011652" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1P1</accession>
    <name>A0A401P1P1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 23 member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0013648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007068">
        <property type="protein sequence ID" value="GCB67042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1P1"/>
    <dbReference type="STRING" id="75743.A0A401P1P1"/>
    <dbReference type="OMA" id="GLGFDWN"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB67042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="65374" checksum="4871B5FD7B75672A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P264</accession>
    <name>A0A401P264_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SWI/SNF complex subunit SMARCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0012117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005750">
        <property type="protein sequence ID" value="GCB67225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P264"/>
    <dbReference type="STRING" id="75743.A0A401P264"/>
    <dbReference type="OMA" id="LLLLEXE"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="263"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="433"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB67225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="102804" checksum="B66A46FF1714B8F1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P297</accession>
    <name>A0A401P297_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005752">
        <property type="protein sequence ID" value="GCB67242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P297"/>
    <dbReference type="STRING" id="75743.A0A401P297"/>
    <dbReference type="OrthoDB" id="8939204at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="93" mass="10410" checksum="4D93E3325F575BE3" modified="2019-05-08" version="1">MLGWFKPLSPFQEVVGDKILEEEISFPLRFDEFDQSAGDSKSMTLNDITPNQHQKLNNILGFEVYSMLCVPVTSRATAQVVAMGCAFNKRSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2V0</accession>
    <name>A0A401P2V0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004379">
        <property type="protein sequence ID" value="GCB67442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2V0"/>
    <dbReference type="STRING" id="75743.A0A401P2V0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8460" checksum="506C12F177B01010" modified="2019-05-08" version="1">MWPTVQPKDKVPYEQKASKLKEKYEKEIAAYHGKCKGETGQFSMANPSKEEEEDEDEEEDDEEEEDDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5B5</accession>
    <name>A0A401P5B5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007202">
        <property type="protein sequence ID" value="GCB68286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5B5"/>
    <dbReference type="STRING" id="75743.A0A401P5B5"/>
    <dbReference type="OMA" id="FWKHESK"/>
    <dbReference type="OrthoDB" id="8951267at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21031" checksum="9EDE3561C5436734" modified="2019-05-08" version="1" fragment="single">MRECVLTHHELSSSFNVTLNATFDGFDTALYLAKGCPTSTCEGVENLKRLYVAEKLGCAVLGPTCTYATFQIVTLDTFLEIPIVSAGSFGLACNYKPNVTRILPTARKLSNFFVWLWQDELKIKPYKWDSTYIYKKNETTESCFWYMNGLEAGSDQFSLGLEIKEIIRDPVKFKKIANDPHRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P658</accession>
    <name>A0A401P658_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003122">
        <property type="protein sequence ID" value="GCB68607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P658"/>
    <dbReference type="STRING" id="75743.A0A401P658"/>
    <dbReference type="OMA" id="RDECYTI"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF47">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22246" checksum="F9B5DD1B022BBA64" modified="2019-05-08" version="1">MRRGVLFLGEHDEEYVFTLPCAYARSILTVPWVELGGKVSINCAKSGYSAAVTFHTKPFYGGKVHRVTAEVKYNPTNTIVCKAQGEWNGTLEFTYSNGETKVIDTTKLPVIRKKIRPIKKQGLFESRRLWELVTNALQDGNIGAATEYKHLLEERQRVEERQRAATNTLWKPKYFRKEGDGWVYYSPLWKTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6C3</accession>
    <name>A0A401P6C3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0010442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004503">
        <property type="protein sequence ID" value="GCB68701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6C3"/>
    <dbReference type="STRING" id="75743.A0A401P6C3"/>
    <dbReference type="OMA" id="YFYIDAS"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF2">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE ZBED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="262"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB68701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="96497" checksum="295B4EA75090F363" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6M1</accession>
    <name>A0A401P6M1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA-binding motif protein, X-linked 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0008282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed of at least 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IST3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003137">
        <property type="protein sequence ID" value="GCB68789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6M1"/>
    <dbReference type="STRING" id="75743.A0A401P6M1"/>
    <dbReference type="OMA" id="ACNERSE"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000218">
        <property type="entry name" value="RNA-binding motif protein, X-linked 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="383" mass="45063" checksum="652C8DD731762C67" modified="2019-05-08" version="1">MNPLTKVKLINELNAREAELGVQDKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFICYEDQRSTILAVDNFNGIKIKGRTIRVDHVANYRPPKDSDDIDDVTKRLREEGCAPRAPPSAPVSSESSEEDVSEMTAKKRKKEKKKKKKKEKKEKKFKLAKKESEERATKQLAKSSGRNLSPPPLVRVKSEREDAGYEKYTSTKLDTTQDCSGDRRNDERGRGDARKQTDGVDEMRTREKHNERSRPRNSEREERRRDDQNGRGACNERSERETRFTHGDGRELRNDEERQRDQEKMRKEDRFDRKYDDREKYRKYDRNKREERDSNCDSIKHKERRNDPDNVSHYKGRDNHRDSGHRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P718</accession>
    <name>A0A401P718_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Protein transport protein Sec24B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0005384</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001667">
        <property type="protein sequence ID" value="GCB68908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P718"/>
    <dbReference type="STRING" id="75743.A0A401P718"/>
    <dbReference type="OMA" id="NITNCDD"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="262"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="504"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="600"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="731"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB68908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="96017" checksum="86EB68DE6B5B96E6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7Q1</accession>
    <name>A0A401P7Q1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0008341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01003168">
        <property type="protein sequence ID" value="GCB69167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7Q1"/>
    <dbReference type="STRING" id="75743.A0A401P7Q1"/>
    <dbReference type="OMA" id="FQMVFSA"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF19">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="181" mass="21078" checksum="239CBD071F919498" modified="2019-05-08" version="1">MLAAVGARAAQIYQYLLKGDPRIEEYPLMVSPVPMTTILLFYVYFVLSLGPRLMDGRKPFDLKKIMVVYNFALVFFSIYIVYEFLMAGWATGYTFQCDPVDYSNSPTALRMVRVAWLFLFSKFVELFDTVFFVLRKKNSQITFLHIFHHSIMPWTWWWGVKFGPGTQSSTCRCPKLSKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7R3</accession>
    <name>A0A401P7R3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004548">
        <property type="protein sequence ID" value="GCB69165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7R3"/>
    <dbReference type="STRING" id="75743.A0A401P7R3"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF3">
        <property type="entry name" value="PROTEIN MONOGLYCYLASE TTLL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="250" mass="28674" checksum="0900F655CFA118C0" modified="2019-05-08" version="1">MSCKYLSSFSGHSALLPPFWNELAFHEPLGVCLAAAGRISKRRSKAWRSRKRIVASRSAVNSLSPEAAAGKKNILKCSAEQRLELVTFLAETAVKERKIFTIIGYYPVIRASLRKRGWAERTFPTLKQVARKNGDEDVNPDISRLSIRTWVTKQLTRSDDKLDNQAGDEPLKLQEEEESHFNFNSANNIHHLVSNMLSKEIPYFIWTVRRNAIDCHYLHSDQMINHYAKNASFTTKVRNILWLNAVIIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7W3</accession>
    <name>A0A401P7W3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM129 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004559">
        <property type="protein sequence ID" value="GCB69251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7W3"/>
    <dbReference type="STRING" id="75743.A0A401P7W3"/>
    <dbReference type="OMA" id="RADEHPI"/>
    <dbReference type="OrthoDB" id="10055027at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018801">
        <property type="entry name" value="TM129"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10272">
        <property type="entry name" value="Tmpp129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="361" mass="40915" checksum="9D2DD5FEAD386F71" modified="2019-05-08" version="1">MDSPEAAFSLFYVVLSFCFVFTPTEFRSAGVTVQDLLSDQLGSEDLGFVHYHIRRTAATVTVHSLLPLGYYAGMCVASSGEKQFYFLVSEGWLIYLVTAVLIPAAASLVVLYWSFNKWGNHPISRSLAHYALPQSGWRAVASSVNTEFRRIDKFASGVPGARVIVTDTWVMKVTTYNVHIAQQQDIHLTLTESRQHELCPDLNTPVQVLTIRVCSINPNVKPFDIRLNSTEYGELREKLHTTVRNAHNVVIHQTLSDMFLDTFKIQVELNQRYNLPGNQELEPCIGCMQTAANIKLMKICQEPNEGDCQQCYCRPMWCLTCMGKWFASRQDQQHPETWLSNRVPCPTCRSKFCILDISLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P940</accession>
    <name>A0A401P940_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0005518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001726">
        <property type="protein sequence ID" value="GCB69649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P940"/>
    <dbReference type="OMA" id="CIELCAY"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14365">
        <property type="entry name" value="CUE_N4BP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056718">
        <property type="entry name" value="DUF7816"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056719">
        <property type="entry name" value="DUF7817"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056720">
        <property type="entry name" value="DUF7818"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041801">
        <property type="entry name" value="N4BP2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25124">
        <property type="entry name" value="DUF7816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25125">
        <property type="entry name" value="DUF7817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25126">
        <property type="entry name" value="DUF7818"/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Yamaguchi K"/>
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                <person name="Tatsumi K"/>
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                <person name="Motone F"/>
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                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
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            <dbReference type="PubMed" id="30297745"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    <comment type="similarity">
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    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15869">
        <property type="entry name" value="R-SNARE_VAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042887">
        <property type="entry name" value="VAMP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46897">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46897:SF1">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="192" mass="22343" checksum="C50F0333C5CFFF19" modified="2019-05-08" version="1">MFENHRSKQQVPVLPSCKKGMALRYCPVGFLTSWTLVALQVEEIKFHQAVIMPPKFKRHLNDDDVTGSIRSERRNLLEDDSDEEEDFFLRGPTAPKFGQKNDKIKHVQNQVDEVIDVMQENITRVIERGERLDELQDKSESLSDNATVFSNRAKQLRRQMWWKECKMKVIISVVVVIVLLVIIIPVILKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAE1</accession>
    <name>A0A401PAE1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000256">
        <property type="protein sequence ID" value="GCB70060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAE1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="180" mass="19709" checksum="0C2301AB65E3C151" modified="2019-05-08" version="1">MLEWTKSTPELLEESPVNLYEVEDPSELQDISLSTSGEENDRSAGEVSFATTEQHTERMEGQASLPSNIERATVDNTPATAFATFPEEEVDSIDLESLLDSEIINSTGHLSMPFPSSKESDSLLSNIEGSTVDNTPARAFGNIPGDPGEEEMDSIDLESSSDSRERQVHRICICAILEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAE8</accession>
    <name>A0A401PAE8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0001200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 6 7">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000258">
        <property type="protein sequence ID" value="GCB70099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAE8"/>
    <dbReference type="STRING" id="75743.A0A401PAE8"/>
    <dbReference type="OMA" id="PPCGIHP"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003090">
        <property type="entry name" value="Alpha-crystallin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF27">
        <property type="entry name" value="HEAT SHOCK PROTEIN BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00525">
        <property type="entry name" value="Crystallin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="9">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB70099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="185" mass="21102" checksum="597CC6AD8FDB793C" modified="2019-05-08" version="1">MEDKTIAHAYPMSVEYEKDTPTTIYDQNFGEGLSPEDILAPTLYHGYYIRPRINKQLDRGFSTIETKHHKFQVFLDVCQFLPDEISVRTVDNLLEVSGRHPQKLDSHGFISRDFTRTYILPLDVDPLLIRSTLSHDGVLCIEAQRKGDEIQPNITNVKINVEPPPMAKESGANNNKEEEKDKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAP4</accession>
    <name>A0A401PAP4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003281">
        <property type="protein sequence ID" value="GCB70184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAP4"/>
    <dbReference type="STRING" id="75743.A0A401PAP4"/>
    <dbReference type="OMA" id="MECQERE"/>
    <dbReference type="OrthoDB" id="10252347at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035148">
        <property type="term" value="P:tube formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031887">
        <property type="entry name" value="SDCCAG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34343">
        <property type="entry name" value="SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34343:SF1">
        <property type="entry name" value="SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15964">
        <property type="entry name" value="CCCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="424" mass="48810" checksum="BBC385CB9A97DDEA" modified="2019-05-08" version="1">MKDSSDTEEDLDLYLKGLRERANLVPIINDQSEYIQHLEAEVKLFKEELSSVEQRVQVVVVENEKLGEELRSRADQATLNEPSACPFSPNSQETCPVDPMTIKTVEAPESASPAKSMNQSCFTLTQSESKTVAEEIKKLQLEVENLNILYHKKTKTLETQVSLLRKDLSDSHMECQEREERLKIQESLLAMDSSERVAGLCLKCAQHEAVLARTHSNPELKAVERLRKERDDLMNLLATLRSNVIEMQAREDSACRQVKQATEVAEEANLEKIQALVHCEQLKNEMLRQKERLERELGSQQEKIANAKKAVHEEMRKEREALASKVTCLSENVACLEGQLQRLVRERDSVCNQLEEAQKKLTNHELEINQESGELRYQLNQVKMEKEEVEKEFRDYKTKMLRELELREQVGVSISVRNCFMRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAR2</accession>
    <name>A0A401PAR2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004681">
        <property type="protein sequence ID" value="GCB70216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAR2"/>
    <dbReference type="STRING" id="75743.A0A401PAR2"/>
    <dbReference type="OMA" id="FRWARII"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF52">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE FETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB70216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="305" mass="35236" checksum="6204490C419926EF" modified="2019-05-08" version="1">MCRFLRYFFYKNFAFTFVHFWYGFFCGFSAQTVYDEWFITLYNLVYTSLPVLAMSLFEQDVNDRWSMAYPQLYEPGQFNLYFSKLAFVECIIHGVYSSLVLFFIPYGALFEAERDDGKTVSDYQSFALIAQTCLLVAVTLQIALDTTYWTAINHFFIWGSLAVYFAITFTMYSNGMYLMFPTSFPFIGTARNALNQPHVWLTIFLTAVMCVLPVILVRYLKGELKPTFSNKLRCRICQMKMIPPKQAISRLKRPSVRRSAYAFSHQRGFGALITSGKNMRIRTGEADTTGLLYYNNVALELLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAS7</accession>
    <name>A0A401PAS7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003287">
        <property type="protein sequence ID" value="GCB70223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAS7"/>
    <dbReference type="STRING" id="75743.A0A401PAS7"/>
    <dbReference type="OMA" id="QCEKYPR"/>
    <dbReference type="OrthoDB" id="125906at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026295">
        <property type="entry name" value="CCD81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14362">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14362:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="380" mass="44819" checksum="2052D97BCB0B37E2" modified="2019-05-08" version="1">MMAVTSSRQNIFRLASPHRSSSCQPGIQHTNLQALKRKTPPATTCSDHCRAGQELCYLCMQRALKNFPIDLSENRRIKEEENEQILHQYQQIKDQDTLFQQQCEMLAKREFNQKISAFNIGVAEAKKELKNSKCKASRNGYIFQRRLLTPPVFLKQQQYAQCLTKQIQEKKQREEKKKQDDEFLDRLEQVQLAEDLAVQRQHFQKEKQEQTEAYKKALDFQRKYKPRQLPASVPDSVEPIFGSSDSLGRTEEQKQEAYNLYNEQMKAAADRKRIAILNELYEQKTESDLLERNRKSLINEHKKRYENLQRIHKTLEEAWNDNVIMKQLKDYEENQYSKAGGLFLLDQCNKYRRCFQCKRRLSNSGQTNIWSNSFITTGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB73</accession>
    <name>A0A401PB73_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0001262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000275">
        <property type="protein sequence ID" value="GCB70374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PB73"/>
    <dbReference type="OMA" id="ANEMFTT"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21243">
        <property type="entry name" value="CH_SYNE1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000033">
        <property type="entry name" value="nesprin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000139">
        <property type="entry name" value="nesprin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000089">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047291">
        <property type="entry name" value="CH_SYNE1_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057057">
        <property type="entry name" value="Spectrin_SYNE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514:SF3">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514">
        <property type="entry name" value="PKA ANCHORING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25034">
        <property type="entry name" value="Spectrin_SYNE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="144"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1262"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1563"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1892"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2068"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="2215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB70374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2215" mass="255028" checksum="5E4767E1FB8857E3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBV2</accession>
    <name>A0A401PBV2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L39, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mitochondrion-specific ribosomal protein mL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001827">
        <property type="protein sequence ID" value="GCB70597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBV2"/>
    <dbReference type="STRING" id="75743.A0A401PBV2"/>
    <dbReference type="OMA" id="KVFWTIE"/>
    <dbReference type="OrthoDB" id="5870821at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000006">
        <property type="entry name" value="39S ribosomal protein L39, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB70597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="284" mass="32099" checksum="BEB7287CE7506C7F" modified="2019-05-08" version="1">MNPLCFQKCELLDPVTLSACSLSLCTDMSEWCVKRSILALVDGEIWDMYKPLNKSCDIQFLTFKDENPDEVNKAYWRSCAMMMGCVLETAFKDEYSVELIRAPDVPVISGAFCYDVILDGRLDDWTPSAENLRSLTKEAHQLIHKDLPFECLEVAPKVAVEIFPDNKHKLAAIEEQASLHPNKLVKLYRCGDFVDISNGPHISRTSVCSQYEITATHNLDTTQSGLVRRFQGISLPLHLKALFAVWERLRQRSQKLITEDQSSKRDSGSKSIVSKLHRETGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC56</accession>
    <name>A0A401PC56_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003354">
        <property type="protein sequence ID" value="GCB70688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC56"/>
    <dbReference type="STRING" id="75743.A0A401PC56"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="124" mass="14054" checksum="B4120DC4548A6F11" modified="2019-05-08" version="1">MVGPLAKDVESLALCMKALLCEDMFHLDPTVPPIPFNNEIYANIKQMRIGYFESDGYWIPTPSMKRAIMETKQLLEEAGHTLVSFTPPKMYYAMNEIVFPGIFADKGLTLIETLVPESQMVSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDE0</accession>
    <name>A0A401PDE0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004826">
        <property type="protein sequence ID" value="GCB71138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDE0"/>
    <dbReference type="STRING" id="75743.A0A401PDE0"/>
    <dbReference type="OMA" id="YVGCIRE"/>
    <dbReference type="OrthoDB" id="5983569at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB71138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="12421" checksum="6BF6F31AA3CAB96C" modified="2019-05-08" version="1">MGQWYQLPPINQGGDCVIEVGVAGGVPIQRREFCPQHMSQGSFGPIYLGASPVDTDILQGMGHVQSYIGCIRELQVNDNELSILEEAVRGKNIVNCDVSICDYHPCKNGATCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDM8</accession>
    <name>A0A401PDM8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004837">
        <property type="protein sequence ID" value="GCB71212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDM8"/>
    <dbReference type="OMA" id="RTAKECH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="211" mass="27919" checksum="FE12438118696A10" modified="2019-05-08" version="1">MEKERREKEEREEKERREKEGREKKKGERARRKRNREWRKRERKKGERERKIKEKKRERKKGERERERRKRERRERRKKGEREDREKEERREKGEREERERRERERERKEKERCDEGERERDRERRKRERKRGERKKAEREREESEIGEREREKGERERKIKERKKGERERERRERERRKKKEERREKGEREERERRQRGERENGREREKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF83</accession>
    <name>A0A401PF83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0001703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000393">
        <property type="protein sequence ID" value="GCB71793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PF83"/>
    <dbReference type="STRING" id="75743.A0A401PF83"/>
    <dbReference type="OMA" id="MCSQTEN"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="264"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB71793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="813" mass="92696" checksum="F0E69E083688D85B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFS1</accession>
    <name>A0A401PFS1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0001772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000410">
        <property type="protein sequence ID" value="GCB71971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="75743.A0A401PFS1"/>
    <dbReference type="OMA" id="RWQTASV"/>
    <dbReference type="OrthoDB" id="10053234at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:terminal bouton"/>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:dense core granule priming"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
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    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
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    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
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        <property type="term" value="P:synaptic vesicle priming"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="C2 domain"/>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MHD1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="6">
        <location>
            <begin position="122"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="278"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB71971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50905" checksum="8B1AD9087B86685D" modified="2019-05-08" version="1">MTRRQFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPLIVGHYMRRFAKTISNVLLQYAEIIAKDYASYCSKEKVPCILMNNIQQLRVQLEKMFEAMGGKDLNAEASDILKELQIKLNNVLDDLSRVFALSLTLFAKICEKTVLKRVLKELWKIVMNIMEKTIVLPPLTDQTGTQLIFNAAKELGQLSKLKDHMVREEAKSLSPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDTLIKTFIQSQSSQGSGVDDPVGEVSIHVELFTHPGTGEHKITVKVVAANDLKWQTTGIFRPFVEVNMIGPHLSDKKRRFATKSKNNSWAPKFNETFQFTLSAEDGPECYELQICVKDYCFAREDRSVGIAVMQLHDIIQKGSCACWLPLGRRIHMDETGLTVLRILSQRNNDEVAKEFVKLKSDIRSAEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFZ6</accession>
    <name>A0A401PFZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0006155</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002026">
        <property type="protein sequence ID" value="GCB72053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PFZ6"/>
    <dbReference type="OMA" id="HETTGQK"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000001">
        <property type="entry name" value="Collagen alpha-1 type I chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019487548" description="Fibrillar collagen NC1 domain-containing protein" evidence="12">
        <location>
            <begin position="24"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="13">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="14">
        <location>
            <begin position="1129"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="782"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="866"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB72053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1364" mass="131786" checksum="E55E785ECD200F74" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG52</accession>
    <name>A0A401PG52_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002034">
        <property type="protein sequence ID" value="GCB72107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG52"/>
    <dbReference type="OMA" id="EGGCKVK"/>
    <dbReference type="OrthoDB" id="9428439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007158">
        <property type="term" value="P:neuron cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026995">
        <property type="entry name" value="Astrotactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16592">
        <property type="entry name" value="ASTROTACTIN-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16592:SF9">
        <property type="entry name" value="ASTROTACTIN-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019484347" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="9854" checksum="BE7E1429F5908E0C" modified="2019-05-08" version="1">MAVRAALRALLGCLLATVAPAEISKEGGCKVKTVTVSTLPVLRENDISFHGALAAESKLFLFVRNDLPGEILVVDDLENTELPYFTLGLPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH89</accession>
    <name>A0A401PH89_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrator complex subunit 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002113">
        <property type="protein sequence ID" value="GCB72481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH89"/>
    <dbReference type="STRING" id="75743.A0A401PH89"/>
    <dbReference type="OrthoDB" id="9949257at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048662">
        <property type="entry name" value="IntS11_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21386">
        <property type="entry name" value="IntS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 11 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="65" mass="7263" checksum="11D4C1D81A4F2E79" modified="2019-05-08" version="1" fragment="single">ILKDYPIQHLPDGSVMVESILIKISAMSEDQSTKDVLVSWTYQDEELGSYLITLLKKGLPQSIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJI4</accession>
    <name>A0A401PJI4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002308">
        <property type="protein sequence ID" value="GCB73293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJI4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB73293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="178" mass="19673" checksum="DB25F4762951A841" modified="2019-05-08" version="1">MTIVRTHLRGKRPNVRLKHWRRSYVDIRLLVGPVRTCLISSMGTRTQIELACGSPLRCIQEMLDPILEDLDQNRPPLELMPPSQSLPLVLGAPAMEQLISDVENAEMPDEDPLSSHFEVDMDILPPPEPMASISLATPAPTTPAGSTGKRLSPVWYTPPDATCSALDGRAWLGSLRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLQ4</accession>
    <name>A0A401PLQ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RING2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">RING finger protein 1B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">RING finger protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase RING2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0003144</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01000839">
        <property type="protein sequence ID" value="GCB74060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLQ4"/>
    <dbReference type="STRING" id="75743.A0A401PLQ4"/>
    <dbReference type="OMA" id="PTEMTGD"/>
    <dbReference type="OrthoDB" id="337575at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17167">
        <property type="entry name" value="RAWUL_RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16740">
        <property type="entry name" value="RING-HC_RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000067">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000100">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037937">
        <property type="entry name" value="RING2_RAWUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0678">Repressor</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="222"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB74060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="424" mass="47394" checksum="CF2A8C173440B3ED" modified="2019-05-08" version="1">MSLREESGCRESLIPDADCFPNVHCGDSPYCEYCGAPGLFTPGEGERERASEPENPVFIPLPSLQDAMAQVVQTNGTQPLSKTWELSLYELQRTPQEAITDGMEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARISKHHNQQALSHSIEEGLKMQALNRAQRVRKHQAENGSGAEDNGDSSHCSNASLHSNQEAGPSQKRAKTSDDSGPDLDTTNENGTGDPDPVTDGTNEIELVFRPHPTLVEKDETAQTRQVTVGVQRIVGRTPVSRKRYIKTTGNATVDHLSKYLAMRLALEELRKNEEANPMNVETVSEKQYTIYIATVNGQFTLLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMH6</accession>
    <name>A0A401PMH6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Interleukin-1 receptor-associated kinase 1-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0003416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IRAK1BP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000922">
        <property type="protein sequence ID" value="GCB74327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMH6"/>
    <dbReference type="STRING" id="75743.A0A401PMH6"/>
    <dbReference type="OMA" id="KEHVNDV"/>
    <dbReference type="OrthoDB" id="6365554at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.170">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2970">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030312">
        <property type="entry name" value="IRAK1BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18842">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18842:SF2">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB74327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27694" checksum="5BBC02AEAA0CA4EB" modified="2019-05-08" version="1">MAITPAQVFASLLSDQEKSKRCRSEYRGAQSPHSSPAGEREVQVSASAEVTAPPNRARLCVLVGSRKEAAAAAKSSVNRRLDYILQSVRAHGVREDSVTVTKDFRRVENAYQMEAEVCVIFSDFGKMENLCNLFVEKLDSSVVVGSPQFYHTTEAVETIRRQACLRAVANSRRKAFEVCRLLGQTLGRPLIVREEETKESDGLTSETATPDNMRSLTIQQQINNASMTVCSKVFVTFELKSKDNLKRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNS2</accession>
    <name>A0A401PNS2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0003849</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001080">
        <property type="protein sequence ID" value="GCB74758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNS2"/>
    <dbReference type="STRING" id="75743.A0A401PNS2"/>
    <dbReference type="OMA" id="HGGATEW"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF105">
        <property type="entry name" value="SODIUM BICARBONATE COTRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="18">
        <location>
            <begin position="125"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="17">
        <location>
            <begin position="468"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="422"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB74758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1142" mass="128748" checksum="27996D238CC87851" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPP2</accession>
    <name>A0A401PPP2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0019726</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014974">
        <property type="protein sequence ID" value="GCB75120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPP2"/>
    <dbReference type="STRING" id="75743.A0A401PPP2"/>
    <dbReference type="OMA" id="MRFNKSA"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005343">
        <property type="term" value="F:organic acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015730">
        <property type="term" value="P:propanoate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF25">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB75120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="12765" checksum="A3CB51B04250F07A" modified="2019-05-08" version="1" fragment="single">YLNMRFNKSARYIGTTFYIIQTVLYTGIVIYAPALALNQVTGLDLWGVLVATGLVCTFYCTLGGLKAVVWTDVFQMGIMIAGFLAVIIRGVVIQGSFERIWNISYHGGRLNFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ62</accession>
    <name>A0A401PQ62_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 DOCK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011158">
        <property type="protein sequence ID" value="GCB75260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ62"/>
    <dbReference type="STRING" id="75743.A0A401PQ62"/>
    <dbReference type="OMA" id="HFCCCIS"/>
    <dbReference type="OrthoDB" id="8625636at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000045">
        <property type="entry name" value="Dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF4">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="213" mass="24559" checksum="615A106279CF4452" modified="2019-05-08" version="1">MYHNNSPRWGEIVKLPIPVDKFRGSHLRFEFRHCSTKDKGEKKLFGFAFTPLMRDDGTTLSDDVHELYVYKCDENSTFSNHGLYLGLPCCKEDFNGCPNIPSSLIFQRSTKEFFWISTLLSSTKLTQNVDLLALLKWKAQPDRVMDILGRLRHVSGEEIVKFLQDILDTLFTILDDNTEKYGLLVFQSLVCIINLVSYILKHFLELSEVKTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQC9</accession>
    <name>A0A401PQC9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011166">
        <property type="protein sequence ID" value="GCB75307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQC9"/>
    <dbReference type="STRING" id="75743.A0A401PQC9"/>
    <dbReference type="OMA" id="ANECIRI"/>
    <dbReference type="OrthoDB" id="9887129at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000465">
        <property type="entry name" value="Granulocyte colony-stimulating factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000524">
        <property type="entry name" value="Interleukin-6 receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015152">
        <property type="entry name" value="Growth/epo_recpt_lig-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010457">
        <property type="entry name" value="IgC2-like_lig-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09067">
        <property type="entry name" value="EpoR_lig-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06328">
        <property type="entry name" value="Lep_receptor_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019030580" description="Fibronectin type-III domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="125"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB75307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="258" mass="28840" checksum="AF08966F7183261B" modified="2019-05-08" version="1" fragment="single">SITPLFCLVHLLSLRTGAVLEANECIRILVSTDTVQWGSPLAAICAITNASCDVVSLTNASKIFWQLNKVDIPRTQYTILNRTVSQVNIPVFNQTVGMLSCQIHQGPGVTLRNDVRIRTGLPPDKPVNLTCVTSWKKEPSMKCSWNPGRHPHLPTNYTLRRIKNLGKCHNHEVNGERIDCLSRDSHSCTVPREKLRLFSTYDISVFAENILGSVESDILCIDAMDVVCSRIEVRNPTLQYLRPLHSDPETAIIDNLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQK0</accession>
    <name>A0A401PQK0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009903">
        <property type="protein sequence ID" value="GCB75392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQK0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="16387" checksum="3A0C44357E125CB5" modified="2019-05-08" version="1">MGVGVLELKNELVVPAAVGVVPAAVGVVPAAVGVVPAAVGVVPSAAVGVVPAAVGVVPSAVGVVPSAAVGVAPAAVGVVPAAVGVVPSAVGVVPSAAVGVVPSAAVVLASGAAVVPAAGAAGVVPAAVVVPAAGVQLKGSKLEVTNAWFIRNPKCWLLAKIMQLKGSCTSTEGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR45</accession>
    <name>A0A401PR45_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016389">
        <property type="protein sequence ID" value="GCB75606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR45"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="109" mass="12747" checksum="DD2F7B08F4689B6B" modified="2019-05-08" version="1">MEDYSVLIEDPLLVIEDPLLLIEDGLLFTEDPYLLIEYTLLLIEDVLLLIEDPLFLIGSIEDHLLLIDDPLMLIYDRLLSTEYPRLLIDDPLLLIEDEFVVNQWSFDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRP0</accession>
    <name>A0A401PRP0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016429">
        <property type="protein sequence ID" value="GCB75780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRP0"/>
    <dbReference type="OMA" id="HTDPPTY"/>
    <dbReference type="OrthoDB" id="10069841at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="16960" checksum="25AE641D5981E456" modified="2019-05-08" version="1">MINPLIDSLIDSLIDTLIDSLIDPLIDPLIDSLVDSLTDPLIDPLSDCLIHSLIDPPIDSLIDTLIDTLIDPLFDPLIDSLTVPLIDPLIDPLSDSLIDSLIDPLIDSLIDTLIDSLTDPLIDPLSDHLIDSLIDPIIYSLIDFLIDTLIDPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS97</accession>
    <name>A0A401PS97_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013870">
        <property type="protein sequence ID" value="GCB76009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS97"/>
    <dbReference type="STRING" id="75743.A0A401PS97"/>
    <dbReference type="OMA" id="RFLFCKR"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003851">
        <property type="term" value="F:N-acylsphingosine galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006682">
        <property type="term" value="P:galactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF54">
        <property type="entry name" value="2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB76009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21798" checksum="CCC70D0397A12D84" modified="2019-05-08" version="1" fragment="single">GHPNIRGFLSHGGLNGIFEAMYHGVPVVGIPLFGDHYDTMTRVHAKGMGISINWKTMTEDDLYNAMLAIITDPRYKQRAEQLSQIHRDQPEHPVSRTVYWINYILRYSGAEHLRAAVYNVRFYQYFLLDAVLLISLSTVAILKIGLWIAKQVAKRFSSKFVHGKTNGHCYNGIANGKHRKNGHVKHEKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSD2</accession>
    <name>A0A401PSD2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0017410</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Converts big endothelin-1 to endothelin-1.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer; disulfide-linked. Interacts with PPP1R16B. Interacts with TSPAN8; this interaction recruits the endothelin converting enzyme ECE1 to tetraspanin-enriched microdomains and positively modulates its enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011292">
        <property type="protein sequence ID" value="GCB76003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSD2"/>
    <dbReference type="STRING" id="75743.A0A401PSD2"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000076">
        <property type="entry name" value="membrane metallo-endopeptidase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF130">
        <property type="entry name" value="ENDOTHELIN-CONVERTING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="19">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB76003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="161" mass="18240" checksum="7AF521EAFD6F271F" modified="2019-05-08" version="1">MEALRESVVHLALQMSTYKRATFDEDDLIDSTVDEVYPEGHQMNFRKPKGLKGCWADRTHLEKRLLVVIIVLALLLFSSILALVYKYGSSPKVCLTESCVIVASNVLKSLDRSVDPCHNFYNYACGGWIKANPLPDGKSRWGTFNNLWDHNQAIMKHLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTG2</accession>
    <name>A0A401PTG2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008801">
        <property type="protein sequence ID" value="GCB76392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTG2"/>
    <dbReference type="STRING" id="75743.A0A401PTG2"/>
    <dbReference type="OMA" id="NKLPYLW"/>
    <dbReference type="OrthoDB" id="9929362at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="159" mass="18425" checksum="8CCE90DC51EAC5E0" modified="2019-05-08" version="1">MIERGIQIVSNMEISKDQRGDEQEHHDRIRDMTKLLLFLAVLVNFQNVYLGKPLTSEKFVSVDSMFPAREAPFPRNSHTLARSIDVQNSSQQPSMCYFLQESDLESQISCKLRFTRSKFNFNPFGLRFGKRDDAGSVNWKTLVVNGNKLPYLWKHKVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTR8</accession>
    <name>A0A401PTR8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011386">
        <property type="protein sequence ID" value="GCB76507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTR8"/>
    <dbReference type="STRING" id="75743.A0A401PTR8"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="311" mass="32798" checksum="F44A324E5218B8EC" modified="2019-05-08" version="1">MLLYFLLTVKMSLAAPLNKDVYKLPPSALEELSSKGTIILEAALKNALLVLDEVLKKRNLHLKECNYCAVCLFKHCSNRTTQCVSGVPPTSEPSCDIISRAQLLEAEAERQWELSKACWYYQTYCPEGGHRIMGCLKQMEEHCHARILQCSEAYRGVVLMRSVHKRVAAAVVTAAEGRAAAEGRAAAKGRAAAAATAAEGRAAAAATAAEGRAAAEGRAAAEGRAAAEGRAAAEGRAAAEGRAAAEGRAAAEGRAAAQGQAAAGQVAPTQAAGSPARQAQEDDNNEGKAQDEDTNVDEEQKEEEEEVVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU01</accession>
    <name>A0A401PU01_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloproteinase inhibitor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Tissue inhibitor of metalloproteinases 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0021014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017902">
        <property type="protein sequence ID" value="GCB76597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU01"/>
    <dbReference type="STRING" id="75743.A0A401PU01"/>
    <dbReference type="OMA" id="PFGKCET"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03585">
        <property type="entry name" value="NTR_TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.370.10:FF:000001">
        <property type="entry name" value="Metalloproteinase inhibitor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027465">
        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF22">
        <property type="entry name" value="METALLOPROTEINASE INHIBITOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="6" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="7" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="NTR" evidence="12">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB76597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19808" checksum="F1D103A3C1452213" modified="2019-05-08" version="1">MRAKVVGKKLLKDGPFGTMRYTIKQMKMYRGFSKMQQVQYIYTEAAESLCGVRLQVNKFQYLITGRVFDGKVYTGVCNFIVPWDRLTLSQRKGLNHRYQYGCNCKIKPCYYLPCFVTAKNECLWTDMLSDQGYMGHQAKHYVCIRQKEGYCSWYRGAAPPDKTRINATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU45</accession>
    <name>A0A401PU45_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008844">
        <property type="protein sequence ID" value="GCB76660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU45"/>
    <dbReference type="STRING" id="75743.A0A401PU45"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019053634" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10133" checksum="A7EF565A60DABBE1" modified="2019-05-08" version="1">MWTILITILWVSISAQPSEGGTLTTQRGIPCPRVHGDGWKVQNQEQYANISGFNLLRRFSLFKTPAVKKIKNPTGSLIVKLGKLSLVRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUE6</accession>
    <name>A0A401PUE6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008866">
        <property type="protein sequence ID" value="GCB76766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUE6"/>
    <dbReference type="STRING" id="75743.A0A401PUE6"/>
    <dbReference type="OMA" id="CHAPNDP"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF3">
        <property type="entry name" value="DELPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="299"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="690" mass="77632" checksum="7B13D5B714328C0E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUK5</accession>
    <name>A0A401PUK5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine N-acetyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014026">
        <property type="protein sequence ID" value="GCB76753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUK5"/>
    <dbReference type="OMA" id="FESSMWH"/>
    <dbReference type="OrthoDB" id="8889733at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056483">
        <property type="entry name" value="Hisat_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403">
        <property type="entry name" value="LOC100145250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403:SF6">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24066">
        <property type="entry name" value="Hisat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine N-acetyltransferase C-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="167" mass="18683" checksum="BBCE6642AE5895C6" modified="2019-05-08" version="1">MKKRGDEYYEPIPLQPDDVPSIFLNRTVIDTLLPGGRIIQRGSVFKPLESNLDILLSRDIVWRADRKGNPRALSLGSAPNRGPMGNRIFVIDVFGDDLSAVKSVFLSQLQSLPPLQDNVICLLSVNPSLSPQMWEFCINEMGLEKGKTHLMNRYIAEGDMSVIMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW14</accession>
    <name>A0A401PW14_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010235">
        <property type="protein sequence ID" value="GCB77298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW14"/>
    <dbReference type="STRING" id="75743.A0A401PW14"/>
    <dbReference type="OMA" id="YEAGSHR"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8997" checksum="006D58DE3BE5FDDD" modified="2019-05-08" version="1">MLLVGTKKDLRNDPETIKKLKEQSLAPITQHQGNGLAKQIQAVKYMECSALNQEGIKEVFAEAVGAVINPTPVKIRKPCVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWE9</accession>
    <name>A0A401PWE9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0018474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012896">
        <property type="protein sequence ID" value="GCB77449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWE9"/>
    <dbReference type="STRING" id="75743.A0A401PWE9"/>
    <dbReference type="OMA" id="FIQGRQN"/>
    <dbReference type="OrthoDB" id="10051322at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22901">
        <property type="entry name" value="CcO_VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB77449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8309" checksum="2CCB61C7F9F7E5AB" modified="2019-05-08" version="1">MSSVIAKPAMRGLLAKLLRFHLAVAFTLSIACAGAFKVAVGDSRKKAYADVYKKYDAIKSFEAMRDAGIFEMSKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWM6</accession>
    <name>A0A401PWM6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Link domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0019292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014203">
        <property type="protein sequence ID" value="GCB77526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWM6"/>
    <dbReference type="STRING" id="75743.A0A401PWM6"/>
    <dbReference type="OMA" id="NGVRICC"/>
    <dbReference type="OrthoDB" id="9938473at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043210">
        <property type="entry name" value="CD44_antigen-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10225">
        <property type="entry name" value="HYALURONAN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10225:SF2">
        <property type="entry name" value="LYMPHATIC VESSEL ENDOTHELIAL HYALURONIC ACID RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018966469" description="Link domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="11">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB77526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="143" mass="16191" checksum="5E03738479363303" modified="2019-05-08" version="1">MKEWGVLTLIALSQTFLVLTQTSIDINDIEFSNCRILGVFHISLEDEYKLSQAQARNVCTSLGTLLATRFQVELAQRQGFETCRYGWVDDGFIVIPRISSKEQCGKNTIGVLNWNVDADKQYDGYCFRQNGVRICCPSMVVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXL1</accession>
    <name>A0A401PXL1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-methylacyl-CoA racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012981">
        <property type="protein sequence ID" value="GCB77838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXL1"/>
    <dbReference type="STRING" id="75743.A0A401PXL1"/>
    <dbReference type="OMA" id="MWTMKST"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008111">
        <property type="term" value="F:alpha-methylacyl-CoA racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008206">
        <property type="term" value="P:bile acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19735" checksum="A0143543757BA1B0" modified="2019-05-08" version="1">MALAGIRVIELAGLAPSPLCGMILADFGAKVVRIDRTRAFTADVLGRGKRSVALNIKKPEGAEVLKQLCNRSDVLIEPFRRGVMEKLGLGPEGMLEQNPKLIYARLSGFGQSGQYSKNAGHDINYIALSGLLSKFGRKGENPYAPLNVVADFAGGGLMCAMGIILALYERIKSGKGQVIDANMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYC1</accession>
    <name>A0A401PYC1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">High mobility group nucleosome-binding domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0015767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009109">
        <property type="protein sequence ID" value="GCB78122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYC1"/>
    <dbReference type="STRING" id="75743.A0A401PYC1"/>
    <dbReference type="OMA" id="WAEGVAK"/>
    <dbReference type="OrthoDB" id="9949982at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000079">
        <property type="entry name" value="HMGN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087:SF13">
        <property type="entry name" value="NON-HISTONE CHROMOSOMAL PROTEIN HMG-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087">
        <property type="entry name" value="NONHISTONE CHROMOSOMAL PROTEIN HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01101">
        <property type="entry name" value="HMG14_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00925">
        <property type="entry name" value="NONHISHMG17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00527">
        <property type="entry name" value="HMG17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB78122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13610" checksum="CE07A7FBFA707813" modified="2019-05-08" version="1">MSSKRKLIGEQREEPKRRSPRLSAKPTVPKAEPKEKNAPAKKEKVANDKKEEKKAPAKGKKGAKGKEEPNQEDAKEETPSENGEAKNDEAQSTESCDEKEAKSESLHLPVISINGIRTSILYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYS6</accession>
    <name>A0A401PYS6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase RNF10</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING finger protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0015806</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01009142">
        <property type="protein sequence ID" value="GCB78309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYS6"/>
    <dbReference type="STRING" id="75743.A0A401PYS6"/>
    <dbReference type="OMA" id="QELWPTI"/>
    <dbReference type="OrthoDB" id="10064108at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031643">
        <property type="term" value="P:positive regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000112">
        <property type="entry name" value="RING finger protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="706"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB78309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="785" mass="87908" checksum="6F4A3020DC57837B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZC8</accession>
    <name>A0A401PZC8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018372">
        <property type="protein sequence ID" value="GCB78482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZC8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8068" checksum="77C0890DE5719D44" modified="2019-05-08" version="1">MACLLRRLGLVRPGISINSGPCQNYIEVLTVGLKTYERPPCYDDAVMEFEPNRCLQSISLSLRILKPVINGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZU3</accession>
    <name>A0A401PZU3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01011821">
        <property type="protein sequence ID" value="GCB78641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZU3"/>
    <dbReference type="STRING" id="75743.A0A401PZU3"/>
    <dbReference type="OMA" id="KRFGVMF"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB78641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="211" mass="23549" checksum="DBBF5148195C877B" modified="2019-05-08" version="1">MFGKVRGGGVAALSAASERERERALQAATPGCNIGVLGCPGSGKSALTVKFLTKRFISEYDPYLEDTYNTEETVDHQSVLLKIMDTADQDKPANSERYLTWANAFIVVYSIDNRKSFEGCLHYLNAISTHAKGLPHDYPIILLGNKLDMERYRQVSKSDGLSLASKYNCSFYEVSASLDFEKRNAQRLNKLAHTMLSAIFYLSGYEISFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0A7</accession>
    <name>A0A401Q0A7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013193">
        <property type="protein sequence ID" value="GCB78798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0A7"/>
    <dbReference type="OrthoDB" id="9941526at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="177" mass="19986" checksum="D3C34CF62AF9992C" modified="2019-05-08" version="1">MKQRAIKAELQLLKMQYWMCQQHCWRVYNMAVEERSLRDLGLPFLEVGTEYGAAVSSALQELKTNYQSARQKVMEGLSLDSLPLLSVELKGLSCAAFVPAMLGEQQPMSQCQNNSNYRDRIAEQEVPSQETAAKKLVGAKEEADVLSDEPQTDHYQHVGHKVEAKNDCENIVKRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0X5</accession>
    <name>A0A401Q0X5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011887">
        <property type="protein sequence ID" value="GCB78943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0X5"/>
    <dbReference type="STRING" id="75743.A0A401Q0X5"/>
    <dbReference type="OMA" id="KEMDKFC"/>
    <dbReference type="OrthoDB" id="6054650at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061501">
        <property type="term" value="F:2',3'-cyclic GMP-AMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071360">
        <property type="term" value="P:cellular response to exogenous dsRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038001">
        <property type="term" value="P:paracrine signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000007">
        <property type="entry name" value="Cyclic GMP-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF35">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="3">
        <location>
            <begin position="119"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="235" mass="27154" checksum="36F370646B395580" modified="2019-05-08" version="1" fragment="single">KVERKKPGSPAVTLQIEDKELGPISLDMVLALEVHSQSWPNRTTDGLKIENWLGRKVRRNFRMEPFYLVPKQPLDVTQGAQSQSHKVMWRISFSHIEKKMLLNHGNLKTCCENGSSKCCRKPCLKLLKNLIQKLKAKNPRILASVCSYHAKTTLLHACAKRPKDETWSFENLDICFLQLLDDFVEYLQATNLPHFFIPTYNLFQPGLFDSRCREVLLRQIETQRNNGFLIFSGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5A8</accession>
    <name>A0A401Q5A8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011011">
        <property type="protein sequence ID" value="GCB80560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5A8"/>
    <dbReference type="STRING" id="75743.A0A401Q5A8"/>
    <dbReference type="OMA" id="RDCPDWL"/>
    <dbReference type="OrthoDB" id="284322at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04752">
        <property type="entry name" value="Commd4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037356">
        <property type="entry name" value="COMMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="138"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="207" mass="22892" checksum="11EE201929CF996C" modified="2019-05-08" version="1" fragment="single">VEVQPGVTMRFRFCGDLDCPDWVLAEISTLAKISSVKMKLLCVQVMKELLGDGIDYEKIAKLTADAKFETSDIKATIAVLNFVLASAGKYGVDGESLSSELQQLGLPKEHATALCKSYEEKQTALQDRLKESSLRLNKLDSVSWRVDYTLSSSELKEVNEPVVHLKINVRNVDTGDVEPMVVSVTANKFRVLLAELKQAQTLMNALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5U1</accession>
    <name>A0A401Q5U1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0016356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01009841">
        <property type="protein sequence ID" value="GCB80717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5U1"/>
    <dbReference type="STRING" id="75743.A0A401Q5U1"/>
    <dbReference type="OMA" id="TRNSENP"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB80717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="230" mass="27535" checksum="5FE93BBC6D2E0C5F" modified="2019-05-08" version="1">MDGDLQTEECELSYSVVPWLEFTSKESKTDDRPSPRLFVTHLPYQLIPKALKNKKAKVIYVYRNPKDVAVSYYHFHKFANYLETPENFGAFLQTFLNGQVDYDSWFNHVWNWYNHRHEFNIMFQSYEEMIKDLRVAVLKFSNFLGRSLDNKRVDTIVERSTFKNMKSNPKSNYENVGFPIFNNSVARFMRKGTVGDWKHHFTVAENEMFDRIFEEEMKNVPLKYTWEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8G2</accession>
    <name>A0A401Q8G2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022958">
        <property type="protein sequence ID" value="GCB81672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8G2"/>
    <dbReference type="STRING" id="75743.A0A401Q8G2"/>
    <dbReference type="OMA" id="RDPNHNN"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="290" mass="32062" checksum="999F6D79E7A3E231" modified="2019-05-08" version="1" fragment="single">ALVLMLVGQLGSCAPLGNFCSGREVGVYEDPNDVASFYQCMGNVTIYTTTLHTTVTVSGNISFCTWTPDGFHEDPQDNTNPNNNNGDPNNNTGDNNNNNRDPNNNTGDNNNNNRDPNHNNNTGDNNNNNNRDPNHNNGDNNNNNGDPNHNNGDNNNNNGDPNNNNNRDPNHNNGDNNNNGDPNNNNGDNNNRDPNHNNNNNNRDPNHNNNNNNRDPNHNNGDNNNNNTGDNNNNGDPNHNNGDNNNNNGDPNNNNNGDPNNNKDDPFQNKGNHYSDKDINNRFFNNRHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9X4</accession>
    <name>A0A401Q9X4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0021543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019316">
        <property type="protein sequence ID" value="GCB82166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9X4"/>
    <dbReference type="STRING" id="75743.A0A401Q9X4"/>
    <dbReference type="OMA" id="ECELASN"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="26"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB82166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="236" mass="26390" checksum="558AA8AB930A7F72" modified="2019-05-08" version="1">MPTFDDVLEEVGGFGVYQKLILFLVCLSSAAFAYLYVGFVFLAVTPDHWCQSPGVSELRENCSWSLEQEKNYTLPLGRSGSSSYSQCERYDVDWNSSSGSCENPLQFVQNGARDLPLTTCQDGWVFENGSPSSIVTEFELVCADAWKLDLTQACLNFGFTLGTIIMGYAADRFGRKSSFLFATFVTSVLGLVVSFLPNYNWFLIFRTLQGLFSKGSWLCAYVFGKNYAPTSCYNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QA93</accession>
    <name>A0A401QA93_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0023071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025977">
        <property type="protein sequence ID" value="GCB82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QA93"/>
    <dbReference type="STRING" id="75743.A0A401QA93"/>
    <dbReference type="OMA" id="CTEVEMG"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="57" mass="6479" checksum="C2EDED9382982CBD" modified="2019-05-08" version="1" fragment="single">CCTEVEMGRRKSKRKPPTKKKVLGTLETQFTCPFCNHEKSCDVKMDRARNTGVISCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAI0</accession>
    <name>A0A401QAI0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024739">
        <property type="protein sequence ID" value="GCB82398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAI0"/>
    <dbReference type="OrthoDB" id="8949674at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026728">
        <property type="entry name" value="BLTP3A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774:SF17">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24917">
        <property type="entry name" value="BLTP3A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="8048" checksum="2910D63735151650" modified="2019-05-08" version="1" fragment="single">VSTADQRRDSPKAMICCNKKSLYLPTEMAAIHIEFTEYYFPDGKDFPTLWNVLGRLDKNQHQSSVLDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD71</accession>
    <name>A0A401QD71_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01035979">
        <property type="protein sequence ID" value="GCB83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD71"/>
    <dbReference type="STRING" id="75743.A0A401QD71"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053337">
        <property type="entry name" value="AT-2_adhesin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37001">
        <property type="entry name" value="PHOSPHORYN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37001:SF5">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="378" mass="44216" checksum="E5E6C0703FF3D8F6" modified="2019-05-08" version="1" fragment="single">MHLTYFTQLLICFTHVPVYFSDPDRLHSNPDLLQSDPDLLQSDPDLRHCDPDMRHNDLNLLHNYPYLLHTDPDLRHCDPDMRHKDPDLRHSDPDLLHSDPDLRHSDPDLLHSDPDLLHSDPDLRHSDPDLLHNDPDLLHSDPDLLHSDPDLLHNDPDLLHNDPDLLHSDPDLLHSDPDLRHNDPDLRHSDPDLLHNDPDLWHNDPDLRYSDPDLLHNYPNLRHNDPDLRHSDPDLLHNYPNLLHSDPDLRHSDPDLRRSDPDLRHSDPDLLHCDPDLLHNDPDLLRSDPDLRHCDPDMRHKDPDLLHSDPDLRHSDPDLLHSDPDLLYCDPDMRHKDRDLLHSDPDLLHSDPDLRHSDPDLLHSDPDLLHCDPDLRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDN4</accession>
    <name>A0A401QDN4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01039974">
        <property type="protein sequence ID" value="GCB83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDN4"/>
    <dbReference type="STRING" id="75743.A0A401QDN4"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8270" checksum="F273FD3005E1CD1E" modified="2019-05-08" version="1" fragment="single">MESQSADAEPPPPPKPELHRYSGLRAHLSLATNEESNLLDRMDNPPTPTMYRYRPVYGSPGRNHTALTHSASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFB7</accession>
    <name>A0A401QFB7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01048987">
        <property type="protein sequence ID" value="GCB84007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFB7"/>
    <dbReference type="STRING" id="75743.A0A401QFB7"/>
    <dbReference type="OMA" id="ADWWDEE"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051493">
        <property type="entry name" value="CHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7617" checksum="A593660979C48F8C" modified="2019-05-08" version="1">MEVPADWWDEEADKSLLIGVFKHGYEKYNTMRADPALCFLEQVGRPDEKAIAAEQRGTDNFGDIGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFH4</accession>
    <name>A0A401QFH4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01055899">
        <property type="protein sequence ID" value="GCB84129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFH4"/>
    <dbReference type="OMA" id="MPTMSTM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="18369" checksum="6B50C496A57F1257" modified="2019-05-08" version="1">MTVLTVLTVLTVLDVLTVLTVMTVLTVLTVLTVPTVPTVLTVLTVPTVPTVLTVPTVPTVLTVLTVPTVLTVLTVLTILTVLTVLTVLTVLTVLTVLSVLTVLAVLTVLTVLTVLTVLTVLTVLTVLTVLTVLSVLTVLTVLTVLSVLTVLTELTVLTVLAVLTVDCTDCTDCVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFN1</accession>
    <name>A0A401QFN1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01053477">
        <property type="protein sequence ID" value="GCB84176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFN1"/>
    <dbReference type="STRING" id="75743.A0A401QFN1"/>
    <dbReference type="OMA" id="CWANIWL"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="18701" checksum="AD51EE5B1CED07B4" modified="2019-05-08" version="1">MRNISKSHCWANIWLTLCSDTLQDFLSQRLTEMKEEADILSINQFQTAPAIVQSQDEAKVVTMMSVVRDLVQRLTNVKMRHLFMIHASPRYIDRVTELLQQKLRQAEAVGEKQHLMVQKRQQSLEEQAALEPKLDLLVQRTKELRKLASYLFWCMCGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHT1</accession>
    <name>A0A401QHT1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01114874">
        <property type="protein sequence ID" value="GCB84934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHT1"/>
    <dbReference type="STRING" id="75743.A0A401QHT1"/>
    <dbReference type="OMA" id="GACPKIQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF5">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="379" mass="43984" checksum="CE956AFBB59D3281" modified="2019-05-08" version="1" fragment="single">MSSLESSLVSSLMSRLMSSLSRVQSRVQSHVQSRVQSHVQPRVQSRVQSRVQSRVQPRVQSRVQPRVQSRVQSHVQSRVQSRVQSRVQPRVQSRVQSRVQSRVQSHVQSRVQSRVQSHVQSRVQPSVQYGVQTRVQTRVQIRVQSRVQSCVQSQVQSRVQSRVQSRVQSRVQSRVQSRVQSRVHTRVQSRVQSRVQSRVQSRVQSRVHTRVQARVQSHVQSRVQSRVQSRVHTRVQSRVQSRVQSCVQARVQSHVQSHVQSRVQTRVQSRVQSRVQSHVQSRVQSRVQSRVQSRVQSRVQSRVQSRVQSRVQYGVQPHVQSHVQSRVQSRGQTRVQTRVQIRVQSRVQSCVQSHVQSRVQSRVQSRVQSRVQSRVQSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK35</accession>
    <name>A0A401QK35_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01195944">
        <property type="protein sequence ID" value="GCB85761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK35"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9287" checksum="D55829AD0E69B395" modified="2019-05-08" version="1">MRDKPYQLESNLEDNQARDCSTVCATQLPFKEDQIDACVDNAKFMHNGTNVRKNRTLFGKKRHSNGLEMVVLAEKPDINTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK90</accession>
    <name>A0A401QK90_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01202155">
        <property type="protein sequence ID" value="GCB85831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK90"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="120" mass="13176" checksum="2ADCA1FCE088854D" modified="2019-05-08" version="1">MLDIIARDIVVLDIIVLDIVLLDIIALDIVVLDIVTLDISVLEFIDLSMITWDIIALDIVALDITALDIGVLDIILLDFVVLGIKALDIVVLDISILEDHIDLSMVKTGYYSTGYCSTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNL7</accession>
    <name>A0A401QNL7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01383558">
        <property type="protein sequence ID" value="GCB87007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNL7"/>
    <dbReference type="STRING" id="75743.A0A401QNL7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="16971" checksum="2E153B7E8F8231D0" modified="2019-05-08" version="1">MECSVEYCVDYSVELECSIEYCVEYSEEYSVECSREYSEEYSIECCVEYSMKYFVEYCMECSMEYSEEYSMVFSVEYSVDYSIECSVEYSIEYRVEFSMECSVEYCVEYSVEYSMECSREYSEEYSIECCVEYSMKYFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPI5</accession>
    <name>A0A401QPI5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0028006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01449888">
        <property type="protein sequence ID" value="GCB87311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPI5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="66" mass="7454" checksum="04D79FCB00F8F472" modified="2019-05-08" version="1" fragment="single">KEREESGEDTVKERKQKCRDTVKEREESGGETVKELEQSGGDTVKEREQSGRDTAKEREEIGGGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPR8</accession>
    <name>A0A401QPR8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0028016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01452576">
        <property type="protein sequence ID" value="GCB87322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPR8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="51" mass="6063" checksum="00EDA0FC7BD39C03" modified="2019-05-08" version="1" fragment="single">RERERQNASARDRMQARLTEREGERQNASAIDRTSSARDRTRARDTECKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A223AB74</accession>
    <name>A0A223AB74_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HoxB9</name>
        <name evidence="15" type="ORF">scyTo_0000711</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-06" db="EMBL/GenBank/DDBJ databases">
            <title>Lethenteron camtschaticum and Scyliorhinus torazame Hox genes.</title>
            <authorList>
                <person name="Pascual-Anaya J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="MF398255">
        <property type="protein sequence ID" value="ASS31211.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAA01000145">
        <property type="protein sequence ID" value="GCB67351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A223AB74"/>
    <dbReference type="STRING" id="75743.A0A223AB74"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000018">
        <property type="entry name" value="Homeobox A10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006711">
        <property type="entry name" value="Hox9_activation_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017112">
        <property type="entry name" value="HXA9/HXB9/HXC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45970">
        <property type="entry name" value="AGAP004664-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45970:SF5">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04617">
        <property type="entry name" value="Hox9_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037109">
        <property type="entry name" value="Homeobox_Hox9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASS31211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB67351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="252" mass="28588" checksum="0C6726D9578A554B" modified="2017-10-25" version="1">MSISGAISNYFVDSLISHESEGSPATKFASGQYIVSRQPGVPEHPEFPACNFQPKSPVFGASWAPVYAQSSGNVSTLYHPYVQSHPIQPDSRYMRSWLDPTARAVSLPGMPSSRHDSLKTEVLAGPGGEPLPTALQKVHGEYLESEPIISGKAPCYEDSICGEKADKEASEQNNPSANWLHARSTRKKRCPYSKYQTLELEKEFLFNMYLTRDRRHEVARLLNLTERQVKIWFQNRRMKMKRLSKEHVKEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NFN9</accession>
    <name>A0A401NFN9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0012585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006109">
        <property type="protein sequence ID" value="GCB59769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NFN9"/>
    <dbReference type="STRING" id="75743.A0A401NFN9"/>
    <dbReference type="OMA" id="RRANNYE"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF43">
        <property type="entry name" value="HOMEODOMAIN-INTERACTING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB59769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="87445" checksum="429EEBC306766926" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGN8</accession>
    <name>A0A401NGN8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0014061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007410">
        <property type="protein sequence ID" value="GCB59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGN8"/>
    <dbReference type="STRING" id="75743.A0A401NGN8"/>
    <dbReference type="OMA" id="HVCSFVW"/>
    <dbReference type="OrthoDB" id="9925579at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047143">
        <property type="entry name" value="GPER1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24226:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 146-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24226">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="46"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="346" mass="38682" checksum="88275D5A8523ED28" modified="2019-05-08" version="1">MWSCIQGNFGPNSTFCGDDLCHNVGLILSIASTAYLIVCFPLGLIFNVLVLVVNLRHKLSINMSDVYFTNMALAGLILNLVAFLQLLGPDHLLWPVWTFGRELCMVSFILFNMAALVSIYSATLLSLDCFIEQALPHTYMSSVYNTKHVCSFVWGGAALASFSSLLFYVCSKISEEVNDCSKLQTKELGDAIMFFTGLVVPTAGVGYAFRLILCPRKSHLFQLAESSRLDPSIQRLLLPTVLAQFALWLPYYLTLLVSTAHFVTRARDDMRFANLLHFLRGGCELLAYVSTCAVPMIYKCLQKTFDSRLRLVIQDMQCGLKWGLCNQRGLRQQHIATVSQAELPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHC0</accession>
    <name>A0A401NHC0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Heparanase</fullName>
            <ecNumber evidence="10">3.2.1.166</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>endohydrolysis of (1-&gt;4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan.</text>
            <dbReference type="EC" id="3.2.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.166" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01004935">
        <property type="protein sequence ID" value="GCB60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHC0"/>
    <dbReference type="STRING" id="75743.A0A401NHC0"/>
    <dbReference type="OMA" id="CTPFTKN"/>
    <dbReference type="OrthoDB" id="726732at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060055">
        <property type="term" value="P:angiogenesis involved in wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000024">
        <property type="entry name" value="Heparanase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46145">
        <property type="entry name" value="HEPARANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46145:SF3">
        <property type="entry name" value="HEPARANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="421" mass="47084" checksum="436B34F758C5B2A9" modified="2019-05-08" version="1" fragment="single">DCLNTIPFNVEKYLTYLLALQAPVVLKEEFQKDFKNITISERSVDILHSFANCSGLHLIFGLNALLRKHHAWDSSNAQKLLRYCASRQYNMSWELGNEPNSFRKKAHIKIRGTQLGEDFDHLYSLLHTFRTFNHTGLYGPDIGQPGRRATIALLKGFLKTGGKVLDAITWHHYYVNGRNASLKDFLSPQVLDSLVLKINQIFEVASKIAPDKKVWLGETSSAFGGGAPDLSDKYVAGFMWLDKLGLSAKLGIDVVIRQALFGAGFYQLVDRMLDPLPDYWLSFIYKKLVGAKVLNVSAVHGDAANNGTLRVYMHCTNPHSQIYQKGSVTMFVLNLSDQDKHVLLCCSVFNKTVQFLLQPGDSEEGLYSQSVQLNGELLKMVDRKTMPIIKGKALQPGSPIILPAHSYAFYVVQDAKAPACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIK3</accession>
    <name>A0A401NIK3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Purinergic receptor P2X 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0003984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the P2X receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001136">
        <property type="protein sequence ID" value="GCB60693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIK3"/>
    <dbReference type="STRING" id="75743.A0A401NIK3"/>
    <dbReference type="OMA" id="RIWDATD"/>
    <dbReference type="OrthoDB" id="494673at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004931">
        <property type="term" value="F:extracellularly ATP-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001614">
        <property type="term" value="F:purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.940">
        <property type="entry name" value="atp-gated p2x4 ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.490.10">
        <property type="entry name" value="atp-gated p2x4 ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003047">
        <property type="entry name" value="P2X4_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027309">
        <property type="entry name" value="P2X_extracellular_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059116">
        <property type="entry name" value="P2X_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125">
        <property type="entry name" value="P2X PURINOCEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125:SF18">
        <property type="entry name" value="P2X PURINOCEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00864">
        <property type="entry name" value="P2X_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01311">
        <property type="entry name" value="P2X4RECEPTOR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14667" checksum="1183D86F5BD211A5" modified="2019-05-08" version="1">MAGCCSSVSDFLLEYDTPRIVLIKNRKVGAINRVVQVIILAYVIGWVLVWEKGYQEFDSTIGTVTSKVKGIAITNSTAFEERIWDATDYVIPSQQENSFFVMTNVILTMNQVQGRCPERPAQNYYPGDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIU4</accession>
    <name>A0A401NIU4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Winged helix Storkhead-box1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0006931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002424">
        <property type="protein sequence ID" value="GCB60783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIU4"/>
    <dbReference type="STRING" id="75743.A0A401NIU4"/>
    <dbReference type="OMA" id="KECKDSY"/>
    <dbReference type="OrthoDB" id="10020110at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019391">
        <property type="entry name" value="Storkhead-box_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040126">
        <property type="entry name" value="STOX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437:SF2">
        <property type="entry name" value="STORKHEAD-BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437">
        <property type="entry name" value="WINGED HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10264">
        <property type="entry name" value="WHD_Storkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix Storkhead-box1" evidence="2">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB60783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="856" mass="96399" checksum="CA1C11FDFB4840C4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ62</accession>
    <name>A0A401NJ62_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Potassium voltage-gated channel subfamily A member 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Voltage-gated potassium channel subunit Kv1.4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0012818</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006319">
        <property type="protein sequence ID" value="GCB60910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ62"/>
    <dbReference type="STRING" id="75743.A0A401NJ62"/>
    <dbReference type="OMA" id="EPDHGFT"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000012">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000021">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.600">
        <property type="entry name" value="Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012897">
        <property type="entry name" value="K_chnl_volt-dep_Kv1.4_TID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037065">
        <property type="entry name" value="K_chnl_volt-dep_Kv1.4_TID_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF284">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07941">
        <property type="entry name" value="K_channel_TID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="20">
        <location>
            <begin position="113"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB60910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="562" mass="62719" checksum="E14CF1C0746F050D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM17</accession>
    <name>A0A401NM17_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001213">
        <property type="protein sequence ID" value="GCB61889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM17"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8158" checksum="6198E293EFB50EC0" modified="2019-05-08" version="1">MPSSGRLFLSPDLQIRLEWTFLSGIVASILNVYYVEATHPGLADVSFDLSRCEPTLDLCVLVMTFSCKESAMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMT4</accession>
    <name>A0A401NMT4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0014452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007762">
        <property type="protein sequence ID" value="GCB62180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMT4"/>
    <dbReference type="STRING" id="75743.A0A401NMT4"/>
    <dbReference type="OMA" id="ICGGVWL"/>
    <dbReference type="OrthoDB" id="9881476at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001621">
        <property type="term" value="F:G protein-coupled ADP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045029">
        <property type="term" value="F:G protein-coupled UDP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045030">
        <property type="term" value="F:G protein-coupled UTP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905835">
        <property type="term" value="P:cellular response to pyrimidine ribonucleotide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000017">
        <property type="entry name" value="lysophosphatidic acid receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000371">
        <property type="entry name" value="P2Y3_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF16">
        <property type="entry name" value="P2Y PURINOCEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01065">
        <property type="entry name" value="P2Y3PRNOCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="88"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="378" mass="43042" checksum="18E1969591408A35" modified="2019-05-08" version="1">MQERSIIPELEYSSLSLPVCVVLANLILDGEGLNEKNRPKHSGDGNMNNSTSDLQPSLQTRGCTYQEKFKNILLPVTYTVVLVFGLTLNMTVIVQLWFSQKPLTRSAIYMVNLAMADVLYVCSLPLLIYNYIHMDYWPFGEIMCKAVRFLFYANLHGSILFLTCISLQRYLGICHPLSTWHKKQGPRFAWMVCGLLWTFVIAECAPTWRFASTGVQRNRTVCYDLSSPENSLYYFPYGITLTVVGFMIPFIGLLACYCAMAMALHKPDKVLGLTNERKKSKALRMIIIVTVVFVISFVPFHVTKTAYLIIRARSSVACQTLQSFARAYKATRPLASLNSVLDPILFYFTYEGFRQSTRNLLEKVSTNRQARAQKVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN32</accession>
    <name>A0A401NN32_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001239">
        <property type="protein sequence ID" value="GCB62301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN32"/>
    <dbReference type="STRING" id="75743.A0A401NN32"/>
    <dbReference type="OMA" id="TELSCWV"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110064">
        <property type="term" value="P:lncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032785">
        <property type="term" value="P:negative regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140744">
        <property type="term" value="P:negative regulation of lncRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071027">
        <property type="term" value="P:nuclear RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000065">
        <property type="entry name" value="WD repeat-containing protein 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB62301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="313" mass="35181" checksum="31CBCCD3F1E28691" modified="2019-05-08" version="1">MKLTDNVLRSFRVAKVFRENTDKINCFDFSPNGETLISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFHGHSKRVVALCMSPVDDTFMSSSLDKTIRLWDLRSPNCQGLMHLQGRPTCSFDPEGLIFAAGVNSEIIKLYDLRSFDKGPFATFKMQYERTCEWTGLKFSNDGKLMLVSTNGGMVRLIDAFKGAVLQTFGGYNNNKGISLEASFTPDSQFVMIGSEDGKVHVWNAESGLKVAVLDGKHTGPVSCLQFNPKFMTFASACSNMAFWLPTIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN92</accession>
    <name>A0A401NN92_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0007218</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002569">
        <property type="protein sequence ID" value="GCB62346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN92"/>
    <dbReference type="STRING" id="75743.A0A401NN92"/>
    <dbReference type="OMA" id="QECCKIA"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000209">
        <property type="entry name" value="sterol regulatory element-binding protein cleavage-activating protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000391">
        <property type="entry name" value="sterol regulatory element-binding protein cleavage-activating protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057042">
        <property type="entry name" value="Beta-prop_SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24017">
        <property type="entry name" value="Beta-prop_SCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 21" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="24">
        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="914"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="955"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB62346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119466" checksum="C94C1A7277BD74EB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NR33</accession>
    <name>A0A401NR33_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc transporter ZIP4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 39 member 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zrt- and Irt-like protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0011600</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005330">
        <property type="protein sequence ID" value="GCB63309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NR33"/>
    <dbReference type="STRING" id="75743.A0A401NR33"/>
    <dbReference type="OMA" id="PPKQPHE"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049406">
        <property type="entry name" value="ZIP4_12_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041137">
        <property type="entry name" value="ZIP4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF21">
        <property type="entry name" value="ZINC TRANSPORTER ZIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21116">
        <property type="entry name" value="EF-hand_Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18292">
        <property type="entry name" value="ZIP4_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 23" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0864">Zinc transport</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019249150" description="Zinc transporter ZIP4" evidence="23">
        <location>
            <begin position="21"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc transporter ZIP4 N-terminal" evidence="24">
        <location>
            <begin position="55"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc transporter ZIP4/12 EF-hand" evidence="25">
        <location>
            <begin position="220"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF21116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB63309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="879" mass="96373" checksum="F393455D6CB12E13" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NR51</accession>
    <name>A0A401NR51_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">scyTo_0007378</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002659">
        <property type="protein sequence ID" value="GCB63356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NR51"/>
    <dbReference type="OMA" id="RPLIRWY"/>
    <dbReference type="OrthoDB" id="5979328at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005021">
        <property type="term" value="F:vascular endothelial growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002412">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000041">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000143">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
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    <dbReference type="InterPro" id="IPR041348">
        <property type="entry name" value="VEGFR-2_TMD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055229">
        <property type="entry name" value="VEGFR1-3_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055238">
        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009135">
        <property type="entry name" value="VEGFR1_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22971">
        <property type="entry name" value="Ig_VEGFR-1-like_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21339">
        <property type="entry name" value="VEGFR-1-like_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17988">
        <property type="entry name" value="VEGFR-2_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22854">
        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01832">
        <property type="entry name" value="VEGFRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01833">
        <property type="entry name" value="VEGFRECEPTR1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="12 22 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 22 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 26" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018999296" description="receptor protein-tyrosine kinase" evidence="26">
        <location>
            <begin position="28"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="227"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="389"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="515"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="616"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="787"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="921"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="794"/>
            <end position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22 24">
        <location>
            <position position="821"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="988"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="989"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="1002"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="GCB63356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1304" mass="146715" checksum="ED23D996474AF463" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRK5</accession>
    <name>A0A401NRK5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000026">
        <property type="protein sequence ID" value="GCB63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRK5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="171" mass="18861" checksum="42044F34DBFA7A41" modified="2019-05-08" version="1">MGTVVGRVSFRMGRGECFVRQFGTGKVGLGDILGVSDSTVELMVQADQRARRLVDSVQKNRGLGPIGLGKVVREGLETTELAFCRICESGVDRTGERTRVLSEQSERVVRVGLQRYEEAFCRAWVMVRGRLVRPEGEGLLDLTEGWLLVATANLCPLRRFGSSGRKGRCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS05</accession>
    <name>A0A401NS05_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C-mannosyltransferase DPY19L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0014665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007956">
        <property type="protein sequence ID" value="GCB63681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS05"/>
    <dbReference type="STRING" id="75743.A0A401NS05"/>
    <dbReference type="OMA" id="YDNITEY"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF1">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="78409" checksum="C65CD7E6774FCAEB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSP2</accession>
    <name>A0A401NSP2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase epsilon subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. Interaction with POLE3 is a prerequisite for further binding with POLE and POLE2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001337">
        <property type="protein sequence ID" value="GCB63896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSP2"/>
    <dbReference type="STRING" id="75743.A0A401NSP2"/>
    <dbReference type="OMA" id="CYAFLEG"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000051">
        <property type="entry name" value="DNA polymerase epsilon 4, accessory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF79">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="119" mass="12833" checksum="9F3323F3D1F92C55" modified="2019-05-08" version="1">MEELESGVAVAEPGQSLQLEAEAEAERPGSAPLPGLHHKLLRLPLSRIKGLMKADPDVSLASQEAVFAIGKATELFVEVIAKDAYTFALQGKRKTIQRKDVDNAVDATDEFAFLEGTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVA1</accession>
    <name>A0A401NVA1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0009865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004136">
        <property type="protein sequence ID" value="GCB64772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVA1"/>
    <dbReference type="STRING" id="75743.A0A401NVA1"/>
    <dbReference type="OMA" id="SINHECH"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000013">
        <property type="entry name" value="Amphiphysin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003017">
        <property type="entry name" value="Amphiphysin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF2">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01252">
        <property type="entry name" value="AMPHIPHYSIN1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="9">
        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB64772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="346" mass="39250" checksum="CA386AD4F0FC4D8B" modified="2019-05-08" version="1">MADNIKTGVFAKNVQKRLNRAQEKVLQKLGKADETRDEQFEGFVQNFKKQEAEGSRLQRELRGYLTAVKGMQEASTKLTESLHEVYEPEWYGRDDVKAVGQNSDLLWADFHQKLVDQALLTLDTYLGQFPDIKTRIAKRSRKLVDYDCARHHLESLQHSKRRDDSKLTKAEEEFQKAQKVFEELNTDLQDELPSLWTSRVGFYVNTFRNITCIESKFHKEIAVLCHKLYEIMSKLGEQHADKAFTIQGAPSDSGPLRISKTPTPPEEPSPPSSPVTSPNHTLAPLAASPAHTPTRPKSPSQLRRGPPVPPPPKLTPTKELHQENIINFFEDNFVPEISVTSPSQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVH3</accession>
    <name>A0A401NVH3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005502">
        <property type="protein sequence ID" value="GCB64857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVH3"/>
    <dbReference type="STRING" id="75743.A0A401NVH3"/>
    <dbReference type="OMA" id="IGHERRE"/>
    <dbReference type="OrthoDB" id="8938311at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="100" mass="10775" checksum="3141F8EB38B12B87" modified="2019-05-08" version="1">MSKGVVEKEIGHERRELEIRQHKGSIAPGVVLLTVEDPEIRVGSGGATLNALLVAAEHLSAKAGYTVVTSDVLQTARILILHMACSSLYIAILFKCLQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVQ1</accession>
    <name>A0A401NVQ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">IMP2-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0004690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001404">
        <property type="protein sequence ID" value="GCB64937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVQ1"/>
    <dbReference type="STRING" id="75743.A0A401NVQ1"/>
    <dbReference type="OMA" id="MHPTMTG"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000045">
        <property type="entry name" value="Inner mitochondrial membrane peptidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB64937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="13437" checksum="3532314A4E52B6EC" modified="2019-05-08" version="1">MELLAFRYWLQEARSPKDPEQKIIKRVIALEGDIIRTMGHRNRYIKIPNGHLWIEGDHHGHSFDSNVFGPVSLGLVHARASHIIWPPNRWMKLQTDLPEERRPLLSGSNDPADGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVZ2</accession>
    <name>A0A401NVZ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000067">
        <property type="protein sequence ID" value="GCB65004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVZ2"/>
    <dbReference type="STRING" id="75743.A0A401NVZ2"/>
    <dbReference type="OMA" id="CAIQHAT"/>
    <dbReference type="OrthoDB" id="2505895at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000011">
        <property type="entry name" value="unconventional myosin-XVIIIa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="545"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="591" mass="67789" checksum="54E37118EC40D4DD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX65</accession>
    <name>A0A401NX65_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0004791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001438">
        <property type="protein sequence ID" value="GCB65444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX65"/>
    <dbReference type="STRING" id="75743.A0A401NX65"/>
    <dbReference type="OMA" id="ANQMSEA"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="236" mass="26634" checksum="2082D0EE35FCBA40" modified="2019-05-08" version="1">MSTQLDADRDEEEVFYDISVTVDSKLFPTKDPVAENLKQTKIIFVIGGPGSGKGTQSRRVAEEYGFTHLSAQDILLNTMVVGSDRRKETQETVEHGELVPVKIKDAMMSSMDAKGILIDDYPWELKQAEEFEKKVARPSLVLFLSSSRATMKQRLLKSARKSDHATGDEELVTKQIEDHLSATQLIVEKYQRDNLIRKINAEEMPDKVFRQICEAIDSIQESSESDMASDGFLCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXR4</accession>
    <name>A0A401NXR4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0009986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004217">
        <property type="protein sequence ID" value="GCB65662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXR4"/>
    <dbReference type="STRING" id="75743.A0A401NXR4"/>
    <dbReference type="OMA" id="KFPRICA"/>
    <dbReference type="OrthoDB" id="74247at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="63"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB65662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="154" mass="17411" checksum="80BB91C20C86A63D" modified="2019-05-08" version="1">MWARSYHALPQGTPHPGFSRRGRFQAAMSLKAVANLLMVTFPKMSSYRSGASSAHTSADQTVTHDRTKQQFSVRLGDSREEAVLQYRYIGTKMIDLHSTSVPVTFRGKGVGGLLAQAALNFVVEEDLKMRISCWFVRKYVDDNPQPQYRERIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY69</accession>
    <name>A0A401NY69_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000091">
        <property type="protein sequence ID" value="GCB65790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY69"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="10127" checksum="231301945F49599F" modified="2019-05-08" version="1">MADMVAGGMADMVPGGIADMVAGGMADMVAGGMADMVAGGMADMVAGGIADMVAGGMADMVAGGMADMVAGGMADMVAGGMADVFNVTFQFSSCVFIIIDIRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P088</accession>
    <name>A0A401P088_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001507">
        <property type="protein sequence ID" value="GCB66520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P088"/>
    <dbReference type="STRING" id="75743.A0A401P088"/>
    <dbReference type="OrthoDB" id="9895813at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="13932" checksum="034624289970401D" modified="2019-05-08" version="1">MLIESCHLLKSKLWPQSRLLIKQLSSGRILNFNADRWLSRQHDDGEIVREFPLSRERDGKPFYPVVKYQVQIHTGRLEEPDSYLPIHICIYGERGDTGLRYLYKFDKPAKFKKGRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0A4</accession>
    <name>A0A401P0A4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HAUS augmin-like complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0012031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005682">
        <property type="protein sequence ID" value="GCB66592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0A4"/>
    <dbReference type="STRING" id="75743.A0A401P0A4"/>
    <dbReference type="OMA" id="LEWFCGN"/>
    <dbReference type="OrthoDB" id="2159690at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031023">
        <property type="term" value="P:microtubule organizing center organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026206">
        <property type="entry name" value="HAUS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032733">
        <property type="entry name" value="HAUS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19378">
        <property type="entry name" value="GOLGIN- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19378:SF0">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14932">
        <property type="entry name" value="HAUS-augmin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02089">
        <property type="entry name" value="HAUSAUGMINL3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="52"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB66592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="623" mass="72428" checksum="1B4970498FB5F565" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P174</accession>
    <name>A0A401P174_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sortilin-related receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Low-density lipoprotein receptor relative with 11 ligand-binding repeats</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Sorting protein-related receptor containing LDLR class A repeats</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">scyTo_0005041</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
            <location evidence="7">Multivesicular body membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">trans-Golgi network membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Recycling endosome membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the VPS10-related sortilin family. SORL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001530">
        <property type="protein sequence ID" value="GCB66860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P174"/>
    <dbReference type="OMA" id="XENEFIL"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000006">
        <property type="entry name" value="Putative low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000303">
        <property type="entry name" value="Sortilin related receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000027">
        <property type="entry name" value="Sortilin related receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000030">
        <property type="entry name" value="Sortilin related receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000002">
        <property type="entry name" value="Sortilin-related receptor isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000021">
        <property type="entry name" value="Sortilin-related receptor isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000002">
        <property type="entry name" value="Sortilin-related receptor isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000033">
        <property type="entry name" value="Sortilin-related receptor isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057841">
        <property type="entry name" value="FN3_SORL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
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        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="LDLRECEPTOR"/>
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    </dbReference>
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        <property type="match status" value="5"/>
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        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="LDLRA_2"/>
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        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="27" id="KW-0968">Cytoplasmic vesicle</keyword>
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    <keyword evidence="14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0254">Endocytosis</keyword>
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            <end position="2086"/>
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            <end position="774"/>
        </location>
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            <end position="818"/>
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            <end position="903"/>
        </location>
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            <end position="1576"/>
        </location>
    </feature>
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            <end position="1671"/>
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            <end position="1770"/>
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            <end position="1957"/>
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        <location>
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            <end position="1020"/>
        </location>
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        <location>
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            <end position="1033"/>
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    <feature type="disulfide bond" evidence="30">
        <location>
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        <location>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="30">
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            <end position="1141"/>
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    <feature type="disulfide bond" evidence="30">
        <location>
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            <end position="1325"/>
        </location>
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    <feature type="disulfide bond" evidence="30">
        <location>
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        </location>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00029896"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00032450"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="2139" mass="240655" checksum="9FB5C62F39123286" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1H7</accession>
    <name>A0A401P1H7_SCYTO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008359">
        <property type="protein sequence ID" value="GCB66964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6630782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="134" mass="15922" checksum="4E629012026F7958" modified="2019-05-08" version="1">MQRSREHPVPMQLSWEHPVPVQLSRERPVPMELSRENPVPMELSRDNPVPMQLSREHPVPMQLSWECPVPMQLSRMHPLPIQLSREHPVPMQLSWERPVPMQQSRDRPVPMQLSRERPVPMELFRERPVPMQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1L6</accession>
    <name>A0A401P1L6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UbiA prenyltransferase domain-containing protein 1</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0005066</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>menadiol + (2E,6E,10E)-geranylgeranyl diphosphate = menaquinol-4 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:74083"/>
            <dbReference type="ChEBI" id="CHEBI:6746"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:193091"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:74084"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01001542">
        <property type="protein sequence ID" value="GCB67016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1L6"/>
    <dbReference type="STRING" id="75743.A0A401P1L6"/>
    <dbReference type="OMA" id="IGNTHAK"/>
    <dbReference type="OrthoDB" id="203513at2759"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000005">
        <property type="entry name" value="UbiA prenyltransferase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB67016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="330" mass="35800" checksum="2D44C4679061393A" modified="2019-05-08" version="1">MSQNGGAKQMDVDAESRVHGPVADREAAPGLGRSLKHKCAAYVLALRPWSFSASLTPVALGTALAYKNLGELDLAISLLAALAVLAVHAAGNLVNTYCDFSRGIDHKKSDDRTLVDRILEPQDVVRFGACLYTLGCLCASSLYFLCKLKLEHLALIFFGGLSSSFLYTGGIGFKYFALGDIIILITFGPLAVMFAYSVQVGYLAVSPLLYAIPLALNTEAILHSNNTRDMESDKQAGIVTFAIIIGPTLSYIVYNMLIFIPYVIFCILATRYTISLALPLLTVPLAFSLERQFRSQNYAKIPQMTAKLNLLLGLFYVFAILLAPPGSLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2E8</accession>
    <name>A0A401P2E8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0012125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005756">
        <property type="protein sequence ID" value="GCB67292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2E8"/>
    <dbReference type="STRING" id="75743.A0A401P2E8"/>
    <dbReference type="OMA" id="NEDEWLF"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000008">
        <property type="entry name" value="Coatomer subunit zeta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF4">
        <property type="entry name" value="COATOMER SUBUNIT ZETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB67292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="169" mass="19350" checksum="71E08CE046346F13" modified="2019-05-08" version="1">MDPSALEPSLYTVKAIIILDNDGERLHAKYYDNAYPSTKEQRNFEKNIFSKTHKNDSEIAFLEGLTVIYKSSVDLYFYIVGNPQENELMLMTVLNCLFDSLSQMLRKNVEKKSLMENMDGVLLIMDEIVDGGTVISELHKYVDDTPLTEQSMAQVLQSAKDQIKWSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2Q9</accession>
    <name>A0A401P2Q9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0005119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001567">
        <property type="protein sequence ID" value="GCB67383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2Q9"/>
    <dbReference type="STRING" id="75743.A0A401P2Q9"/>
    <dbReference type="OMA" id="QKSCPLK"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000078">
        <property type="entry name" value="NK2 homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF32">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB67383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="319" mass="35431" checksum="96987FC2BA0C9F56" modified="2019-05-08" version="1">MMLPSPVTSTPFSVKDILNLEQQTRQQVARHLQQNAPAQFQPPPSCMHAAGEASSFSEGEEKIPFMNSLSVHDSQGDVSLSPELYVHAALRSPCETKLEEEILGDEDKKTCTLKKSPESDDNKGEGAERAKQRQRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLANTLKLTSTQVKIWFQNRRYKCKRQRQDKSLEIAGHHHPPPPRRVAVPVLVRDGKPCIAGSQSYSSPYTVGANAYAYNSYPASYGSYGGTSAYNANYSCTYTSIPTLQPSSAPNAFMNVDLSNVNSAMQTPSHQGAGVPACQGTLQGIRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3C0</accession>
    <name>A0A401P3C0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0013730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007130">
        <property type="protein sequence ID" value="GCB67639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3C0"/>
    <dbReference type="STRING" id="75743.A0A401P3C0"/>
    <dbReference type="OMA" id="CNDISSM"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000679">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000771">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001681">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="583"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB67639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="762" mass="85112" checksum="1FE90D8D1CB163F4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4E2</accession>
    <name>A0A401P4E2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 162 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0000802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000165">
        <property type="protein sequence ID" value="GCB68004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P4E2"/>
    <dbReference type="OMA" id="PDMTDNE"/>
    <dbReference type="OrthoDB" id="2157184at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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    <sequence length="397" mass="45767" checksum="7ADB85134922EEE2" modified="2019-05-08" version="1" fragment="single">QSVMNSLSRGKKAFGDLIPWTVSEQDPDFGSLSGGRIVRIAVHPDYQGAISLLEEMLSPRKDLPPLLLKLNERPTEKLDYLGVSYGLTSQLLKFWKRAGYAPVYLRQTPNELTGEHSCIMLKALNEEEEDVESPRENWLLAFWKDFRRRFLSLLSYQFNSFPPSVALNILQNKNMKQELKPRLNRSELETKFTPYDLKRLEMYSRNMVDYHLIMDMLPSISQLYFLNQLGDISLSVAQSALLLGVGLQHKSVDQLEKEIDLPSSQLMGLFNRLIRKVVQLFNNILEKAVEEQMITAKEIVMEPTIKSLSEDLEEAAKEFQAKHKEEVEKLKGMDLTQYMIRGNAEEWNDVLKTAGQNATIISIQGAKRKQDSVEKGSIQLQKKRMKKNKEKKQKWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P596</accession>
    <name>A0A401P596_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0012251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the synaptopodin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005863">
        <property type="protein sequence ID" value="GCB68250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008438">
        <property type="entry name" value="MYOZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051976">
        <property type="entry name" value="Synaptopodin_domain"/>
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    <dbReference type="PANTHER" id="PTHR24217">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217:SF13">
        <property type="entry name" value="SYNAPTOPODIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05556">
        <property type="entry name" value="Calsarcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
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        <location>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB68250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="802" mass="87285" checksum="ACCBC0E140E3E027" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5K9</accession>
    <name>A0A401P5K9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0013822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007216">
        <property type="protein sequence ID" value="GCB68412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5K9"/>
    <dbReference type="STRING" id="75743.A0A401P5K9"/>
    <dbReference type="OrthoDB" id="9990008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF80">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN LHX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="22155" checksum="54D637E7A16A000A" modified="2019-05-08" version="1" fragment="single">LSCNENDGDHMDREQQYPPTQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENAGVDKASDGTVLQAATPSGPASEISNASLSPSSTSTTLTDLTNPSMPTVTCFVQLTNSTMDLYRKLRQVNVLEKKVYKLRRTFAELTSMPFRVIVQFCGLNKGMKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P632</accession>
    <name>A0A401P632_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007235">
        <property type="protein sequence ID" value="GCB68585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P632"/>
    <dbReference type="STRING" id="75743.A0A401P632"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="152" mass="17576" checksum="41314811060D44BF" modified="2019-05-08" version="1">MKERRDKRSEGAKRQGSEGAKETRGVKERRDTRSDGAKRHAEGRSEETRGVKERRDTWSEGTRRQWSEGTKTQRSEGTKRQRSEGATRQRTDGAKRQRSERAKSQWSEGVKRQRSEGAKRQRSEGTKRQRSEGAKSQRSEGAKRQRSEESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6H8</accession>
    <name>A0A401P6H8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007254">
        <property type="protein sequence ID" value="GCB68718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6H8"/>
    <dbReference type="STRING" id="75743.A0A401P6H8"/>
    <dbReference type="OMA" id="HYCCNIT"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="228"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="396" mass="44748" checksum="6BD4CF5EB13D8081" modified="2019-05-08" version="1">MSELNRHLLYKSLWADLSWMGLQATLISNADHMYLFADTHQYDDTSQKSENLTDVVNVTFIDRSGRRIPVKGKVGDNILHLAHENGIELEGACLSWSIQQQGVCKRWRRLAYDKGLWKDVNLTPYKVNSRILWHLVRHYLGGTLRTLRVKGVLHSVKKHESLTEALLLEIGKRCPNLSELRLIEMNLRGISYECLPPSLLSLELTHCEIPLQWFRVAAVSNRTRVPPQIKNLEVDNVPNFSDQHLQNLASRTALKVLILSGTYRVTDSGIEKSVASLSEVVHLKLHGCNISDDSLRHIARHLTQLRTLDLTNFCSMTDAGLTCLGGLRSLQSLCFEYCDQITVEKLLAVCTGLPSLNKLNLNGNLYSEGDLHRIRQSLPNCTVTNDFPDMDSMATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6V3</accession>
    <name>A0A401P6V3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005931">
        <property type="protein sequence ID" value="GCB68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6V3"/>
    <dbReference type="STRING" id="75743.A0A401P6V3"/>
    <dbReference type="OMA" id="THELYHN"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20816">
        <property type="entry name" value="C1_GMIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000016">
        <property type="entry name" value="Rho GTPase activating protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057028">
        <property type="entry name" value="RHG29_45_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF18">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24235">
        <property type="entry name" value="RHG29_45_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="515"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="574"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="841"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="807"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="911"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114541" checksum="CC78433E16CBD7F7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P713</accession>
    <name>A0A401P713_SCYTO</name>
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        <recommendedName>
            <fullName evidence="6 7">Fascin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0008300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fascin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0030027">
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="beta-trefoil_FSCN1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-trefoil_FSCN1_rpt2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
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    <dbReference type="InterPro" id="IPR010431">
        <property type="entry name" value="Fascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024703">
        <property type="entry name" value="Fascin_metazoans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551:SF39">
        <property type="entry name" value="FASCIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="140"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="264"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="388"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="489" mass="54590" checksum="0CBF3183DB2C371C" modified="2019-05-08" version="1">MPANDPSNSLQIQFGLINCGKKYLTAEAFGFKINASAATMKKKQIWTLEQNGEDSNVVFFKSHLGRYLAADKDGKVWCESEQPAADCRFLIVAHDDGRWSLQSEPHKRYFGGTEDRLTCFAQTISVAEKWSVHIAMHPQANLFSVTRKRYAHLSAKDELAIDRDTPWGVDSLITLVFQDQKYSLQCSDNRFLRNDGLLVEKPERGTGYTLEFRSGKVAFRDCEGKYLAPSGPTGTMKAGKSTKVGKDELFVLEQSHPQVVLKAANGRHVSIRQGMDLSANQDEESDQETFQLEINKETKKCAFRTCTGKYWTLTSNGGVQSTASTKNGNCYFEIEWRGQRIVLKAANGKYVAAKRNGQLCASVETPAETEEFLMKLINRPIIALRGEHGFIGCRKVTGTLDANRSSYDVFQLELNDGAYRLKDSTGKYWMVGSDSSVTSSSDQPVDFLFEFCDYNKVAIKIDGKYLKGDHAGVLKASADGIDSSTLWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8M5</accession>
    <name>A0A401P8M5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 163</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0005479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001710">
        <property type="protein sequence ID" value="GCB69458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8M5"/>
    <dbReference type="OrthoDB" id="5980560at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12069" checksum="3A0D4B57EECF22C6" modified="2019-05-08" version="1" fragment="single">MESPPPPDVPTASTNQAAPEPRDGGQSSSSPGRPKETFKMDRDNEMRISESAQFGDTVENRGLLESSQKLKPHEAQSYRKKALWVSWVSIVITLSLAVVAFTVSIMRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8P3</accession>
    <name>A0A401P8P3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004588">
        <property type="protein sequence ID" value="GCB69509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8P3"/>
    <dbReference type="STRING" id="75743.A0A401P8P3"/>
    <dbReference type="OMA" id="WHREGYE"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26787" checksum="A3FEBB423E1CF5F1" modified="2019-05-08" version="1">MLRSVLVTGSNRGLGLELVRLLAQAEPPPHNLFACCRQPESPGAQDLVNLAKSYSNINVLKLDVDDFGSIQECADQIEKILGNNGLNLLINNAGVNFGGDLNEVTPETMMKSYRTNAVGPMMVTKALLPALQRAAQLNDKFKAIVINISSILASMELFDNKSGTTYAYRVSKAALNMVTKCLADELKLHGILCTSVHPGWVKTEMGGEKAPLTKEESVRGILKVLSTLSDKDSGSFLDWRGQRLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAL2</accession>
    <name>A0A401PAL2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006091">
        <property type="protein sequence ID" value="GCB70132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAL2"/>
    <dbReference type="STRING" id="75743.A0A401PAL2"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051491">
        <property type="term" value="P:positive regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF1">
        <property type="entry name" value="MYOSIN-IIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB70132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21541" checksum="8D60198B4262DF86" modified="2019-05-08" version="1">MMVFLKYYQIEQLNLLLREVIASIVVIQAHIKGWLGARRYKKAQAKKQSSAIIIQSAWRGYVAHNIYTQLKTQREAAICIQTGVRGYLARKQYKALKESHMLATEQENQITACGPHNDCEQISSPISYNEARNRDINEKNEEDKKASGEVANQLSPKETQPQAHPIMKGKATFGVKSYRSQFSLCTTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB05</accession>
    <name>A0A401PB05_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01001789">
        <property type="protein sequence ID" value="GCB70303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB05"/>
    <dbReference type="STRING" id="75743.A0A401PB05"/>
    <dbReference type="OMA" id="LRENMQX"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08597">
        <property type="entry name" value="PI-PLCc_PRIP_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000017">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000001">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF84">
        <property type="entry name" value="INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="492"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="608"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB70303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="829" mass="94586" checksum="90BE93A22CBF2DB5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBC4</accession>
    <name>A0A401PBC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein CASC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0001276</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000279">
        <property type="protein sequence ID" value="GCB70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBC4"/>
    <dbReference type="STRING" id="75743.A0A401PBC4"/>
    <dbReference type="OMA" id="HPEERHG"/>
    <dbReference type="OrthoDB" id="657902at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028544">
        <property type="entry name" value="CASC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13434">
        <property type="entry name" value="PROTEIN CASC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13434:SF0">
        <property type="entry name" value="PROTEIN CASC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="19">
        <location>
            <begin position="116"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="217"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB70423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="720" mass="80323" checksum="9EA1010D11E03605" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBV3</accession>
    <name>A0A401PBV3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0001321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000293">
        <property type="protein sequence ID" value="GCB70601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBV3"/>
    <dbReference type="STRING" id="75743.A0A401PBV3"/>
    <dbReference type="OrthoDB" id="6136903at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04103">
        <property type="entry name" value="Centaurin_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01250">
        <property type="entry name" value="PH_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000109">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000178">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF1">
        <property type="entry name" value="ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="797"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="717"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="856"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB70601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="894" mass="98512" checksum="39A9A1C9FF2C1AA0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC24</accession>
    <name>A0A401PC24_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0001342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000297">
        <property type="protein sequence ID" value="GCB70672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC24"/>
    <dbReference type="STRING" id="75743.A0A401PC24"/>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000060">
        <property type="entry name" value="Connector enhancer of kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010599">
        <property type="entry name" value="CNK2/3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF12">
        <property type="entry name" value="CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06663">
        <property type="entry name" value="CNK2_3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="316" mass="35309" checksum="CD9A82128BA05786" modified="2019-05-08" version="1">MWSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPNGVILTLKKRPQNTLTSAPALLKNVRWKPLALQPVIPTSPTSSSTTPTSTIGISSKYDSSTLHDVFILSPLSGIYSPRDELGIMPCDDIGKYGMAKSGMKGPESSSYFLDHESGKYYTLMEGEGLPMSSEYERGRATGIRRREKTPTHGDLRPLSMPTEYSWLGESKEPNTYKRGSREDSLLRYLSDDKILIIQEEPMTQRDGKRDTARSSRRRKNPGSPSYPISPSVLTAPVRLDPTSQDILNFPLPESNTVPLYHCNLAPKPQLEYNPHLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC69</accession>
    <name>A0A401PC69_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000300">
        <property type="protein sequence ID" value="GCB70707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC69"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12413" checksum="35FAF4D377F8A751" modified="2019-05-08" version="1">MDSGLKPEKLNLDARLPEATEIFKYWLQCFEAYLNTPETKVDGPRKLSLLHARVGHRLSSVIEKATTYETAVEILQKRFVKVRPITGQVECPPESGLKVPVKMAEGTTESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDG4</accession>
    <name>A0A401PDG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 152 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0005859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001890">
        <property type="protein sequence ID" value="GCB71155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDG4"/>
    <dbReference type="STRING" id="75743.A0A401PDG4"/>
    <dbReference type="OMA" id="LRACHQE"/>
    <dbReference type="OrthoDB" id="10064205at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051235">
        <property type="entry name" value="CEP152/SHC-Transforming"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057664">
        <property type="entry name" value="CEP152_PLK4_bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337:SF6">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 152 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337">
        <property type="entry name" value="SHC TRANSFORMING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25769">
        <property type="entry name" value="PLK4_bind_CEP152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB71155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="90745" checksum="77B616E590F778CF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEZ2</accession>
    <name>A0A401PEZ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger matrin-type protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U11/U12 small nuclear ribonucleoprotein 20 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0006033</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001967">
        <property type="protein sequence ID" value="GCB71675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEZ2"/>
    <dbReference type="STRING" id="75743.A0A401PEZ2"/>
    <dbReference type="OMA" id="WPPIQEL"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000741">
        <property type="entry name" value="Zinc finger matrin-type protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB71675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19767" checksum="24EF333B23CAA03A" modified="2019-05-08" version="1">MGKTYFCDYCGRSFQDNLHNRKKHLQGVQHQRAKKFWFDCFRDNATILAEELAKKPCRKFLQSGQCDFGANCKFSHMTDEDVQQLRQTVEEENKVGHRDRPVPDIDEWLAKRAKRKESNPHSSGLELEKEVDDKPVYWLPPGYHAVHELPPSLHPPPPAGWKTALNVEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH37</accession>
    <name>A0A401PH37_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0006288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002094">
        <property type="protein sequence ID" value="GCB72404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH37"/>
    <dbReference type="STRING" id="75743.A0A401PH37"/>
    <dbReference type="OMA" id="SAHEWSP"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12639">
        <property type="entry name" value="RRM3_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000069">
        <property type="entry name" value="CUGBP Elav-like family member 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="290"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB72404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="375" mass="39999" checksum="CB02CEC146402756" modified="2019-05-08" version="1">MPLKPGNFIQVATTHDATIIGWVSFGRINRFDCSGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIQFGAYGAYAQALMQQQATIMASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAATPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPTAEAVFANGIHPYPGSAHEWSPEARQDVSSGPRCALLLFTRAGSPVLPIGQAGDENSNQMWHTVSSVCTHAQSPTAADPLQQAYAGVQQYAAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ51</accession>
    <name>A0A401PJ51_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0006642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002276">
        <property type="protein sequence ID" value="GCB73135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJ51"/>
    <dbReference type="STRING" id="75743.A0A401PJ51"/>
    <dbReference type="OMA" id="KYSEWIC"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10465" checksum="108FCA1FBEB7B436" modified="2019-05-08" version="1">MDALKKKMQMLKLEKENAMDKADQAEVEKKAAESRCMQLEEEITSLQKKQKATEDELDKCSETLRNTQGKLELAEKKATDVSHYDDTIPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMM2</accession>
    <name>A0A401PMM2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000960">
        <property type="protein sequence ID" value="GCB74404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMM2"/>
    <dbReference type="OrthoDB" id="10629741at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="263" mass="24896" checksum="CBE671E24F94E305" modified="2019-05-08" version="1">MSMGEKESVIGGTGGLNVGETESVIGKIGAVSVGEKESVMGGTGAMSMAEIESGIGGPGAVSVRETESVIGGIRAVSVGETGSVIGGTGAMSMAETESGIGGPGAVSVEETESVIGGTGAVSVGETESVIGGTGAVGMCETESVIGGTGAVSMGETESVIGGTGAVRMGETESVIGGTGEVSVGETESVIRGTGTVSVGETESVIGRTGAVSVGETELVIGGTGAVSVGVTEPVIGGTGAMSVGETESVIGGTGLVTIEKQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNY2</accession>
    <name>A0A401PNY2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible transcript 4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDIT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017422">
        <property type="protein sequence ID" value="GCB74860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNY2"/>
    <dbReference type="STRING" id="75743.A0A401PNY2"/>
    <dbReference type="OMA" id="QDHTSWH"/>
    <dbReference type="OrthoDB" id="10018535at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.40">
        <property type="entry name" value="RTP801-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012918">
        <property type="entry name" value="RTP801-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038281">
        <property type="entry name" value="RTP801-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478:SF17">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE TRANSCRIPT 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478">
        <property type="entry name" value="DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07809">
        <property type="entry name" value="RTP801_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB74860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="191" mass="21537" checksum="DE4D95BB4214733E" modified="2019-05-08" version="1">MVASCSKNKSPGCVSRLLEGECEPPEVLGHAANINYWDHEVTATNVNEEEQTCLYLTKLFENSLSRAKKTKLNCSEVLVPERLIRKIARDVLCLSSSEPCGLRGSVIYINMEIENMCKRLDRIVYDSSVVPTFELTLIFKQDGNSWPSLRDFFFIGTCFTSGFRQALKLSPGFCLIKKKLYCSSARTVIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPH5</accession>
    <name>A0A401PPH5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0019692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014908">
        <property type="protein sequence ID" value="GCB74951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPH5"/>
    <dbReference type="OMA" id="MAYRRAC"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="12221" checksum="976DD481493A49FF" modified="2019-05-08" version="1">MPGQVSSHSALIFSLSIAGGICSWVTLREGTYSGSPIDASDTVDYPELTLDGSGSGFPIDDPELHSGMEVDPGGKPTGSNVEVPKKMPTYAICPVVLLLAAKLLVLLGIVLYFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPQ7</accession>
    <name>A0A401PPQ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="7">PARP</shortName>
            <ecNumber evidence="7">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0020882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01017549">
        <property type="protein sequence ID" value="GCB75107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPQ7"/>
    <dbReference type="STRING" id="75743.A0A401PPQ7"/>
    <dbReference type="OMA" id="QDINDRN"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF89">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB75107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="154" mass="17224" checksum="2F2DE3A99F215162" modified="2019-05-08" version="1" fragment="single">IERLQNPFLWKNYMIRKQLLEEKNPAGTTNEMILFHGTAQDTLDSISHLGFNRSYAGRNATAYGNGTYFAVHANYSAGGTYARVDANGFKHMYRARVLTGVFCRGAAGMVTPPAKNPANPTDLYDSVVDNVQAPSMFIIFNDIQAYPEYLITFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPW3</accession>
    <name>A0A401PPW3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0020317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM147 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016256">
        <property type="protein sequence ID" value="GCB75091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPW3"/>
    <dbReference type="STRING" id="75743.A0A401PPW3"/>
    <dbReference type="OrthoDB" id="9993532at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB75091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="109" mass="12478" checksum="9BC1C8BD3CC63058" modified="2019-05-08" version="1" fragment="single">RCIPLWVGARGIEFDWKYIQMSFDSNISLVHYITMAGLVWMFSRYDLPRHYRLPIAVLLGLSVYKAFLMESFVHVLLLGSWTALLIKAMVTGAISLSSLILYINLVHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQX3</accession>
    <name>A0A401PQX3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012496">
        <property type="protein sequence ID" value="GCB75529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQX3"/>
    <dbReference type="STRING" id="75743.A0A401PQX3"/>
    <dbReference type="OMA" id="AGMFLNQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="139" mass="15620" checksum="23432B119C1D34A0" modified="2019-05-08" version="1" fragment="single">IKNTCPCLAQPGTTIFNDDDEQSDEFLKFRVTSEEKMMLDLLKYAKGIPSDAINKLDIEEVLNIDNEALVFHSMTDGEIAGMFLNQGDHDDKSEDEDDIVNTKVKVSLDVMVKMCNGRIEGIEGRAFITEQEKSCLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRD5</accession>
    <name>A0A401PRD5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Collectrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011232">
        <property type="protein sequence ID" value="GCB75671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRD5"/>
    <dbReference type="STRING" id="75743.A0A401PRD5"/>
    <dbReference type="OMA" id="KFENMAT"/>
    <dbReference type="OrthoDB" id="9899436at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051957">
        <property type="term" value="P:positive regulation of amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042944">
        <property type="entry name" value="Collectrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031588">
        <property type="entry name" value="Collectrin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46884">
        <property type="entry name" value="COLLECTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46884:SF1">
        <property type="entry name" value="COLLECTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16959">
        <property type="entry name" value="Collectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52010">
        <property type="entry name" value="COLLECTRIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019166097" description="Collectrin-like domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Collectrin-like" evidence="12">
        <location>
            <begin position="31"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB75671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="230" mass="25730" checksum="1E61A327D405176E" modified="2019-05-08" version="1">MSFGILLLAFNLFLATEWGATAVSHFCFKGSPYAHKVRISLNAALGDQAYVWDECEQFYFQATVAYGMRKSMNKPFNVSDVHICAETKRISFYFVVTNSSDLSKPLPKTAVEEAIRMVRPRFNNAFSLDDRTLEFLGIEPTLAPHSEPSVMVWLIVFGVIMGLIVVGLIAITIIGHRDKIKKTRASKERDEENEDKSLSGIENGISCNTLDGTEGHKNEALYPDDKLTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRZ0</accession>
    <name>A0A401PRZ0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012565">
        <property type="protein sequence ID" value="GCB75885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRZ0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="47" mass="5186" checksum="101865D6326E2E2D" modified="2019-05-08" version="1" fragment="single">MCEITQSVPPMCEIMQSVPPMCEITQSVPPMCEITQSVPPMCEITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSV5</accession>
    <name>A0A401PSV5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reprimo-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015223">
        <property type="protein sequence ID" value="GCB76188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSV5"/>
    <dbReference type="STRING" id="75743.A0A401PSV5"/>
    <dbReference type="OMA" id="STLIGCC"/>
    <dbReference type="OrthoDB" id="9828700at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043383">
        <property type="entry name" value="Reprimo_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28649">
        <property type="entry name" value="PROTEIN REPRIMO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28649:SF3">
        <property type="entry name" value="REPRIMO-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB76188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11948" checksum="6CC247665BBDD4CC" modified="2019-05-08" version="1">MNSTFFNQTVVEEGFYPSKGPAGLGTVIGCCNQSSVTTDGSLSLNQEEQKLFIMRVVQIAVLCVLSLTVIFGIFFLGCNLMIKSESMINFLVKDRRPSKDVEAVIVGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUH4</accession>
    <name>A0A401PUH4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017942">
        <property type="protein sequence ID" value="GCB76758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUH4"/>
    <dbReference type="STRING" id="75743.A0A401PUH4"/>
    <dbReference type="OMA" id="CWIKEII"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16550" checksum="A5D9DD1F7641690C" modified="2019-05-08" version="1">MCSNHHGATPLVLAKRRGVNKDAIKLLESLEEQEVKGFNRGAHSKLEIMQTAENESEQEIQNNTIRGWETDHQPLSAMESHSLLNPNLQNTDGVLSSFRSTWQEFVDDLGFWRVLLLIVVIALLSLGIAYYVSGVLPFVENQPELVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV74</accession>
    <name>A0A401PV74_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010184">
        <property type="protein sequence ID" value="GCB77040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV74"/>
    <dbReference type="STRING" id="75743.A0A401PV74"/>
    <dbReference type="OMA" id="NICIVES"/>
    <dbReference type="OrthoDB" id="10062065at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="24"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="274" mass="31851" checksum="E70D28C4646AEC82" modified="2019-05-08" version="1">MEHKRAMLCWITRKSNKNTVDQQLEEQMRKTIQYYFEVLKRVVAVMKFLSERGLAFRGHEEKWGSPNNGKFMGAIELIAEFDPFLHEHLEKCKNEKVNATYLSKPVCEELIEIMGKHVQDEIVNQINNLDTKYYSIIVDSMPDLTHVEQLVIVFRYCYNGKTCERFLTFLPIENHSSTTLFNKIQQVLGEHKLSLENIRGQSYDNASNMKGSEKGLQALFKNINRYADYVPCAVHSLNLVEEKAVSTVPEVVDYFGILQELYVFFSGSPQRWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVQ6</accession>
    <name>A0A401PVQ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0020554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016771">
        <property type="protein sequence ID" value="GCB77244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVQ6"/>
    <dbReference type="STRING" id="75743.A0A401PVQ6"/>
    <dbReference type="OMA" id="CKIEDAC"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000039">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB77244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10103" checksum="BED693EF99978599" modified="2019-05-08" version="1" fragment="single">WEFLRSYTAMKNGCLSSPCWNGGTCYADVGEYNCTCRTGYSGWSCEIENDNCASNPCENGGWCQNSATQYKCSCETGYHGLNCELGKVPPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX80</accession>
    <name>A0A401PX80_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 115</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012958">
        <property type="protein sequence ID" value="GCB77722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX80"/>
    <dbReference type="STRING" id="75743.A0A401PX80"/>
    <dbReference type="OMA" id="EIHFWEV"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB77722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38241" checksum="07533F8D7AA8D4F4" modified="2019-05-08" version="1">MSRYLPVARQHFLAAAASTSVVVKSVCGTVLSLYCLSFLLDTVHGLGVTPGYLFPPNFWVWTLLTHAVVENHIWDVAVGLGAVVLAGRLLEPLWGALELLIFFTVLNVSVGILGGLSYLLTYVATFNLDYLFTVRIHGMWGFVGGMLVALKQTMGDTVVIKVPQVQMKDVPMVLLAIIGVLRLTMLLSSSLLTSYGFGLLSSWVYLRFYQKHSRGRGDMSDHFAFATFFPEILQPPVSMVANVIYSVLVKIRICKKAVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQVAWPSMDEDDKEDLSDMPLLPESNKSDGDDSGAAEHIAFQGLSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY95</accession>
    <name>A0A401PY95_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein misato homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0021159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018256">
        <property type="protein sequence ID" value="GCB78013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY95"/>
    <dbReference type="STRING" id="75743.A0A401PY95"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="9">
        <location>
            <begin position="100"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB78013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="255" mass="28190" checksum="C3D7FD81DB2275BE" modified="2019-05-08" version="1" fragment="single">DAALCYDGESSEPYSDIGNNVLFREGLTLRGQATYTPRLILMDLKGSLSSLKQEGALYGGEVDSSRNLNSTAFQGEERAAPLSVAARPLDLSHGTYRLESNVRVWSDYLRVHLHPKTISVIQQYNHSSTADRFEAFGFGEKLMRDPSFLDDFEDRLHFYIEECDYLQGFHVLCDLQDGFAGLSAKVVELLNDEYGGRGIFTCGFTPTSYADTVSMEGSGRTVCGHTLHSKHLSLGPGWTLSVCPSWDAVGIKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYK6</accession>
    <name>A0A401PYK6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0018568</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013057">
        <property type="protein sequence ID" value="GCB78170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYK6"/>
    <dbReference type="STRING" id="75743.A0A401PYK6"/>
    <dbReference type="OrthoDB" id="9941998at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF18">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB78170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="296" mass="33378" checksum="7DF11556A89E1F8F" modified="2019-05-08" version="1">MLAFAAESFTEDRTGLDAESPFLQYQPTAGYAAAHTDTEVEKDEEQDSDLVQVLDFSPALEPEPETGSVQCLISPETDQSEMSALLEEVDRLHVGSNEEQEQGFKVLLDNKNKYGKRREFCWRMIRAYSDMTQLTEDKETQKCYALAGRDEATASLQDHGDSIECQIWLAVVCRHLQDHDVEDRSEENSNLKETRAEADVPIEDVNSYESLDSDPANISVTSTSQVTEATENNEEQDVQAQHEGNILVDAIHSYDNIYTQHYAMSITDIAAMEDRNKEEDMQAIEEANLMVEFIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYV7</accession>
    <name>A0A401PYV7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase ZFP91</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase ZFP91</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zinc finger protein 91 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0020663</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with MAP3K14/NIK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01017040">
        <property type="protein sequence ID" value="GCB78337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYV7"/>
    <dbReference type="STRING" id="75743.A0A401PYV7"/>
    <dbReference type="OMA" id="FARRADC"/>
    <dbReference type="OrthoDB" id="7852576at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000183">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000356">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB78337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="11712" checksum="26601D722DDB5547" modified="2019-05-08" version="1" fragment="single">QRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADANYQFSCNVCGKKFEKKDSVVAHKSKSHPELVIAEALAESTEVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q028</accession>
    <name>A0A401Q028_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017131">
        <property type="protein sequence ID" value="GCB78718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q028"/>
    <dbReference type="STRING" id="75743.A0A401Q028"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF69">
        <property type="entry name" value="INTEGRIN ALPHA-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10212" checksum="5173CF85C72FDA7A" modified="2019-05-08" version="1">MGAPGSYYWTGTVKVYSLKEGKYYHFEDPTIGARHYRYLGYAVGTGHFTHPSSLEIVGGAPQDEGIGKVYIFKIDNDKLTAIFTIPGKEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q093</accession>
    <name>A0A401Q093_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009236">
        <property type="protein sequence ID" value="GCB78814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q093"/>
    <dbReference type="STRING" id="75743.A0A401Q093"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF4">
        <property type="entry name" value="PLEXIN-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSI" evidence="4">
        <location>
            <begin position="47"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="210" mass="23827" checksum="9BFB9F6AC68154CB" modified="2019-05-08" version="1">MNVIRPIVLYEFENESPIRHKVAFDALDPNYLYLAANMEVRRIKVASCAKYKSCTDCLSAKDPYCGWCTLNKRCSFANECENSNNSVYWITIKEKINSCPEVTMSPLAIDDSFKNTKLFTVKGRGKLSNFMNENTTCTLRIARNNEVICTASNITKCSCQVSNNMYTQLKNQPDPVTIEVLIESGSLNYTTQFTVHNCYKIAEARFNNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0A2</accession>
    <name>A0A401Q0A2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009241">
        <property type="protein sequence ID" value="GCB78839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0A2"/>
    <dbReference type="OrthoDB" id="10666477at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="15587" checksum="5628136AFB6EE6F9" modified="2019-05-08" version="1">MSVTLVSMSDSVELIKQQEKERPEYNHILLQDPDEKKIQEVLENFQEATQEDQRKHRKKRKGKRLSRSNESSDDFRDSVWQQQQGDQRDNVLKYTKGRLSELDDDHQEPTNEDDNVVEERLDELENRIMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4B4</accession>
    <name>A0A401Q4B4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010842">
        <property type="protein sequence ID" value="GCB80212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4B4"/>
    <dbReference type="STRING" id="75743.A0A401Q4B4"/>
    <dbReference type="OMA" id="KSKDGMC"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10590">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041417">
        <property type="entry name" value="NPEPL1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF4">
        <property type="entry name" value="AMINOPEPTIDASE NPEPL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18295">
        <property type="entry name" value="Pdase_M17_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="443" mass="47151" checksum="3A8A65A5F5BEE698" modified="2019-05-08" version="1" fragment="single">MKGGGGGDGAGIERLLFTASAGDADPQSRPLLLVGQLPNLQKIIWSQVKGKLEPRVNQEVWQAALNTLNPNPIDSCSLWLDNAVVAALPSKISRHNSPSSAHFLTRLIRNCSSRRTNRCIVIVCEYTEVFASACALTRAFPLFTRRTGLPKQGEKLTVTVEFILVGENANPLTESTLACLLSAAEGIRIAARIVDTPCNEMNTDDFLAEIELVGSELGIIPTVIRGEELNDRGFGGIYGVGKAAVTPPALAILSHKPEGATQTIAWVGKGIVYDTGGLSIKSKTCMPGMKRDCGGAAAVLGAFRAAVKQGFKENLHALFCLAENAVGANATRPDDIHQLYSGKTVEINNTDAEGRLVLADGVSYASKDLKADIILDIATLTGAQGIATGKYHAGLLTNSEEWERACVKAGRNSGDLVQPMVYCPELHFSEFTSAVADMKNFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4L1</accession>
    <name>A0A401Q4L1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0016159</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009598">
        <property type="protein sequence ID" value="GCB80312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4L1"/>
    <dbReference type="STRING" id="75743.A0A401Q4L1"/>
    <dbReference type="OMA" id="HGKWNIT"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005410">
        <property type="entry name" value="2pore_dom_K_chnl_THIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF10">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01588">
        <property type="entry name" value="THIKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="89"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB80312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="296" mass="32912" checksum="97C6A85E90F228F3" modified="2019-05-08" version="1">MTTPTTVAGKVFLIFYGLLGCAGTILFFNLFLERIITLLAFIMKACYQRQLRRKGLLPPTIRRQSAIMDTASLAGWKPSVYYIMLILGVAAIIISCCASAMYTPVEGWNYTDSLYFCFVTFSTIGFGDLVSSQNAAYTNQGLYRFGNFVFILLGVCCVYSLFNVISIVIKQFLNWLLKKLECRCCPRCRRGKMRTGRRNAITPGQSRIHRNHILADAEGPCDSDGEGRRLSGEMISMRDLTASNKVSLAILQKQLSETANGYPRTVCINTRQNGFSGGVGALAIMNNRLAETSECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q510</accession>
    <name>A0A401Q510_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010958">
        <property type="protein sequence ID" value="GCB80448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q510"/>
    <dbReference type="STRING" id="75743.A0A401Q510"/>
    <dbReference type="OMA" id="TINYKHG"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF6">
        <property type="entry name" value="CALCIUM UNIPORTER REGULATORY SUBUNIT MCUB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB80448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="306" mass="34854" checksum="027CEEFC79B04C0B" modified="2019-05-08" version="1" fragment="single">VTVEYKHGFPVISIMLPSRKERCQFPVKPLLMNVGDLLKDLKNEDRGINSAAIFSEDGTRVSATTPISILLTKNFELVINETKYFVKPPTKDYMSSEHCVEMDNVKSLVHRLYIALHAENHQLHKQGQLLEKLENLKGELQNLEQIKSQLFLKAEAKSSQLMWVGLALMSTQAGALAWLTWWVYSWDIMEPVTYFITYGSSMGFYAYFLLTRQDCVYPDVKDRQFLHYFHRGAKRSSFDIEKYNKIKEELAEESEGYGGTCRACDGTTATGEVTKIRNVQETEITMDGFGNLDEKSLVTSCAALTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5G3</accession>
    <name>A0A401Q5G3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">MsrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0017247</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:21260"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58773"/>
            <dbReference type="EC" id="1.8.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011046">
        <property type="protein sequence ID" value="GCB80605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5G3"/>
    <dbReference type="STRING" id="75743.A0A401Q5G3"/>
    <dbReference type="OMA" id="CSKCEHQ"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052150">
        <property type="entry name" value="MsrB_Met_sulfoxide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46755">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46755:SF5">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="18">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB80605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10148" checksum="61B61D86FF0AF72C" modified="2019-05-08" version="1">MAFCSFFGGEVYKKHFEAGIYICSKCGHELFSSRAKYDHSSPWPAFTETIHPDSLSKRKDGESALKVSCGKCGNGLGHEFPNDGPKKGQARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5K3</accession>
    <name>A0A401Q5K3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0016285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009756">
        <property type="protein sequence ID" value="GCB80627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5K3"/>
    <dbReference type="STRING" id="75743.A0A401Q5K3"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19489">
        <property type="entry name" value="Rad51D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047323">
        <property type="entry name" value="Rad51D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048943">
        <property type="entry name" value="RAD51D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21794">
        <property type="entry name" value="RAD51D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="12">
        <location>
            <begin position="78"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="445"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="507"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB80627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63511" checksum="D5CC94A880B3A46E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q642</accession>
    <name>A0A401Q642_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0022077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021120">
        <property type="protein sequence ID" value="GCB80835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q642"/>
    <dbReference type="STRING" id="75743.A0A401Q642"/>
    <dbReference type="OrthoDB" id="8942860at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514:SF4">
        <property type="entry name" value="NESPRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514">
        <property type="entry name" value="PKA ANCHORING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="52018" checksum="5A97B7CE159AF4F8" modified="2019-05-08" version="1" fragment="single">VTQLEPIFSSRLQLWAEYQDSYEQVNGNILRAQYSLEHCTPLSRSLASSQLQLESLQTLQDTVESGAESWRKFQAISEQLSRECCPAQTQQLDKTCEDTHCRWVQVNQDVTEQLYTARTECQLWGQFRDIYQSTLAKVRGFEDRSRHLLIELSLDDSTQEKLQTQLVETQESLRDLRALQEDVFQVGVAADALATRMDSSSCAALQSHCRYLSGKVSNLERLLTVKKPDIQDLMEQHEDFHRYLHTLETLVNESEEVLKSEDPGPEQVGGFCLETLMGHLLRFSSNSLRLEALKHLSSQLPLSDLDYRRVQALHQRWEQARATARDQCSLCENLLMILFVSKHREGNLQYHEPRYVRTLELGRELLSAADSTTKTSLEGQLSQLQEAWESTNLQLKAKIMQLTNIEKMCDRCGQEVAELGAKLGEFGADMKKELTQSSEDLKREKNKLQVRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6E3</accession>
    <name>A0A401Q6E3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019918">
        <property type="protein sequence ID" value="GCB80945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6E3"/>
    <dbReference type="STRING" id="75743.A0A401Q6E3"/>
    <dbReference type="OMA" id="FMLNIRN"/>
    <dbReference type="OrthoDB" id="9629570at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001230">
        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019357601" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="16535" checksum="A94F52211602B3EE" modified="2019-05-08" version="1" fragment="single">MISAIQLIWPLAFCIAGISGDTIMTQSPPVLSVSLGQTATITCTASQSATTDVEWFQQREGQKPALLIYDAVHRFTGISDRFTGRELSTTRFTLTISNLQNEDVADYYCQQSRENSQPTLTLLPPSLEEVKTKGTATLVCLANHFYPDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6I1</accession>
    <name>A0A401Q6I1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027704">
        <property type="protein sequence ID" value="GCB80973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6I1"/>
    <dbReference type="OMA" id="LQYSLRH"/>
    <dbReference type="OrthoDB" id="9397715at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162:SF20">
        <property type="entry name" value="GLUTAMINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="452" mass="48945" checksum="74A8E30B43219120" modified="2019-05-08" version="1" fragment="single">AQHSTEQCSAVQRSTVQSSAVQRSTVQSSTAQHSTEQCSAVQSSAVQRSTVLRSTEQCSTAQYSTVQSSAVQYSAAQYCAVQSSAVQRSTVQSSAVQYRAVQYSAAQSSAVQHSAAQHRAVQHSAAQSSAVQYSAAQYRAVQYSAAQSSAVQRSTVQSSTAQYRAVQYSAVQSSAVQRSTEQCSTAQYRAMQYSAAQCRAEQCSAAQRSAVQYSAAQSSAVQRSTVQSSAVQYSAVQSSAVQRSTEQCSTAQHSAVQCSAVQRSAVQYSTVQHRAVQYSAAQYRAVQRSTAQHSTEQCSTEQCSAVQRSTVQSSAVQRSTVQSSAVQRSTEQCSTAQHSAVQYRAVQCSTAQYRAVQYSAAQYSTVEQCSAVQRSTVQRSTVQSSAAQYRAVQYSTVQLSALQCSAAQWDREKRTQNSLQALRSIKPSKELGPFEEFFKKRWAPSTKVHRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6N6</accession>
    <name>A0A401Q6N6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zona pellucida sperm-binding protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zona pellucida glycoprotein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0022449</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZP domain family. ZPC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022541">
        <property type="protein sequence ID" value="GCB81021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6N6"/>
    <dbReference type="STRING" id="75743.A0A401Q6N6"/>
    <dbReference type="OMA" id="YNDHENC"/>
    <dbReference type="OrthoDB" id="8880842at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032190">
        <property type="term" value="F:acrosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035803">
        <property type="term" value="P:egg coat formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000344">
        <property type="term" value="P:positive regulation of acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4100:FF:000002">
        <property type="entry name" value="Zona pellucida sperm-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017977">
        <property type="entry name" value="ZP_dom_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11576">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11576:SF2">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00682">
        <property type="entry name" value="ZP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="17">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB81021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="262" mass="29378" checksum="797A56D08B51BD5B" modified="2019-05-08" version="1">MRLMNGDWLTERSSTVYYLGDLIHIEASVSMSNHMPLKLYIDRCVATLSPDKDSTPRYSIIDYNGCLLDSKAEDSFSTFVLPSGEREMDKLRFDLDAFRFFGDDHSLIFITCHLKVTPVDRRGSRNKACTFQMMQNIWTPLEESSIDICACCRVGNCATRELRFGSRGRRDLVAEAESEVGLRWEAEAPLGPLIILDTDVTNLATDSLNEGRMQERSPGGVGSEVVLIVTLTVTAVSLISASLITLFLYRKHNQTLFTQSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6P1</accession>
    <name>A0A401Q6P1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018650">
        <property type="protein sequence ID" value="GCB80997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6P1"/>
    <dbReference type="STRING" id="75743.A0A401Q6P1"/>
    <dbReference type="OMA" id="WIAIYGP"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="246" mass="27612" checksum="F41431DD46F9D151" modified="2019-05-08" version="1">MSDHDDDGSEPFLAQRDLAAEAMAADMDPWVIFDGRKTPRAEFDDWLDSNRPSRVFRHGELDHNAEPVGWIAVYGPASSPAPQRGDAEGLQEDWERLLSSGRLVTFETVKELALNRRVLSGKWLMHLDTGFKVDHAWGSIARAVLDGRVPAAKVSPYCPSSDAKHVICVPGDNFTDESQVVRLDAAIRAVGIKCPLSYKPDAYTYLGLYRGNRWKLCPTIYESRYDLECIPRRSRITSKVTMTELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6Q2</accession>
    <name>A0A401Q6Q2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0021774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019964">
        <property type="protein sequence ID" value="GCB81056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6Q2"/>
    <dbReference type="STRING" id="75743.A0A401Q6Q2"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042371">
        <property type="entry name" value="Z_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042361">
        <property type="entry name" value="ZBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14966">
        <property type="entry name" value="Z-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14966:SF0">
        <property type="entry name" value="Z-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02295">
        <property type="entry name" value="z-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00550">
        <property type="entry name" value="Zalpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50139">
        <property type="entry name" value="Z_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Z-binding" evidence="5">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Z-binding" evidence="5">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB81056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="495" mass="53980" checksum="3C3050FC01DF1CCB" modified="2019-05-08" version="1">MSRGGGGDRRTQKRKAKGFPQYNQLHDHQTSNPLYQGAGTDHFRSQQIRFLTGQISQLPACVFQPLYRSQALYQQKQRSRFQPAAKNWDGNFCQQPVRSPRPPAAPAQQADKNPRPDKRLDPLFSAFQNISLGGNSRQEIVSVLGKLRPGERIPARKITKQLGVQKKVVNQILYGLLGENRVVKEGTSPPLWRLAGQTEARAEVANLEGQQGSPGNTALPLPSEVEEEESEDEDSSEDSMADRASIGDGESQKDKILSFLLEKEKATALEIAKNIGLKSARQINPTLHLFETQGDLYKEAAFPPIWSLSDRKKEVLLRKKKVHEMGEPIFGAVQGIPVAVPDVSQDDIEGVAVGEEESIGNGQAVGLPGQTNDFQTLSTSAPLLLVKGESNRANHAEANYYDSTTGNGQWASDDIPDDLNIINRVSEAGETVGLPQGVLAGKAGADQQPVLSPTDRLRACLTKNPVSGLMEYSQGSALQCEFILLAQTGPSHDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q920</accession>
    <name>A0A401Q920_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thrombospondin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020446">
        <property type="protein sequence ID" value="GCB81870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q920"/>
    <dbReference type="STRING" id="75743.A0A401Q920"/>
    <dbReference type="OMA" id="WHRLELH"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="214" mass="24687" checksum="AA844768BACEFD78" modified="2019-05-08" version="1" fragment="single">MRCPLFQYFRLVFPRGLPQDFTFLATLLLKKKKLKENWYMLKINDQQRRSQFSIRIDGGDKTVEYKAKGRFQDYVRWVFSSEGVAALFDLRWHKLAISVQANVASLYIDCQLIEIKSVEERADIDIKGQTVMGRLVKDSMPAEVDLQQMILFCDPLIAEKVMCCEIPGVRCATESLIPKSRRNAEVKNPRAALPQMTGKVHTKCFCVDKDTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9K7</accession>
    <name>A0A401Q9K7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019253">
        <property type="protein sequence ID" value="GCB82050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9K7"/>
    <dbReference type="OrthoDB" id="10011458at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010457">
        <property type="term" value="P:centriole-centriole cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038810">
        <property type="entry name" value="CNTLN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18957">
        <property type="entry name" value="CENTLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18957:SF0">
        <property type="entry name" value="CENTLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="10754" checksum="FE2E4F4C0738D365" modified="2019-05-08" version="1">MELQHQNAALDKRLNQMAEQQALVTKSADESSSAASIHASNVPVSPHKLMETELKQLKSKLKNATNEISKHLTTIKTLKAEHQEKDEQIRQLQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDF0</accession>
    <name>A0A401QDF0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIPBL protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01032338">
        <property type="protein sequence ID" value="GCB83428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDF0"/>
    <dbReference type="STRING" id="75743.A0A401QDF0"/>
    <dbReference type="OMA" id="IVAICCP"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048703">
        <property type="term" value="P:embryonic viscerocranium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11666" checksum="990D69C81D1E0F07" modified="2019-05-08" version="1">MHEAVEVMDVIAICCPKYKDRPQIARVVEKTSSGFSVHWMAGSYSGSWTEAKRREGRKLVPWVDSIKESDIIYKKIALTSANKLTNKVVQTLRSLYAAKEGSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDN7</accession>
    <name>A0A401QDN7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01041233">
        <property type="protein sequence ID" value="GCB83495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDN7"/>
    <dbReference type="STRING" id="75743.A0A401QDN7"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="139" mass="14949" checksum="02C0A3C21490FF2C" modified="2019-05-08" version="1" fragment="single">AVCGNTPVVNYSDSRTAEVICESASKMITFIDLAGHHKYLKTTIFGLTSYCPDFAMLVVSANTGIAGTTREHLGLAMALKVPFFIVISKVDLCTKATIDRTVKQLEMVLKQPGCNKVPLLVSSSDDAVTAAQQFAHSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDU7</accession>
    <name>A0A401QDU7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0024354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01044064">
        <property type="protein sequence ID" value="GCB83588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDU7"/>
    <dbReference type="STRING" id="75743.A0A401QDU7"/>
    <dbReference type="OMA" id="GAVKCKK"/>
    <dbReference type="OrthoDB" id="9948298at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005021">
        <property type="term" value="F:vascular endothelial growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045446">
        <property type="term" value="P:endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF552">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB83588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="138" mass="15453" checksum="E90BE4E09132181B" modified="2019-05-08" version="1" fragment="single">VSQRNLQSEINIMNKLGYHKNIIQLLQWNITQEPYILIMEHVSRSLKGFLQNNRPELCGCKDLQIQLTSAAYFISLGMEHLASKKIVHRDLAARNILLGRFPQECKIGEFGLAADLSNAGAVKCKKGRGVSISNPPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE02</accession>
    <name>A0A401QE02_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01047913">
        <property type="protein sequence ID" value="GCB83572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE02"/>
    <dbReference type="STRING" id="75743.A0A401QE02"/>
    <dbReference type="OrthoDB" id="10616307at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF4">
        <property type="entry name" value="RAS-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10859" checksum="C0CCE3B0D5C11CF9" modified="2019-05-08" version="1" fragment="single">MTVSENNGDVAVIKMAELIPGLQPLIYWMSNSIELLHFIQQEVPILLTWEQHMDQYACHNDQFSSTKAASEEAMTVLEEVIMFTFQQSVYYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE14</accession>
    <name>A0A401QE14_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01048043">
        <property type="protein sequence ID" value="GCB83625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QE14"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="13847" checksum="E083601621F27E78" modified="2019-05-08" version="1">MGSILGQCGAPGDAGGGYPGDDGNQGTPGSKGYQGRPGLPGVDVRGPKGRRGFPGDFGPDGVPGIPGIPGLPGTPGDCVDEQQILLIDGTIFHSGIGWIMLRVCRLLLGLKLIIVILTEILGVGMKDCFPWLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QED8</accession>
    <name>A0A401QED8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01039239">
        <property type="protein sequence ID" value="GCB83712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000288216">
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    </dbReference>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF10">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8510" checksum="0D9CC2ABB4F2174E" modified="2019-05-08" version="1" fragment="single">LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKELALLKATHAQVRKRAKVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF75</accession>
    <name>A0A401QF75_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01058143">
        <property type="protein sequence ID" value="GCB84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="13369" checksum="4E14441A65156CB9" modified="2019-05-08" version="1" fragment="single">SLSAGTIVPVDAPWGVYGYLENGKIQQKFRVFLEIVPGVINPPEPTDPTVKTVFTPPVWYYTRSFDKKVDEQQIEERVIQLLKDLEQDNQPFKGTYFVIAFFNIRGLMIVAFEKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFS5</accession>
    <name>A0A401QFS5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01053606">
        <property type="protein sequence ID" value="GCB84203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFS5"/>
    <dbReference type="STRING" id="75743.A0A401QFS5"/>
    <dbReference type="OrthoDB" id="7457481at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="246" mass="27493" checksum="CE46E18A7015969D" modified="2019-05-08" version="1">MQYKLEPEAQTVQFNLEPEVQAVQLNLESGHQDVQSTQEPEEPEAHVVQSVQSELEPVAQIVQSNLEPEAEAEQDNLEPEAEAVRSKLGPKGKAVQSNLEPETQAVPFNLEPEAQAVQPKLEPEAQVVQSNQEPKAQAVQSNQEPEAQAVLSNLEPEAQAVQSNQEYEAQAVQSNLKPETQAVQFNLCSLAWSLRQRLCSLTRSMRPRLCSLNWSLRPNLCKLTWSLRPSLCSLIWSLRPRLCSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI20</accession>
    <name>A0A401QI20_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0025671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01115590">
        <property type="protein sequence ID" value="GCB84977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QI20"/>
    <dbReference type="OMA" id="AKAMTYD"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
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        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF246">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB84977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="99" mass="11443" checksum="8F742116F2694EE5" modified="2019-05-08" version="1" fragment="single">PLKKAAKQAALADDSEEEEEAQPMSYDEKRQLSLDINKLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQKKTYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI83</accession>
    <name>A0A401QI83_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01125748">
        <property type="protein sequence ID" value="GCB85099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI83"/>
    <dbReference type="STRING" id="75743.A0A401QI83"/>
    <dbReference type="OMA" id="QNYIFAS"/>
    <dbReference type="OrthoDB" id="8920197at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1010">
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
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            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="484" mass="51264" checksum="BCFC5E484E3A21A1" modified="2019-05-08" version="1" fragment="single">SDRAAEQSDPAAEQSEPVAEQSDPVTEQSDPATEQSDRAAEQSDPVAEQCDPVTEQSDPVAEQSDPTAVQSDPVTEQSDPVTQQSDPVTEQSDPATEQSDPVAEQSDPVTEQSDPATEQSDPVTEQSDPAAEQSDPSDPVTELPDPVTEQSDPSAEQSDPVTEQSDPVTEKSDPAAEQSDPVTEQSDPVSEQSDPAAEQSDHVAEQTDHVAEHPDPVTEQSEPVTEQSDPATEQSDRVTEQSDPAAEQSDPVTEQSDPAAEQSDHVAEQSDPVTEQSDPAAEQSDPVTEQSDPVTEQSDPAAEQSDHVAEQSDPVTEQSDPVTEQSDPAAEQSDPVTEQSDPVTEQSDPAAEQPDHVAEQSDPVTEQSDPVTEQSDPVAEQSDPVTEQSDPAAEQSDPVTVQSDPGTEQSDPVTEHSDPATEQSDHVAEQSDPVAEQSDPVAEQSDPVTEQSDTVTEQPDHVAEQSDPVTEQSDPGKEQSDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJV5</accession>
    <name>A0A401QJV5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01185928">
        <property type="protein sequence ID" value="GCB85687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJV5"/>
    <dbReference type="STRING" id="75743.A0A401QJV5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="198" mass="23095" checksum="92DA5969EB291BB0" modified="2019-05-08" version="1">MKERDVCGRDSMKDRKESGRATVKEHEESHRDSMKDREESGRDSMKERDVCGRDSMKDRKESGRDTVKQHEESHRDSMKDGEESSSDSMKDREESGRDTVKEREESGRDKVKEREDSGRDTLKEREESGRDTVKECEESGRDTVKERAESGRDTVKEHEESGRDTVKEREESGRETVKEREESGRDTVKEREESVRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKG1</accession>
    <name>A0A401QKG1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0026578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01216546">
        <property type="protein sequence ID" value="GCB85860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QKG1"/>
    <dbReference type="OMA" id="LPPDCDQ"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB85860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="136" mass="14816" checksum="9B4EAF04A6A4DCB8" modified="2019-05-08" version="1" fragment="single">GRYREASVQVIAVMSRFAVIERASIDEAYVDLTAAARQRARQMEGQRVDTGLLKTTFVEGFSQNGQAQQSGDPATLKEEGRRAGIEAWLDSLPPDCDQNSPELQLTAGALIVEEMRAAVETETGYRCSAGISHNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKJ3</accession>
    <name>A0A401QKJ3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01214561">
        <property type="protein sequence ID" value="GCB85899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKJ3"/>
    <dbReference type="STRING" id="75743.A0A401QKJ3"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="13611" checksum="3019BB3B8CEEEC44" modified="2019-05-08" version="1" fragment="single">VDAALGAEEMVETLTEWNLDLEEKVRQLRETVSDLEAINEMNDELQENSRETELELREQLDLAGARVREAEKRVEAAQETVADYQQTIKKYRELTSHLQVTLKNPSNCSTPNKLFHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLR9</accession>
    <name>A0A401QLR9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain coiled coil stalk domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01272501">
        <property type="protein sequence ID" value="GCB86324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLR9"/>
    <dbReference type="OrthoDB" id="9950059at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18280" checksum="9A65D7FF32A9E749" modified="2019-05-08" version="1" fragment="single">IPMALGAAKEIERCEELIKNTTEAKGVLKTGCEQKEKALECGNEKIKELKLKRVEGVANLREKEVELAALKGEVDLLLAVGEKISDNASYITKLEGLLKMLNRQCSVETFYGIVGMKSILDKIFTCIQEEGFDDWLRDFNINRKLSELEEKITTFHRIYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM57</accession>
    <name>A0A401QM57_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01296791">
        <property type="protein sequence ID" value="GCB86465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM57"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="14445" checksum="67358C3CCD4BB3C3" modified="2019-05-08" version="1" fragment="single">LKKGRFTSLEKERFASLEKGRFASWEKGRFASLVKGRFACMEKGWFASLEKGLFAGLEKGRFASLENGWFARLEKGRIASLNNGGFPSLEKGPFADLEKGRFASIEKGRFTSFEKGQFASLEKGRFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMK4</accession>
    <name>A0A401QMK4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01327542">
        <property type="protein sequence ID" value="GCB86610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMK4"/>
    <dbReference type="STRING" id="75743.A0A401QMK4"/>
    <dbReference type="OMA" id="VKLYMSV"/>
    <dbReference type="OrthoDB" id="8964540at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="247" mass="27775" checksum="0A754D69B03A22B1" modified="2019-05-08" version="1" fragment="single">MTVKLDRTVKLVTTVTLDMTVKLDMTVKLDMTVKLYMSVKLDMSMKLDVTVKLDMTLKLDMTVKVVTTVKLDMTVKLDMTVKLDMTVKLDMTVKLAMTVKLDMTVKLGMTVKLDMTVKLDMTVKLAMTVKLDRTVKLDMTVKLDMTVKLAMTVKLAMTVMLNMTVKLATTVKLDRTVKLDMTVKLDMTVKLAMSVKLAMTVMLDMTVKLATTVELDMSVKLDMTVKLDMTVKLDMTVKLDMSVKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QP82</accession>
    <name>A0A401QP82_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01423113">
        <property type="protein sequence ID" value="GCB87186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QP82"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="14139" checksum="4FE1DCCDE8B2F697" modified="2019-05-08" version="1" fragment="single">MKEGKSERNEMKESKRERNETKESERERNETKAGERERNEMKEGERERKEKKEGQRERNETKKGERERNEMKERGRERNETKEGERERNETKEGQRERHETMEGERERNERKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A223AB91</accession>
    <name>A0A223AB91_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HoxD9</name>
        <name evidence="16" type="ORF">scyTo_2000072</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-06" db="EMBL/GenBank/DDBJ databases">
            <title>Lethenteron camtschaticum and Scyliorhinus torazame Hox genes.</title>
            <authorList>
                <person name="Pascual-Anaya J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="MF398264">
        <property type="protein sequence ID" value="ASS31220.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAA01001523">
        <property type="protein sequence ID" value="GCB66750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A223AB91"/>
    <dbReference type="STRING" id="75743.A0A223AB91"/>
    <dbReference type="OMA" id="MRSWMEP"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000018">
        <property type="entry name" value="Homeobox A10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006711">
        <property type="entry name" value="Hox9_activation_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017112">
        <property type="entry name" value="HXA9/HXB9/HXC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45970">
        <property type="entry name" value="AGAP004664-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45970:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04617">
        <property type="entry name" value="Hox9_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037109">
        <property type="entry name" value="Homeobox_Hox9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ASS31220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB66750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="265" mass="30147" checksum="529DD3A9920A4396" modified="2017-10-25" version="1">MSTSGTVQNYYVDSLIGQEAEDLYAARFAQGSHSTAPRPSGVADSSDFSSCSFTPKSTAFSSPWSAVHPQPSAAVAGIYHPYMHQSHLAAGDSRYVRSWLEPLSSSVSFPGFHPNGRHYGIKPETLSGKRAECSSFELQTLSLPEFACGSYPECRDKLPKEIGCTSSETTSNSERKEEKQQQLDPNHPAANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRRMKMKKMNKVKNNEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHA8</accession>
    <name>A0A401NHA8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004935">
        <property type="protein sequence ID" value="GCB60254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHA8"/>
    <dbReference type="STRING" id="75743.A0A401NHA8"/>
    <dbReference type="OMA" id="EFQFRES"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000002">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000101">
        <property type="entry name" value="SWI/SNF-related, matrix-associated, actin-dependent regulator of"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF54">
        <property type="entry name" value="SWI_SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="157"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="452"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="805"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="981"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="119423" checksum="FE9E11666D502E40" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKJ3</accession>
    <name>A0A401NKJ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0011301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005084">
        <property type="protein sequence ID" value="GCB61372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKJ3"/>
    <dbReference type="STRING" id="75743.A0A401NKJ3"/>
    <dbReference type="OMA" id="SGKMPHR"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01396">
        <property type="entry name" value="MeCP2_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.890.10:FF:000003">
        <property type="entry name" value="methyl-CpG-binding domain protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032343">
        <property type="entry name" value="MBD2/MBD3_p55-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025884">
        <property type="entry name" value="MeCpG-bd_2/3_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396:SF0">
        <property type="entry name" value="METHYL-CPG BINDING DOMAIN PROTEIN-LIKE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14048">
        <property type="entry name" value="MBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16564">
        <property type="entry name" value="MBDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MBD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB61372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="266" mass="30081" checksum="FDBE4FFD724E3F50" modified="2019-05-08" version="1">MERKRSDCPCLPPGWKKEEVIRKSGLSAGKSDVYYYSPSGKKFRSKPQLARYLGNSIDLNSFDFRTGMMMANKLQRTKQRLRNEAINQSKGKLDLNTTLPIRQTASIFKQPVTKVTDHPNNKVRSELQRITEQPQQLFWEKRLQGLSACDIAEQIIKSMELPKGLQGIGPGHTNEALLSAIASALHTSSGPITGQLSAAVEKNPAVWLNIYQPLCRAFVVTDKDIRKQEERVHQVRKKLEEALMADELARAEEERHVDREQCDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKK0</accession>
    <name>A0A401NKK0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003784">
        <property type="protein sequence ID" value="GCB61394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKK0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="60" mass="6800" checksum="EF18C2EEF17519AC" modified="2019-05-08" version="1" fragment="single">WGTSISNSRRNGRVKGISRTSDLDVGYTTQACRKDNWKLRIEILPDCIPWITVCSKATCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKS9</accession>
    <name>A0A401NKS9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0004095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001183">
        <property type="protein sequence ID" value="GCB61449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKS9"/>
    <dbReference type="STRING" id="75743.A0A401NKS9"/>
    <dbReference type="OMA" id="WNGQLER"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF3">
        <property type="entry name" value="ERC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB61449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="321" mass="38109" checksum="8BB4806C59B7F4AD" modified="2019-05-08" version="1">MIFFAGIPERIQFYSSLREFLQKNLHFVQKDPDFENFFNLSEARYNFRIQFLDLSEEKDKPLSLVTSGNAVTSWNGQLEREAVTGGRVLTHLTQRHTNHVRDNTMVDLQAQLKDLQRENEILRKELEIKDTKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEESQHLQLTIQALQDELRTQRDLNHLLQQENVNRGAEHYTIELTEENFRRLQAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSMEEEHERSRRISEAESQVNHLEVLLDQKEKENNHLKEVCFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLF5</accession>
    <name>A0A401NLF5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nucleoporin Nup37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Nup107-160 subcomplex subunit Nup37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0007093</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002508">
        <property type="protein sequence ID" value="GCB61706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLF5"/>
    <dbReference type="STRING" id="75743.A0A401NLF5"/>
    <dbReference type="OMA" id="XPILTGS"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000168">
        <property type="entry name" value="Nucleoporin Nup37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 22" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB61706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="328" mass="36861" checksum="8208820D6C64B4F7" modified="2019-05-08" version="1">MLVNDGAARRASHTVPSEETVHVVEFNPFESCGAGSLVAYGGDNYIVVGNCRFQEEDAEIKGMEYKTLQTFHRGIRVDSIAWSPETKMDTLTQLIRFCAADADRKLRLLTSDLKQNTRWQVIEGHTDYINDLVFDPNTGKQIASVSDDHTCRIWDLDGNQKTSFLLHSPGMSLCWHPEEMYKLMVAEKDGIIRFYDLVSLQAILSLDCGQMPLLSADWCLGNTIKVGAVAGNDWLIWDITRSSYPQEKRPSHLDGARRFRWSKANENLFATTGYPGKMNSQLLVHHLGHPQAIMLGSAPVASGLSWHRTLPLCAIGGDRKILFWMTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLL3</accession>
    <name>A0A401NLL3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mRNA decay activator protein ZFP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Zinc finger protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006444">
        <property type="protein sequence ID" value="GCB61775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLL3"/>
    <dbReference type="STRING" id="75743.A0A401NLL3"/>
    <dbReference type="OMA" id="TQRRHSC"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061158">
        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900153">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB61775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="300" mass="32928" checksum="8720E3AF30C3B70A" modified="2019-05-08" version="1">MSGLKDLCELVSGLSFLDSDDLSPIQLGLDYRTVKPPAGFRRHSTSLVPPGRCQALAPGDSSCPPGLGRCLSHGNSLEEFGKSAMGASDRPPAQQQQQQPSPRYKTELCRPFQESGICRYGDKCQFAHGLGELRILSRHPKYKTELCRTFHSCGICPYGARCHFVHNPEEERASRPLSARPRLRQSTSFSGFSSDGLVGLCPGSRGSLSLSPPPCSDLPDWDSLREAVSQEFARVMKLTCSSCHKHLKPAAQPQADMSFRSPYADSLSDQEDYSSSGSESPIFDQNRRLPIFSRISVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLQ3</accession>
    <name>A0A401NLQ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Genetic suppressor element-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002518">
        <property type="protein sequence ID" value="GCB61792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLQ3"/>
    <dbReference type="STRING" id="75743.A0A401NLQ3"/>
    <dbReference type="OMA" id="ERNHELN"/>
    <dbReference type="OrthoDB" id="8744624at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022207">
        <property type="entry name" value="GSE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042337">
        <property type="entry name" value="GSE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17608">
        <property type="entry name" value="GENETIC SUPPRESSOR ELEMENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17608:SF4">
        <property type="entry name" value="GENETIC SUPPRESSOR ELEMENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12540">
        <property type="entry name" value="DUF3736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Genetic suppressor element-like" evidence="3">
        <location>
            <begin position="743"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB61792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1197" mass="134303" checksum="8969095F086C7E57" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM29</accession>
    <name>A0A401NM29_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo like helical domain containing 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003850">
        <property type="protein sequence ID" value="GCB61951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM29"/>
    <dbReference type="OMA" id="KIARNHI"/>
    <dbReference type="OrthoDB" id="278163at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041090">
        <property type="entry name" value="DUF5578"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17741">
        <property type="entry name" value="DUF5578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40082" checksum="6C7B1FFDB6AAD88D" modified="2019-05-08" version="1">MASSKEEMEMSKLMSFLQEWDNGDKAVRHRILSDFINTNKGKTGPELELQFAQGASLFLTRLTAWLRLTYMVGTCVTEQLQAIGVFLSATSGHRYLIEVLEVGGVLTLLEILKLKQLREDNKEEALKLLQIIANAGRKCKEIICESYGVRNVAECLANSKLEKTQEQAQILLELLAQGNPKYQQQVYKGLIALLPCTSPKVQQLALQTLRPLQMLVKTVHPCIVEPLLNVLKTIHYEVQYEGIEFIKILLDYNVRKALLEGLVTRLNPSMDDIKNRPKILDDEPTTKLTESTPLFVQQAAAAKVIGILIQESAEIAEELLQFRVVHNLLIAMGNLDHADSQRHASLTLEVSILLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM52</accession>
    <name>A0A401NM52_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl-CoA hydratase domain-containing protein 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0009429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003850">
        <property type="protein sequence ID" value="GCB61956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM52"/>
    <dbReference type="STRING" id="75743.A0A401NM52"/>
    <dbReference type="OMA" id="WRSVAFS"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000022">
        <property type="entry name" value="methylglutaconyl-CoA hydratase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF44">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB61956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="34717" checksum="7842E8621353F897" modified="2019-05-08" version="1">MSVVCVGSLTAPGRGGLARSGIGMSLQTVLTSLTRGGLGSTWGRVTSLAVSRRRCSNISGPTEIHVQRLQGENSGIATVLMSRPHARNSLGNVFVKQLEEAIEDLHQDKSLRVVLFKSQVKGIFCAGADLKERAEMSNTEVGHFVHKLRSLMSNIELLPMPTIAAIDGYALGGGLELALACDLRVAASSAKMGLIEVTRGLLPGAGGSQRLPRVVGIGMAKELIFTGRRIDGKQAMSIGLVNDTVAQNDLGDAAYQKALDLAKEILPQGPVALRMAKQAMNKGIEVDISSGMAIEEMCYAQVIPTRDRLEGMAAFKEKRLPHFTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNN3</accession>
    <name>A0A401NNN3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Groucho/TLE N-terminal Q-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0000042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000005">
        <property type="protein sequence ID" value="GCB62483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNN3"/>
    <dbReference type="STRING" id="75743.A0A401NNN3"/>
    <dbReference type="OMA" id="YYEMSHA"/>
    <dbReference type="OrthoDB" id="8949191at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF31">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="9">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB62483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="24964" checksum="BE1398845E677115" modified="2019-05-08" version="1">MGVMTRPRTSPQLHTTVTNALNFALTRDKREGEGKKRGRCIRKPDSRLKLECDKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVIPFLSQEHQQQVVQAIERAKQVTAPELNTVIRQQLQAQQLSHLHGLTVPLTPLPAGLQPPVIPSVSASAGLLALSSALGSQIHLATKDDKNHHDGDHQRDEGGGRAGLIYSTAEQPNMDYLQNNMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNW1</accession>
    <name>A0A401NNW1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0004272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 14"/>
    <dbReference type="EMBL" id="BFAA01001255">
        <property type="protein sequence ID" value="GCB62575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNW1"/>
    <dbReference type="STRING" id="75743.A0A401NNW1"/>
    <dbReference type="OMA" id="FAINIRV"/>
    <dbReference type="OrthoDB" id="675023at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF8">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="12">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="13">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB62575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="14406" checksum="03177677F0C21520" modified="2019-05-08" version="1">MRLTRKVSVWPVGLVGGRRYERPLVEQGRVVGWYTGWRPDRPFAIDMAGFAVNLKVILSHPKAVFKRSGSQPGMQESDFLKQITTVQELEPKAANCTKVLVWHTRTEKANLVFEPKHNQDVIHIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPM7</accession>
    <name>A0A401NPM7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Peptidyl-prolyl cis-trans isomerase E</fullName>
            <shortName evidence="16">PPIase E</shortName>
            <ecNumber evidence="4 16">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0007288</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Interacts (via RNA-binding domain) with KMT2A (via the third PHD-type zinc-finger).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 16"/>
    <dbReference type="EMBL" id="BFAA01002611">
        <property type="protein sequence ID" value="GCB62816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPM7"/>
    <dbReference type="STRING" id="75743.A0A401NPM7"/>
    <dbReference type="OMA" id="HARWCEM"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000348">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016304">
        <property type="entry name" value="PPIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001475">
        <property type="entry name" value="PPI_cyclophilin_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 16" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="19">
        <location>
            <begin position="144"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB62816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="302" mass="33668" checksum="CD792A7E5D9D35BE" modified="2019-05-08" version="1">MATTKRVLYVGGLAEEVDEKVLHAAFIPFGDIMDIQIPLDYETEKHRGFAFIEFENAEDSAAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRAVWSDDDWLKKFAGKTLKENENEEQGGDDGNTQTQEGEPPAKKTRINPQVYMDIKIGNKPVGRLRFLLRADVVPMTAENFRCLCTHEKGFGFKGSSFHRVIPQFMCQGGDFTNHNGTGGKSIYSKKFDDENFILKHLAPGLLSMANSGTNTNGSQFFITLDKTDWLDGKHVVFGEVVEGMDVVKQIEAQGSKDGKPKQKVIISDCGEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRM7</accession>
    <name>A0A401NRM7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TELO2-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001319">
        <property type="protein sequence ID" value="GCB63561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRM7"/>
    <dbReference type="STRING" id="75743.A0A401NRM7"/>
    <dbReference type="OMA" id="NHCSQGQ"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="42053" checksum="3AD26CC635284676" modified="2019-05-08" version="1">MSHLPTISPDCVLRAILPHLVIFCATHCQEKAWTSAASRLAADELLAAGVQAAGCKSVTELLCGTEEKGRGVLGAVLHLMKPQMNKNTWKLNPATKHVFRWLLQRVRRPWLAEHLDVVLPPSLLFSDDYRTENKILGVRCLQHIIDNVPAAELLQYNRAQVVYHALYNHLYTPEPSLIQTVLSCLLDLLPLLEKSHVTRGQQRANRYDKVFCLILTHMEVEDKIPLRRVYAKHLPIFTERLGILVVRHLKRLQRVILGYLEVYDGPEEAARLCVLQAFQSMIQQAWPRMSMRLEVLLKSLLKFIYDMATDQSPTPPRVKEELLQDATHCLILLNRCCERKVTVLLEGVRQSCENATVLDCLQRVQQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS15</accession>
    <name>A0A401NS15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005371">
        <property type="protein sequence ID" value="GCB63656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS15"/>
    <dbReference type="STRING" id="75743.A0A401NS15"/>
    <dbReference type="OMA" id="HTNQPEF"/>
    <dbReference type="OrthoDB" id="332250at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022027">
        <property type="term" value="P:interkinetic nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903724">
        <property type="term" value="P:positive regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022136">
        <property type="entry name" value="DUF3668"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12416">
        <property type="entry name" value="DUF3668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="450"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB63656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1003" mass="115506" checksum="37DAB825BFA17232" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSA1</accession>
    <name>A0A401NSA1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine vasopressin-induced protein 1/transcriptional and immune response regulator domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000033">
        <property type="protein sequence ID" value="GCB63778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSA1"/>
    <dbReference type="STRING" id="75743.A0A401NSA1"/>
    <dbReference type="OMA" id="LENECYA"/>
    <dbReference type="OrthoDB" id="8681175at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002264">
        <property type="term" value="P:endothelial cell activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020282">
        <property type="entry name" value="Avpi1/C8orf4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039580">
        <property type="entry name" value="Tcim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32358">
        <property type="entry name" value="TRANSCRIPTIONAL AND IMMUNE RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32358:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL AND IMMUNE RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15063">
        <property type="entry name" value="TC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginine vasopressin-induced protein 1/transcriptional and immune response regulator" evidence="1">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="12270" checksum="E71E10F1285F6931" modified="2019-05-08" version="1">MATTLENECYAHRVSPQLVSGQRFDTDLRKRAAPNIFEAVNQAALQRLFERSGDKRAEERARIIATNQDNEHITRSLVALKLRKRMKFMQLFRIGRESVTMLSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSA4</accession>
    <name>A0A401NSA4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005389">
        <property type="protein sequence ID" value="GCB63803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSA4"/>
    <dbReference type="STRING" id="75743.A0A401NSA4"/>
    <dbReference type="OMA" id="HDINEGY"/>
    <dbReference type="OrthoDB" id="6268231at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="14573" checksum="2756CCD1A186B98B" modified="2019-05-08" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRSVITPRYPLFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSY0</accession>
    <name>A0A401NSY0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005406">
        <property type="protein sequence ID" value="GCB63959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSY0"/>
    <dbReference type="STRING" id="75743.A0A401NSY0"/>
    <dbReference type="OMA" id="EQTENCH"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.20:FF:000001">
        <property type="entry name" value="sentrin-specific protease 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.20:FF:000004">
        <property type="entry name" value="sentrin-specific protease 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF2">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="663"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="788"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB63959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="986" mass="112231" checksum="5C1D04C0C22129CE" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTE3</accession>
    <name>A0A401NTE3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0004545</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine.</text>
            <dbReference type="EC" id="2.3.2.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-Cys relay (RCR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.33" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01001349">
        <property type="protein sequence ID" value="GCB64114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NTE3"/>
    <dbReference type="OMA" id="LERETMC"/>
    <dbReference type="OrthoDB" id="6050183at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
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        <property type="entry name" value="Bbox2_MYCBP2"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase MYCBP2 isoform X1"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase MYCBP2 isoform X1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="APC_su10/DOC_dom"/>
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        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_E-set"/>
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        <property type="entry name" value="PHR"/>
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    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
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    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RCCNDNSATION"/>
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        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="929"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="980"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="13">
        <location>
            <begin position="2307"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="domain" description="DOC" evidence="18">
        <location>
            <begin position="3661"/>
            <end position="3839"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="4364"/>
            <end position="4415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1959"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2696"/>
            <end position="2715"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2721"/>
            <end position="2863"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2897"/>
            <end position="2962"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="3128"/>
            <end position="3164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="3859"/>
            <end position="3884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1964"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2721"/>
            <end position="2731"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2732"/>
            <end position="2744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2765"/>
            <end position="2781"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2801"/>
            <end position="2812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2852"/>
            <end position="2863"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2916"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="2929"/>
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        <location>
            <begin position="2943"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="3145"/>
            <end position="3154"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000333"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005415"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012249"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
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    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="GCB64114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="4614" mass="507415" checksum="BD19E2871846BA5B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTG6</accession>
    <name>A0A401NTG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ArfGAP with dual PH domains 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0014731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008017">
        <property type="protein sequence ID" value="GCB64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401NTG6"/>
    <dbReference type="OMA" id="DEIIECM"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01251">
        <property type="entry name" value="PH2_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037851">
        <property type="entry name" value="PH2_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF6">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="107"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="229"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="41930" checksum="D4564064F1FBF0ED" modified="2019-05-08" version="1">MFYYPDWASYTLGVFICLNCSGIHRNLPGISRVKSIRLDFWDDEIIECMRKHGNRVAKKYYEANVPPFYYKPQASDCIVLKEQWIRAKYERIEFTDANTEQQLSVTSGDRVGFLWKRGKDNGNFQERNFRLLGKEGVIFYYTKEDKEPKGVIQVSDLNATFQPEKIGNANGLQMTYLKDGRTRSIFVYHKNGKDIVDWFNAIRAARFRYLKSAFPTNSDAELIPKLTRNYVKEGYMEKTGPRQKEAFKRRWFTLDNQDRKLLYFKEPLDAYAQGEVFIGHSEYGYNVTEGLPPGLKGNKWRLGITIETPERKFVFTCQDDEDLNEWIVAFKEVIFKPMSPQDYTVEASLRRKQKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUW7</accession>
    <name>A0A401NUW7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0013367</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006794">
        <property type="protein sequence ID" value="GCB64650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUW7"/>
    <dbReference type="STRING" id="75743.A0A401NUW7"/>
    <dbReference type="OMA" id="CESPTKF"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000116">
        <property type="entry name" value="Low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000052">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000002">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF15">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019508212" description="EGF-like domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="305"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="430"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="477"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="520"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="564"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB64650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="798" mass="87963" checksum="CE2E5F19ADC421A3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUX5</accession>
    <name>A0A401NUX5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0007565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002775">
        <property type="protein sequence ID" value="GCB64654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUX5"/>
    <dbReference type="STRING" id="75743.A0A401NUX5"/>
    <dbReference type="OMA" id="SESPWTQ"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB64654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="13561" checksum="2817B790CDD1C9CC" modified="2019-05-08" version="1">MAAEDRERDQARSDNAKHKRKEQLKRWLGSETDRESERPRTKQLRVKFAEGAVFLAACSSGDRDEVEKLLLRGGDINYTNVDGLTALHQSLMLDYFKCSDFPDPLRFLYSNSCHALQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWF7</accession>
    <name>A0A401NWF7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0014863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008144">
        <property type="protein sequence ID" value="GCB65201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWF7"/>
    <dbReference type="STRING" id="75743.A0A401NWF7"/>
    <dbReference type="OMA" id="ELNKNCH"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB65201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="119" mass="13322" checksum="C29A36B0FFEF51BD" modified="2019-05-08" version="1">MAARGKLIAVLGDEDTCTGFLLGGIGELNKNRRPNFLVVEKETSVTEIEETFKSFLSRDDIGIILINQYIAEMIRHVIDAHTLSIPAVLEIPSKEHPYDASKDSILRRAKGMFSTDDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ18</accession>
    <name>A0A401NZ18_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001483">
        <property type="protein sequence ID" value="GCB66152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NZ18"/>
    <dbReference type="OMA" id="PWLLTQM"/>
    <dbReference type="OrthoDB" id="9989103at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20420">
        <property type="entry name" value="Tudor_TDRD6_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047444">
        <property type="entry name" value="Tudor_TDRD6_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF15">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="380"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="616"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="898"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1429"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1816"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2411" mass="270519" checksum="4DC15A550E7F4059" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ93</accession>
    <name>A0A401NZ93_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Neuronal acetylcholine receptor subunit alpha-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0007837</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Pentamer of two alpha chains, and one each of the beta, delta, and gamma chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Synaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002910">
        <property type="protein sequence ID" value="GCB66175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ93"/>
    <dbReference type="STRING" id="75743.A0A401NZ93"/>
    <dbReference type="OMA" id="FLVKEDW"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000014">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 19" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022255204" description="Neuronal acetylcholine receptor subunit alpha-4" evidence="19">
        <location>
            <begin position="25"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="34"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="246"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="440"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="524"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB66175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="70727" checksum="E6CF1EFBE23E41FD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZR3</accession>
    <name>A0A401NZR3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001498">
        <property type="protein sequence ID" value="GCB66357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZR3"/>
    <dbReference type="STRING" id="75743.A0A401NZR3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="15172" checksum="59B039689EDA36D2" modified="2019-05-08" version="1">MGERGGRGMGQWEGVGGRCLVWGVGGEGGVTCAAQFPGAEERSDMEMKLWLVLALLVGTAVVYAQDDDDDADIVEDEDDESPIESDPTPSTPPPKVTYRAPVPIGQVHFSESFDKGTLERYERHADIITLGLWGWYCPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P087</accession>
    <name>A0A401P087_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside diphosphate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004295">
        <property type="protein sequence ID" value="GCB66529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P087"/>
    <dbReference type="STRING" id="75743.A0A401P087"/>
    <dbReference type="OMA" id="PDVIWWR"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051766">
        <property type="entry name" value="TXND_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46135:SF4">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46135">
        <property type="entry name" value="NME/NM23 FAMILY MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019484346" description="Nucleoside diphosphate kinase-like domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="3">
        <location>
            <begin position="720"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB66529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="967" mass="107826" checksum="1557706A7CEE633F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1A6</accession>
    <name>A0A401P1A6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0012065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005714">
        <property type="protein sequence ID" value="GCB66894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1A6"/>
    <dbReference type="STRING" id="75743.A0A401P1A6"/>
    <dbReference type="OMA" id="YTEEHML"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22967">
        <property type="entry name" value="DD_AK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047499">
        <property type="entry name" value="DD_AK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB66894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="686" mass="78608" checksum="802A3712756F7EAD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P396</accession>
    <name>A0A401P396_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0015131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008433">
        <property type="protein sequence ID" value="GCB67587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P396"/>
    <dbReference type="STRING" id="75743.A0A401P396"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF24">
        <property type="entry name" value="ZINC FINGER PROTEIN 410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB67587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="264" mass="29110" checksum="E526797083AFCE5A" modified="2019-05-08" version="1" fragment="single">MELKQFSLRSHQRTHTGEKPFTCEVCDKSFSRSSNLRQHRRIHTEKTVPCKVKLSQSTQERSLTGGRVPYIKELTEQEEFTRKLFDFSNSTITNGGSDMGMSKETRVSMDTSNGDEGESAAASKIPERADEEETVVNTSQQCGMAAAVEEGEKCQEGKVPDLEGSVGGLKLNIMVCVKEEACDDLATVMAGGRSEPSRGEEPMALGAEAPPSSRGQHQAHAADEENEDDLKHHEHLHQEQVQSTESCQVTSNLLQETLTEIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3N6</accession>
    <name>A0A401P3N6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000157">
        <property type="protein sequence ID" value="GCB67744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3N6"/>
    <dbReference type="STRING" id="75743.A0A401P3N6"/>
    <dbReference type="OMA" id="ANMEEMV"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="86" mass="9782" checksum="490B08BFEDF1DB5E" modified="2019-05-08" version="1">MVNMEEVARVEEVANMEEMVNMEEVPIVEEVTNMEEMANMEEVANMEEMVNMEEVARVEEVARVEEMTNMEEVANMEGVCMASSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3Q7</accession>
    <name>A0A401P3Q7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004407">
        <property type="protein sequence ID" value="GCB67762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3Q7"/>
    <dbReference type="STRING" id="75743.A0A401P3Q7"/>
    <dbReference type="OMA" id="LPGKWVR"/>
    <dbReference type="OrthoDB" id="1244179at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18390">
        <property type="entry name" value="BTB_POZ_KCTD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2000:FF:000001">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000005">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958:SF12">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="34"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="25395" checksum="D62CBC802584C028" modified="2019-05-08" version="1">MAAVSGSLSELSENFNSSLCRKCSGLERAAAAAKWVRLNVGGTRFLSTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDRIRERDTKTSQIPMKHVYRVLQCQEEELTQMVSTMSDGWKFEQLVSIGSSYNYGNEDQAEFLCVVSRELHNAPYGTNTEPSEKAKILQERGSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3Y0</accession>
    <name>A0A401P3Y0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0015160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008460">
        <property type="protein sequence ID" value="GCB67823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3Y0"/>
    <dbReference type="STRING" id="75743.A0A401P3Y0"/>
    <dbReference type="OMA" id="MDNSHIS"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="9">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB67823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="261" mass="28794" checksum="EFC136A6D8F0F546" modified="2019-05-08" version="1">MFEARLVQGSILKKVLEALKDLITEACWDISSTGISLQSMDSSHVSLVQLTLRSDGFDTYRCDRNLAMGVNLSSMSKILKCAGNDDIITLRAEDNADTLALVFESQNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSQIGDAVVISCAKDGVKFSASGELGTGNVKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSADIPLVVEYKIADMGHIKYYLAPKIEDEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P468</accession>
    <name>A0A401P468_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0005224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001604">
        <property type="protein sequence ID" value="GCB67918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P468"/>
    <dbReference type="STRING" id="75743.A0A401P468"/>
    <dbReference type="OrthoDB" id="382863at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032151">
        <property type="entry name" value="CFAP61_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16092">
        <property type="entry name" value="CFAP61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 61 N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="393" mass="44451" checksum="0825EEEF304EBDC7" modified="2019-05-08" version="1">MAPGRRVTKTSCGFPGTKAAAQTNNDNYICFRWRKSTMFGRINVTYLLERANLSVTVENEKNEVMAHAALLDYPNVEEIEQNNWEPWLHTYGPSSKCTPLNTLFMHLLVAKSEVAGGCAKEIVRSVFNAIRELHFIILAVRKKVALDPAVSVLFAPMPQFRKVEGVNCSAFICYRKDYVPVLHIRQARIEDHDDVTPIFNEQTDTLRHIYGEYFLAELIEAQDETTHAAVSEVNNAAVGFISVCSEVNVDLLNECYDLRPFHGLRKGPDVESAEQQPETTLSSAPSSPKDNADRKTNVTDNIENAKLPAGDAEDQTTEEAESKKEIISKDSESSNSFCIQLFCIDEKYESRSQDFLPFIFNLYPVSESSEPVFYFNEKIIEFNMLQTKDPDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7X6</accession>
    <name>A0A401P7X6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005972">
        <property type="protein sequence ID" value="GCB69235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7X6"/>
    <dbReference type="STRING" id="75743.A0A401P7X6"/>
    <dbReference type="OMA" id="GTGGECQ"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17121">
        <property type="entry name" value="Ubl_UBTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB69235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="234" mass="26273" checksum="810FF46C14438968" modified="2019-05-08" version="1">MGGCVGTQHDSSGSLNENSDGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGASITLPHGVLTECYDELGNRYQLPVYCLAPPINMIEEKSDLETLDIPEPPPNSGQECQLRLRLSTGKDLKLIVRSTDTVYHMKRRLHTTEGVEPSSQRWFFSGRPLTDKMKLEELKIPKDYVVQVIISQPLQTPTPVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAD2</accession>
    <name>A0A401PAD2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004670">
        <property type="protein sequence ID" value="GCB70137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAD2"/>
    <dbReference type="STRING" id="75743.A0A401PAD2"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="62" mass="7156" checksum="2253690693DD99EB" modified="2019-05-08" version="1" fragment="single">AISCHYASSHCYYIDVKGTTQENIEQEILELGRTKYGIYSDLTMADIWFLKGRLVQGERINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAN7</accession>
    <name>A0A401PAN7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0005624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001774">
        <property type="protein sequence ID" value="GCB70172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAN7"/>
    <dbReference type="STRING" id="75743.A0A401PAN7"/>
    <dbReference type="OMA" id="WSIMPLN"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000856">
        <property type="entry name" value="ER membrane protein complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019087169" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="755"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB70172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="961" mass="108716" checksum="A6D7DBA7DAC01A1F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC72</accession>
    <name>A0A401PC72_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ras-related protein Rab-15</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0008657</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB15 may act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">The GTP bound form of RAB15 interacts with REP15. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01003361">
        <property type="protein sequence ID" value="GCB70726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC72"/>
    <dbReference type="STRING" id="75743.A0A401PC72"/>
    <dbReference type="OMA" id="QAHKKEM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000990">
        <property type="entry name" value="ras-related protein Rab-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB70726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="21123" checksum="14341571FAE089A1" modified="2019-05-08" version="1">MCEERTNIQSVPGVDFKMKTIDVDGIKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDITSERSFQHIMKWASDVDEYAPEGVQKILVANKADEEQKRQVGAEQGQKLAKEYGMDFFETSACTSYNIKESFTRLTELVLQAHKKELDGLRLSTADELGIADLEEDDTKIERMDNSQKACWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCJ5</accession>
    <name>A0A401PCJ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000309">
        <property type="protein sequence ID" value="GCB70829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCJ5"/>
    <dbReference type="STRING" id="75743.A0A401PCJ5"/>
    <dbReference type="OMA" id="CEASDFM"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF7">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="1">
        <location>
            <begin position="350"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="468" mass="51206" checksum="169D273969D1E5EC" modified="2019-05-08" version="1">MEEPDPAISPAVHRDLQTDLKVAPTSCSSHSLQLTLGSSSNTSSSKNCSTASCNANSCGTSGYNSSKNCNITCCNTNRNCTTGCNRNCSTASCDNSGCNTYRNSSTTGCSTNRNCSTTSCITSSGCNTYRNCSTASCNNSRIYSIASCNTSRNCSLASCNINRNFSTASCNTSSGCNTSRNCSTASCNTRSCNNSKTCNHGNNCNTSSCKTSCNSQAGDEGKVCELSHQPDGTCPEKEVLVSAGSRQSNELRLNRRRTKSLPCLHDPSDFFSEFNGGLRKKVKFADSLGLSLASVKHFRASDEPYIPSKVFLRLQSFPTIVDDLNEKFKALGIHCMRPAFSMPCEASDFMQRAERNRVCLENVTVRHFDVHGLIRVLNISYIKEVIVRYTFNNWLSSMDTPAKYVEGSSHLGTDQFSFVLSIPPFLDQGSFVHFAICYRTDNEEYWDNNFDKNYSLLCESTSDEHANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDF1</accession>
    <name>A0A401PDF1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tissue factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Coagulation factor III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0005862</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tissue factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001891">
        <property type="protein sequence ID" value="GCB71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDF1"/>
    <dbReference type="STRING" id="75743.A0A401PDF1"/>
    <dbReference type="OMA" id="QGEYERY"/>
    <dbReference type="OrthoDB" id="8704831at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042015">
        <property type="term" value="F:interleukin-20 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001006">
        <property type="entry name" value="Interleukin 20 receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001187">
        <property type="entry name" value="Tissue_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF48">
        <property type="entry name" value="INTERLEUKIN-20 RECEPTOR SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00346">
        <property type="entry name" value="TISSUEFACTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon/interleukin receptor" evidence="17">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="364" mass="41959" checksum="8726237A3CEEAFAC" modified="2019-05-08" version="1">MFTSVFLVSTSGRGLERLPKPNNVFVNSTNMRHILRWSPVRFPLGGITYSVQFQGEFERHHKKTWVVISECSRITETWCDVTADISSDVDYDLKVRSQFENITSKWANLSKLFNRKESNLRTPRLTVNVRGGLLTLDVSEISKNINARIYYWEKGAEQQILNISMDHNPFNVNLRSGITYCFQAQLYISEYNKFSYRSDPICETVNKDATSNEIVVIVTTVLLLGVSIVVVSLFLTWKLCCRVQSAWFPKVSAPYFPNFDTLQVDTIKEEDRRKEFCDTVQVLPQSEPLLSQCQPLTGEERSNCKTDTESWTINSVMSGNVSQLQCPMAIQYWKEYQSQQNSEFSKLTNNGTDTTQIFEEFNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEC2</accession>
    <name>A0A401PEC2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DLGP4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0001584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000361">
        <property type="protein sequence ID" value="GCB71461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEC2"/>
    <dbReference type="STRING" id="75743.A0A401PEC2"/>
    <dbReference type="OMA" id="CPATQDD"/>
    <dbReference type="OrthoDB" id="10036956at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099572">
        <property type="term" value="C:postsynaptic specialization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF19">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB71461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62887" checksum="22F46D4473AD7E18" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFE6</accession>
    <name>A0A401PFE6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003537">
        <property type="protein sequence ID" value="GCB71841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFE6"/>
    <dbReference type="OrthoDB" id="9948541at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="299" mass="32865" checksum="D1E177F47638390E" modified="2019-05-08" version="1">MPVCAHTGCFSPPANSPADVQFDRFKALTTIKSSTPLKGASLFHSKMKTALNDIEDLDDTLLEVEETEVDAVGPLNLASEEIGVILQEFDDNHIDNTVSLVLKCGDMSRITDETVCECKYVSDSQLYLSPPNASNLPENYLVIDETPARYHLCDVSSTDVTVLKVEQEVNQSLNSVQHNPNSLHEGGDIKESNRPYYLSAEEVALFSQPPVCAGEAVDERSHAGSSNEADSRKPSETLVANPASCSPDSLKDRKLTFWEQVTSERVVSVIEEKANDAEVKKNFRSPVHTEHKAKEQKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG29</accession>
    <name>A0A401PG29_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C-Jun-amino-terminal kinase-interacting protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">JNK-associated leucine-zipper protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Mitogen-activated protein kinase 8-interacting protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Sperm-associated antigen 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0009024</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JIP scaffold family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003583">
        <property type="protein sequence ID" value="GCB72100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PG29"/>
    <dbReference type="OMA" id="DXASREN"/>
    <dbReference type="OrthoDB" id="10256043at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1770:FF:000001">
        <property type="entry name" value="C-Jun-amino-terminal kinase-interacting protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1000:FF:000001">
        <property type="entry name" value="C-Jun-amino-terminal kinase-interacting protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000700">
        <property type="entry name" value="Sperm-associated antigen 9a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032486">
        <property type="entry name" value="JIP_LZII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF2">
        <property type="entry name" value="C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16471">
        <property type="entry name" value="JIP_LZII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH1" evidence="17">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="18">
        <location>
            <begin position="492"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="191"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB72100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1316" mass="146796" checksum="67885ED301CDC2D0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG63</accession>
    <name>A0A401PG63_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prospero domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002035">
        <property type="protein sequence ID" value="GCB72117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG63"/>
    <dbReference type="STRING" id="75743.A0A401PG63"/>
    <dbReference type="OMA" id="HRREECH"/>
    <dbReference type="OrthoDB" id="10038576at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070365">
        <property type="term" value="P:hepatocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070309">
        <property type="term" value="P:lens fiber cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001945">
        <property type="term" value="P:lymph vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031016">
        <property type="term" value="P:pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060042">
        <property type="term" value="P:retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035295">
        <property type="term" value="P:tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.500:FF:000001">
        <property type="entry name" value="Prospero homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.500">
        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF9">
        <property type="entry name" value="PROSPERO HOMEOBOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05044">
        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51818">
        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="8">
        <location>
            <begin position="409"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB72117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="569" mass="65268" checksum="00FA425A664DD739" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGA9</accession>
    <name>A0A401PGA9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyprenol dehydrogenase</fullName>
            <ecNumber evidence="17">1.1.1.441</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dolichal reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0006193</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis. Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol. First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by SRD5A3. It then catalyzes the NADPH-dependent reduction of dolichal into dolichol. May also acts as a positive regulator of starvation-induced autophagy.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichol + NAD(+) = a di-trans,poly-cis-dolichal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80735"/>
            <dbReference type="Rhea" id="RHEA-COMP:19495"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16091"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.1.1.441"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:80737"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichol + NADP(+) = a di-trans,poly-cis-dolichal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80731"/>
            <dbReference type="Rhea" id="RHEA-COMP:19495"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16091"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.1.1.441"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:80733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-polyprenol + NAD(+) = a di-trans,poly-cis-polyprenal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80719"/>
            <dbReference type="Rhea" id="RHEA-COMP:19496"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67132"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="EC" id="1.1.1.441"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:80720"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-polyprenol + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80723"/>
            <dbReference type="Rhea" id="RHEA-COMP:19496"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67132"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="EC" id="1.1.1.441"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:80724"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.441" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01002046">
        <property type="protein sequence ID" value="GCB72180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGA9"/>
    <dbReference type="STRING" id="75743.A0A401PGA9"/>
    <dbReference type="OMA" id="CIAYHAM"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000490">
        <property type="entry name" value="Dehydrogenase/reductase SDR family member on chromosome X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB72180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="322" mass="35474" checksum="23A0F8195B423175" modified="2019-05-08" version="1">MLSKEGVEGVRIGFKLGEDNGKREGIFPPQNGKVAIVTGGAKGIGYETAKHLSRLGMHVIIAGNHENQGLLSVGKIVKETGNEKVEFMYLELASLQSIRQFVQRFKAKNALLHVLVNNAAVMLVPQRITADGFEEHFGVNYLGHFMLTELLLDTLKQSGSTDCNSRIVTVSSATHYIGELNLNDLQSRHHYSPHGAYAQSKLALTLFSYQLQQRLAADGSHVTSNVVDPGVVNTDLYKHTSWLFKLCKWLTSWLLFKTSTQGASTVIYVAVSPDLEGSGGSYYANGQKTKSADTSYDEDLQRKLWARSCKLVGILEHRQCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGD8</accession>
    <name>A0A401PGD8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003597">
        <property type="protein sequence ID" value="GCB72168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGD8"/>
    <dbReference type="STRING" id="75743.A0A401PGD8"/>
    <dbReference type="OrthoDB" id="9938627at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07078">
        <property type="entry name" value="FYTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="7772" checksum="5316A77D17E60100" modified="2019-05-08" version="1" fragment="single">MNQNAAAVGDTWPDKLDMSLDDIIKLNKQQRNVKKALPLKGKQALNGSFPFKMQQKRSSSWRGIPQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH05</accession>
    <name>A0A401PH05_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epithelial membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0001986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PMP-22/EMP/MP20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000466">
        <property type="protein sequence ID" value="GCB72417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH05"/>
    <dbReference type="STRING" id="75743.A0A401PH05"/>
    <dbReference type="OMA" id="WHANTEY"/>
    <dbReference type="OrthoDB" id="6084046at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000026">
        <property type="entry name" value="Epithelial membrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004032">
        <property type="entry name" value="PMP22_EMP_MP20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF7">
        <property type="entry name" value="PERIPHERAL MYELIN PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01453">
        <property type="entry name" value="EPMEMFAMILY"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01221">
        <property type="entry name" value="PMP22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01222">
        <property type="entry name" value="PMP22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB72417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="159" mass="18227" checksum="06E7A123D8211125" modified="2019-05-08" version="1">MIVLLAGIVVLHLAVLVLLLISTVVNSWWYFNDSHSIDIWQNCTWNDFWNCESYTTNEWLQAVQAMMILSIIFSFLSVILFFCQLFTLQKGGRFYITGIFQLLAGICVMCGAAIYTVQYPHIHSEQYAGSYGFAYILAWIAFPLALCSGIIYVILRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH46</accession>
    <name>A0A401PH46_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0006313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002106">
        <property type="protein sequence ID" value="GCB72457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH46"/>
    <dbReference type="STRING" id="75743.A0A401PH46"/>
    <dbReference type="OMA" id="GLMQEFT"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06898">
        <property type="entry name" value="PX_SNX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043544">
        <property type="entry name" value="SNX10/11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46209">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46209:SF2">
        <property type="entry name" value="SORTING NEXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB72457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="19541" checksum="9C08895635B85F39" modified="2019-05-08" version="1">MDEPIKDKINEFITVWVRDPRIKKEDSWHSYVDYEICVHTNSMCFTKKTSCVRRRYREFAWLRQRLQDNAVLISLPEFPSKSPFFSANNGQHVEHRRQGLQEFLEKVLKINILLSDSRLHLFLQTQLDPTEIEACVSGSIESKELFRFKLRKHFILGAWKWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHA4</accession>
    <name>A0A401PHA4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0006343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002122">
        <property type="protein sequence ID" value="GCB72515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHA4"/>
    <dbReference type="STRING" id="75743.A0A401PHA4"/>
    <dbReference type="OMA" id="DKASXQT"/>
    <dbReference type="OrthoDB" id="10024684at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06967">
        <property type="entry name" value="NR_DBD_TR2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048245">
        <property type="entry name" value="NR2C1/2-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="180"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB72515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="359" mass="38572" checksum="60597FCF87751861" modified="2019-05-08" version="1" fragment="single">MAEVHMHQVSMAGSPPVSLAEQAQVKLITITDDLVQQLAEQQVSHSQGTLSTVAPGAVIGRPIMTSTPQRIQIVPADPGVTVAQRIQIVTDQQTGQKIQIVTSMDHGASKQFILTNSDGTSSNKVILARPDSGQGKVILATPDSAGLNQLIFTSPDGSAQHIQIVTDAVSGEQSAVKPPLEFCVVCGDRASGRHYGAVSCEGCKGFFKRSIRKNLVYLCRGSKDCVINKHHRNRCQYCRLQRCLALGMKQDSVQCERKPIEVSREKSANCAASTEKIYIRKDLRSPLAATPTFVTDKESARAFDTLAKALNPAEGQAVQNSAECMDTSGANIQLISGEQSLPVVEIEGPLLSDVHVAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHZ5</accession>
    <name>A0A401PHZ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0002173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000527">
        <property type="protein sequence ID" value="GCB72763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHZ5"/>
    <dbReference type="STRING" id="75743.A0A401PHZ5"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000008">
        <property type="entry name" value="Proliferation-associated 2G4, b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB72763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="395" mass="44176" checksum="8A0B2CDA0430D04B" modified="2019-05-08" version="1">MSDDESQEQTIAEDLVVTKYKMGGDIANRVLKMVVDAAKVGMSVVSLCEKGDEMIMEETGKIFKKEKEMKKGIAFPTCISVNNCVCHYSPLKSDPDYILKEEDLVKVDLGVHVDGFIANVAHTFIIGVNKDTPVSGRKADVVKAAHYCAEAALRLVKPGNQNTQVTVAWNKIAQSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKTAFEVHEVYAVDVLISTGEGKAKDAGQRTTVYKRDPTQQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKAKMGVMECAKHELLQPFNVLYEKEGEYVAQFKFTVLLMPNGPMRITSGTFENELYKSELDVKDPDLKALLQSSVSRRNQKRRKKKKVASQSALSATTGSTNEENEAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PII5</accession>
    <name>A0A401PII5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000555">
        <property type="protein sequence ID" value="GCB72950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PII5"/>
    <dbReference type="OMA" id="VLNWVRV"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052258">
        <property type="entry name" value="Diverse_Func_Domain-Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612:SF20">
        <property type="entry name" value="PER-HEXAMER REPEAT PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB72950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="368" mass="35413" checksum="6D417DFE18E28BE7" modified="2019-05-08" version="1">MRRFCHWLCSGSGSDTGSGSDTGSGSDTGSALALTLALALTLALALALTAPALALALTLAPALTLAPALALTLAPALTLAPTLALTQAQTLALVLTLALTLDLALTQALALALTLTLALTGSDTGSDSGLGTGSDTGSDSGSGSDTGTDSGSDTGSDSDSGSGSGSTLAWALTLTLALTGSDSDTALALALTLALTLHWLWPWHGSGSDTDSDTALALTLALTLALALTLALAPALTLALALVPALALALTGSGSGSDTGSSFDTALALTLAPALTLALALAPALALALTLAPALTLPLALALTLARALVLTLALTGYGSGSGSDTVLTLALTDSGSDTGSGSDTGSGSDTGSGSGSGSGSRWLWLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKE4</accession>
    <name>A0A401PKE4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000682">
        <property type="protein sequence ID" value="GCB73592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKE4"/>
    <dbReference type="STRING" id="75743.A0A401PKE4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="417" mass="40264" checksum="E89B69AE4F368C07" modified="2019-05-08" version="1">MRKCVSCVSVSVCPDVGVCPGVGVGPGVDVVPGVGVCPGVGVVPGVGVCPGVGVYPGVGVCPGVGVGPGVDVVPGVDVVPGVGVGPGIGVVPGVGVGPGVDVVPGADMVPGVGVGPGIGVVLVSMWSLVSMWSLVLMWSLVLVWVLVLVWSLVLVWVLVLVWSLVLVWVLVLVSWCCCRSRVDVGTGVGVGPSVCVGPGVGDVVVPGVGVAPDIVVSFGVGVGVLPGVGVDPGVSVVPAFGVAPNTVVSPGVDVGLFFGVGADVVPGVGAGVLPGVGMVPSVGAGVLPGAGVIPGVGAGVLPGAGVVLGVGACVLPGAGVVLGVGAGVLPGAGVLPGTGVLPGAGVLPGAGVFLVLVLVCFLVLVCILVLVCFLVLVLVCFPVLVLMWFLVLVKANYLKVIKTIFSPYFLKDYGYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKX3</accession>
    <name>A0A401PKX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0002829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000727">
        <property type="protein sequence ID" value="GCB73748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKX3"/>
    <dbReference type="STRING" id="75743.A0A401PKX3"/>
    <dbReference type="OrthoDB" id="44841at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF32">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="3">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="157" mass="17605" checksum="6551899B4B21F3C7" modified="2019-05-08" version="1">MTTAKTTVTSTINVPRQPKVYNTPINLYSSDNAHEVAEGQKRGLREGQSDAKQQNGSPRRYMASVQPDVHHHTLSDQSKKRLMQDTEDWQPKTGTAQSRSFCILAQMTGTEHLGGTTPASETNKKTRTKVTTIRYSPKYAQLRDWHHGVSARVLNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNC0</accession>
    <name>A0A401PNC0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001031">
        <property type="protein sequence ID" value="GCB74598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNC0"/>
    <dbReference type="STRING" id="75743.A0A401PNC0"/>
    <dbReference type="OMA" id="TIERITW"/>
    <dbReference type="OrthoDB" id="10072437at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053311">
        <property type="entry name" value="Mucosal_Integrity_Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37999">
        <property type="entry name" value="MUCIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37999:SF2">
        <property type="entry name" value="MUCIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019085477" evidence="1">
        <location>
            <begin position="27"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="374" mass="38377" checksum="2A0927D00F822FF2" modified="2019-05-08" version="1">MKSRSSSLALSKALIWNVLLESVAKALPESVATALPESVAEALPESVAEAPPENVAEAPPESVAEALPESVAEALPESVATALPESVVEALPESVAEALPESVAEALPESVAEAPPENVAEALPESVATALPESVVEAPPERVAEALPESVAEVLPESVATALPETVAEALPEIVMEALPETVAEAQPETVAEAQPESVAEALPENVMEALPETVAEALPESAAEALPESVAEALPESAAKALPESATEALPENVAEALPESVAGPCLRVRQRPCLRVWRKPCPRVCVVEALPESVVEALPESVVEALPDSVVEALPESVVEALPESVAEALPESVVEALPESVVEALPESVVEALPLLVSCDTPGGIATSPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PND7</accession>
    <name>A0A401PND7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0003716</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01001041">
        <property type="protein sequence ID" value="GCB74625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PND7"/>
    <dbReference type="STRING" id="75743.A0A401PND7"/>
    <dbReference type="OMA" id="VFKEVPM"/>
    <dbReference type="OrthoDB" id="115198at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF29">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB74625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="375" mass="43168" checksum="31A558553E6C5CBA" modified="2019-05-08" version="1">MQLIFCRLRTHQWCFLLFNVILFHALLFGADVVEEYLLQSSPTTYADTQTLDIRERARKLDMGPVKRNASEYFHISSAEACGDGDLFLLAVIASQAENLTQREVIRKTWANMSQVQGYGLLTLFAIGIPQTQAAQEEINREYENHRDIIQGTFLDSANNAIVKTTMIMRWTVTFCPKALFILKSDEETFVNYRSLMEYLLSLKRHAEDLYIGRVHHQVMPIRDPLSKYYVPVSLYSRKYYPDFCSSTAFVISQDVARKVFVVSMDMETSMPEDIFVGICAQKAGVVPIHSSRFSGEKHIRFNRCCYKFIFSSFGMTGDELVKAWEEINESRQCTMLDMYYGLIKCKALTYLDKLTSHRSTSHRSTESEELVASPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNN0</accession>
    <name>A0A401PNN0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein lifeguard 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0003772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001057">
        <property type="protein sequence ID" value="GCB74681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNN0"/>
    <dbReference type="OMA" id="YWFTYAL"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF47">
        <property type="entry name" value="TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB74681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="42093" checksum="BCF594DD85AE810D" modified="2019-05-08" version="1">MVTEIHHLEFIQLKVSKETKDKYVRKYDFETTDNVTKSHCKQKALFEPGVIRRKIQQRLEMDKTSRVNIMEQGAPAYGEYPYPPTQSLHPASPLGYSQGSHQQDYPPGYPSQEYPAPRYPPQNYSLQGQPANEPYQAFTGAPSESLDDAPPEYQDEFANETAQNFAEKVIRRAFIRKVYLTLMVQLLITIGIICMFLYWKTLNVWARKTYWFTYALFPALFVLIIILSCCDGFRRKTPWNFMLLFLFTIVEGLLLGAVSAVYGADAVMWAVGATIFVSVGLTLFSLQTKWDFTMGSGILFVALLVLMAFGILCAIIRSFYLVIDTQLMLGGKHRYSLSPEEYIFAALNLYLDIMNLFLFILQIIGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNS7</accession>
    <name>A0A401PNS7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Par3/HAL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0003875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001093">
        <property type="protein sequence ID" value="GCB74783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNS7"/>
    <dbReference type="STRING" id="75743.A0A401PNS7"/>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000017">
        <property type="entry name" value="partitioning defective 3 homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF10">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Par3/HAL N-terminal" evidence="5">
        <location>
            <begin position="98"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB74783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="232" mass="25304" checksum="3E324A19A06BC804" modified="2019-05-08" version="1" fragment="single">GSRPGSTPTNRNRWRQDRGAVYNPSRGPLATAHHGNHFVLRGQGRGGIKQKRQVCWTGEGKVLSLPVVSGLGLTLFISAPRREILWCVYILLLPRGVMKVTVCFARTRVVVPCGDGAITVHSLIQQAVTRYRRAIAKDPGYWVQVHRLEHSDGGILDLDDILSDVADDKDRLVAIFEEQEPHHGGDGTSASSTGTQSPEIFGNESAPNSLSAFQPYQASSEIEVTPSVLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP91</accession>
    <name>A0A401PP91_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Androgen-dependent TFPI-regulating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0020855</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017480">
        <property type="protein sequence ID" value="GCB74956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP91"/>
    <dbReference type="OMA" id="ANVMWHR"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF17">
        <property type="entry name" value="ANDROGEN-DEPENDENT TFPI-REGULATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB74956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11243" checksum="F6B0D7D69091C1FD" modified="2019-05-08" version="1" fragment="single">HTLVLPLILLELFNTPHQYPKRRIGLLILAIVSISYLLWVLWIYYAAGAWVYPLLGLFNRLGLVLFFSVSLLLVMILYLLGERLTLLTWGSAEKAKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRB9</accession>
    <name>A0A401PRB9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015107">
        <property type="protein sequence ID" value="GCB75660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRB9"/>
    <dbReference type="STRING" id="75743.A0A401PRB9"/>
    <dbReference type="OrthoDB" id="10013155at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026674">
        <property type="entry name" value="FLACC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21707">
        <property type="entry name" value="FLAGELLUM-ASSOCIATED COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21707:SF42">
        <property type="entry name" value="FLAGELLUM-ASSOCIATED COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="202" mass="23272" checksum="3C248B135D8E0244" modified="2019-05-08" version="1">MNDLLCPTENSLQRKCDEDKQSTIDNYEEQLSSVINKYHEEMEEAAKQYSSITDTIMELKNAKQEIKDLHEQLEQKIEELKNQAQYISFIESQLASDRAKLAEIEGTYKTNIGVMKRQYVVSIKALQDQNLDLKQLFAIKAEELCALKAAIEERERRDEIKMRMSVNQEHGRVFEMISPAVSDILQTQTPTPSQTEVNNPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT78</accession>
    <name>A0A401PT78_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein heavy chain linker domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0019123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013940">
        <property type="protein sequence ID" value="GCB76344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT78"/>
    <dbReference type="STRING" id="75743.A0A401PT78"/>
    <dbReference type="OMA" id="RTFPDQA"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="13">
        <location>
            <begin position="100"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB76344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="444" mass="52074" checksum="05866EFD048FB4D1" modified="2019-05-08" version="1" fragment="single">ELPEKWKNLKKIALTVKHEVAPLQSNEVAVIRRKYVQFEENQCKFREQFRNEAILRFNTHNPYTLLDKTHGNIIKLEAEMHSLQRTAELFEVNVPDYKQLKQCSLDIVLLKSVWDMVFFVQTSIDDWTKTQWKQINVEQMDMELRRFAKEMKTLDQEVRFWDVYAGLASMVKNMLTSLRAVTELQNPAVRTRHWQELMNATGVSFVMDADTTLGDLLALQLYRVEEEVKNVVDKAVKEMAIEKMLAEISQIWNVMELSYETHYSTGAPLLKSDENLIETLEDNQVQLQNILMSKYVEYFLADVSSWQKKLMISDLVISMWMEVQRTWAHLQSIFTGSEDIRNQLSEDAERFDEIDLNFKNLMAKIVKTRKVIETTNNLGLLEKLEVLQQRLMCCEKALAEYLETKRFTFPRFYFVSAMDLLEIISKGGQPKQVKIPLYTAHPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTY2</accession>
    <name>A0A401PTY2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011397">
        <property type="protein sequence ID" value="GCB76568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PTY2"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2096" mass="236217" checksum="2C47F06FB453701C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU14</accession>
    <name>A0A401PU14_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Serine/threonine-protein kinase SBK1</fullName>
            <ecNumber evidence="2 13">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">SH3 domain-binding kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0015517</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2 13"/>
    <dbReference type="EMBL" id="BFAA01008833">
        <property type="protein sequence ID" value="GCB76595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU14"/>
    <dbReference type="OMA" id="HETACKL"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13987">
        <property type="entry name" value="STKc_SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000337">
        <property type="entry name" value="Serine/threonine-protein kinase SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016234">
        <property type="entry name" value="Ser/Thr_kinase_Sbk1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF19">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000566">
        <property type="entry name" value="Ser/Thr_PK_Sbk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="34"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB76595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="385" mass="44013" checksum="716E0AA27E840709" modified="2019-05-08" version="1">MNSSLMTRGASDVLEELQLLTAQNLERLEVNKYYEVIRELGKGTYGKVDLVIHKVRGTKMALKFLRKKTTKLKSFLREYSISLYLSASPFIIDMFGIAFETDEYYVFAQEYATAGDLFDIIPPQVGLPEQIAKRCVHQVALALDYLHSRKLVHRDIKPENILIFDKECRKVKLSDFGMTRRAGTPVKRVSGTIPYTAPELCDASKHEGFSVDYSIDVWAFGVLLFCMLTGNFPWEKALLSDSFYDEFVRWQKRRGACVPSQWRRFTDDALRMFRKLLPVEPERRCSVKEIFRYLSYRWMLDTDCNNSIADVSSSSEEDLVARMKQQSLSPVCNIAKSAISVETPSSRFSSMTTSSSLSSNSSYERATRESNNTRILVATPIEICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUT6</accession>
    <name>A0A401PUT6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008886">
        <property type="protein sequence ID" value="GCB76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUT6"/>
    <dbReference type="STRING" id="75743.A0A401PUT6"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF12">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="27536" checksum="3510D70AAB5C48A6" modified="2019-05-08" version="1">MDFRTSSPGSHSSEVSYKPATKDWESYVRKNIKLMKSNAVREKVIWPRDSLFHYYELLEQLQYNLEERKKLQFLAVLPHRWAPLRAPGGNHGSLMWHQDSLIMNTDLWKAILVAKREKHRKLFLNYKSLCKFPPELLKDGGSEYLEHLYMKMNSLTTLPDNLGQKLPNLTELYLHSNNIAVVPEAIGTLVKLQSLDLSNNVLAILCPEIGQLKSLQHLRLANNQLRFLPSGEEITLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVK7</accession>
    <name>A0A401PVK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0015626</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008937">
        <property type="protein sequence ID" value="GCB77194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVK7"/>
    <dbReference type="STRING" id="75743.A0A401PVK7"/>
    <dbReference type="OMA" id="HVPEMMA"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20598">
        <property type="entry name" value="CYCLIN_CCNT2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20538">
        <property type="entry name" value="CYCLIN_CCNT_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000004">
        <property type="entry name" value="Cyclin T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000009">
        <property type="entry name" value="cyclin-T2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047322">
        <property type="entry name" value="CYCLIN_CCNT2_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="14">
        <location>
            <begin position="161"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
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        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB77194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="745" mass="82160" checksum="5041FE26F52FE1E3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVR5</accession>
    <name>A0A401PVR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of basal transcription 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015465">
        <property type="protein sequence ID" value="GCB77254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PVR5"/>
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    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ABT1/Esf2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="21113" checksum="5CA75B95BD5571AB" modified="2019-05-08" version="1" fragment="single">TRGSRGKKNGKRRGKSFTEGWVEFQNKAVAKRVAASLHNAPIGTRKRSRFHDDLWNIKYLHRFKWTHLSERLAYEKLVHRQRMRAEVSQAKRETNFFLQNVEKSKGLEKLQEVKKKKGQEWEEKHWHFQQRATETEIQASKAAGLRSKARELGTIAEHHRKSQSNVTLLAKIFNPSTAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW11</accession>
    <name>A0A401PW11_SCYTO</name>
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        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016780">
        <property type="protein sequence ID" value="GCB77282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PW11"/>
    <dbReference type="OMA" id="QICASED"/>
    <dbReference type="OrthoDB" id="10041077at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06713">
        <property type="entry name" value="PDZ_tamalin_CYTIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052122">
        <property type="entry name" value="Intracell_Traff_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963:SF1">
        <property type="entry name" value="CYTOHESIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963">
        <property type="entry name" value="GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="65"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB77282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="342" mass="38449" checksum="435A9BC66B8406B4" modified="2019-05-08" version="1">MAAKSSPSGYDSYSEISNRSFTDETDNKRLQMVASTLGTLPRGRRQLSLTRSNSLADTSYFQKKMVVLNKQDNETFGFEIQTHGIGQQNANALEMYTCVCKVHENSPSHVAGLKAGDMLVNINGVDTEGFSHQEIVDLIKSSGNLLSVLTINKDTAKRSELERKLHFLKKALQGKWVEYRSLMLQEQRLVHGLLRNNSTAEAADSLLYDNIAIFGSAMRNKERVSSDSSCRSQLSLMTDDSEDCDFQLSVFDDLAIGNHYRRSSMDEECFFHRETDMFTSKRQLSRSRSISVTSSGSGHKSPSWDSSCGTIPRKTRKSSVRKRLLKFIPGLNRAVEEDESHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW78</accession>
    <name>A0A401PW78_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015495">
        <property type="protein sequence ID" value="GCB77381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW78"/>
    <dbReference type="STRING" id="75743.A0A401PW78"/>
    <dbReference type="OMA" id="MQFITIV"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF5">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN MTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="6123" checksum="3B925D7DC34F4816" modified="2019-05-08" version="1" fragment="single">YVFFENSSSNPFLIRRIEELNKTVNGNVEAKCVCFYRRRDISSSLIALADKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYH7</accession>
    <name>A0A401PYH7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain containing 28A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018305">
        <property type="protein sequence ID" value="GCB78207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYH7"/>
    <dbReference type="STRING" id="75743.A0A401PYH7"/>
    <dbReference type="OMA" id="VEEQRNM"/>
    <dbReference type="OrthoDB" id="9977011at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400">
        <property type="entry name" value="CHEMOKINE C-C MOTIF RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 28A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14847" checksum="78F63188A703339A" modified="2019-05-08" version="1" fragment="single">RAVKEKPKLQSVAGKSTQSAPIQHSFLTDVSDVKNMERGLLSLLTDFHSGKLQAFGNECSIEQMEHVREMQEKLARLHFDLYSDLDEPEEEQGNVARDVHLDKLLTNLEELSSSIQKLNLADNQDVPRASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYY7</accession>
    <name>A0A401PYY7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0015821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009153">
        <property type="protein sequence ID" value="GCB78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYY7"/>
    <dbReference type="STRING" id="75743.A0A401PYY7"/>
    <dbReference type="OMA" id="DLEYTWG"/>
    <dbReference type="OrthoDB" id="9906386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901235">
        <property type="term" value="F:(R)-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022858">
        <property type="term" value="F:alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001761">
        <property type="term" value="F:beta-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015657">
        <property type="term" value="F:branched-chain amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015374">
        <property type="term" value="F:neutral, basic amino acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF286">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT NEUTRAL AND BASIC AMINO ACID TRANSPORTER B(0+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14742" checksum="B4DC2958FF1B7C18" modified="2019-05-08" version="1">MGKRDLALSVFSQNDHQTYSLEDTAVINGHVGESDENVERGNWSSKTEYLLSMIGYAVGLGNVCRFPYLAYRNGGGAFLIPYTLMLALTGIPMFFLESSFGQFASLGPVAVWKAVPMLQVDLEYTWGSSAIEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0E7</accession>
    <name>A0A401Q0E7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0020152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015854">
        <property type="protein sequence ID" value="GCB78861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0E7"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902176">
        <property type="term" value="P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="4">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="310" mass="32815" checksum="DE81AA48CF955608" modified="2019-05-08" version="1">MRCADKWLGKMNPEHYCKLNRVRHKHAGLNSEKLPLGTPIVMMILTKENAVKEWMELMGPVDHELAKASFPNSIRAQLDISISQNGFHSPSTVKLAKHHIMLFFGDAFLDSFGVHLEEELPISETPSVVPSTAAIESSDLVDVEAPTDEQQITTTEAPDEAPDATTEEGPEAGEAPDATTEEGPDTGEAPDATTEEVPEAGEAPDATTEEVPDTGEAPDATTEEVPEAGEAPDATTEEVPEAGEAPDATTEDVPDTGEAPDDTTEEVPEAGEAPDDTTEEVPEAGEAPDATTEEVPEAGEAPDDTTAPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1M7</accession>
    <name>A0A401Q1M7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0018724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013297">
        <property type="protein sequence ID" value="GCB79213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1M7"/>
    <dbReference type="STRING" id="75743.A0A401Q1M7"/>
    <dbReference type="OMA" id="IECKQAR"/>
    <dbReference type="OrthoDB" id="10060752at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1620.70:FF:000003">
        <property type="entry name" value="Collagen type XVIII alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045463">
        <property type="entry name" value="XV/XVIII_trimerization_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1096">
        <property type="entry name" value="COLLAGEN ALPHA-1(I) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20010">
        <property type="entry name" value="Collagen_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collagen type XV/XVIII trimerization" evidence="4">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Collagenase NC10/endostatin" evidence="3">
        <location>
            <begin position="287"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB79213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="357" mass="37251" checksum="4BCC844D729F1B33" modified="2019-05-08" version="1" fragment="single">GEKGEPGAVVAADGSLMAIRSKGQKGQPGPLGPPGPLGPMGHPGTKGEFGLPGRHGRPGINGRKGQKGEPTTTLLGPAGLPGPPGPPGPPGPILNIKGTVFPVPPRPHCKMPVNGQLEEQVDYNSLGLKGEKGSFGLLGPIGSKGEKGEQGTPGLPGPYSPYFGLKGEKGDSSAMGQKGEKGESGSGLFLSHSPGPPGPIGPHGRPGPVVRVFNNMELMHKSTYSVSEGSMGYITDRGDLYIRVYNGWRKLQLGDLIPAPADEPVRSFNAISASNTFPTINDQKPALHLVALNTPLSGNMRGIRGADLQCFQQARAMGSIATYRAFLSSQLQDLYTVVRKVDRLNMPIVNLKVSAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2Z1</accession>
    <name>A0A401Q2Z1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0016038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009440">
        <property type="protein sequence ID" value="GCB79789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2Z1"/>
    <dbReference type="STRING" id="75743.A0A401Q2Z1"/>
    <dbReference type="OMA" id="ALERWVH"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB79789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="323" mass="36012" checksum="20DDFE9641054D39" modified="2019-05-08" version="1" fragment="single">SLTSSPEDTEEARETSSGIEVEASDLSMSLTGDEQMAEEEEEADRRGSGDGGRRGTEKESSDERDSDSLEDTGTYSIVDEEEEEDEEEDESKMEHGRRETPARRRRGPKRPSEPERDSSEEEAALERWVHSEVAALPPPTWCAAPALGGREIGRDPRAFMYRACGARTFVERLRLQHGLERHTGCVNTLHFNRRGTWLASGSDDLKVVIWDWARRKPALEFDSGHKSNVFQAKFLPNSGDSTLAMCARDGQIRIAELSATECCKSTKRVAQHKGSAHKLALEPDSPCTFLSAGEDAVVFAIDLRQERPASIRLMNSHQHAERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3C9</accession>
    <name>A0A401Q3C9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Synergin gamma C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012132">
        <property type="protein sequence ID" value="GCB79929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3C9"/>
    <dbReference type="STRING" id="75743.A0A401Q3C9"/>
    <dbReference type="OMA" id="DIEIIWN"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039656">
        <property type="entry name" value="SYNRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059024">
        <property type="entry name" value="SYNRG_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463">
        <property type="entry name" value="AP1 GAMMA SUBUNIT BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463:SF2">
        <property type="entry name" value="SYNERGIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25999">
        <property type="entry name" value="SYNRG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Synergin gamma C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="208" mass="22455" checksum="2015A1791A007B34" modified="2019-05-08" version="1">MEAKVKTLQRCLNGIYKVIRTANDTLCAISKPSVCSEVLLSPQGTAYFSGVTEVYRVAKRVEGGMKTLSISNETLQHSLRDIEIIWNNLQAFLSFSPSMLRMLPAESTLDCSAVTASGNAQNETCGVCLLRTPNEPNDLNDTENSVLHNGCRYHASCANFWLNCVDSSLPGLIAPKENSETLDLEGLTVLGSNSLDTGPADLTVSTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3R0</accession>
    <name>A0A401Q3R0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0018852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013511">
        <property type="protein sequence ID" value="GCB79980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3R0"/>
    <dbReference type="STRING" id="75743.A0A401Q3R0"/>
    <dbReference type="OrthoDB" id="9838382at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057932">
        <property type="entry name" value="Spectrin_SYNE1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057933">
        <property type="entry name" value="SYNE3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25803">
        <property type="entry name" value="Spectrin_SYNE1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25804">
        <property type="entry name" value="SYNE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nesprin-1/3 spectrin repeats region" evidence="2">
        <location>
            <begin position="76"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Nesprin-3" evidence="3">
        <location>
            <begin position="291"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB79980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="400" mass="46386" checksum="FF51023247530F65" modified="2019-05-08" version="1">MGQRQELSGALSNKEGELDNLQAQAKAIIHNTSPKGAEHIIRDLEDLRADWDTLRLRCEQDQRSLELGLHSVLESQSRAEQLEREVADLQHRLHSLDVQPSDENESEAELRNCLIARSSILAEEPRVEEFHLKLKELCSFPQNEERLSAKVLSVIQEYKRVKGQIGKRCSQLGVSLRCSFQEVLRVFQQWRSSTRNLLHLSLDTKDGALVRTHLHNIKDHLVRSNQLEVQLDRFKRLEEMLRSIYGEEQAAAFESELKEAVQQRTFLTDGLLQRRRELQVNCQDPTDHKLLLKKFEEWLKNEDRKLANILAAEGPRSSKGTKNRKQGLKVLESRVPHGQKMFEKLIGAEFISMNEEEKKLEDLRYRWLVYKTKLKEAGELSVSTVMWIYRSSISLNDASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3S2</accession>
    <name>A0A401Q3S2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009500">
        <property type="protein sequence ID" value="GCB80018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3S2"/>
    <dbReference type="STRING" id="75743.A0A401Q3S2"/>
    <dbReference type="OMA" id="RESHNWI"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38556" checksum="F92B51A7B46899E8" modified="2019-05-08" version="1">MRPVGPRQLAVQALDAGGVCQVRPVGSKFDGSHVDRKNEAKKMPPERPDSLPTRMEDKEEKSERDQKSLELSKPSVPAIPPKKPMPPKTNSLNRPNTLPPKRPERPAAPTAHARSDSDPKSELGIPVVFLNTSERETLEKTNDIDVANFDSGVSSTEKLNHPTTSRPKASGRRPPSQVFTSPSLSSPDYLDSPISQEEDREEQERVELDSNTAKVKEIVKKAPRPIPVLPVSDKTLPPKPGAPNLPSGSNSHASAVYAFHHGITSAAGQRPNSPSQYNTDLKPKSDKTHDPIEELRAQMKELRSFIEMMKSQHKKEITQLMNELDEEKKIRISLQLEVEGIKKTLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4R8</accession>
    <name>A0A401Q4R8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0016178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009623">
        <property type="protein sequence ID" value="GCB80376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4R8"/>
    <dbReference type="STRING" id="75743.A0A401Q4R8"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337:SF3">
        <property type="entry name" value="MORC FAMILY CW-TYPE ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB80376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7769" checksum="4A666DEBE48EA06F" modified="2019-05-08" version="1">MAEKYHELSKAHLACDYLHANSTTHEFLFGALAELVDNARYGNQYHCQEPRHMNTQIFMITGKSLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6C2</accession>
    <name>A0A401Q6C2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0021744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019903">
        <property type="protein sequence ID" value="GCB80918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6C2"/>
    <dbReference type="STRING" id="75743.A0A401Q6C2"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045688">
        <property type="entry name" value="Ets1_N_flank"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF289">
        <property type="entry name" value="ETS-LIKE PROTEIN POINTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19525">
        <property type="entry name" value="Ets1_N_flank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="184"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="289" mass="32446" checksum="0295E4C39BB293E8" modified="2019-05-08" version="1" fragment="single">ETVEPSQCVPPSGYGESGFTSVSFQTLLPVSSEELYTLKSQCHYTALGQVDPGVHTDYLQVKQEAELADTFTGVTYPGGGTLSNRHQGNTHRHHSGTGVKVKTEHSFGLPDSPGSGDDIGLYWDRYLSIDTFTGLPSYQDATCEQRAQAPQHKGIYCRKGPGTLTESPASSRPVLTEYTGNGPIQLWQFLLELLLDKSCQSFISWTGDGWEFKLSDPNEVAKRWGNRKNKPKMNYEKLSRGLRYYYHRDIIYKTAGKRYVYRFASDMQTLLGETAQQLHARLDVKSRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q764</accession>
    <name>A0A401Q764_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022658">
        <property type="protein sequence ID" value="GCB81208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q764"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019518407" description="MAM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10244" checksum="E95AB92E5211A265" modified="2019-05-08" version="1">MLLATLLFLLLSPCHLLAISCNFETDLCEWGQNASNILQWIRDNGHDEKLPYQGPKYDHTLNGKGKQDGSRVQTRLCTGLKGASEEQSQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9P8</accession>
    <name>A0A401Q9P8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0022611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIMBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023201">
        <property type="protein sequence ID" value="GCB82047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9P8"/>
    <dbReference type="STRING" id="75743.A0A401Q9P8"/>
    <dbReference type="OMA" id="FNLKPCM"/>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000006">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000643">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF18">
        <property type="entry name" value="RIMS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB82047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="323" mass="36228" checksum="9860F6457C723E93" modified="2019-05-08" version="1" fragment="single">YNPYEGPNENPEAELPLKAGKYLYVYGDMDEDGFYEGELMDGRRGLVPSNFVALLQDEELFLFHSVDTEMDNNLLNSDVSHRGLQLPGDGVLRDSKTESLLPSHTEATMYNNGTGILDVNIDEIGEDIVPYPRKINLIKQLAKSVIIGWESAAVPPGWGTVNSYNVLVDKEVRSNVPFGGRTKALIEKLNLANVTYRISIQSVTDRGVSDELRCTLLVGRDVCVAPCHLKVDNITQMSAEVSWLPSNSNYSHMIFLNEEEYDMVKACSYKYQFFNLKPCMVCRMKAVAQPHQVPWQLPLEQREKKESVVEFCTLPAGLISPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBS5</accession>
    <name>A0A401QBS5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01035096">
        <property type="protein sequence ID" value="GCB82838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBS5"/>
    <dbReference type="STRING" id="75743.A0A401QBS5"/>
    <dbReference type="OMA" id="WISVEIN"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="3">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB82838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="88" mass="10428" checksum="880975AD88891CA8" modified="2019-05-08" version="1" fragment="single">MTSEEKRRTHQRELAHQLNEEAKRRLTENRGEQQSQRARKSRDSYKNPSQMPKESDIRGMKIYIDKKYETVILPVFGIATPFHIATIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBY8</accession>
    <name>A0A401QBY8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0024023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01037792">
        <property type="protein sequence ID" value="GCB82899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBY8"/>
    <dbReference type="STRING" id="75743.A0A401QBY8"/>
    <dbReference type="OMA" id="NLSIEMW"/>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF9">
        <property type="entry name" value="SI:DKEYP-117B8.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="9">
        <location>
            <begin position="572"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB82899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="75091" checksum="1F115D22A970784D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCP4</accession>
    <name>A0A401QCP4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034388">
        <property type="protein sequence ID" value="GCB83168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCP4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="62" mass="7191" checksum="BF153BF910D503F3" modified="2019-05-08" version="1" fragment="single">MGCARNWRGCDVRLTGEEDGRCSRLARRMGRALDWRGGWDVRLTGEEDGRCSQLARRMRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCP6</accession>
    <name>A0A401QCP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 11">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0023420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 11"/>
    <dbReference type="EMBL" id="BFAA01029178">
        <property type="protein sequence ID" value="GCB83159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCP6"/>
    <dbReference type="STRING" id="75743.A0A401QCP6"/>
    <dbReference type="OMA" id="CDNISIF"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000039">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="12">
        <location>
            <begin position="103"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB83159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="156" mass="18908" checksum="66B64857A1858514" modified="2019-05-08" version="1" fragment="single">SAEVIQSRLNEQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTLKEAVQKTSDQYMNELSEQPERKITRNQKRKHDEINHIQKTYAEMDPTTAALEKEHEAITKVKYVDKIQIGNYEIDAWYFSPFPEDYGKQPKLWVCEYCLKYMKFEKTYRFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDV6</accession>
    <name>A0A401QDV6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01045118">
        <property type="protein sequence ID" value="GCB83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDV6"/>
    <dbReference type="STRING" id="75743.A0A401QDV6"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="43" mass="4869" checksum="75A88C490DDF9BE1" modified="2019-05-08" version="1" fragment="single">AADDLRLLFANVQLEDGKKFSDYQIKDKSTILMVLRLPGGMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDY8</accession>
    <name>A0A401QDY8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01046618">
        <property type="protein sequence ID" value="GCB83574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDY8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="7441" checksum="F4F3D756F099166E" modified="2019-05-08" version="1" fragment="single">CGNYDSPTGEENAGTIAAIRNYENSDSQNCEEDGNPCSPETSAIRNCGNYGSPTGEENGNSVPAGTIAAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QED9</accession>
    <name>A0A401QED9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01041910">
        <property type="protein sequence ID" value="GCB83740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QED9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="39" mass="4353" checksum="947645678DF20E60" modified="2019-05-08" version="1" fragment="single">WCVAVVDDARRGYIQWTHTHYSGGGCRLHRSPGVPKTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF36</accession>
    <name>A0A401QF36_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Hexosyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0024526</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14389"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:134090"/>
            <dbReference type="EC" id="2.4.1.149"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with B3GNT8; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="EMBL" id="BFAA01048906">
        <property type="protein sequence ID" value="GCB83990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF36"/>
    <dbReference type="STRING" id="75743.A0A401QF36"/>
    <dbReference type="OMA" id="PCAYRSV"/>
    <dbReference type="OrthoDB" id="5957813at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008532">
        <property type="term" value="F:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030311">
        <property type="term" value="P:poly-N-acetyllactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000010">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF234">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB83990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="381" mass="43422" checksum="7E38D26F45551807" modified="2019-05-08" version="1">MNLTQKRCLLWTACSLLANLAIFWALWSRQWESGRRPQVPGAFWRADCPLQSLWNREERSLAQARAPATGQAGDRCLPDREVEGSFADFQHLPQQMKDFLLYRRCRAYPLLLEPRPVCQAAPRLLLAVKSQISSFARRQAIRQTWGGLGRASGVRLVFLLGQQWQGPPDGHPNLTGLLHCESRRHGDLLQWAFRDTFFNLTLKEVLFLGWLGRRCPGARYVFKGDDDVFVNTGRVLGYLAALGAREGRDLFLGDAIVDAVPARDSTLKYYVPGAFYRGLYPPYAGGAGVLYSGQLARRLARVSRGVPLFPIDDVYTGMCLRRLGLEPVHHPGFHSFGINATDRWDPCVYRRLFMVHRRSPREIVKLWRLLQQPNITCEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFP7</accession>
    <name>A0A401QFP7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0024635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01052105">
        <property type="protein sequence ID" value="GCB84147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFP7"/>
    <dbReference type="STRING" id="75743.A0A401QFP7"/>
    <dbReference type="OMA" id="VDCEDPR"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="45"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB84147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="23422" checksum="F89595BC28F01CB3" modified="2019-05-08" version="1" fragment="single">YGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPQASQGNVVSSLASGVPPPGNHPISGIPPAGAAVPWVDCEDPRSQIAPGTTCDGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGM1</accession>
    <name>A0A401QGM1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0025051</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01069294">
        <property type="protein sequence ID" value="GCB84529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGM1"/>
    <dbReference type="STRING" id="75743.A0A401QGM1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tudor-knot" evidence="14">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="45" mass="5361" checksum="C283F32F4C97090E" modified="2019-05-08" version="1" fragment="single">MEVIEGCRLPVLRRNQENEDEWPLAEILSVKDISGRKVFYVHYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGS9</accession>
    <name>A0A401QGS9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01069674">
        <property type="protein sequence ID" value="GCB84585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGS9"/>
    <dbReference type="STRING" id="75743.A0A401QGS9"/>
    <dbReference type="OrthoDB" id="1915767at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005131">
        <property type="term" value="F:growth hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060397">
        <property type="term" value="P:growth hormone receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF6">
        <property type="entry name" value="NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8605" checksum="38DB807ADF559E73" modified="2019-05-08" version="1" fragment="single">MNIYAGRFCEGEVEEEEEVDSSGGPCRSEARDIRVVLKVLDPSHRDIALAFFELASLMSQISHAHLAFVHGVCVRGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHD0</accession>
    <name>A0A401QHD0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01090513">
        <property type="protein sequence ID" value="GCB84784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHD0"/>
    <dbReference type="STRING" id="75743.A0A401QHD0"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16141" checksum="C67909315F3B2EA9" modified="2019-05-08" version="1" fragment="single">IKVILEQDTVIKVILQLGTVIKVTLELGTVIKVILELGTVIKVILELGTVIKVILGLGTVIKVILELDTVINVILELDTVIKVILELGTVIKVILELVTVIKLILELGTMINLILELGTVIKVILEQGTVIKVILELGTVFKVILELGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIZ1</accession>
    <name>A0A401QIZ1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01157449">
        <property type="protein sequence ID" value="GCB85342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIZ1"/>
    <dbReference type="STRING" id="75743.A0A401QIZ1"/>
    <dbReference type="OMA" id="HYRGSAD"/>
    <dbReference type="OrthoDB" id="4360948at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34147:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 WD40 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34147">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="309" mass="33334" checksum="01424B466ECD3039" modified="2019-05-08" version="1" fragment="single">KYRGSADVPVQYIGNADVPVQYRGSTVVPVQYRGSADVLVQYRGIADVPVQYRGSADVPAQYRGSSDAPVQNRGSADIPVQYRGSADVPVQYRGCADVQVQKRGSVDIKLQYLGSADISVQYRGSADVLVQYRGSADVPVGYRSSADVPVQYRGSTVGPVQYRGSADVRVQYRGNADVPVKYRGSADIPVQYRGNADVPVQYREIADVPVQYRGSTVVPVQYRGSADVVVHYRGSADVPVQYRGIADVPVQDIGSADVPVKYGGSAVQYIGNADVPVKYRGSADVPEQYRGNAHVPVKYRGSADVPAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJC3</accession>
    <name>A0A401QJC3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0026149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01164081">
        <property type="protein sequence ID" value="GCB85459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJC3"/>
    <dbReference type="STRING" id="75743.A0A401QJC3"/>
    <dbReference type="OMA" id="TMDATGN"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000010">
        <property type="entry name" value="Myosin regulatory light chain 2, atrial isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB85459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="206" mass="23274" checksum="5296F6EB78861392" modified="2019-05-08" version="1">MYQELSEITARRSKAEAKMNINTSPSQQGSRANMSSRKTKKNEGGAKRAQRASSNVFSSFEQTQIQEFKEAFTLIDQNRDGFIDKEDLKDTYASLGKLNVKDDELESMLHEATGPINFTVFFNLFGEKLHGSDPEEVMLNAFKMFDPDVKGHINKDELRQMLMTQADKFAAAEADQMFQSSPIDGAGNLDYKSLCYISTHSEEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLM9</accession>
    <name>A0A401QLM9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01272540">
        <property type="protein sequence ID" value="GCB86327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLM9"/>
    <dbReference type="OMA" id="GQRQMDR"/>
    <dbReference type="OrthoDB" id="8963449at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="284" mass="34971" checksum="B99378710690E34C" modified="2019-05-08" version="1" fragment="single">MDRWTETDGQRQMDRDRWTETDGQRQMDRGTDGQMDRDRSTETDRQRQMDTGRWTETDGQRQIDRDRWTEADGQRQMDRDRSTETGGQRQMDRDRSTETDGQRRMDRDRWTDGQRQMDRDRWAETDGQRQMDRDRSTETDGQRQMDRDRSTETDGQRQMDRDRRTGTDGQRQMDRDRCTETDGQRQMDRDRSTETDGQRQMDRDRWTETDGQRRMDRDRWTDGQRQMDRDRWAETDGPRQMDRDRWTEADGQRQTDRDRWTETEGQRQMDRDRWTDGQRQMDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLY5</accession>
    <name>A0A401QLY5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB86380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLY5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="40261" checksum="30B66AA210107239" modified="2019-05-08" version="1" fragment="single">IERERQTERETEREREKDRETDRERQRETERERDRERDRERDRDRERQRETERETERERETETERERQRERDREIQREIQRERQRERETETERERQRDTERETERERDRDRERETERETEIQRQRTTERDRERERDRDKERDRERETERDTERDTERDRERERQRQRERDRERDRERQTDRERETEREKERERQKKRQRDRDRDVRERQRDTETERYRDRQRDRERETERERDRQRETNRERQRETERQTQRDTERDRDRERDRERDRETERESDRERDRETETERDRERDRERETERETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMK0</accession>
    <name>A0A401QMK0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMK0"/>
    <dbReference type="STRING" id="75743.A0A401QMK0"/>
    <dbReference type="OMA" id="QWQTPAM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="171" mass="19361" checksum="1BEA73B4CA69BFBA" modified="2019-05-08" version="1">MADVSNGRQQQRQTSAMADISNGRRQQWQTPAMADVSNGRRQQWQTSATADISNGRRQQWQTSAMAVVSNGRRQQWQSSEMADVSNGRRQQWQTSEMADVSNGRHQQWQTPAMADVSNGRRQQRQTSAMAVVSNGRHQQRQTSATADVSNGRRQQRQTSEMADVSNGRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QML5</accession>
    <name>A0A401QML5_SCYTO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01317361">
        <property type="protein sequence ID" value="GCB86538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QML5"/>
    <dbReference type="STRING" id="75743.A0A401QML5"/>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23268">
        <property type="entry name" value="RIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10396" checksum="1693BFA3A0498165" modified="2019-05-08" version="1">MSEVFGSFSSPEKKLVRAVEERSRDRHTYLGGLVQDFLASLREGRGAQSSSSELLQSIRQFMTHVKMFLEHSSELDQTIEAFIEDKEEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QN54</accession>
    <name>A0A401QN54_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01366330">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QN54"/>
    <dbReference type="STRING" id="75743.A0A401QN54"/>
    <dbReference type="OMA" id="PHTVMIP"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="120" mass="12939" checksum="B0A393E58A6B5897" modified="2019-05-08" version="1" fragment="single">MSGCDPEPIIVPQCDPEPIIVSECDPEPIIVSECDPEPIIMSECDPEHIMMSGCDPEPIIVSECDPEPIIVSECDPEPIIVSECDPKPIIVSGCDPEPIIVSECDPELLIMSGCDPEPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNK8</accession>
    <name>A0A401QNK8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027674</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01382087">
        <property type="protein sequence ID" value="GCB86997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNK8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="10296" checksum="340A5EC61D73E571" modified="2019-05-08" version="1">MEGERERSERKEGERKRNETKEGERERNEIKEGERERNETKKGERERNKTKECERERNETMEGERERNERKEGKRDRNETKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPD2</accession>
    <name>A0A401QPD2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01409533">
        <property type="protein sequence ID" value="GCB87153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPD2"/>
    <dbReference type="OMA" id="CNWILVG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="139" mass="14233" checksum="88710428BAE75795" modified="2019-05-08" version="1" fragment="single">QSLAEALVLAEALVLVDALLLAEALVLAEALLLAEALLLAEALAPAEAQPLAEAKPLVEALAPAEALVLLEALLLAEALVLAEAQPLAEALVLLEALVLIEAPLLAEDLVLAEAQPLAEALRLAKAQALAETQPLIIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-05-20" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B1Q2V1</accession>
    <name>B1Q2V1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox-containing Dlx2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">StDlx2</name>
        <name evidence="11" type="ORF">scyTo_0021095</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Semin. Cell Dev. Biol." volume="24" first="110" last="118">
            <title>The Dlx genes as clues to vertebrate genomics and craniofacial evolution.</title>
            <authorList>
                <person name="Takechi M."/>
                <person name="Adachi N."/>
                <person name="Hirai T."/>
                <person name="Kuratani S."/>
                <person name="Kuraku S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the distal-less homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="AB293582">
        <property type="protein sequence ID" value="BAG14362.2"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAA01018089">
        <property type="protein sequence ID" value="GCB77340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B1Q2V1"/>
    <dbReference type="STRING" id="75743.B1Q2V1"/>
    <dbReference type="OMA" id="YSWYHQA"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000048">
        <property type="entry name" value="Distal-less homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022135">
        <property type="entry name" value="Distal-less_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF23">
        <property type="entry name" value="HOMEOBOX PROTEIN DLX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12413">
        <property type="entry name" value="DLL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="121"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAG14362.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB77340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="266" mass="29642" checksum="0A1580D6992B8569" modified="2013-03-06" version="2">MTGVFDSLAADMHSNQITSGYHTMHKSQESPNLPVSTATDSSYYNGQQQHGPCAGSPYGQLNSYQFHVGNMNNLSYSAKSYEISYSNCYSSYGPSNSPANTDVEKDCEPEIRVVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASMGLTQTQVKIWFQNRRSKFKKMWKNGEMSKEQNVIAGESPPCSSPPSSIAWDYSPHQRINNNSTITQNNGPPAAFIGNYSWYPGSNSASQFHSTPILQHQPTINPGAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGJ4</accession>
    <name>A0A401NGJ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0011018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004880">
        <property type="protein sequence ID" value="GCB59906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGJ4"/>
    <dbReference type="STRING" id="75743.A0A401NGJ4"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF36">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="72"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB59906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="205" mass="22834" checksum="D0AD062292020FCF" modified="2019-05-08" version="1">MLKKMNSSLGLPYSNFPLAEHLMKNNLSLYLPDAFLHEDLGNLENILLTIREPSTIALTVMYSISFAVGFVGNIMSIKVLTSKRNNRMTGVSATRSLLINLAVCDLMVVCVCMPTTLGYQIYKAWIYGDFMCRAAPFTQAVSVSASVLSITVISVNRVPSSEMRREEQQLEKISKIHFSAALSAYTPVTHMQARCLRKGRQFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGN7</accession>
    <name>A0A401NGN7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-Fucosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:82639"/>
            <dbReference type="ChEBI" id="CHEBI:90189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48293"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Golgi apparatus</location>
            <location evidence="1 6">Golgi stack membrane</location>
            <topology evidence="1 6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01004910">
        <property type="protein sequence ID" value="GCB60087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGN7"/>
    <dbReference type="STRING" id="75743.A0A401NGN7"/>
    <dbReference type="OMA" id="ATCHRIC"/>
    <dbReference type="OrthoDB" id="3226at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="360" mass="41602" checksum="16F962388D23C710" modified="2019-05-08" version="1">MVLLNKVRVCQRKKIQLFLTLLIGSITSVFINYKYQLGYGNIIARYLHSFENVTMTSRCERVNDSERVKISSKGIWTMNSIGRLGNQMGEYATLYALAKLNGHQAYILPAMANYLSPIFKITLPTLHDSVRNRIHWKGYNLNDWMEDQYRSIPGDYVMFSGYPCSWTFYHHIREEMLREFTFHDFLKEQANAFLRRITGERKNMTYVGVHVRRGDYVHVMPNVWKGVIADKKYLDTAMEYFRNKYKNVVFAVTSNGMDWSKENIDNSKGDVFFSDDPKQSSPADDIAILAHCNHTIMTVGTFGYWAGYLAGGETIYLTNFTLPESPFLKVFKYEAAFLPEWIGLPADLSPLLPKNDAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NL98</accession>
    <name>A0A401NL98_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">T-complex protein 11-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003809">
        <property type="protein sequence ID" value="GCB61644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NL98"/>
    <dbReference type="STRING" id="75743.A0A401NL98"/>
    <dbReference type="OMA" id="KTLEVIM"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46968" checksum="61E93354317BB27E" modified="2019-05-08" version="1">MPLEPGKPCGSGEEDTESTSHNRQDDSETEDLRNQLRQNPEISHSENTLTSVSPNLVSVEELIEAEKGICNMALAHEIVVDESFIIKQRDLPESSFEKTLEVIMKKAFWDSLRAQLNEDPPVYDHAIKLLGEIKESLLSFLLPGHTRLRNQINEVLDLELIKQEAENGALHIPKLADFIIGMMGTLCAPIRDDDIKNIRDITDVVELFREIFAVLDLMKLDMVNFAISSIRPHLMKQSVDYERKSFQEFFDKQHVYLVLPGIPPIQLFTWSALVMNSFNLAEAMVSMSEQICVEVNNCLSQHGFSLLIPEKETVLKGQIQAISRSDNSVRKLIDVRIQTFLKMHLVSCNPKSVAVPGGLGPVRSELEEITIKFLHLVNYNKLVFSPYYDTILTKELKKNGSQLPGPSEEEQLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NME1</accession>
    <name>A0A401NME1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Dynein heavy chain 5, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0004192</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001222">
        <property type="protein sequence ID" value="GCB62030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NME1"/>
    <dbReference type="OMA" id="TCKAYIY"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000543">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000009">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000010">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
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        <property type="entry name" value="Region D6 of dynein motor"/>
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        <property type="entry name" value="AAA_6"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR46532:SF13">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
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        <property type="entry name" value="Dynein_C"/>
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        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
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    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein axonemal heavy chain 2/5/8 coiled-coil" evidence="25">
        <location>
            <begin position="178"/>
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        </location>
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        <location>
            <begin position="362"/>
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        <location>
            <begin position="857"/>
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            <begin position="1341"/>
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        <location>
            <begin position="1836"/>
            <end position="2098"/>
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        <location>
            <begin position="2112"/>
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    </feature>
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        <location>
            <begin position="2485"/>
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            <begin position="2894"/>
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        <location>
            <begin position="3034"/>
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        <location>
            <begin position="3179"/>
            <end position="3485"/>
        </location>
    </feature>
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        <location>
            <begin position="2120"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2340"/>
            <end position="2388"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
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    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF25007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB62030.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3488" mass="397754" checksum="B8E15C183E297122" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMS0</accession>
    <name>A0A401NMS0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006496">
        <property type="protein sequence ID" value="GCB62152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB62152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17054" checksum="92E8B1DD2B416F29" modified="2019-05-08" version="1">MVLGTPTEETWPGVHSLPHLKTDRFPQYSSKNLRHAWNKLDYVAHAEDLASKLLQCFPKNRLSAPTALNHEYFSDLPPRLWELSDMSSVFTVPTVKLQAEIDTEEFLFLLPVQRLQVEVAVTSLPGQPAVQEPDADVTHKVNFITFDLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN40</accession>
    <name>A0A401NN40_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002567">
        <property type="protein sequence ID" value="GCB62318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401NN40"/>
    <dbReference type="OMA" id="HQGHGKT"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB62318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23180" checksum="16A427647E9AEFEA" modified="2019-05-08" version="1">MVICSTRIGFSIPGLGMLHPIILQRSGRTSGEKQRACAGDENAASGDKSADCFLAIHRLGKSSLTIQFVEGQFIDCYDPTIENTFNKTINFDGQDFYLQLVDTAGQDEYSIFSRSHTVDVHGYVLVYSVTSMKSFEVIKAIRSKLLDMVGKIQVVQTEEGKKLADSWGAAFLESSAKQNDTTVEIFKMMIQEIEKADGYTQDRRCDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNE8</accession>
    <name>A0A401NNE8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006531">
        <property type="protein sequence ID" value="GCB62428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNE8"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12573">
        <property type="entry name" value="AT09986P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12573:SF4">
        <property type="entry name" value="AT09986P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30260" checksum="468E8A8E1DFF3D80" modified="2019-05-08" version="1" fragment="single">AQSDLKNDSFQTAEIPESGLAPVTLHAHPQIGLQDYQTEMRAKENEIRELKQLIKSLKANHQQILELQKRFHSLHQEAVDLLIASACPPNLQEDLCNTEVKLAKKETLLQHLALASKQLDDESCIDKGVLKQMKLDYQTLKERILTFYQKQQEAQWRNLQEPQRNKANSNWQSMTLAQLIAPHSTAILVAVQEVPRVDGYGFTVRWRAGHGLKIVTAENSHLQPNDRLVEVNGMCVLNASEDKLMSLLTTPSAQILALRNPVPSAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNF5</accession>
    <name>A0A401NNF5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005221">
        <property type="protein sequence ID" value="GCB62425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNF5"/>
    <dbReference type="STRING" id="75743.A0A401NNF5"/>
    <dbReference type="OMA" id="ENTDREQ"/>
    <dbReference type="OrthoDB" id="2019614at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029131">
        <property type="entry name" value="HAUS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026215">
        <property type="entry name" value="HAUS5_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14817">
        <property type="entry name" value="HAUS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02091">
        <property type="entry name" value="HAUSAUGMINL5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="301" mass="34294" checksum="2C16D95C30F24162" modified="2019-05-08" version="1">MVIGKQEQKRRKLLEQLVSLRADIQQLDENTDREQQDIEEQALRETRERLQDLKDRNVLLKAFLQRAVSQRKSLQEQSKRVDDRLHVFRHIGSKADQGVGVGSASDGMLWCGSGQEPEVLQDVRGSCFTRFGLLKSLYDEQENVQGGNGDGGRDLRNASYHQWLNQIEGINATHPANHILAAMESLAAENKKELMELQSRVDVVKDMEALRFSYSSFHLQDVSEPPPVLRSVKSLLEDGWRDCEVRAVEKIGAIRRDKAMGSRLTLLSWEFKLLMEEQYGHDSVLLNAVRSDPTPLRSNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNL4</accession>
    <name>A0A401NNL4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0004247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001246">
        <property type="protein sequence ID" value="GCB62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNL4"/>
    <dbReference type="STRING" id="75743.A0A401NNL4"/>
    <dbReference type="OrthoDB" id="6589456at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13184">
        <property type="entry name" value="FERM_C_4_1_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17203">
        <property type="entry name" value="FERM_F1_EPB41L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000002">
        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030691">
        <property type="entry name" value="Band4.1-L3_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007477">
        <property type="entry name" value="SAB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF20">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04382">
        <property type="entry name" value="SAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002304">
        <property type="entry name" value="Membrane_skeletal_4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="110"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="849" mass="94761" checksum="33F63635CDDE0F1A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNW3</accession>
    <name>A0A401NNW3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0009552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003918">
        <property type="protein sequence ID" value="GCB62598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNW3"/>
    <dbReference type="STRING" id="75743.A0A401NNW3"/>
    <dbReference type="OMA" id="PHGLFEV"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="487" mass="53969" checksum="5F63545AC70F8B5B" modified="2019-05-08" version="1">MMMSGPGELPAVGNGAQYTVSEGDHVVLKREEVFKAVQVQSGRKITFEKQWFYLDNVIGQQYGTTFEVSTGGVLQPLKAKTEEVAKETNEAGIDNRNIIDDGKSQKLSRDDIEALKGQGLKGQDIVQHLIENSTTFRDKTGFAQEKYIKKKKKKYEAFITILKPTTRIMAMMYHSREPGKICYLRYDTLAQMLTLGNIHAGSKVIVAETCAGLVLGAVMERLGGFGSVVHLYPGSLPIRAAMENFGFPKSFYNHLYDFPINKLNSLLSGSFSTEKETLQKQTEVVVEEGNGSPLSTEQVVASCGETLMENIQSEETEAMDVACEDAENKEINAGKKTNVEERKSKQEDRMKKLQAAAAVLQGRNADGLIIASRLYPSPLLLCLLEFVAPSRPFVIYCQYKEPLLVCYSNLRERGGVVNLRLSETWLRGYQVLPNRTHPKLTMSGGGGYVLTGITVAMNKAKSIANNSKPQRLEEPAAKRQKVEESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPK4</accession>
    <name>A0A401NPK4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0004314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001270">
        <property type="protein sequence ID" value="GCB62803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPK4"/>
    <dbReference type="STRING" id="75743.A0A401NPK4"/>
    <dbReference type="OMA" id="YKGVYRV"/>
    <dbReference type="OrthoDB" id="10266706at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF32">
        <property type="entry name" value="HHIP-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="723"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="630"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="689"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="749"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="762"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB62803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="830" mass="93713" checksum="87A631E2683A494D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ27</accession>
    <name>A0A401NQ27_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide exchange factor DBS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0004332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001280">
        <property type="protein sequence ID" value="GCB62964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQ27"/>
    <dbReference type="STRING" id="75743.A0A401NQ27"/>
    <dbReference type="OMA" id="IYQFHSI"/>
    <dbReference type="OrthoDB" id="10004999at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF146">
        <property type="entry name" value="PROTO-ONCOGENE DBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="8">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="573"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="765"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="904"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="913"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1029" mass="117741" checksum="73709790E0042B53" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ96</accession>
    <name>A0A401NQ96_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EIPR1-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003967">
        <property type="protein sequence ID" value="GCB63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQ96"/>
    <dbReference type="STRING" id="75743.A0A401NQ96"/>
    <dbReference type="OMA" id="HQFLALH"/>
    <dbReference type="OrthoDB" id="196957at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060341">
        <property type="term" value="P:regulation of cellular localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000156">
        <property type="entry name" value="protein TSSC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="6">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="386" mass="43669" checksum="F6E84E285D9C541B" modified="2019-05-08" version="1">MEDDAPVIYGLEFQARALAPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQVGEIWHMSTSPADKGVLATCYNKTSDSKVLTCAAVWRMPKELESGSHESPDDSSSNPQTLELLCHLDNTAHGNMSCVLWEPMGDGKNIASLADNHILLWDLQESSSQAVLSNSATLEGKGQLEFTSGRWSPHHNCTQLATANDTYIRGWDTRTMSQVYCMENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVHEPVKTLEEHSHWIWSVRYNHSHDQLVLTASSDSRVILSNMVSISSEPFGHLVDDDDLSDQEDNHNEEKKEPLQDSIIATYEEHEDSVYAVEWSSADPWLFGSLSYDGRLVINRVPRALKYRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT71</accession>
    <name>A0A401NT71_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0011705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Golgi apparatus membrane</location>
            <topology evidence="2 15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01005418">
        <property type="protein sequence ID" value="GCB64081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT71"/>
    <dbReference type="STRING" id="75743.A0A401NT71"/>
    <dbReference type="OMA" id="WEFTRYH"/>
    <dbReference type="OrthoDB" id="9982049at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000088">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF130">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 15" id="KW-0430">Lectin</keyword>
    <keyword evidence="14 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="687"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="81"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB64081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="817" mass="92178" checksum="6153CD7F5E250E0C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUA2</accession>
    <name>A0A401NUA2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004104">
        <property type="protein sequence ID" value="GCB64471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUA2"/>
    <dbReference type="STRING" id="75743.A0A401NUA2"/>
    <dbReference type="OMA" id="HILHCTE"/>
    <dbReference type="OrthoDB" id="9938299at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="951"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1051" mass="121186" checksum="A3FD01AF61757379" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV55</accession>
    <name>A0A401NV55_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">VWFA and cache domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0000326</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May regulate voltage-dependent calcium channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel subunit alpha-2/delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000061">
        <property type="protein sequence ID" value="GCB64773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NV55"/>
    <dbReference type="OMA" id="RMQGDES"/>
    <dbReference type="OrthoDB" id="2150145at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000024">
        <property type="entry name" value="VWFA and cache domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000029">
        <property type="entry name" value="VWFA and cache domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000039">
        <property type="entry name" value="VWFA and cache domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF68">
        <property type="entry name" value="VWFA AND CACHE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="Sensory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="253"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1204"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1221"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB64773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1300" mass="144539" checksum="18B93283FB93A800" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVE4</accession>
    <name>A0A401NVE4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008104">
        <property type="protein sequence ID" value="GCB64845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVE4"/>
    <dbReference type="STRING" id="75743.A0A401NVE4"/>
    <dbReference type="OMA" id="YISAQHS"/>
    <dbReference type="OrthoDB" id="5963585at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029715">
        <property type="entry name" value="FAM35A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031589">
        <property type="entry name" value="SHLD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053944">
        <property type="entry name" value="SHLD2_OB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14495">
        <property type="entry name" value="SHIELDIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14495:SF2">
        <property type="entry name" value="SHIELDIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22779">
        <property type="entry name" value="OB_SHLD2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15793">
        <property type="entry name" value="SHLD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21669">
        <property type="entry name" value="SHLD2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shieldin complex subunit 2 first OB fold" evidence="3">
        <location>
            <begin position="448"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Shieldin complex subunit 2 second OB fold" evidence="4">
        <location>
            <begin position="610"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Shieldin complex subunit 2 C-terminal" evidence="2">
        <location>
            <begin position="750"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB64845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="916" mass="102326" checksum="4C7370C37BF505C9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVG7</accession>
    <name>A0A401NVG7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pseudouridine synthase</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0007597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Pseudouridine synthase that catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01002791">
        <property type="protein sequence ID" value="GCB64859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVG7"/>
    <dbReference type="STRING" id="75743.A0A401NVG7"/>
    <dbReference type="OMA" id="QTYCKGR"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000010">
        <property type="entry name" value="RNA pseudouridine synthase domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="9">
        <location>
            <begin position="163"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB64859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="481" mass="55054" checksum="64217FB2DE673D67" modified="2019-05-08" version="1">MSGAAGGDKRKEIEEEPGLGLQGNGQPPTKKPRNKKGKSGRYVPPPRKKNPGISFSHQHFRETQYYFENGLRKVFPYYFDFQTYCKGRWVGKTLREVFSSEFRVEPMEYYTQAAEAGRIRLNEEPADLNTVLKNNDFMRNTVHRHEPPVTAQPMEILTQNQEVVVVDKPASIPVHPCGRFRHNTIIFILGKEHGLTELHTIHRLDRLASGVLMFARTLEMSKKMDQQVRERQVQKEYVCRVQGEFPDGEITCEEPILIISYKVGVCRVDPSGKPCRTLFQKLSYNGTSSVVRCFPYTGRTHQIRVHLQYLGHPIVNDPVYNTEAWGPQRGKEGKVDKSNDELLKALVDVHRFKESLDLLDLPEEEHHCTMERGSIENTERSILPLNSQTEGTIDVKSEVAEEQVEKAADDKSVEVTKSTASELEEKPIVVKDTLCGECKLVRKDPSAKDLVMYLHALHYKGLDWEYSSMLPKWAAANWRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWB0</accession>
    <name>A0A401NWB0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0011840</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01005536">
        <property type="protein sequence ID" value="GCB65160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWB0"/>
    <dbReference type="STRING" id="75743.A0A401NWB0"/>
    <dbReference type="OMA" id="HANSHHD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000023">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000027">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000042">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF93">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019331683" description="protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="301"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB65160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="481" mass="54555" checksum="EBDD72A2A7B1E0A1" modified="2019-05-08" version="1">MTKWCILTLFLAVLSAAKAEETVATEEPSPPAEQDAEVVLTDEITEEQDVLVLHRYNFERALKENKYLLVEFYAPWCGHCKSLAPEYANAAGQLKNESSDLKLAKVDVIEEKELGSEFGIHSYPTLKFFKESDRKTPIDYTGKRNAKGIISWLKRRTGPSYAFLDSGAEVEKFIDSAEVVIVGFFKDLENDDVKTFAETANDVVEIPFAISNNVKILEKYDVSRNTIALFKKFDDRRADFEIEAETGLTKEELSKFIRINEMHLVTEFTQENNAKIFDAKIDNHILLFINKTIEEHNQILKKFQDAAASFRGKPYLKSEDIPEDWDKNPVKVLVGRNFEKVAFDETKNVFVEIYAPWCSHCKELAPIWDQLGEKYKDHENVLIAKMDATINEVESVPVEGFPTIKYFPAASGKKIINYEGARDLETFTTFLDNGGKLPQEAGADDNDELDIDDILNGETNKTTEQHPKGSDTASEAKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWD2</accession>
    <name>A0A401NWD2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004170">
        <property type="protein sequence ID" value="GCB65144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWD2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="297" mass="30997" checksum="861837D7245AA0AB" modified="2019-05-08" version="1">MCAGHRALLELDVVLGGNSKAMNVQELSVRETSAARQMKSVSDPTNAAVGMDTSEPTVRPNVLNGSGARTARRCVSATRTGAVPMRLASAPVTRTAGGQPAIDSVHANMGNATRIPASANASHAAGVPPVQTSATAAPTPSVIPKRASASARPAGGGAVATTSAPVTARHVTSWWGGVSARRNTGGTDVSGACVFTGNVTLPMDHARVILDTEEGTAGRRVQLDILASDVKKGLVEIFVCELYDESLSKDNGAIVHWLEIGCRTCDPFRLAYRSPDTGFIISHPSEFYNDNEMLMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWD5</accession>
    <name>A0A401NWD5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein EFR3 homolog A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein EFR3-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001420">
        <property type="protein sequence ID" value="GCB65177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWD5"/>
    <dbReference type="STRING" id="75743.A0A401NWD5"/>
    <dbReference type="OMA" id="QMCHANP"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000347">
        <property type="entry name" value="EFR3 homolog A (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF1">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB65177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="841" mass="95126" checksum="7C373B72C7565868" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWZ0</accession>
    <name>A0A401NWZ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001434">
        <property type="protein sequence ID" value="GCB65386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWZ0"/>
    <dbReference type="STRING" id="75743.A0A401NWZ0"/>
    <dbReference type="OMA" id="KLRHEYF"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF18">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="138"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="573" mass="65468" checksum="8D13EA0B8E5FC34F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX78</accession>
    <name>A0A401NX78_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 71</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0007725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002851">
        <property type="protein sequence ID" value="GCB65481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX78"/>
    <dbReference type="STRING" id="75743.A0A401NX78"/>
    <dbReference type="OMA" id="RISHLMS"/>
    <dbReference type="OrthoDB" id="8961338at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027975">
        <property type="entry name" value="TMEM71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35255">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35255:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15121">
        <property type="entry name" value="TMEM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31820" checksum="A004689898A8B4EE" modified="2019-05-08" version="1">MSTWLLKTGQQSKMYPASPYLSTQLPVAQIFPEDVQEEVSPKETLQSSRFSLMTNENSCSPWHRNPLSGSPCRCRRSPRLLMNGYYDLSEESFMDEEGNLTLTPSKINISYKENLVRIFRRKRRIRRSFASLFSIDSSSSWLNSSLFSGPDCPLAESSWVDGGSDFDSNFSINQGESSIDLSSTGKSWLSEETLPSINGEAYTGESLLMNKSTGGFLELPSHSQLHPAKCFFSNMPKNPGGFPHRYEANVVKTVNYSWRTCLVTRSREQVLISSCCLATFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXA7</accession>
    <name>A0A401NXA7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0007733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002855">
        <property type="protein sequence ID" value="GCB65511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXA7"/>
    <dbReference type="OrthoDB" id="9950693at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8344" checksum="32830EB223169D31" modified="2019-05-08" version="1">MWLHCSANVVEIPANEGGSLHRRAFYLLRTEGVRRLGTVTCRPVVHHIQERLGLCLCLCFVKTSCCAAVGTCVGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXP6</accession>
    <name>A0A401NXP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED20</name>
        <name evidence="7" type="ORF">scyTo_0000445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000085">
        <property type="protein sequence ID" value="GCB65634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_072336071.1">
        <property type="nucleotide sequence ID" value="XM_072479970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXP6"/>
    <dbReference type="STRING" id="75743.A0A401NXP6"/>
    <dbReference type="GeneID" id="140393684"/>
    <dbReference type="OMA" id="NIVMHHS"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="211" mass="23407" checksum="733603E2F36C85A7" modified="2019-05-08" version="1">MGVTCVSQIPAVEGKSVQQAVEMITKKLELLGAVKQGTFCVDCETYHAGQSVTVPGQAAKFMYVMHNTEFPLSCFALFENGPYLVADTNFDTLMIKLKGFFQNAKSSKIESRGSRYQYSDFLIKVGTVTMGPSVRGISVEVEYCPCIVSNDCWNLMMEFMQSFMGSHTPGIPSVFSTKHDGVYAPTDTVIQYMELFNKIRKQQQAPVSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYL8</accession>
    <name>A0A401NYL8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0004884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001473">
        <property type="protein sequence ID" value="GCB65978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYL8"/>
    <dbReference type="STRING" id="75743.A0A401NYL8"/>
    <dbReference type="OMA" id="ELNCENQ"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19442">
        <property type="entry name" value="CRBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB65978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="137" mass="15926" checksum="2DA781FE5288A368" modified="2019-05-08" version="1">MSTNFNGTWNIISNDNFDPYMQALDIDFATRKIAAMLSPQKIIEQKGDSFNIKTRSTFRNYEVQFTVGEEFEENTKGLDNRGCKSLVTWDNNKLVCVQKGEKENRGWTHWIEGDKLYLELNCENQVCKQVYKKVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2F4</accession>
    <name>A0A401P2F4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0013687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007095">
        <property type="protein sequence ID" value="GCB67315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2F4"/>
    <dbReference type="STRING" id="75743.A0A401P2F4"/>
    <dbReference type="OMA" id="ISADYTH"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000002">
        <property type="entry name" value="Conserved oligomeric Golgi complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1970:FF:000001">
        <property type="entry name" value="Conserved oligomeric Golgi complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 4 C-terminal" evidence="11">
        <location>
            <begin position="70"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB67315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="311" mass="35367" checksum="B3CD22BB7727C94E" modified="2019-05-08" version="1" fragment="single">TDSHVVKCCEMFLLFREVLYNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKQSFLVTLNNVEMCSENLLTLKKTLESDCTKLFSQGLGAELAQAKIDSCLSDLAAVSNKFKDLLQEGLAELNTTAIKPQIKPWITGFLSISHNIEEEEFNDYEANDPWVQQFILNLEQLMTEFKVGLSQVIYDSLTSLMTSLIAIELEKVVLKSTFSRLGGLQFDKELRSLIAYLTSVITWTIRDKFARLSQMATILNLERVTEILDYWGQNSGPLTWRLTPAEVRQVLALRNDFRSEDIKRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4D8</accession>
    <name>A0A401P4D8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sterol O-acyltransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Acyl-coenzyme A:cholesterol acyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cholesterol acyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0012214</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:64324"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:75121"/>
            <dbReference type="ChEBI" id="CHEBI:88768"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64325"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:64328"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:152049"/>
            <dbReference type="ChEBI" id="CHEBI:152050"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:64329"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:64320"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:84323"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:64321"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:42796"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:41509"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42797"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:42792"/>
            <dbReference type="ChEBI" id="CHEBI:3663"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42793"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>octadecanoyl-CoA + cholesterol = cholesteryl octadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:42812"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:82750"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:42813"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005833">
        <property type="protein sequence ID" value="GCB67991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4D8"/>
    <dbReference type="STRING" id="75743.A0A401P4D8"/>
    <dbReference type="OMA" id="TYDAYYR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034736">
        <property type="term" value="F:cholesterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF6">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB67991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="509" mass="59825" checksum="01D2227E6547A4E0" modified="2019-05-08" version="1" fragment="single">RIDAEHVISKKMQLKQKAEQMKTDLLKQFDFQFNHFVDNLIDESTTLDSTFSPSLSASVTKEQTAVAHGLTRAPPEKGKHFISRRSLLDELFQVNHIRTIYHMFIALLILFIVSTLVMDFIDEGRLVLDFDLLVYAFGRFPIVISTWLCMFLSTLLIPYGLFLQWASGYQASKHKVLRIVSFGALFLIFQMVGLWAAPVYTVIHFCLPPASRFIVILEQVRLMMKAHSFIRENVSRVLSNKEKNSGIQQIPQFSHYLYFLFAPTLIYRDSYPRNPTIRWSYVATKFAQVLGCLFYAYYIFVRLCIPLFRNISREPFSLKVLVLCIFNSILPGVLVLFLAFFAFLHCWLNAFAEMLQFADRMFYKDWWNSTSFANYYRTWNVVVHDWLYYYAYKDFLWLFTHRFRAAAMLSVFTVSAVVHEYVLAICFGFFYPVLFCLFMCFGMAFNFVLHDRRKGPVWNVIMWTSLFLGQGMLVCLYSQEWYAQQHCPLTNPSFLDLLKPRSWTCRLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4E7</accession>
    <name>A0A401P4E7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vasopressin receptor V2b-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0013763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Spawning by oviparous shark reveals the ancestral function of neurohypophysial hormones.</title>
            <authorList>
                <person name="Katayama Y."/>
                <person name="Inoue N."/>
                <person name="Kaiya H."/>
                <person name="Hyodo S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="12">Brain</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="LC440642">
        <property type="protein sequence ID" value="BBH84763.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAA01007171">
        <property type="protein sequence ID" value="GCB68002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4E7"/>
    <dbReference type="STRING" id="75743.A0A401P4E7"/>
    <dbReference type="OMA" id="QAICYPM"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045907">
        <property type="term" value="P:positive regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001992">
        <property type="term" value="P:regulation of systemic arterial blood pressure by vasopressin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF74">
        <property type="entry name" value="ARGININE VASOPRESSIN RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="57"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BBH84763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB68002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="360" mass="39974" checksum="179F0F5EBB601F1C" modified="2019-05-08" version="1">MSASLNVSANYNGVGTWHVLPNGTGTSDALGISQRDEQLAHAEIAVLAIIFAAATVGNSLLIGILCRRRRRGIRRMYVFLMHLSIADLAVAAFQVLPQLIWDITEVFLGPDVLCRAVAYLQLVGMFASTYLTVVMAVDRFQAVCYPMVTFQKSKGHWNTAICSSWILSLLLSLPQLFIFSKTEVAPGLLQCWAQFVQPWGLRAYVSWIFLVVFFIPAVVLTICQVRICRVIRLNIYTKTHQLTVHSRASNVNCISKAMNKTIKMAVVIVLAYVLCWAPYFTVQLCTAWYPSDTSEGAVFTILMLLGNLNSCTNPWIYMYFCGQIPRCTKHQPRCPVRNQSAVSTSVNLADKDAADASTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4W4</accession>
    <name>A0A401P4W4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Histone acetyltransferase</fullName>
            <ecNumber evidence="24">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">scyTo_0000830</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 24">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="24"/>
    <dbReference type="EMBL" id="BFAA01000172">
        <property type="protein sequence ID" value="GCB68157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4W4"/>
    <dbReference type="STRING" id="75743.A0A401P4W4"/>
    <dbReference type="OMA" id="EIGRYEM"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902035">
        <property type="term" value="P:positive regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000092">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="22" id="KW-0137">Centromere</keyword>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20 24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="26">
        <location>
            <begin position="335"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="23">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GCB68157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="614" mass="70832" checksum="9D5679531AB3F745" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P524</accession>
    <name>A0A401P524_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007197">
        <property type="protein sequence ID" value="GCB68232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P524"/>
    <dbReference type="STRING" id="75743.A0A401P524"/>
    <dbReference type="OMA" id="FLTINSH"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19689" checksum="7026772BD95B7D82" modified="2019-05-08" version="1">MSSVPISEEKEDKEEDSVHLEDSEMDEEEEATSIRAAGKKGHLARADSVQGAILRFLKSRTVPYAMKREVEEELERLQRLGLIEPIQISRWSAPIVPVLKNDGMEHTIIGYKLTINQVFKLEAYSLPRVEDAFSNLAGGMFSKLDMSQTYKKVLRKEDLKQYMTIDTWLVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P570</accession>
    <name>A0A401P570_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0005277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001625">
        <property type="protein sequence ID" value="GCB68253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P570"/>
    <dbReference type="STRING" id="75743.A0A401P570"/>
    <dbReference type="OMA" id="IFCLGAE"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034141">
        <property type="term" value="P:positive regulation of toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034145">
        <property type="term" value="P:positive regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000285">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF2">
        <property type="entry name" value="WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="281"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB68253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="410" mass="46163" checksum="DD8A2B9C98A04B78" modified="2019-05-08" version="1">MAAEIHSRMQTSRPVLLNKIEGHQDTVNAAVLIPKEDGVITVGEDRTIRVWLKRDSGQYWPSIFHTVSAPCTAISYNPDSKRIFIGQDNGAIVEFLMAEDFNKMTYVKTYPAHQNRISAVIFSPESEWVISTGHDKYLSWMCTRSGCLRGRHCFGAWASCLQYDVETSHAFVGDYSGQITLLKLEQNSCSIISALKGHEGSIGALWWDPVHRLLFSGASDHSIIMWDIGGMKGRTLLLQGHHDKVQSLCYLQLTRQLISCAADGGIVVWNMDVQREEAPQWQESDSCQNCKQPFFWNIKQMWDTKSLGLRQHHCRKCGKAICGKCSTKRTTYPVMGFEFQVRTCNECFDSVKEEDRTSLATFHEGKHNIAGMNLDNTRGLMVTCGSDRIVKIWDMTPVVGCSLATGFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P717</accession>
    <name>A0A401P717_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008577">
        <property type="protein sequence ID" value="GCB68893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P717"/>
    <dbReference type="STRING" id="75743.A0A401P717"/>
    <dbReference type="OMA" id="RMAYYLA"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="56744" checksum="7195D91F7A1F605F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7A4</accession>
    <name>A0A401P7A4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000203">
        <property type="protein sequence ID" value="GCB69017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7A4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB69017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="12993" checksum="D5AAF6337356E747" modified="2019-05-08" version="1">MELRESRKQRKRERKGQRQGAGEADPGAKMADLRTSDPAIQQALENMLQVIKSRCESLKRDNLDPLQKAVNQLNQRLDAQDEKVKELGEAVQELADAQTIDALEVDGLKERQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P822</accession>
    <name>A0A401P822_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0001020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000214">
        <property type="protein sequence ID" value="GCB69268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P822"/>
    <dbReference type="STRING" id="75743.A0A401P822"/>
    <dbReference type="OMA" id="SAGLCHK"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045703">
        <property type="entry name" value="POU2F1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000972">
        <property type="entry name" value="TF_octamer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF47">
        <property type="entry name" value="POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19536">
        <property type="entry name" value="POU2F1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00029">
        <property type="entry name" value="OCTAMER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="14">
        <location>
            <begin position="308"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="407"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="409"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="551"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB69268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="774" mass="80491" checksum="AF1F5F4009350C99" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8D9</accession>
    <name>A0A401P8D9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4683 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0001053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000220">
        <property type="protein sequence ID" value="GCB69407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P8D9"/>
    <dbReference type="OMA" id="CQPPEAN"/>
    <dbReference type="OrthoDB" id="9878678at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033629">
        <property type="term" value="P:negative regulation of cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000048">
        <property type="term" value="P:negative regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001953">
        <property type="term" value="P:negative regulation of cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001223">
        <property type="term" value="P:negative regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032757">
        <property type="entry name" value="DUF4683"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042794">
        <property type="entry name" value="Nexmif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46946">
        <property type="entry name" value="NEURITE EXTENSION AND MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46946:SF1">
        <property type="entry name" value="NEURITE EXTENSION AND MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15735">
        <property type="entry name" value="DUF4683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4683" evidence="4">
        <location>
            <begin position="268"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1331"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1371"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1403"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1417"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB69407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1446" mass="159390" checksum="1467AD16F8061F89" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8X1</accession>
    <name>A0A401P8X1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0005504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001721">
        <property type="protein sequence ID" value="GCB69589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8X1"/>
    <dbReference type="STRING" id="75743.A0A401P8X1"/>
    <dbReference type="OMA" id="EMDSEVR"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20447">
        <property type="entry name" value="Tudor_TDRD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="244"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="504" mass="56724" checksum="9DF2FA2B33162611" modified="2019-05-08" version="1">MQKGVRKYFGQKSLSEVTMDEYLSSQGLYRKLTAKDGSCLFRTVSEQEWAGVLEMNVLSLMYNCDFLIYRYPGKPPIQATNNGFGKKILLCCSNNGHYDSVFTKQFQGHAATCQAVVYEMLYRDVFGVDEEELRAAVELFRSHGKKTRRGSVSQGNDDAEYLSEKVLRKNDAENSDQESSPEEKTAKPGAEELKIADGPSKMPFPFKVLKALDSEIYRNVEFDVWLDSRKEQQKVDYMVVSGRHYCLGDKCQVKLEQGEKYYNAHIQEAGQDGNSVTVFIEELAEKHTVPLSNLKPVTQVTTVPAWNIVSNRKGGNYQKIPSGYVSELDLDPKSRRRFIKKIRGKQVFMAFAYGRGQSVLPPRLQHNLPSGRSSSLPSPQSGNFAHYDQYRVPPPPQRPGRNNYAPSSCYSRSRKPIQYVNKDCQFGYIAENEEPRANEEAVAFYEIEEGNEPNFPVVHNQSASSPILQAPAGYWVTRRGSPVSVGKQVNSSTEDADEPSDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P909</accession>
    <name>A0A401P909_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABTB2/3 histone-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004604">
        <property type="protein sequence ID" value="GCB69641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P909"/>
    <dbReference type="STRING" id="75743.A0A401P909"/>
    <dbReference type="OMA" id="WTESELQ"/>
    <dbReference type="OrthoDB" id="2316821at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22913">
        <property type="entry name" value="HFD_ABTB2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000057">
        <property type="entry name" value="ankyrin repeat and BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059008">
        <property type="entry name" value="ABTB2/3_histone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052089">
        <property type="entry name" value="Ankyrin-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46071">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46071:SF3">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26281">
        <property type="entry name" value="Histone_ABTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABTB2/3 histone-like" evidence="3">
        <location>
            <begin position="94"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="305" mass="34123" checksum="81EE82EAABAF9F18" modified="2019-05-08" version="1">MAALYNPSLKTLEDLTLDSGYGAGDSCRSLSLSSSRSNSQALQSTHRGNWWYLSGSMNSRNNSWDTVNTVLAEEPELTDIFFKCARLPELEEFPWTDEDIGKLLKRGRPGECGKPFSQEGVRRLSFLLRRVLLRVSREAQRLSVVHSKCTKFEIQSAIRLVLSWSLSESCISASVKALSLYNMSAGDRLRKSKSSRCCLTLSVGRFFRWMVDTRVSVRIHEYAAISLAACMESLLEEIGIRVAAGHGSEGVGLAMHDGRQELSMEMLEMCINNDAELWGILQPYEHLICGKNANGKERLTVKNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P964</accession>
    <name>A0A401P964_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0012462</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006028">
        <property type="protein sequence ID" value="GCB69669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P964"/>
    <dbReference type="OMA" id="FRCVIST"/>
    <dbReference type="OrthoDB" id="8691423at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052251">
        <property type="entry name" value="GH-ZnFinger_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057986">
        <property type="entry name" value="TPR_Rlf/292/654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058902">
        <property type="entry name" value="zf_C2H2_ZNF292/Rlf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15507">
        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15507:SF18">
        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25580">
        <property type="entry name" value="TPR_Rlf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25420">
        <property type="entry name" value="zf-C2H2_ZN292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26218">
        <property type="entry name" value="zf_C2H2_ZNF292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="648"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="719"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="748"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1269"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1477"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1529"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1564"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1605"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1171"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1391"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1704"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1768"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1888"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1968"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1396"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1413"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1712"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1768"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1995"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2025"/>
            <end position="2051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB69669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2207" mass="249863" checksum="A071D860F2464AA0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB15</accession>
    <name>A0A401PB15_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0005647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ILTIVWE"/>
    <dbReference type="OrthoDB" id="10063284at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="22949" checksum="AB79A2EFACE46DA6" modified="2019-05-08" version="1">MTKATKGKDENFILEILEMKNHYSEEKPKCKRDAKNLYHKLVKLEYAILTIVWEEVLERFNKTKLRENSADRIAYYESEAKALCEDITSSYSDASKRIVTKKFSDGTSGIASLRGADKFRIEVLHQLYDCLVIQLRKRIDPYEQIAKRFKFLSELVNNSEIDEDNIKLIISYSKDDIDHKLVNECYQFKEYLETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBR7</accession>
    <name>A0A401PBR7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000289">
        <property type="protein sequence ID" value="GCB70563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBR7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="GCB70563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8539" checksum="B8996EAB11CDCAAA" modified="2019-05-08" version="1">MWWLPLQLSPVQCKYKQPDVRTAAETAAAKPACEEREKNKTALHLEDLGEFNLLFLLYRPPTSYRNELDVKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE56</accession>
    <name>A0A401PE56_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Eyes absent homolog</fullName>
            <ecNumber evidence="15">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0001554</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01000356">
        <property type="protein sequence ID" value="GCB71404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE56"/>
    <dbReference type="STRING" id="75743.A0A401PE56"/>
    <dbReference type="OMA" id="CPLMESR"/>
    <dbReference type="OrthoDB" id="167668at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02601">
        <property type="entry name" value="HAD_Eya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12350:FF:000001">
        <property type="entry name" value="Eyes absent homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042577">
        <property type="entry name" value="EYA_dom_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF17">
        <property type="entry name" value="EYES ABSENT HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 15" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB71404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="504" mass="55560" checksum="D3939B366DE16415" modified="2019-05-08" version="1">MTILNTADWLLGCSTPASATMSLLAVKTEPMSSSDTATTTGDGSLDNYTGSVITSSGYSPRGIHQYSPQLYPSKPYPHILSTPAASTTDCPLMESRPKGDYRKHNLHCRLDALVTAQDLLHPSLAKRHIPIRCKVLVSHHHPVFMRAAILFPIRQASTILIRITLPIQHLAKTNPSNITGQPATDLPGGEFDTVQSPSTPVKDLDERTCRSSGSKSRGRGRKNNPSPPPDNDLERVFVWDLDETIIIFHSLLTGSYAQKYGKDPPIAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAATSANLCLATGVRGGVDWMRKLAFRYRRVKELYNTYKNNIGGLLGPAKRDAWLQLRAEVEALTDSWLSNALKSLSIISSRSNCVNVLVTTTQLVPALAKVLLYSLGGVFPIENIYSATKIGKESCFQRIVSKFGTKVTYVVIGDARDEEHAATQHNMPFWRISSHSDLLALNQALELEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFA5</accession>
    <name>A0A401PFA5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0001715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000396">
        <property type="protein sequence ID" value="GCB71830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PFA5"/>
    <dbReference type="OMA" id="WNQIRAM"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001143">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000015">
        <property type="entry name" value="Dynein heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000011">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF67">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1515"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1796"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB71830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2217" mass="253841" checksum="51A824DFCDEABEC5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFP4</accession>
    <name>A0A401PFP4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002005">
        <property type="protein sequence ID" value="GCB71946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFP4"/>
    <dbReference type="STRING" id="75743.A0A401PFP4"/>
    <dbReference type="OMA" id="FAQFYYI"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042411">
        <property type="entry name" value="WDR27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="83801" checksum="D6C4C01D7976D72C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFY5</accession>
    <name>A0A401PFY5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Netrin receptor UNC5A-D-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0009009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003573">
        <property type="protein sequence ID" value="GCB72042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFY5"/>
    <dbReference type="STRING" id="75743.A0A401PFY5"/>
    <dbReference type="OMA" id="CISHKIC"/>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000037">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Netrin receptor UNC5A-D-like N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB72042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="162" mass="18721" checksum="6DDA2AB5A8D1BE19" modified="2019-05-08" version="1" fragment="single">MQKHKEDDIFGELPEFFPSDPPEPLPHFLIEPRDAYIVKNKPVNLYCKATPATQIYFKCNSEWVHQKEHTTAEHVDDTSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSHKSYVRIAYLRKTFEQEPLGKEVSMEQEVLLQCRPPEGIPLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH30</accession>
    <name>A0A401PH30_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002089">
        <property type="protein sequence ID" value="GCB72394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH30"/>
    <dbReference type="STRING" id="75743.A0A401PH30"/>
    <dbReference type="OMA" id="IKPREFY"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12683">
        <property type="entry name" value="RRM_RBPMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000037">
        <property type="entry name" value="RNA-binding protein with multiple splicing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034787">
        <property type="entry name" value="RBPMS2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB72394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="226" mass="24609" checksum="CBD0B9BA11976CB0" modified="2019-05-08" version="1">MSTKSDEPNNNNEEEMPTDGLSPRDIQRYHRNPTPSDSRDKTSHFPSATPDLSNNDPDQVRTLFVSGLPMDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVTFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKNKLMATPNPTNMHPALGAHFIARDPYDLAGTGLIPASPEAWAPYPLYTTELTPGIPHAFTYPAAAAAAALHAQVTNGSCVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHL9</accession>
    <name>A0A401PHL9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein fem-1 homolog B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">FEM1-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0002101</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the fem-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000501">
        <property type="protein sequence ID" value="GCB72626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHL9"/>
    <dbReference type="STRING" id="75743.A0A401PHL9"/>
    <dbReference type="OMA" id="NMFTFLY"/>
    <dbReference type="OrthoDB" id="4429489at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140627">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000117">
        <property type="entry name" value="Protein fem-1 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF78">
        <property type="entry name" value="PROTEIN FEM-1 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="326"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB72626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="470" mass="52973" checksum="6B5B5C33D112F660" modified="2019-05-08" version="1" fragment="single">QVTSQPNEAPNHIRYLLEQHADPNAKAQCGATALHFAAEAGHLEIVKELVKWRATMVVNGHGMTPLKVAAESCKADVVELLLSHVDCDRRSRIEALELLGASFANDRENYDIEKTYHYLYLAMLERHRDPNNSMEKATLPSIEAYSGRTECKTLPELEAIRQDRDALHMEGLIVRERILGSDNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALCLRQKGNRNTHKDLLRFAQVFSQMIHLNEPVKARDVESVLKCSVLEIERGLSRIKDSSEVDIHAAMDNCESNIFTFLYLVCISTKTQCCEEERARINKQIYKLIHLDPRTREGSSLLHLAVNSGTPVDDFHTNDVCSFPSAQVTKLLLDCGADMNAVDKDGNGPLHIIVQYNRPISDFLTLHAIIISLVEAGAHADMTNKQKKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRVHNISYKSQIPQALEEFVEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHZ8</accession>
    <name>A0A401PHZ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0006440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002168">
        <property type="protein sequence ID" value="GCB72718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHZ8"/>
    <dbReference type="STRING" id="75743.A0A401PHZ8"/>
    <dbReference type="OMA" id="ECVISRE"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000063">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB72718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="23703" checksum="ECF6F141711E1301" modified="2019-05-08" version="1" fragment="single">MLRGLRSGIWALEAAAGPRSAPRLYSSQAESGLLCLQAYMGHWLDADGAALFRVTDPASGQQLLEVVNCGPREAREAVRAAHRSLASWKVATSKERSNLLRKWYDLMLKNKNELARLITAENGKPLKEALGETLYAASFLEWFSEEARRVYGDVVSTTSPDRRILILKQPIGVAAIITPWNFPSAMLTRKAGAALAVGCTVVVKPAEDTPLSALALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIM8</accession>
    <name>A0A401PIM8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Proton-coupled zinc antiporter SLC30A9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 30 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Zinc transporter 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0006567</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002229">
        <property type="protein sequence ID" value="GCB72982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIM8"/>
    <dbReference type="STRING" id="75743.A0A401PIM8"/>
    <dbReference type="OMA" id="GIQNLWT"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21078">
        <property type="entry name" value="NTD_ZNT9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000004">
        <property type="entry name" value="zinc transporter 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000002">
        <property type="entry name" value="zinc transporter 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="24">
        <location>
            <begin position="208"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB72982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="536" mass="59528" checksum="DFA57E014F293B58" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKE2</accession>
    <name>A0A401PKE2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000677">
        <property type="protein sequence ID" value="GCB73571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKE2"/>
    <dbReference type="STRING" id="75743.A0A401PKE2"/>
    <dbReference type="OrthoDB" id="2325980at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12160" checksum="2D8702F7E4895322" modified="2019-05-08" version="1" fragment="single">HIGLSSNMWVCNKNICALATWLSNFQGRWENSMVCASPEHTQGEDILDAVHGFQICSNLSATTTQITTGYTDSTQQSETTEYGTELMSTDSGSEDTENPTIETSAEDFLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKU5</accession>
    <name>A0A401PKU5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0002833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16190"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000728">
        <property type="protein sequence ID" value="GCB73752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKU5"/>
    <dbReference type="STRING" id="75743.A0A401PKU5"/>
    <dbReference type="OMA" id="ILNTEHY"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF10">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="172"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB73752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="425" mass="47525" checksum="30EF66D63004DD44" modified="2019-05-08" version="1">MAVPVQRLSHIAFHVGDGERLARDLIQRFRFQLFGSRVTERVRQLVLRRGSAVFMVNESPGGRRGEPGPRGLLYDVAPAQAVDSACNVSFEVRDVERAALLLERLGCQVLVPPRPVEDELGWVAYSVVRSVVGNVSHTLIQRSGYRGDFLPGFGPPPPAEQEAAGGPGAITHFDHITYACPPQQSAHILDWYRRCFGFQRFLLNRSDDLDDGYVIKGNNQGMRLSAMEYWKCSEVGMSMPAIEEKKVNCKLVLAESLPNPDKNQIDTFLEQHGGAGIQHVGLYTTDIISTCKSLTDAGVQFFYPPSGYYSETVKWQEIMKAGQDPEVLSHYGILLDSEVDDVHCKGETKCQASTERYLMQMFTKPIFCEETLFLELIERRNASGFGAGNIRALWKSVQACMDQRERNKIVKEISAGNRFANDVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKX7</accession>
    <name>A0A401PKX7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">REST corepressor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0002868</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CoREST family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000740">
        <property type="protein sequence ID" value="GCB73786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKX7"/>
    <dbReference type="STRING" id="75743.A0A401PKX7"/>
    <dbReference type="OMA" id="HFFVSYR"/>
    <dbReference type="OrthoDB" id="10064338at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1880:FF:000001">
        <property type="entry name" value="REST corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000033">
        <property type="entry name" value="REST corepressor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000002">
        <property type="entry name" value="REST corepressor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049048">
        <property type="entry name" value="REST_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF11">
        <property type="entry name" value="REST COREPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20878">
        <property type="entry name" value="REST_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="11">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="160"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="355"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB73786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51186" checksum="1064AEE7A1FB1F3F" modified="2019-05-08" version="1">MPTMIEKGPEVSGKRRGRNGAKSFPAAASSSSSSTSAAAAAAAAPPTPAVAAAVANGNNSWEEASSGSDEEHGGGMRVGSQYQAVVSDYDAEVAKHCQERENLGMLVWSPNQNISESKLDEYISIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDRVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQMKRDKEGSGDEIEESSANTTSVIDTEIEPSKEPKKEQGSQTVKSVPPKKETRTVQGKQRISQKPPRGMFLIQEDLDALSTSSGAAGTVLRQLDMELVSLKRQIQNVKQINGALKQKLDGGIEEFKPPEANQKINARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKTVVQVKNFFVNYRRRFNLEEVLQEWEAEHGSREENGSIADKPPNSPDVATKLSEEEEEAPSVLDVRYHSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLE6</accession>
    <name>A0A401PLE6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0003047</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01000801">
        <property type="protein sequence ID" value="GCB73964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PLE6"/>
    <dbReference type="OMA" id="QEDSHRD"/>
    <dbReference type="OrthoDB" id="10070999at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000457">
        <property type="entry name" value="Microtubule-associated serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF224">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="438"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="712"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="1015"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="917"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="978"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1100"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1154"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1297"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1557"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1689"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1787"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="917"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1154"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1173"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1189"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1567"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1690"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1714"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1799"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1813"/>
            <end position="1840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB73964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1869" mass="207260" checksum="F6766309DB395CBC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLV1</accession>
    <name>A0A401PLV1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0003203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <text evidence="10">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000857">
        <property type="protein sequence ID" value="GCB74116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLV1"/>
    <dbReference type="STRING" id="75743.A0A401PLV1"/>
    <dbReference type="OMA" id="HEMFLFG"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000105">
        <property type="entry name" value="Exportin for tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="11">
        <location>
            <begin position="99"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="12">
        <location>
            <begin position="321"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB74116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="962" mass="109673" checksum="6F19BA17E418FA53" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMS5</accession>
    <name>A0A401PMS5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-Fucosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0003471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:82639"/>
            <dbReference type="ChEBI" id="CHEBI:90189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48293"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Golgi apparatus</location>
            <location evidence="1 6">Golgi stack membrane</location>
            <topology evidence="1 6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01000947">
        <property type="protein sequence ID" value="GCB74381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMS5"/>
    <dbReference type="STRING" id="75743.A0A401PMS5"/>
    <dbReference type="OMA" id="NTSEFFP"/>
    <dbReference type="OrthoDB" id="3226at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF12">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB74381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="214" mass="24688" checksum="EA8A5BFACFA260B7" modified="2019-05-08" version="1">MEDQYRSIPGDFVMFSGYPCSWTFYHHIREEILHEFTFHDFLKEQTNTFLRRIRGEQKNVTYVGVHVRRGDYIHVMPNVWKGVIADKKYLDTAMAYFRNKYKNVVFVVTSNGMDWSKENIDNSKGDVFFSDDPKQSSPADDIAILAHCNHTIMTVGTFGYWVGYLAGGETIYLTNFTLPESPFLKLFKYEAAFLPEWIGLPADLSPLLPNGNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNK0</accession>
    <name>A0A401PNK0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0003779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001059">
        <property type="protein sequence ID" value="GCB74688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNK0"/>
    <dbReference type="STRING" id="75743.A0A401PNK0"/>
    <dbReference type="OMA" id="TCGSESQ"/>
    <dbReference type="OrthoDB" id="10009301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF47">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="130"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="244"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB74688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="525" mass="58666" checksum="824BF54D34E6452A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPL1</accession>
    <name>A0A401PPL1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal peptide peptidase-like 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017542">
        <property type="protein sequence ID" value="GCB75086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPL1"/>
    <dbReference type="OMA" id="CESFVAH"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF34">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16666" checksum="22345E30F257B5AF" modified="2019-05-08" version="1" fragment="single">NHESIMVEVAAGSGSTGEKLPVVIRVPRLVTSVATICGIPFSLLGFGDIIVPGLLVAYCRRFDLQTNTSNIYFISCTLAYAGGMFLTFIALILSKMAQPALLYLVPCTLITCSVVAWRRKEMQMFWAGNGYEVLDGTNETLTQDDECSWNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQZ3</accession>
    <name>A0A401PQZ3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008662">
        <property type="protein sequence ID" value="GCB75549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQZ3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="143" mass="16553" checksum="36D89C10DDD3D904" modified="2019-05-08" version="1">MGWSGLIKSEDNTPDQDSYEWNHLTIRTADWCPLFLMNQSGSLESYHHFSDTQLLNPGSRTVDFNSKPELTAQRQMEAECPTEETEQNIQKSDVAVSREYGVARYVTKITVNRNPWVTQISNGSYRKNTATYIWDEDSLWKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS88</accession>
    <name>A0A401PS88_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">MAP kinase-activated protein kinase 5</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0015406</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01008732">
        <property type="protein sequence ID" value="GCB75999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS88"/>
    <dbReference type="STRING" id="75743.A0A401PS88"/>
    <dbReference type="OMA" id="QVTKQAX"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090400">
        <property type="term" value="P:stress-induced premature senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14171">
        <property type="entry name" value="STKc_MAPKAPK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1170.10:FF:000002">
        <property type="entry name" value="MAP kinase-activated protein kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000179">
        <property type="entry name" value="MAP kinase-activated protein kinase 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000209">
        <property type="entry name" value="MAP kinase-activated protein kinase 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1170.10">
        <property type="entry name" value="MAP kinase activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027442">
        <property type="entry name" value="MAPKAPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB75999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="458" mass="52562" checksum="46C8C57766B6FFB0" modified="2019-05-08" version="1" fragment="single">ESSILDEYAINWTQKLGAGISGPVRVCMKKSTGERFALKILLDRPKARNEVRHHLMCVGHSNIVQIIEVYANSVQFPHESSPRPRLLIVMEMMEGGELFHRISQHKHFTEKMASQVTKQIALAIQHCHSLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDHGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISEMAKDIVRKLLKVKPEERLNIEGVLDHPWLNSTEALDNILPSSQMMMDKAMVAGIQQAHAEQLASMRIQDLKVSLKPLNSVNNPILRKRKLLGTRPKDGVYIHDPENEAEDANVALEKLRDVIAQCILPQAGENEDEKLNEVMQEAWKYNKDCKFLRDMLQSLSWNGRRFNDKVDRLKLAEMVKQVIEEQTNSQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSJ4</accession>
    <name>A0A401PSJ4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011312">
        <property type="protein sequence ID" value="GCB76109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSJ4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="51" mass="5619" checksum="9A1A9EBC99CCA97B" modified="2019-05-08" version="1" fragment="single">AVPFGFVLLEAVSTVKWQSPGTAANQLEKRANELSLKRHEESGCGHHFGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU40</accession>
    <name>A0A401PU40_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate decarboxylase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0016586</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17786"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010106">
        <property type="protein sequence ID" value="GCB76622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU40"/>
    <dbReference type="STRING" id="75743.A0A401PU40"/>
    <dbReference type="OMA" id="ANEICNS"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009449">
        <property type="term" value="P:gamma-aminobutyric acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF5">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB76622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="545" mass="61615" checksum="2DFD726CCCF868E7" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUF1</accession>
    <name>A0A401PUF1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iodothyronine deiodinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iodothyronine deiodinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014024">
        <property type="protein sequence ID" value="GCB76738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUF1"/>
    <dbReference type="STRING" id="75743.A0A401PUF1"/>
    <dbReference type="OMA" id="AYEIPKH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004800">
        <property type="term" value="F:thyroxine 5'-deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042403">
        <property type="term" value="P:thyroid hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000324">
        <property type="entry name" value="Iodothyronine deiodinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000643">
        <property type="entry name" value="Iodothyronine_deiodinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781">
        <property type="entry name" value="IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781:SF4">
        <property type="entry name" value="THYROXINE 5-DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00837">
        <property type="entry name" value="T4_deiodinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="1" id="KW-0893">Thyroid hormones biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="15163" checksum="CC2D69F7AEF9CE39" modified="2019-05-08" version="1">MTRLESFQRVVTQYADIADFLLVYIEEAHPSDGWVSTDAPYDIPKHRSLEDRLKAASLIDKENPGCLVVADAMDNSSNSAYGAYFERLYVVRNQKVVYQGGRGPEGYKISELRLWLEQYKNQSHDTSTVLIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUY4</accession>
    <name>A0A401PUY4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016695">
        <property type="protein sequence ID" value="GCB76954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUY4"/>
    <dbReference type="STRING" id="75743.A0A401PUY4"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="9033" checksum="C26A59D17A93E4FB" modified="2019-05-08" version="1">MVKNDDVGEELSVQRETPLPRRGAEPIMSARISSLTSALHSNVKNPKGKKWKGSHDQVKKPLKGKTSKAQRRKRTGKPGGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW08</accession>
    <name>A0A401PW08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011548">
        <property type="protein sequence ID" value="GCB77305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW08"/>
    <dbReference type="STRING" id="75743.A0A401PW08"/>
    <dbReference type="OMA" id="LCFQVQX"/>
    <dbReference type="OrthoDB" id="5988014at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB77305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="15034" checksum="D5B5C44184056B6A" modified="2019-05-08" version="1">MDGGVGSLLVVETDTFGSHVRIKGKETGHYICMSKRGKILGKLNGKSRECVFVEEVLENNYTALMSAKYKGWYLGFTRKGRPRKGSKTEQNQREVHFMKRHPKDKGEHHRPFKYTTVTKRTKRARHHKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW97</accession>
    <name>A0A401PW97_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014160">
        <property type="protein sequence ID" value="GCB77333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW97"/>
    <dbReference type="STRING" id="75743.A0A401PW97"/>
    <dbReference type="OrthoDB" id="9949358at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053282">
        <property type="entry name" value="RGS_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47079">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47079:SF1">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="128" mass="15117" checksum="23971F724D480827" modified="2019-05-08" version="1">MARIGLHDEFYEGLLRAKVEMIIKLFLQADTLPRLRVNITEFEKDKIVMSSRHGKLELGLFHQPRMNVFLPLIYLWKRFCVVNALRIYGTPRPLWKKEYNPPNYFYPCAQQAFQGLVPAFAAGKYWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYL9</accession>
    <name>A0A401PYL9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VASP tetramerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009125">
        <property type="protein sequence ID" value="GCB78208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYL9"/>
    <dbReference type="STRING" id="75743.A0A401PYL9"/>
    <dbReference type="OMA" id="CHSSATF"/>
    <dbReference type="OrthoDB" id="31170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005522">
        <property type="term" value="F:profilin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000004">
        <property type="entry name" value="Enah/Vasp-like, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF4">
        <property type="entry name" value="ENA_VASP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VASP tetramerisation" evidence="2">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="578" mass="60275" checksum="D0F2870158503BC3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZU8</accession>
    <name>A0A401PZU8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011821">
        <property type="protein sequence ID" value="GCB78638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZU8"/>
    <dbReference type="STRING" id="75743.A0A401PZU8"/>
    <dbReference type="OMA" id="LMQFNDM"/>
    <dbReference type="OrthoDB" id="2018023at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14316">
        <property type="entry name" value="UBA2_UBAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1920">
        <property type="entry name" value="UBAP1 SOUBA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049467">
        <property type="entry name" value="UBAP-1-like_UBA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038870">
        <property type="entry name" value="UBAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042575">
        <property type="entry name" value="UBAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960:SF5">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21267">
        <property type="entry name" value="UBAP-1_UBA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="78" mass="9421" checksum="0A1F4810A70E0818" modified="2019-05-08" version="1" fragment="single">ILKYLSAWDRLCKEGYKERLVEEAMEIFQNSEEKATEFLTLMTQFDEMGFQHEDIKEVLLVHNNHREKALEELMTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q102</accession>
    <name>A0A401Q102_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011910">
        <property type="protein sequence ID" value="GCB79036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q102"/>
    <dbReference type="STRING" id="75743.A0A401Q102"/>
    <dbReference type="OMA" id="HDISYMA"/>
    <dbReference type="OrthoDB" id="10027872at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005827">
        <property type="term" value="C:polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF5">
        <property type="entry name" value="KELCH-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="127" mass="14286" checksum="C0B21E875088318A" modified="2019-05-08" version="1">MAEEREVKQQSQKKVSQTYQSSAHSQSLLDGLVALRNSASLFDVTLIVEGKSIEAHRILLAASCDYFRGMFAGGLREMQEKEILLHDISYMAMCKILDFIYTSEMELNLNNVQDVLVAACQLQVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q175</accession>
    <name>A0A401Q175_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0020756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017239">
        <property type="protein sequence ID" value="GCB79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q175"/>
    <dbReference type="STRING" id="75743.A0A401Q175"/>
    <dbReference type="OMA" id="CITIVGS"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000016">
        <property type="entry name" value="Derlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="21491" checksum="5C908EAA8F6BC327" modified="2019-05-08" version="1">MAYQSLQQEYLQIPLVTRAYTTACVLTTAAVQLEIITPFQLYFNPELIFKHYQVWRLITNFLFFGTVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTIFGLFVNLVFLGQAFTIMLVYIWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLVSIYACCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1B0</accession>
    <name>A0A401Q1B0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Band 3 cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009314">
        <property type="protein sequence ID" value="GCB79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1B0"/>
    <dbReference type="STRING" id="75743.A0A401Q1B0"/>
    <dbReference type="OMA" id="PENETHD"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="2">
        <location>
            <begin position="145"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="240" mass="27781" checksum="D07E2FA79DB9613D" modified="2019-05-08" version="1">MVSNCKEPSCSYLVYSCEIWKEKYCKQIKEFDMKCQSANLKIDWQNKTKPPTLASPSQKEHARLRLAGEGAYESGHRTLYIGVHVPQGRRSHRRHRHRGHKHRKRDRERDSSTEDGRESPTYDTPSQRVQFILGTEDDDEEHIPHDLFTELDEICMHHGEDTEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCIINGTVLLDMRASTIEEISGIVANAQNIVGKLLFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1Y1</accession>
    <name>A0A401Q1Y1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017309">
        <property type="protein sequence ID" value="GCB79417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1Y1"/>
    <dbReference type="STRING" id="75743.A0A401Q1Y1"/>
    <dbReference type="OMA" id="HECCCLM"/>
    <dbReference type="OrthoDB" id="6250964at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047012">
        <property type="entry name" value="ICAM_VCAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771:SF9">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="107"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="229" mass="24932" checksum="DB866F4AB0DCC402" modified="2019-05-08" version="1" fragment="single">REINITSPPEVLEVNRTYSLECIGPRVYPNNKLILTWLRGNQTLQINSTGEQGFSDKDIRLRNVFSFTASVSDDGQEYTCLAEVDLGSNSTKPIANCSVTLQTHYEPIGTTVLANNKPISGESPVYFPNGGNIVLTCDSRGNPQPNVTWEYPVQNNVEITSRILYISVATTKNNGIYKCTATNKLGADETIVNVKIEDRRAIIAAASVSVVAAVALASGAIIYYLKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1Y9</accession>
    <name>A0A401Q1Y9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0019539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014645">
        <property type="protein sequence ID" value="GCB79402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1Y9"/>
    <dbReference type="STRING" id="75743.A0A401Q1Y9"/>
    <dbReference type="OMA" id="NCIFCFM"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000066">
        <property type="entry name" value="dynamin-binding protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF17">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
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    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="429" mass="47751" checksum="4739319AF19B76F8" modified="2019-05-08" version="1" fragment="single">VQDGMLLAVQNVHGLQRTLQDCDHGNADSLQELKNYQNSFESFKDHLERLVVMPLATLQVLFSAPQKLIQKRYDKLLDYVSCLKQSESVRDKRAAEELNEAKKDYEALNGQLVEELQAFNKAAKKILTNCIFCFMAVFSDLMTSALKASPAVKNILVPPSASVRVRQKQAIEEIHSLSFGKEFGSHRTIERRASLEERLKKRSPAPTPEAPHQTEENRAKLLATHSPDKLFQAKRNFNAAQDLDASLHEGEIVAVIEKQDPLGSVNRWLVETGMSQGYVYSSFLRPYIPVIGQNGVCTDGSVTDGDFDDISLFVSSHCGDGNNRSSLCLSTSDSDGPLTDSQEASPCTPETMSVDGNDGNSSDLGEQQIFYAVYPFQARSKHELSLQEYERVRIVKSSDLSGNADWWLAEVKGKRGYVPANYLGRMSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401Q2Q9_SCYTO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010702">
        <property type="protein sequence ID" value="GCB79646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="9237" checksum="A558164F0085278C" modified="2019-05-08" version="1" fragment="single">MLRRPSRDTSDPEQQMSPYSPNHKQLCNGGYQSPREEEDQRAVSACSKLSLFDKLTLSHNIWLQLGIEPACVKDVLGRQPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2U2</accession>
    <name>A0A401Q2U2_SCYTO</name>
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        <recommendedName>
            <fullName evidence="13">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161:SF2">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="10">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="403"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="760"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB79747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="83618" checksum="2E25014129D76F32" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q482</accession>
    <name>A0A401Q482_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013563">
        <property type="protein sequence ID" value="GCB80160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q482"/>
    <dbReference type="STRING" id="75743.A0A401Q482"/>
    <dbReference type="OrthoDB" id="8886722at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="242" mass="27966" checksum="8FA807FB3D795459" modified="2019-05-08" version="1" fragment="single">RSLSEAEGESAHWKGQCGRAQADCAELTLRHQETTDQLHISQGKLQRAENDNLWLRNLETKLEMVESEKQKLLDQISALKEDKDLKQEQLQTSQAKLQKMEEQKEMLASTISRLQEMVEKQTIQTTAQKKVMQQNDLFSARSEHRHQALQQQISELHDQLERQSALLHGKEKECSELHSELTHVQSEHQAWLEKLQLPRDQSKRFQKKPAQRRCCRCVALLLLGAAITGFAVLWANVDNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4A7</accession>
    <name>A0A401Q4A7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010836">
        <property type="protein sequence ID" value="GCB80203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4A7"/>
    <dbReference type="STRING" id="75743.A0A401Q4A7"/>
    <dbReference type="OMA" id="HQDVYLV"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF2">
        <property type="entry name" value="GLUCOSE-FRUCTOSE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="12594" checksum="1EE2408661DDB06F" modified="2019-05-08" version="1">MLPGVGVFGTSLTTRVIIPLLQSQGFPVKALWGRTPEEAEELAKEMDVPFYTNRIDDVLLHQDVDLVCINLPPPLTRQIAVKTLENVNTSGQEQKLKGPQNGMDAFPPNRTKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q660</accession>
    <name>A0A401Q660_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IF rod domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0023107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026321">
        <property type="protein sequence ID" value="GCB80853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q660"/>
    <dbReference type="STRING" id="75743.A0A401Q660"/>
    <dbReference type="OMA" id="VIVEICY"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF22">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="13333" checksum="268CEEAC7D5BBB3E" modified="2019-05-08" version="1">MKKNSGKHDDDLRVMKTEISDMQRQVGRINSEIQALNKQKEQLEAAIAEAEERGEIALVAAKKRIADLQEAIEKANKEMLRQVREYQDLMNTKLALDIEIATYKKLLEGEESRLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q720</accession>
    <name>A0A401Q720_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021336">
        <property type="protein sequence ID" value="GCB81166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q720"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8254" checksum="06B80879FCA9D20D" modified="2019-05-08" version="1" fragment="single">SFDSYIILTHYKCFLYDFDDVDSFGNASCPNMNSAACSSHLSTQFNKARNEIRERGDSSTTQFILRSNLDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7C4</accession>
    <name>A0A401Q7C4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025299">
        <property type="protein sequence ID" value="GCB81266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7C4"/>
    <dbReference type="STRING" id="75743.A0A401Q7C4"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="85" mass="9062" checksum="C9943B8785CB203E" modified="2019-05-08" version="1">MENGAESSLYRSDRTIMEESISVSAGSGRSLLLANIASTQMSLHAIYMHELHQQSAQPQCMGQGPQTHSSITEQPTAPGTLSPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7L7</accession>
    <name>A0A401Q7L7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022780">
        <property type="protein sequence ID" value="GCB81384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7L7"/>
    <dbReference type="STRING" id="75743.A0A401Q7L7"/>
    <dbReference type="OMA" id="NNSRHRC"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099631">
        <property type="term" value="C:postsynaptic endocytic zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="11655" checksum="91980CFABDCC376D" modified="2019-05-08" version="1" fragment="single">EIDADAYSAISQADQLQQEPESIRKWREEQIKHLAELDANSRETELEWREKAKKELEDWYIQQAEQLEEMKTNNRILDEAFYKQPFADVIGYVYVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7W0</accession>
    <name>A0A401Q7W0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018883">
        <property type="protein sequence ID" value="GCB81417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7W0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="17268" checksum="15BDF5636DD7A968" modified="2019-05-08" version="1" fragment="single">MPCSKGLEVILSCVSFRGLVTTIVDNNTEDMRKCLAVLTEVETKICDQLLEKLLCNVKIRLRDNLKDGRHSSLNNMEEVSSLIKSYFSNITEMNRATCKILVDRAHYKIVQEYITVLIHSSLRCTSESRYQIPEKIIQDSNELQHIFSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7X6</accession>
    <name>A0A401Q7X6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0021402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018910">
        <property type="protein sequence ID" value="GCB81466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7X6"/>
    <dbReference type="STRING" id="75743.A0A401Q7X6"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF177">
        <property type="entry name" value="CYTOCHROME P450 26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB81466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19475" checksum="C8368C58368ED871" modified="2019-05-08" version="1" fragment="single">FVLQHGDWRMFLEGFELVSAVATVTACLVSMMLLAAVSRQLWQFRWTVTRDRSCSLPIPKGSMGLPVIGETFHWLVEGSSFHSSRREKYGNVFKTHLLGRPLIRVTGSENVRKILMGEHTLVSSQWPRSTRMLLGSTSLINSIGDIHRHKRKVGYSKKTTAACALLKGHDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q875</accession>
    <name>A0A401Q875_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0023159</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family. Class-6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026815">
        <property type="protein sequence ID" value="GCB81584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q875"/>
    <dbReference type="STRING" id="75743.A0A401Q875"/>
    <dbReference type="OMA" id="VATEARC"/>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000051">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF68">
        <property type="entry name" value="POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB81584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15371" checksum="292BDF1ADFF636FF" modified="2019-05-08" version="1" fragment="single">FEKLDITPKSAQKIKPVLERWLTEAEIRHRAGIQNLTEFVGSEPSKKRKRRTSFTPQALEMLNAHFEKNTHPTGQEMTEIAEQLNYDREVVRVWFCNKRQTLKNTIKRLQQNDSTGTASAERISDSTVNTAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8A9</accession>
    <name>A0A401Q8A9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022918">
        <property type="protein sequence ID" value="GCB81606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8A9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16219" checksum="5CC14E638A44FA4D" modified="2019-05-08" version="1" fragment="single">METYDVRRKFVVHSPAFSGSKIQPSAAPPAKCVLCRAWSMRMEWSGSWRRANAPLVPVFMVTSPADQGSAHPSPVCTRAQTTEIVVCLVTNAHITSDSTATGRNSLTRTVRVRTVTVRMGQYAVPQLTALQSPAPDPRGRQVNAVQSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q958</accession>
    <name>A0A401Q958_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020466">
        <property type="protein sequence ID" value="GCB81910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q958"/>
    <dbReference type="STRING" id="75743.A0A401Q958"/>
    <dbReference type="OrthoDB" id="8964664at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="329" mass="36984" checksum="37F7A06802CA9BA3" modified="2019-05-08" version="1" fragment="single">FDTPMTRLEADFVQREAPPSYGQLIAQGLIPPVDDFPVYSPAQASVLQNIRTAMRRQIRRHATRRISSRGRLSRIWSRFFQRPRGWGLIPLLTPTSASTASSTHLGRSEIVRNCEQEENGRRYVQPQEDPDSDTDTETDRQVGDTPRATTVGWSVVTFQNTMPKASSSPSTDSQTELQMPSFLHSSSSEETCNTDFDFPFRQPSGDNCTNHDPLSGSPEWSFRRRRQRLRLGSRLLPIRARGTRGQGSVTVRITVLNSNFTSEPDHHRDPDHHRDPRQQSSTSAAPACRSQCSSCPESVSERPCSLPVPPHKHFCAETPSPDPSFQTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCI2</accession>
    <name>A0A401QCI2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01038115">
        <property type="protein sequence ID" value="GCB83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCI2"/>
    <dbReference type="STRING" id="75743.A0A401QCI2"/>
    <dbReference type="OMA" id="IAAGCGW"/>
    <dbReference type="OrthoDB" id="6380629at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="10986" checksum="0D991E1333FD673B" modified="2019-05-08" version="1" fragment="single">EHGDTGDQGSQGVGLPGFIGAQGSRGEHGKPGSGIPGQSGQQGPRGHTGQPGLRGYQGHRGPPGVCIAAGCGWNGVSSAPVPNTENQRPQPRRIPLPQNFIDQEEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEH2</accession>
    <name>A0A401QEH2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01039467">
        <property type="protein sequence ID" value="GCB83789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEH2"/>
    <dbReference type="OrthoDB" id="10664843at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="491" mass="54120" checksum="7C71207AF04A8154" modified="2019-05-08" version="1" fragment="single">ILALTNEQEKGLQCKPLCVCGYVNQQRSEIKIRDCVPASQFARAFALTVLSVRSLRNLLLDYLQLKNCVNMEQITHFEGFEETQERRDDNQARSADVEVSLNKVEPVAAFHSDVKQGDPESSLPEHRVKRQEQEVKGQLHVEAMEGGNSARKLDSTALKIETDLENADTDEEGDFIHGGMEAETKAECSEDIARFVPTCRRVVEIESAWQQQERECPRVLSLAVEQNAGGSGMVDDNKMEKVKNPNNAVPAPDEQLFEEKLLNVQRLQKEDDCKTAQSLGLVAPGEQNAQEGEVAPNPLVNEQKEAVEVLSEPAAGPPEDQIESVVKQSKEEATRQSFKGEGTDHTTGDSCQNNMGECLGEHTVTEQVAMGGGERRLERFLSQTELYITKADQQPSEESYSSDLLAPSCGDAVVCKLIPQYSTAVYSPEGRDCDQTEQGDGEFLLKKAMSAEEIGDVALEDGSERKSSASNIGEEAQTDNEMSSRDMGNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEU3</accession>
    <name>A0A401QEU3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-B-cell leukemia transcription factor-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0024610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01051300">
        <property type="protein sequence ID" value="GCB83938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEU3"/>
    <dbReference type="OMA" id="ERSEIWE"/>
    <dbReference type="OrthoDB" id="8947092at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051990">
        <property type="entry name" value="CCPG1/PBIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28638">
        <property type="entry name" value="CELL CYCLE PROGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28638:SF1">
        <property type="entry name" value="PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56487" checksum="C1326701532DCAEB" modified="2019-05-08" version="1">MLTDGNSFLPSCSPQGQKDELEGLLSAGNDRLPVESHENLKLLTQHLSEHLSHEESTLAALQGELRDLRQKIGAVEREGLGEADPRRGGRATGALVEERHVNRFLAQKENLVAEALMLRRELDKQRGIIASMREALEILIQRVSTLGGGLEAPTILEGLEEMEHKLAFELERSEIWETVYGTPKGEREKAKETRQASEQPELVGPTGGLGAPLPNVEAPRGAGETPARIPEAPPSNATPEAEFEALADSVKSTFVRLGEAAKGLWRASREEPPAAEGLPPGDQDQGLPGHKAWRRPEKRREGGRGGNGERGERTDSSDGKRGRKEWRKTPGGRKHFEKDGAAREGKRPKEAGKRWKRAGEKGQENGGKRQHHGHSKFWRKERALRAPKRRYRTPAGCTDVGSCAHKEGMDLFKVALEPVGADRFAALLEEYLRTSELGAAWADDLRGLAAPFFRDGVFIHDQVKFSDFVDDLEDYIEEIAEKVFGDDDAVEDFEDYIFRGLLGEAARKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH02</accession>
    <name>A0A401QH02_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0025254</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ena/VASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01079169">
        <property type="protein sequence ID" value="GCB84664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH02"/>
    <dbReference type="STRING" id="75743.A0A401QH02"/>
    <dbReference type="OMA" id="ANGMHHA"/>
    <dbReference type="OrthoDB" id="31170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005522">
        <property type="term" value="F:profilin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01207">
        <property type="entry name" value="EVH1_Ena_VASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000047">
        <property type="entry name" value="vasodilator-stimulated phosphoprotein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF12">
        <property type="entry name" value="VASODILATOR-STIMULATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="WH1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB84664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="151" mass="16755" checksum="775CD5DDB9CBEF8B" modified="2019-05-08" version="1" fragment="single">MGDPMALLRIVIGYVVQSSVYRAALVTLVSRFSETSICQARATVMLYDDANKKWVPAGTGPQVFSRVHIYHNPGNNTFRAVGRKMQPDQQVVINCAIAKGLKYNQATPSFHQWRDMRQVWGLNFGSKEDATLFANGMHHALEVLEGMASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHF7</accession>
    <name>A0A401QHF7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01093563">
        <property type="protein sequence ID" value="GCB84819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHF7"/>
    <dbReference type="STRING" id="75743.A0A401QHF7"/>
    <dbReference type="OMA" id="HRFIGKR"/>
    <dbReference type="OrthoDB" id="8958223at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="357" mass="39725" checksum="1D1817E6ED990ABD" modified="2019-05-08" version="1" fragment="single">RVSEHVSERVPDCVPEHIPDCVPEHIPDCVSERIPDCVSERVSEHVSERVPDCVPERAPEHVPDCVPEHVPDCVSERVSERVPEHVPDCVPEHVPEHVPGCVPDCVSERVSERVPEHVPEHVPDCVSESAPDCVSECVSEHAPDCVPDCVPDCVSEHVLERVPDRVPEHVPDCVPEHIPDCVPERVPDCVSESAPDCASECVSEHAPDCVPDCVSERVLERAPDRVPEHVPDCVPEHVSDCVPEPVPDCVPEPVPDCVSERAPERVPERVPERVPDRVPDCVPEHVPERVPEHVPDCVPQRVPEHVPERVPDCVPERVPERVPDRVPDRVPDRVPEHVPDCIPDRVPDCVPEHVPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ43</accession>
    <name>A0A401QJ43_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0026015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01149217">
        <property type="protein sequence ID" value="GCB85400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ43"/>
    <dbReference type="STRING" id="75743.A0A401QJ43"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB85400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="39" mass="4184" checksum="0D383794E136678A" modified="2019-05-08" version="1" fragment="single">MFVHGGSYMEGTGNMFEGSVLASYGNVIVVTINYRLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ81</accession>
    <name>A0A401QJ81_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0026028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01150664">
        <property type="protein sequence ID" value="GCB85409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ81"/>
    <dbReference type="STRING" id="75743.A0A401QJ81"/>
    <dbReference type="OMA" id="MQMASAC"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485:SF1">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB85409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="298" mass="33416" checksum="FB7C09B2245A3BDD" modified="2019-05-08" version="1" fragment="single">MNHSELSQSELSHSELSHSDLNHSELSQSELSHSELSQSELSQSELSHSELNHSELSQSELTHSELSQSELSHSELNHSELNHSELSQSELNNSELSQSELSHSELNHSELSHSDLNHSELNHSELSHSELNHSELSHPDLNHSELNHSELSQSELSYNELNHSELQSDLNDSELNHSELSHSELNHSELCQSELSQSELSQSELSHSELCQSELSQSELSHSELSQSELCQSELSHSELCQSELSHSELNHSELSHSDLNHSELNHSELNHSDLNHSELSHSEPSHSEPSQTELSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK68</accession>
    <name>A0A401QK68_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01191162">
        <property type="protein sequence ID" value="GCB85708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK68"/>
    <dbReference type="STRING" id="75743.A0A401QK68"/>
    <dbReference type="OMA" id="PREHERM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="12455" checksum="8CFFCC117A3E0B59" modified="2019-05-08" version="1">MELKMEEPRLDPRDHERAARDQWAEREREMERRERTRSEREWDRDKVKEYESKEGAKARSRSRSRSRDRRRKERAKSKEKRNEKKGAAPSSACPSSRQFHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK99</accession>
    <name>A0A401QK99_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01217637">
        <property type="protein sequence ID" value="GCB85841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK99"/>
    <dbReference type="OMA" id="PRVHTES"/>
    <dbReference type="OrthoDB" id="6142108at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="385" mass="40086" checksum="CCB72A46C779671D" modified="2019-05-08" version="1" fragment="single">TVREGSGLQSDTVREGSGLRSDAVRAGSGLRSDTVRKGSGLQSDTVREGSGLRSDTVQEGSGLRSDTVREGSGLQSDTVRKGSGLRSDTVREGSGLRSDTVREGSGLRSYAVREGSGLRSDAVRAGSGLRSDSVREGCGLRSDTVREGSGLQSDTVRAGSGLRSDTVREGSGLRSDTVRAGSGLRSYAVREGSGLRSDTVREGSGLRSDTVREGSGLRSDSVREGSGLRSDTVRDDSGLRSDTVREGSGLRSDTVRAGSGLRSYAVREGSGLRSDSVREGSGLRSDTVRAGSGLRSDAVREGSGLRSDTVRDGSGLRSDTVREGSGLRSDAVRQGSGLRSYAVREGSGLRSDAVREGSGLRSGTFRTTLVCGRTRFGRSLVCGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLM5</accession>
    <name>A0A401QLM5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01266915">
        <property type="protein sequence ID" value="GCB86280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLM5"/>
    <dbReference type="OMA" id="LWTTMDY"/>
    <dbReference type="OrthoDB" id="7870095at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="13696" checksum="037F8A30891E6112" modified="2019-05-08" version="1">MGRIMDPAVVMGGLRDPAVVMGGFWDPAVVQEGFRDPAVVKEGFRDPAVKEGFEDPDVVQGGIRDPAVVKEGFGDPAVVPKGFSDPAVVNEGFRDPAVVKQGFRDPAVVNEGFRVPAVVQEGFRDPASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMU9</accession>
    <name>A0A401QMU9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01318988">
        <property type="protein sequence ID" value="GCB86642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMU9"/>
    <dbReference type="STRING" id="75743.A0A401QMU9"/>
    <dbReference type="OMA" id="VIVVCYQ"/>
    <dbReference type="OrthoDB" id="9449914at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="264" mass="27685" checksum="DD8C9A561C677BF1" modified="2019-05-08" version="1" fragment="single">AVVQRDMGVAVAQRDMGVAAVQRDLGVPVLQRDLGVTVVQRDLGVAVVQRDLGIAAVQRELGVAVAQRDLGVAVVQRNLGVAVVQRDLGVTVVQRDLGVAVVQRDMGVAVVQMNLSVAVVQRDLGVAAVLRDLGVAVVQRDRGVVLVQRDLGVAAVQRHLDVAAVQRDLGIAVVQRDLGVVVLQRDLGVAVLQRDLGVAAVQRDLSVTVVKRDLGVAAVLRDLGVAVVQRDLGIVVVQMDVGVAAVQRDLGVAAVQRDLGFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNR8</accession>
    <name>A0A401QNR8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01400123">
        <property type="protein sequence ID" value="GCB87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNR8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="10218" checksum="A17C281828B55120" modified="2019-05-08" version="1">MKEGERERNETKKGERDRNETKDGERERNEMKEGESERHETKEGGRERNETWEGETERHETKEGERERSKTKEGERDRHEMKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPD5</accession>
    <name>A0A401QPD5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0027927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01433267">
        <property type="protein sequence ID" value="GCB87236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPD5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB87236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="181" mass="18517" checksum="49B903437C03C8AA" modified="2019-05-08" version="1" fragment="single">WAAAERAVAERAAVERAAVERAAAERAAAEWAAAERAAAERAAAEWAAAERAAAEWAAAERAAAEWAAAERAAAEWAAVEQAAAERAAAERAAAERAAVERAAVERAAAERAAAEWAAAERAAVERAAAERAAAERAAAERAAEERAAAERAAAERAAVEGAAAERAAAERAAAEWAAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPI0</accession>
    <name>A0A401QPI0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01435911">
        <property type="protein sequence ID" value="GCB87242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPI0"/>
    <dbReference type="STRING" id="75743.A0A401QPI0"/>
    <dbReference type="OMA" id="RVSCKVI"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="179" mass="18997" checksum="07B5C92D1DC0FE7A" modified="2019-05-08" version="1" fragment="single">DLSDAIVVDLTDVIVLDRTDVIVVDLTDAIVVDLTDAIVVDLTDAIVVDLTDVIVVDITDAIFVDLTDVIVVDITDVIVVDLTDAIVVDLTDVIVLDLTDVMVVDLTDVIAVDLTNVIVVDLTDAIVVDLTDVIVVDLTDVIVVDLTNVIVVNLTDAIVVDLTDVIVVDLTDAIVVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPN4</accession>
    <name>A0A401QPN4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01440566">
        <property type="protein sequence ID" value="GCB87288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPN4"/>
    <dbReference type="STRING" id="75743.A0A401QPN4"/>
    <dbReference type="OMA" id="HTVKFRH"/>
    <dbReference type="OrthoDB" id="7454467at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="19447" checksum="A276D8633D7D730D" modified="2019-05-08" version="1" fragment="single">RHVASERHAASERHAASERHVASERHAASERHVASDRHAASERHAASERHVASERHAASERHAASEHHVASERHAASERHAASERHAASERHAASERHAASERHAAGERHAAGERHAASERHVASEWHVASERHAASERHVASERHAASERHVASERHVASERHAASERHAASERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGW0</accession>
    <name>A0A401NGW0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor Spi-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0009113</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds DNA as a monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003633">
        <property type="protein sequence ID" value="GCB60105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGW0"/>
    <dbReference type="STRING" id="75743.A0A401NGW0"/>
    <dbReference type="OrthoDB" id="10043646at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000335">
        <property type="entry name" value="Spi-C transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF174">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPI-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ETS" evidence="11">
        <location>
            <begin position="113"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="217" mass="25664" checksum="81AAF1A4BA5305D9" modified="2019-05-08" version="1">MNPVAEDLEVIMEFLDEQQHAFVFEKETSSVSGACAFGLPLENWQPSSDMNRNPTYQEIHLPLQRYTFNPCGHSINADCVYYPCYSPLPDFSPTLPPDYMIRGFNSDKRKRKVRLFQFLFEMLEDPGMRHCIWWIQPFRGLFQFSSQNKEKLAEIWGRRKGNRKTMTYQKMARALRNYSRTGEITKVKRKLTYQFNQQVINRLQGGSRRSFNYSLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHA4</accession>
    <name>A0A401NHA4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein furry C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003652">
        <property type="protein sequence ID" value="GCB60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHA4"/>
    <dbReference type="STRING" id="75743.A0A401NHA4"/>
    <dbReference type="OMA" id="PLYIEST"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045842">
        <property type="entry name" value="Fry_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF29">
        <property type="entry name" value="PROTEIN FURRY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19421">
        <property type="entry name" value="Fry_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein furry C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="319" mass="35900" checksum="CBD99D0A5F96335E" modified="2019-05-08" version="1">MSDSDGSCAVHTFHVFSSLFQCIRKKFCSLTWDAASFLGDSLRGIGSKFMSSSEVLTSCSDCPTVFLDAETLISCGLLERLKFNVLELQEYLDTYNHKSEAAQLWLANCKASFPGTMGDTVITNQPGDLEEKQLELCQRLYKLHFQLLLLFQSYYKLIGQIHVVNSVPELLNMSKELNDLRDNLKEASALIAVEPLKDEFSSHGLTVTSSEIAVQTMLECLKNRDLITALRQIRDCRTIWPNDIFGSNVEDEVQTLLNLYFRHQTLGQTGTFALLGSNHDLSEISSKLMELNGEIQDMIQKAQSYRVISTYFPDTSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIK9</accession>
    <name>A0A401NIK9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002418">
        <property type="protein sequence ID" value="GCB60706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIK9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8246" checksum="B144E19310C448A7" modified="2019-05-08" version="1">MRHLPSLKHSPSRAKRTITKMEQFFMITFPLYGTGKAANELIHMASALEQLPNVTAAEARELDRHWLRAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIM6</accession>
    <name>A0A401NIM6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline and serine rich 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006295">
        <property type="protein sequence ID" value="GCB60732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIM6"/>
    <dbReference type="STRING" id="75743.A0A401NIM6"/>
    <dbReference type="OMA" id="SPPGFFW"/>
    <dbReference type="OrthoDB" id="9944770at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037646">
        <property type="entry name" value="PROSER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22045">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22045:SF6">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="80421" checksum="5BD07A76BEED225A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK53</accession>
    <name>A0A401NK53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein unc-93 homolog A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0014307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007626">
        <property type="protein sequence ID" value="GCB61253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK53"/>
    <dbReference type="STRING" id="75743.A0A401NK53"/>
    <dbReference type="OMA" id="CLWGMAD"/>
    <dbReference type="OrthoDB" id="78663at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB61253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="21823" checksum="BF0E06FDC3155BC4" modified="2019-05-08" version="1">MSTIHTLSGIYTGVGVAGVILVAFFLDQFDQDDVKQFKEKDINLLSVLVATFTQLKDKRQCLLIVMTMYSGFEQGFLAGDYTKAYVTCTIGIQYVGYVMICFGASNSIFSAIFGRISRFTGRIGLFAFATITNLASIIALFLWHPQLEQMAVFFVFPCLWGMADAVWQTQTNGMLTVVSDNIFIVNFAFPFYYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK86</accession>
    <name>A0A401NK86_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0012889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006374">
        <property type="protein sequence ID" value="GCB61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK86"/>
    <dbReference type="STRING" id="75743.A0A401NK86"/>
    <dbReference type="OMA" id="NAVRNKD"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39736" checksum="A5CC6FB99EF2D4B6" modified="2019-05-08" version="1">MGFQHFHTRKTFTPNIISRKVKEEPKEDDASQRKEKKDRERDRQREARGRGRGRPETIQSHSIFEQGPAEMMKKRAGWDSSVDMKEFGTSPIINIKKEKRESEEETKQILRMLDRDDFIDDPGLKNDARNMPVQLPLAQSGWLFKEEVEDEEVKPALPAKEGKMEVDLSSVKVKDEPGDDGVAKEVQMAQKASAVKKIPTVAEEVSVSELLEELSVCKDDELLFLQLPDTLPGQAPTRDEKPLKAEVQTEDGQTVVLKQEKAQEVKQAENSCSLMDLTEGQIGKLLIRKSGRVQLVLGQVTLDVTMGTTCSFLQELVSIGIGENRTGEMTVLGHVKHKLVCSPDFETLLEQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKM9</accession>
    <name>A0A401NKM9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bcl-2 Bcl-2 homology region 1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0012909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006389">
        <property type="protein sequence ID" value="GCB61399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKM9"/>
    <dbReference type="STRING" id="75743.A0A401NKM9"/>
    <dbReference type="OMA" id="PRFSYAK"/>
    <dbReference type="OrthoDB" id="8856583at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF56">
        <property type="entry name" value="BCL-2 BCL-2 HOMOLOGY REGION 1-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01258">
        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="4">
        <location>
            <begin position="40"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB61399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="190" mass="21302" checksum="034EB611A0069A6D" modified="2019-05-08" version="1">MGQEDSHSKRFVYVLIRDYLTFALRESGSVPAANSVAETLRKACALVQGSRKQELQHCIEKLNVASVEQARRALPVLIGEVYSDGTDNWGRLVTVYAFCGVLARHLRSKDIAEEELVEGIAQCVAQHTWTHKAAWIKENGGWEKGFVEYFQPNSPGFVDYVQQESPRFSYAKIAAITGIVAAFSFVMYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKX5</accession>
    <name>A0A401NKX5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0009357</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01003797">
        <property type="protein sequence ID" value="GCB61526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKX5"/>
    <dbReference type="STRING" id="75743.A0A401NKX5"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050796">
        <property type="term" value="P:regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000020">
        <property type="entry name" value="Hexokinase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000095">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF3">
        <property type="entry name" value="HEXOKINASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="71"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="278"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB61526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="439" mass="49135" checksum="2894C788F4FE97D5" modified="2019-05-08" version="1" fragment="single">RESVRGNPLPHPQERLRGGREKKKNPGERIGLKVTRGREAGRKEEALCATLGAGEPEPSGRARTDHSRMQKVQQILSEFQLEKGELLEVMRRIQREMERGLRLETHKTASVKMLPSYVRSTPDGSEVGDFLALDLGGTNFRVMLVKVGADEKRGWKIVTSNQRYSIPFAVMTGTAEMLFDYIALCISNFLDGYNMKDKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHSCEVGMIVGTGCNACYMEEMKNVELVEGEEGRMCVNTEWGGFGDTGELEEFRLEYDCLVDETSNNPGYQLYEKIIGGKYMGELTRLVLLKLVNQNLLFNGEASQLLKTQGSFETRFLTQIESFKHRFHTMVRELAPPCDITFLQSDEGSGRGAALISAVASKMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNG3</accession>
    <name>A0A401NNG3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urotensin-2 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Urotensin II receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0011460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005219">
        <property type="protein sequence ID" value="GCB62413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNG3"/>
    <dbReference type="STRING" id="75743.A0A401NNG3"/>
    <dbReference type="OMA" id="HRSFYRY"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001604">
        <property type="term" value="F:urotensin II receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14999">
        <property type="entry name" value="7tmA_UII-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000670">
        <property type="entry name" value="Urot_II_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF53">
        <property type="entry name" value="UROTENSIN-2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00647">
        <property type="entry name" value="UROTENSIN2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="49"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB62413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="366" mass="40952" checksum="2A8698DFB965CC0C" modified="2019-05-08" version="1">MHRNASDNLTAPGGEAAAAAPGPRATDEQLVTWAFGSVLSVMCVSGVAGNVYTLVVMCHSMRSAASMYVSIVNLALADLLYLSTIPFIVCTYFAKSWYFGDAGCRLLLSLDLLTMHASIFTLTIMCTERYLAVAKPLDTAKRSKGYRKATAGAVWLLSLLLTLPVMSMVQLQESRRENGSVSRLCAPTWSPEAYTVYLTVLFSTSIVAPGLIIGYLYTQLARTYLQSQRNTLANRGNRGSSKQRVVLMIFSIVVVFWACFVPFWVWQLIRLYCKSLNLTLRTITCINYFMTCLTYSNSCINPFLYTLLTKNYKEYLKNRHRHFQRSRSTSFKRNSNLRPSIKSISSCNQYSNSSETVAMAHLKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNN1</accession>
    <name>A0A401NNN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0007243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002582">
        <property type="protein sequence ID" value="GCB62495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNN1"/>
    <dbReference type="STRING" id="75743.A0A401NNN1"/>
    <dbReference type="OMA" id="CGEMGQL"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000091">
        <property type="entry name" value="Zinc finger CCHC-type-containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="113"/>
            <end position="140"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="31"/>
            <end position="56"/>
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    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="285" mass="33040" checksum="7DAF0B842655FFB9" modified="2019-05-08" version="1" fragment="single">EEQAAELRKNTMTRWARANNVHKRKLLEPTPWNQMKQNGNNGPNRTKLKNSQVKNQPTRYCKGPEIFKRKESEWYHKKEEYKSEDVNGFMDYLKETGQVLHKGTVVSVESQKIDEALALKKDQRREQRRLKRQIQKKNAMICFHCRKAGHRMEQCPEMDRDEEEMGSGICYRCGSTEHEIQKCRAKVDPALGEFPFAKCFICGETGHLSRSCPDNPKGLYADGRCCKLCGSVEHFQKDCPDHQNMRNCGLTVGRWTKGMSADYEEIPVTSNTHKAKQRVPKIVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNQ0</accession>
    <name>A0A401NNQ0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003910">
        <property type="protein sequence ID" value="GCB62511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNQ0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB62511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="78" mass="9347" checksum="84B617780E35ABF7" modified="2019-05-08" version="1">MRSRGLEMRGRGLVKMCWRLEMRSWKLGMRSWKLEMRSWRFGDEELEVGDEELGVGDEELQVGDEELQVGDEELEVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNS5</accession>
    <name>A0A401NNS5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005235">
        <property type="protein sequence ID" value="GCB62558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNS5"/>
    <dbReference type="STRING" id="75743.A0A401NNS5"/>
    <dbReference type="OMA" id="VAVWACQ"/>
    <dbReference type="OrthoDB" id="7852576at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="702" mass="79157" checksum="B1B7C179DAF507E7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNT3</accession>
    <name>A0A401NNT3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0011478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005230">
        <property type="protein sequence ID" value="GCB62516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNT3"/>
    <dbReference type="OMA" id="PLCACYD"/>
    <dbReference type="OrthoDB" id="9878438at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="265" mass="29816" checksum="3FCA24FA269541FC" modified="2019-05-08" version="1">MLTLPRSRSKFLNTLHRAIQVQQAVNRRSLWFEPTDIKIIDLQYFIFNQRGMVVLGFLQIACAAVCVVSGFMDTIFRKSSVLSRTRIPIWTGTAMAFPGVLALFSSQRKNPILVSSMIASAVFSWITTTILIIYAALTLNYGEDDDEVFQHKPSHTIHMEYILTKFVQGANMAILIASIIGMMMATIIAYLGCRSLPICACYDSTTGMQSLMSEDQQPQIIELVCTLHGGNNQRILNDPVEYNDWDIDTEEEEFASKPAPYIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP31</accession>
    <name>A0A401NP31_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0013089</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic cell membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic density membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006554">
        <property type="protein sequence ID" value="GCB62641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP31"/>
    <dbReference type="STRING" id="75743.A0A401NP31"/>
    <dbReference type="OMA" id="VHMLYPL"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017146">
        <property type="term" value="C:NMDA selective glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035235">
        <property type="term" value="P:ionotropic glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13719">
        <property type="entry name" value="PBP2_iGluR_NMDA_Nr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000010">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000012">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000025">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049872">
        <property type="entry name" value="NMDA1-like_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 22" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 22" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 22" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="24">
        <location>
            <begin position="202"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="25">
        <location>
            <begin position="209"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="23">
        <location>
            <begin position="242"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="20">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="20">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="471"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB62641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="612" mass="68390" checksum="74ABCF54E75EB631" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ40</accession>
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        </recommendedName>
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            <taxon>Carcharhiniformes</taxon>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <end position="38"/>
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        <location>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
    </feature>
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        <location>
            <position position="56"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
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        </ligand>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB63481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="486" mass="56538" checksum="41C2DD090EF8D00D" modified="2019-05-08" version="1">MAGVGSGGNDIQWCFSQVKGAIDDDVAEDFLYGKVVYQKITNMEVKILDFGSHGLLQGFKWISKLMYWMNKLWLLVPWKVPVLLVLLVKGEMIEKPNKQNKSQPHCRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPATVTTLKVPVFKPMDLMVEASPRRIFANAHTYHINSISVNSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNQCNTFVYSSSKGTIRLCDMRAAALCDKHAKLFEEPEDPSNRSFFSEIISSISDVKFNHSGRYMMTRDYLSVKIWDLNMESRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGCDSVVMTGSYNNFFRMFDRNTKRDITLEASRENSKPRAILKPRRVCSGGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSZ2</accession>
    <name>A0A401NSZ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0009748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004061">
        <property type="protein sequence ID" value="GCB63972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSZ2"/>
    <dbReference type="STRING" id="75743.A0A401NSZ2"/>
    <dbReference type="OMA" id="NIKXLSA"/>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21740">
        <property type="entry name" value="C2_II_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21750">
        <property type="entry name" value="ZnB-Zn_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057540">
        <property type="entry name" value="Znf_SUZ12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF0">
        <property type="entry name" value="POLYCOMB PROTEIN SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23320">
        <property type="entry name" value="Zn_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein SUZ12-like zinc finger" evidence="10">
        <location>
            <begin position="371"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="9">
        <location>
            <begin position="497"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB63972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="555" mass="63628" checksum="1C1B06599ED1BC58" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTR2</accession>
    <name>A0A401NTR2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0013312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006752">
        <property type="protein sequence ID" value="GCB64278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTR2"/>
    <dbReference type="STRING" id="75743.A0A401NTR2"/>
    <dbReference type="OMA" id="RPLGCKI"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000053">
        <property type="entry name" value="Aminotransferase, class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB64278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="308" mass="34707" checksum="6E3ACCBF4F57D5FA" modified="2019-05-08" version="1" fragment="single">SVPELISWMKDLQKRIHNPPTVDYSPEQGQMSLCVTNGSQDGLNKLFEMLVSSGDTVLLDTPTYPATLFTLRPLGCKIIGLSSDQHGLVPQSLSDILSKWEPEDAKNPLSDIPKVLYTIPNGANPTGASITAERKREVYQIARKYNLLIIEDDPYYFLQFEKPWAPSFLSLDVDGRVIRADSFSKILSSGLRMGFLTGPKPLLDRVVLHIQVSSIHVSTFTQLMVLQLLQQWGQDGFLKHIDSVVEFYAKQRDTMQLSAERWLKGLSKTGRTHQRGCVELERRRARSTSSQTKSKTIINNTLYLILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVF6</accession>
    <name>A0A401NVF6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0009881</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004145">
        <property type="protein sequence ID" value="GCB64855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVF6"/>
    <dbReference type="STRING" id="75743.A0A401NVF6"/>
    <dbReference type="OMA" id="WRNTIWN"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="166"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB64855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="260" mass="28870" checksum="471E5EB168769D8A" modified="2019-05-08" version="1" fragment="single">RFQIQRGKGDATSYKSLGHCFRTIFQQEGILGFYKGILPPILAETPKRAVKFLTFEQYKKILSYASLPSAVIFTVAGLGSGLTEAVVVNPFEVVKVSLQAQRNSFSEQPSTFAYARGIIRSQGFGLKGLNKGLTATLGRHGVFNMIYFGFYFNVKNIIPVNEDPTMEFLKKFGIGLLSGTIASCVNIPFDVAKSRIQGPQPKPGVIKYRTCFSTIKTIKREEGFFALYKGLVPKIMRLGPGGAVMLLVYEYAFAWLQENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWC5</accession>
    <name>A0A401NWC5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008142">
        <property type="protein sequence ID" value="GCB65183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWC5"/>
    <dbReference type="STRING" id="75743.A0A401NWC5"/>
    <dbReference type="OMA" id="FQVAVWG"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="108"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="258" mass="28707" checksum="FA538B376EAF9BAB" modified="2019-05-08" version="1">MSSRVAAAAAAGLGVALATGLGVVAGLWVAVGLGLAALGVGRLWGAYRQSHPELVRVGEISRLFIYPVKSCKGIPLTEVEVDELGMKKGPLKDRQWLIVDEKWRMITDPFETANVKSCEDVQTVYNDTSSCMMMSEATVEDFNTKLEIKVKMENFRPVVVVKDCKPYAEDTWKGLQIGTTKLYRRMACTRCIFTTVDPDTGIIDKKEPLETLKRYRQCDPAEKHIYKSVPVFGSHYGIEKPGVIRVGDPVYMIVEQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX93</accession>
    <name>A0A401NX93_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0009964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004205">
        <property type="protein sequence ID" value="GCB65486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX93"/>
    <dbReference type="STRING" id="75743.A0A401NX93"/>
    <dbReference type="OMA" id="LMHACTI"/>
    <dbReference type="OrthoDB" id="10070972at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040436">
        <property type="entry name" value="Disconnected-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021">
        <property type="entry name" value="DISCONNECTED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN BASONUCLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="719"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB65486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="810" mass="90981" checksum="8987971B1108CBBC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXC6</accession>
    <name>A0A401NXC6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008182">
        <property type="protein sequence ID" value="GCB65516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXC6"/>
    <dbReference type="STRING" id="75743.A0A401NXC6"/>
    <dbReference type="OMA" id="FRCPYEG"/>
    <dbReference type="OrthoDB" id="8902060at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035805">
        <property type="term" value="C:egg coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032190">
        <property type="term" value="F:acrosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035804">
        <property type="term" value="F:structural constituent of egg coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060468">
        <property type="term" value="P:prevention of polyspermy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051148">
        <property type="entry name" value="Zona_Pellucida_Domain_gp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23343">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23343:SF31">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="161" mass="18201" checksum="B1126F16BA47CF33" modified="2019-05-08" version="1" fragment="single">FDPQSSSPHPCFYNLRKSPVCTVDGQFLIVISRNLTRPALNLSSLYVKDGQEAECKPKLTTTQFVTFHFPITSCGSSKREEDGSMVYETDVLGKRMIQTGKLGSVTRDSTFRCPYEGDDYLTLLHPVGVFSGLEFPTHHKRFEVKTFVFLDGKLEQPLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXC9</accession>
    <name>A0A401NXC9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002857">
        <property type="protein sequence ID" value="GCB65538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXC9"/>
    <dbReference type="STRING" id="75743.A0A401NXC9"/>
    <dbReference type="OrthoDB" id="285802at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20528">
        <property type="entry name" value="CYCLIN_CCNJ-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB65538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="305" mass="34415" checksum="E39218806E315253" modified="2019-05-08" version="1">MELEEEWWKGQVVADIHQALRIKELRLPPYKSNSPQLNTRRYFADLLAIISNHFHLCPTARHLAVYLLDLFMDRYDISIQHLHLVALSCLLLATFQSKGTIPEVFWKVPAILGISVSSVSIFFPYTVCLFAAACIAASRAVLKLFPLWPVRLHRITAYAWDALLPCIERLLIAHDNDVKEANKQKGEQKGEPRNEQSIQQIGQTTFFTRPLACSKTRTEQQTSPCQYPMPSHLLQCSHLQCLHQQQSSQSGQATRYAIPACPSNLQINHATHGSIQANAMTLATTIEGKSCINIPYSRSYPVNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXS1</accession>
    <name>A0A401NXS1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001453">
        <property type="protein sequence ID" value="GCB65677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXS1"/>
    <dbReference type="STRING" id="75743.A0A401NXS1"/>
    <dbReference type="OMA" id="HAYLWEV"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="78693" checksum="A78564901FFD55A6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY43</accession>
    <name>A0A401NY43_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0013505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01006929">
        <property type="protein sequence ID" value="GCB65812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY43"/>
    <dbReference type="STRING" id="75743.A0A401NY43"/>
    <dbReference type="OMA" id="TAFMEKW"/>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000160">
        <property type="entry name" value="Serine/threonine-protein kinase 32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019131837" description="non-specific serine/threonine protein kinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB65812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="10181" checksum="E6C6365B3FADBEBF" modified="2019-05-08" version="1">MIVLNLFLLFFPLTVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQRLEHPFLVNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYI8</accession>
    <name>A0A401NYI8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004243">
        <property type="protein sequence ID" value="GCB65937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYI8"/>
    <dbReference type="STRING" id="75743.A0A401NYI8"/>
    <dbReference type="OMA" id="DFHHFAF"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="233"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="387" mass="44856" checksum="B6B74AA68478C61A" modified="2019-05-08" version="1">MIAGEDLHCQQASGREQYRVTHTHRTVTDSCCSLHSNRTGRFVRTKAAFYISTAKMRGYSEQPISVASQTQERHVWDSVKKAAFILGSGLFVFAAFRNTVTWYLQLFWGASGDFWQSQWVKAHGFFQGNEWVLFFLGTMVIPTLSFWIVNGLLLIVDATGKPQLITRYRIQRGRNDPVEPAKLQQAIRTVLFNQFFLSLPMVMVMYPIMKWRGNPCGTELPTFHWVLLELCFLGLLEEIFFYYSHRLFHHPVLYKYIHKKHHEWTAPIGVVSLYCHPVEHVMSNMLPPMVGPIFLRSHVATTMLWFSLALLLSTISHCGYHLPLLPSPEFHDFHHLKFNQCYGVLGVLDRLHQTDIIFRETKAYERHTLLLSLTPLSESIPDSLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ47</accession>
    <name>A0A401NZ47_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0010055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLITRK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004259">
        <property type="protein sequence ID" value="GCB66139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ47"/>
    <dbReference type="STRING" id="75743.A0A401NZ47"/>
    <dbReference type="OMA" id="CQERSIH"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000001">
        <property type="entry name" value="SLIT and NTRK-like family, member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF3">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019029567" description="LRRCT domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="528"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB66139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="830" mass="92507" checksum="34BC7C4699C14EC2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0V7</accession>
    <name>A0A401P0V7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004314">
        <property type="protein sequence ID" value="GCB66737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0V7"/>
    <dbReference type="STRING" id="75743.A0A401P0V7"/>
    <dbReference type="OMA" id="QWRICEE"/>
    <dbReference type="OrthoDB" id="5951542at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF14">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="270" mass="30736" checksum="DBACF65D586422B4" modified="2019-05-08" version="1">MATFQCRELEEKLSCAICLDIFTEPVTTLCGHNFCKSCLQGHLDSQGSAGLYDCPACRAVFQQRPGPLCKNLVLAEMVQFLKVRGSLPPHSEGELSGCLAHRKPLDLYCREEGLCICSVCATREHKGHDLVTVEDERLQREKELVAKHEEMERQVKKTEGLIDTLKMQRISVKDSASRAQTNYVNKFVMLKMELEEVQDKVSKYIENEEQVALEQADSALERLEEKCIELREVRLKLATILKSNDSVQILKVFFEVWLKGADLELQQCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1E5</accession>
    <name>A0A401P1E5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005718">
        <property type="protein sequence ID" value="GCB66927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1E5"/>
    <dbReference type="STRING" id="75743.A0A401P1E5"/>
    <dbReference type="OMA" id="PCLACER"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="280"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB66927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="83045" checksum="EA668F191048B4BD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1E9</accession>
    <name>A0A401P1E9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bardet-Biedl syndrome 10 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0012072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005718">
        <property type="protein sequence ID" value="GCB66923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1E9"/>
    <dbReference type="STRING" id="75743.A0A401P1E9"/>
    <dbReference type="OMA" id="PWELSEC"/>
    <dbReference type="OrthoDB" id="9393833at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042619">
        <property type="entry name" value="BBS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14667">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14667:SF2">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB66923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="74924" checksum="9F30206A7908D63E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1X5</accession>
    <name>A0A401P1X5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neuronal calcium sensor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0010205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004349">
        <property type="protein sequence ID" value="GCB67124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1X5"/>
    <dbReference type="STRING" id="75743.A0A401P1X5"/>
    <dbReference type="OMA" id="KEIREWY"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008048">
        <property type="term" value="F:calcium sensitive guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF198">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB67124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="166" mass="18881" checksum="0EB47E6DCF4A0240" modified="2019-05-08" version="1">MSKPARYKGFIKDCPSGQLDAAGFQKIYKQFFPCGDPTKFATFVFNVFDENKDGKIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2V7</accession>
    <name>A0A401P2V7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-13kD-A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase 13 kDa-A subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0008065</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS6 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003024">
        <property type="protein sequence ID" value="GCB67479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2V7"/>
    <dbReference type="STRING" id="75743.A0A401P2V7"/>
    <dbReference type="OMA" id="TACCDGG"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990204">
        <property type="term" value="C:oxidoreductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000002">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="14">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB67479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10471" checksum="CBA4D88C831C9FCC" modified="2019-05-08" version="1">MYSWIIRFIVNSVYEKDDYRKVRFVGRQKEVNESFAIDLVAEEPVTETSDRVVSCDGGGGALGHPKVYINLDKETKVGTCGYCGLRFKQIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4Q5</accession>
    <name>A0A401P4Q5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Protein-glutamine gamma-glutamyltransferase 2</fullName>
            <ecNumber evidence="25">2.3.2.13</ecNumber>
            <ecNumber evidence="28">3.5.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Isopeptidase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="34">Protein-glutamine deamidase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">Protein-glutamine dopaminyltransferase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="36">Protein-glutamine histaminyltransferase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="37">Protein-glutamine noradrenalinyltransferase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="35">Protein-glutamine serotonyltransferase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Tissue transglutaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Transglutaminase-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="ORF">scyTo_0013779</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="44 45" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>L-glutaminyl-[protein] + (R)-noradrenaline = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:66560"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:17054"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:72587"/>
            <dbReference type="ChEBI" id="CHEBI:167178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:66561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:16442"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:54817"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>L-glutaminyl-[protein] + dopamine = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:66556"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:17053"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:167175"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:66557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>L-glutaminyl-[protein] + histamine = 5-histaminyl-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:66564"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:17056"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:58432"/>
            <dbReference type="ChEBI" id="CHEBI:167179"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:66565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:66552"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:17052"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:167174"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:66553"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Secreted</location>
            <location evidence="6">Extracellular space</location>
            <location evidence="6">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="44">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="25"/>
    <dbReference type="EC" id="3.5.1.44" evidence="28"/>
    <dbReference type="EMBL" id="BFAA01007180">
        <property type="protein sequence ID" value="GCB68076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4Q5"/>
    <dbReference type="STRING" id="75743.A0A401P4Q5"/>
    <dbReference type="OMA" id="ISGGTYC"/>
    <dbReference type="OrthoDB" id="437511at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF6">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="24" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="19" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="21" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="45" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="43">
        <location>
            <begin position="276"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="42">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="42">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="42">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00039019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00040561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00041650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00041677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00042099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00042105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00042239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00042912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00043104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00043138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00047868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00047876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00048230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00048365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="EMBL" id="GCB68076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="693" mass="78107" checksum="96E7477493B27317" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4V7</accession>
    <name>A0A401P4V7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Synaptotagmin-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptotagmin XII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0000825</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Can also form heterodimers. Interacts with SYT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000171">
        <property type="protein sequence ID" value="GCB68126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4V7"/>
    <dbReference type="STRING" id="75743.A0A401P4V7"/>
    <dbReference type="OMA" id="LQPFGGW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08406">
        <property type="entry name" value="C2B_Synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000080">
        <property type="entry name" value="Putative synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000129">
        <property type="entry name" value="Synaptotagmin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030537">
        <property type="entry name" value="Syt12_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="167"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="298"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB68126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="436" mass="49287" checksum="9F7BDDCE38BCBC35" modified="2019-05-08" version="1">MGGPLKGKFQSQPSTMEENPAEYPTSVIKNPPGWEIGIYGSGVLIILMIVGVNLWKLWKSGNYPSPSPFPNYDYRYLEQKYGTSYSEVRQKRTMASTYKKHTEKSLLSRQSSLKIDETYETINELGTLELMTKDMELTSYRPMKKSISTDSLNSISSIGNNFGHDFTVGQIEMCLEYDMNSNTLHVTLVQGKDLLEKEDGNFESCFVRISLLPDEQIVGISRIQRNAFSVFFDERFSIPLDSSALEENSLRFSVFGIDEDDRNISTGLADLKLSDLDLSYRAFNAWLYLQDVNKATDTVGEILLSLSYLPTAERLTVVVVKAKNLVWNNGKTTSDPFVKVYLLQDTRKISKKKTAMKRDDPNPVFNEAMIFSVPAIVLQELSLRITVAECSEDGRTENIGHVIIGPESSGMGVTHWNQMLATLRKPVSMWHTLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P527</accession>
    <name>A0A401P527_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0013802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01007198">
        <property type="protein sequence ID" value="GCB68239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P527"/>
    <dbReference type="STRING" id="75743.A0A401P527"/>
    <dbReference type="OMA" id="CCGGCVI"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB68239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="188" mass="21616" checksum="A0A666B5F31B447F" modified="2019-05-08" version="1">MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNIKSFEDIHHYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLRKINTEEKTARCVPFKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P565</accession>
    <name>A0A401P565_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0005280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001627">
        <property type="protein sequence ID" value="GCB68284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P565"/>
    <dbReference type="STRING" id="75743.A0A401P565"/>
    <dbReference type="OMA" id="RVREYCF"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF13">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB68284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="226" mass="25320" checksum="0D1A5666196547F8" modified="2019-05-08" version="1">MEAKHPLKTQSLSLGGGLARAAGQGAAGSREPLWAAAAELRNPAAQHRDGEGESAHKIQRAVSFKAEGNQCYKEKKFREAIGKYHRALLQLKGIRSSEASGAEVNALSKTHIRLSEEQKRLIESTEIDCYDSLAACLLQSELVNYERVKEYCLKILGKHKDNFKAMYRAGIAFYHLGDCESALQYLKEAKDREPSDTNVFRYIQLTEIKMNRSNQREQEGSKEMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5Q8</accession>
    <name>A0A401P5Q8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CSL-type zinc finger-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0012282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase. Interacts with SERGEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005879">
        <property type="protein sequence ID" value="GCB68433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5Q8"/>
    <dbReference type="STRING" id="75743.A0A401P5Q8"/>
    <dbReference type="OMA" id="LFTYPCP"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB68433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="9595" checksum="BB35D799F9F94E16" modified="2019-05-08" version="1">MSVFHDEVEIEDFEYDEETESYYYPCPCGDKFIVSKEDLENGEEVATCPSCSLIVKVIYDKDQFMSGEVVEMVTTDKLEKLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P603</accession>
    <name>A0A401P603_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0005320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001642">
        <property type="protein sequence ID" value="GCB68547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P603"/>
    <dbReference type="STRING" id="75743.A0A401P603"/>
    <dbReference type="OMA" id="CYNISTQ"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF9">
        <property type="entry name" value="PROTEIN FURRY HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="329" mass="37791" checksum="33B4E8B9A9127CD8" modified="2019-05-08" version="1" fragment="single">MLSLQDSVFFEIGIKSLLKSWSSSSSAPVNTVTRRRISPGSNPSWEKKSVTMSNVTIDPDIKPGEYVIKSLFAEFTVQAEKKIEVVMAEPLEKPLSRSLQRGEDLQFDQVISSMSSVAEHCLPSLLRTLFDWYRRQNGTEDESYEYRPRSSTKSKGDEQHRDRDYLLERRDLAIDFIFCLVLIEVLKQIPLHPVPDALVHEVLNLAFKHFKHREGYSGPNTGNMHIIADLYAEVIGVLAQSKFQAVRKKFMTELKELRQKEQSPHVVQSIISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFHEVKDKDIKHALAGLFVEILIPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6L4</accession>
    <name>A0A401P6L4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007258">
        <property type="protein sequence ID" value="GCB68765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6L4"/>
    <dbReference type="STRING" id="75743.A0A401P6L4"/>
    <dbReference type="OMA" id="ERIWFSR"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19492">
        <property type="entry name" value="Rad51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="60"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="286" mass="31319" checksum="051488B19A281248" modified="2019-05-08" version="1">MVYTCIPLLHCLELGISKEEALEVLQIVRREASGEESQRSVGLPSVRKYTALELLEQEHAQGSIITFCSALDEILGGGVPIGKIVEICGAPGVGKTQLSIQLVVDTQIPECFGGLDGESVYIDTEGSFIVDRVMDVAHAAVQHCHLIAEAGQDEVQLEAAQAFSVSSILSRIYYFRCHDYVELLAQSHLLADFLAEHPKVRIVVIDSIAFPFRHNLEDLSLRTRLLNGLAQQLIGMANDHGVAVVLTNQMTTRFGPVQSTLVPALGESWGHAATIRLILRWEGKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P792</accession>
    <name>A0A401P792_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0013905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007288">
        <property type="protein sequence ID" value="GCB69011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P792"/>
    <dbReference type="STRING" id="75743.A0A401P792"/>
    <dbReference type="OMA" id="PTWQSTY"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB69011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="288" mass="33556" checksum="AD11DAF50B38AC53" modified="2019-05-08" version="1">MSLCYDPWPDPQVIGRFADSHELSELVYSASNLLVLVNDGILRKGIPQIPLVSVTQHRLLTWLTVLEHLEVFTEMSSAKLWGENCRWLVIIIIQLAKATLRILLLLWYKAGIQTSPPVTPLDRERHLQRSSIEAPSLPLRRWGIPQEEERQQRSQEESEQPATPLSHQETLAESLYITRPLLHLMALGIWGQKSWKPWLVSGILDIASLSLMRDPKQMRQAERAELRRRTFLLLYYLLRSPFYDRYSESKILFLLRVLADYVPGVGLVARPLMDYLPVWQKIYFYNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8Q1</accession>
    <name>A0A401P8Q1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 229A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0013977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM229 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007348">
        <property type="protein sequence ID" value="GCB69482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8Q1"/>
    <dbReference type="OMA" id="FHLVFYP"/>
    <dbReference type="OrthoDB" id="9925611at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31746">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31746:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 229A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB69482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40812" checksum="2700ABE1E42C7AB2" modified="2019-05-08" version="1">MNSKRRDAQRLLPAERPGQSSKRSRLPAACCPSRLKDLSGAESCGRSSPALPTWMRLYFYGMHGITLDVLLSSAQRFVQTSEPKMLGFSSPYRGVVHSLSHFALEKLYLHRRNLPGRPLVFHLLLYPSVYVSLHTLVGMVAPGWEPGSPLLALLLHYLLALYHSQLFLKRFLRLQCECSGRASLHPHRLCSPQQGLPDSLRFLFYGMHGFLDEIFFTSIFNLVEKWDRTLLGHTSLWSFLMYGSCSFVVEKLYFHLHYRWGWDTWRRLPVYILFIYTWELTWGLGLRHYGACSWDYSHYPLNFMGLVTLMYLPGWILLSYYQDVLSNVLLRVHYAKSKNSKTICTNGKNRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8Y5</accession>
    <name>A0A401P8Y5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Replication factor A protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0010573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004592">
        <property type="protein sequence ID" value="GCB69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8Y5"/>
    <dbReference type="STRING" id="75743.A0A401P8Y5"/>
    <dbReference type="OMA" id="TFHFIDC"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000149">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="12">
        <location>
            <begin position="172"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="277" mass="30089" checksum="32D0E5B600269F65" modified="2019-05-08" version="1">MWNNAGSFDGGYGGFGDTGAGGGGYLQSPGGFGSPAGGSQSDRKTRSRAQQIVPCTVSQLMSATQIEEVFRIGEVELSQVTVVGMIKDAEKAPTNILYKLDDMTAPPMDVRQWVDTDEVGSENIVVPPGSYVKVAGHLRSFQNKKSLVAFKIMALEDMNELTSHMLEVVQAHLLLNKPQPAPGGSLALHTPMRNENAMGMYAGGNDALMNGLTNQQSQVLNLIRNCREQEGMSIDYMKRTLKNMNIVAIKQAVEFLSNEGHIYSTVDEDHFRSTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9Q6</accession>
    <name>A0A401P9Q6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RWD domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0012494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006049">
        <property type="protein sequence ID" value="GCB69824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9Q6"/>
    <dbReference type="STRING" id="75743.A0A401P9Q6"/>
    <dbReference type="OMA" id="CKEKMCK"/>
    <dbReference type="OrthoDB" id="167315at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902073">
        <property type="term" value="P:positive regulation of hypoxia-inducible factor-1alpha signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033235">
        <property type="term" value="P:positive regulation of protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24164">
        <property type="entry name" value="RWDD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038840">
        <property type="entry name" value="RWDD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15628">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15628:SF1">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="246" mass="28005" checksum="A7DA7CC67A88B501" modified="2019-05-08" version="1" fragment="single">IHLRANHFSHTESEGITFQIHTTCEHHAKKIQLNIAFQLLPDYPTCLPDISIGSDQLTRKQCCDLKQSLLRYAETLVAQPMVYELMMWLQQNCEGAIEPFTGDKASGSDSLQQRCSTDDAAWMALVHLDHMRAKAKYIRSIEKWTSDLGLAGRLMFMGKLILILLQGQRKAIKDYLVLQKTSKVDVDSSGKRCKEKMISVLCEERLQAGQIRLTSFAVKEFTSGAEMHQEFEALGLSDLYDKFVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB70</accession>
    <name>A0A401PB70_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004702">
        <property type="protein sequence ID" value="GCB70361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB70"/>
    <dbReference type="OMA" id="FLMEMMM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="14633" checksum="04C29BF4D499EA9D" modified="2019-05-08" version="1">MLLVLMLLVSLMMLLLLLMMMLLMLMMLLVLLLVLMKLLVLMLLVLLMMLLMKLLVLILLVLLMMLLVLLMMLLMLLMMMMLLGLLMMLLVLLLMSSCLLMLLVLMMLSHLLMMLLVVLLLVVLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCK4</accession>
    <name>A0A401PCK4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Hyaluronan-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0001394</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000311">
        <property type="protein sequence ID" value="GCB70863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCK4"/>
    <dbReference type="STRING" id="75743.A0A401PCK4"/>
    <dbReference type="OMA" id="RHRDSAH"/>
    <dbReference type="OrthoDB" id="9937281at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.20.10:FF:000001">
        <property type="entry name" value="Urokinase-type plasminogen activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF40">
        <property type="entry name" value="HYALURONAN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0420">Kringle</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019237410" description="Hyaluronan-binding protein 2" evidence="16">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="18">
        <location>
            <begin position="183"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="19">
        <location>
            <begin position="302"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB70863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50050" checksum="70FD03F90C2872CC" modified="2019-05-08" version="1">MARVMALVYVCVILHAALPLTKSTDWYYGATDDEDDPDDPDFEDDENTMNSTDSRWLFEDSEEEDPCLVNPCENEGTCEAKGNDFICHCHPLYTGKTCQIVKNPCKKNTCKHGECVLNTVPPYHKCKCNYPFKPPNCRKPIRTCSINPCKNGGTCRTGRTRRSFTCICPKSFTGQYCETDANDCYEENGENYRGNVGTTEQGRICLHWSSHLLLRKNINIFGEQAEENGLGDHRFCRNPDDDNKPWCFFQEQNGKLKWDFCAISQCPRETTVAPETVTTTVLPTAFESCGEVSLRRTLSRIYALLKLRNVGGQCSKETKYVRTICLPDVALPLTSECYIAGWGTTETGNSSKYLLDASVKLISQRACNKEISYNGVIDETMTCAGNLEQGKVDSCQGDSGGPLSCVANGHYQVYGIVSWGDRCGVKNKPGVYARVVTFVNWIQEIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCK7</accession>
    <name>A0A401PCK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0008692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003379">
        <property type="protein sequence ID" value="GCB70856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="SQVCEMA"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF111">
        <property type="entry name" value="NEUROBEACHIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1675"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1788"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2197"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB70856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2405" mass="271629" checksum="3A9A93102DD4AF76" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCX5</accession>
    <name>A0A401PCX5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0001427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01000319">
        <property type="protein sequence ID" value="GCB70983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCX5"/>
    <dbReference type="STRING" id="75743.A0A401PCX5"/>
    <dbReference type="OMA" id="KGASWEW"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB70983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="384" mass="43675" checksum="61DA33E45414671E" modified="2019-05-08" version="1">MSSSPATASPDGNLQADIDDIITQYHSVFSRMGTLPYRYKILLKLNATPVIHAPRRVPAPLKDRLKKQLQDLQDQGIISKVTEPTDWVSSMVCVKKPSGICIDPKNLNRNITREHYSIPKREELTSEMAHAKFFTKLDASKGFWQIQLDVSSRMLCTFNPPFGRYCYNRMPFGIISASRVFHRIMEQMMECIEGVRVYVDNVIIWSTTPQEHTACLKQVFQRIHEHGLQLNRAKCSFGQLEIKFLGDHISQHGVRPDADKVSEINAIKTPEDKKAVLRLLGMVNFLRKFIPSMASHTMALCHLIKKSTEFQWLPTHEEEWRELKAKLTTAPVLAFFDPTKETNISTDASQDGIGAMHLQRDDSAFWAPVAYASRAVTPTEQCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEU2</accession>
    <name>A0A401PEU2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vang-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0001642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Vang family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000378">
        <property type="protein sequence ID" value="GCB71636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEU2"/>
    <dbReference type="STRING" id="75743.A0A401PEU2"/>
    <dbReference type="OMA" id="DKSVMIQ"/>
    <dbReference type="OrthoDB" id="8887313at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009539">
        <property type="entry name" value="VANGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20886">
        <property type="entry name" value="VANG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06638">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007991">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="589" mass="66933" checksum="9B53DEF59B938DB7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFP6</accession>
    <name>A0A401PFP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclosome subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0001752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the APC8/CDC23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000405">
        <property type="protein sequence ID" value="GCB71928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFP6"/>
    <dbReference type="STRING" id="75743.A0A401PFP6"/>
    <dbReference type="OMA" id="HWMKLFW"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000093">
        <property type="entry name" value="cell division cycle protein 23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="11">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB71928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="581" mass="67257" checksum="8F14AD2048F4F888" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH49</accession>
    <name>A0A401PH49_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0006294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002098">
        <property type="protein sequence ID" value="GCB72419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH49"/>
    <dbReference type="STRING" id="75743.A0A401PH49"/>
    <dbReference type="OMA" id="CESEMTM"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF20">
        <property type="entry name" value="ANOCTAMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="92"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="358"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB72419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="585" mass="67464" checksum="C3811FDB5E733FEB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI78</accession>
    <name>A0A401PI78_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 204</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Claudin-like protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0006490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002199">
        <property type="protein sequence ID" value="GCB72835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI78"/>
    <dbReference type="STRING" id="75743.A0A401PI78"/>
    <dbReference type="OMA" id="WKSCWLA"/>
    <dbReference type="OrthoDB" id="9928383at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000008">
        <property type="entry name" value="Transmembrane protein 204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038992">
        <property type="entry name" value="TMEM204"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14627">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14627:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019511821" description="Transmembrane protein 204" evidence="12">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB72835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="217" mass="24587" checksum="13ABCCFF2B2186E1" modified="2019-05-08" version="1">MAVQKLVATAVAVALLSLILNNAAAFTPNWVYQALEDGRKRSVGLWKMCYGIDKGKGSTRHEQTLHRDCENLNWGSEHSGFQESRNTVKLQFDMMRACNLIATVALTVGQLIFLLGLMELPLITQDSQWWEEAIAALFQLSSFVLVIGLVTFYRIGPYTHLSWSCYLDIGACLLSTLSAAMLIWNILHRREDCMTPRVIVIRRSRPRFENDYVESPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJU2</accession>
    <name>A0A401PJU2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peripherin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Retinal degeneration slow protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0006748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRPH2/ROM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002328">
        <property type="protein sequence ID" value="GCB73392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJU2"/>
    <dbReference type="STRING" id="75743.A0A401PJU2"/>
    <dbReference type="OMA" id="LCCFLMR"/>
    <dbReference type="OrthoDB" id="9836210at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03162">
        <property type="entry name" value="peripherin_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000002">
        <property type="entry name" value="Retinal outer segment membrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000830">
        <property type="entry name" value="Peripherin/rom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018498">
        <property type="entry name" value="Peripherin/rom-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042026">
        <property type="entry name" value="Peripherin_LEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF202">
        <property type="entry name" value="PERIPHERIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00218">
        <property type="entry name" value="PERIPHERNRDS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00930">
        <property type="entry name" value="RDS_ROM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB73392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="350" mass="40207" checksum="70E968E491D656F3" modified="2019-05-08" version="1">MAILKIKFNLQKRVKLAQGLWLLNWFCVLAGIVVFGMGVFLKVELRKRSEVMDNEESHLVPNSLILVGILACAINCFGGKFCYDSLDPAKYARWKSFLKFYLAACLFFTFLTFITVVFCFLMRIYLEDTLAKGLKNGMKYYRDTDTPGRCFMKKTIDHLQIEFRCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRVRSNVDGKYLTDGVPFSCCNPASPRPCIQQQIANNSAHYSYEFQTEELNLWTRGCKQALLNYYTNMMQSMGALVLFVWMLEVAVMVGIQYLHTSLDSIANPEDPECESEGWLMEKGLKETFKSLLESIKELGKFNQVATTEEGKKEEGTTVATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK56</accession>
    <name>A0A401PK56_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0002609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000667">
        <property type="protein sequence ID" value="GCB73529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK56"/>
    <dbReference type="STRING" id="75743.A0A401PK56"/>
    <dbReference type="OMA" id="AYICHSF"/>
    <dbReference type="OrthoDB" id="5572587at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04013">
        <property type="entry name" value="C2_SynGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000010">
        <property type="entry name" value="Ras GTPase-activating protein nGAP isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057606">
        <property type="entry name" value="SynGAP1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF52">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN NGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25321">
        <property type="entry name" value="PH_RASGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="239"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="458" mass="52539" checksum="56934CDEA741EE3F" modified="2019-05-08" version="1">MILGDVFRTEDVKGPPTHRLSCGQSPYTETAWDQKYCMLTDSQMILLNKEEEVNVDMLQDQQMESSKGRMLRRTVSVPSEGQFPDYQQDGSSKLEPPGERSPRRRSISGPGSSEKANGMEDSTSPFKGFFSKRLKGSIKRTKSQPKLDRNTSFRQILPSLRNSDNDRSRALPKLKESRSHESLLSPGSAVEALELSMEQDVFVKPLHSSILGQDFCFEVTYSGGSKCFSCSSVAERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKRYFCELCLDDTLYARTTSKMKADNLFWGEHFEFYTLPMVRNITVHIYKDMDKKKKKDKNNYVGLVNIPITSVIGRQFIEKWYPVSTPNPNKGKGGGPYIRIKCRYQTIAILPMEQYKEFAEFVTNNYTMLCSVLEPVISVKNKEEMACALVHILQSTGRAKCKDFTLELSYLKEIDDYLKSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMI9</accession>
    <name>A0A401PMI9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 39A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000938">
        <property type="protein sequence ID" value="GCB74364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMI9"/>
    <dbReference type="OMA" id="MENDEND"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF3">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59853" checksum="2821692DB4F80731" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNZ6</accession>
    <name>A0A401PNZ6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017401">
        <property type="protein sequence ID" value="GCB74835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNZ6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8158" checksum="90FC91C19E39ECD6" modified="2019-05-08" version="1">MQNRKRQLRTGGDNLEQEDMQECHISSDEEEVEEGGEGQPAGEEEEGPQAMARARLGRPVGMPKASRFVDEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQD3</accession>
    <name>A0A401PQD3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0018993</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013731">
        <property type="protein sequence ID" value="GCB75325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQD3"/>
    <dbReference type="STRING" id="75743.A0A401PQD3"/>
    <dbReference type="OMA" id="TITQCLY"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB75325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="169" mass="18033" checksum="F4DB2838D344BE35" modified="2019-05-08" version="1">MTSGGVTLPGESDMAAVVRLSLMCGRGFRPTFFSKSLAAGPLVASRKIQQPPVLLTSQIHTSPRYLAGSKAASLHWTSERILSVALLGLFPAAYIYPGGVMDYSLAAAVTLHGHWGLGEIVTDYVRGETKVKLAKMGLLILSAVTFAGLCYFNYHDVGICKAVAMVWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRI5</accession>
    <name>A0A401PRI5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Histone-lysine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.355</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">scyTo_0018252</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60276"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.355"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.355" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01012539">
        <property type="protein sequence ID" value="GCB75738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRI5"/>
    <dbReference type="STRING" id="75743.A0A401PRI5"/>
    <dbReference type="OMA" id="YESNEFT"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140949">
        <property type="term" value="F:histone H3K9 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18639">
        <property type="entry name" value="CD_SUV39H1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000008">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011381">
        <property type="entry name" value="H3-K9_MeTrfase_SUV39H1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009343">
        <property type="entry name" value="SUV39_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51579">
        <property type="entry name" value="SAM_MT43_SUVAR39_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="11 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 17 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 17 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Chromo" evidence="20">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="22">
        <location>
            <begin position="184"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="21">
        <location>
            <begin position="245"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="23">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="325"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR009343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR009343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR009343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GCB75738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="407" mass="46859" checksum="35EFA53AFCD33F10" modified="2019-05-08" version="1">MAEPRGRWCVPCLASLEILQELCREEKLTCAVLGIDKINLQEYEVEYLCGYKKEKGQEYYLVKWKGWPESTNTWEPRRNLRCIGLVKQFRDDHSKFLAKVKAAKRLKLNNCADYKSTVAEYIVMKSKQRLALKRWEEELNRKKNHQGKILVENEVDFEPPPMDFHYINQYKPSLGINLNSDALVGCECLNCLEGKCCPEEAGAQFAYNAQRQLRIAPGKPIFECNSCCSCGPQCPNRVVQKGTQYDLCIFRTSNGRGWGIKTLQKIKKNCFVMEYVGEVITSEEAERRGKFYDSKGITYLFDLDYVEDEYTVDAARFGNISHFVNHSCDPNLQVYNVFIDSLDTRFPRIALFSTRSIKPGEELTFDYQMKGSGDVSITETSEVNSSPKRQRRIECKCGSISCRGYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRT7</accession>
    <name>A0A401PRT7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0019810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015138">
        <property type="protein sequence ID" value="GCB75807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRT7"/>
    <dbReference type="STRING" id="75743.A0A401PRT7"/>
    <dbReference type="OMA" id="PARCDEW"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043184">
        <property type="term" value="F:vascular endothelial growth factor receptor 2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061041">
        <property type="term" value="P:regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000013">
        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF3">
        <property type="entry name" value="CELL ADHESION MOLECULE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019380722" description="Ig-like domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="43"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB75807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="143" mass="16521" checksum="AC4CFA4376A7FCA5" modified="2019-05-08" version="1" fragment="single">MFTALFTLKHNIFLPLFILRKLCLFAKCRDDCLKRLLLCFPLPVECQVVQAENVTVMEGDRAEIACKLHSYDGSIVVIQNPYRQTLFFNGTRALKDERFQLVSFTNKQLRIALSDIRVEDEGGYYCQLYSEDTHHQVAVVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS27</accession>
    <name>A0A401PS27_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0017401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011277">
        <property type="protein sequence ID" value="GCB75920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS27"/>
    <dbReference type="STRING" id="75743.A0A401PS27"/>
    <dbReference type="OMA" id="KAKRYHI"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040169">
        <property type="entry name" value="SUGP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340">
        <property type="entry name" value="ARGININE/SERINE RICH SPLICING FACTOR SF4/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340:SF0">
        <property type="entry name" value="SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="6">
        <location>
            <begin position="710"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="6">
        <location>
            <begin position="823"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="959"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB75920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115030" checksum="5C5D6B299DF5BC20" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSC4</accession>
    <name>A0A401PSC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide repeat protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0019833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell projection</location>
            <location evidence="1 8">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TTC30/dfy-1/fleer family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015181">
        <property type="protein sequence ID" value="GCB76012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSC4"/>
    <dbReference type="STRING" id="75743.A0A401PSC4"/>
    <dbReference type="OrthoDB" id="10249577at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039941">
        <property type="entry name" value="TT30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 8" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="184" mass="21112" checksum="E41FBDF5822917DF" modified="2019-05-08" version="1" fragment="single">SLVEQQPTDDPDTEINLGCLLYKEGHYEEACKKFTTAMQVVGYKPDLTYNIALCYYSMKQYAPALKYIAEIIEHEAAQEALTDMPPRSEEELDPVTLHNQALMNMDSKPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYENYYYKISTCTIGGSESILKYESELGSVVFICLIYLYFCPNLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU18</accession>
    <name>A0A401PU18_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012717">
        <property type="protein sequence ID" value="GCB76624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU18"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8024" checksum="509DFAF0F416EE57" modified="2019-05-08" version="1">MCNVANAAHVGHNQLADTQGAIHHFNKNPGESEANVILYTRVGRGGELPQLPRLFPFSDRLVSLRADDGLISIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUG1</accession>
    <name>A0A401PUG1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008869">
        <property type="protein sequence ID" value="GCB76779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUG1"/>
    <dbReference type="STRING" id="75743.A0A401PUG1"/>
    <dbReference type="OMA" id="VVYIMED"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23079" checksum="858C14811CF3F740" modified="2019-05-08" version="1">MLGEVRSADGSGGLQPSRFLIPETVSGSPFEMGSFNELYFNVDNGYLEGLVRGFKAGILSQGDYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDKLKEKMVVEFRHMRNHAYEPLGCFLDFITYSYMIDNVILLITGTLHQRSISELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLVVYIMEDWGLGYRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUN1</accession>
    <name>A0A401PUN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate kinase FGGY C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010145">
        <property type="protein sequence ID" value="GCB76815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUN1"/>
    <dbReference type="STRING" id="75743.A0A401PUN1"/>
    <dbReference type="OMA" id="LPCENKP"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="219" mass="23083" checksum="0C50F1A93E76F259" modified="2019-05-08" version="1">MPVSFRNDVLSPGSRVGKGLTTVAAQALGLPIGIAVAVSLIDAHAGGLGMIGMDVKGSNLPCENKPITSRFALICGTSSCHMGISKSPIFVPGVWGPYYSAMIPGFWLNEGGQSATGKLMDHVVQGHAAFAELESKAKASGKNVYMYLNSHLESIKKSYAVGMLTVDLHVWPDFHGNRSPLADPTLKGMVTGLTLSNNLDDLAKLYLATMQALAVSNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWN5</accession>
    <name>A0A401PWN5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010281">
        <property type="protein sequence ID" value="GCB77540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWN5"/>
    <dbReference type="STRING" id="75743.A0A401PWN5"/>
    <dbReference type="OMA" id="PIGRNHI"/>
    <dbReference type="OrthoDB" id="8915799at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="337" mass="37592" checksum="21AECC5F570DDD20" modified="2019-05-08" version="1">MSHSLSKLRFDPKERCLLPLKLALESKNVKLAQHALAGMQKLLVDERLMTAEKELEERQLLNQMLDSMKITPFLNEDLQVEVMKVLLCITYSSTFEINGSAVLKIAEVCIETYVASCHQRSINTAVRATLSQMLSDLAQQLRLKQESESEDGRPLQEDHHNKGPSISVESLCEDVVSVLAVLYEKLQRVVNNNQQLQLLYLECILSVLNSSSPIMHRHKGFTDLLWKQLCPALIVILGNPIHDKTISSGHVASMTESEAALSGVSDHGRGSGCSSTAPALIGPVARTIYYIAAELVRLVGCLESLRPVLQSLYHRLLLYPPPQHRVEAIKIVKEVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXT6</accession>
    <name>A0A401PXT6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exosome complex component CSL4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Exosome component 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0021141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC6. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with DDX60.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CSL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018215">
        <property type="protein sequence ID" value="GCB77853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXT6"/>
    <dbReference type="STRING" id="75743.A0A401PXT6"/>
    <dbReference type="OMA" id="PMVPVGW"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000024">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000135">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB77853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="21442" checksum="7E267AB979990F0F" modified="2019-05-08" version="1">MAPLKLCIPGERLCNIEDGTPGNGTYSRHGYIFASLAGYVVKENDNGMVPLVSVVRDTEPQLLPEVGVVVTCKVTSINPRFAKVHILYVRSTPLKGTFRGTLRREDIRATEKDKIEVYKCFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSEAGAQMVPISWCEMQCPKSHGKEFRKVARVQPEFLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXZ5</accession>
    <name>A0A401PXZ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014309">
        <property type="protein sequence ID" value="GCB77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXZ5"/>
    <dbReference type="STRING" id="75743.A0A401PXZ5"/>
    <dbReference type="OMA" id="IAIKWID"/>
    <dbReference type="OrthoDB" id="10396225at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19813" checksum="D2D4AF1EEAACB22F" modified="2019-05-08" version="1">MSLSKEEHEHSFWEKLSKPNDKANLSKFAKYKGSTDDGELMKPIEGEEVTKAIKGIDDKSVPGPDGMKLANVQNIHDKDETRLPRLFSLWLKSATIPDSIKKGRTFLIPKCEDQERLKDINNCRPINIGPMLLRLFTKIMVKHLSQAVCINPRQKVSWQQPLDAMKTLQSLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYC0</accession>
    <name>A0A401PYC0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009103">
        <property type="protein sequence ID" value="GCB78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYC0"/>
    <dbReference type="STRING" id="75743.A0A401PYC0"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="345" mass="39627" checksum="05DC9EDCE769654B" modified="2019-05-08" version="1">MVPLGSEIARVTAPDGGGAGIRYRSSPGVPQLFVVPRTGQILVVGSLLGVAALELSVYGQGRGRPGGLSQPLRLRLSVGDRGAGLSQGGRGARSAPEQLYYSVSVSENDKVGNAIYTIPDWKFQRRWFEVIAPLDAPVHIERDSGKVYLSKRIRAKSTIQITVKVNNQKELYIRMYVTELYIRMYVTELYIPMYVTELYIPMYTTEPYIPMYTTEPYIPMYTTEPYTPMYITEPYTPMYITEPYTPMYITELYIPMYTTELYIPMYVTELYIPMYVTELYIPMYVTELYIPMYVRELYIPMYITEPYIPMYITELCILMYVSELCIPMYIRELYIMAGTVVSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ37</accession>
    <name>A0A401PZ37_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010439">
        <property type="protein sequence ID" value="GCB78404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PZ37"/>
    <dbReference type="OMA" id="CLAEIWT"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919:SF2">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919">
        <property type="entry name" value="ZINC FINGER, C3HC4 TYPE (RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="2">
        <location>
            <begin position="4185"/>
            <end position="4304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="4316" mass="495686" checksum="EBE5DA1935F256B7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ74</accession>
    <name>A0A401PZ74_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Band 3 cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015746">
        <property type="protein sequence ID" value="GCB78418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ74"/>
    <dbReference type="STRING" id="75743.A0A401PZ74"/>
    <dbReference type="OrthoDB" id="9807011at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF10">
        <property type="entry name" value="ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="2">
        <location>
            <begin position="82"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="198" mass="22568" checksum="3572A606CC7B993A" modified="2019-05-08" version="1" fragment="single">HHTVYIGVHVPKSYRRRRRHRRRAGTKERSKERERTAEASDRSDTENNDDLVTGSLFKPLISPAAERIRFILGEDDESPAPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEEGGERWSKPHVATLSLHSLFELRTCIEKGLVLLDLEASTLPQITELIIDNQIANGLLKPELKEKGIALGYKLKTRKTPSSCGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q033</accession>
    <name>A0A401Q033_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017113">
        <property type="protein sequence ID" value="GCB78643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q033"/>
    <dbReference type="OrthoDB" id="9943553at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="281" mass="31245" checksum="E799791238E492D0" modified="2019-05-08" version="1">MMFGKNGIFGIGSSWKKVVRHESSKRKVVLTKVTLLQNDSQCEDILSDPVNSYNRLAKTGIPEDNPAQQTNNYMELAKSGFRSSFSEYAAVNEPPNCMLKLYKSESEDSGVELPSGANSPSTPSGSEQSFVVHRRESSCDSGMALSILSSFPAIQHCPFPADNRNSDKCSKIDGKAEGNQEAPVKVKKLHSASANWKKNSSSNRNFNQNPTIIDEEVTQPRRVSLVEIVIADTNSQLFESDTVEHGNETRLDQETLKRRPSSDSLNDYMEECCRLSQVRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0U3</accession>
    <name>A0A401Q0U3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0021247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01018487">
        <property type="protein sequence ID" value="GCB78913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0U3"/>
    <dbReference type="STRING" id="75743.A0A401Q0U3"/>
    <dbReference type="OMA" id="FERTEKC"/>
    <dbReference type="OrthoDB" id="9950135at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="306" mass="35129" checksum="B74C378AB6FEAE88" modified="2019-05-08" version="1">MSPYNTPILPVKKSDGTYRLVQDLRAINRIVQVRHPVVPNPYTILSKVPNEHKFFSVIDLKDAFWASPLAPNSRDLFTFEWEDQKTGRKQQYRWTVLPQGYTESPNLFGQALEKVLEQFRVTKGSSLLQYVDDLLVSGENQGEVERTTNKLLNFLGEQGLRVSKNKLRYVEKEVKYLGHLISAGKRRISPERIAGILAIKIPKTKRELRKFLGLIGYCRLWIDMYAQKTKGLYLKLLEEEPNILKWTDEEVKQVEDLKKALMTAPVLALPSLEKLFHLFATADKGTALGVLTQKLGDKRQPSCPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q331</accession>
    <name>A0A401Q331_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012096">
        <property type="protein sequence ID" value="GCB79829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q331"/>
    <dbReference type="STRING" id="75743.A0A401Q331"/>
    <dbReference type="OMA" id="MQIMVFA"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36963">
        <property type="entry name" value="HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36963:SF2">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="382" mass="36702" checksum="80583E0A971D2DA0" modified="2019-05-08" version="1">MGGTVMGSTVMGGTVMCGMVMGSTVMGGRVMGGTVMDSTVMGGTVMGSMVMGGTVMGGTVMGGTIMGGTIMGGTVMGSMVMDSMVMGGTIMGGTIMRGTVMGGTVMSSTPMGGTVMDSTVMGGMVMGSTVMGSTVMGSMVMDSTVMGGTIMGGTIMGGTVMGGTVMVGMVMGGTVMSSTVMRGTVMVGMVMGGTVMSSTVMGGTVMGSTVMDGTVMGGTVMDSTVMGGTVMDSTVMGGTVMGSTVMDSIIMGSTVMGGTIMGGTVTGSMVIGGTAMISTVMGSTVMDSMIMGSTVMGSMIMGSTVMGCTIMGGTVMGGMVMGRMAMVGTVMGSTVLGGTAMGGTVMGGTVMGSTAMGGVVMGGTVMSSMVMGSTVMGSTVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4B8</accession>
    <name>A0A401Q4B8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012213">
        <property type="protein sequence ID" value="GCB80211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4B8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13872" checksum="A612DA2E8FA845B8" modified="2019-05-08" version="1">MFKVKPAIGFKRKSGRGFNGKPAAAFKIKPEMPDSDFTGRALEVRQKCQSGKVKHKQDASEEDKRNFEKLPEKSDKPKGTYLEHTKRNNRGRILRSAFVNLEVNFLEVSYRLEVSPFQTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4J8</accession>
    <name>A0A401Q4J8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Clarin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0017138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010885">
        <property type="protein sequence ID" value="GCB80306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4J8"/>
    <dbReference type="STRING" id="75743.A0A401Q4J8"/>
    <dbReference type="OMA" id="ICCEYLA"/>
    <dbReference type="OrthoDB" id="10012538at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050957">
        <property type="term" value="P:equilibrioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF4">
        <property type="entry name" value="CLARIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25807">
        <property type="entry name" value="Clarin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB80306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20847" checksum="4004DFB8E137BDA8" modified="2019-05-08" version="1">MGVGQGMAVGWGMGVGRGNGSFEEESGLEVGRGVWEKESEFGVFPTLLDAIPASLHVSVILFSAAVIVFALVAAGFFMFNAFGRPYETLHGPNGLYLWNTIACSCGFMAMILFTSEVKIHHLSEKIANYKEANFVFKTHTEIFGYSFWLLFVCTMMHCINILLIRLAGIQFPFSKSKNTDSGDGGVDLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q593</accession>
    <name>A0A401Q593_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011003">
        <property type="protein sequence ID" value="GCB80544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q593"/>
    <dbReference type="STRING" id="75743.A0A401Q593"/>
    <dbReference type="OMA" id="AVWKGHC"/>
    <dbReference type="OrthoDB" id="252964at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000055">
        <property type="entry name" value="Putative microtubule-associated protein futsch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="822" mass="92346" checksum="123BEA93C9E0FDDB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5H4</accession>
    <name>A0A401Q5H4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011054">
        <property type="protein sequence ID" value="GCB80615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5H4"/>
    <dbReference type="STRING" id="75743.A0A401Q5H4"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB80615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8634" checksum="580D5C2F4EF31ECE" modified="2019-05-08" version="1">MNEGTIFPATDFNPGVDAEVLASALQGMECNKDDLIEILTQRSNAQRLIIAQIYNDSYGQVWNLAFCCYLSLYFAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7C5</accession>
    <name>A0A401Q7C5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0022141</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021379">
        <property type="protein sequence ID" value="GCB81237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7C5"/>
    <dbReference type="STRING" id="75743.A0A401Q7C5"/>
    <dbReference type="OMA" id="LRWKQDY"/>
    <dbReference type="OrthoDB" id="9166379at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000002">
        <property type="entry name" value="Interleukin 1 receptor accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF20">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB81237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="251" mass="28481" checksum="CA69E688B0507AD2" modified="2019-05-08" version="1" fragment="single">ALGVTLLILVTPIIVYHFWWMEIILLYRLYFGTDETVGDGKEFDVYMSYARNTEEEEFVLNTLRSVLENEYGYKVFIYERDSLPGGLITDETLACIGKSRRLVVVLSPNYLVSGTQALLELKAGTECMARTGQIRVILLEFIPVRKVSQVVELRKLKAVMATIKWEGERSRDLRSRFWKRLRVALPTKQTQASERKSERLMFKNAQDGDLLNPSVSEGSSPASNIHDERAIDAPPVSDNSTAQETKSPILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q870</accession>
    <name>A0A401Q870_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026812">
        <property type="protein sequence ID" value="GCB81579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q870"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="44" mass="5010" checksum="7BA00D6D1E92E63D" modified="2019-05-08" version="1" fragment="single">MLSVVSEMRMCSVCSAETGGRNLNCTTGEEQPNYRRDIRRSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8F9</accession>
    <name>A0A401Q8F9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022956">
        <property type="protein sequence ID" value="GCB81665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8F9"/>
    <dbReference type="STRING" id="75743.A0A401Q8F9"/>
    <dbReference type="OrthoDB" id="8947034at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024786">
        <property type="entry name" value="TORC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589:SF6">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="110" mass="12021" checksum="2AF90F9314FA628B" modified="2019-05-08" version="1" fragment="single">MGNAAPSPSPLSTSTLHSPLNSPLPPNSISTSPRRRVPLNPLILSAGESRRPHNKQFSPTMSPTLSSITQGIPLDTTNLAMDQRLPPYPFCQQQSQQQQAYPQSQQQGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q949</accession>
    <name>A0A401Q949_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027017">
        <property type="protein sequence ID" value="GCB81909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q949"/>
    <dbReference type="STRING" id="75743.A0A401Q949"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF4">
        <property type="entry name" value="CINGULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="25461" checksum="5CE65E158B3D844C" modified="2019-05-08" version="1" fragment="single">YAEFSPDLGTLPGQKSDLEKKIVELQYKLDEELADRQKDARSRVDLQMELEEAQEERTQLHTLYQKNRKELQNNMQELMEVKMEKETVEAEMRDLQDEMTAVQTELRRVRKSAGEDVDQEVLSELARTREELDMVSTAKQTVEDVLRQRERELTALKGVLKEEVSSHDKAMEDLTAQYQTDMEQLRRNFAEVSQVSAKRPLSSHLILLPITFNLGHPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9D3</accession>
    <name>A0A401Q9D3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0022854</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01024483">
        <property type="protein sequence ID" value="GCB81993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9D3"/>
    <dbReference type="STRING" id="75743.A0A401Q9D3"/>
    <dbReference type="OMA" id="YKSICEW"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008499">
        <property type="term" value="F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB81993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="341" mass="38906" checksum="97715E4DA9862512" modified="2019-05-08" version="1">MKLKRYLKVLVLGLLLASAYLMLHFRASWGLTRESGQSLRDLRTFLEQAKSKEEDENADGSSGIDFDALYSWQHASPPCEKGQALLILVTSANANIDHRNAIRNTWALGWQESPFPWQVVFLLGQVSDEGAADLVRLEQEQFQDLLVGSYLDTYRNLTLKVMHGLRWAVRTCQPAYILKTDDDCFVNTDRLPRFLVRDNPFRSRLYTGSLFAAGKREVIRNPWSKWYVSWQDYGKERYPPYMSGVGYVLSLDAATAILRVALSVRPIPVEDAYIGILAEVAGIPVLSSSRFSKHNVNWRVCNYRYLMVIHPLSAQQQQVAHQNMVQARTACSDNPDITRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAQ8</accession>
    <name>A0A401QAQ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Suv3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022136">
        <property type="protein sequence ID" value="GCB82450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAQ8"/>
    <dbReference type="STRING" id="75743.A0A401QAQ8"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041453">
        <property type="entry name" value="Suv3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18114">
        <property type="entry name" value="Suv3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suv3 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8553" checksum="C0A968F63EB45311" modified="2019-05-08" version="1" fragment="single">RLFHQAFISFRKYVMEVESLSVDLHIILNDICCGAGHVDDLFPYFLRHAKQVFPMLDCMEDLRKISDLRLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCL3</accession>
    <name>A0A401QCL3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01033034">
        <property type="protein sequence ID" value="GCB83138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCL3"/>
    <dbReference type="STRING" id="75743.A0A401QCL3"/>
    <dbReference type="OMA" id="ILCPGHS"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="608" mass="62896" checksum="F21BD5F3A7032448" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD45</accession>
    <name>A0A401QD45_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030778">
        <property type="protein sequence ID" value="GCB83309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD45"/>
    <dbReference type="STRING" id="75743.A0A401QD45"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="59" mass="6697" checksum="42F8B48AAD3FCA72" modified="2019-05-08" version="1" fragment="single">GIDQSVLKELPPDLLAEIESTMPLCERVKMNKRKRSTVKEKPNYAEISSDEGDNDSDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD47</accession>
    <name>A0A401QD47_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0023441</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029399">
        <property type="protein sequence ID" value="GCB83272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD47"/>
    <dbReference type="STRING" id="75743.A0A401QD47"/>
    <dbReference type="OMA" id="HCARIKR"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000678">
        <property type="entry name" value="Myoneurin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000816">
        <property type="entry name" value="myoneurin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000030">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB83272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="342" mass="38027" checksum="13731BAF44E50555" modified="2019-05-08" version="1" fragment="single">CNAAALEAAAGYLQMEDVVKICKAKTKSLEINLNNEPKALSDIQETKEPISCFTSPGTEKDIVQQGPGAGTCEETLFSNPGTNCDWKMDKLHLQPANMDRTSGSRGEEPKADQNFVLPVRGISSNKVRHCARIKRQSSCSVRKVVSRVCGESAAQLNMVSTDLQPNNIPHPELDNDYKNPVAANKIVQTTNGKPRRKCSRRRGTLSERCKSKRTAGGSRVRLAKPGSSDGEQLKLKPICNMCGKLFSEASSLRRHMRIHKGLKPYVCQLCAKAFTQCNQLKTHIRTHTGEKPYQCDICDKSFAQKCQLVFHNRMHHGEEKPYVCDVCNLQFATSSNLKIHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE23</accession>
    <name>A0A401QE23_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01039004">
        <property type="protein sequence ID" value="GCB83635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE23"/>
    <dbReference type="STRING" id="75743.A0A401QE23"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="16898" checksum="3A7020F60F965FFD" modified="2019-05-08" version="1" fragment="single">NEETEGSDAPADYLFCDGEGDEDDFFIIDHENVPGEDHEFILPQEGFPLRHEILDHPTTLDHFQDKTDSPHISSNEADSVSLTPTEGISLVSVSQPPFEHGFSTDYFNPIVRDMMCFYAEQGDVQMAISVLIVLGDRIKKEIDEQTQVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFA6</accession>
    <name>A0A401QFA6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0024729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="BFAA01054361">
        <property type="protein sequence ID" value="GCB84060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFA6"/>
    <dbReference type="STRING" id="75743.A0A401QFA6"/>
    <dbReference type="OMA" id="TEGRYCH"/>
    <dbReference type="OrthoDB" id="9985088at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF22">
        <property type="entry name" value="CHONDROITIN SULFATE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB84060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="13795" checksum="EE9751B46B31DA7F" modified="2019-05-08" version="1" fragment="single">MYQTVKYIFERYNGEYDWFYIIQDDSYTESDRIKGLVNHLSINTDLYMGRPEEFIGGETEGRYCHGGFGYLLSRSLLIKLQPHLENCRNDILSARPDEWLGRCIIDYVSVNCVSNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGJ1</accession>
    <name>A0A401QGJ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0025189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01075382">
        <property type="protein sequence ID" value="GCB84463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGJ1"/>
    <dbReference type="STRING" id="75743.A0A401QGJ1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB84463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="105" mass="11855" checksum="3D41C7004414A2E2" modified="2019-05-08" version="1" fragment="single">IYVRSTDIDRTLMSAQSDLAGLYPPHGRQIFNPDLKWQPIPVHTVPVKDEKFLKFPIPNCPRYEKLLEESMNSKTVQDKVKESQASVKNLSLLSVCAPACLCVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGQ0</accession>
    <name>A0A401QGQ0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01071919">
        <property type="protein sequence ID" value="GCB84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGQ0"/>
    <dbReference type="OrthoDB" id="10523582at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8504" checksum="A255F91A03547371" modified="2019-05-08" version="1">MLTSTILRPPQWDTGSLQSSDDQDSEKGSDSEFTNSQSWLESQRQNKQQSQRIQKNRLQKNQLRKRVKKQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH85</accession>
    <name>A0A401QH85_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01085871">
        <property type="protein sequence ID" value="GCB84677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH85"/>
    <dbReference type="STRING" id="75743.A0A401QH85"/>
    <dbReference type="OMA" id="ITWQEPC"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="202" mass="22692" checksum="BA785A29DA56A956" modified="2019-05-08" version="1" fragment="single">PASLTLNPKTANPWLILSSDLTSVKMGEQRQVLQDRPERFDRCACVLGAEGFKSGRHYWEVEVGDKTEWDLGVAKKSCDRKGRIKRMPDDGYWRLSLRGGGEYKAFTAPPTYLSLNVDPRKIGVYLDYEGGQVSFYNADDMSHLHTFTDAFVEKLYPYFCPCLNDGGKNAGLMKICWFNQDELQELSQAPSTTPSNLGTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHR8</accession>
    <name>A0A401QHR8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01101634">
        <property type="protein sequence ID" value="GCB84883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHR8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="159" mass="17840" checksum="C9F21A74C8F2815C" modified="2019-05-08" version="1" fragment="single">GSVNSNTARDQRLQRDREEGSESGNYPQERYSNGSEPGNYPKERYSNGSESGNYPQERYSNGSESGNNPQERYSNGSESVNYPQERYSNGSESVNYPQERYSNGSDSGNYPQERYSNGQEFIPGSCRDVSPVFTRQDPRRTVDNSSGVLSPPGCCRCPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI96</accession>
    <name>A0A401QI96_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01120956">
        <property type="protein sequence ID" value="GCB85121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI96"/>
    <dbReference type="STRING" id="75743.A0A401QI96"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="34" mass="4197" checksum="EDB72EB96BFB2CFA" modified="2019-05-08" version="1" fragment="single">EDLSRLRRKLEKQKKVEVFSDADEILMEEIKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJU1</accession>
    <name>A0A401QJU1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">I/LWEQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0026293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01179247">
        <property type="protein sequence ID" value="GCB85671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJU1"/>
    <dbReference type="STRING" id="75743.A0A401QJU1"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF34">
        <property type="entry name" value="TALIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB85671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="9654" checksum="2BB50AFC0FBB399C" modified="2019-05-08" version="1" fragment="single">QADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGAILANAVDDGQWSQGLISAVGVPPARFWVGGFKPFVLLRKDRFLTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKF1</accession>
    <name>A0A401QKF1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01216417">
        <property type="protein sequence ID" value="GCB85850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKF1"/>
    <dbReference type="STRING" id="75743.A0A401QKF1"/>
    <dbReference type="OMA" id="FALWNGF"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="179" mass="19813" checksum="9BEB16FC240B083D" modified="2019-05-08" version="1" fragment="single">PASLTLDPNTAHRSLVVSEDRTSVTHGDTELQIPDNPDRFDTCSCVLGSQGFTSGEHYWEVEVGDKINWDVGVARESANRKGGITLGLDHGYWAVLLRNGNEYTAIESPSVPLIPGANPRTIGVFLDYEGGQVSFYNADDMSVLHTFTDTFTEKLFPYFWIGFCADENAAPLKLRHFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKX7</accession>
    <name>A0A401QKX7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01228738">
        <property type="protein sequence ID" value="GCB86026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKX7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="15271" checksum="62C8CCAB7C663D18" modified="2019-05-08" version="1" fragment="single">RVSERAPERERERASAPERERERAREPERERERARQKEKESERAPERERERASERAPERERERASERQKEKESERASARKRKRASERARQKEEESERARAPERERERASERARKRKRGSERARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLZ1</accession>
    <name>A0A401QLZ1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01279081">
        <property type="protein sequence ID" value="GCB86404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLZ1"/>
    <dbReference type="OMA" id="RNVSSQF"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="9738" checksum="0E2AFF381796444C" modified="2019-05-08" version="1" fragment="single">RLRSMMPRDVDVKLQSVTKQFVALGKEIKEQLNQKHEEELQKQQSIQEQKRTESLQTVSDWERQTAGTERERETGIERERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QN60</accession>
    <name>A0A401QN60_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01340209">
        <property type="protein sequence ID" value="GCB86752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QN60"/>
    <dbReference type="STRING" id="75743.A0A401QN60"/>
    <dbReference type="OrthoDB" id="7457481at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="16970" checksum="A7DEAF48C16F683A" modified="2019-05-08" version="1" fragment="single">AQAVQSNLEPEAQAVPSNLEPETQAVQSNLEPEAQALLPKLEPKGKAVQSKLEPDAQAVQSNPEPEAQAVLSNLESKAQAVQSNLESKAQAVQSKLESKAQAVQSNPEPEEQAVLSNLESKAQAVQSNLESKAQAVQSNLESKAQAVQSKLEPEAQAVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNG8</accession>
    <name>A0A401QNG8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0027698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01385176">
        <property type="protein sequence ID" value="GCB86969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNG8"/>
    <dbReference type="STRING" id="75743.A0A401QNG8"/>
    <dbReference type="OMA" id="VKFSICI"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019442026" evidence="2">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB86969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="17387" checksum="D48006409332CEB7" modified="2019-05-08" version="1" fragment="single">MMQDLLVMLLMMQDLLVMPLMMQDLLVGAPDDAGSVGNGPDDSDPAGRAPDDAGSAGDVPDDAGSAGGAPDDAGSAGGAPDDAGSAGGAPDDARPAGGAPDDAGPAGGAPDDAGSAVGAPDGAGSAADDPDDAGSAGGAPDDAGSADGAPNDAGSAGGAPDDAGFAGGAPDCAGFVDGAPDGTGSADGTPNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNZ0</accession>
    <name>A0A401QNZ0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01400619">
        <property type="protein sequence ID" value="GCB87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNZ0"/>
    <dbReference type="STRING" id="75743.A0A401QNZ0"/>
    <dbReference type="OMA" id="TIHAKQR"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="200" mass="20662" checksum="3D1768D159763F72" modified="2019-05-08" version="1" fragment="single">DLGVAVVQRDLGVAAVLRDLSVAVVQRGLGVAVVQGDQGVAAVQKDLCVAVVQRDLGVAVVQRDLSVAVVQRDLSVAVVQRDLGVAAVLRDLGVAVVQRDLGVAAVQRDLDVAAVQRNLGISVVQGDLGVVVVQRDLGVTVVQMDLDVAAVQRDLGVAAVERDLGVAVVQRDLGVAVGQRDLGVAVVQRDLGAAVVRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGH4</accession>
    <name>A0A401NGH4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0012617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006148">
        <property type="protein sequence ID" value="GCB59864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGH4"/>
    <dbReference type="STRING" id="75743.A0A401NGH4"/>
    <dbReference type="OMA" id="AENAKPH"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000334">
        <property type="entry name" value="vesicle-associated membrane protein-associated protein A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF12">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="16">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB59864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="242" mass="27511" checksum="60916BD75CC8032D" modified="2019-05-08" version="1">MARPEQLLNLEPPNELKFKGPFTDVVTTNLKLSNPSDNNVCFKVKTTAPRRYCVRPNSGIIDAGTSINVSVMLQPFDYDPNEKSKHKFMVQSMFAPPDCQDMEAVWKEAKLDDLMDSKLRCVFELPSENEKTHELEMNKVTSTSLKTETSMMTKSTSSSLDDLDLRKVMDDCRILKSEVQRLREENKQLKEDDGVRMRRMPQSGNPMPSKNIMMKEEGPATRMIAVVVLFFILGTIVGKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGR8</accession>
    <name>A0A401NGR8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0012630</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01006160">
        <property type="protein sequence ID" value="GCB59911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGR8"/>
    <dbReference type="STRING" id="75743.A0A401NGR8"/>
    <dbReference type="OMA" id="MLVHHAL"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21782">
        <property type="entry name" value="MobB_NDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000057">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000118">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="132"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="426"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB59911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="526" mass="60582" checksum="CA6969DE34BB8A9C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGU1</accession>
    <name>A0A401NGU1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Negative elongation factor C/D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003639">
        <property type="protein sequence ID" value="GCB60143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGU1"/>
    <dbReference type="STRING" id="75743.A0A401NGU1"/>
    <dbReference type="OMA" id="ARINPDH"/>
    <dbReference type="OrthoDB" id="511287at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="69652" checksum="406361B605490B1E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH04</accession>
    <name>A0A401NH04_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal P4.1-associated protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere protein J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Centrosome assembly and centriole elongation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0012672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms homodimers. Associates with microtubules plus ends; binds to beta-tubulin subunits exposed on microtubule outer surface at its distal tip; also associates with microtubule lattice. Associated with the gamma-tubulin complex. Interacts with the head domain of EPB41. Interacts with LYST. Interacts with CEP152 (via C-terminus). Interacts with STIL. Forms a complex with STIL and SASS6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006188">
        <property type="protein sequence ID" value="GCB60064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH04"/>
    <dbReference type="STRING" id="75743.A0A401NH04"/>
    <dbReference type="OrthoDB" id="10252174at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902117">
        <property type="term" value="P:positive regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.450.20:FF:000001">
        <property type="entry name" value="Centromere protein J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009852">
        <property type="entry name" value="CENPJ_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026581">
        <property type="entry name" value="TCP10L/CENPJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058029">
        <property type="entry name" value="Tubulin-bd_CENPJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331">
        <property type="entry name" value="T COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331:SF25">
        <property type="entry name" value="T-COMPLEX PROTEIN 10A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07202">
        <property type="entry name" value="Tcp10_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25779">
        <property type="entry name" value="Tubulin-bind_CPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENPJ tubulin-binding region" evidence="14">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="13">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="13">
        <location>
            <begin position="918"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="13">
        <location>
            <begin position="954"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="444"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB60064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117802" checksum="8A2C51224724A356" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH55</accession>
    <name>A0A401NH55_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carboxypeptidase B</fullName>
            <ecNumber evidence="13">3.4.17.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0014128</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Preferential release of a C-terminal lysine or arginine amino acid.</text>
            <dbReference type="EC" id="3.4.17.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Zymogen granule lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.2" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01007467">
        <property type="protein sequence ID" value="GCB60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH55"/>
    <dbReference type="STRING" id="75743.A0A401NH55"/>
    <dbReference type="OMA" id="WEEPISM"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF20">
        <property type="entry name" value="CARBOXYPEPTIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019404844" description="Carboxypeptidase B" evidence="16">
        <location>
            <begin position="16"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="119"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="573" mass="65727" checksum="DC606E47A2DD9880" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH61</accession>
    <name>A0A401NH61_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0006841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002373">
        <property type="protein sequence ID" value="GCB60208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH61"/>
    <dbReference type="STRING" id="75743.A0A401NH61"/>
    <dbReference type="OMA" id="AIFHWIV"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000002">
        <property type="entry name" value="Solute carrier family 4 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000019">
        <property type="entry name" value="Solute carrier family 4 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="352"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="885" mass="99456" checksum="C5C9E45D675AE825" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NL17</accession>
    <name>A0A401NL17_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005109">
        <property type="protein sequence ID" value="GCB61565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NL17"/>
    <dbReference type="OrthoDB" id="9219488at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="10175" checksum="06F8F0401910F8C0" modified="2019-05-08" version="1">MTVANSGDSEKRSLADADMESDQEMFPDAADGHCSASNGEVQPETRMEAEPAAGEPGSSGQPQQMHLRSQLDDLPTSTIACNVDERVYVDALYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLG6</accession>
    <name>A0A401NLG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007687">
        <property type="protein sequence ID" value="GCB61690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLG6"/>
    <dbReference type="STRING" id="75743.A0A401NLG6"/>
    <dbReference type="OrthoDB" id="9986391at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="22356" checksum="B37A0CECAA7637FE" modified="2019-05-08" version="1">MYVCEQLCTVSNWKRISECEVPVTLDTETANPKLEVSKDLKNVRLTRTERRVDENDERFTVWESVLGSEGFTSGAHYWEVEVEGNRHWTLGVATESMERKTDTELIPGKGFWTIGRAKDKFQANSANKFDICVHEIPRKIGVYLSCDSGIVSFYSADTKSYVYTFTGCEFTEKLYPFFSTTHCDKWLRICPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLU4</accession>
    <name>A0A401NLU4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">ATP-sensitive inward rectifier potassium channel 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0007120</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002525">
        <property type="protein sequence ID" value="GCB61853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLU4"/>
    <dbReference type="STRING" id="75743.A0A401NLU4"/>
    <dbReference type="OMA" id="VITWFLF"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000036">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000002">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003268">
        <property type="entry name" value="K_chnl_inward-rec_Kir1.1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF20">
        <property type="entry name" value="ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01321">
        <property type="entry name" value="KIR11CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 15" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="17">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="18">
        <location>
            <begin position="188"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="14">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB61853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44876" checksum="FFF057644DA30DD2" modified="2019-05-08" version="1">MFTFLVPSYVAEKVTRYWPFKMENSEHISMISQVARRRVVSKDGHNNVKIDQVDGWAFLYLQDLWTTVIDMKWRYKLTLFTATFVITWFLFGILWYAIAFVHGDLELLHPPANHTPCVVNIETLTGAFLFSLESQTTIGYGFRCITEECPFAIILLIVQLVITTLAEIFVTGTFLAKIARPKKRSETIRFSYHAAIAIHNNKLCLMIRVANMRKSLLLQCQLSGKFLHNHITEEGETIKLRQANVNFRVDTGSESPFLTFPLTFHHIIDEKSPLNRYASATLRDKDFELVVILNATVESTGSACQIRTSYVPEEILWGYEFVPLMSLSPGGKYLVDFSFFDKLRKSSNPYFASEVLRYGDIDKLKLEEKYREDEQNKLFSRIQTVQSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMH2</accession>
    <name>A0A401NMH2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0007155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002543">
        <property type="protein sequence ID" value="GCB62060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMH2"/>
    <dbReference type="STRING" id="75743.A0A401NMH2"/>
    <dbReference type="OMA" id="HSCIECA"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF7">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="272" mass="30573" checksum="FE91F915012A8D76" modified="2019-05-08" version="1">MKQFDIPYPEAIFDIDYFIWNPKPFFSLAKTLYPGNYKPNDIHYFLGLLHDKGLLLRLYTQNIDGLERAAGIPSEKLVEAHGTFSTASCSLCNSSYPSEKAKAEILNDEIPRCKTCLGIVKPDVVFFGESLAKDFFSYRKDFKRSDLLIVMGTSLEIEPFASIVNSVQPHVPRLLLNWDPVGPFKQTPLKHTDVRKLGNLIDSVRVLVKLLGWATDLDELIKRETGASVQTRTDPGPMVPGNPELNKQAQTTGPSTYPHVASKFYKRPDIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMM1</accession>
    <name>A0A401NMM1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002545">
        <property type="protein sequence ID" value="GCB62087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMM1"/>
    <dbReference type="OrthoDB" id="10040649at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019413456" description="SEA domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="3">
        <location>
            <begin position="342"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="732" mass="80531" checksum="F6E46EE44A335BD5" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN26</accession>
    <name>A0A401NN26_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0011445</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005207">
        <property type="protein sequence ID" value="GCB62295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN26"/>
    <dbReference type="STRING" id="75743.A0A401NN26"/>
    <dbReference type="OMA" id="SNHIDEM"/>
    <dbReference type="OrthoDB" id="6272564at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140006">
        <property type="term" value="F:histone H3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20159">
        <property type="entry name" value="PWWP_BS69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000002">
        <property type="entry name" value="Protein kinase C-binding protein 1 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000011">
        <property type="entry name" value="Zinc finger MYND domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057053">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047268">
        <property type="entry name" value="PWWP_BS69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047269">
        <property type="entry name" value="ZMY11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057054">
        <property type="entry name" value="ZMYND11_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24324">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23461">
        <property type="entry name" value="ZMYND11_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="17">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="18">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="227"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB62295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="53834" checksum="85AF798328F83E14" modified="2019-05-08" version="1" fragment="single">SMKKKNTTKQAMGRYLGYIVSRMKERASELGKKGKESKHPMYRRLVHTPIDVASIQEKLNENKYKSFDEFKADAQLLLHNTILFYGADSDQAEVARALFKDTCHELAELQLCKNCFYLSNARPENWFCYPCVPNHELVWARMKGFGFWPAKVMQRQDNQVDVRFFGHHHQRAWIPSENIQDIGVNVHQLAVKRSLGWKKACDELELHQRFVREGRFWKSKAEDKMEEEAESSISSTSNEQQKSTQEPKSKKSRRNQHSDAKDEEPEPEIEAVSSSQEIPTVPPQTEKVSVATQTKKLSASSPRMLHRSTQTNNDIPCQNMCHEKYTKIFNDFKERMKAEHKRETERVVREALEKLRTEMEEEKRQAVNKAVVNMQAEMDRKCKQVKEKCKEEFMEEIKKLATQHKQFISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN68</accession>
    <name>A0A401NN68_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001240">
        <property type="protein sequence ID" value="GCB62331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN68"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8446" checksum="423F6F2A670AC1A0" modified="2019-05-08" version="1">MERFHQSTTSITAGDQENIYGNSWLLRLTFINLLFYLYTAKTFMSPLLKSSSELQFKTKGSGHRKFEKSMNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNZ0</accession>
    <name>A0A401NNZ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phospholysine phosphohistidine inorganic pyrophosphate phosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0004269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01001254">
        <property type="protein sequence ID" value="GCB62564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNZ0"/>
    <dbReference type="STRING" id="75743.A0A401NNZ0"/>
    <dbReference type="OMA" id="ATTWEDS"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07509">
        <property type="entry name" value="HAD_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000051">
        <property type="entry name" value="Phospholysine phosphohistidine inorganic pyrophosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF44">
        <property type="entry name" value="PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="270" mass="29500" checksum="2C6749E61EF12C10" modified="2019-05-08" version="1">MMAEWCKPVGRVKGVLLDISGVLYDSGEGGGVPIPGSTEAVKRIKEANLKVRFCTNETQATRETFVAKLQSLGFDIALGEVFAPAPAACQILKERGLRPHLLVHDGLLPEFNQVDQSNPNCVVLGDAAGNFSYKNLNEAFRVLIGLEKPVLLSLGRGRYYKETDGMKLDVGVYMKALEYACDIEAEVVGKPAKRFFLSALSDMDLEPDQVIMIGDDIVNDIGGAQQCGMKAVQVRTGKYRPCDEQHPTVKADGYVHNLAQAVKILLEHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNZ8</accession>
    <name>A0A401NNZ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000007">
        <property type="protein sequence ID" value="GCB62611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNZ8"/>
    <dbReference type="STRING" id="75743.A0A401NNZ8"/>
    <dbReference type="OMA" id="NSMEADR"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF25">
        <property type="entry name" value="RNA BINDING PROTEIN FOX-1 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB62611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="179" mass="19771" checksum="05CE33816EEC9634" modified="2019-05-08" version="1">MLPHTIPCTPAFLFLHEGNQEATAPPEAMAQPYPPAQYSAPQNGIPAEYAPAHPHATQDYAGQTTVPEHAMTIYTPTQTHSDQPCTDANTQSLTGTSTVPQTDEAAQTDSSQQLQSSETTEKQQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKVSETFQTCSLDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ36</accession>
    <name>A0A401NQ36_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0014570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007865">
        <property type="protein sequence ID" value="GCB63021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQ36"/>
    <dbReference type="STRING" id="75743.A0A401NQ36"/>
    <dbReference type="OMA" id="HGHVMCA"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15204">
        <property type="entry name" value="7tmA_prokineticin-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000069">
        <property type="entry name" value="Prokineticin receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF74">
        <property type="entry name" value="PROKINETICIN RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="68"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB63021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="375" mass="42986" checksum="FEFC49C9D05E354B" modified="2019-05-08" version="1">MVDHCANLSQYSDLSLSDVGSSPNHSCEYEQYMTSPDMRGQESDKTFYQARVVIGVALVCIMLVCGVGNFLFIVTLARYKNLRNITNLLIVNLAISDFIVAIVCCPFEMDYYVVRELSWSFGHVLCSSVNYLRTVSLYVSTNALLAIAVDRYLVIVHPLKPRMKFQTAYCVLTAVWLVSLIISIPSAYFTTETTFDAFPGSNGKIFCGQIWPADKELFYKSYFLFLFILEFVAPVTSMSLCYVQICRELWFKSMPGVQTNQIKKRLRARRKTVLVLMGILTAYILCWAPYYGYAIVRDFFPNVLLRERHSITVYYIVECIAVSNSMINTLFFITVKNNTFKYVRRILLQQWRATSMPDKSTIVQECRTSVLPVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQL5</accession>
    <name>A0A401NQL5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0007357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002645">
        <property type="protein sequence ID" value="GCB63193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQL5"/>
    <dbReference type="STRING" id="75743.A0A401NQL5"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="143" mass="15921" checksum="B9C17B73B79CD813" modified="2019-05-08" version="1">MGKCRGLRTARKLHNLRRDQKWHDKQYKKAHLRTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKSHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQM1</accession>
    <name>A0A401NQM1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0013162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006619">
        <property type="protein sequence ID" value="GCB63165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQM1"/>
    <dbReference type="STRING" id="75743.A0A401NQM1"/>
    <dbReference type="OMA" id="YESKWRS"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990226">
        <property type="term" value="F:histone methyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000501">
        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000526">
        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF20">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB63165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="127" mass="14201" checksum="95D0399F3D50FA3A" modified="2019-05-08" version="1" fragment="single">DLSTGDGCGGSSAGRMRCVICYRGFNSRSNLRSHMRIHTLDKPFICRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPPASLQPHSPPLVVSHSATLAHHIPTMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRS3</accession>
    <name>A0A401NRS3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007944">
        <property type="protein sequence ID" value="GCB63601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NRS3"/>
    <dbReference type="OMA" id="XEYLESE"/>
    <dbReference type="OrthoDB" id="21525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="556"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="636"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="730"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1679" mass="196392" checksum="962F721EF6FA9E53" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS28</accession>
    <name>A0A401NS28_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0011660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005378">
        <property type="protein sequence ID" value="GCB63723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS28"/>
    <dbReference type="STRING" id="75743.A0A401NS28"/>
    <dbReference type="OMA" id="MRVAMYY"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="4"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB63723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="343" mass="37141" checksum="83EBA0962056B4B8" modified="2019-05-08" version="1">MSQGVSRPTNVVTVEKRPIPEPGQNEVLLQMNAVGICGSDVHYWQHGKLGDFLMRKPMVLGHEGSGTVVKVGAGVQHLKAGDRVAIEPAYPLHNDDFCKSGRYNLSPRMFCCATPPYDGHLCRYYAHNANYCFKLPECVSSEEGAFIEPLSVAIHACRRGRVKLGSKVLICGAGPIGLLNLLVAKATGAAQVVICDLSSSRLEKAKEVGADFTILVTKETPQELAQEVEKVLGCMPDSTIECTGAEFCVHTGIYSTLSGGTVLLVGHGPALVSVPLLNAAIREVDIRGMFRYCNTYPMAIAMLASKKVDVKPLITHRFPLDQAVEAFETTKKRLGIKVMLKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSW3</accession>
    <name>A0A401NSW3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vigilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0014709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007996">
        <property type="protein sequence ID" value="GCB63993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSW3"/>
    <dbReference type="STRING" id="75743.A0A401NSW3"/>
    <dbReference type="OMA" id="HIPSEAH"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22405">
        <property type="entry name" value="KH-I_Vigilin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22413">
        <property type="entry name" value="KH-I_Vigilin_rpt10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22414">
        <property type="entry name" value="KH-I_Vigilin_rpt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22415">
        <property type="entry name" value="KH-I_Vigilin_rpt12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22416">
        <property type="entry name" value="KH-I_Vigilin_rpt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22417">
        <property type="entry name" value="KH-I_Vigilin_rpt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22418">
        <property type="entry name" value="KH-I_Vigilin_rpt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22406">
        <property type="entry name" value="KH-I_Vigilin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22409">
        <property type="entry name" value="KH-I_Vigilin_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22412">
        <property type="entry name" value="KH-I_Vigilin_rpt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000057">
        <property type="entry name" value="High density lipoprotein binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000061">
        <property type="entry name" value="High density lipoprotein binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000018">
        <property type="entry name" value="vigilin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000033">
        <property type="entry name" value="vigilin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000039">
        <property type="entry name" value="vigilin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000050">
        <property type="entry name" value="vigilin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF34">
        <property type="entry name" value="VIGILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="148"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="220"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="293"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="362"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="433"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="549"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="623"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="696"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="769"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="865"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="943"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1159" mass="130018" checksum="E2154BBC022A52A2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTV6</accession>
    <name>A0A401NTV6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0009793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01004092">
        <property type="protein sequence ID" value="GCB64321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTV6"/>
    <dbReference type="STRING" id="75743.A0A401NTV6"/>
    <dbReference type="OMA" id="PIYNGKG"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="74"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB64321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="319" mass="36825" checksum="E666ABDB6A087301" modified="2019-05-08" version="1" fragment="single">VIYLVVFHLSFVMFVWSYWKTIYTPPANPLKEFRLVKTDKEQYDREERPEAQQEILKRVAKDLPVYTRTANGAIRYCDRCQIIKPDRCHHCSACDMCVLKMDHHCPWVNNCVGFSNYKFFMLFLAYSLLYCLFIAATVLQYFIKFWTGDLPDTHAKFHVLFLFFVAAMFFISLLSLFSYHCWLVSKNRSTIEAFRAPMFRNGPDKNGYSLGFSKNLKQVYGDQGKYWLLPIFTSLGDGCSYPTRLVSQDPEQPNTSNHTEPAKNIADGQSLPPRPLSESQNRLLGGTDQHWLDEGSDEESSKDPNQNAAIDEESAKHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV27</accession>
    <name>A0A401NV27_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Peroxisomal coenzyme A diphosphatase NUDT7</fullName>
            <ecNumber evidence="13">3.6.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Nucleoside diphosphate-linked moiety X motif 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">scyTo_0000319</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="27">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:63001"/>
            <dbReference type="ChEBI" id="CHEBI:132021"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:50041"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="3.6.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64989"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67592"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="Rhea" id="RHEA-COMP:17276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
            <dbReference type="ChEBI" id="CHEBI:172371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:67593"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>acetyl-CoA + H2O = S-acetyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64992"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156266"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:64993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:49976"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132011"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:49977"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>choloyl-CoA + H2O = S-choloyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132020"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:50037"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:132014"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:50021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132015"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:50025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hexanoyl-CoA + H2O = hexanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:49980"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
            <dbReference type="ChEBI" id="CHEBI:132012"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:49981"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>malonyl-CoA + H2O = malonyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:172363"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:67469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132013"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67464"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:172362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:67465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>succinyl-CoA + H2O = succinyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67472"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:172364"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67473"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50028"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132017"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:50029"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nudix hydrolase family. PCD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.77" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01000060">
        <property type="protein sequence ID" value="GCB64725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NV27"/>
    <dbReference type="STRING" id="75743.A0A401NV27"/>
    <dbReference type="OMA" id="HFFTFKD"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000049">
        <property type="entry name" value="Peroxisomal coenzyme A diphosphatase NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000059">
        <property type="entry name" value="NUDIX_hydrolase_NudL_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01293">
        <property type="entry name" value="NUDIX_COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="30" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="30" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="31">
        <location>
            <begin position="41"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00050371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00051749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00059426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00072984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00079598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="GCB64725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="237" mass="26590" checksum="17E9A1688EBE84FF" modified="2019-05-08" version="1">MADAGRSLVSAQVNPRTSVKEKAKHVLKTYDVGNKYSDLTLPRASVLVPLLIKNEELQVLLTVRSMKMRSSRGEVCFPGGKQDTRDRTEIDTALREAQEEIGLPPDQVEVICKLVPIINKDDILVTPVVAFIADTFHPQPNADEVSDVFILPLYHFLKSEEHSSTLYDAGMLLHFFTFKDQQLNKSFTVWGLTAQICIIVAFIALGQSPLFKVDFDIDNPFASLEKYLMVKYATSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV53</accession>
    <name>A0A401NV53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000061">
        <property type="protein sequence ID" value="GCB64771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NV53"/>
    <dbReference type="STRING" id="75743.A0A401NV53"/>
    <dbReference type="OMA" id="SEDMMQW"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23806">
        <property type="entry name" value="UBCc_UBE2U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="333" mass="38275" checksum="B3026523CFDC36AC" modified="2019-05-08" version="1">MQSKAYLLLAREYAQLQEARLFGITVSPVRDDLLEWVATVQGLKDSLWEGASLQLSLKYTEDYDSTPPNVTFNTIPFHPNVDTVSAKPCIDFLENPRKWEEGFSLTTILLTIQVMLSNPVLENAVNVEAVEMLKENPSRYREMILECVRTSRKLKETGVKLAVKSFPVAHFQDQVSTPIYGKPLLIKRIAFADYHKAWSEIATSKATESCKDQMPVTYPNLQALYNGLGKEDLEKEIEAQNKEFNDVMYGVFGKKRKRQITLDQKLERIDRMKRSYIMDKPLEDSNSIILNLPTSITRKRPNTNTQEEEEWNKEVDSLIDWTTGLNIDDLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVR7</accession>
    <name>A0A401NVR7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome non-ATPase regulatory subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0009908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004156">
        <property type="protein sequence ID" value="GCB64978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVR7"/>
    <dbReference type="STRING" id="75743.A0A401NVR7"/>
    <dbReference type="OMA" id="HENENFK"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB64978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="747" mass="82435" checksum="5BE3C5B417053E67" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY93</accession>
    <name>A0A401NY93_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001467">
        <property type="protein sequence ID" value="GCB65862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY93"/>
    <dbReference type="STRING" id="75743.A0A401NY93"/>
    <dbReference type="OMA" id="KLRDMMM"/>
    <dbReference type="OrthoDB" id="112668at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19868">
        <property type="entry name" value="DSRM_DGCR8_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000021">
        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040375">
        <property type="entry name" value="DGCR8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="27026" checksum="7744C78DACF5E8C1" modified="2019-05-08" version="1" fragment="single">ENPSDPFGASVVIDGVTYGTGTASSKKLAKNKAARATLEILIPDFIKQTSDEKPKDSDELEYFNHISIEDSRVYELTNKAGLLSPYQILHECLKRNHGMGDTTIKFEVIPGKNQKSEYVMTCGKHTVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGRESNKMVKQEMSDKSVIELQQFAKKNKPNLHILNKLRDEMKKLARDREETRKKPKMTIMESAQPGSEPLCTVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P053</accession>
    <name>A0A401P053_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Polycystic kidney disease protein 1-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0012016</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005671">
        <property type="protein sequence ID" value="GCB66484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P053"/>
    <dbReference type="OMA" id="QWEATSD"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22831">
        <property type="entry name" value="Gal_Rha_Lectin_PKD1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF134">
        <property type="entry name" value="POLYCYSTIN-1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1323"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1450"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1490"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1728"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1764"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1854"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2063"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2099"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2139"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2188"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2228"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="18">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="16">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="19">
        <location>
            <begin position="523"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="17">
        <location>
            <begin position="1138"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1522"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1522"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1950"/>
            <end position="1963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB66484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2249" mass="252071" checksum="D584307F79F36F13" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P253</accession>
    <name>A0A401P253_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0010216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004358">
        <property type="protein sequence ID" value="GCB67215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31712" checksum="94215D072B7D8EE1" modified="2019-05-08" version="1">MLSYCGRALLIQLLPYWDWTLYSNSDCLIRNPYYFESGLESLQLADCISVCQRYPKVESLHRVDPKDVLQNYLRQNLPLIITDGAEEWVAQREFTVPFLTRLYSDHPALQNTKVCSYWDSHHSLENSPGAFLEEVHRQRLIQWAIQWKNCNKAAAKVIRAFYQRPYFLPPVVELAESNWLLMASGAEDGAMENTFVKVRDHDGDLLMWIAQLQGVFEIQLLPKGMCASRCTHYTLHLSPGETVAVPLQMWEVQYRPFSSIAIGLAATGNWLQDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3I9</accession>
    <name>A0A401P3I9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003044">
        <property type="protein sequence ID" value="GCB67692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3I9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="277" mass="31310" checksum="919DE49030CE16DB" modified="2019-05-08" version="1">MPGAQLESYTRLEQARERHKPGAQLEGYTRLEHSWRATHAWSTAREEHKPAAQLESYTCLEHSWRATHAWSTAGELHMPGAQLESNTSLEHIWRAPHVWSTSGELRMPGTQLESYTHLEHSWRATHAWSTAGELCTPGAQLESYTRLEHSWRATHAWSTAGELHTPGAQLESCSHLEYSWRPTHTWNTAVELHTPGAQLESYTCLEHSWGATHTWSTAGELHTPGAQLEGYTLLENSWRATHAWSTAGELHTTFPACVDTSKINVKNPPRHNSVSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P618</accession>
    <name>A0A401P618_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucose-fructose oxidoreductase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0015234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Promotes matrix assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008544">
        <property type="protein sequence ID" value="GCB68601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P618"/>
    <dbReference type="STRING" id="75743.A0A401P618"/>
    <dbReference type="OMA" id="HEERRWA"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000025">
        <property type="entry name" value="Glucose-fructose oxidoreductase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000233">
        <property type="entry name" value="Glucose-fructose oxidoreductase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF8">
        <property type="entry name" value="GLUCOSE-FRUCTOSE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="10">
        <location>
            <begin position="152"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB68601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="408" mass="45342" checksum="CC92C3810951256D" modified="2019-05-08" version="1" fragment="single">GYDRSDSPAAHACTELQPKQTEWKMLPGVGVFGTGTTARVLVPLLRAEGFTIEALWGRTEEEAKQLAEEMNISFYTSRTDDVLLHQDVDLICINIPPPLTCQIAAKALGIGKNVICEKAATSGDAFKMVKAARYYPKLMSIVDNVLRFLPAFVKMKQLIEEGYVGNVMICDVRVYWGSLLSSKYNWICDELMGGGGLHTMGTYIVDLLTHLTNKRAEKVHGLLKTFVKQNDNIHGIRHVTSDDFCFFQMLMNGGVCSTVTLNFNMPGPFIHEVMVVGSAGRLVARGTDLYGQKNSSFKEELLLADTMSINTPGLLEKAFSDIPLMYLKGIVYMVQALSKSFKDQEDRRTWAHKPVSMAASFEDGLYMQSVVDAIKRSSRSGEWEVIAVITEEPDSNLNLCDALQRNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P845</accession>
    <name>A0A401P845_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003182">
        <property type="protein sequence ID" value="GCB69282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P845"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB69282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="35" mass="4130" checksum="D8A5E4FAC207410E" modified="2019-05-08" version="1" fragment="single">MDDNAFRTDNSNGMLQFQGHLKCKSWLHFPLRIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8N6</accession>
    <name>A0A401P8N6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transmembrane protein 237</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0013981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transition zone in primary cilia. Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM237 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007353">
        <property type="protein sequence ID" value="GCB69527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8N6"/>
    <dbReference type="STRING" id="75743.A0A401P8N6"/>
    <dbReference type="OMA" id="CAVWNVV"/>
    <dbReference type="OrthoDB" id="550113at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029409">
        <property type="entry name" value="TMEM237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15383">
        <property type="entry name" value="TMEM237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB69527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44881" checksum="44F79DE98EAE3AA4" modified="2019-05-08" version="1" fragment="single">GLPRQRESRMASGEEARPPRTLPPVPSTTTKDVPINKPRKKKSRTSNGVETLVSSTGRRHSDSIEHLTPDLQDAAPQKKKKKKKLLAEAELETSFSQHNPSDVCNLYSGPDDEVSRKIKKKIKKTRLAGHSNELEVEEEDIIGDGQAPRPQGPIFSISAGTSQPVDKVFLERSRRFQATDRTQMQKLPEPVDVYMEVKSTITTRDVSLQAHRGFRIIGLFAQGFLAGYTVWNIIVVYVLSGNDFSMLPNLLKQYTMLVYPSQCLLYMLLTISTVSAFDRVNVADASMAMRRIVTLDPAALASLLYFTALLLSLSQQMPSDRLNRYRFKSSKGSNVTLWPSGSEFRILHPWIVVNLVVTILVGLAWIFLSYNPMLDYTEESEFGSHINDVVEPDEKIKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8Z0</accession>
    <name>A0A401P8Z0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0012444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006013">
        <property type="protein sequence ID" value="GCB69553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8Z0"/>
    <dbReference type="STRING" id="75743.A0A401P8Z0"/>
    <dbReference type="OMA" id="LLXSDLA"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB69553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="179" mass="19764" checksum="D448A9DF2D6102D1" modified="2019-05-08" version="1" fragment="single">SSSDMAFDSFGYGYILTNNVLTAANGAYVKQKLESKELGKYGLLYYNAFFMILPSMAIAYFTGDLQKAIEFEGWSNTVFVMEFLLSCVMGFILMYSTVLCTHYNSALTTTIVGCVKNILVTYIGMFFGGDYIFTWTNFIGLNISIAGSLVYSYITFTEEQSAKTSGNGNNVDIKGKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9Y6</accession>
    <name>A0A401P9Y6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rho guanine nucleotide exchange factor 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Guanine nucleotide exchange factor GEFT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rac/Cdc42/Rho exchange factor GEFT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">p63RhoGEF</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0001153</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000248">
        <property type="protein sequence ID" value="GCB69928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P9Y6"/>
    <dbReference type="OMA" id="ICHALML"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13241">
        <property type="entry name" value="PH2_Kalirin_Trio_p63RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11853">
        <property type="entry name" value="SH3_Kalirin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000152">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000038">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000368">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000184">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000008">
        <property type="entry name" value="rho guanine nucleotide exchange factor 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047053">
        <property type="entry name" value="Kalirin_TRIO_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF104">
        <property type="entry name" value="TRIPLE FUNCTIONAL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16609">
        <property type="entry name" value="SH3-RhoG_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23587">
        <property type="entry name" value="SH3_KALRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="23">
        <location>
            <begin position="274"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="22">
        <location>
            <begin position="462"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="836"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="970"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="1081"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="594"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1382" mass="153606" checksum="63240E6B17F5A995" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAH9</accession>
    <name>A0A401PAH9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003272">
        <property type="protein sequence ID" value="GCB70100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAH9"/>
    <dbReference type="STRING" id="75743.A0A401PAH9"/>
    <dbReference type="OMA" id="PLRCGKR"/>
    <dbReference type="OrthoDB" id="5104187at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053359">
        <property type="entry name" value="CRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577:SF2">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="352" mass="39287" checksum="A99432A49966C668" modified="2019-05-08" version="1">MEMLRCGKRLRYGKRLRCGKRLRCGNPLRCGNPLRCGNPLRCGNPLRCGNPLRCGNPLRCGNPLRCGNPLRCGNPLRCGKRLRCGKRLRCGNPLRCGNPLRCGNPLRCGNPLRCGNPLRCGKRLRCGNPLRCGKRLRCGKRLRCGNPLRCGNPLRCGKQLRCGKRLRCGKRLRCGKLLRCGKRLRCGNPLRCGKRLRCGNPLRCGNPLRCGNPLRCGKRLRCGKRLRCGKRLRCGNPLRCGKPLRCGKRLRCGKRLRWGKRLRCGNPLRCGNPLRCGNPLRCGNPLLCGKPLCCHFGTFALKHEWQDFPGGTVLQMQQGGMLVTLLCCVAALLESPTTGQIMMPPATSTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAL3</accession>
    <name>A0A401PAL3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ALK and LTK ligand 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0005615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ALKAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001773">
        <property type="protein sequence ID" value="GCB70150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAL3"/>
    <dbReference type="STRING" id="75743.A0A401PAL3"/>
    <dbReference type="OMA" id="SPMCMER"/>
    <dbReference type="OrthoDB" id="9807651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030298">
        <property type="term" value="F:receptor signaling protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070378">
        <property type="term" value="P:positive regulation of ERK5 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029364">
        <property type="entry name" value="ALKL1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28676:SF2">
        <property type="entry name" value="ALK AND LTK LIGAND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28676">
        <property type="entry name" value="ALK AND LTK LIGAND 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15129">
        <property type="entry name" value="ALKL1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB70150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25008" checksum="25861F5898F80A60" modified="2019-05-08" version="1">MMNFSNSVNTFPIKETPGFYLFRAVTATRREDASCQERQLALYCPVGKCYRVTAGGGFNLISTAMNGLRSLFFAGLVLLVITAGFCQERTDLTELGENKPLFNLILEIINQLQKQHGEQTNEVNYFPQGVDYTFDSQELPDNDVYHKEGRVEIVPRDLRKMKDKFLKHLTGPLYFSPKCNKHFNRLYHNTRDCTIPAYYKRCARLLTRLAISPMCVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB86</accession>
    <name>A0A401PB86_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="8">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0001265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01000276">
        <property type="protein sequence ID" value="GCB70383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB86"/>
    <dbReference type="STRING" id="75743.A0A401PB86"/>
    <dbReference type="OMA" id="RGHVAFH"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF9">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB70383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="262" mass="29101" checksum="3B43266B5D8222F4" modified="2019-05-08" version="1">MLGCGGREAECLPKAFLITMRLIILEDYDKASEWAAKYVANSIVQFKPGPNRYFTLGLPTALPRDHPESYHSYMWNSFFKHIDIDPNNAHVLNGNAPDLQAECDAFERKIAEAGGIKLFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAKETILANARFFNGDLSQVPTMALTVGVGTVMDAKEVMILITGSHKAFALYKAIEEGVNHMWTVSAFQQHPRTTFVCDDDATLELKVKTVKYFQGLMHVHNQLVEPLQSIKNYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBH9</accession>
    <name>A0A401PBH9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000282">
        <property type="protein sequence ID" value="GCB70474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBH9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10593" checksum="D667B4DA9F591AF6" modified="2019-05-08" version="1">MRIKVRREARIENFASRGGGHPVSNVRALVFGLYLSTRQLEMGDIPSEIEGIEDEEQLPAQEAECQALEGHIILSTGSMGRGKQICENQWQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD20</accession>
    <name>A0A401PD20_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L46, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003398">
        <property type="protein sequence ID" value="GCB71024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD20"/>
    <dbReference type="STRING" id="75743.A0A401PD20"/>
    <dbReference type="OMA" id="MLPRYCK"/>
    <dbReference type="OrthoDB" id="194611at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019053633" description="Large ribosomal subunit protein mL46" evidence="9">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="324" mass="36437" checksum="43B02A4F9726E207" modified="2019-05-08" version="1">MMMALRQVLIAAVPAPVPGFSLPAHLWWRFLVQDGGGGGDFAPPSRARRPGFGGWRPAGDGAARLGAPFRGGRPRPHPEAGGLATLRRGVPAACGHPVAGEEPDGKRVRAAAGTELEKSLYSDHELQVFEDEEKIRWRQAEDYDSEEEEDVGQDIVTAQDLEDMWEQKLRQFRAADREQEADKKDDRSTLNRRLDEKLTLLVKEKVGDEEIWLLPQSEWKPGETMRQTAERTLSALSGNELQAAFLGNAPAGFYKYKYPKAMRTSDTLGAKVFFFKALLVNGDLKARRKGDYVWVTKSELKDYLKPKYLRQVNRFIFDTAAMYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD70</accession>
    <name>A0A401PD70_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0001448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000325">
        <property type="protein sequence ID" value="GCB71058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD70"/>
    <dbReference type="STRING" id="75743.A0A401PD70"/>
    <dbReference type="OMA" id="HIERHEV"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF255">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB71058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="333" mass="39362" checksum="B8CD24546757266B" modified="2019-05-08" version="1">MASLNGSEELRKFSWSGIPRQVRPITWKLLSGYLPANAERRESTLQRKRAEYFAFIEQYYDSRNDEHHQDTYRQIAIDIPRMTPESLILQPKVREIHIDIPRTNPLIPLFQQASVQKIFERILFIWAIRHPASGYVQGINDLVTPFFVVFVFEYIEGVVENFDVSSLPDEVLQNIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALQELVSRIDEQVHKHLQQSEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVKWRKEILEEKDFQGLMILLQNLPTMHWGNEEISVLLAEAYRLKYAFADAPNHYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEP5</accession>
    <name>A0A401PEP5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0008879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003495">
        <property type="protein sequence ID" value="GCB71589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEP5"/>
    <dbReference type="STRING" id="75743.A0A401PEP5"/>
    <dbReference type="OMA" id="CYIKPGL"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB71589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="260" mass="29351" checksum="1AEEBA94A79AE943" modified="2019-05-08" version="1">MNRQEKNDAKANEPLVANPSGENQTPGENQNLEYNIEGMASFPEYFNQLDLLETHGHLIPMGTHSKWPRQSDEEDEVESDSDFKMKEMELENDPAGLLLWASEKNQISIVRRLLSENPDLVNVKDDDNYTPLHRAAYNDHIEVARELIAHGADVHARTVDGWTPLHSACKWNNAAIASFLLQHEADINAQTNGLLTALHLASGSKGTKETIELLLMNRYINSDLKNNVGETAYDVALRTNMYYYLFEITEKCTNSVPDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PET0</accession>
    <name>A0A401PET0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgin-45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000378">
        <property type="protein sequence ID" value="GCB71633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PET0"/>
    <dbReference type="STRING" id="75743.A0A401PET0"/>
    <dbReference type="OMA" id="IRTHMMQ"/>
    <dbReference type="OrthoDB" id="5959043at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45026" checksum="8DDB2B43BE03D19A" modified="2019-05-08" version="1">MRMANKVHIVQPIRGPGDGMETEEPAKPVENTTGLIKKCHHAPRTNVISNSSQIVTKPGVLQLGKVQPDQAIEVEAVKILVPKAAVIHEIPTKSTKLIDSAGSHKGELLSQLENTNELKRELTELKVSIEKYQSSERKLLQDKEGLSNQIRVQTEVNRELKKLLVASVGNDLQYHFERMAREKNQLILENETLTQNLAQLSEQLERMTIQCDVWRSKFLASRVMTEELTHARTSLQRHVRETQSAIQDLLSEREQFRQDMVDSHRFLEELLVSLQWGRQQTYYPSAQPHTTGELAAVNLKLAEAVNSRLLGKLNTSNAQKTNQVEFCNTPAEKMAEKVLKMLDPTLCSKGTADIPFCDTSPTSFLSNKKSIGRFHPYTRYENITFNCCNRCTGELTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF15</accession>
    <name>A0A401PF15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein DEK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in chromatin organization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003516">
        <property type="protein sequence ID" value="GCB71699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PF15"/>
    <dbReference type="STRING" id="75743.A0A401PF15"/>
    <dbReference type="OMA" id="MIKKAPT"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000779">
        <property type="term" value="P:regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000148">
        <property type="entry name" value="Dek, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044198">
        <property type="entry name" value="DEK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468">
        <property type="entry name" value="DEK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468:SF1">
        <property type="entry name" value="PROTEIN DEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="11">
        <location>
            <begin position="387"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB71699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="443" mass="49281" checksum="370355FCB9B87BAA" modified="2019-05-08" version="1">MYEEWIQESPDMGQWLPPAAWDLAACPTEGEGLSPGLKVSDILLSTEADSKMAALEKGDKAEGTKKRNKPDKSSTKEEEKDEQLESEEEEEEEERVGLLERSPIVEGKREKKKVERLTLQVTPSAKETFSIPEGRGTRLGEIERVQYFMGKTKAEDLRSLHKILYNRPGSIPTLKKNIRLFTGFSFESGSEQHKKKEEVLKKNPISVLKVICTVLDLERKGTKDEIVSKILNFLMKPKASGKSLPKPKKKRQKGGKKEHSSGSRKKSKAATVEEILTDESSSEDEKKAKGKSSDESDVEEEVEPPKKVSKKEKSTSKAVPKGKKTQITKATNVKKADSSTAKKTAAPAKKDLGSGAKKVTSIGRLAKKSESEDSSDDEPLIKKLKKPPTDDELKGTVMKLLVDANLEEVTMKQICKKVFASYPDYDLSDKKDFVKNTVKELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG49</accession>
    <name>A0A401PG49_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0001810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000422">
        <property type="protein sequence ID" value="GCB72064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG49"/>
    <dbReference type="STRING" id="75743.A0A401PG49"/>
    <dbReference type="OMA" id="THIITYM"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23803">
        <property type="entry name" value="UBCc_UBE2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000009">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="74"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB72064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="304" mass="34518" checksum="13A3EABDB74964B6" modified="2019-05-08" version="1" fragment="single">EESRTSLSSLPGVNRRLCFFFIILFPPSLLLYFIFLFLPSPPPPSSPHFLPFLVVSLSLSGSSPTTMAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKAHLKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKEYAEIIRKQVLSTKAEAEKDGVKVPTTLAEYCIKTKVPSSDNSSDLLYDDLYDDDIDEEEEEEEDADCYDDEDSGNEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHD9</accession>
    <name>A0A401PHD9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002121">
        <property type="protein sequence ID" value="GCB72509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHD9"/>
    <dbReference type="STRING" id="75743.A0A401PHD9"/>
    <dbReference type="OMA" id="DNANCSE"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002951">
        <property type="term" value="F:leukotriene-C(4) hydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901750">
        <property type="term" value="P:leukotriene D4 biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF19">
        <property type="entry name" value="GLUTATHIONE HYDROLASE 5 PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="223" mass="24258" checksum="BF2BEFFF11BAFB88" modified="2019-05-08" version="1" fragment="single">MKNRRSCCCLVVLLVVVLLAALTALLLLWKLHCSRGHNLYSKAAVAADSKECSEIGRDILVAGGSAVDGAIAALLCTSLINPQSMGIGGGSIFTIYDASKGPGTQWIAVPGELRGYKEAHRKFGKLPWKSLFEPSIKLAERGFPIPNYLKSLVTYPFFCEKILNSTLRSLFYHSNGSLLTHVKYPQLAKTLRAIADEGPDIFYSGRIGQDLIADIQKQTVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ35</accession>
    <name>A0A401PJ35_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Guanine nucleotide-binding protein subunit alpha-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0002370</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(12) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000595">
        <property type="protein sequence ID" value="GCB73140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJ35"/>
    <dbReference type="STRING" id="75743.A0A401PJ35"/>
    <dbReference type="OMA" id="TIANNRC"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031752">
        <property type="term" value="F:D5 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000004">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000754">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF85">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="201"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB73140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="44442" checksum="D37566807C690358" modified="2019-05-08" version="1">MLKMADFLPSRSLLAACFPSCVLTQREAEQLRKSKQIDELISRDKTYVRRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQKAKEEFRGTIYSNILKGIRVLVDAREKLRIPWGDPGNRQNGEVLMSFDTRALTGAAVGLMETRVFLQYLPAIRSLWADSGIQNAYDRRREFQLGESVKYFLDNLERLGDPDYIPTQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERRRWFECFDGVTSILFLVSSSEFDQVLMEDRQTNRLSESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVKTVSIKDYFSQYEGNPHELSDVQQFLVQCFRDKRREQQHKPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ73</accession>
    <name>A0A401PJ73_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0002368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000595">
        <property type="protein sequence ID" value="GCB73138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJ73"/>
    <dbReference type="STRING" id="75743.A0A401PJ73"/>
    <dbReference type="OMA" id="CATLKID"/>
    <dbReference type="OrthoDB" id="8795751at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050700">
        <property type="term" value="F:CARD domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06736">
        <property type="entry name" value="PDZ_CARD11_CARD14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000867">
        <property type="entry name" value="Caspase recruitment domain family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559:SF1">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="502"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="938" mass="107563" checksum="F40AB51E652B39EE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJC7</accession>
    <name>A0A401PJC7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phytanoyl-CoA dioxygenase</fullName>
            <ecNumber evidence="2">1.14.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Phytanic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phytanoyl-CoA alpha-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0006668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.18" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002291">
        <property type="protein sequence ID" value="GCB73201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJC7"/>
    <dbReference type="STRING" id="75743.A0A401PJC7"/>
    <dbReference type="OMA" id="RAHIMME"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB73201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="228" mass="26287" checksum="026DD4C56D974675" modified="2019-05-08" version="1">MAAVTRLKVVLQHLRPGITAFPTSGEVAAQASLRSLRYTLEGRLLTPEQRQFYEENGFLLIKKLVSDEDIQLFRDEFERICRREIEVPGITIMKDVAINKAEYVEGQHAVSKIQNFENNEILFKYCSLPEILKYVECFTGSDIMAMHTMLINKPPDTGKKTSRHPMHQDLHYFPFRPADQIVCAWTAMERVDRNNGCLVVLPGSHKGKMKPHDYPEWEAYMNTAMKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKD0</accession>
    <name>A0A401PKD0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glypican-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0002679</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000684">
        <property type="protein sequence ID" value="GCB73599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKD0"/>
    <dbReference type="STRING" id="75743.A0A401PKD0"/>
    <dbReference type="OMA" id="ILTHIWI"/>
    <dbReference type="OrthoDB" id="10010764at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019803">
        <property type="entry name" value="Glypican_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF31">
        <property type="entry name" value="GLYPICAN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01207">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 12" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB73599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24717" checksum="7FF9181CAB68C03A" modified="2019-05-08" version="1" fragment="single">MHPAVVASYSNIQNTISKPIQMGLHTDEFFRELLENSKKSLNGMFIRTYGQLYRQNSEVFRDLFTELKRYYTGGNVNLEETLNDFWARLLERIFQLINPQYHFTEDYLECISKYTDQLKPFGDVPRKVKVQVTRAFVAARAFVQGLTVGREVANRVSKVIPTVGCIRALMKMMYCPYCHGLPTVKPCNNYCLNVMKGCLANQADLDTEWNLFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLK2</accession>
    <name>A0A401PLK2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0003100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000822">
        <property type="protein sequence ID" value="GCB74016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLK2"/>
    <dbReference type="STRING" id="75743.A0A401PLK2"/>
    <dbReference type="OrthoDB" id="6491773at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000252">
        <property type="entry name" value="Cadherin related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019349755" description="Cadherin domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="921"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="121"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="234"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="365"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="457"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="575"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="696"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB74016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1087" mass="118918" checksum="E4E3CA8FB82E2AD9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLS1</accession>
    <name>A0A401PLS1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000833">
        <property type="protein sequence ID" value="GCB74048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLS1"/>
    <dbReference type="STRING" id="75743.A0A401PLS1"/>
    <dbReference type="OrthoDB" id="9906983at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="157" mass="17796" checksum="A1F164EF9CC6EC3B" modified="2019-05-08" version="1">MCIDRGIRLEHSTPLHPQSSGSVKRRNQDVKLCMTKLLMTRGRSWAKLVPEVQLAVNNLPLSHVGPDKHITPYFLMFKVQMNTAQQASGGVIPQYNPELAQEMIGLLSHMLPPKLPEPNEWSPQEGDWVQEKKNSNTLLRPKWKPPVCVNRSKVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMG7</accession>
    <name>A0A401PMG7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000910">
        <property type="protein sequence ID" value="GCB74295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMG7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="86" mass="10209" checksum="9411C656970DB198" modified="2019-05-08" version="1">MEGNPKIQQFNFLETSTRKAQRSARPPAKNERITETIESPASLRDPHRFYTEDTRRLPKERERCVVPAPHAMDIFFLGRKSRKHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNA3</accession>
    <name>A0A401PNA3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001026">
        <property type="protein sequence ID" value="GCB74585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNA3"/>
    <dbReference type="STRING" id="75743.A0A401PNA3"/>
    <dbReference type="OMA" id="QQQEWTY"/>
    <dbReference type="OrthoDB" id="9950422at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="277" mass="30465" checksum="11C84640244221B2" modified="2019-05-08" version="1">MVDNATIVAKATLHQGLGASNGLSLISPGSAHYQAPQGMKLEAVMENLQRQQQARLELEERQRKERERDVIRAGGDSQQQQQQQAMTAAVHQHLAAAQQAAALAAVRAAAMAGLGDAGLGSSGAHRPLIAAQRRRVPSALSDSEEEEEELQRDPEPGVDMGGELAEEGDEEEEEEEEEEEEEGMEDNQLHHPAGVPAPGHTLKGTPVQLSRFGQHHYHLPGESHSPAGVPQQAQSQQQEWTYEEQFKQANKEGRLRLLTIAIKKWFPAVWNYFPICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNH2</accession>
    <name>A0A401PNH2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001056">
        <property type="protein sequence ID" value="GCB74674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNH2"/>
    <dbReference type="STRING" id="75743.A0A401PNH2"/>
    <dbReference type="OMA" id="CRLAMEC"/>
    <dbReference type="OrthoDB" id="10004661at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF9">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH3 middle" evidence="1">
        <location>
            <begin position="220"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="2">
        <location>
            <begin position="316"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="50132" checksum="DDCD9CDC6E0F87C3" modified="2019-05-08" version="1" fragment="single">AFGVVFNSMLNVYPRTGNLQRTAKFYYLPNWSNSESGIPIGPNFPFPLTSKLNLNMYSTPGAGFEIATEPEAMYVHLLFALKDRHLGALEASFASTVYHSFAFLQNKWEQLIEDIWLGQINPKLKITDDVRMKLRVHLKPDPQRASELAAEFGSGFRGIARRVWPHLNLVVAVDSGSNELYGRHLKHFYCEGVPIYSPVYAATEGLIGVNLWPGKEERHYLLWPLSIFFEFIPVDLCSEGQPQTLFLDEVKENELYELIVTNTSGLYRYRMGDIVKVVGFHNQCPVVEFKCRRGQFLNVRGEKITEEAFYRTLLRAVSLWPGAMLLDYCCAQSGLLGPFCGSSDPHYEVFVEIKGVRNLSEDQRYKLDQCLQEDSEQYQSFRRKGSLGPVRVHIVAAGSFKALTDFIMANLGTSYSQFNMHRVLRNKDFLDFIQRKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNI9</accession>
    <name>A0A401PNI9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal transducer and activator of transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0003766</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the transcription factor STAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001056">
        <property type="protein sequence ID" value="GCB74675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNI9"/>
    <dbReference type="STRING" id="75743.A0A401PNI9"/>
    <dbReference type="OMA" id="WIEEKMW"/>
    <dbReference type="OrthoDB" id="19300at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16855">
        <property type="entry name" value="STAT5_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16849">
        <property type="entry name" value="STAT5_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.532.10:FF:000002">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.20:FF:000002">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.630:FF:000002">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000025">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000029">
        <property type="entry name" value="Signal transducer and transcription activator 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.532.10">
        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046994">
        <property type="entry name" value="STAT5_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035858">
        <property type="entry name" value="STAT5a/5b_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013799">
        <property type="entry name" value="STAT_TF_prot_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02865">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00964">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48092">
        <property type="entry name" value="Transcription factor STAT-4 N-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0010">Activator</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="697"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB74675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="895" mass="102800" checksum="E140F543F803E49D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPV3</accession>
    <name>A0A401PPV3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dephospho-CoA kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011119">
        <property type="protein sequence ID" value="GCB75081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPV3"/>
    <dbReference type="STRING" id="75743.A0A401PPV3"/>
    <dbReference type="OMA" id="DVDKEYH"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB75081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="231" mass="26076" checksum="4E587D4DD9471C0E" modified="2019-05-08" version="1" fragment="single">KKMFLVGLTGGIASGKSTVAAVFRELGCPVVDADQIARQIVEPDSPAYWAIVRSFGEEILLEDKKINREKLGNIIFTDGEKRQLLNSITHPEIHKAMLKQIFKYFIQGYRYVILDVPLLFETNKLAKFMKHTVVVYCDPQAQLTRLMKRNSLTQAEAERRIGAQMPLEQKRKLANHVIDNSGDSVSTYRQVCKLHSQLEDSLDFLAVRLLAVVTLTGIGGLLCILIKRCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRX3</accession>
    <name>A0A401PRX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012558">
        <property type="protein sequence ID" value="GCB75853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRX3"/>
    <dbReference type="STRING" id="75743.A0A401PRX3"/>
    <dbReference type="OMA" id="STATTWW"/>
    <dbReference type="OrthoDB" id="6243211at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037660">
        <property type="entry name" value="CCDC51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624:SF1">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46297" checksum="A435241E282E58BA" modified="2019-05-08" version="1">MMRQLVSVMCSCASCFPIATSTSLRVRLYCSKPMQKTITKSLSEANDAAQLKWVELSKDFSKRTVEHIRTTTNSLWEKYEEFVGLKEVQVAQLKVTEAEKAFMVARSVVRQSRETLESQQLKLKEVRDRLDRVSREDSHYLELATQEHKLLQEERRHRTTHENAEELERETFARFSAAVRESHEKERTRAERTKNWSVMGSVLGAMIGVFGSTYINRVRLQELKALLLEAQKGPINLQEALKEQASIHQIQNKELNKLVTNLKELVHEDAAVKQASKEAIVKPKKAESSFKLDPVLDALKEQASSSKQTSASLEGLQLKLTGLEQVLGKVASDMKTVKLITQVRPSQTVSSGLKQDWQALATENMIDGLAETEKRLESHIRASSVHNTVLTYAAFALTLPVLYMLFKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRZ9</accession>
    <name>A0A401PRZ9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016453">
        <property type="protein sequence ID" value="GCB75895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRZ9"/>
    <dbReference type="OMA" id="DFFFMEG"/>
    <dbReference type="OrthoDB" id="9972212at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020339">
        <property type="entry name" value="C20orf85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31909">
        <property type="entry name" value="CHROMOSOME 20 ORF85 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31909:SF2">
        <property type="entry name" value="RIKEN CDNA 2410004P03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14945">
        <property type="entry name" value="LLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="145" mass="16685" checksum="CD9CA7E20896337F" modified="2019-05-08" version="1">MGSKELLFSRTTSAGYRLAERPNADSLTGHSKPAADSQSQGKLTYLGTVQQDQVWRELIRAEWQGLKEWENNWSFLKDYDAKGRLKIQEPLPEYVSQFSDQVPNTTNQTFGSRIDSELGQALIRMDYRLQKENRKTKLDNDLIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS15</accession>
    <name>A0A401PS15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane channel-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009985">
        <property type="protein sequence ID" value="GCB75893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS15"/>
    <dbReference type="STRING" id="75743.A0A401PS15"/>
    <dbReference type="OMA" id="METIQYD"/>
    <dbReference type="OrthoDB" id="8938419at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050910">
        <property type="term" value="P:detection of mechanical stimulus involved in sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060005">
        <property type="term" value="P:vestibular reflex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF17">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB75893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21101" checksum="22E11EFAF023BB8B" modified="2019-05-08" version="1">MTFTPSFDCGPFSGKTKMFDVIMETIQYDFPAFIGKLFGYASNPGLILPGILLMVLAIYYLNATSKTYEAANLELKKKMQMLRDEQKNRRNNKNTVNPMLQDLEDLLPNNANVTKSELDKVVIEKQPAITNGVTKANGKYGKEMTLAPPPLKMVVTKPPNPRQASHLPGKQRSGTPGQGPRRPPPGQPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSS2</accession>
    <name>A0A401PSS2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0018305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012621">
        <property type="protein sequence ID" value="GCB76157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSS2"/>
    <dbReference type="STRING" id="75743.A0A401PSS2"/>
    <dbReference type="OMA" id="LETYLLF"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15619">
        <property type="entry name" value="PHD1_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15530">
        <property type="entry name" value="PHD2_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF14">
        <property type="entry name" value="ZINC FINGER PROTEIN NEURO-D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB76157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="152" mass="16989" checksum="6DA32D22AD7E594F" modified="2019-05-08" version="1" fragment="single">EEGEDELERHTLPFHRKNSHKPRKAPDGSIIPNTYCDFCLGGISGNKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECKSCSLCGTSENDDQLLFCDDCDRGYHMYCLNPPMSEPPEGSWSCHLCLQQLKEKASAYITLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU81</accession>
    <name>A0A401PU81_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0021022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017917">
        <property type="protein sequence ID" value="GCB76662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU81"/>
    <dbReference type="STRING" id="75743.A0A401PU81"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0401">Integrin</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB76662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10957" checksum="376E58BCCF98B443" modified="2019-05-08" version="1" fragment="single">TLLIIYPEKATVGYGGAPWLIILIAVLAGILVLALLVFLLWKCGFFKRSRYNDTVPQYHAVRIGKEERQLHMDEKKTQYQKEWMTHWIDSDGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUJ7</accession>
    <name>A0A401PUJ7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017956">
        <property type="protein sequence ID" value="GCB76816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUJ7"/>
    <dbReference type="OMA" id="EQDITEY"/>
    <dbReference type="OrthoDB" id="4779276at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052671">
        <property type="entry name" value="Acrosomal_SP-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571:SF34">
        <property type="entry name" value="ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571">
        <property type="entry name" value="URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="396" mass="42368" checksum="8E640AB2F811E98A" modified="2019-05-08" version="1">MSITGEQVTGEQVIAEQVIGEQVIGEEVIGEQVIGEQVIGEQVLGEQVFGEQIIDEQVIGEQVIGEQVIGEQVIGEKVIGEQVFGEQVTGEQVIGEQVTGEQVIGEQVIGEEIIGEQVIGEQVIGEHVISAQVIGEQVISEQVIGEQVISEQVIGELVIDEQVIGEQVVGEQVIGEQVIGEEVIGEQVIGEEVIGEQVIGEQVFGEQVIGEQVIDEQVIGEQVIGEQVIGEKVIGEQVIGEKVIGEQVFGEQVTGEKVIGEQVTGEQVIGEQVIDEEIIGEEIIGEQVIGEQVIGEHVISEQVIGEQVIGEEVIGEQVIGEQVIGEQVIGEQAIDEQVFGEQVIAEQVIDEQVIGEQVIGEKVIGEQVFGEQVTGEQVFGEQVTGEQVIVEQVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV13</accession>
    <name>A0A401PV13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MAP7 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0016631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010174">
        <property type="protein sequence ID" value="GCB76969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV13"/>
    <dbReference type="STRING" id="75743.A0A401PV13"/>
    <dbReference type="OMA" id="QIESSAC"/>
    <dbReference type="OrthoDB" id="9950647at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF5">
        <property type="entry name" value="MAP7 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB76969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="87854" checksum="EFED4F162B5315F5" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWH4</accession>
    <name>A0A401PWH4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0016691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010270">
        <property type="protein sequence ID" value="GCB77480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWH4"/>
    <dbReference type="STRING" id="75743.A0A401PWH4"/>
    <dbReference type="OMA" id="YINTAMY"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB77480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29663" checksum="5121674D23295E89" modified="2019-05-08" version="1" fragment="single">NFCAGFIPHMHYSDMADATRNGPQGGILQFMMSNKLEAAMWLSRLFTVYCSILFIFPFMGLYEAANFYQRALLANALTSALRLHQRLPHFQLSRAFLSQALLEDSCHYLLFSLIFVNSYPVTMSIFPVFLFSLLHATAYTKKIFDILGPASLAFLRSILDKISANQQNILKFVACNEIFLMPATVFMLLSGNGSLLQPFIYYRFLALRYSSHRNPYCRTLFSELKMLLHHLIMKPACPGFLRNMCLNCISFVSRLAPTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX14</accession>
    <name>A0A401PX14_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0016727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010304">
        <property type="protein sequence ID" value="GCB77675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX14"/>
    <dbReference type="STRING" id="75743.A0A401PX14"/>
    <dbReference type="OMA" id="WDAMDGS"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45048">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45048:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB77675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="396" mass="43545" checksum="D3674F8B70350950" modified="2019-05-08" version="1">METGPMETGTHKGVTMETGPGKRLHWRRTQIPFRVVTAHTDRASCCKFCFNDCRFLTCSFDGRVILWDLLTGTTVSEFGLQSTPLTECCISPDNQRLFTSSWDKSLKAWDVETGKVLWSVAHSRPLTCCDVSFDGKFVVTGTDIENGVYIRDSESGAPIANLQDQHRSTVTSCRFSPDGQRVASGSCDRTARIWDVSAHRTTMTLKKHTNVVSDCCFSQMGNVLCTASWDKTMMVWDLATGEFRSRGPKSLTHGHEGCISSCALSSDAALIVAGSYDQTISVWDTAGLYLKLVLKDSTVRLWDIENIDQVPAVKAEWKAHGEKVLQCAHCGKPFSCCHEDNSEFVTLCVFCRLSASPWTSHLTLTTLPSLSAPAPPRPAPPPPASHHGSRQGHTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXC6</accession>
    <name>A0A401PXC6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011646">
        <property type="protein sequence ID" value="GCB77789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXC6"/>
    <dbReference type="STRING" id="75743.A0A401PXC6"/>
    <dbReference type="OrthoDB" id="10013157at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042651">
        <property type="entry name" value="Rgs22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583:SF1">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10797" checksum="4074C7CEA3BD3C95" modified="2019-05-08" version="1" fragment="single">CLDREQGVAWVKNERLPAFLQSDCYFEYRLSKLLSQLECNTGPGTPEIDCTYHPWILESEEQPMPKVADKVEVAMKELYICLGEVIANLPGCQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYQ7</accession>
    <name>A0A401PYQ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">c-Myc-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0020649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016999">
        <property type="protein sequence ID" value="GCB78173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYQ7"/>
    <dbReference type="STRING" id="75743.A0A401PYQ7"/>
    <dbReference type="OMA" id="MMHYKEE"/>
    <dbReference type="OrthoDB" id="524165at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21937">
        <property type="entry name" value="ZIP_MycBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11270" checksum="646E9CDF5773A942" modified="2019-05-08" version="1" fragment="single">AGDSRREQFRRYLEKGGVLDMLTKVLVALYEEPEKPNNAMDFLKQHLGTAGPETADVETLRLEVIELRQKYELLLEENKDLKAKLAQFDPPKEEGQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZX0</accession>
    <name>A0A401PZX0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0018642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01013165">
        <property type="protein sequence ID" value="GCB78671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZX0"/>
    <dbReference type="STRING" id="75743.A0A401PZX0"/>
    <dbReference type="OMA" id="KTDDMAM"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF27">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="3">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="359" mass="40426" checksum="4A57DF9608EE3B35" modified="2019-05-08" version="1" fragment="single">KPGLSGHGVYELKPEYLKYFNLFFYHYYKSQQTKAEDDQKKRKKQANSNEALPPPLPPQFFSTFVKVTNILNCDILMLVLRTVLQRAVDSTGRLWSEAMVQKTLHLICMALQEEQRQLEGGVAEEDVTFDVYLKATRVGSSAVNAESILSLLEKLKHVHQLDAQKDMINWTLQMFDTVKKLREKSSPCSVTEAGSQKTNETIQDKDKAERKRKAEAAKLYRQKIMAQMSAMQRNFIESNKHLYEKATEAPRPGTIRTEEDSAPTTEDSGVALGPMQGATATEKIILTCILCQEEQEVKTDDMAMVLAACVQRSTALSKNRSRTVTNLGDNYDPIIMHSDLSCGTHVGSCGHVMHATCWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1M3</accession>
    <name>A0A401Q1M3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015962">
        <property type="protein sequence ID" value="GCB79256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1M3"/>
    <dbReference type="OMA" id="NECKIVG"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4370:FF:000003">
        <property type="entry name" value="General transcription factor 3C polypeptide, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="212" mass="23133" checksum="AAF76F0D300248D3" modified="2019-05-08" version="1" fragment="single">EQLVVVELSGIIDPDFLLKCRNECKIVGIDTEQPVMQVDKCVFAGEYEDVLGTCVIFEETCEPDPELEDKPLLKYKCHTAKKLLMKRTFLSEKKEGEESTGGVEYLKIKENNFTRRSGLICSFLPNRSSSKDDGGGVTSKEALDPLAVQDKDLSNASSGTEGEASDQESADLSRELENITDENPGADCGMKPDADNSVIELGEQGSKGEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1P5</accession>
    <name>A0A401Q1P5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011965">
        <property type="protein sequence ID" value="GCB79302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1P5"/>
    <dbReference type="OMA" id="HSEANDQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="11037" checksum="C5EEB235B6384FF1" modified="2019-05-08" version="1" fragment="single">IPVQEQGCVVNPSGTVGPNQDPMVRTQGSMDIFANCLRIALQVTNQQDKEVGVPNDRQAEFYMSVLIQSIRLVQLCRHTHQEGYRAHFVQLLQRTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q282</accession>
    <name>A0A401Q282_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010668">
        <property type="protein sequence ID" value="GCB79502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q282"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33632" checksum="120032E024F4DEB2" modified="2019-05-08" version="1" fragment="single">ASTLRKHQREHLGEKSFPCKVKLAHTAQELSLTGEQVPYIKELTEEEEFTRKLFGLSNPRITNGGSDMGMSDDTRVSMDTSDGDGEELAAASEIPERTDEEGTEVNTSQQCGMAAAVEEGEECLEGKMSDLEGSVDELKLNIVACVKEEACDALAAVVERECSEPSGSEEPAALGAESLQSPGAHGQHQAHAAGEENEDDLKPVESLHQEQVQRTESYLVTSNLLQRTLTEFKTDVSQNLQRNNEILEHHLQKNNEILQQHLQRNNEIHQQQNLVLCQLLQRTNETLNEMRLILSQIVVPAPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2X5</accession>
    <name>A0A401Q2X5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Laminin IV type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013424">
        <property type="protein sequence ID" value="GCB79716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2X5"/>
    <dbReference type="STRING" id="75743.A0A401Q2X5"/>
    <dbReference type="OrthoDB" id="5985440at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21199">
        <property type="entry name" value="LAMININ_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Laminin IV type B" evidence="6">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB79716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="169" mass="18153" checksum="AB6AECAC7DB094FD" modified="2019-05-08" version="1" fragment="single">GATVSHRERTGSHPVTWTGSGFARVPERGVLQFQINNIPYSMEYDLVIRYEPQFPEDWEKSANDVNIVLLERTASAEWAARPVTVSGRVRSSRSVTKSVDSVSAGRGHSAGSVASASQATGASQTASRVSAMGTQRSVTNRLELASSVEVTVWAKTVSDVPLVTMETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q351</accession>
    <name>A0A401Q351_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wnt inhibitory factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0016037</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009439">
        <property type="protein sequence ID" value="GCB79788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q351"/>
    <dbReference type="STRING" id="75743.A0A401Q351"/>
    <dbReference type="OMA" id="HICKCKV"/>
    <dbReference type="OrthoDB" id="10266706at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000276">
        <property type="entry name" value="Wnt inhibitory factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2170:FF:000001">
        <property type="entry name" value="WNT inhibitory factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013309">
        <property type="entry name" value="Wnt-inh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF32">
        <property type="entry name" value="WNT INHIBITORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01901">
        <property type="entry name" value="WIFPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019039500" description="Wnt inhibitory factor 1" evidence="14">
        <location>
            <begin position="32"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="WIF" evidence="16">
        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB79788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="376" mass="41449" checksum="6F4FEF8AA0790DAF" modified="2019-05-08" version="1">MGCSGTLLRSANLCLTLKLLVLLTEATRAEGSLNMWIDAHQARVLIGFEEDILIVSDGKMAPFTHDFRKAQQRMPAIPVNIQAINFTWQATEQALYFYEFQSLRSMDRDVMGDPTVNIPLRATISHKATVVQIGFPCLGNQDGVAAFEVTVVIMDVEGNVVLRTPHNAIFFKTCQRAKCPGGCRNGGYCTERQVCECPDGFYGPHCEKALCAPRCLNGGLCVSPGLCICPPGYFGINCDKANCTTTCYNGGTCFHPAKCICPPSYEGDQCEISKCRQPCRNGGKCTGRNKCKCVKGYQGDLCSKPVCEPDCGPHGSCIEPNKCECREGWHGRHCNKRYGTSLMNTLRSAGFKHRQHTPLPKEKVESHIPPESNYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4A1</accession>
    <name>A0A401Q4A1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="13">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0018036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012207">
        <property type="protein sequence ID" value="GCB80200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4A1"/>
    <dbReference type="STRING" id="75743.A0A401Q4A1"/>
    <dbReference type="OMA" id="HTITCET"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB80200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="13916" checksum="62CF0007E7C3926A" modified="2019-05-08" version="1">MSIGVPIKVLHEAEGHVVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGTGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q528</accession>
    <name>A0A401Q528_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010962">
        <property type="protein sequence ID" value="GCB80462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q528"/>
    <dbReference type="STRING" id="75743.A0A401Q528"/>
    <dbReference type="OMA" id="HCDADIA"/>
    <dbReference type="OrthoDB" id="10529273at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="197" mass="21542" checksum="597F583CDE9DE873" modified="2019-05-08" version="1">MRLRHCDADIATPALRLRHCDAGTATPALRRRHCDAGTATPALRRRHCDAGTATPALRRRHCDAGTATPTLRRRHCDAGTATPTLRLRCCDAGTATPTLRRRHCDADTATPALRRRHCDAGTATPTLRRRHCDAGTAMLALRRRHCDAGTVTPALRRRHSDAGTATPALRRRHCDGDTAMLALRCWHCDADTAMPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9B0</accession>
    <name>A0A401Q9B0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020505">
        <property type="protein sequence ID" value="GCB81968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9B0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="32" mass="3576" checksum="3AF874414CC12640" modified="2019-05-08" version="1" fragment="single">HCDTGANAQEDTRASNGLHTRKLDLQEKLTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9C2</accession>
    <name>A0A401Q9C2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0023194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027052">
        <property type="protein sequence ID" value="GCB81956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9C2"/>
    <dbReference type="STRING" id="75743.A0A401Q9C2"/>
    <dbReference type="OMA" id="YIMETHT"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF15">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="6">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="416" mass="45468" checksum="BB9F79571B1B1A42" modified="2019-05-08" version="1" fragment="single">FCHTTLPVDQFPPGYSFDTDDLNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAQRLNIPISQVNPRDAKACVIHGTDLKDMVQEQLDQILANHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIVANIPLALGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPKTDKLVNEKLISMAYGQIGERRNEVKGGNEGMGERVAGSAWHMDRSVRERERRNEGGRGREGRKRVGGSAWRRDRSVRERETREREGERERGRGNDGKGERWENQHGYGQIGERERDGEGVKGQHGAQTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9K5</accession>
    <name>A0A401Q9K5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025830">
        <property type="protein sequence ID" value="GCB82074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9K5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="66" mass="7074" checksum="9913D560B89474B5" modified="2019-05-08" version="1" fragment="single">VNGTACVSVCVCVCVIVRRWDISENELGNPSLCRYFFSDDYGIVGWSPRVTSASGQIKAVGGARGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAK5</accession>
    <name>A0A401QAK5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027355">
        <property type="protein sequence ID" value="GCB82413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAK5"/>
    <dbReference type="STRING" id="75743.A0A401QAK5"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF195">
        <property type="entry name" value="ENDOTHELIN-CONVERTING ENZYME-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="13053" checksum="473ADF5DD70AD344" modified="2019-05-08" version="1" fragment="single">FYGSISTIYFATIGLPLQVSGQLTLGENIADMGGLKLAYYAYQKWIRDHGPERPLPGLKYTHNQLLFIAFAQIRATNILLMIHSERLFSTFIGFSLVKLWDLVPGSFSSPEIRKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD14</accession>
    <name>A0A401QD14_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0023440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029396">
        <property type="protein sequence ID" value="GCB83270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD14"/>
    <dbReference type="STRING" id="75743.A0A401QD14"/>
    <dbReference type="OMA" id="FVHENIC"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB83270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12213" checksum="3979C79F268ADF0A" modified="2019-05-08" version="1" fragment="single">CAASNLKKVSLELGGKSPLIIFNDCDLDKAVRTGMGAVYFNKGENCIAAGRLFVEESVHDEFVQRVVKEIKKMKIGDPLNRSTDHGPQNHKAHLEKLLDYCEIGVKEGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDG1</accession>
    <name>A0A401QDG1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01033555">
        <property type="protein sequence ID" value="GCB83403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDG1"/>
    <dbReference type="STRING" id="75743.A0A401QDG1"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="2">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9612" checksum="1BE28EBF32EC86D4" modified="2019-05-08" version="1" fragment="single">PFVETRAAVHGLNMYQEIGFQKDSQDEFKASQSIHMDCYRWVKRDSYLPVGSQNLKAAAKAKLGYDPVELDPEDMCRMATEEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDL0</accession>
    <name>A0A401QDL0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0024211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01041172">
        <property type="protein sequence ID" value="GCB83479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDL0"/>
    <dbReference type="STRING" id="75743.A0A401QDL0"/>
    <dbReference type="OrthoDB" id="8955641at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="9713" checksum="B0340A74AE5C9360" modified="2019-05-08" version="1" fragment="single">MKRDWIDWDTNNDGVLDEQELEALFTKELEKVYDPKNEEDDMMEMEEERLRMREHVMSEVDTNKDRLVSLGEFLKSTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDQ2</accession>
    <name>A0A401QDQ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0024339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01043715">
        <property type="protein sequence ID" value="GCB83472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDQ2"/>
    <dbReference type="STRING" id="75743.A0A401QDQ2"/>
    <dbReference type="OMA" id="KMSPVDF"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB83472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="63" mass="7231" checksum="2BE1105E5C6CDC1B" modified="2019-05-08" version="1" fragment="single">MLFSIRSFVNKMSPVDFKDGFLSFQTSKYKLHYYETATGIKIVMNTDLGVANIRDVLSQIYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDQ3</accession>
    <name>A0A401QDQ3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0024389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01045152">
        <property type="protein sequence ID" value="GCB83510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDQ3"/>
    <dbReference type="STRING" id="75743.A0A401QDQ3"/>
    <dbReference type="OMA" id="CAWLQFS"/>
    <dbReference type="OrthoDB" id="5873721at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF17">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB83510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="158" mass="17005" checksum="5BA3D9311C16A678" modified="2019-05-08" version="1">MLAAQEVAQLYQTDFIRNARAVAALWAVCSLCFAVLEVVVLIEPSWVRTGAGPGPVGSFGLFEVCLETDWLPQCRGSLASLSPVPSFETAAVFVCMALVLVLASVCCCFSLYRCCSPATVYKVCAWLQFSAGTDRLPSPKPPKARPRLPIKGEPHAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDW3</accession>
    <name>A0A401QDW3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01042611">
        <property type="protein sequence ID" value="GCB83532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDW3"/>
    <dbReference type="STRING" id="75743.A0A401QDW3"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="60" mass="6755" checksum="B67BFBE604F26989" modified="2019-05-08" version="1" fragment="single">MQAPAERSLTFPGMHKAGGRRYKTFMIDDILAKDSRSHLELTLASRADFIIRPQALHSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDZ7</accession>
    <name>A0A401QDZ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0024438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01046674">
        <property type="protein sequence ID" value="GCB83591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDZ7"/>
    <dbReference type="STRING" id="75743.A0A401QDZ7"/>
    <dbReference type="OrthoDB" id="8922428at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF679">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB83591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="12282" checksum="40A1FF98E46DDE66" modified="2019-05-08" version="1" fragment="single">MTVCLVVRHKLADQKTRKTLAREEFRLLHYAGEVNYNVTGFLDKNNDLLFRNLKEAIFESGNGILNQCFERGELDDKKRPETAATQFKNSLVKLMEILMSKEPSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QES6</accession>
    <name>A0A401QES6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0024743</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01054888">
        <property type="protein sequence ID" value="GCB83880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QES6"/>
    <dbReference type="STRING" id="75743.A0A401QES6"/>
    <dbReference type="OMA" id="MNNDFTE"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18667">
        <property type="entry name" value="CD1_tandem_CHD3-4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15531">
        <property type="entry name" value="PHD1_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000001">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000017">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000011">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF28">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="177"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB83880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="32319" checksum="FACC06FBB5D5E087" modified="2019-05-08" version="1" fragment="single">GGDEEGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPEMEKAPEGKWSCPHCKEGVQWEAKDENSELEAEGDVELEECVLGEPEEEEDDHMEFCRVCKDGGELLCCDACPSSYHIHCLNPPLPEIPNGEWLCPRCLCPQMKGKVQRILHWKWGEPPPPTPVPRPPDADLDAPSPKPLEGRPERQFFAKWVGMSYWHCSWVSELQLELYCSVMFRNYQRKTDMDEPPTFDFGVEDDGKSSKRKNKDPQYAQLEEQFYRYGIKQEWMMIHRILNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF76</accession>
    <name>A0A401QF76_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0024577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01050370">
        <property type="protein sequence ID" value="GCB84026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF76"/>
    <dbReference type="STRING" id="75743.A0A401QF76"/>
    <dbReference type="OMA" id="DCDALYH"/>
    <dbReference type="OrthoDB" id="9978677at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990450">
        <property type="term" value="F:linear polyubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026254">
        <property type="entry name" value="RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004">
        <property type="entry name" value="RING FINGER PROTEIN 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB84026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="213" mass="22718" checksum="B06FB5841F82B35E" modified="2019-05-08" version="1" fragment="single">DCDALYHRHPSRGGHQRVTLPTGERRPTPSRGAVGHLPGMKALSAGCSWPGLPCTATPYPVEQEDTARMAARPGLGRRSLSADHPSGWQSMPRPDRRPSDLAAALGQPRSIWTCASCGLLNEARAVLCGACDRPRASPAPLPAAGETRLSGSLRECWSCQACTFRNDPSAVLCSACERPRLAGKPSFTPGTVTDSILEHTLPPMPKMSEQVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFD4</accession>
    <name>A0A401QFD4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01049073">
        <property type="protein sequence ID" value="GCB84027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFD4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="16332" checksum="EB29EAC77086DFB1" modified="2019-05-08" version="1" fragment="single">TSERESTSERESTSESESTSESESTSKSESTSERESRSKRESTSKREYKRESASERQTTSQRGNLSEREHKQKEKKRERTQAREREQKRGRERTQARETEHKQRRDREHKRERIEASEREQKRKRTQARENTSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFH9</accession>
    <name>A0A401QFH9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01055976">
        <property type="protein sequence ID" value="GCB84145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFH9"/>
    <dbReference type="STRING" id="75743.A0A401QFH9"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF10">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-type ATPase A" evidence="2">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="8985" checksum="295B378D960D2594" modified="2019-05-08" version="1" fragment="single">LYLAVTLIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRNGEKFEVNANLLVVGDLVEIKGGDRVPADIRVITSSGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG62</accession>
    <name>A0A401QG62_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01062247">
        <property type="protein sequence ID" value="GCB84375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG62"/>
    <dbReference type="STRING" id="75743.A0A401QG62"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="108" mass="11585" checksum="3C30B14C0B672B1C" modified="2019-05-08" version="1">MESPCADITAYRQGNGLASRKKVLPIVRDLLKAWEGPAGVCRAWGERLAEEACRDEEGCLPPTPMNSLVEGCPLDAGLPKLTPEAILEKFNKMATEGPLSDSTSPDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG86</accession>
    <name>A0A401QG86_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01061785">
        <property type="protein sequence ID" value="GCB84317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG86"/>
    <dbReference type="STRING" id="75743.A0A401QG86"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="62" mass="6706" checksum="F4894537994DC1DE" modified="2019-05-08" version="1" fragment="single">SHRFCDRVQDPYSLRCCPQVHGVVNDTIAFVKTILVTEMNSATDNPVSFSEANCSAATGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGS0</accession>
    <name>A0A401QGS0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01086523">
        <property type="protein sequence ID" value="GCB84628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGS0"/>
    <dbReference type="OMA" id="KEWRGIE"/>
    <dbReference type="OrthoDB" id="7689696at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="221" mass="26812" checksum="14300C6FC454C8B6" modified="2019-05-08" version="1">MVRKREREQGMERKRKSPQGMGRKRKSPQGMERKSESAHGMERKRSSPQGIGRKREREQGMERKRERAGNGEEEKEPARNGEEERDHARNGEEEKERTRNGEDEREHTSNGEEERERARNGEEEKEYARNGEEERVCKEWRGRERARKEWRGRERARKEWRGREQARKEWIGREKVHKEWRGIERARKEWRGIESAQGIERKRESTQGMERKRKSPQGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH57</accession>
    <name>A0A401QH57_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein MutS clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0025269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01080620">
        <property type="protein sequence ID" value="GCB84673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH57"/>
    <dbReference type="STRING" id="75743.A0A401QH57"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000013">
        <property type="entry name" value="mutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="3">
        <location>
            <begin position="2"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein MutS clamp" evidence="2">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB84673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32430" checksum="1697989EC92C69A5" modified="2019-05-08" version="1">METINTRLDCVQELLEDEDLFFSLQSVISLFLDTDQLLSVLVQIPKQDTVQAAESKITNLIYLKHTLELVEPLQGTLKTCKTPLLKAYCSSLADSRFNLILEQIKTVINDDTRYIKGCLNMRTQKCYAVRPNINEFLDIARRTYTEIVDDVAGMITQLGEKYNLPLKTSFSTTRGFFIQLSSEGASFPNGQLPSEFMKVTVMKNTYNFTTADLIKMNERCQESLREIYHMTYLVVCKLLSEIYKHIHCLYKLSDAVSMLDMYNFRLRQGCFLFFLLQVTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI06</accession>
    <name>A0A401QI06_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01114387">
        <property type="protein sequence ID" value="GCB84990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI06"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="88" mass="9126" checksum="E3BFD82326DD4652" modified="2019-05-08" version="1" fragment="single">GYDLECDAAVSGYDLECAAAVSGYDLECAAAVSGDDLELLLHAAVSDYDLECDTAVSGYDLECAATVSGYDLECDAAVNGYDLDLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI53</accession>
    <name>A0A401QI53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0025751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01122671">
        <property type="protein sequence ID" value="GCB85064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI53"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018964797" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9780" checksum="35D9A409EFDE92C7" modified="2019-05-08" version="1">MKRELRLALGHLLVFAPPAVVAADTRLHLELRLMLPCLSRTVRVPPPDRRASALLQSTLRTDFAEANRTEEEQERQRDNYKSAGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIK5</accession>
    <name>A0A401QIK5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01129331">
        <property type="protein sequence ID" value="GCB85201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIK5"/>
    <dbReference type="OMA" id="EHAKVEH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="21263" checksum="3018CB35573191DE" modified="2019-05-08" version="1" fragment="single">MCSSVESVAVERAAAESAAVERAEVESVAVESVAVESVAVESAAVESAAVEHAKVEHAAVEHAAVMIVAVESAAVECAAVKSAAVESAAVQSAAVESAAVESAAVERAAAESAAMESVAVEHAEVEHAAAASVAVEHAAAESVAVEHAAVESAAVERAAAESAVAESAAAQSAVAGSAAAESAAAESVAVDSAAMEGAAVESAAAESAATESAAAESAATESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL19</accession>
    <name>A0A401QL19_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01233259">
        <property type="protein sequence ID" value="GCB86070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL19"/>
    <dbReference type="STRING" id="75743.A0A401QL19"/>
    <dbReference type="OMA" id="LRFTWAL"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="26484" checksum="F9A842BAEB05E03F" modified="2019-05-08" version="1" fragment="single">MPRLAWALIRFAWALLQFSWALPQLAWALLRFTWALPQLACALLRFTWALLQLACALLRFTWDLLQLAWALIRFAWALLQFAWALPQPTWALLHFAWALPQLTWALLQFAWALLRFAWALLQFAWALLRFAWALLRFAWALPQLACALLRFTWALLRFAWALPQLAWALLQFAWALLRFAWALPQLAWALLRFTWALLRFAWALPQLAWALLQFAWALLQFAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLN5</accession>
    <name>A0A401QLN5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01267091">
        <property type="protein sequence ID" value="GCB86290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLN5"/>
    <dbReference type="OrthoDB" id="8962558at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="8941" checksum="69463ECD19B3F48C" modified="2019-05-08" version="1" fragment="single">DSLTPDVSPDSLTPDVSPDSLTPDVSPGSLTPDVSPDSLTPDVSPDSLTPDVSPDSLTPDVSPDSLTPDVSADSLTPDVSADSLAPDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPD1</accession>
    <name>A0A401QPD1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01442459">
        <property type="protein sequence ID" value="GCB87261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPD1"/>
    <dbReference type="STRING" id="75743.A0A401QPD1"/>
    <dbReference type="OMA" id="CSVYRIN"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="175" mass="20814" checksum="00BE6656ACB1D534" modified="2019-05-08" version="1" fragment="single">EISLDSEIRLDSVIRLDGEIRQDSEIRLVSEIRRDSVIRADSEIRQDSEIRRDSVIRVDSEIRQDSEIRWDSEIRVDSEIRRDSVIRVDSEIRQDSEIRLESEIRRDCVIRADSEIRQDSEIRMDSEIILDSEIRLDGEIRLDSEIRLDGEIRLDRVIRLEDEIRLDGEIRLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGE1</accession>
    <name>A0A401NGE1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003621">
        <property type="protein sequence ID" value="GCB59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGE1"/>
    <dbReference type="STRING" id="75743.A0A401NGE1"/>
    <dbReference type="OrthoDB" id="5982442at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="396" mass="46361" checksum="E225D6723FA094FC" modified="2019-05-08" version="1">MESRYRASLEEVDGELFLVREELQKVWDMLHIRNSELEEQHQELESARGQVDYWMVKSSLMTVGNGPKYTYTECSSENQRLEFLVTSLKQQISEKEQALRQLGRLRNTEKTELEIKISSLELKLAEVDVLEEIRQQRSHGEESEKQQSCPLQKCTRCDSFLEQMSTKLQDYSAKNSELQEERNTALKSLNDVQVLTQGLEETMKLEEQFSQTLQRENQSFSRCSRLMTDQLATLVNEQEDLTKVYKKLPENRKGNASLEYWAPRSHLVQNVVEMVKSQEGQQLQLEEENQRLKEAQGFLSFQKLEEEIHSLQRHLDSKTEKMSTMACEMEALREKNECLMKANVKDWQQVQSLREQMTVTFHKVAYRLVREVVENVVFLPNLPTCIKHELIQNATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH18</accession>
    <name>A0A401NH18_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004911">
        <property type="protein sequence ID" value="GCB60094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH18"/>
    <dbReference type="STRING" id="75743.A0A401NH18"/>
    <dbReference type="OrthoDB" id="9061538at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="127" mass="14376" checksum="8B4E421B3C1DC8B1" modified="2019-05-08" version="1">MYLFFGNKTSVQFLNFTLNLSCPGELQNELNVQAKPVEPVVEGWNPTVRHRCIASHYAQARRLCRSDYAHYCLNSSEDSYIATFFGSESGKPLPMSLLLGVYTSRASFPTLCRPNSSWIYKEPDMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHE5</accession>
    <name>A0A401NHE5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0012711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tropomyosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006225">
        <property type="protein sequence ID" value="GCB60288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHE5"/>
    <dbReference type="STRING" id="75743.A0A401NHE5"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000004">
        <property type="entry name" value="tropomyosin alpha-1 chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB60288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28858" checksum="781BC02368947DAB" modified="2019-05-08" version="1">MSGSNSATIDTVKRKIQFLQQQADEAEEKAEQLQRELDSERQARERAEADVSSLERRIHLVEDELDRTRERLTVTLQKLDEAEKSADESERGMKVVESKVLKAEEIMEMQEVQLKEAKHIAEDADRKFEEVARKLVILEGEQERTEERADQSESKCAEIEEELRNVTNSLKSLEAQTEKYASKEDKYEDEIKLLTDKLKEAETRAEFAERSVAKMEKAIDDLEEKLAKAKEENVGIHQVLEQTLVDLSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHS9</accession>
    <name>A0A401NHS9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0012738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006247">
        <property type="protein sequence ID" value="GCB60423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHS9"/>
    <dbReference type="STRING" id="75743.A0A401NHS9"/>
    <dbReference type="OMA" id="CRLFFSQ"/>
    <dbReference type="OrthoDB" id="15717at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="11977" checksum="25B0F946BBEB1681" modified="2019-05-08" version="1">MRSQWYCSPATGGKTAVIAARHPFEAELEAAKRYAWCACGYSKKQPFCDGTHKTVPSAPEPLRFKLEEAKKVWLCGCKQTKNPPYCDGTHKEDWIQQAAVYASPPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIS0</accession>
    <name>A0A401NIS0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase 48</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0009233</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01003713">
        <property type="protein sequence ID" value="GCB60781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIS0"/>
    <dbReference type="STRING" id="75743.A0A401NIS0"/>
    <dbReference type="OMA" id="KELKIQX"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02668">
        <property type="entry name" value="Peptidase_C19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000029">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 48 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033841">
        <property type="entry name" value="Pep_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="50"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="17">
        <location>
            <begin position="423"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="15">
        <location>
            <begin position="841"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="576"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB60781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="930" mass="106728" checksum="A83A8592C5324979" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJB1</accession>
    <name>A0A401NJB1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002438">
        <property type="protein sequence ID" value="GCB60955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJB1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9625" checksum="D413E41A72021B65" modified="2019-05-08" version="1">MKSKYDDFFLNSMLAAVNSGMGMKGFKKEFPMKDAIYAAAYAWNTLDKETLAQRVAYDYVQCSKKLLCQKPLLFDKDKTCYVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJZ3</accession>
    <name>A0A401NJZ3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005060">
        <property type="protein sequence ID" value="GCB61180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJZ3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="8810" checksum="B177DC6803EE7EA2" modified="2019-05-08" version="1">MDKQVNQCHPVFLEVRSPGRVINCAQCSVGAVVSPPIGRQHWRGRADYNPQRAERALLPGPPWAGGGGCSSEYYAGFEQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKB6</accession>
    <name>A0A401NKB6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0004074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001174">
        <property type="protein sequence ID" value="GCB61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKB6"/>
    <dbReference type="STRING" id="75743.A0A401NKB6"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB61305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="364" mass="41481" checksum="7E78AAC21D064FC6" modified="2019-05-08" version="1" fragment="single">MVDLKAVSPCNMGKAAFNTGRIFWLPYHKVKMSTVEKQYSGKPQANLQDQLQNCDLPFNRQFQRPTSRIPSKKDRLAEAKRLDSLGEHLKLSKTDINIYRNTYKHNICLDMLRQGYHKSFSEFTNLILNWNNVREAAGPGSDIWMEEPLDKQHNKLDHLQYFLIRAEAARRAAHFEEVYNNQLSLACYFKTVGDKLLSDHFFQSCLTTAEMITPAGGQKVAEANANMGMAFEEKGQLDKAAEHYEIFQQLTMGTTWQDENGCCHFAQACANLWRIYTSLADEYLENEQYKEANKSLRKAFDIAKEGGDKKMELAALYRVALGYLSSGDPDIAIGYLQMYLELSNSMDDDIGLGKTYEALAKALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLQ8</accession>
    <name>A0A401NLQ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein amnionless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0009406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003836">
        <property type="protein sequence ID" value="GCB61831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLQ8"/>
    <dbReference type="STRING" id="75743.A0A401NLQ8"/>
    <dbReference type="OMA" id="NALYKQW"/>
    <dbReference type="OrthoDB" id="10067964at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026112">
        <property type="entry name" value="AMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995">
        <property type="entry name" value="AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995:SF2">
        <property type="entry name" value="PROTEIN AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14828">
        <property type="entry name" value="Amnionless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019033208" description="Protein amnionless" evidence="11">
        <location>
            <begin position="19"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB61831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="479" mass="53380" checksum="8F6F1D065A661783" modified="2019-05-08" version="1">MRSAHFISFSLFFQVSGALYRQWIPDTNFNNATNWDKGRIPCENDRVQFLRDQSVSVLVQSPLNLMEMYMPLDGEIILSHGAGFAASDGQSESGCKRGEDITFKDPNQYKWYDPKYWHTALSMSDLENEKYLFTLDEEGVPCQYDDVIFRPGTSFRVDLDSDIQIINVKTISIMNRKFASNDEFAEHQWSNTGKLQFQGNGSIAVTNTKCEDKSGCECGNFDNHRRICSNLQQGSENHFPGLLCTSPLKPQGHCSKVCGAIIYLEYGPQFDLESYRAQLGFSFLGLKYEGVQMSVTKVYKKQSSKKIIPTDAVPRIQIVLIDEVKSAPGTLAAELAEEIMEDITSRGDTFGIINAELRKSSNSEDQFGGNMNAGKIVGIVAGAFIAALLIGNLIYLIASGRIRAKISSAVIKFRKYNQFENEEAADQGFRNVVYGSSVHLSPDSNDLYSGENTITIVTGQSGTNFANPLFEQDFNEESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM45</accession>
    <name>A0A401NM45_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003850">
        <property type="protein sequence ID" value="GCB61955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM45"/>
    <dbReference type="STRING" id="75743.A0A401NM45"/>
    <dbReference type="OMA" id="GPNQYKF"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9492" checksum="5AD6603E3CBED17B" modified="2019-05-08" version="1">MLGLMFRHAKSHKGLIPLFVFIGAGSIGATMYLLRLALRNPDVSWNHKNNPEPWNDIAPNQQYKFFAVNMDYSKLKKNRPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN14</accession>
    <name>A0A401NN14_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Collagenase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Matrix metalloproteinase-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0014466</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="21">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007773">
        <property type="protein sequence ID" value="GCB62244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN14"/>
    <dbReference type="STRING" id="75743.A0A401NN14"/>
    <dbReference type="OMA" id="ISAFRYI"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF165">
        <property type="entry name" value="COLLAGENASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0177">Collagen degradation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 23" id="KW-0732">Signal</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019204720" description="Collagenase 3" evidence="23">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="24">
        <location>
            <begin position="106"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="22">
        <location>
            <begin position="278"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="22">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="22">
        <location>
            <begin position="376"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="21">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="176"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="20">
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            <position position="229"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <note>catalytic</note>
        </ligand>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <note>catalytic</note>
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            <position position="288"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
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        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
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        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="429"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
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        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB62244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="468" mass="53673" checksum="C093DE48E13EC9B4" modified="2019-05-08" version="1">MKYFQAPILLILLNSTFTFAFPLTSEISQNDHSFAKQYLKRLYDFEGDPFNGLKTSSGDSIRANILKMQKFFGLPITGELDSATLVVMKRPRCGVHDALQYNHFPGNIKWQHTNLTYRITKYTPDIENRQVDRAIWAAFKVWSDVTPLTFTRALDGEADIMMSFTPRVHGDGYPFDGPNGFLGHAFPPGRGLGGDVHFDEEETWSMDSKGYNLFMVAAHEIGHALGMAHSQDVGALMFPQYSYLNIRDFSLPYDDVQGIQALYGSSNKPDTKPHPKTPEKCDPSLSFDAVSKLRGEIMFFKDRFLWRIHPQVPDAMMLTIQTQWPDLPSKIDASYENAFRDITLFFRKKKYWAVNGYDILPGHPRSIYDFGFPKTVKKIDAAVQIKETGKTIFFVGNKCWSYDERAKKMDKGYPKWIEDDWPGIGDNVDAVVQHREHVYFFRGFTMSVYNNRNKRVINIVYANSAICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN27</accession>
    <name>A0A401NN27_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0000022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000003">
        <property type="protein sequence ID" value="GCB62308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN27"/>
    <dbReference type="STRING" id="75743.A0A401NN27"/>
    <dbReference type="OMA" id="DFGWRSE"/>
    <dbReference type="OrthoDB" id="9934301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007158">
        <property type="term" value="P:neuron cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040685">
        <property type="entry name" value="Annexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045574">
        <property type="entry name" value="ASTN1_2_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040510">
        <property type="entry name" value="ASTN_2_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026995">
        <property type="entry name" value="Astrotactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16592">
        <property type="entry name" value="ASTROTACTIN-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16592:SF2">
        <property type="entry name" value="ASTROTACTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18411">
        <property type="entry name" value="Annexin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19743">
        <property type="entry name" value="ASTN1_2_fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18577">
        <property type="entry name" value="ASTN_2_hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Astrotactin-1/2 Fn3" evidence="3">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Annexin-like" evidence="1">
        <location>
            <begin position="84"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Astrotactin-2 C-terminal beta-hairpin" evidence="2">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26379" checksum="7389036D533D743B" modified="2019-05-08" version="1">MAAVECIVDCGRGESLSFADDLLSGLGSSCVVVGKNHGVASETTTYSLIFKCLEPDSFYKFTLYALDSRGRRSEPSTVTMRTSCPLIDDIKAEEIAETIYSLFNGYTSGKEQQTAYNILMEISSPMVYRVIHHYNSHYEKFGDFGWRSEDELGPRKAHLILKRLDNVSDRCASLLHSAYIQSHTDSVLYFICRMEETRPTGMVWYSTLHDAKVTCDEKLMSVPRNIYGDTKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN84</accession>
    <name>A0A401NN84_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0009496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003888">
        <property type="protein sequence ID" value="GCB62287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN84"/>
    <dbReference type="STRING" id="75743.A0A401NN84"/>
    <dbReference type="OMA" id="ERTKIHR"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001335">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="177" mass="20329" checksum="498FE343E2C5277D" modified="2019-05-08" version="1">MDIQVIGTKTVKLKMLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRQTRPETARPRPKGLGEDRPARLRGEADRDTYRRTAPLGSDKKAEAGAGAATEFQFRGGFGRGRGQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNW0</accession>
    <name>A0A401NNW0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Josephin-1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Josephin domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Josephin domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Josephin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0009534</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with beta-actin/ACTB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01003913">
        <property type="protein sequence ID" value="GCB62546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNW0"/>
    <dbReference type="STRING" id="75743.A0A401NNW0"/>
    <dbReference type="OMA" id="NCSPLMN"/>
    <dbReference type="OrthoDB" id="422700at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.40:FF:000003">
        <property type="entry name" value="josephin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040053">
        <property type="entry name" value="JOSD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291">
        <property type="entry name" value="JOSEPHIN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291:SF1">
        <property type="entry name" value="JOSEPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="21">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00077222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB62546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="199" mass="22876" checksum="12CF3A45346E94DB" modified="2019-05-08" version="1">MNCVPWKGDKLKVDSDAPVPALIYHEKQRRELCALHALNNVFQDGRAFTRDSLQEIFQRLSPNTMVTPHKKSMLGTGNYDVNVIMAALQTKGYEAVWWDKRRDVNTIALSNVMGFIMNIPSSLCWGPVKLPLKRQHWIGVRDVAGIYYNLDSKLKLPDQIGNEDELRKFLKHQLRGKNCELLLVVSEEVEVRQSWRTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ98</accession>
    <name>A0A401NQ98_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rab3-GAP regulatory subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0007334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002633">
        <property type="protein sequence ID" value="GCB63081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NQ98"/>
    <dbReference type="OMA" id="SWCGELE"/>
    <dbReference type="OrthoDB" id="2019917at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029257">
        <property type="entry name" value="RAB3GAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14656">
        <property type="entry name" value="RAB3GAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="5">
        <location>
            <begin position="89"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="6">
        <location>
            <begin position="783"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1398" mass="156442" checksum="E294136DAD33D536" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQA7</accession>
    <name>A0A401NQA7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Stonin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0013146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Stoned B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006600">
        <property type="protein sequence ID" value="GCB63019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQA7"/>
    <dbReference type="STRING" id="75743.A0A401NQA7"/>
    <dbReference type="OMA" id="EWVSFND"/>
    <dbReference type="OrthoDB" id="10063141at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000018">
        <property type="entry name" value="stonin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012320">
        <property type="entry name" value="SHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017110">
        <property type="entry name" value="Stonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022699">
        <property type="entry name" value="Stonin2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12016">
        <property type="entry name" value="Stonin2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037099">
        <property type="entry name" value="Stonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51070">
        <property type="entry name" value="SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SHD" evidence="8">
        <location>
            <begin position="557"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="694"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114845" checksum="5B78BDABAAEA6260" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQT0</accession>
    <name>A0A401NQT0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="17">3.1.2.2</ecNumber>
            <ecNumber evidence="6">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0013171</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:84099"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74410"/>
            <dbReference type="ChEBI" id="CHEBI:233601"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:84103"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:233604"/>
            <dbReference type="ChEBI" id="CHEBI:233605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="17"/>
    <dbReference type="EC" id="3.1.2.22" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01006625">
        <property type="protein sequence ID" value="GCB63207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQT0"/>
    <dbReference type="STRING" id="75743.A0A401NQT0"/>
    <dbReference type="OMA" id="QRCPPAV"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000098">
        <property type="entry name" value="palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019221673" description="Palmitoyl-protein thioesterase 1" evidence="22">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00093191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00093223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB63207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="308" mass="34978" checksum="522F6DC8A27352BB" modified="2019-05-08" version="1">MAPLAAGCLLLLFSFCSVRRTAASWNTSRNLTEPTPVVIWHGMGDSCCNPLSMGFIKKLVEQEIPRIYVLSLEIGNTITEDMENSFFMNVNDQVALVCNILSKDKKLQDGYNAMGFSQGGQFLRAVAQRCPSPAMVNLITFGGQHQGVYGLPHCPGVSSHICNWIRKMLNLGAYSSPIQEHLVQAEYWHDPLNEDLYRNKSIFLADINQERGINESYKENLMKLKKFVMVKFSSDTMVDPVDSEWFGFYKAGQAKETYTLKESVLYQEDRLGLKAMDKVKKLEFLTANGDHLQFSEEWFIKNIVPYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS12</accession>
    <name>A0A401NS12_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0004461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001322">
        <property type="protein sequence ID" value="GCB63637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS12"/>
    <dbReference type="STRING" id="75743.A0A401NS12"/>
    <dbReference type="OMA" id="NIRWHYE"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055130">
        <property type="term" value="P:D-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:L-proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000004">
        <property type="entry name" value="D-amino-acid oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF15">
        <property type="entry name" value="D-AMINO-ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="10">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>D-serine</name>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>D-serine</name>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB63637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="305" mass="34567" checksum="76BF3CFDB521C257" modified="2019-05-08" version="1">MHVAVIGAGVIGLSTAQCIINRFHSIVKPLTIVVYADKFTPQTTSDGAAGLWQPYVHDRGILEEVKWNKETFDYLLSYVNSPDANEMGLFLQSGYNIFKGQVPVDPSWKDAVLGFRHLTDEELKLFPGFSSGWFHTTLILEGKSYLPWLMERLKEHGVQFVQKKITSFQELSPDFDVIVNCTGIRAQELQPDPELIPARGQVIKVYAPWIKHFILSNDDTTTIYSMPYIIPGSKLVTVGGIFQLGNWNEENDSEDHKRVWEGACKLVPSLKNARIVEDWTGLRPCRNRVRIERQTINAGAEKFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSP5</accession>
    <name>A0A401NSP5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Intersectin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001339">
        <property type="protein sequence ID" value="GCB63928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSP5"/>
    <dbReference type="STRING" id="75743.A0A401NSP5"/>
    <dbReference type="OMA" id="CEFKVHL"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08375">
        <property type="entry name" value="C2_Intersectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13264">
        <property type="entry name" value="PH_ITSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000011">
        <property type="entry name" value="Intersectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000069">
        <property type="entry name" value="Intersectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000029">
        <property type="entry name" value="Intersectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF9">
        <property type="entry name" value="INTERSECTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="225"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="342"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55527" checksum="92D57284F52870ED" modified="2019-05-08" version="1">MAQYIVGKAAGVAHQFYKSCKLVLVFQKPLLESDLLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGERMPVKMIGDILTAQLPHMQPYIRFCSCQLNGAALIQQKTDEVPEFKEFVKRLAMDPQCKGMPLSSFLLKPMQRVTRYPLIIKNILENTPENHPDFSHLKQALEKAEELCSQVNEGVREKENSDRLEWIQTHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQIIKPLGYSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNIVEGIELKACRSNGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIKDLEQDVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVAKRLLLHEVPTGEIVVRLDLQLFDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTK6</accession>
    <name>A0A401NTK6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pyruvate kinase</fullName>
            <ecNumber evidence="5">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0014740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01008026">
        <property type="protein sequence ID" value="GCB64223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTK6"/>
    <dbReference type="STRING" id="75743.A0A401NTK6"/>
    <dbReference type="OMA" id="MAIFYTK"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="14">
        <location>
            <begin position="52"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB64223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="172" mass="18931" checksum="141B1A8E1BDB7A3B" modified="2019-05-08" version="1">MLSGETAKGDYPLEAVKMQHLIAREAEAAMYHRQMYSEIAHLAPPTVDPTETAAIGAVQASFKCLAAGIIVLTKSGRSAHLVSRYRPRAPIIAVTREAQTARQAHLYRGIFPVIFRQPTDAVWSDDVDHRVNFAMEVGKSRGFFKSCDLVIVLTGWRPGPGSTNTMRVLQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTN2</accession>
    <name>A0A401NTN2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001357">
        <property type="protein sequence ID" value="GCB64236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTN2"/>
    <dbReference type="STRING" id="75743.A0A401NTN2"/>
    <dbReference type="OMA" id="LFPHYLA"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026771">
        <property type="entry name" value="Tmem218"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31622">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31622:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9373" checksum="D5C8ABFBC4EDDD43" modified="2019-05-08" version="1">MTSWLSTVFVFFLALILTAILIFFPRTKEIPEPVTEDVIYDTFFIGRYSLLCVLIVALLISLILLFPHYLAEHVEAKLIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU83</accession>
    <name>A0A401NU83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0014764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01008050">
        <property type="protein sequence ID" value="GCB64417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU83"/>
    <dbReference type="STRING" id="75743.A0A401NU83"/>
    <dbReference type="OMA" id="FAYIEGQ"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF47">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="255"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB64417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="508" mass="55278" checksum="5CD28081DA05BCB3" modified="2019-05-08" version="1">MFYGKRYLELMEQVIKGGGEKAILRHTQRNKKLLVRERLQLLLDKEETLELSPFAGFGMPYGDIPAAGCLTGIGKINGVWCVFIANDATIKGGTAYPITVKKQLRAQNIAIQNRLPCIYLVDSGGAFLPLQADIFPDKNHGGRMFYNEAVMSAVGIPQVAVVCGSCTAGGAYIPTMVEETVMVDSIGTIFLAGPPLVKAATGEDVSPEELGGATLHAKVSGCIDHFAATEEEAYECARNIIATLNFDLPPHKTTNFEEPLYTAEELNGLAPKDYAHTLSIKLVLSRLTDGSRFLEFKALYGTTLVTGFAQIKGHLVGIVANNGELTHNAALKGSHFVQLCDQRGIPIIFLQNTRPNVTMAGTLSKAEDVTNQLKAQGSMMAAVACATVPKITIIIGGCYGGESFPMCGRSFDPNFLFLWPNAKVGLVGPNYCSEIQEPDGQNQDEAQLKIMKERLENESSAFHSSSRVWDDGVILPKDTRMVIGQCLNIIKQKPRLHSQPERRAVLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU95</accession>
    <name>A0A401NU95_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM76B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004099">
        <property type="protein sequence ID" value="GCB64412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU95"/>
    <dbReference type="STRING" id="75743.A0A401NU95"/>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF1">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7924" checksum="DB6B1F499D28F034" modified="2019-05-08" version="1">MAALYACTKCHQRYPFEDLSQGQQLCKECRIAHPVVKCTYCRTEFQQESKTNTICKKCAQNVKQFGTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWJ5</accession>
    <name>A0A401NWJ5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001425">
        <property type="protein sequence ID" value="GCB65243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWJ5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7812" checksum="7CC0D4CEBCCD7132" modified="2019-05-08" version="1">MSRDHQKWDAVHSGHYQEELAGLVETAVHEAGCRVHYFYNRAVEYRKALGVEPRRKSFEQVLNALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWL7</accession>
    <name>A0A401NWL7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006862">
        <property type="protein sequence ID" value="GCB65271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWL7"/>
    <dbReference type="STRING" id="75743.A0A401NWL7"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="16762" checksum="00C7197A3F70DF86" modified="2019-05-08" version="1">MSDDSGDEEPTSQSDKSELHATLRTLANKLDDLSQCNDLIAKHGAALQRSLSELESLKLPAESGEKIKAVNERATLFRITSNAMINFAAEVGHMHQSVAATLLLPAVAIQARAMLFNPEPGMVSVEGTAITSMGHTVWRSHPHRQFSTARGVQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYP3</accession>
    <name>A0A401NYP3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BUB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0011938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005615">
        <property type="protein sequence ID" value="GCB65991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYP3"/>
    <dbReference type="STRING" id="75743.A0A401NYP3"/>
    <dbReference type="OMA" id="KTLCPNP"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF25">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="3">
        <location>
            <begin position="47"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB65991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1098" mass="123762" checksum="90591323DBD862BD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYT9</accession>
    <name>A0A401NYT9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0004898</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01001478">
        <property type="protein sequence ID" value="GCB66072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYT9"/>
    <dbReference type="STRING" id="75743.A0A401NYT9"/>
    <dbReference type="OMA" id="FFAYMYF"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF16">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB66072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="444" mass="51208" checksum="2E2AD51E4AE4A4EB" modified="2019-05-08" version="1" fragment="single">EVDVDDKAGLEVDGDLDLKSDSDIPDVPASNDSTPEVFNKALSGLSSRWKNWWIRGILSLAMISFFFLIIYLGPIVLMFVVLYVQIKCFHEIITIGYRVYHSYELPWFRTLSWYFLLCVNYFFYGETVADYFGGLVRREVPLQFLVRYHRFISFAMYLAGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIIVTQSHLVIQNLFEGMIWFIVPISIVICNDIMAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGFLFAYTLSSYNYFVCPVDYNSETNSFIVDCEPSLLFHLQEYMLPSVLQSALGWETVHLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKASIMIRLVMLFVAEYNDFADTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLHIYNVLKSQLVERGALQPAISEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P133</accession>
    <name>A0A401P133_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0000646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components. Interacts with DDI2. Interacts with TASOR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000125">
        <property type="protein sequence ID" value="GCB66829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P133"/>
    <dbReference type="STRING" id="75743.A0A401P133"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="79"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="267" mass="31004" checksum="63417DF8F0888AF5" modified="2019-05-08" version="1">MAGPLEQAVGMLELLRSEWSRKNPNLRKCEELLGKLKVTLLELNFLPTSGTKLTKRQLILARDVLEIGAQWSILKKDIPSFERYMAQLKCYYFDYKDELPESAYKHQLLGLNLLFLLSQNRVAEFHTELERLPARDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYENILFSEASRTLFFTAPKKMTEYAKKRGWLLGPDNYYSFTSQQQKPEEVTIPSTELAKQVIEYARHLEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P151</accession>
    <name>A0A401P151_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004323">
        <property type="protein sequence ID" value="GCB66841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P151"/>
    <dbReference type="STRING" id="75743.A0A401P151"/>
    <dbReference type="OMA" id="METRNSE"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16569">
        <property type="entry name" value="RING-HC_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000162">
        <property type="entry name" value="E3 ubiquitin-protein ligase SHPRH isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000786">
        <property type="entry name" value="E3 ubiquitin-protein ligase SHPRH isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048695">
        <property type="entry name" value="SHPRH_helical_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21324">
        <property type="entry name" value="SHPRH_helical-2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="313"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="392"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64272" checksum="DBE8027B13548621" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P211</accession>
    <name>A0A401P211_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0008004</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with KCNMA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002996">
        <property type="protein sequence ID" value="GCB67166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P211"/>
    <dbReference type="STRING" id="75743.A0A401P211"/>
    <dbReference type="OMA" id="WVHLEDE"/>
    <dbReference type="OrthoDB" id="4691307at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099104">
        <property type="term" value="F:potassium channel activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000015">
        <property type="entry name" value="Leucine rich repeat containing 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051432">
        <property type="entry name" value="KCNMA1_auxiliary"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473:SF6">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="15">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB67166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="283" mass="31676" checksum="1AB8C04D02247B4E" modified="2019-05-08" version="1">MLAAACPPKCTCSQFKVDCKGIALTMFPTPLQLDTRHLNLASNDIAEIDSLQLSLLSDLVHLDCSHNKISEISKLHFLSVVKLVYLDLSHNRLRNLGESTFTPLTNLVILKLNGNKDLKELDDGIFANNVGLQEINLSNNGLLYLNTSSIKSLQGLKAVYLAGNPWDCQCPISQLSEWIFKHNKSFPDEANTFCTSPKSMVGIRVSKALVKIFEVCHTPLGYFDYFFFVIVGFAIFISGIIVASLTGAILVFFERKKMFTDEEDIDMKQYRSNRVVVRLSKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P258</accession>
    <name>A0A401P258_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="16">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0013670</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:78372"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="16"/>
    <dbReference type="EMBL" id="BFAA01007083">
        <property type="protein sequence ID" value="GCB67190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P258"/>
    <dbReference type="STRING" id="75743.A0A401P258"/>
    <dbReference type="OMA" id="SCYIGCG"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF4">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="18">
        <location>
            <begin position="59"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="17">
        <location>
            <begin position="229"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB67190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="401" mass="42649" checksum="C3E1C06B1B3E1EA7" modified="2019-05-08" version="1">MQQIAVCAELRVLDFAADPLNPGGLATPTHPTINCKAAVAWEAGKPLCIEVVEVAPPKAHEVRIKIIATAVCHTDAYTLSGSDSEGVFPVILGHEGAGIVESIGEGVTCVKAGDRVIPLYIPQCGECKFCLNPNTNLCQKIRLTQGHGLMPDKTSRFTCKGQQLYHYMGTSTFSEYTVVADISLAKIDNAAPLDKVCLLGCGISTGYGAAVNTAKVAPGSSCAVFGLGGVGLATIMGCHVAGATRIIGVDINNDKFARAKEFGATECVNPKDYEKPIQEVLVGLTDGGVDYSFECIGNVTTMRAALEACHKGWGTSVIIGVAPSGHEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVKEYMDKKIKVDEFVTQTLAFDQINESFELLRKGKSIRSVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2H6</accession>
    <name>A0A401P2H6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004371">
        <property type="protein sequence ID" value="GCB67359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2H6"/>
    <dbReference type="STRING" id="75743.A0A401P2H6"/>
    <dbReference type="OMA" id="QLEFLMF"/>
    <dbReference type="OrthoDB" id="6235974at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="136" mass="14683" checksum="17F56C0B4A62C4F9" modified="2019-05-08" version="1">MRFLRRTFGRRSVRRYMSERDGGRGGGNSGAREPATVAGAGVRSATPVPTGTMVHIPAAGNSKSVLTCRVQLLDGTDVSVELPVTSPSLRLAPAEMSGYCLPPVIWNSRSSFLPLLWALANLSIQSLHQLEFLMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4X0</accession>
    <name>A0A401P4X0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0015197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008499">
        <property type="protein sequence ID" value="GCB68158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4X0"/>
    <dbReference type="STRING" id="75743.A0A401P4X0"/>
    <dbReference type="OMA" id="CHCENAS"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015125">
        <property type="term" value="F:bile acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF87">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB68158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="418" mass="46290" checksum="15729724A6E49D0F" modified="2019-05-08" version="1">MWRYRRWTYNTRLKPNRSYPFAVWKSALGGSMVAGIPDSSELRFIGLYPILLLPKRNAQGGFPLILLRTLRCSVYLLVVLAQVCMSALMSGLTVFIGKFLEQQFSVTASFANLLVGSIHVPGAVLGILIGGAILRKFQISLRGSAVMCFMAIFVSICVTTPLLFLGCSTQNIDGLTFNLNSSNGSSGIDLSCNRGCSCRDQAYNPVCTTDGIEFISPCHAGCRNATFGFAGKVVNYTNCSCVSTQALVKPGTCGSGCYRLLLPFMFFLTLTAFVATLCQTPSFMLVLRSVKPEDKSFAIGIQFMLFRVLAWLPGPILYGSMIDTTCIRWEKKCNKKAACRYYNLDLFRVRYIGLQMLFECGAFLFFLVAYYVLVKDLLRKEQRGGVKAKTSIDPEVGGERKILMEKENGMKAQLELKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P543</accession>
    <name>A0A401P543_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 254</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0008198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003094">
        <property type="protein sequence ID" value="GCB68265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P543"/>
    <dbReference type="STRING" id="75743.A0A401P543"/>
    <dbReference type="OMA" id="IMYKGWW"/>
    <dbReference type="OrthoDB" id="9984821at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028110">
        <property type="entry name" value="TMEM254"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34104">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34104:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14934">
        <property type="entry name" value="TMEM254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB68265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="14295" checksum="6B6729D86F0A22E6" modified="2019-05-08" version="1">MPDTGSGSTYFRRTSLFWMAVITGSFGYFTLLMFWPQSVPYKSLGPWGSFSKYLVDHYHPQLYIGYWMAWALHLAEALYSIKLCSDKGITNVSVQSKWAFQTFLFGITSLWYLLSYEPGRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P611</accession>
    <name>A0A401P611_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003117">
        <property type="protein sequence ID" value="GCB68562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P611"/>
    <dbReference type="OMA" id="SEKNITH"/>
    <dbReference type="OrthoDB" id="8773301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38233" checksum="BF9F9EFDBFF1625F" modified="2019-05-08" version="1">MVCYLPSYEVNWRIFWTIYVTYKDKASTHLTSCFSLDLTTIAQMGCRCCRMVKRYIFEPAIIRELPSNSVKTEKNYRNNEIKHELSFQNRNAKTNNIIASTFDKVINLEEQNVDIIGKEIYVSEKNITHMQEKILEDINDNTDNDTVHVLNNKLVHTGSYTAPEQAEMVHATNTDNCSSNNNSKDTPKDELVQHNDSGTERNCQTLNGPAIQHPTEVENMQEVCEIHQVGGKIIDNNETGIVNNTELSHVLNDEVTQYNLQTDMDEIKSLSNPSSHEEISILNGQKDRDNTPPPIDGEFTKDLLDEVKLKIEGEDPEVEAALAALEAATAGEDDELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6E8</accession>
    <name>A0A401P6E8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0008270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01003132">
        <property type="protein sequence ID" value="GCB68719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6E8"/>
    <dbReference type="STRING" id="75743.A0A401P6E8"/>
    <dbReference type="OMA" id="MNYPTVG"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000008">
        <property type="entry name" value="histidine--tRNA ligase, cytoplasmic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="12">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="60"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB68719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="510" mass="57642" checksum="FB6F37E4CB8AD58A" modified="2019-05-08" version="1" fragment="single">AMAGRAELEAAVREQGVRKLKADKAPQHQISEELAKLLELKAQLGTNDGKPQFVLKTPKGTRDYNPKQMAIREKVFSTIINCFKRHGAETIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLRYGLTVPFARYLAMNKITNIKRYHIAKVYRRDNPAMTQGRYREFYQCDFDIAGQYDPMIPDAECLKIVHEILSELQLGEFLIKVNDRRVLDGMFEVCGVPADKFRTICSAVDKMDKMPWEDVKNEMVSEKGLAPETADKIGEYVQLNGRSELIDKLVQDAKLSQNKVAMEGLNDMKQLFVYLTLYGVEEKVLFDLSLARGLDYYTGVIYEVVLTQSQAATQTQQNEHSEQVSIGSVAAGGRYDGLVGMFDPKGRKVPCVGVSIGIERIFSIMEQRLEASDEKIRTTETQVLVATAQKNLLEERMKLVAELWKSGIKAEITYKKNPKLLNQLQYCEETGIPLVAIIGEQELKDGVVKLRVVSTREEVDVARENLIEEIEKRTCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6W0</accession>
    <name>A0A401P6W0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0008289</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM131 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003142">
        <property type="protein sequence ID" value="GCB68833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P6W0"/>
    <dbReference type="OMA" id="QMEINGQ"/>
    <dbReference type="OrthoDB" id="168404at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055435">
        <property type="entry name" value="Ig_TMEM131L_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055436">
        <property type="entry name" value="Ig_TMEM131L_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045695">
        <property type="entry name" value="TMEM131-like_Ig_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056311">
        <property type="entry name" value="TMEM131_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055437">
        <property type="entry name" value="TMEM131L_Ig_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022113">
        <property type="entry name" value="TMEM131L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24495">
        <property type="entry name" value="Ig_TMEM131_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19532">
        <property type="entry name" value="Ig_TMEM131L_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24498">
        <property type="entry name" value="Ig_TMEM131L_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24499">
        <property type="entry name" value="Ig_TMEM131L_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24501">
        <property type="entry name" value="Ig_TMEM131L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12371">
        <property type="entry name" value="TMEM131_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1073"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 131-like N-terminal" evidence="9">
        <location>
            <begin position="64"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131 second Ig-like" evidence="11">
        <location>
            <begin position="164"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 131-like second Ig-like" evidence="10">
        <location>
            <begin position="297"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L third Ig-like" evidence="12">
        <location>
            <begin position="391"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L fourth Ig-like" evidence="13">
        <location>
            <begin position="792"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L fifth Ig-like" evidence="14">
        <location>
            <begin position="978"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1140"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1285"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1309"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1480"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1661"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1166"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1333"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1348"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1387"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1406"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1498"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1663"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1685"/>
            <end position="1705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB68833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1705" mass="187452" checksum="F219F52452D158D4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7E9</accession>
    <name>A0A401P7E9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004534">
        <property type="protein sequence ID" value="GCB69033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7E9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="304" mass="35465" checksum="D106AF8F5A57377B" modified="2019-05-08" version="1">MMFHIPRVGEKSTHELLQVNNLGYNGNGVLIKLKNAPEHAIQKADRIYSINLWACKGGGNNWLCPKYAIIMEDYCGYTTYENCTLTVEVNNQTVCDSAQYLINYYIVTSYSNYTKRDIVCELPGHKVVQTNLSDSISIGHHELTPHRYVSIVEADDLERTDDDQRIHRYVQKGLPHFPHLQANREELKKEAIQIDHPWNKERELIKTHAEKAEELFKSQNCFTRIWNWGLNTNIHPWICIISHIVVILQLFILLVFFITLYCLRCRIREWRGDSRRLEKKELLQLLPVDHSTPGPDSNKFSMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P869</accession>
    <name>A0A401P869_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0001039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01000217">
        <property type="protein sequence ID" value="GCB69335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P869"/>
    <dbReference type="STRING" id="75743.A0A401P869"/>
    <dbReference type="OMA" id="WFQLYWL"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF107">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
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    </feature>
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        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
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        <location>
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        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
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        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
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        <location>
            <position position="235"/>
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        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
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        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB69335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="369" mass="40898" checksum="78C46996F4653D7E" modified="2019-05-08" version="1">MPSKPVCINDFEQHAKDILPKAVYDYYRSGADEQQTLMDNVTAFSRWRLCPRVLRDVSKMDLSTTVLGQRINMPICVSATAMQRMAHPEGEVATVKACRSQGTGMMLSTWATSSIEQVAEAAPNAIRWLQLYIYKDREVTKSLVRRAEAAGYRGIFLTVDTPYLGKRLADVRNKFKLPPHLRMANFETLDLAFSKKDYGDDSGLAVYTADAIDSSIKWDDIDWLRQLTKLPIVLKGILRADDAREAVKHGIVGILVSNHGARQLDCVPATIDALAEITEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFLGRPVLWGLAYQGEEGVCDVLQMLKEEFKLALALAGCRSVKEVDKSLVKRSPWVTPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P877</accession>
    <name>A0A401P877_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0005451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001697">
        <property type="protein sequence ID" value="GCB69293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P877"/>
    <dbReference type="STRING" id="75743.A0A401P877"/>
    <dbReference type="OMA" id="IVPHEAM"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="212" mass="23818" checksum="526D86AC2DB63458" modified="2019-05-08" version="1">MNYVESPSRFTAPPPGAEREENLKMEFQAVLMAAGGGSRMMDLTSNIPKPLLLVGNKPLIWYPLNLMERLGFEEVIVVTTREVQKQLPQMDSKMKLDTVCIPEDTDMGTADSLRQIHGKIKTDVLVVSCDLITDAALHEVIDLFRAHDATVSMLMRKAHDFTEPVPGQKGKNKEAEQRDFVGVDDTCKRLLFMANEADLDDELVIRKSLMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9I0</accession>
    <name>A0A401P9I0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine zipper transcription factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LZTFL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001733">
        <property type="protein sequence ID" value="GCB69733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9I0"/>
    <dbReference type="STRING" id="75743.A0A401P9I0"/>
    <dbReference type="OMA" id="QMEGTTA"/>
    <dbReference type="OrthoDB" id="313412at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903565">
        <property type="term" value="P:negative regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026157">
        <property type="entry name" value="LZTFL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21635">
        <property type="entry name" value="LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21635:SF0">
        <property type="entry name" value="LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15294">
        <property type="entry name" value="Leu_zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB69733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="240" mass="27999" checksum="8250270855A4D515" modified="2019-05-08" version="1">MAELGLNEHHQNAVINYMRFARSKRALRLKTVDSCFQDLKDSRLTEDTFTVDEVTEMLDGLKIVVHSEVESELINTAYTNVLLLRQLFCQAEKWYLKLQTDISDLENRELLEQVAEFEKTEFTSSGRKVNSEIIKPKLAPLNEGGVSELLSKEITRLQDENDKLKARLRTVETQATSALEEKLKLEKFLKDLKKVPEDQKELEKKFQETAAYRNMKEILTKKNEQVKELRKRLSQYEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAC1</accession>
    <name>A0A401PAC1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">XRN2-binding (XTBD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0001180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000255">
        <property type="protein sequence ID" value="GCB70042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAC1"/>
    <dbReference type="OMA" id="MEFILCH"/>
    <dbReference type="OrthoDB" id="2359216at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021859">
        <property type="entry name" value="XTBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48430">
        <property type="entry name" value="PARTNER OF XRN-2 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48430:SF1">
        <property type="entry name" value="PARTNER OF XRN-2 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11952">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51827">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRN2-binding (XTBD)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="108" mass="12741" checksum="7B74917ED257F6BF" modified="2019-05-08" version="1">MAGTSLDDFLKRNREMADLSLEELRGLSESDKHWTARRSFLAWNLSHYPRERMDYLVALSMVWANHIFMSCCYSEQLMEKVLEMADGVNVEDAPTFTTRDEIMNKQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC82</accession>
    <name>A0A401PC82_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003360">
        <property type="protein sequence ID" value="GCB70718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC82"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019078384" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15275" checksum="7FC3C01DA4201D0D" modified="2019-05-08" version="1">MLLAVFVVAGTLAFQGVSGRRYRPPIFLEPRECLEFEVLCNVSDFQARSYNSSRWVGVPFPNVSEFRRSFRCLKRYAKGQNSQGLPILMTAQFLVSFNGSRPLSLFWLLPKNRQVNPPLPVNGSRVSTYPISWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD43</accession>
    <name>A0A401PD43_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Link domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001875">
        <property type="protein sequence ID" value="GCB71042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD43"/>
    <dbReference type="STRING" id="75743.A0A401PD43"/>
    <dbReference type="OMA" id="MASTHCH"/>
    <dbReference type="OrthoDB" id="5860362at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03517">
        <property type="entry name" value="Link_domain_CSPGs_modules_1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03520">
        <property type="entry name" value="Link_domain_CSPGs_modules_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000011">
        <property type="entry name" value="Aggrecan core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000002">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000571">
        <property type="entry name" value="Neurocan core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050691">
        <property type="entry name" value="Hyaluronan_bind_Proteoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804">
        <property type="entry name" value="AGGRECAN/VERSICAN PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804:SF24">
        <property type="entry name" value="NEUROCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019130683" description="Link domain-containing protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="11">
        <location>
            <begin position="167"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="11">
        <location>
            <begin position="268"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB71042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40382" checksum="17EC9A676593C38A" modified="2019-05-08" version="1" fragment="single">MAFCRLSMLHVPLHIAWLCLCLVPAASPHKTGDNDYEKIVNIKKVQHQPVIRGLADSVLLPCVFSVLPNSAIDPSLLPDPPRIKWTKVLLEGGSRKEIPVLVAKNNTVKLNPAYQGRVSLPGYGPFHYNASLEIVALRASDAGIYQCEVVVGIDDEQDTVPLEVLGVVFHYRAGSNRYSLTFEAATQACQDNSATIANPQQLLAAFQDGFDHCDAGWVSDQTVRYPIRSPRPGCYGDKFEYPGIRTYGIRDPGEQYDVYCYIKELKGTVFHETATRKLNLTEAIYHCQMQGAELATAGQLYMAWSQGFDQCDAGWLADGSVRYPINIPRKNCGGDVPGVRTVYQLPNRTGSPDPGSKYDVYCYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE13</accession>
    <name>A0A401PE13_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0005914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001918">
        <property type="protein sequence ID" value="GCB71358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE13"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB71358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="86" mass="9800" checksum="BC73089E35A6C4FC" modified="2019-05-08" version="1">MEMSRTVWNMAKRIAQQIAESSLPNHFSFINEEAEAVCTKLNDLRETEQSTVAGVLECKIWHEAKSWIFTNGKISGNFPLRTFLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEC7</accession>
    <name>A0A401PEC7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003475">
        <property type="protein sequence ID" value="GCB71476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEC7"/>
    <dbReference type="STRING" id="75743.A0A401PEC7"/>
    <dbReference type="OrthoDB" id="9949919at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB71476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="100" mass="12099" checksum="FF60DD4AF517BF19" modified="2019-05-08" version="1" fragment="single">VVSSRERAHEPCMKLKSKRLKSRFSLQKLSGLLMVTSAGQPRFLHFLCGFFKRTRYYRSMPKYHAVKIRKEERYFITEGFTKKKSQKKQWVTNWKDKDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFX3</accession>
    <name>A0A401PFX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0001780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntrophin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000414">
        <property type="protein sequence ID" value="GCB71999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFX3"/>
    <dbReference type="STRING" id="75743.A0A401PFX3"/>
    <dbReference type="OMA" id="NCKHEEV"/>
    <dbReference type="OrthoDB" id="9975356at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016013">
        <property type="term" value="C:syntrophin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06801">
        <property type="entry name" value="PDZ_syntrophin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000080">
        <property type="entry name" value="Syntrophin gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF2">
        <property type="entry name" value="GAMMA-1-SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB71999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="173" mass="19027" checksum="0E2CFE39CDE582F6" modified="2019-05-08" version="1">MGCCGRGICLLQDGTQEPFEVRLHLAKDILTIQEQDVICVSSEAFYSSERTVTIRRQTIGGFGLSIKGGAEHNIPVIISKISKEQRADLSGLLFIGDAILQINGINVRNCKHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLCEDCTCIPRFIIVFFMAHIIGPKVGKAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGP1</accession>
    <name>A0A401PGP1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002060">
        <property type="protein sequence ID" value="GCB72254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGP1"/>
    <dbReference type="OrthoDB" id="272687at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038888">
        <property type="entry name" value="CFAP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21532:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21532">
        <property type="entry name" value="PHOSPHODIESTERASE HL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="20721" checksum="A5342C8353BE605C" modified="2019-05-08" version="1">MIKLKCLLLFQRAMESKNASEQVTEDVASSEIGNKMGSGQQSSLSGQSNGTTRKVLGPLRVPVRGEEKPLPSEMGEKTAHQSDAAETWLQQAKKEAGISGSVLELSESERRQLHDRAAYLKEQRDKLVAMKKEQREKHLTKNPENQKPQPPLETKENLSEEEKQKIQKRRHLAEKLKQEVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIP7</accession>
    <name>A0A401PIP7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0002300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000566">
        <property type="protein sequence ID" value="GCB73010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIP7"/>
    <dbReference type="STRING" id="75743.A0A401PIP7"/>
    <dbReference type="OMA" id="MNAPSRY"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB73010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="13282" checksum="62701F49A96329D9" modified="2019-05-08" version="1">MNAPPAFESFLLFEGEKKITITKDTKVPNACLFTINKEDHTLGNTIRSQLLKDPQVLFAGYKVPHPLEHKIVIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIY3</accession>
    <name>A0A401PIY3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002264">
        <property type="protein sequence ID" value="GCB73090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIY3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB73090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8145" checksum="9FD16DFD407E0832" modified="2019-05-08" version="1">MLAGYSGRSYSAQPVANYLKDLLPDLCKNLRHIPAVGIKNREKKRQLVVAAIQAGKHGIDVNLNAVQTSEMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKD7</accession>
    <name>A0A401PKD7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000671">
        <property type="protein sequence ID" value="GCB73548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PKD7"/>
    <dbReference type="OMA" id="MRHELRH"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056741">
        <property type="entry name" value="BLTP1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25039">
        <property type="entry name" value="BLTP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="2">
        <location>
            <begin position="3453"/>
            <end position="3780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1657"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1974"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2663"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2782"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2900"/>
            <end position="2919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2960"/>
            <end position="2980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3185"/>
            <end position="3207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3409"/>
            <end position="3461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1657"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2816"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2960"/>
            <end position="2976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3424"/>
            <end position="3438"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3446"/>
            <end position="3461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="3780" mass="415780" checksum="3DADF29F5DBB0BC6" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PM53</accession>
    <name>A0A401PM53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ferric-chelate reductase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0003272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FRRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000881">
        <property type="protein sequence ID" value="GCB74185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PM53"/>
    <dbReference type="STRING" id="75743.A0A401PM53"/>
    <dbReference type="OMA" id="FPMADMT"/>
    <dbReference type="OrthoDB" id="2419613at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DOMON_SDR_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
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        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
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        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
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        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF44">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="14">
        <location>
            <begin position="58"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="12">
        <location>
            <begin position="267"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="390"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB74185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="68753" checksum="E5F27C5892CF3561" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMZ1</accession>
    <name>A0A401PMZ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Zinc finger and BTB domain-containing protein 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0003565</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000983">
        <property type="protein sequence ID" value="GCB74475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PMZ1"/>
    <dbReference type="OMA" id="GSCFDNT"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18223">
        <property type="entry name" value="BTB_POZ_ZBTB38_CIBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000235">
        <property type="entry name" value="Zinc finger and BTB domain containing 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000437">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000538">
        <property type="entry name" value="zinc finger protein 853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF58">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB74475.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1394" mass="155791" checksum="B28EA4D7C4E05336" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNK7</accession>
    <name>A0A401PNK7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001069">
        <property type="protein sequence ID" value="GCB74716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="124" mass="13833" checksum="18BE11DA2D50E379" modified="2019-05-08" version="1">MQQELETQKAALQQELGTEQAALQQELEILKAALQQELETQKAALHQELETEKAALQQVQEAEKAALQQDLETQKAALQLGLETEQAALQQELEILKAALQQELEILKAALQQELEILKAALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNX6</accession>
    <name>A0A401PNX6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB74833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        </location>
    </feature>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="12404" checksum="6F3D19C87938B955" modified="2019-05-08" version="1">MSWFRQNEKDEEWEKRPWEWMVRVEGGEEKVQGFTGEYYAVVNQAQDLSGGTKFRMKGKQEKKGEERVSGEKETGKERQISARKEENREKEEQMNGRKKKEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP78</accession>
    <name>A0A401PP78_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pancreatic progenitor cell differentiation and proliferation factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPDPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014892">
        <property type="protein sequence ID" value="GCB74908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP78"/>
    <dbReference type="OMA" id="NCEATHH"/>
    <dbReference type="OrthoDB" id="8543092at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026754">
        <property type="entry name" value="PPDPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14572">
        <property type="entry name" value="PANCREATIC PROGENITOR CELL DIFFERENTIATION AND PROLIFERATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15060">
        <property type="entry name" value="PPDFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9106" checksum="F7D1F4030A433678" modified="2019-05-08" version="1">MASVPSAGCLLAARNQYYRTRHNSTSSAASNSSCCLEMTMEHEKSHQGILLTLQKCSWLKNFLNCEATHHPVNTELSAGSGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSC7</accession>
    <name>A0A401PSC7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="4">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0019835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01015186">
        <property type="protein sequence ID" value="GCB76031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSC7"/>
    <dbReference type="STRING" id="75743.A0A401PSC7"/>
    <dbReference type="OMA" id="MEPKTIV"/>
    <dbReference type="OrthoDB" id="69989at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06775">
        <property type="entry name" value="cpPDZ_MBTPS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019403561" description="Membrane-bound transcription factor site-2 protease" evidence="12">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="13">
        <location>
            <begin position="55"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB76031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="251" mass="27794" checksum="E6FEA3E5C2B7CE6C" modified="2019-05-08" version="1" fragment="single">MAFGVVSMFVSMLLLAKTFSQTLALMTAEGPTPENERILQVVVPGVNLPISQMVYFFSAILISGVIHEVGHGVAAVREQVRFNGFGVFIFVIYPGAFVDLYTNHLQLISPIQQLRVFCAGVWHNFILALMALLGLYSLPIFLFPLYYTGSGALVTELTENSPASGPRGLSVGDFVKYVENCSVDSVENWHKCIEDISVKPQIGYCIKEEILQHLNSVGRVYRRLDGTTECCSNNSLVDICFSYRGKLQIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSQ0</accession>
    <name>A0A401PSQ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0019850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01015220">
        <property type="protein sequence ID" value="GCB76176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSQ0"/>
    <dbReference type="OrthoDB" id="2154780at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052297">
        <property type="entry name" value="RING-CH-type_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471">
        <property type="entry name" value="MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB76176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="16242" checksum="F208A5B70EBD57FF" modified="2019-05-08" version="1" fragment="single">MQGDSLCKTMESGYCKDTPFTDSAYMREVQRRRDNDYMSRLRLKELERMQAEQKREQRAAQPLARPIGYASRNYERPWLNGMPSNIKMDIVDTESRELQHSPTYPRTLISGRGSRLPSLHNIVGKKQKVPEQADVPEIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSU4</accession>
    <name>A0A401PSU4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011332">
        <property type="protein sequence ID" value="GCB76209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSU4"/>
    <dbReference type="STRING" id="75743.A0A401PSU4"/>
    <dbReference type="OMA" id="EIWHPNG"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8674" checksum="27FAD64D935C1B62" modified="2019-05-08" version="1">MYLELNKNPVDGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVAGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT62</accession>
    <name>A0A401PT62_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016542">
        <property type="protein sequence ID" value="GCB76297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT62"/>
    <dbReference type="STRING" id="75743.A0A401PT62"/>
    <dbReference type="OMA" id="PALKXEH"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000389">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF89">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="37613" checksum="528BC5F2D960E22E" modified="2019-05-08" version="1" fragment="single">MEILLLELFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFVKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARILPIMFPALYKNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKEKFKLKEREEIWQKIEDLAQHNPQSNAYIECLAISPVFSMETETPTTEDIQLLKKAVETEAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTD1</accession>
    <name>A0A401PTD1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0020468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016571">
        <property type="protein sequence ID" value="GCB76406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTD1"/>
    <dbReference type="STRING" id="75743.A0A401PTD1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB76406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="53" mass="5824" checksum="49C1BE2226B0F594" modified="2019-05-08" version="1" fragment="single">MNVTIDKESLNDSFVTLCGIWVLFMKVGLTCYEVGRSPAPSTVAILFKNVVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUV0</accession>
    <name>A0A401PUV0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0016624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010165">
        <property type="protein sequence ID" value="GCB76909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUV0"/>
    <dbReference type="STRING" id="75743.A0A401PUV0"/>
    <dbReference type="OMA" id="IPYAWDS"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02049">
        <property type="entry name" value="PROTEINF36A"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB76909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13354" checksum="75496C7AADDBDE2E" modified="2019-05-08" version="1">MSTETEAEKPKSFKLLGILDVQNTPCARDSVLYGSAGAVVAGLGHFLATSRVKRSFDFSVGSFLLATLGTWMFCRYQNAKLRIQQRIVQEGVKNKVTFEGTKMDPTRKSDRSSKDSQGKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUW0</accession>
    <name>A0A401PUW0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0019942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015386">
        <property type="protein sequence ID" value="GCB76911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUW0"/>
    <dbReference type="OrthoDB" id="8190486at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051299">
        <property type="term" value="P:centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902410">
        <property type="term" value="P:mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038923">
        <property type="entry name" value="Centrobin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439:SF1">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60467" checksum="25914068F3230DE7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUX6</accession>
    <name>A0A401PUX6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0017518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011472">
        <property type="protein sequence ID" value="GCB76917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUX6"/>
    <dbReference type="STRING" id="75743.A0A401PUX6"/>
    <dbReference type="OMA" id="TIAHEVI"/>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB76917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="26536" checksum="7A33E0BC26286328" modified="2019-05-08" version="1" fragment="single">MAGCYVVPVRQATNQIVMNCADIDIITASYVPEGAEEINATGFNYQNEDEKVTLSFPSALQKGHGMLKIDFVGELNDKMKGFYRSKYITPSGETHYAAVSQFEPTDARRAFPCWDEPAIKATFDITLIVSKDRIALSNMNVTERNPYPDDEDMVEVKFAKSPIMSTYLVAFVVGEYDFVETKSSDGILVRVYTPIGKADQGKFALEVAAKTLPFYKEYFNVPYPLPKIDLIAIADFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV72</accession>
    <name>A0A401PV72_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="2">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0018418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01012806">
        <property type="protein sequence ID" value="GCB77044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV72"/>
    <dbReference type="STRING" id="75743.A0A401PV72"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="11">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="322"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB77044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="425" mass="46187" checksum="5637ED12D13DE115" modified="2019-05-08" version="1" fragment="single">KSIGLPDVHSGYGFAIGNMAAFDVNDPQAVVSPGGVGFDINCGVRLLRTNLDEGDVQPVKEQLAQAMFDHIPVGVGSKGVIPMGAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPSKVSAKAKKRGLPQLGTLGAGNHYAEIQVVEEIYNDYAARKMGIDHKGQVCVMVHSGSRGFGHQVATDALVAMEKAMKRDNIIVNDRQLACARINSQEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDMHVIYDVSHNIAKVEEHVVDGKQKTLLIHRKGSTRAFPPHHPLIPVDYQLTGQPVLIGGTMGTCSYVLTGTDQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADKGIAIRVASPKLVMEEAPESYKNVTDVVNTCHEAGISKKAIKLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWU1</accession>
    <name>A0A401PWU1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Vacuolar proton pump 21 kDa proteolipid subunit c''</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0020591</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with IFITM3. Interacts with TM4SF19; this interaction inhibits V1-V0 complex assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">Clathrin-coated vesicle membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016853">
        <property type="protein sequence ID" value="GCB77595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWU1"/>
    <dbReference type="STRING" id="75743.A0A401PWU1"/>
    <dbReference type="OMA" id="MVNVACG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="14">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="14">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB77595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="15153" checksum="D07541E027AF7253" modified="2019-05-08" version="1">MVSTKGAPHCGGIYITGSSILGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSGTTPQTIGARNYQAGFSMFGAGLTVGFSNLFCGICVGIVGSGAALADAQNASLFVKILIVEIFGSAIGLFGVIVAILQTSKVKMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXX7</accession>
    <name>A0A401PXX7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EFCAB10 C-terminal EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015637">
        <property type="protein sequence ID" value="GCB77958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXX7"/>
    <dbReference type="STRING" id="75743.A0A401PXX7"/>
    <dbReference type="OMA" id="MHISTGQ"/>
    <dbReference type="OrthoDB" id="10260455at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056587">
        <property type="entry name" value="EF_EFCAB10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24548">
        <property type="entry name" value="EF_EFCAB10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFCAB10 C-terminal EF-hand" evidence="1">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="13109" checksum="3A5E8A656DBD2750" modified="2019-05-08" version="1">MIKDFGEAKVYDGTCREASRPVQFLIDQLELLKVARQTKKDYPCLFDDSNLDTVYGILDATKQGHITLRQYREALKTLGVKDFVMDPLGSIDNKITQATFKQEAKAGLANACATFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY46</accession>
    <name>A0A401PY46_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0018549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013033">
        <property type="protein sequence ID" value="GCB78051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY46"/>
    <dbReference type="STRING" id="75743.A0A401PY46"/>
    <dbReference type="OMA" id="MPYKAAA"/>
    <dbReference type="OrthoDB" id="9978265at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18307">
        <property type="entry name" value="BTB_POZ_calicin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048070">
        <property type="entry name" value="Calicin_BTB_POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF30">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13964">
        <property type="entry name" value="Beta-prop_Calicin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="595" mass="67427" checksum="B76553A46C7458C2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYG9</accession>
    <name>A0A401PYG9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009115">
        <property type="protein sequence ID" value="GCB78158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYG9"/>
    <dbReference type="STRING" id="75743.A0A401PYG9"/>
    <dbReference type="OMA" id="AQPHSYP"/>
    <dbReference type="OrthoDB" id="9935471at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31774:SF1">
        <property type="entry name" value="PROTEIN SHISA-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31774">
        <property type="entry name" value="PROTEIN SHISA-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="158" mass="17679" checksum="63310D3163FE4C29" modified="2019-05-08" version="1">MAQPHSYPTLAQGSHSFEQQVSGKELNKYASLKLVADKANDDFFSKRQHFAELAAKGTLPLHPVQMSLDHEGLAHSSATYPKLTGQRNKMTKMHTHPLVFDADYKTWDTNDTAVRRQAYANKRPCTVGPLAEKASAQPQLYMAQQPYFVTNSKTEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYT3</accession>
    <name>A0A401PYT3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013082">
        <property type="protein sequence ID" value="GCB78291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYT3"/>
    <dbReference type="OrthoDB" id="9360487at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="14308" checksum="7EF6D23B7CAB4510" modified="2019-05-08" version="1">MRRSAAPSQLSGNAAKKFRFIPPGKTDHREPVSGATRLQERNEAPHESDDNQSPLSQSKALLAKCERIQTCSSHQTTENVNEGGHLERSDHLTTIPTSSVGAPGTTRAGNYNFILLHSEMKFWISRILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZE8</accession>
    <name>A0A401PZE8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011800">
        <property type="protein sequence ID" value="GCB78529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZE8"/>
    <dbReference type="STRING" id="75743.A0A401PZE8"/>
    <dbReference type="OMA" id="IRWCLVA"/>
    <dbReference type="OrthoDB" id="9908599at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021097">
        <property type="entry name" value="CPH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055486">
        <property type="entry name" value="CUL7/CUL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22771:SF4">
        <property type="entry name" value="CULLIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22771">
        <property type="entry name" value="CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11515">
        <property type="entry name" value="Cul7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23168">
        <property type="entry name" value="CUL7_CUL9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUL7/CUL9 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CPH" evidence="2">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="468" mass="52549" checksum="84067E8DCEB0AED7" modified="2019-05-08" version="1" fragment="single">HTAVSRFPLRGTNRMGERRSKNLLVQLGPKMQAYPEELIRLRRSHDGLTEYLIRWNVLTVDDSGGGGSSSNGGNSSSSDNKVDNILMWMSAEDVYANCPTLLGKRKPEGQRVKEEQEPSSRCCPESADSDVTFDDVELLDMKDDVKHLVQRARRQMSRKSGPDSSLNISHTIHVLSAYASIGSLVGVFKETGALDVLMELLCNKETQTRRSAGKMLRALASHDAGSRAYVLLSLSQQDGIEQHMDFDNRYTLLELFAETTSSEEHGISFEGIHLPQIPGKLLFSLVKRYLCVTSLMDKLNNSGQDISGERQDCTALNIPEQTRLLREFEFTMAMANLISELVRVMGWERSKEPDRMMGVTEDLPRNIKSIFQPRSMATSNLLIPQPRKKTATTYKTRSNFASRSSYVEYIQENLKAGMTVKMLEDYEQVSCGDEGEFRYSNDGTPPVQIYVYESTGPKAPAQSFELCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q046</accession>
    <name>A0A401Q046_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxylysine kinase</fullName>
            <ecNumber evidence="8">2.7.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0020708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19049"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57882"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58357"/>
            <dbReference type="EC" id="2.7.1.81"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.81" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01017139">
        <property type="protein sequence ID" value="GCB78752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q046"/>
    <dbReference type="STRING" id="75743.A0A401Q046"/>
    <dbReference type="OMA" id="EFLTRIM"/>
    <dbReference type="OrthoDB" id="9973935at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047992">
        <property type="term" value="F:hydroxylysine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB78752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="292" mass="32461" checksum="726CA219E080ADAE" modified="2019-05-08" version="1">MPSYDDQNFHVLAPESQETGDLSKSYVLKVMNSVDSQDADLIEAQTRAMMFLNEKGFPSPIPIPTTDGKIMSLESIDYGKESKTHMVRLLTYLPGIPLAQMPTGPQILYKAGRTLAEMNRVLAVSQRILPVEVHFTRLNHGDFSHTNILVQPVQSSADHSDPTHPQQALDISGILDFTDMNYGCSVCDVAISIMYLMLESSDPLSTGGHVLSGFESVTPLVPEERDAVFLLVLCRFSQSLVLARYNILLYPGNAEYLLTTARSGWKCLHQLWSLGKEAVEKIWYEAAKPHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q200</accession>
    <name>A0A401Q200_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0018751</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013350">
        <property type="protein sequence ID" value="GCB79437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q200"/>
    <dbReference type="STRING" id="75743.A0A401Q200"/>
    <dbReference type="OMA" id="QCASANW"/>
    <dbReference type="OrthoDB" id="8197458at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000092">
        <property type="entry name" value="Early growth response protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021849">
        <property type="entry name" value="EGR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF54">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE EGR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11928">
        <property type="entry name" value="DUF3446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB79437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="416" mass="46129" checksum="F0C76285C57C26C0" modified="2019-05-08" version="1">MTAKTAEKIPLSLGGLFHQLPESMYSVDEISSLPVSLAAFTNQELAQYEQMPSADGMINVDMCSEKRPIDLPYHNYHPNPASRGQTFTYMGKFSIDSQCASANWSPDGIINIVSTGIFGVPPPSSTSSSSSSSSSASPNPLSSTLSCTMAQNPSEMEHMYSPPPPYTCGEIYQEPAPFFSTSTCSLGYPPPSYPSPKPVVDNTLYPILPEYSSIFQPQHPHRELNPGTERKPFSCPVEQMRMAPPLTPLSTIRNFTLGNPSGEGARLPSAYGGHNLPLRPIRLRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFSCDFCGRKFARSDERKRHTKIHLRQKEKKLASERAASSTVTTLCSGSSPLTVCPPRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2I6</accession>
    <name>A0A401Q2I6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016046">
        <property type="protein sequence ID" value="GCB79576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2I6"/>
    <dbReference type="STRING" id="75743.A0A401Q2I6"/>
    <dbReference type="OMA" id="QSITHYE"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04389">
        <property type="entry name" value="RhoGAP_KIAA1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000011">
        <property type="entry name" value="Rho GTPase-activating protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="215" mass="24749" checksum="242CC9F9AB3947D1" modified="2019-05-08" version="1" fragment="single">KPSTDEIRHATNAVFCPSMFGSSLDEIMNMQHEHYPDRQLPWVQTRLSEEVLKLNGAQTEGIFRVPGDIDEVNALKLQVDQWVIPEGLTDPHVPASLLKLWYRELEDPLIPHEFYEQSITHYENPEAAIAVVHSLPKLNRLVLGYLIRFLQIFVQPANVSVTKMDVNNLAMVMAPNCLRCQSDNPRIIFENTRKEMSFLRVLIQHLDTSFMDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4I3</accession>
    <name>A0A401Q4I3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012251">
        <property type="protein sequence ID" value="GCB80286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4I3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="53" mass="5956" checksum="F2F6E5E483FB5D0C" modified="2019-05-08" version="1" fragment="single">RPATNGKIGGPEGLWSSRFVRMKFELQIECAQHLILEEEELQTEISNVTPQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4J5</accession>
    <name>A0A401Q4J5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010877">
        <property type="protein sequence ID" value="GCB80288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4J5"/>
    <dbReference type="STRING" id="75743.A0A401Q4J5"/>
    <dbReference type="OMA" id="KKSCKSW"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="16653" checksum="CA194F0EE2493459" modified="2019-05-08" version="1">MLVNVAVCEISSLHNRCLVVVMGKSESQMDIVERNPPKSKKSCKSWTSLEIGLTTIVVLLLIVLIALIALYATRKDKTCTTPSCVGAAARIIENMDQAADPCNNFYQYACGGWLKKHVIPETSSRYSTFDILRDEMEVILKAVVGVRWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q511</accession>
    <name>A0A401Q511_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0016208</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009657">
        <property type="protein sequence ID" value="GCB80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q511"/>
    <dbReference type="STRING" id="75743.A0A401Q511"/>
    <dbReference type="OMA" id="CISIHAD"/>
    <dbReference type="OrthoDB" id="6073114at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000016">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="131"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="335" mass="37379" checksum="4E3DBAD8680CFC5B" modified="2019-05-08" version="1">MRECISIHADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQISTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVSEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGTESIEGEGEAEEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5E9</accession>
    <name>A0A401Q5E9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011022">
        <property type="protein sequence ID" value="GCB80582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5E9"/>
    <dbReference type="STRING" id="75743.A0A401Q5E9"/>
    <dbReference type="OMA" id="RYSCHAY"/>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000043">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF243">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="13306" checksum="31924070C5CBDAF5" modified="2019-05-08" version="1">MECQPPRGHPEPTISWKKDNALLDDKDERITIRGGKLMITNTRKSDAGKYVCVGTNMVGERDSEVGELTVLEQPYFVKKPNSQVVLVDATVEFKCEARGDPIPNVHWRNEEGILPKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5J8</accession>
    <name>A0A401Q5J8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0016280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009750">
        <property type="protein sequence ID" value="GCB80617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5J8"/>
    <dbReference type="STRING" id="75743.A0A401Q5J8"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009306">
        <property type="entry name" value="DUF963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021654">
        <property type="entry name" value="EZH1/EZH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041343">
        <property type="entry name" value="PRC2_HTH_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06131">
        <property type="entry name" value="DUF963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11616">
        <property type="entry name" value="EZH2_WD-Binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18118">
        <property type="entry name" value="PRC2_HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Polycomb repressive complex 2 subunit EZH1/EZH2 tri-helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="EZH1/2 MCSS" evidence="5">
        <location>
            <begin position="246"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="546" mass="62277" checksum="A6A65C1C89512208" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5V1</accession>
    <name>A0A401Q5V1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027402">
        <property type="protein sequence ID" value="GCB80741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5V1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9520" checksum="6ABCCFEE6B465769" modified="2019-05-08" version="1" fragment="single">ISSLYLTKRGKVTTGAFEQFFGNCQDPGYLIGHEESETQGAVNKLQEESQKIFLPEIRGYAESIHPQEQVQIVTRMDSNCRKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6U6</accession>
    <name>A0A401Q6U6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0022962</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Choline transporter.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Choline/H+ antiporter.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>choline(out) + n H(+)(in) = choline(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:75463"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025187">
        <property type="protein sequence ID" value="GCB81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6U6"/>
    <dbReference type="STRING" id="75743.A0A401Q6U6"/>
    <dbReference type="OMA" id="EQCTIAG"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF42">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="20421" checksum="9B7E73AB860FE1EE" modified="2019-05-08" version="1" fragment="single">RFLSTSGEAIYKVVTNRGHCIYANRTCDPEIFNTSNVTKLCPGAQCAFAFYGGESLYHKYIFILQICNLFVFLWLVNFAIALGQCTLAGAFASYYWAFRKPADIPSFPLLAAFGRSLRYHTGSLAFGSLILAIIQLIRIILEYLDNKLKGESPINSALMLVTEYTLAIRQGFRRNILANLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7P7</accession>
    <name>A0A401Q7P7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026691">
        <property type="protein sequence ID" value="GCB81386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7P7"/>
    <dbReference type="STRING" id="75743.A0A401Q7P7"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF1">
        <property type="entry name" value="F-BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB81386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="93" mass="11094" checksum="6AF5DF42ACA389D0" modified="2019-05-08" version="1" fragment="single">DDKVKHNVCWMELFRQFYCDLGQYIDHYAELKQAWENLKKYLGQKCPRMITSLNVGLTEQEMEAVEERIQFSLPKDYRCSLRIHNGQRLVVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAU5</accession>
    <name>A0A401QAU5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-2-microglobulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0022682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-2-microglobulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023494">
        <property type="protein sequence ID" value="GCB82514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAU5"/>
    <dbReference type="STRING" id="75743.A0A401QAU5"/>
    <dbReference type="OMA" id="WCVVLVW"/>
    <dbReference type="OrthoDB" id="9949628at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF62">
        <property type="entry name" value="BETA-2-MICROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0490">MHC I</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019569281" description="Beta-2-microglobulin" evidence="8">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB82514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12311" checksum="020B1749D2AFC803" modified="2019-05-08" version="1">MLKLAVLSLMVALCLATTAPDVQVYTYKPIKEGKSNVLLCHAKGFTPPNIKLELLMDGQILNHANQSDLSFVADWSFRLTRFAEITPQSGVKYACKVEHNGVIKTVQLDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAZ0</accession>
    <name>A0A401QAZ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA selenocysteine-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0022686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM TRSPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023526">
        <property type="protein sequence ID" value="GCB82549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAZ0"/>
    <dbReference type="STRING" id="75743.A0A401QAZ0"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000166">
        <property type="entry name" value="Trna selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040434">
        <property type="entry name" value="TSAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457:SF1">
        <property type="entry name" value="SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB82549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="9228" checksum="B1AB3B5B6ADBC287" modified="2019-05-08" version="1" fragment="single">QEYSIFVGDLSSEVDDFHLYDYFVKKYPSCRGGKVVTDTSGNSRGFGFVRFSDEAEQKKALEECQNSKGLGGKPIRISIAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBA3</accession>
    <name>A0A401QBA3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022349">
        <property type="protein sequence ID" value="GCB82659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBA3"/>
    <dbReference type="STRING" id="75743.A0A401QBA3"/>
    <dbReference type="OMA" id="GHCIEAP"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF22">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18835" checksum="A058B8AD0064B4C5" modified="2019-05-08" version="1" fragment="single">TQRLQDFVFEAEQTYFATRVLISSKYLQTVMPFHLVKYDVEQEAPVRDSNGHCIEAPQGETGLLIAKITAKSPFIGYVGNESLTAKKHLRDVFSKGDLYFNSGDLMMLDHENFIYFQDRIGDTYRWKGENVSTNEVADILSMLDFVQEACVYGVTVPGSSGRLSGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBJ4</accession>
    <name>A0A401QBJ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0023942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TGF-beta family. GDNF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01036187">
        <property type="protein sequence ID" value="GCB82765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBJ4"/>
    <dbReference type="STRING" id="75743.A0A401QBJ4"/>
    <dbReference type="OMA" id="SECSCIG"/>
    <dbReference type="OrthoDB" id="9936891at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030116">
        <property type="term" value="F:glial cell-derived neurotrophic factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19382">
        <property type="entry name" value="TGF_beta_Persephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043401">
        <property type="entry name" value="GDNF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173">
        <property type="entry name" value="GDNF SUBFAMILY OF TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173:SF8">
        <property type="entry name" value="PERSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB82765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="17572" checksum="4457B537E7BBC88A" modified="2019-05-08" version="1" fragment="single">KAALLPRVPNIRSEAEFTISPLPVLISSLEPQSNPPRARRKRKMSVSRKGEEWEERSCRLRALQLRVQDLGLGYQSDEIVLFKYCSGSCPQAQNNHNLILSLLLRKPGFPNLSQEKIVSNPCCRPTHFKDVTFLDLNNQWHTVEKLSASECSCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBR2</accession>
    <name>A0A401QBR2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01036364">
        <property type="protein sequence ID" value="GCB82819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBR2"/>
    <dbReference type="STRING" id="75743.A0A401QBR2"/>
    <dbReference type="OrthoDB" id="5981048at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="156" mass="17206" checksum="805D40CB824C93BD" modified="2019-05-08" version="1">MEISAGSPINGEVTNDSQINVEMTKDCPINVEITNDCPINVEITNDCPINSENTNDCPIDVEISHACSIYVEVSNDCPINVDVTNNVPSNVQISNDCHINVEISNNCPLNVENINDFPINVEIYNDCPITVEITNDCIINMEFSNDFIINVEISNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCG7</accession>
    <name>A0A401QCG7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ADAMTS cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0023632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01031545">
        <property type="protein sequence ID" value="GCB83046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCG7"/>
    <dbReference type="STRING" id="75743.A0A401QCG7"/>
    <dbReference type="OrthoDB" id="9942326at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF20">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="ADAMTS/ADAMTS-like cysteine-rich" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="ADAMTS/ADAMTS-like Spacer 1" evidence="3">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB83046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10964" checksum="AE9970FE86DBCEBD" modified="2019-05-08" version="1" fragment="single">MSRAESFVDGTRCEMSDSAATSSYRLCVMGRCRIFGCDGKLDSGQMMDNCRVCGGNNSSCRRLVSSFTEGTAREYVTFLTVPPQSTNVRISNNQAVFSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD08</accession>
    <name>A0A401QD08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01035894">
        <property type="protein sequence ID" value="GCB83269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD08"/>
    <dbReference type="STRING" id="75743.A0A401QD08"/>
    <dbReference type="OMA" id="KTHGICW"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="161" mass="17605" checksum="271945F5BAC975F7" modified="2019-05-08" version="1">MYSGVAARVYKQRQKQLGAGNHDQAFKYLGQDYEALRDDCLDRGVQFVDPHFPVGPSILGFKELGPGTSKTYGIRWKRPKVSVNRALSVNRALSVNMALSVNRTLSVNGALSMSWALSVNRALSVNRALSVNRTLSVNGALSMSWALSVNRALSMNGTQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDD7</accession>
    <name>A0A401QDD7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4E type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034823">
        <property type="protein sequence ID" value="GCB83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDD7"/>
    <dbReference type="STRING" id="75743.A0A401QDD7"/>
    <dbReference type="OMA" id="MHARFRK"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF76">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E CLASS II 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15151" checksum="3F563B04AAADC9D6" modified="2019-05-08" version="1" fragment="single">AVSPGAGEHPLQYNYTFWYSRRTPSRPANTQSYEQNIKQIGTVASVEQFWRFYSHLVRPGDLTGHSDFHLFKEGIKPMWEDEANKNGGKWIIRLRKGLASRFWENIILAMLGEQFMVGEEICGVVVSIRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDX7</accession>
    <name>A0A401QDX7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01040147">
        <property type="protein sequence ID" value="GCB83571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDX7"/>
    <dbReference type="STRING" id="75743.A0A401QDX7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8347" checksum="BBF762EA93C07949" modified="2019-05-08" version="1" fragment="single">LKAVHEQLAALSQAPVSKPKKKKEKKEKKKKEKHKVKVEEEKKGKSSQASKQAHSKKHGSKKSGSANSLSRCDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE38</accession>
    <name>A0A401QE38_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSKIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01041560">
        <property type="protein sequence ID" value="GCB83623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE38"/>
    <dbReference type="STRING" id="75743.A0A401QE38"/>
    <dbReference type="OMA" id="FCEVADW"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019207">
        <property type="term" value="F:kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037395">
        <property type="entry name" value="GSKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490:SF4">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="2">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="144" mass="16214" checksum="4B95458015327BE1" modified="2019-05-08" version="1" fragment="single">AARKLANLQSLQKDQYHIQTMDCEPQDLKQSMVNNFCEVADWEERDFEGADVKDMRVEAEAVVNDVNFAVRHMAVSKSLPVGEDVAYINVETKEGNKYCLELTEAGLRVRAALTDTNSQKMTGLVKDVFFIFTLLSPLNDSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFR7</accession>
    <name>A0A401QFR7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0024644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01052271">
        <property type="protein sequence ID" value="GCB84192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFR7"/>
    <dbReference type="STRING" id="75743.A0A401QFR7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB84192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15549" checksum="5AE40824E3230CB3" modified="2019-05-08" version="1" fragment="single">MVVGTMGPSKESAGQEETGWGSFSRGNNQGAQRVLRKIIWLKSKEGIRKDESREDCQPPPTVMSSSGRGGGGTTLAAETAPPAGSVLLSAPPRSRIYKIIVIGDSGVGKTCLTYRFCAGSFPDKTEATIGVDFRERTVEIDGEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG14</accession>
    <name>A0A401QG14_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01067772">
        <property type="protein sequence ID" value="GCB84247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG14"/>
    <dbReference type="STRING" id="75743.A0A401QG14"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001956">
        <property type="term" value="P:positive regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905413">
        <property type="term" value="P:regulation of dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF1">
        <property type="entry name" value="BAI1-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="50" mass="5822" checksum="F58726E64C9943F2" modified="2019-05-08" version="1" fragment="single">MVPDLRKYIQHISLSPDSIQPDDAVSPLMKFLDDNLIILSEWLVRKNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGZ6</accession>
    <name>A0A401QGZ6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01084115">
        <property type="protein sequence ID" value="GCB84640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGZ6"/>
    <dbReference type="STRING" id="75743.A0A401QGZ6"/>
    <dbReference type="OMA" id="PHEHTIQ"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="9006" checksum="6327A300C5FE75EA" modified="2019-05-08" version="1" fragment="single">MYQCYSEGTYLEEELMKAREKPKLRKDMYKKMVEVDLQAPTSEEHTLQAVLKPRYMQWRETLSSSATLGFRIEGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH74</accession>
    <name>A0A401QH74_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01092604">
        <property type="protein sequence ID" value="GCB84739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH74"/>
    <dbReference type="STRING" id="75743.A0A401QH74"/>
    <dbReference type="OMA" id="RAMFRGP"/>
    <dbReference type="OrthoDB" id="9863247at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIDLINE-1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="178" mass="20234" checksum="84FD15EFE36F88E6" modified="2019-05-08" version="1" fragment="single">LNFKLDEKTAHSCLDLFKKETGVIYRVIGIDPSKVPKNPERFREWAVVFADVTLSTGRHYWEVTVKRSYEFRIGVAEANMSREECIGANDCSWVYAHLQRKWYSMASNEMVPVDFFGKPDRVGFLLDCEGRKLSLIDVEKAAVVSTITAEFKMPLVPAFALWNGELLTHSGLDILQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIL6</accession>
    <name>A0A401QIL6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein regulatory complex protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0025841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01132031">
        <property type="protein sequence ID" value="GCB85216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIL6"/>
    <dbReference type="STRING" id="75743.A0A401QIL6"/>
    <dbReference type="OMA" id="GHAGNCA"/>
    <dbReference type="OrthoDB" id="7760980at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029440">
        <property type="entry name" value="DRC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14775">
        <property type="entry name" value="NYD-SP28_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1 C-terminal" evidence="5">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB85216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="152" mass="17758" checksum="1FFE7E354168F83F" modified="2019-05-08" version="1" fragment="single">GEHILKMAEMCRRLETEEEKVLPFYASSLTPEEENKVQYLMIMQPCEELAEVMMDYVALEQFWKRYNKVLLDQVVLQQEKRTLLQENRHLRQLLKQYLDGISVNEEILSNLNPLIVINNKTNVKMSMPVIESAASKPVYNVIEAAHIINHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIV4</accession>
    <name>A0A401QIV4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01148333">
        <property type="protein sequence ID" value="GCB85302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIV4"/>
    <dbReference type="STRING" id="75743.A0A401QIV4"/>
    <dbReference type="OMA" id="DADAFFI"/>
    <dbReference type="OrthoDB" id="10629680at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="128" mass="14714" checksum="B15BE24052462E3D" modified="2019-05-08" version="1" fragment="single">LHIDPNQLHIDPDLLHTDPDLLHTDPNQLPTDPDLRHIDPNQLHIDPNLLHADPDLLHIDPNLLHTDPNQLHTDPNKLHIDPILLHIDPNLLHTDPNQLPTDPDLRHIDPNQLHIDPNQLHIDPILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKG8</accession>
    <name>A0A401QKG8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01212085">
        <property type="protein sequence ID" value="GCB85911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKG8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="48" mass="5831" checksum="0CF3D57EE0FCCF3B" modified="2019-05-08" version="1" fragment="single">AAVISQQLMQQHEAHLEELMDVKESAEEYEEMIELQIEWERLRRLTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLP6</accession>
    <name>A0A401QLP6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01262262">
        <property type="protein sequence ID" value="GCB86309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLP6"/>
    <dbReference type="STRING" id="75743.A0A401QLP6"/>
    <dbReference type="OMA" id="QYIPDQY"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="19659" checksum="60C9D864A1007563" modified="2019-05-08" version="1" fragment="single">PDSYYSDSYYPDRFYPDSNCLDNDYPDSYCPDSYYADSYYPDSYYPDSYYSDSYYPDRFYLDSYYPDSYYPDSFYPDSYIPDSYCPDNDYRDSNYPDSYYSDSYYTDRFYPDSYYPDSYSPDNDYPDSYYPDSYYPDSYYPDSYYPESDYPDSCYPDSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGI2</accession>
    <name>A0A401NGI2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA (cytosine-5)-methyltransferase</fullName>
            <ecNumber evidence="15">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0012625</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01006156">
        <property type="protein sequence ID" value="GCB59896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NGI2"/>
    <dbReference type="OMA" id="CKEMAPL"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04760">
        <property type="entry name" value="BAH_Dnmt1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04711">
        <property type="entry name" value="BAH_Dnmt1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2230:FF:000001">
        <property type="entry name" value="DNA (cytosine-5)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000004">
        <property type="entry name" value="DNA (cytosine-5)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000036">
        <property type="entry name" value="DNA (cytosine-5)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.120.10:FF:000001">
        <property type="entry name" value="DNA (cytosine-5)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022702">
        <property type="entry name" value="Cytosine_MeTrfase1_RFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12047">
        <property type="entry name" value="DNMT1-RFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037404">
        <property type="entry name" value="DNMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 15 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="22">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="21">
        <location>
            <begin position="546"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="20">
        <location>
            <begin position="657"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="20">
        <location>
            <begin position="877"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="190"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1001"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1015"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 18">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB59896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1494" mass="168434" checksum="CB5DF4F72A532AF6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGS5</accession>
    <name>A0A401NGS5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006177">
        <property type="protein sequence ID" value="GCB59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGS5"/>
    <dbReference type="STRING" id="75743.A0A401NGS5"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000196">
        <property type="entry name" value="Glutamate metabotropic receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019015131" description="Receptor ligand binding region domain-containing protein" evidence="7">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="8">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB59986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="219" mass="23502" checksum="53C06FED2BFC6416" modified="2019-05-08" version="1">MRIASLRHCLLLLVAAQCYWLLAVPQSSAAQEHAHSIRLEGDIILGGLFPVHSRGQSGAPCGEIKKEKGIHRMEAMLHAVDQLNRDPELLANITLGVRILDTCSRDTYALEQSLTFVQALIEKDTTDVRCASGEPPIISKPDKIVGVIGASASSVSIMVANILRLFKQMLRNGTVGAALGNSDCVSIGVNIQHVCAVHIGPHSALASWSQPDIGDNVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGS6</accession>
    <name>A0A401NGS6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0012682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HINT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006197">
        <property type="protein sequence ID" value="GCB60119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGS6"/>
    <dbReference type="STRING" id="75743.A0A401NGS6"/>
    <dbReference type="OMA" id="LAFMDVM"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="6">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 5">
        <location>
            <begin position="110"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="13725" checksum="D54AA08C0EFC5824" modified="2019-05-08" version="1">MAAETAKARNAQAGGDTIFGKIIRKEIPCDLLYEDDKCIAFHDIQPQAPTHFLVVPKKPIAQLSKAEDSDAELLGHLLIVAKKCALKLGLTNGYRLVLNEGQDGGQSVYHVHLHVCGGRQMLWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH80</accession>
    <name>A0A401NH80_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002375">
        <property type="protein sequence ID" value="GCB60223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH80"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="12944" checksum="8A878223B977D06D" modified="2019-05-08" version="1">MGRTWLERIKLNWAAMNFMLEFEAGPTKSLMEQKVTAAEKSLKAAEAKAQARSAGTKMTSAQYSVTNVVHDRETKDEEITEVAYECFDKNEGQNYAEKFSENDRNAFMCSLCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHR5</accession>
    <name>A0A401NHR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004957">
        <property type="protein sequence ID" value="GCB60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHR5"/>
    <dbReference type="STRING" id="75743.A0A401NHR5"/>
    <dbReference type="OMA" id="MMISTYL"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000008">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="11272" checksum="948B2AE57ACF7D36" modified="2019-05-08" version="1">MADPRTRQIKIRTGVVKRLAKEKLMYEKEAKQQEEKVEKMKVDGNDQYVVKKQIEVLQESRMMIPDCQRRLATAHSDLAQLLPTRSPGTFQDMDPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIM1</accession>
    <name>A0A401NIM1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004999">
        <property type="protein sequence ID" value="GCB60720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIM1"/>
    <dbReference type="STRING" id="75743.A0A401NIM1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="19128" checksum="C472B2B36AD570D7" modified="2019-05-08" version="1">MANSRTGLVRLELGRSCLLQTFLPISEADKEPHFAAEESHCFFVNAAEESHCFFVDAAEESHCFFADAAEESHCFFVDVAEESHCFFVDDCVESHCCFVDAVEESHCFFVDAVEDSHCLFVDGCEESHCFFVDVVEESHCFVFDDYEESHCLFVDAVEESHCFFEDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIP6</accession>
    <name>A0A401NIP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0014224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01007558">
        <property type="protein sequence ID" value="GCB60761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIP6"/>
    <dbReference type="STRING" id="75743.A0A401NIP6"/>
    <dbReference type="OMA" id="DIEIQHA"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="293"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="518"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB60761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="706" mass="79238" checksum="506492F3F126358F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIV5</accession>
    <name>A0A401NIV5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003715">
        <property type="protein sequence ID" value="GCB60799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIV5"/>
    <dbReference type="STRING" id="75743.A0A401NIV5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="46" mass="5072" checksum="2E802ABA6109E464" modified="2019-05-08" version="1" fragment="single">MSGSILRASIRAVSARRRLIPTRAALTLTPLAVNKIKQLLQEKPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK17</accession>
    <name>A0A401NK17_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005064">
        <property type="protein sequence ID" value="GCB61205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK17"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="9598" checksum="A8FE0D9FEAB2753A" modified="2019-05-08" version="1">MKAREGSGKDTVKECEERGGYRVKESEVSGGDTVKECEESGGDTVKEREESGRDTVKECGESGGVSVNEREESCGDTLKEREESSGDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKJ7</accession>
    <name>A0A401NKJ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0011306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005086">
        <property type="protein sequence ID" value="GCB61390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKJ7"/>
    <dbReference type="STRING" id="75743.A0A401NKJ7"/>
    <dbReference type="OMA" id="RRICKEQ"/>
    <dbReference type="OrthoDB" id="6755574at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000005">
        <property type="entry name" value="Serine protease 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012224">
        <property type="entry name" value="Pept_S1A_FX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF52">
        <property type="entry name" value="GRANZYME K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001143">
        <property type="entry name" value="Factor_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="123"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001143-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB61390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="380" mass="42515" checksum="26A3DE2B2B1B2FAC" modified="2019-05-08" version="1">MIIYFLTPGDDCVEIIGGQNVRPHSKPYMASIQLHKRHVCGGVLIKPGWVLTAAHCNREFKQQNITVVVGTDSLSRGKDKSAQRLAVKHKIPHLRFDSKTFENDIMLLQGDSGGPLIYHGAEIIGGREVKPHSKPYMVSIQGYSNGKNSYNHFCGGALIRTRWVLTAAHCYNSTSNRSLRVVLGAHSLSRNEKSQQKLPVKEQHPHPGFNKRTPENDIMLLELFNEAKINKYVKLLKLPKDKGADVKPRTSCEVAGWGLTTINSRHPSDTLQEVKLNVIDRKTCNSKDYYNHKPDVTMNMICAGDSKGRKDTCSGDSGGPLICRNKYKGIVSYGRGCAVPKKPGIYTLISKKYLNWIEKIIGVQTYNMTAVENVESLFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKN6</accession>
    <name>A0A401NKN6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0009334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003787">
        <property type="protein sequence ID" value="GCB61425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKN6"/>
    <dbReference type="STRING" id="75743.A0A401NKN6"/>
    <dbReference type="OMA" id="LLCEMRF"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="91"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB61425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="259" mass="28868" checksum="E2CD014617CAB9DE" modified="2019-05-08" version="1">MLRGLSSCAGPTAAWRLVAGIPLARRPWAGIPLIQPPPAGFPPGGSVRWAGLRGLCTGAGGCWRCGAAPLEAPGFFCSSCRALQPADRRRDYFQLLGLPRRFRLSAERLSRSQRRLQRVLHPDNFSRSAEAERRFSEEQSALVNEAYGTLLRPLSRGLYLLRLELPAEAQPEEAGGELPAGDPAFLAVVLRLNEQLEEARGPEDIGRVAEEVEARLRELTELVAQAFEQGRPRETRPLLRQMRFWSSLSERVKERLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLH3</accession>
    <name>A0A401NLH3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0007099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002511">
        <property type="protein sequence ID" value="GCB61735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLH3"/>
    <dbReference type="STRING" id="75743.A0A401NLH3"/>
    <dbReference type="OrthoDB" id="9991972at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF31">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="162"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB61735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="739" mass="84050" checksum="608387B07DF81C7A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLZ6</accession>
    <name>A0A401NLZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0009416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Probably a dodecamer composed of six biotin-containing alpha subunits (MCCC1) and six beta (MCCC2) subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01003842">
        <property type="protein sequence ID" value="GCB61880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLZ6"/>
    <dbReference type="STRING" id="75743.A0A401NLZ6"/>
    <dbReference type="OMA" id="GATTHCE"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="11">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="12">
        <location>
            <begin position="285"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB61880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="539" mass="58597" checksum="0E9B8D52C4173119" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM51</accession>
    <name>A0A401NM51_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005162">
        <property type="protein sequence ID" value="GCB61953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM51"/>
    <dbReference type="STRING" id="75743.A0A401NM51"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="61"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="21967" checksum="30324D6BE378DE9B" modified="2019-05-08" version="1">MAIGYTLITPSSQIIINQDRKDETFVFFALRSELQEKMALRSSVILLAICLLYQLRTSNGFSWDDCSATHEPVTFREISIGQDPVQLPGTLQYKVSMHLSTSLSSMTAEVTLYRKFLFWWKLPCFDPSICQIDVCELSTSACPFNSGIISSSGEMELPRPPISRTWLRGYYSATVILKSYGSKVGCVNIYFNIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM94</accession>
    <name>A0A401NM94_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Shisa N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005169">
        <property type="protein sequence ID" value="GCB62011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM94"/>
    <dbReference type="STRING" id="75743.A0A401NM94"/>
    <dbReference type="OMA" id="NTSHRYC"/>
    <dbReference type="OrthoDB" id="9836398at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053891">
        <property type="entry name" value="Shisa_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31774:SF0">
        <property type="entry name" value="PROTEIN SHISA-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31774">
        <property type="entry name" value="PROTEIN SHISA-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13908">
        <property type="entry name" value="Shisa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019150653" description="Shisa N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Shisa N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="187" mass="21181" checksum="2EC4E45247FFEC35" modified="2019-05-08" version="1">MQHLLLFLVYMDPLSLLVCAGRSRNNRTLPSPRRQGANTSRAAPANTTVVVPVLQINRMKPLVLQHSEKCRGHYDVAGQWDPDFECNRTSYNYCCGTCYMRYCCQDKNYRLEQNGCKNYVTPKVEIQVTTDPDLGKLENVYDPSKDKTNSTVYITCGVIAFVIIAGVFGKVAYDKATRPPREMNVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMH7</accession>
    <name>A0A401NMH7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-D1-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0000001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000001">
        <property type="protein sequence ID" value="GCB62105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMH7"/>
    <dbReference type="STRING" id="75743.A0A401NMH7"/>
    <dbReference type="OMA" id="GASHICP"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000005">
        <property type="entry name" value="cyclin-D1-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.10:FF:000008">
        <property type="entry name" value="Cyclin-D1-binding protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="9">
        <location>
            <begin position="191"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB62105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36952" checksum="07E38FDEE5B1C017" modified="2019-05-08" version="1">MNPRALLTCQPGLLWKWGAEGESLWKSEDFDLHYFWKTLGECFKAISQEATKLSLAFSKPPLPSVQDCQKLTADFQKNILNLTTVYYWLPKSQGVTLRRLVRDATMDIVEGVIQLLNVILSTPLQSLSQDQLASTGAVWEACDRFSKLPKDNKAAVQSLMSSYAAIVEDALEEIEQARHADNPDPFSDIFDDGDSRENRDTYWSEADKQVMAPCLGLVKAAKACLKKVSVAMTTHGKVDSLQHITQLDDLGDITSEISPNVDELILSLYPPMDYMTVQINASKVAFVLNKVLEITKSSHMCPESENTWLQFLSGAIEHNMDKVKDLTQGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMQ3</accession>
    <name>A0A401NMQ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0004206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001230">
        <property type="protein sequence ID" value="GCB62156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMQ3"/>
    <dbReference type="STRING" id="75743.A0A401NMQ3"/>
    <dbReference type="OMA" id="RILACGR"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF28">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB62156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="286" mass="32101" checksum="A49DC7FADF097E70" modified="2019-05-08" version="1">MALNATCRPAAPLARDSSGPLPEVVELNVGGQVYFTRLSTLTSLPNSVLGRMFGHKRNSGSPDLARDNRGRFFIDRDGFLFRYILDYLRDRAVVLPELFPEKLRLRREAEFFQLPDLVRMLSPEDGQSPGLEEPSHSDLDELSQGSDLPRAGSQAAERRAGFITLGYRGSCVLGRDSMQGDARLFRRVPRILACGRIGLLKEVFGDNVNESRDPDRTPDRYTSRFYLRYRQLERAFDTLAEAGFTLLGSNSSLTGSVCGQAIDDRAWSSYTEYLFYRLPTTLCAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN35</accession>
    <name>A0A401NN35_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0014471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007776">
        <property type="protein sequence ID" value="GCB62269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN35"/>
    <dbReference type="OMA" id="MELITIT"/>
    <dbReference type="OrthoDB" id="8951018at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019485974" description="CUB domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="35"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB62269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="679" mass="74207" checksum="38A28AB106CC8686" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNV2</accession>
    <name>A0A401NNV2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001254">
        <property type="protein sequence ID" value="GCB62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNV2"/>
    <dbReference type="STRING" id="75743.A0A401NNV2"/>
    <dbReference type="OMA" id="HLNCNAD"/>
    <dbReference type="OrthoDB" id="6358435at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023240">
        <property type="entry name" value="BRISC_Abraxas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023238">
        <property type="entry name" value="FAM175"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31728">
        <property type="entry name" value="ABRAXAS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31728:SF1">
        <property type="entry name" value="BRISC COMPLEX SUBUNIT ABRAXAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21125">
        <property type="entry name" value="MPN_2A_DUB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02053">
        <property type="entry name" value="BRISCABRO1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02051">
        <property type="entry name" value="PROTEINF175"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB62561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7143" checksum="23FC45E670B140E2" modified="2019-05-08" version="1" fragment="single">MPQGCVGGKVGKKMAASVSGYTFSSLVYHHANSPSDHEGFLLGDVKQLETFSISDSQISNTELLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP48</accession>
    <name>A0A401NP48_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01005243">
        <property type="protein sequence ID" value="GCB62629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP48"/>
    <dbReference type="STRING" id="75743.A0A401NP48"/>
    <dbReference type="OMA" id="RCTIANM"/>
    <dbReference type="OrthoDB" id="10053642at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000088">
        <property type="entry name" value="Receptor protein-tyrosine phosphatase LAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF430">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="256"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="433"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB62629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="524" mass="60361" checksum="05FD841FF35C29FF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NR34</accession>
    <name>A0A401NR34_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001305">
        <property type="protein sequence ID" value="GCB63317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NR34"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8181" checksum="8501A3A251A43251" modified="2019-05-08" version="1">MPDVGSFTTFPPNISPLTGETGTSPSDSRDSRPSISSDRTRRLHIGKELGQKETRTTLERTFPSTTDYTDFCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NR47</accession>
    <name>A0A401NR47_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004001">
        <property type="protein sequence ID" value="GCB63335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NR47"/>
    <dbReference type="OMA" id="FCQTTEC"/>
    <dbReference type="OrthoDB" id="9944561at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="115" mass="12813" checksum="621350370DFA325A" modified="2019-05-08" version="1">MGFPGVPAFQWNEWEPWVCMCDIGKQGRIRYFVVSSETAKRNVDLEEFWQDKPCSLADCKFCQTTECPIAEVGETAASRFGRRPPRPAAGSLRIPDTNPALANSYDSLPVIDDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRL9</accession>
    <name>A0A401NRL9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 255A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein FAM70A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0009677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM255 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004018">
        <property type="protein sequence ID" value="GCB63515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRL9"/>
    <dbReference type="OMA" id="GFCPSTT"/>
    <dbReference type="OrthoDB" id="10034004at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028014">
        <property type="entry name" value="TMEM255"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33721:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 255A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33721">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 255B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14967">
        <property type="entry name" value="FAM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="143" mass="15770" checksum="EB5168AAE7032387" modified="2019-05-08" version="1" fragment="single">YNDVGSCQEVVHLYHLLWSSTILNIVGLFLGIITAAVLGSFKDMQTPTASRIAYAPEPPPPPIMYDPGQQVLAYTNFYPGPPHLPPYSPYDIQHPSIFSASTPSDDSQSISQSASSYMWPPNTPPRYSPAYFPPDEKPPPYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT10</accession>
    <name>A0A401NT10_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0000226</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000040">
        <property type="protein sequence ID" value="GCB64021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NT10"/>
    <dbReference type="OMA" id="ICEHMAY"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001810">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000008">
        <property type="entry name" value="Dynein axonemal heavy chain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000667">
        <property type="entry name" value="Dynein axonemal heavy chain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000219">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000411">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="382"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="932"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1633"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1946"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB64021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2830" mass="323116" checksum="9865CD16D22E078A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTD8</accession>
    <name>A0A401NTD8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1 C-terminal OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000043">
        <property type="protein sequence ID" value="GCB64117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTD8"/>
    <dbReference type="STRING" id="75743.A0A401NTD8"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032199">
        <property type="entry name" value="RMI1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16099">
        <property type="entry name" value="RMI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ-mediated genome instability protein 1 C-terminal OB-fold" evidence="2">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="141" mass="15929" checksum="1EA100024749A635" modified="2019-05-08" version="1">MESQTPEISREFQSENRKLLDYNDEDFNEFPLNELDDDLSLQDEIHADIEPGEAMIQPPKSHKSLEEPPRGKKLDVITVVEIKGFIVTLLNKLTSNGDLWSIKARISDGTAYMDAEFGDDILRSLIGFSVAEMRVSIKCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUC4</accession>
    <name>A0A401NUC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0011761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with LYAR and RPL23A. Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005459">
        <property type="protein sequence ID" value="GCB64488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUC4"/>
    <dbReference type="STRING" id="75743.A0A401NUC4"/>
    <dbReference type="OMA" id="YHNNDTE"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="187"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB64488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="691" mass="79002" checksum="D3F7E411A3D513D1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXI0</accession>
    <name>A0A401NXI0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SLAIN motif-containing protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLAIN motif-containing family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005579">
        <property type="protein sequence ID" value="GCB65588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXI0"/>
    <dbReference type="STRING" id="75743.A0A401NXI0"/>
    <dbReference type="OMA" id="DQANRWR"/>
    <dbReference type="OrthoDB" id="6347145at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026179">
        <property type="entry name" value="Slain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22406">
        <property type="entry name" value="NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22406:SF5">
        <property type="entry name" value="SLAIN MOTIF-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15301">
        <property type="entry name" value="SLAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="62903" checksum="944BD3B4265B5041" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXV2</accession>
    <name>A0A401NXV2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004221">
        <property type="protein sequence ID" value="GCB65702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXV2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="88" mass="10612" checksum="68B6E2C83F02FB54" modified="2019-05-08" version="1">MDRELCYGQRAVLWTESCVMDRELRYEQSALIWTESCDIYRARAVMWTESCVMDRELFYEQGAVIWTESCDMDRELRYGQSCVMDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY33</accession>
    <name>A0A401NY33_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0007789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002881">
        <property type="protein sequence ID" value="GCB65802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY33"/>
    <dbReference type="STRING" id="75743.A0A401NY33"/>
    <dbReference type="OMA" id="ALSKYMW"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB65802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="221" mass="24715" checksum="744C73726573CFB2" modified="2019-05-08" version="1">MKRKISKCIDPLYSEPWLQSVSLNRRIVKDGFHRELVMDVELGEGAHQGCCIMIKAQLPQGLYVDPFELASLREHKGEEIFIQDEINIEAPEYLSTAHTIVVYLKPGPKHSGHFTGTVPVHVRYHRPTDTEEATALVTLANPQLMIRCQESNPLMENWKLCVSEAPCSANSSSTCSWMNVNYRNVVETLTLQVPVGQKKDVPAVITATVTGAVKSCLWNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYG9</accession>
    <name>A0A401NYG9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0000492</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000095">
        <property type="protein sequence ID" value="GCB65913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYG9"/>
    <dbReference type="STRING" id="75743.A0A401NYG9"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF236">
        <property type="entry name" value="PROTOCADHERIN GAMMA-C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019471419" description="Cadherin domain-containing protein" evidence="14">
        <location>
            <begin position="21"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="125"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="233"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="341"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="446"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="560"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB65913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="817" mass="90484" checksum="D5197DA3E2D33802" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZT4</accession>
    <name>A0A401NZT4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008282">
        <property type="protein sequence ID" value="GCB66363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZT4"/>
    <dbReference type="STRING" id="75743.A0A401NZT4"/>
    <dbReference type="OMA" id="SPQHRRI"/>
    <dbReference type="OrthoDB" id="9950569at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="4">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB66363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="286" mass="30002" checksum="1D1030AAA6E9A51C" modified="2019-05-08" version="1">MADTQKVEDMGDFTVEKAIAKKRKQHQVPRSSPQHRRIKKAAGPTVTQRILQLAAATKERRGISLAALKKALSVKGYDVNRNNTRVNRTVKQLVRNGSLVQTSGVGASGSFRFNRSQMRPDTPALGIGGGGLAAAIAAASTPSAGAPLKDDGGPPKKKTSLVGKTGPASSKRSQGGKVTATAARKGRVGAAARRKGGAAKPRKTGAAAAARRKLKGARRPVAGGRGKAGGPRPYGKKKKPLRGGVRKVAVGGVRRRRPPASKPKRSVGRPRKYPPFGLKKGTYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P134</accession>
    <name>A0A401P134_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001526">
        <property type="protein sequence ID" value="GCB66813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P134"/>
    <dbReference type="STRING" id="75743.A0A401P134"/>
    <dbReference type="OMA" id="WIPLKCI"/>
    <dbReference type="OrthoDB" id="5831756at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF8">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10305" checksum="BA9991471C0474C5" modified="2019-05-08" version="1" fragment="single">MSLLCVRVKKASLSGSPDKFNTYVTLKVQNVKSTTIAVRGDQPCWEQDFMFEISRLELGLIVEVWNKGLIWDTMVGNVWIPLKCIRQSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P250</accession>
    <name>A0A401P250_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0008018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003000">
        <property type="protein sequence ID" value="GCB67208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P250"/>
    <dbReference type="STRING" id="75743.A0A401P250"/>
    <dbReference type="OMA" id="PDHSVQW"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB67208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="444" mass="49885" checksum="93A24961E92FCE27" modified="2019-05-08" version="1">MTLAPKELSSLIGIICEEATSNTFEGLSTAFHHYFAKHDHFRVGSTLVMLLQQADLLPSPQQRLTALYLLWEMYRTEPLAANPFAAVFAHLLNAAPVAEEQEKQLLGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIACMDVGNMPQSVDISGLQLALAERQSELPTQSKASFPSILPDPDPDSSNSGFDSSVATQIIEALVSGPRPPIESHFRPEFIRPAPPLHVCEDELAWLNPTEPDHTIQWDKTMCVKNSTGVEIKRIMAKAFKSPLSAQQQTQLLGELEKDPKLVYHIGLTPVKLPDLVENNPLVAIEMLLKLMQSSQITEYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGENPSEAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2H2</accession>
    <name>A0A401P2H2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007097">
        <property type="protein sequence ID" value="GCB67335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2H2"/>
    <dbReference type="STRING" id="75743.A0A401P2H2"/>
    <dbReference type="OMA" id="QTHISEC"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000070">
        <property type="entry name" value="sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="56"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="346" mass="38277" checksum="4EC75BDC2CF275D9" modified="2019-05-08" version="1" fragment="single">MRTVHNGYWRSALAGKTFELIEHRNRLGTGTNRVLKLGAVFKRNVRKLREKSLNLDLVFLVDESSSVGSANFDNELRFVKKLLSDFPVVPSATRVAIVTFSSRSNVVPRVDYISAPQYHQHKCSLLNEEIPAINYRGGGTYTKGAFQQAAQILRHSRANSTKVVFLITDGYSNGGDPRPIAASLRDLGVEIFTLGIWQGNIRELQDMASHPKEEHCYILHSFAEFEALARRALHEDLPSGDYIQEDRGRCSFLCDVGHDCCDEMASCKCGTNTGQYECICEQGYYGKGLQHECTACPSGTYKAEAKPGGLSTCLHCPNDNYTSLPGSTSIKDCICKEGFKAVGQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2N4</accession>
    <name>A0A401P2N4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003018">
        <property type="protein sequence ID" value="GCB67409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2N4"/>
    <dbReference type="STRING" id="75743.A0A401P2N4"/>
    <dbReference type="OMA" id="FTIRMTR"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18394">
        <property type="entry name" value="BTB_POZ_KCTD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF10">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="237" mass="27415" checksum="517F880A898AC961" modified="2019-05-08" version="1">MDNGDWGQAMANPVTLNVGGHLYSTSISTLTRYPDSMLGVMFRGDFPTAKDSQGNYFIDRDGPLFRYILNFLRTAALTLPHGFKEIDLLKKEADFYQIEPLIHCLNDPKPLYSLDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDFQVSFTFGPCDYHQEVSLRVHLMEYIAKQGFTIRMTRVHHMSERANENTVEHNWTFCRLARKTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3N3</accession>
    <name>A0A401P3N3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003050">
        <property type="protein sequence ID" value="GCB67765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3N3"/>
    <dbReference type="STRING" id="75743.A0A401P3N3"/>
    <dbReference type="OMA" id="SSHVHCT"/>
    <dbReference type="OrthoDB" id="8196042at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000066">
        <property type="entry name" value="ETS-related transcription factor Elf-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022084">
        <property type="entry name" value="TF_Elf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF10">
        <property type="entry name" value="ETS-RELATED TRANSCRIPTION FACTOR ELF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12310">
        <property type="entry name" value="Elf-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ETS" evidence="11">
        <location>
            <begin position="237"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB67765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="634" mass="68383" checksum="392DE5C19BAD2AF1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4H2</accession>
    <name>A0A401P4H2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000166">
        <property type="protein sequence ID" value="GCB68029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4H2"/>
    <dbReference type="STRING" id="75743.A0A401P4H2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="79" mass="9133" checksum="FA6D806E1E3F1C89" modified="2019-05-08" version="1">MRGASILCCAVAYRMNSSGRSRRSLGSADKKESLQKRLESSKLKLTQRFCHKERFNQHECAVNEQPLPRPRPRSLSLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4L7</accession>
    <name>A0A401P4L7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 164</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003080">
        <property type="protein sequence ID" value="GCB68081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4L7"/>
    <dbReference type="OMA" id="TMSRYSL"/>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31976" checksum="D50CED92B700DF2F" modified="2019-05-08" version="1">MSISELGCFTLDTIYGGVDPNITGNGGEECAAFLSHTQRALETVLMISLSLLQIVLSYRKIRGDFRQHWTPGALSQETLGKNLLQAALCLTFGLEIGFKCATKTLIYLLNPCHVVTALQIFLLACPPCPAVVNLFRLHVHMLNGPLLALLFPVVNTRLLPFETEVYYIQHILMYVVPLYLLNKGGVYKPEPLGNFWWPLLATGVLFLYHYTILQALGLITAVNLNSMLCPAVSDPFHGPFYRMWASFHQTVLLLVHGKLIILLSHIMSLLTRDVSNVLQQPLQKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4S2</accession>
    <name>A0A401P4S2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0000823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000171">
        <property type="protein sequence ID" value="GCB68122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4S2"/>
    <dbReference type="STRING" id="75743.A0A401P4S2"/>
    <dbReference type="OMA" id="QWKVTDE"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB68122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="197" mass="22258" checksum="FB16DDF49846B94A" modified="2019-05-08" version="1">MALNCVRLLGSWSRSRVRAAVSALSSAARYQSSQSSVIQPRKEAITSLSKPPWSEVELPDPAEEAKHHIEVVQNVKTLISTGAYGRLFAVVHFASRQWKVTSEDLILIENHIEADCGDRIRLEKVLLVGGGDFTLIGRPLLGRDLVRVEATVIEKTESWPKIHFRFKRRKRYRRTRINVQPQTVLRINTIEIAPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5G1</accession>
    <name>A0A401P5G1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005872">
        <property type="protein sequence ID" value="GCB68357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5G1"/>
    <dbReference type="STRING" id="75743.A0A401P5G1"/>
    <dbReference type="OMA" id="NIFSADX"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="134" mass="14984" checksum="08EA49CBF6D18510" modified="2019-05-08" version="1">MKLLVLGATGNTGQFLVRQALEQGHVVKAVVRTTSKLTIQHENLTVVKANIFSADSLVEHFNEQDVIMSCLGFPISLFSEVTGYTESIKAIVLAMREAKVTRIIAMASWYTKRESVLDYMHIYNGSCQCKLVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5Q1</accession>
    <name>A0A401P5Q1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">adenylate cyclase</fullName>
            <ecNumber evidence="20">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0005301</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19 20">Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="22">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="22">Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20 23">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="20"/>
    <dbReference type="EMBL" id="BFAA01001636">
        <property type="protein sequence ID" value="GCB68438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5Q1"/>
    <dbReference type="STRING" id="75743.A0A401P5Q1"/>
    <dbReference type="OMA" id="LIMPKTA"/>
    <dbReference type="OrthoDB" id="10035433at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000003">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000020">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030672">
        <property type="entry name" value="Adcy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 20 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 20 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0464">Manganese</keyword>
    <keyword evidence="16 20 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
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        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
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        <location>
            <begin position="277"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="25">
        <location>
            <begin position="865"/>
            <end position="1010"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="287"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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            <position position="282"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
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            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="917"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="997"/>
            <end position="999"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <begin position="1004"/>
            <end position="1008"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="1044"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053200"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB68438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120469" checksum="32CAB289704F663C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6M0</accession>
    <name>A0A401P6M0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Family with sequence similarity 168 member B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM168 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000194">
        <property type="protein sequence ID" value="GCB68774.1"/>
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        <property type="entry name" value="TCRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="19841" checksum="4D713D1DF761F10E" modified="2019-05-08" version="1">MNPVYSSAASGVPYANPKGIGYPAGFPMGYAAAAPAFSPTMYAGTNPAFPTGYTPGTPYKVSCSPTSGAVPSYSSSPNPYQTAVYPVRSAYPQQNPYAQQGTYYTQPLYAAPPHVIHHTTVVQPNGMPAAMYPQPIPSPRANGVAMGMVAGTTMAMSAGTLLTHSPTPVASHPAYRTPGTPTYNYVPSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7A1</accession>
    <name>A0A401P7A1_SCYTO</name>
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        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">scyTo_0008318</name>
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    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003155">
        <property type="protein sequence ID" value="GCB69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7A1"/>
    <dbReference type="STRING" id="75743.A0A401P7A1"/>
    <dbReference type="OrthoDB" id="42382at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06758">
        <property type="entry name" value="PDZ2_PDZD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="170"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="351" mass="38122" checksum="9A5B0BF9C0891D1F" modified="2019-05-08" version="1" fragment="single">LSAAQIRSCYLADQCWNGGYIYLIMLRRIKRKAPLPPSNGSGSELTTGSGNSEPSGSPAQNGKRTRKFGVISRSSLNRDSQESRESHSSEQENGYHVSMEAECSKAEGIDSRCDPNDSNAAVDRCTEEQLSNGTSARPTAQYRTRLSETGQTDSRQSGHSTQREGCQIWKMHMVKGSDGLGIQITGGRGSKRSPHGIIVTYIEEGGAAQRDGRLKSGDELLMINGQSLVGLSHQEAVAQLRSAAGLVQLVVASRDESEIHFQKFPSTSLPDLVTNFVVADNSPSPTENKENVKPNCEDVAADCHVHQRPESVSETEKGDDRERVNASQPSCRSPTPGSSVMKFRSRSQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8S9</accession>
    <name>A0A401P8S9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0001075</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01000229">
        <property type="protein sequence ID" value="GCB69561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8S9"/>
    <dbReference type="STRING" id="75743.A0A401P8S9"/>
    <dbReference type="OMA" id="ECYLIAF"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16796">
        <property type="entry name" value="RING-H2_RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000036">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000099">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="296"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB69561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="395" mass="44657" checksum="B4E4373704B1811D" modified="2019-05-08" version="1" fragment="single">VLEQFLKMILPLGLLILSASQIHVSFMVYFVAFLHLWPVEGEIIAHSIDNQTQNFDDLPSRFGYRLPKDGLKGFLVYSRPKNACEPIISPPMTDNSSINYIVLIRRFDCNFDIKVLNAQQAGYKAAIVHNVDSEDLISMGSNDVDIFKQITIPSVFIGEATAKYLMEEFSYLRGGHIVILPDFSLPLEYYLIPFLIIVGICLILIAVFMISKFIQDRHRARRNRLRKDQLKKLPVHKFKKGDEYEVCAICLDEYEEGDKLRILPCSHAYHCKCVDPWLTRTKKTCPVCKQKVVASQGESDSETDDVDSSHEENDDASENTPLLRSSLASTSAHSFGTMSESRSRQEAVESSEYEEEGDSSEAEDGVNEETVVQMQQENPEAIVEERGTRESAAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9M2</accession>
    <name>A0A401P9M2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0001142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000243">
        <property type="protein sequence ID" value="GCB69851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9M2"/>
    <dbReference type="STRING" id="75743.A0A401P9M2"/>
    <dbReference type="OMA" id="RHDHSKI"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF27">
        <property type="entry name" value="SERPIN H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019040220" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="38"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="404" mass="46316" checksum="689DE49A63B10558" modified="2019-05-08" version="1">MEMKLVILSLLLAVVTADPMMLKEHSSMLADSTINLALNLYKTMVKDQKLSSENLLFSPVVVASSLGVMSLGAKDKTAKQVKSLLNINLRDDVLHPTFSELFNEISNETTRNTTWKIGSRLYGPSSVKFRDDFVQKSKTHYRHDHSKISFRDKRNTIQSINEWASQTTNGKLGEITNDVSGVDGAFFVNAMYFKPHWEERFHETMIDKRGFMVMRTHTVSVPMMHRTGLYNYYEDEVNKVQIVEMPLAHKYSSMVLIMPRYVESLERVEKLLTKEQLNTWFSKLQKRAVGISLPKVNIEVSHDLQKHLQELGLTEAVDKNKADFSGITGKKDLHLSNMFHATAFEWNIEGNPCETDLHAHEEMRSPKLFYADHPYIFLVRDNKTNAILLIGKLVKPKGNNHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9N7</accession>
    <name>A0A401P9N7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0012497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006051">
        <property type="protein sequence ID" value="GCB69839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9N7"/>
    <dbReference type="STRING" id="75743.A0A401P9N7"/>
    <dbReference type="OMA" id="AEDERMF"/>
    <dbReference type="OrthoDB" id="8908372at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07699">
        <property type="entry name" value="IgC1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000283">
        <property type="entry name" value="Immunoglobulin kappa constant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019305584" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="240" mass="25823" checksum="0AEB2898AA5F6978" modified="2019-05-08" version="1">MSEWLRVLAALTLCLQCTNAGPVLTQPASISTSLGKTVVITCTLSGGSMSSDYTSWYWQKPGSAPKFVWRDYDSSRGSGIPDRFTGSRDTSRNVMHLTISNVKAEDVADYYCGSWGGSPALYTFGKGTELNLGDPRAPSVSVLPPSPDQIKGKDTATLVCFLNGFKPGAAEIEWTVDGSVRGNGVETSRIQQEADNTFSVSSYLTLSAAEWNSHELYSCVVKHEALANPLKTSISRSSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PA41</accession>
    <name>A0A401PA41_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006069">
        <property type="protein sequence ID" value="GCB69964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PA41"/>
    <dbReference type="STRING" id="75743.A0A401PA41"/>
    <dbReference type="OMA" id="EMITIRA"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000002">
        <property type="entry name" value="Arylsulfatase family member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000007">
        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF69">
        <property type="entry name" value="ARYLSULFATASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019253224" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB69964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="559" mass="62846" checksum="F40847E3C8ADF3C5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAS0</accession>
    <name>A0A401PAS0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0012571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006100">
        <property type="protein sequence ID" value="GCB70213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAS0"/>
    <dbReference type="STRING" id="75743.A0A401PAS0"/>
    <dbReference type="OMA" id="VQIGSWK"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000009">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB70213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="175" mass="19461" checksum="B6037D0B0BAEC04D" modified="2019-05-08" version="1" fragment="single">MLVLVLGDLHIPHRCNTLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQLDVDILISGHTHKFEAFEQESKFYINPGSATGACNALEGNIIPSFVLMDIQASTVVTYVYQLISDDVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCS9</accession>
    <name>A0A401PCS9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-2A adrenergic receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-2A adrenoreceptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0010886</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004792">
        <property type="protein sequence ID" value="GCB70927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCS9"/>
    <dbReference type="STRING" id="75743.A0A401PCS9"/>
    <dbReference type="OMA" id="FFTYMLM"/>
    <dbReference type="OrthoDB" id="5975661at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004938">
        <property type="term" value="F:alpha2-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051379">
        <property type="term" value="F:epinephrine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006940">
        <property type="term" value="P:regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019229">
        <property type="term" value="P:regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15321">
        <property type="entry name" value="7tmA_alpha2B_AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000207">
        <property type="entry name" value="ADRA2B_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF24">
        <property type="entry name" value="ALPHA-2A ADRENERGIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01103">
        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00559">
        <property type="entry name" value="ADRENRGCA2BR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="44"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="218"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB70927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="404" mass="45405" checksum="915FB68ADAC94B49" modified="2019-05-08" version="1">MGEDLTGSSYNRSSNSSEPQGYTLQAAIVFTAVVSLIMMVTIFGNVLVMIAVFTSRGLRAPQNLFLVSLAAADILVATLVMPFSLAKELMGYWYFGEVWCEIHLALDVLFCTASIAHLCAISLDRYWSITQAIEYNLKRTPKRIKCIIVTVWVMAAVISFPPLITNGNKQHSEEHPECEINTEVWYIISSCIGSFFAPCIIMILVYVRIYQIAKLRTRHPPGKQRAGEAQQRLNGLRQSPKAMNGEQNGTQAAEANGFDGEDSSSSEHQGAHCKAKRKKAQPPKARGKVQSVRGKVVSSLVRAEDTGTAKGRWKGRQNREKRFTFVLSVVIGVFVVCWFPFFFTYSLTAICPELCPVPPTLFKFFFWFGYCNSSLNPLIYTIFNQDFRKAFKKILCRGNRRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCW3</accession>
    <name>A0A401PCW3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000319">
        <property type="protein sequence ID" value="GCB70973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCW3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019108142" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8346" checksum="C702554D4B9493A5" modified="2019-05-08" version="1" fragment="single">TCGFGVCVCACVLLSRLINRLQVKQDDEISYCHAGVVLPCIHFKCIPVVDELPFKGAFPSKPARILWSQQVVSVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDB6</accession>
    <name>A0A401PDB6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Folate receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folate receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004818">
        <property type="protein sequence ID" value="GCB71099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDB6"/>
    <dbReference type="STRING" id="75743.A0A401PDB6"/>
    <dbReference type="OMA" id="RNERIMH"/>
    <dbReference type="OrthoDB" id="567542at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004269">
        <property type="entry name" value="Folate_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517">
        <property type="entry name" value="FOLATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517:SF14">
        <property type="entry name" value="FOLATE RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019091985" description="Folate receptor-like domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="5">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB71099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="181" mass="20591" checksum="9D36AE93F176284E" modified="2019-05-08" version="1">MLLLVLGLTLTVTAAKDILNICMDGKHHKTQPGFEGKLYKQVDQTWRNERIMHVPICKTDCEEWWADCREDHTCKVNWHKGWDWSSGINKCPTNSKCQKFSQVFPTPQDLCEKLWSNSYQYTQHDRGSGECIVMWFNSALMDNPNVAVAQHYAIQMGLIASASSAKLTVPLFLALLASDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDY5</accession>
    <name>A0A401PDY5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone deacetylase</fullName>
            <ecNumber evidence="3 12">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0001526</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 12"/>
    <dbReference type="EMBL" id="BFAA01000347">
        <property type="protein sequence ID" value="GCB71322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDY5"/>
    <dbReference type="STRING" id="75743.A0A401PDY5"/>
    <dbReference type="OMA" id="QHPTCWG"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10164">
        <property type="entry name" value="ClassIIa_HDAC5_Gln-rich-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10007">
        <property type="entry name" value="HDAC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000002">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046949">
        <property type="entry name" value="HDAC4/5/7/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024643">
        <property type="entry name" value="Hist_deacetylase_Gln_rich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364:SF12">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364">
        <property type="entry name" value="HISTONE DEACETYLASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12203">
        <property type="entry name" value="HDAC4_Gln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037911">
        <property type="entry name" value="HDAC_II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase glutamine rich N-terminal" evidence="19">
        <location>
            <begin position="62"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="18">
        <location>
            <begin position="684"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="187"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="517"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1073"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1073"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="813"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Contributes to catalysis" evidence="15">
        <location>
            <position position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB71322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121042" checksum="BC080D8898514C28" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEE6</accession>
    <name>A0A401PEE6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acetyl-CoA carboxylase kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
            <ecNumber evidence="2">2.7.11.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Hydroxymethylglutaryl-CoA reductase kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0001594</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ATP = O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23172"/>
            <dbReference type="Rhea" id="RHEA-COMP:13692"/>
            <dbReference type="Rhea" id="RHEA-COMP:13693"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20333"/>
            <dbReference type="Rhea" id="RHEA-COMP:13722"/>
            <dbReference type="Rhea" id="RHEA-COMP:13723"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EC" id="2.7.11.31" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01000364">
        <property type="protein sequence ID" value="GCB71489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEE6"/>
    <dbReference type="STRING" id="75743.A0A401PEE6"/>
    <dbReference type="OMA" id="HVMTEVY"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047322">
        <property type="term" value="F:[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000079">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049020">
        <property type="entry name" value="PRKAA1/2_AID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF104">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB71489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="501" mass="56695" checksum="88E62B7F31773B31" modified="2019-05-08" version="1" fragment="single">ENIPSLCNLYIVGQFTSAIITMLFFTRYQVISTPTDFFMVMEYVPGGELFDYICKHGRVEETEACRLFQQIISAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMADGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVANLLMHMLQVDPLKRATIKDIREHEWFKQDLPTYLFPEDPAYDSNVIDEDAVKEVCEKFESTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNEASEFYLASSPPTGSFMDDNGLHIPAGVKAHPERMHPLMADSPKSRCPLDALNTTKPKPMALKKAKWHLGIRSQSKPYDIMAEVYRAMRQLDYEWKVVNPYHLRVRRKNPVTGNNVKMSLQLYQVDNRSYLLDFMSIDDDIMEQKSGSSTPKRSGSAALLYRPRLSTDATATDSQPLTLVGSLPSSLTGCFSSMTPRNGSHTMDFFEMCASLITTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEQ7</accession>
    <name>A0A401PEQ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Runt-related transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003494">
        <property type="protein sequence ID" value="GCB71585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEQ7"/>
    <dbReference type="STRING" id="75743.A0A401PEQ7"/>
    <dbReference type="OMA" id="YLENTHT"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Runt-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.770.10">
        <property type="entry name" value="Signal Protein Aml-1b, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027384">
        <property type="entry name" value="Runx_central_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013711">
        <property type="entry name" value="RunxI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016554">
        <property type="entry name" value="TF_Runt-rel_RUNX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF40">
        <property type="entry name" value="RUNT-RELATED TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08504">
        <property type="entry name" value="RunxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009374">
        <property type="entry name" value="TF_Runt-rel_RUNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="9">
        <location>
            <begin position="105"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR009374-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="519" mass="56972" checksum="D6F0F343C8DD95B3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF20</accession>
    <name>A0A401PF20_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IBB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0008908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003521">
        <property type="protein sequence ID" value="GCB71732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PF20"/>
    <dbReference type="STRING" id="75743.A0A401PF20"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000001">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB71732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9695" checksum="659CA7F90B4E8A84" modified="2019-05-08" version="1">MLSGGGDELERLRHSARGAQSEGDSRFPKAMLSAGKENFRLKSYKNNSLNPDEMRRRREEEGLQLRKQKREEQVDLKLFFAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJJ2</accession>
    <name>A0A401PJJ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0006712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002309">
        <property type="protein sequence ID" value="GCB73303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJJ2"/>
    <dbReference type="STRING" id="75743.A0A401PJJ2"/>
    <dbReference type="OMA" id="QYPETCS"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901317">
        <property type="term" value="P:regulation of flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12018">
        <property type="entry name" value="FAP206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB73303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="639" mass="73138" checksum="B87089F6AEB0FD49" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKE9</accession>
    <name>A0A401PKE9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000692">
        <property type="protein sequence ID" value="GCB73619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKE9"/>
    <dbReference type="STRING" id="75743.A0A401PKE9"/>
    <dbReference type="OrthoDB" id="9908091at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="15807" checksum="2E0E7C8792FE070E" modified="2019-05-08" version="1">MPARALQIIQPRSILAESHNATFGCAYNNTGEGPLEEFRISVHKGEIGLDTEIKRCGQFTQTTLIVLAFTAIFILYSVFITCLHWPLGTTACILRMKEAVDMKCELIHNSDEPATATWTGQRWETGPRQDVEKEPRRTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PL45</accession>
    <name>A0A401PL45_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">REST corepressor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002929</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CoREST family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000762">
        <property type="protein sequence ID" value="GCB73847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PL45"/>
    <dbReference type="STRING" id="75743.A0A401PL45"/>
    <dbReference type="OMA" id="XSNQKIN"/>
    <dbReference type="OrthoDB" id="10064338at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1880:FF:000001">
        <property type="entry name" value="REST corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000033">
        <property type="entry name" value="REST corepressor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049048">
        <property type="entry name" value="REST_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF13">
        <property type="entry name" value="REST COREPRESSOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20878">
        <property type="entry name" value="REST_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="268"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB73847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52724" checksum="2FF3DD29A7DB8E3B" modified="2019-05-08" version="1" fragment="single">ATKYSDKEIGGMLVWSPYHIIPDVKLDEYIAVAKEKHGYNVEQALGMLFWHKHNIEKSLADLSNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKSIASLVKYYYSWKKTRSRTSLMDRQARKLASRNNQDESDDGMEEGAANDITDSDYDPTKETKKEGNPDPPVQVSRVGSVRRELPSLQHRHHPLRSKCRPPKGMYLSQDDVGAMSCNPNAASTILRQLDMELISLKRQVQNAKQVNSALKLKLEGGIEEFRPSESTQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEAEQGTQESNGVSPTSGEEGKPTLISVPAKSPDIEEEVVQSPPASGSAPPTPVTVAVTCVTTINQPPPLLRPVLPAAPALHRQPPPLQQQTRFLQPRPSLNQPPPPLIRPSNPIPPRLNPRPVLQQPPSLIGIQSESHSSSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLJ2</accession>
    <name>A0A401PLJ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Disheveled-associated activator of morphogenesis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0003074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000812">
        <property type="protein sequence ID" value="GCB73990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLJ2"/>
    <dbReference type="STRING" id="75743.A0A401PLJ2"/>
    <dbReference type="OMA" id="SLEFRMH"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000001">
        <property type="entry name" value="Dishevelled associated activator of morphogenesis 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000012">
        <property type="entry name" value="Dishevelled associated activator of morphogenesis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF16">
        <property type="entry name" value="DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="47"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="608"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="2">
        <location>
            <begin position="959"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB73990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="115797" checksum="809471BEF0DBBE18" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN00</accession>
    <name>A0A401PN00_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0003575</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000987">
        <property type="protein sequence ID" value="GCB74485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN00"/>
    <dbReference type="STRING" id="75743.A0A401PN00"/>
    <dbReference type="OMA" id="CESICGI"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB74485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="269" mass="30574" checksum="77FF6FB2AC173549" modified="2019-05-08" version="1">MIENGIKPVYVFDGKPPQLKSGELTKRSERWAEAEKQLAEAQETGDVENIEKFNKRLVKVTKQHNDECKRLLELMGIPYIEAPCEAEASCAALVKAGKEFHLSKALQQSGLTHDRFVDLCILLGSDYCESICGIGPKRAIELIRQHKNIEEIVKNIDSSKYPIPEDWLYKEARQLFLEPEVVDTDSVDLKWLEADEEELVRFMCTEKPFSEERIRKGAKKLLRGRQASTQGRLDDFFKVTLTSAKCKEPEPKGSAKKKAKTGSKFKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNT5</accession>
    <name>A0A401PNT5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001088">
        <property type="protein sequence ID" value="GCB74775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNT5"/>
    <dbReference type="OMA" id="KYNIEIM"/>
    <dbReference type="OrthoDB" id="9942170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="328" mass="37673" checksum="181F3FE6EBD1A831" modified="2019-05-08" version="1">MFTSAKWQRIKSGFRGPEDFYPLKHVSHREWGRGFTLPDSCVLGTNIEFPKVGERPQFSITNLIHVTDSNGVQGILADQCLKKANLKQIGEDLKVQFSWWGVQVSQEDMEKARGAKREAVTKQLNQTMEGAPARDVGSLRDSLLEQFVSSPAFLKVSNYGNFKFTYKLNDLIGEYEKSVCKGNYPEFRVLGTFKYNIEIMHTVVVHPPGVEIFGQCPPLPSEVITREGAEWKWRPESTGSEMRVLIQGGDGSWRVSDCDPDCRRWDFVSFAFYLPDENPEFPLPLELRHVSVCEMERSQRYRPPYTHMSRGEAEEFYLSVLKGYERFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ78</accession>
    <name>A0A401PQ78_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016315">
        <property type="protein sequence ID" value="GCB75282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ78"/>
    <dbReference type="STRING" id="75743.A0A401PQ78"/>
    <dbReference type="OMA" id="SRRIVQW"/>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008344">
        <property type="entry name" value="TRPV5/TRPV6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF23">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01765">
        <property type="entry name" value="ECACCHANNEL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB75282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="230" mass="26549" checksum="69C46D40214E793C" modified="2019-05-08" version="1" fragment="single">NTVLHVLVLQPEKEQAYSMYDLITSLVSEKHHQFVENIVNNDGYTPLKLAAAEGDFVMFNYLVQKQKKIYWTMGTISYCVYDLTNIDTWGDQKSVLDIITTSRNSEVRKLVDAKPVKELLHQKWNSFGYKYFLIWMFSYIMYIIIFTVSSLYRPLKPIPPGLSDNLTIRTQKTLAESYQTKEDYLRLVGELITIIGALVILISEIPYLYRIGPRNYLGNTSIGGPFPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR31</accession>
    <name>A0A401PR31_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Frizzled-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0016443</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009934">
        <property type="protein sequence ID" value="GCB75589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR31"/>
    <dbReference type="STRING" id="75743.A0A401PR31"/>
    <dbReference type="OMA" id="FTARCCL"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000004">
        <property type="entry name" value="Frizzled class receptor 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000053">
        <property type="entry name" value="Frizzled class receptor 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF136">
        <property type="entry name" value="FRIZZLED-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019510708" description="Frizzled-5" evidence="19">
        <location>
            <begin position="26"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="20">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="21">
        <location>
            <begin position="241"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB75589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="580" mass="65306" checksum="59280840DE8E3081" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRB0</accession>
    <name>A0A401PRB0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013805">
        <property type="protein sequence ID" value="GCB75664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PRB0"/>
    <dbReference type="OMA" id="MEMACND"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB75664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="192" mass="21734" checksum="C60D6D06A8346D56" modified="2019-05-08" version="1">MEEERGAILAFMLGFFQISLDECEEMYRKLGTDVFKQNVIVGTMKMGWSHAFYESEPWEKILKERMGEELLIQTARNPKSPKVAAISTIVNKGTPLKAFVFRNYNHLPSVRSHYMGGCQYKLWQAIRASSAAPGYFQEYAIGSNLHQLLLRNGCYGFNGVISEAQSSPIQYSLLTDFIVCSHVRNTCSPKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRP5</accession>
    <name>A0A401PRP5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017717">
        <property type="protein sequence ID" value="GCB75792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRP5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="353" mass="39680" checksum="7E047DAA8DBDDE3A" modified="2019-05-08" version="1">MSGVLASGVPGIWHKECLELLVLGVSCVLVSGVSGVLAPGMSGVTGTGSVWSTGTGCVWSNGTASVWNLAPGVCGILALGVSEVLAPGVSGVTGILSGWSYWHWEWLELLAPECLEYWHRECLESGIWSGWSYWHFECLEYWHRECLEYWHRECLEYWHRECLEYWHRESLVPWHWECQELLVPGVSGALAPGVSGVTGTGIVWHTGTGVSGVLASGVFGIWHREWLELLASGVSGELALGVSGIWHREWLELLASGVSRVLAQGVSGVTGTGYVWRYWYRACLENWHRECLESGIRSVWSYWYWECLMYWYRACLEYWHRECLELLAPGVYGVLAPDVSGIWHRDWLELLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT17</accession>
    <name>A0A401PT17_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015236">
        <property type="protein sequence ID" value="GCB76255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT17"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8810" checksum="95328B9B0AD03C84" modified="2019-05-08" version="1">MDIANKDIADMDIADKDIADKDIADKDIADMDITDMDRRAYERHGYGSLRIRTLRRSTSWIWTLRIRIIADTDHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTT5</accession>
    <name>A0A401PTT5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013983">
        <property type="protein sequence ID" value="GCB76556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTT5"/>
    <dbReference type="STRING" id="75743.A0A401PTT5"/>
    <dbReference type="OMA" id="NGFRETH"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11881" checksum="4C2F65E9F74772E4" modified="2019-05-08" version="1" fragment="single">MVKRKGRAYRRRKRRVSPQRRGSQGLEAAANISHQLDYVQLRKWLKKKGFDDFYLVPANFPDIGRGLMTTKALQPGDLVIKLPEKCLLTTTTVLNSYLGEYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV01</accession>
    <name>A0A401PV01_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine 5'-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010162">
        <property type="protein sequence ID" value="GCB76893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV01"/>
    <dbReference type="STRING" id="75743.A0A401PV01"/>
    <dbReference type="OMA" id="PEMSDSK"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23347" checksum="E8A406742DB86E4D" modified="2019-05-08" version="1" fragment="single">MAANCSSTFKPVTHVIFDMDGLLLDTERLYTLVFEEVCGRYNKKFTWELKATIMGMQSLNAAKIVCEKLQLPLTPEELIKECLLVQERLFVSTSLMPGIERIVTHLSKQKVPIAVATSSSKQMFDLKTTKHKTLFCLFHHIVCGDDPDVKKSKPAPDSFLVCAKRFEPLPPLEKSVNQQRILGSYLTNLPNSDQKRLGQHTASLAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWK0</accession>
    <name>A0A401PWK0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0021109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018134">
        <property type="protein sequence ID" value="GCB77534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWK0"/>
    <dbReference type="STRING" id="75743.A0A401PWK0"/>
    <dbReference type="OMA" id="EMIDVEW"/>
    <dbReference type="OrthoDB" id="6425912at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF192">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB77534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="113" mass="12909" checksum="DDE84B07DD14A24C" modified="2019-05-08" version="1" fragment="single">MSNKEEKQINTEYAVSLLEQLKCFYDQQLLTDIVLIAESTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLQNVDAPTLQIIIRYAYTGNLAINDSTVEQLYETSSFLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWK4</accession>
    <name>A0A401PWK4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein L-isoaspartyl/D-aspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0018482</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01012909">
        <property type="protein sequence ID" value="GCB77511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWK4"/>
    <dbReference type="STRING" id="75743.A0A401PWK4"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000027">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF7">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB77511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="169" mass="18065" checksum="CDC46BB1410F9FA2" modified="2019-05-08" version="1">MHIVGKHAYALELLHDQLYEGAKALDVGSGSGILTSCFARMVGQSGSVVGIEHIKELVNDSINNVKKDDPSLLSSGRIKFLVGDGRQGYPEEAPFDAIHVGAAASTVPQALLDQLKPGGRMILPVGPPGGNQMLEQHDKLANGSTSMKPLMGVIYVPLTDQEKQVPRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX84</accession>
    <name>A0A401PX84_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014255">
        <property type="protein sequence ID" value="GCB77749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX84"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10410" checksum="987EB9153F6A637C" modified="2019-05-08" version="1">MHKLLSFGYADDWFSERKDVKSNKEQSIEKHSVAVKDEVLPEENQPLYRGKRMTGIRGNGKNKVTAENDSFFKIFGEHRQDVYSYIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX86</accession>
    <name>A0A401PX86_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015581">
        <property type="protein sequence ID" value="GCB77726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX86"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="7917" checksum="C9B39C6FF6DF7B73" modified="2019-05-08" version="1" fragment="single">VKRVSLLSDSDKVRQYFVCKSSAGPLSGLLRYGAEREPELPRHPERPHRAKVKMAASVRDKQTVFLPIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXZ8</accession>
    <name>A0A401PXZ8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011685">
        <property type="protein sequence ID" value="GCB77978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXZ8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="142" mass="16009" checksum="7A27B44CC6458B71" modified="2019-05-08" version="1" fragment="single">MPCCQVDIEETVLGLIPRCQEDIEETVLALMPRCQEDTEETVLGLMPRCQGDIEESVLGLIPRCQEDIEETVLALIPRCQEDIEETVLGLKPRCWGGDTEETVMGLMPCCREDNEETVLGLKPHSQEDTEETVLRMKPCCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY69</accession>
    <name>A0A401PY69_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome production factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Brix domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ribosome biogenesis protein RPF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0020066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be required for ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015670">
        <property type="protein sequence ID" value="GCB78089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY69"/>
    <dbReference type="STRING" id="75743.A0A401PY69"/>
    <dbReference type="OMA" id="EWEHRPD"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Brix" evidence="9">
        <location>
            <begin position="74"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB78089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="281" mass="32957" checksum="8118BBDF82F8E5E0" modified="2019-05-08" version="1">MLQLYRTLEQLAARKKRQKEREALGDKAPPKPVPKTIENQRIYDETTVDPNDEEVAFDEATDEFSTYFNRETSPKILITTSDRPRGRTVRLCEQLAKVVPNSHVYYRRGLALKKIIPQCVARDFTDLLVINENRKVPNGLIVSHLPNGPTAHFKMSNARLAKELKRKGKDPTLHIPEVILNNFSTRLGHTIGRMFASLFPYSPQFVGRQVATFHNQRDYIFFRFHRYIFRNEKKVGLQELGPRFTLKLRSLQKGTFDSKYGEYEWVHKRHEMDTSRRKFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYI7</accession>
    <name>A0A401PYI7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0017709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagellar radial spoke RSP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011725">
        <property type="protein sequence ID" value="GCB78166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYI7"/>
    <dbReference type="STRING" id="75743.A0A401PYI7"/>
    <dbReference type="OrthoDB" id="313308at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009290">
        <property type="entry name" value="Radial_spoke_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648">
        <property type="entry name" value="FLAGELLAR RADIAL SPOKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06098">
        <property type="entry name" value="Radial_spoke_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB78166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="115" mass="13180" checksum="D9124A47B4A7F5E9" modified="2019-05-08" version="1" fragment="single">MYDRRVVRGNTYAQNTLPVTAQPDPIELQRQQEIQRRAIARRRAKAQLRTGTPHPVEGRIHTEVQTELYLEELSDRIEEVDVDTQTDAFLDKPPTPLFVPTKTGKDVATQIEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZF3</accession>
    <name>A0A401PZF3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011797">
        <property type="protein sequence ID" value="GCB78515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZF3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9704" checksum="139B51D945F338F1" modified="2019-05-08" version="1">MTETNELLDEDRPIWLLIFEAEVNDDDEAKEDVDQKKVAYATEEEEQDRHSVKSADYIIFSSISLTTPNYFTRVAFLVVSVICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZM7</accession>
    <name>A0A401PZM7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009200">
        <property type="protein sequence ID" value="GCB78604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZM7"/>
    <dbReference type="STRING" id="75743.A0A401PZM7"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="470" mass="53428" checksum="E1869421FFE24D84" modified="2019-05-08" version="1" fragment="single">SQVQFLAWGVVTGILLVTPKKIFFDPYKSHPLVTENGCEDYLFACNMQSLVSVVSHKDVSQMKLCGSPPLRKAPVQSQIQQTGRNTANATQRKSLQVSTTAPPQANTQPTEIKKTDSVPADQEVETSTKLIGTSYSCPDSLCQVDEKLFNEIAGLQDSVTCLALKEPDKTEIKEILPFTSRTKCGGDNLISENGHCYCYEQSIREGKLGPKANYHSSRHPPHMLSEENKPEKLSDSINNTDNKTTSFCEINLSDQGCPEYLWLHTSENTGEKLLYTELSRLKAEEVCSILNTVTEDQFGIYDEKDNKTNARLPALTQKHELKQDLYHSKDDEDKFRLMFLCLKVRLPRKGTNLFQFVVTKPQDMSQDETAEYWFAMSQEKVAELHGYLKHWRPELYLPERMGDTRVDDFVLLDGKSAFPLSEKFFDGLFDEWEIITVEDDPMKRRKDIFDSEFGNMAPVLQGKSNLMKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q070</accession>
    <name>A0A401Q070_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium load-activated calcium channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GEL complex subunit TMCO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Transmembrane and coiled-coil domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0020145</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015833">
        <property type="protein sequence ID" value="GCB78775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q070"/>
    <dbReference type="STRING" id="75743.A0A401Q070"/>
    <dbReference type="OrthoDB" id="342726at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008559">
        <property type="entry name" value="TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917:SF0">
        <property type="entry name" value="CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917">
        <property type="entry name" value="PNAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB78775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8639" checksum="75FE49E5AD777074" modified="2019-05-08" version="1" fragment="single">RQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIIFRNSWVWLLHVQLPNRLGDSWDLHLKQANSHDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1X4</accession>
    <name>A0A401Q1X4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017288">
        <property type="protein sequence ID" value="GCB79350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1X4"/>
    <dbReference type="STRING" id="75743.A0A401Q1X4"/>
    <dbReference type="OMA" id="HTALWEK"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="152" mass="16525" checksum="06D0B18D37346F1D" modified="2019-05-08" version="1" fragment="single">NSSQSAGLVTGGLLFSVVGGKMSEGINFSDDLGRCVVMVGMPFPNINSPELQEKMSYLDKILPKTGGTSPGKLLVENLCMKAVNQSIGRAIRHREDYATIVLLDHRYTRPSILSKLPSWIKGQTHAETSFGPVLKAIGKFFRDKKICGDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2K0</accession>
    <name>A0A401Q2K0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0019567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014690">
        <property type="protein sequence ID" value="GCB79580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2K0"/>
    <dbReference type="STRING" id="75743.A0A401Q2K0"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1080:FF:000001">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suv3 C-terminal" evidence="8">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent RNA helicase SUV3 C-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB79580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="297" mass="33703" checksum="5027BB20568B3877" modified="2019-05-08" version="1" fragment="single">AAGLHPTADQIEMFAYQLPDATLSNLIDIFVSLSQVDGLYFVCNIDDFKFLADMIQHIPLNLRVRYVFCTAPINRKHPFVCTSFLKFARQFSRNEPLTFNWLCRHINWPLTPPKNIKDLVHLEAVHDVLDLYLWLSYRFMDMFPDVNHVRDIQTELDSIIQIGVKNITRLIRASDSISTAATTGFDDVPVRGRIRTNGRINMEGTNTKDQVFSGSRRIRGSKALGYKAVVCKAGTSQRAGDSLSTRLVQQGHLTAELLQQLQEEWSASQVHGPQAQRDSVAQDRDKSTSKGLRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2T0</accession>
    <name>A0A401Q2T0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)</fullName>
            <ecNumber evidence="4">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0016022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01009421">
        <property type="protein sequence ID" value="GCB79702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2T0"/>
    <dbReference type="STRING" id="75743.A0A401Q2T0"/>
    <dbReference type="OMA" id="PNMARQN"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF79">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="12">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB79702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="307" mass="33079" checksum="7D7F3EEB876DE97B" modified="2019-05-08" version="1">MGDLAVGINGFGRIGRLVLRACLDKGISVVAINDPFIDLNYMAYMFKYDSTHGRYRGEVQVDDGKLVVDGQPISVFQCMKPAEIPWGDSGALYVVESTGVFLTVEKASLHLQGGAKRVVVTAPSPDAPMFVMGVNEDKYDPSSMNITTVHAYTATQKTVDGPSSKAWRDGRGANQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPVADVSVVDLTCRLAKSASYAEIKEAVKKASEGPLKGILGYTDHQVVSSDFVGDTHSSIFDAGAGISLNDNFVKLISWYDNEFAYSNRVVDLLNYMFNMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4P2</accession>
    <name>A0A401Q4P2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DnaJ homolog subfamily C member 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0016165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DNAJC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009605">
        <property type="protein sequence ID" value="GCB80331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4P2"/>
    <dbReference type="STRING" id="75743.A0A401Q4P2"/>
    <dbReference type="OMA" id="TERWCWT"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044632">
        <property type="entry name" value="DNAJC25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019259146" description="DnaJ homolog subfamily C member 25" evidence="9">
        <location>
            <begin position="35"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB80331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="298" mass="35406" checksum="15C3BCDED1684B8A" modified="2019-05-08" version="1" fragment="single">ASALTMASVGRRGSRLLLLRLCVASFTLCGRADGLVEGLYCGAVSCYDVLGVARDAGKSDIARAYRQLARRYHPDRYRPTEAEENPEERFLLVATAYETLKYYSWWSSYSEALHYLTTVPKYRIQATEIAKQQGLLNKAKEKGKNRRSKEEIKEEEEEIIKGIIKNNIDIKGGYQKPRLYDILLFQIVLAPYYICSYVIWYCRWIYHFHIKREEYGEEEKLYIIRKNMHMSQGQFDSLEDHQKETFLERKLWLWENFEVYKVEQEEELKKKVASDPRWKRYRRWMKNEGPGRLTFVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7H9</accession>
    <name>A0A401Q7H9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025340">
        <property type="protein sequence ID" value="GCB81321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7H9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="34" mass="3892" checksum="9130913280A96668" modified="2019-05-08" version="1" fragment="single">VRAQYRKCFARMCKAKDTSDSQMDADDTMITMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q841</accession>
    <name>A0A401Q841_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018964">
        <property type="protein sequence ID" value="GCB81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q841"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="46" mass="5369" checksum="61BFA6874D6ADD9B" modified="2019-05-08" version="1" fragment="single">EWEESEADQDHCEESGRRVKQIRITVKQTGRRVKQIMITVKRAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q858</accession>
    <name>A0A401Q858_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021556">
        <property type="protein sequence ID" value="GCB81507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q858"/>
    <dbReference type="STRING" id="75743.A0A401Q858"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="12822" checksum="09D0107EAE5CADF6" modified="2019-05-08" version="1" fragment="single">FVRRYPGSQVSASICSGLSALIVFSNRTYVIEHLEGDKGGRHFVYRPEDLPPAPSGCGVKNAPPESILTDFLQGSHRVKRDLMSEMKYLELVIVTDNAMVSGVALCRLVEVNDELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8D5</accession>
    <name>A0A401Q8D5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021642">
        <property type="protein sequence ID" value="GCB81649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8D5"/>
    <dbReference type="OrthoDB" id="10614450at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="245" mass="27429" checksum="836C0AEFAFEFAE71" modified="2019-05-08" version="1">MLHKLARIELARIELVHKLAHFVMVHKLALHEMVHKLAQHKMVHKLAHFVMMHKLAHLGMLHKLAHFVMVQKLAHLEMLHKLAHFVMVQKLAHLEMVQQLAHIELAHHELVHKDGAAVGTHQAGTPRDGAAVGTHQAGTPRDGAAVGTHQAGTPRDGAAVGTHRAGTPRDGEHKLAHFEMVHTLAHIELALLELPHLELTHLELMHLEKAHKLRHLGLVHKLAHPELGNLELAHRDLAHKLHTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBN9</accession>
    <name>A0A401QBN9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01036298">
        <property type="protein sequence ID" value="GCB82794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBN9"/>
    <dbReference type="STRING" id="75743.A0A401QBN9"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF55">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE LBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="2" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="2" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="2" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13863" checksum="7BF87DBC9019A905" modified="2019-05-08" version="1" fragment="single">HKIRREIVTDQLGVPYSLRTKKEEGKVVELETKDDHLYIKKQVARTPEWEFGGRFGAFFIIFFLPITLVLLLLMCAQEDASVVNFPPPIPAVQTLWSSTALGIFVLWFLFQALLYLLPVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDV5</accession>
    <name>A0A401QDV5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01040126">
        <property type="protein sequence ID" value="GCB83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDV5"/>
    <dbReference type="STRING" id="75743.A0A401QDV5"/>
    <dbReference type="OrthoDB" id="8918696at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="10860" checksum="14278330A2E0434E" modified="2019-05-08" version="1" fragment="single">YGMRYTAKVLKSSLREKFPDASEDELFKVVGNLLYYRYMNPAIVAPDGFDIIDVAAGGGLHTDHRRNLGSIAKLLQHAASSKSIEGETGQLRTINDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEF7</accession>
    <name>A0A401QEF7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01041925">
        <property type="protein sequence ID" value="GCB83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEF7"/>
    <dbReference type="OrthoDB" id="8741746at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11739" checksum="819DB4B7EF38D7EE" modified="2019-05-08" version="1" fragment="single">MIRQTHSSILLVGYQPKNQDVVRWYFLNSKTRKTILHFTTSVIHVNPFYRQRSEFDVVTGSLLLRNLQTQDSGIFEVILNPIESQGLEKGDQISYVELDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG54</accession>
    <name>A0A401QG54_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01065997">
        <property type="protein sequence ID" value="GCB84360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG54"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="40" mass="4708" checksum="A9D464C98A8D5BE2" modified="2019-05-08" version="1" fragment="single">EETVEVKVLEDPDPDVSDSEVTHRLIKRRRRAIDDDDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH35</accession>
    <name>A0A401QH35_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01079406">
        <property type="protein sequence ID" value="GCB84680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH35"/>
    <dbReference type="STRING" id="75743.A0A401QH35"/>
    <dbReference type="OMA" id="DQCEAGW"/>
    <dbReference type="OrthoDB" id="1702031at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="167" mass="17758" checksum="F0B25477E96629A2" modified="2019-05-08" version="1">MKLVGINVKLVGINAKLGGINVEQVGINVKLVGINVKLVGINVKQVGINVKLVGISVKLVGISVKQVGIRVKLVRISVKLVGISVKQVGISVKLVGISVKLVGISVKLVGISVKQIVISEKQFGNSVKLVRITEAGWDQCEAGWDQCEAGWDQCEAGWDQCESGRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK11</accession>
    <name>A0A401QK11_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01182802">
        <property type="protein sequence ID" value="GCB85648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK11"/>
    <dbReference type="OrthoDB" id="386880at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="15369" checksum="63693133F981D55D" modified="2019-05-08" version="1" fragment="single">MPCPGGVGTEPCPGEFVMEPCPGEVGTELCLGEVGMEPCLGEVGMELCPGKTKLDQDGQGLKPEKLNLEARTPEAKENVKYRLWCFEAYLDSAEIPILGPRKLSLLHGRVSHRISATLEKATTYEEAVELLRKRFVKPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKE9</accession>
    <name>A0A401QKE9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferritin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0026451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01198700">
        <property type="protein sequence ID" value="GCB85793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKE9"/>
    <dbReference type="STRING" id="75743.A0A401QKE9"/>
    <dbReference type="OrthoDB" id="9948915at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF54">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0409">Iron storage</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB85793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="48" mass="5526" checksum="9CA1EED6E03D5869" modified="2019-05-08" version="1" fragment="single">LCDFLESHYLDEQVKMIKMLGDHITNLKRLGAPENGTGEYLFDKLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL69</accession>
    <name>A0A401QL69_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01234735">
        <property type="protein sequence ID" value="GCB86082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL69"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="20373" checksum="B5CD1E177DBA344F" modified="2019-05-08" version="1">MVHLVFGTGYCWSLGPGTLCVRDLVQLVCGTWDTWCLGPGTVGVWDLVHSVFATTYTWCLGRGTVGAWDQERLAFGALYAWCLGPGKHVVWDLVHRVFVTWYTGCLGPGRRRFWVPRHVVFGTWYTWCLGPGTLGIWDLVYLVCGTWYTSCLGPGTLGVWKLAHLVYGTWYTWCLGPSTLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM64</accession>
    <name>A0A401QM64_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01294239">
        <property type="protein sequence ID" value="GCB86469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM64"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="58" mass="6205" checksum="DE3EB532604F5989" modified="2019-05-08" version="1" fragment="single">MERAAAERAAVERAAAERAAVERAAVERAAVERAAAERAAVEWATAERAAVEWAAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMN2</accession>
    <name>A0A401QMN2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01329927">
        <property type="protein sequence ID" value="GCB86681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMN2"/>
    <dbReference type="STRING" id="75743.A0A401QMN2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162:SF20">
        <property type="entry name" value="GLUTAMINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="216" mass="25248" checksum="22299F94CE590B9E" modified="2019-05-08" version="1" fragment="single">MRVFAPVTVYMREFVPVTVYMREFVPVAARMREFVPVAAYMREFAPVTVYMRGFVPVAAYMREFAPVTVYMREFAPVTVYMREFVPVAAHMREFVPVAARMREFVPVTVYMREFVPVSARMHEFVPVAAHMHEFMPVTARMSEFVPAAAYMRESVPVTAYMREFMQVAARMREFVPVAAYMREFAPVTVYMREFVPVAARMREFVPAAAYMREFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QN97</accession>
    <name>A0A401QN97_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01354712">
        <property type="protein sequence ID" value="GCB86836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QN97"/>
    <dbReference type="STRING" id="75743.A0A401QN97"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="233" mass="25722" checksum="0B88C6E20081EFA9" modified="2019-05-08" version="1" fragment="single">EGRSEGEGRSEGEGRSEGEGHSESEGRSEGEGRSEGEGHSESEGRSEREGHSEREGRSEGRSEREGRSEREGRSEGEGRSEREGRSEREGHSEGRSEREGRSEREGRSEGEGRSEGEGRSEGEGRSEGEGRSEREGRSEGEGRSEGEGRSEREGRSEGEGRSEREGRSEGVGRSEGEGRSEREGRSEREGRSESEGRSEGEGRSEREGRSEIEGRSEREGRSEREGRSEREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNL8</accession>
    <name>A0A401QNL8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01359737">
        <property type="protein sequence ID" value="GCB86908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNL8"/>
    <dbReference type="STRING" id="75743.A0A401QNL8"/>
    <dbReference type="OMA" id="RKDTISC"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="230" mass="23900" checksum="AFCB3F2ABD3492D9" modified="2019-05-08" version="1" fragment="single">VYTGRSDALTVCTGRSDALTVYTGRSDALTVYTGRSDALTVCTGRSDALSIYTGRGDALTVYTGCSDALTVYTGRSDALTVYTGRSDALTVYTGRSDALTVCTGRSDALTVCTGRSDALTVYTGRSDALTVCTGRSDALTVYTGRSDALTVYTGRSDALTVCTGRSDALTVYTGRSDALTVCTGRSDALTVCTGRSDALTVYTGRSDALTVYTGRGDALTVYTGRSDALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNM7</accession>
    <name>A0A401QNM7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01393791">
        <property type="protein sequence ID" value="GCB87017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNM7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="7834" checksum="67BDFFA83EA7401A" modified="2019-05-08" version="1" fragment="single">KKLAQPVSGCCVTTVPCQAAASLRIRDKLLRHYGSVSSGCVTTVPCQAAASLRIRVKLLRHYGSVTSCCVTTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPR0</accession>
    <name>A0A401QPR0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0028038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01455627">
        <property type="protein sequence ID" value="GCB87345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="EHTEFEH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="15142" checksum="B41FF4A9D9F2AA1B" modified="2019-05-08" version="1" fragment="single">TDSETEQTDSEMEQTDAETEQTDSETEQTDAETEQTDAEAEQTDSETEQTDTDRQRETEQTGTVREQADIERQSTQTQMEQADTEAEQANAETEKTDTERREGETAETQRESRQAQRHRGTEQVTQGCGRQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NFS2</accession>
    <name>A0A401NFS2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0013986</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01007357">
        <property type="protein sequence ID" value="GCB59745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NFS2"/>
    <dbReference type="STRING" id="75743.A0A401NFS2"/>
    <dbReference type="OMA" id="LHIRRET"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14073">
        <property type="entry name" value="STKc_NUAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000226">
        <property type="entry name" value="NUAK family SNF1-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="52"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB59745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="641" mass="72279" checksum="AA7DDBE37809798F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NFW8</accession>
    <name>A0A401NFW8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 13">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0010998</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">PPIases accelerate the folding of proteins during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 13"/>
    <dbReference type="EMBL" id="BFAA01004866">
        <property type="protein sequence ID" value="GCB59842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NFW8"/>
    <dbReference type="STRING" id="75743.A0A401NFW8"/>
    <dbReference type="OMA" id="ESMMEFR"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000002">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051989">
        <property type="entry name" value="FKBP-like_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46046:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46046">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="15">
        <location>
            <begin position="93"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="15">
        <location>
            <begin position="205"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="15">
        <location>
            <begin position="317"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB59842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="500" mass="55511" checksum="6793EA7BE188C954" modified="2019-05-08" version="1" fragment="single">SYDRGSTYNVFVGKGRLIAGMDKALIGMCVNERRFIKVPPHLAYGEEGMSDIIPPGATLFFDVLMLDIWNPEDKVKIDVHSKPGNCSRTVQVSDFVRYHYNGTLLDGTLFDSSHTQQQTYDTYIGIGWLIAGMDEGLLGMCMGEKRTITMPPFLGYGDKGDGKDVASQATLVFHVTLVDFHNPKDSIAIEREFVPDPCSRKTKVGDFVRYHYNGTLMDGTLFDSSYSRNHTYNTYIGKGYVIVGMEEGLLGVCVGEKRTIIIPPHLGYGEEGISGTIPGSAVLVFHIQMIDVHNPSDEIEIKTYHKPSNCTIRSKKGDYVKYHYNATLMDGTKLDSTHNYGKTYNIVLGSGQVVIGMDMGLTNMCVEEKRTIIIPPHLGYGESGVVGEVPGSAVLIFDVEMVEVVTGLPEGYMFVWTSEVSSPDLFQEIDKDENKEVSPEEFSKYILAQVESGQGRLAPGFSPDKIIENMFSNQDRNGDGKISAEEFRLKNEEKTSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGM0</accession>
    <name>A0A401NGM0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007418">
        <property type="protein sequence ID" value="GCB59914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGM0"/>
    <dbReference type="OMA" id="MNQCLCG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB59914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="13696" checksum="99E894F63D737080" modified="2019-05-08" version="1" fragment="single">MHSNSNAIIKDTKKEEQAEEEEEQAEEEEEEQDEEEEEQDDEEEEQDEEEEEQDDEEEEQDEEEEEVEEQDEEEGEQDEEEEEQDKEEEEQDKEEEEEQDEEEEEQDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGM3</accession>
    <name>A0A401NGM3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0011049</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004902">
        <property type="protein sequence ID" value="GCB60025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGM3"/>
    <dbReference type="STRING" id="75743.A0A401NGM3"/>
    <dbReference type="OMA" id="TAVAYMR"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20514">
        <property type="entry name" value="CYCLIN_CCNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000015">
        <property type="entry name" value="Putative cyclin-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000017">
        <property type="entry name" value="Putative cyclin-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB60025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="283" mass="33276" checksum="F447C7C615EE771B" modified="2019-05-08" version="1">MAGNFWQSSHYLQWILDKQDVMKERQKDLKFLTEEEYWKLQIFFANVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLISASTSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLMYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYDLWKNFDDRKEMAAILNKMPKPKPPPNSEGEQGPNGSQNSTYNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHG9</accession>
    <name>A0A401NHG9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007484">
        <property type="protein sequence ID" value="GCB60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHG9"/>
    <dbReference type="STRING" id="75743.A0A401NHG9"/>
    <dbReference type="OMA" id="IRKMPRD"/>
    <dbReference type="OrthoDB" id="10256467at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="173" mass="20182" checksum="3B99C50A09730CF3" modified="2019-05-08" version="1" fragment="single">VMLFEHTVFPALSLNFLSLQLATKQEELESMFLKVEGIEGQLVVAQNQSHFFRERTKQQEHILVQATTFLQGMRIELVVLREEVRDNLMIWGPFNKTLTHCLEATSSSVQMEMFHLQENLKKSNQEVDFIQQQVRELQLSSDTIALQTHQIHVLEQKEAELQIRCCDLQKQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI31</accession>
    <name>A0A401NI31_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPRY domain-containing SOCS box protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0003953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPSB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001126">
        <property type="protein sequence ID" value="GCB60526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI31"/>
    <dbReference type="STRING" id="75743.A0A401NI31"/>
    <dbReference type="OMA" id="MFHIDYS"/>
    <dbReference type="OrthoDB" id="5951542at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000018">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="129"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="317"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB60526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="399" mass="44470" checksum="2C2A6B9C1F79D8CA" modified="2019-05-08" version="1">MGRKAGRRGRGEAEIQVWLSGKSIYRGSALATSQGVNQGFRSTMSRRTRNNRAWRYVYSGVRDAEAVAVVMPDGSVGPGPGYDSDGQHSDSDSEPEFHLPPSIPTALPVTGESYCDCVSQSDARYCGGMRSFHRMKDCHCGEEDEYFEWMWDDSTKSAATLLSCENREVNFHMDYSCGTAAIRGDKEMSEGQHFWEIKMTSPVYGTDMMVGIGTTDVKLDKFRHTFCSLLGKDENSWGLSYTGVLHHKGAKIHFSTRFGQGSIMGVHLDTWHGTLTFFKNRKCIGVAATKLQNKKFFPMVCSTAARSSMKVIRSCFSPTSLQYLCCLRLRQLLPDHNDKLEVLPLPPGLKRMLCNRLGWVLSMNHEGSGKETACSSSSSDSFSSSVDPEACQRKRCRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIP2</accession>
    <name>A0A401NIP2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001139">
        <property type="protein sequence ID" value="GCB60736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIP2"/>
    <dbReference type="STRING" id="75743.A0A401NIP2"/>
    <dbReference type="OMA" id="DTIQMED"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB60736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24604" checksum="4DF643D400FE8E2D" modified="2019-05-08" version="1" fragment="single">MNRNFMVEVSSISDKQDGGIISSGLTKKLNLKGNRITDLIPETFDGLSRLKYLFLSYNQIRFIADYMFQPTPEIELIDISNNHLYAIQRDLFRTKHGLPSLKVLDLSNNNILILGPGAFSQLSSLHFLNVSDNYLSLIGNGAFDHLSSIIYLDLRATSISLDILKGILESTINIVNLYISHTLKCCLCKYPHLDKLILARDVEINCKNIFCTISLMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIR8</accession>
    <name>A0A401NIR8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002423">
        <property type="protein sequence ID" value="GCB60764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIR8"/>
    <dbReference type="OMA" id="KCAPDIN"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="15834" checksum="9A13E9AA3C00E4D5" modified="2019-05-08" version="1">MILVARIRNGLRINGPIIDESETIPDHSQLLDAKELDTAPDEVVTSEPGPSETVGVLEAAAEAGLSSVAAELVIDEPEAEISEASMEAISPSDADAQPSEAEEQTEGETGERLESEINVDTGMEELETKEEATEVAEAPEVTEMKSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKS5</accession>
    <name>A0A401NKS5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0007058</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for the neuromedin-U and neuromedin-S neuropeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002485">
        <property type="protein sequence ID" value="GCB61465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKS5"/>
    <dbReference type="STRING" id="75743.A0A401NKS5"/>
    <dbReference type="OMA" id="QLHVPCR"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15358">
        <property type="entry name" value="7tmA_NMU-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005391">
        <property type="entry name" value="NeuromedU_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01566">
        <property type="entry name" value="NEUROMEDNU1R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="75"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB61465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="409" mass="47444" checksum="1B3602C780B821F2" modified="2019-05-08" version="1">MDYLQNRSAFLQTVYQYFCNATSQEHNLTWNGSVPEDFFLSNEELLFKYLGPRRSTFFTPVCMMYLCIFLVGALGNALTCTVIAKHKVMRTPTNYYLFSLAISDLLVLILGMPLELYEMWRNYPFLLGQAGCHFKTFLFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVILTVWLISLCSAIPNTSLHGIYYLSTPFGEHIEESAICVLLKPAWMYNLIIQVTTVLFFFAPMITISILYLLIGLQLKREKAFSEFKPGAGHCNYQTARMEQEKARRRQVTKMLFVLVIVFGICWAPFHTDRLMWILINNWTGELHRLYQYVHIVSGVFFYFSSAVNPILYNLMSTRFREMFKEVMCRRKFQSSKPRWYSASVTRVTTRSTVLESSPCNGIPLSDIEDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLC3</accession>
    <name>A0A401NLC3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0014367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007685">
        <property type="protein sequence ID" value="GCB61676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="DTISCMQ"/>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032771">
        <property type="entry name" value="DUF4527"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36866">
        <property type="entry name" value="CHROMOSOME 4 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36866:SF1">
        <property type="entry name" value="GENE 1043-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15030">
        <property type="entry name" value="DUF4527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1922"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="971"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1688"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="210"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="375"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="597"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="752"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1359"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1567"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1774"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="978"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB61676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2028" mass="234023" checksum="8B94A67A5EB39BF6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM06</accession>
    <name>A0A401NM06_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0007125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002528">
        <property type="protein sequence ID" value="GCB61879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM06"/>
    <dbReference type="STRING" id="75743.A0A401NM06"/>
    <dbReference type="OMA" id="CDIRTNQ"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB61879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="428" mass="48178" checksum="8088C6F04176982A" modified="2019-05-08" version="1">MVRMADKEVYDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTVQWLPDVTRPEGKDYSVHRLVLGTHTSDEQNHLVIASVQIPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPTSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAGPKEGKIVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEEPDTPASELESQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN07</accession>
    <name>A0A401NN07_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002561">
        <property type="protein sequence ID" value="GCB62253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN07"/>
    <dbReference type="STRING" id="75743.A0A401NN07"/>
    <dbReference type="OMA" id="DARRINM"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF899">
        <property type="entry name" value="ASTACIN-LIKE METALLOENDOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="19180" checksum="DF251260D972E00E" modified="2019-05-08" version="1">MHALGFYHENCRIDRDDHIEVEMANIQQESENNFKVQESNNLVTDYDYVSVMHFGRFAFSKSPGLPTIVPKPDPNVQIGQFMGLSEIDVLKINTLYQCRKCNIHIYFFEIYSFKTLADFNLLLQFKRDSNYMILRCYVVPESETQIKLPQYRMLGVPNCRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN46</accession>
    <name>A0A401NN46_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005204">
        <property type="protein sequence ID" value="GCB62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN46"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13944" checksum="83BD95EA3D1DA1A1" modified="2019-05-08" version="1">MDSGLKPEKLNLDARSPEATENFKYWLRCFEAYLNSSETEVDGPRKLSLLHARMDHRLSSVIEKATTYETAVKILQKRFVKPINEVHARYLPRPAASAPGKLWMNTWRDSPRSPGTETIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPV7</accession>
    <name>A0A401NPV7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000013">
        <property type="protein sequence ID" value="GCB62910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPV7"/>
    <dbReference type="STRING" id="75743.A0A401NPV7"/>
    <dbReference type="OMA" id="MKINCEC"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB62910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="233" mass="27205" checksum="68B30E9F2B8CA3D4" modified="2019-05-08" version="1">MKFKMPNERKLHERKHDGKKMVTFDNFCNPMALLRSLSIPLTLANIDWVLLLFSALSYPCSFKECQLVATTWTQLQKHLKTHPIEYSCAKCEKKFKGASALRRHKQIHAVQGSERVCPMEDCKLNFRTAFNLEHHIRKDHFKILEYKCNFPDCQKAFAMKINCECRQKRPQGRRNPVIEEKLTGLFNEKLFKSKSKIESDLSGLFNERKIPHPVTAEANLVRLFENQLSLPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQA3</accession>
    <name>A0A401NQA3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">N-acetylglucosamine-1-phosphotransferase subunits alpha/beta</fullName>
            <ecNumber evidence="17">2.7.8.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">GlcNAc-1-phosphotransferase subunits alpha/beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Stealth protein GNPTAB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0011552</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-[alpha-D-mannosyl-(1-&gt;2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1-&gt;2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13581"/>
            <dbReference type="Rhea" id="RHEA-COMP:14507"/>
            <dbReference type="Rhea" id="RHEA-COMP:14508"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:140357"/>
            <dbReference type="ChEBI" id="CHEBI:140369"/>
            <dbReference type="EC" id="2.7.8.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the stealth family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.17" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01005290">
        <property type="protein sequence ID" value="GCB63017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NQA3"/>
    <dbReference type="OMA" id="FYDTDRA"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016256">
        <property type="term" value="P:N-glycan processing to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21599">
        <property type="entry name" value="RRM1_GNPTAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21600">
        <property type="entry name" value="RRM2_GNPTAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.320:FF:000002">
        <property type="entry name" value="N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041536">
        <property type="entry name" value="GNPTAB_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18440">
        <property type="entry name" value="GlcNAc-1_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1238"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="24">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DMAP1-binding" evidence="25">
        <location>
            <begin position="702"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="1033"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB63017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1284" mass="146706" checksum="0D71A6141178BA5E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRW0</accession>
    <name>A0A401NRW0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001319">
        <property type="protein sequence ID" value="GCB63582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRW0"/>
    <dbReference type="STRING" id="75743.A0A401NRW0"/>
    <dbReference type="OMA" id="YYICISC"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="227" mass="26362" checksum="F333A12B3B4E6B23" modified="2019-05-08" version="1" fragment="single">WRSEQRSGMRWCGAVPLAWLAVQLGLSGAIYFHIGETEKKCFIEEIPDETMVIGNYRTQLWDKQSESFLPSTPGLGMHVEVRDPDTKVILSRQYGSEGRFTFTSHTPGEHQICLHSNSTKMSLFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRVRQLLDQVEQIQKEQNYQRFREERFRQTSESTNQRVLWWSIAQTIILILTGIWQMKHLKSFFEAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRW2</accession>
    <name>A0A401NRW2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006669">
        <property type="protein sequence ID" value="GCB63564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRW2"/>
    <dbReference type="STRING" id="75743.A0A401NRW2"/>
    <dbReference type="OMA" id="MIMSKFT"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF8">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="208" mass="22133" checksum="3B3CCFC22065A163" modified="2019-05-08" version="1" fragment="single">EGAGETDGETDAETDAETDEETEAETEAEMDAETDAETDAETDEETEAESNAETDSETEAETDSETDAETESETDAEIDAEMDAGMDAETDAETDAEIDAEMDAGTDAETDAETDAEIDAEMDAGTDAETDAEIDAETDAETDAETDAETDAETDSETDAEMNPETGAEMNPETDAEVDAETDAKMDGEKDREKARYKDGEKVEGDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRX1</accession>
    <name>A0A401NRX1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0011647</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005362">
        <property type="protein sequence ID" value="GCB63592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRX1"/>
    <dbReference type="STRING" id="75743.A0A401NRX1"/>
    <dbReference type="OMA" id="FDEHFLD"/>
    <dbReference type="OrthoDB" id="8961010at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF1">
        <property type="entry name" value="DESMOGLEIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="118"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="279"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB63592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="994" mass="106998" checksum="F0DCF169E2AE1EAE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSN1</accession>
    <name>A0A401NSN1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000037">
        <property type="protein sequence ID" value="GCB63901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSN1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB63901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9442" checksum="761B3EED59D1CE99" modified="2019-05-08" version="1">MPLNVRPRLSSLHAEPCEQHRKQEGRELHVYYCGYCLTDNRIAYSKRELQETTDKKEIGLIIKLLEEVTRNPIASGKCWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTM8</accession>
    <name>A0A401NTM8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001357">
        <property type="protein sequence ID" value="GCB64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTM8"/>
    <dbReference type="OMA" id="RCRRLFM"/>
    <dbReference type="OrthoDB" id="10007210at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037693">
        <property type="entry name" value="CCDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14817">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14817:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62834" checksum="916493F20E9B45EA" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUH4</accession>
    <name>A0A401NUH4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001375">
        <property type="protein sequence ID" value="GCB64507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUH4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10285" checksum="EF1D9DEEA67E878F" modified="2019-05-08" version="1">MKGNCPELENELIKSKKGFEASEDNNRNAVFKLQKLHTEIGELHQEIEQLNIQKAELQVVMDNLRDTKEQHVSAKNNTLKQQDEQLKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW31</accession>
    <name>A0A401NW31_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0014846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008127">
        <property type="protein sequence ID" value="GCB65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW31"/>
    <dbReference type="STRING" id="75743.A0A401NW31"/>
    <dbReference type="OMA" id="WCSGSGW"/>
    <dbReference type="OrthoDB" id="10619164at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45134:SF5">
        <property type="entry name" value="OS08G0543275 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="467" mass="46021" checksum="44EF5264A91E522C" modified="2019-05-08" version="1" fragment="single">MCSGTGANALMCSGTGTKARMCSGTGTNARMCIGTGTNARMCSGTSTKARMCSGTSTNARMCSGTGTKARMCSGTGTKARMCSGTGTNARKCSGTGTNARMCSGTGTKARMCSGTGTKARMCSGTGTNARMRSGTGTKACMCSGTGTKARMCTGTGTNVLMCSGTGTKARMCSGTGTNARMCSGTGNNAHMCSGTGTKARKCSGTGTNARMCSGTGTKAHMCSGTSTKAHMCSGTGTNARMCSGTGTNARMCSGTGTKARMCSGTGTNARMCSGTSTKARMCSGTGTNARMCSGTGTKARKCSGTGTNARMCSGTGTNAHMCSGTGTKARMCSGTGTKARMCSGTGTDARKCSGTGTKARMCSGTGTKACMCSGTGTKARMCSSTGTNARMRSGTGTKACMCSGTGTKACKCSGTGTNARKCSGTGTNARMCSGTNARMCSGTSTKAHMCSGTGTYARMCSGTGTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWD9</accession>
    <name>A0A401NWD9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001421">
        <property type="protein sequence ID" value="GCB65195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWD9"/>
    <dbReference type="STRING" id="75743.A0A401NWD9"/>
    <dbReference type="OrthoDB" id="9934029at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8828" checksum="7E41EF330BC929A5" modified="2019-05-08" version="1">MLDWKDCEKVVKKNSISGQRFLSMSENDIQRFPTLRVPQIHQLCQEINKRDGKRIFFQKRHQNQIIQESTGKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYA7</accession>
    <name>A0A401NYA7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006932">
        <property type="protein sequence ID" value="GCB65853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYA7"/>
    <dbReference type="STRING" id="75743.A0A401NYA7"/>
    <dbReference type="OrthoDB" id="9935710at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004687">
        <property type="entry name" value="LAPTM4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF16">
        <property type="entry name" value="CARTILAGE MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03821">
        <property type="entry name" value="Mtp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="254"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="360" mass="40498" checksum="158349FAE9F289B8" modified="2019-05-08" version="1" fragment="single">MVRFVSNMYHGSHRCLFCHVRTGTIILTASYTIVWTVMAGFELVRLFRPDSKVDVSMVGIHLQGVFHGVETFTSLIFDILMSTISGLGVYGVIKYFPHFLTPFVCYLVGDIIIYCIEVLGIYVELPQYVHAKHYVQNVFFFPEREVVIETGSTKTIIMYTVLFLCVLAFKCFFIYSTWNCYKFIKELEQESSLVDTLLNLRSRDKPPPEDKPKTQYGLLLFTLILVQVNGVPKVKPPKPGPQVPTGLCKTKPTDLVFIIDSSRSVRPSEFEQVKVFVSQVIESLDINPNATQVGVVNYASTVKNEFTLNAHRNKASVLRAVSQIQPLSSGTMTGLAIQFAKNIAFRESHGARIKTNAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYA8</accession>
    <name>A0A401NYA8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006933">
        <property type="protein sequence ID" value="GCB65861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYA8"/>
    <dbReference type="STRING" id="75743.A0A401NYA8"/>
    <dbReference type="OMA" id="HSWENIR"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001928">
        <property type="entry name" value="V-Ha-ras Harvey rat sarcoma viral oncogene-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13092" checksum="FCA59C4B1C59EAA9" modified="2019-05-08" version="1">MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREWRMPFTPWSARSVNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYF0</accession>
    <name>A0A401NYF0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase RNF123/RKP TPR repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008222">
        <property type="protein sequence ID" value="GCB65884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYF0"/>
    <dbReference type="STRING" id="75743.A0A401NYF0"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057987">
        <property type="entry name" value="TPR_RNF123/RKP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25576">
        <property type="entry name" value="TPR_RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase RNF123/RKP TPR repeat" evidence="4">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="19059" checksum="F65969FDDAECDB1E" modified="2019-05-08" version="1" fragment="single">PCPSTLLQQHMADLLRSDSEMAASFLNSVLNQLNWAFSEFIGMIQEIQQAAERPERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLNWSRPSAELLLRRLAQLINQVLNRVTAEKNLFDRVVNLRLPGLESVDHYPILVAVTGILVRILVDSDVQGWDQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZI7</accession>
    <name>A0A401NZI7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004275">
        <property type="protein sequence ID" value="GCB66298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZI7"/>
    <dbReference type="OMA" id="WSTLWDP"/>
    <dbReference type="OrthoDB" id="9943895at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="281" mass="31297" checksum="5528BD845B07B096" modified="2019-05-08" version="1">MVEPWNRHEQRSPEQRRIVGTGEVLEVSQNGKVLNSCARCECLNIAKSCDVSAGAKGHPVNAKGEQVYSLLQVRQVEAITATREAMKGSDEMKEEADSGGCEEVELQLTNEKSGDFAIMKDFAKVQAQICRTDVNTAVLSEPIILICQIPVDFSGSISSGSDADSLSTGSNSPIFYNDQDLSLWSTLWDPALMSEPLKSLAVDPKSVHEMSNKTANFQFKLINRLETWSAEVKTKFRSQLHQLMQRVKPKVRLPERKKLEEDSDLVEEHKQEDGFSDIPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P043</accession>
    <name>A0A401P043_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein-signaling modulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0000600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000111">
        <property type="protein sequence ID" value="GCB66477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P043"/>
    <dbReference type="STRING" id="75743.A0A401P043"/>
    <dbReference type="OMA" id="CAPPNSI"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF2">
        <property type="entry name" value="G-PROTEIN-SIGNALING MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB66477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32780" checksum="6C461E096CC98A16" modified="2019-05-08" version="1">MSSPPQDCHSAPHPADYEAQGARPRIVVHCSMENMDVVKFPPEKDQNGDVAGEHHTTELKNTAKLPWAGQLRIKKYQGNTASSEDKQGPNASLPLVDASDVRVQVAPMKVNRDPSDEDCFFDLLSRFQSNRMDDQRCTFEERQNGTTGSASTPVSPLQDRISQATLIASPQTEEFFDLIASSQSRRLDDQRANVGNLPGLRITHNNSQVVMGHLRPDGDPQEPGDEFFNMLMKCQSSRIDDQRCAPPSPGPRGPTVPDEDFFSLIQRVQAKRMDEQRVDLPSSREGLEQNRPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P063</accession>
    <name>A0A401P063_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-crystallin A4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Beta-A4 crystallin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007004">
        <property type="protein sequence ID" value="GCB66490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P063"/>
    <dbReference type="STRING" id="75743.A0A401P063"/>
    <dbReference type="OMA" id="FIMECDR"/>
    <dbReference type="OrthoDB" id="8688215at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000004">
        <property type="entry name" value="Crystallin beta A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF19">
        <property type="entry name" value="BETA-CRYSTALLIN A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="8">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="8">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB66490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="18225" checksum="69AC0BCF882C7A20" modified="2019-05-08" version="1">MSMAGGTQATGSWVGYEHAAYQGQQFVLERGEYPRWESWSGSNSYHIERLTSFRPIACANHRECRLSMFERENFLGRKGELSDDYPSLQAMGWCNNEVGSFRIHSGAWVCYQYPGYRGYQFIMECDRHCGEYKHWREWGSHAQTFQIQSIRRIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P158</accession>
    <name>A0A401P158_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3</fullName>
            <ecNumber evidence="24">1.14.11.33</ecNumber>
            <ecNumber evidence="23">1.14.11.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Alkylated DNA repair protein alkB homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">scyTo_0010153</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + 2-oxoglutarate + O2 + H2O = a 2'-deoxycytidine in single-stranded DNA + glyoxal + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:70471"/>
            <dbReference type="Rhea" id="RHEA-COMP:12846"/>
            <dbReference type="Rhea" id="RHEA-COMP:17906"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:34779"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:189585"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:70472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:30299"/>
            <dbReference type="Rhea" id="RHEA-COMP:12192"/>
            <dbReference type="Rhea" id="RHEA-COMP:12193"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:32875"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="1.14.11.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:30300"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + 2-oxoglutarate + O2 = a 2'-deoxyadenosine in single-stranded DNA + formaldehyde + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70447"/>
            <dbReference type="Rhea" id="RHEA-COMP:17895"/>
            <dbReference type="Rhea" id="RHEA-COMP:17896"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:139096"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N(1)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12415"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="1.14.11.54"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + 2-oxoglutarate + O2 = a 2'-deoxycytidine in single-stranded DNA + formaldehyde + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70435"/>
            <dbReference type="Rhea" id="RHEA-COMP:12846"/>
            <dbReference type="Rhea" id="RHEA-COMP:17894"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:139075"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:70436"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with the ASCC complex composed of ASCC1, ASCC2 and ASCC3. Interacts directly with ASCC3, and is thereby recruited to the ASCC complex. Interacts with OTUD4; the interaction is direct. Interacts with USP7 and USP9X.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.33" evidence="24"/>
    <dbReference type="EC" id="1.14.11.54" evidence="23"/>
    <dbReference type="EMBL" id="BFAA01004322">
        <property type="protein sequence ID" value="GCB66833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P158"/>
    <dbReference type="STRING" id="75743.A0A401P158"/>
    <dbReference type="OMA" id="FEFHQPT"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990930">
        <property type="term" value="F:mRNA N1-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000003">
        <property type="entry name" value="alpha-ketoglutarate-dependent dioxygenase alkB homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0558">Oxidation</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="28">
        <location>
            <begin position="170"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00064884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00066588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00071421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="GCB66833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="282" mass="33079" checksum="E9A235609A78FF6E" modified="2019-05-08" version="1">MADKRQRARVQGAWAGSSNTAGSSFQVNRRSSENVAGAHRPPKEQAAPDRRFVYQNPTEVQRKIPEERIIDKEGFYEISSSSTGVSRLHLKPAFVDLKEADWMFEQLHMEIPWQQKSNIREDRSYQEPRLTAWYGDLPYTYSRSAMKANPHWHPLLTMLKDHIEEVTGYTFNSLLCNLYRNGKDSIDWHSDDEPSLGRKPVIASLSFGETRNFEMRKKPPPEEKGDYTYAERIRIPLNHGCLLVMEGETQKDWQHRVPKEYHDRNPRINLTFRTIYPETRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1Y3</accession>
    <name>A0A401P1Y3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008384">
        <property type="protein sequence ID" value="GCB67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1Y3"/>
    <dbReference type="STRING" id="75743.A0A401P1Y3"/>
    <dbReference type="OMA" id="GKHFIEY"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000562">
        <property type="term" value="P:negative regulation of CD4-positive, alpha-beta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032689">
        <property type="term" value="P:negative regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000078">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000124">
        <property type="entry name" value="Galectin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF80">
        <property type="entry name" value="GALECTIN-9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="251"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="381" mass="41681" checksum="4BC7E0BEB61B42B5" modified="2019-05-08" version="1">MDFYSNPLPVINPSIPYTGPIPGGLQDGKMIMIKGRVPPHTNRFHVNLHCGQMAHHCDVAFHFNPRYESANYVVCNSFENRSWCSEERKHEMPIQRGETFQLLILVQSDCYKVAVNDKHFLEFKHRIPFSRVDTITIEGQVEVVSLSFINSNIQPAAPAGNANNFNPGFPGFPAPGNACSAGSMFGPPPPANPFQAGSMSAPPAYANPAGSMSAPPAFANPAGSMFPPPAFANPAGSMFAPLALVNLQVPYKALIPGGLFVSRSVVIQGTVKPNCDNFSINLKPSDSLDIALHISPRFRTETAVIRNSRQQNSWGTEERTLAENLFSPGQSFEVTILCEASSFRVSVNGRHAFDFNHRFQPIQQINELQIDGDVTLSNVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2Q3</accession>
    <name>A0A401P2Q3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0005127</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:23361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:56561"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01001569">
        <property type="protein sequence ID" value="GCB67418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2Q3"/>
    <dbReference type="STRING" id="75743.A0A401P2Q3"/>
    <dbReference type="OMA" id="YERMIYL"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000025">
        <property type="entry name" value="Glycogenin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB67418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="331" mass="37271" checksum="C14BFD329EF22D8F" modified="2019-05-08" version="1">MSDQAFVTLATNDLYGKGALVLGTSLRKHKTTRQLVVLVSPQVSNNMRAVLGRVFDEIILVNVLDSKDSAHLAMIKRPELGVTFTKLHCWALTHYSKCIFMDADTLVLCNIDELFQREELSAAPDPGWPDCFNSGVFVYRPSIETYNELLQFSTTKGSFDGGDQGLLNSFFSNWATADINKHLPFIYNLSSVAIYSYLPAFKQYGADAKVVHFLGNVKPWNYTYDPTTRCVMRDSQDHSSVVHPEFLNMWWDAFTTSVSPLLIEHGISKEASPGKQEEEKLSEAVSQLSFTPPPPVASSEERRKKWEQGQADYMGVDSFENIQKKLDAYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2U6</accession>
    <name>A0A401P2U6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Regulator of G-protein signaling 7-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0015117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008415">
        <property type="protein sequence ID" value="GCB67441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2U6"/>
    <dbReference type="STRING" id="75743.A0A401P2U6"/>
    <dbReference type="OMA" id="WHVSADI"/>
    <dbReference type="OrthoDB" id="9876293at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026512">
        <property type="entry name" value="RGS7BP/RGS9BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21029">
        <property type="entry name" value="R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19232" checksum="F6818E00D84BB7D2" modified="2019-05-08" version="1">MLNIAREHLIAKYGNFKLFNAEDGEIHPEICRLYIQLQCCLEMYTTEMLKSVCLLGSLQLHRKGSESLVAPKVIDSKQEESSQAPILEDPPTSPLQDLQPYSWHVSADIENTERDIREMKNLLSKLRETMPLPLKNQDDSSLLNLTPYPLVRRRKRRFFGLCCLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P338</accession>
    <name>A0A401P338_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004388">
        <property type="protein sequence ID" value="GCB67565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P338"/>
    <dbReference type="STRING" id="75743.A0A401P338"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="3"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="14163" checksum="5237F172A452DC62" modified="2019-05-08" version="1" fragment="single">VWFQNRRAKHRKQERAIQKSIPPTVISACSGLIPGVCPVSTSTRPYHYSHAINHIPRFSSMATSAYGSPAAVSQFTCTSTHAHLASAPPPRQHDDWYTPLRSINTPTAGLPSSMLSLPPVSGLDPPAHWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3A8</accession>
    <name>A0A401P3A8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0015133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008433">
        <property type="protein sequence ID" value="GCB67593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3A8"/>
    <dbReference type="STRING" id="75743.A0A401P3A8"/>
    <dbReference type="OMA" id="GFHQEGW"/>
    <dbReference type="OrthoDB" id="8936120at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF193">
        <property type="entry name" value="LOC571647 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="208"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB67593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="365" mass="41506" checksum="6225FC3AD066F9A0" modified="2019-05-08" version="1">MICSLFVSHSVGSIFWDFVFMLFLCVSVSHSLRYFYTAMSPIPGLPEIVAVGYVDDIPIDYYDSDLRKLIPRQQWIQECQSLEYWDEQTQILRSSEHVGQTNIQTALNRTNQSGGIHTVQVMHGCELRDDGLTSGFHQEGWDGQDYISFDKDHMVWVTPVAWGLITKNKWDENKARNQQRKAYLEGTCIEWLKKYLEQGKQHLESISPQVFLFVDKVSDTNLAQITCLVTGFYPRDIEVILLRNGEDFMDAYSTGILPNHDGTYQLRRWAQINPEDGATYSCQYEQSEKEVETRDWDGMFRVIPGSRRGINSRLDVGIVVAVVALITVVIGAIVWKRTGVERKSAYRPANCTAGGESSSNSSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3D1</accession>
    <name>A0A401P3D1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nucleoside-triphosphate phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0005167</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01001582">
        <property type="protein sequence ID" value="GCB67632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3D1"/>
    <dbReference type="STRING" id="75743.A0A401P3D1"/>
    <dbReference type="OMA" id="QYDVMEE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24045">
        <property type="entry name" value="ASKHA_NBD_NTPDase4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000057">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000003">
        <property type="entry name" value="ectonucleoside triphosphate diphosphohydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF37">
        <property type="entry name" value="ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB67632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="603" mass="69215" checksum="05AC2E9A131B2AC1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3I7</accession>
    <name>A0A401P3I7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate kinase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + AMP = GDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:29863"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004401">
        <property type="protein sequence ID" value="GCB67694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3I7"/>
    <dbReference type="STRING" id="75743.A0A401P3I7"/>
    <dbReference type="OMA" id="HEEFXIT"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB67694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="202" mass="22413" checksum="C1CF8F4315254F91" modified="2019-05-08" version="1" fragment="single">AQRLAGYYNVCHLATGDMLRAMVATGSELGQKLKKTMDAGKLVSDEMVVELIDKNLDTPACKNGFLLDGFPRTVNQAQIFDKQLEKRSEKLDSVLELKIEDNLLITRICGRLIHQASGRSYHELYNPPKTPMEDDVTGEPLIKRSDDNEETLKSRLAAYHTQTKPLISYYQKKGLHTAVDATQPPDVVYSTILAAFSGAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3W3</accession>
    <name>A0A401P3W3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0000771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000158">
        <property type="protein sequence ID" value="GCB67776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3W3"/>
    <dbReference type="STRING" id="75743.A0A401P3W3"/>
    <dbReference type="OMA" id="QVSFWIV"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="50"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="253" mass="28820" checksum="CD30157DC0E9366B" modified="2019-05-08" version="1">MYKRNGLMANLRVTSATPEGSSSSDSLDGPYSDYAMKSYDAVVFDVLKVTPEEFASQITLMDVPVFKAIQPEELTSCGWNKKDKHILAPNIVAFTRRFNQVSFWIVREILTAQTLKIRAEILSHFIKLAKKLLELNNLHSLMAVVSGLQSAPIFRLSKTWALVSRKDKATFEKLDYLVTKEDNYKRMREFISSLRMVPCIPYLAKSVSYLYYHLTLYLLSDRQVSARKLMMIRDSVLLQLSQICSGISDAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P410</accession>
    <name>A0A401P410_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0000783</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ZAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000161">
        <property type="protein sequence ID" value="GCB67847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P410"/>
    <dbReference type="STRING" id="75743.A0A401P410"/>
    <dbReference type="OMA" id="QICETCK"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026775">
        <property type="entry name" value="Zar1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31054:SF6">
        <property type="entry name" value="ZYGOTE ARREST PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31054">
        <property type="entry name" value="ZYGOTE ARREST PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="3CxxC-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB67847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="410" mass="45415" checksum="178BAAEBA03C4A36" modified="2019-05-08" version="1">MVALIILFILTGILLGPELLATIPASVYMVAVLMPLAGYVAGYGLGALFKLPPNCKRTVSLQTGCQNVQLCTAILKLAFPPQVIGGIYMFPLLYALFQVAEAALFVLAYKIYTRGELDTEPPGQGDDTDISYKKLKEEELTDSAYGAVNPNLTPRLRKANTKDVGVQVNPRTDASVQCSLGPRTLVMMTMRRRGAVKRRPLVQGSQASMPKNVRFRRTMAIYSPIVSPNLNTFLSRGEARDAGQADRKEPAEKPQQAEQVAAGEEQVAAERTPEQVEECEEQGTAIADGPTDPPEQPEDPATDENEQDSGNVIKTTPREKRLRFQFLEQKYGYFHCKDCNARWESAYVWCVQGTNKVYFKQFCRTCEKAYNPYRVEDITCQKATAVNGISNMKAGGFQSFEYVECCVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4T0</accession>
    <name>A0A401P4T0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007183">
        <property type="protein sequence ID" value="GCB68100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4T0"/>
    <dbReference type="STRING" id="75743.A0A401P4T0"/>
    <dbReference type="OMA" id="YYICLEN"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19901">
        <property type="entry name" value="DSRM_RBM46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12496">
        <property type="entry name" value="RRM3_RBM46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000168">
        <property type="entry name" value="RNA binding motif protein 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044462">
        <property type="entry name" value="RBM46_DSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047837">
        <property type="entry name" value="RBM46_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14709">
        <property type="entry name" value="DND1_DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB68100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="334" mass="37612" checksum="B3195438153955F9" modified="2019-05-08" version="1">MVGTFQLWGHTIQVDWADPEKEVDEETMQKVKVLYVRNLMISTTEETIKMEFNKIKPGAVERVKKLRDYAFVHFFDRDDAVTAMNIMNGKCIDGASIEVTLAKPVNKDGSWKYTQGSQVNLNCENQRLTFTNKEDGVPKTPGRSPSLPARLNGHHSPCSPELERCTYPLFPGIKLTPLSIYSLKPSHFQSSVTHLEYYCNKNNWAPPEYYLYSTTSQDGKQLLVYKVVIPSLANSSQGTLSHFMPDKLCTMLEDAKELAAQYALTHLDYSLRRTNSVSSLSQVGTPLPTSASSLLQYTSRPYSYPSYPLSTTLPLGNNNHIGQRLYVSSHGSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6A6</accession>
    <name>A0A401P6A6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear FMR1 interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001648">
        <property type="protein sequence ID" value="GCB68610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6A6"/>
    <dbReference type="STRING" id="75743.A0A401P6A6"/>
    <dbReference type="OMA" id="HWLETWQ"/>
    <dbReference type="OrthoDB" id="8849279at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
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            <end position="187"/>
        </location>
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        <location>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="EMBL" id="GCB68610.1"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="70688" checksum="F6468893F8BCF4D7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6C1</accession>
    <name>A0A401P6C1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium homeostasis endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">scyTo_0012309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="OrthoDB" id="21470at2759"/>
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    </dbReference>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Calcium homeostasis endoplasmic reticulum protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7819"/>
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    </dbReference>
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        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Surp module (SWAP domain)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="90"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="814"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="462"/>
        </location>
    </feature>
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        <location>
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            <end position="480"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="787"/>
        </location>
    </feature>
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        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB68658.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="102618" checksum="C7FD9B7D6FE77D7E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8P1</accession>
    <name>A0A401P8P1_SCYTO</name>
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            <fullName evidence="11">E3 ubiquitin-protein ligase RNF166</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="13">RING finger protein 166</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RING-type E3 ubiquitin transferase RNF166</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0005482</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16549">
        <property type="entry name" value="RING-HC_RNF166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051438">
        <property type="entry name" value="RNF_E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034734">
        <property type="entry name" value="ZF_C2HC_RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18574">
        <property type="entry name" value="zf_C2HC_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51803">
        <property type="entry name" value="ZF_C2HC_RNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC RNF-type" evidence="17">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB69472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="234" mass="26021" checksum="611906AF71C04243" modified="2019-05-08" version="1">MAMFRSFVSGGQAKQAPVAPGENLADSYSCPICLEVYHKPVSIASCGHAFCGECLQPCLQVVSPLCPLCRMPFDPKKVEKASNVEKQLSSYKAPCRGCNKKVTLVKMRTHISSCNKVQEQMDNCPKFVPVVPTMQPIPSNIPNRSTFVCPYCGARNLDQQELVKHCMENHRSDPNKVVCPICVAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYNIDEDAALHAAIALSLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9I2</accession>
    <name>A0A401P9I2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0001119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000239">
        <property type="protein sequence ID" value="GCB69762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9I2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019201839" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB69762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7441" checksum="6842F32E262CB362" modified="2019-05-08" version="1">MDHLRCRIPDVPDPVPKAPIRNRLTPLLPPLLLLPLLSPVVLAIESPHSEVENTELPDELPLSSYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAG4</accession>
    <name>A0A401PAG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MCM10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0010705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004670">
        <property type="protein sequence ID" value="GCB70135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAG4"/>
    <dbReference type="STRING" id="75743.A0A401PAG4"/>
    <dbReference type="OMA" id="YKMPCKA"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000167">
        <property type="entry name" value="Minichromosome maintenance 10 replication initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor Mcm10 C-terminal" evidence="13">
        <location>
            <begin position="493"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="66"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB70135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="845" mass="93632" checksum="A5BEA57DDA857105" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB45</accession>
    <name>A0A401PB45_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Filensin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beaded filament structural protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0001250</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000274">
        <property type="protein sequence ID" value="GCB70347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB45"/>
    <dbReference type="STRING" id="75743.A0A401PB45"/>
    <dbReference type="OMA" id="DEKQGMA"/>
    <dbReference type="OrthoDB" id="9942423at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070307">
        <property type="term" value="P:lens fiber cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042358">
        <property type="entry name" value="BFSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14069">
        <property type="entry name" value="FILENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14069:SF0">
        <property type="entry name" value="FILENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="10" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="IF rod" evidence="17">
        <location>
            <begin position="59"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="220"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="369"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="517"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="112"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB70347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="704" mass="80552" checksum="1404D89D42F57671" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBJ8</accession>
    <name>A0A401PBJ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0010789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004724">
        <property type="protein sequence ID" value="GCB70493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBJ8"/>
    <dbReference type="STRING" id="75743.A0A401PBJ8"/>
    <dbReference type="OMA" id="PRIVEHM"/>
    <dbReference type="OrthoDB" id="9945370at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012290">
        <property type="entry name" value="Fibrinogen_a/b/g_coil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08702">
        <property type="entry name" value="Fib_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01212">
        <property type="entry name" value="Fib_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58010">
        <property type="entry name" value="Fibrinogen coiled-coil and central regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="9">
        <location>
            <begin position="525"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB70493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="767" mass="86093" checksum="CAEEE6821CBF114A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBS0</accession>
    <name>A0A401PBS0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Synaptosomal-associated protein 25</fullName>
                <shortName evidence="9">SNAP-25</shortName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Synaptosomal-associated protein</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008614</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Synapse</location>
            <location evidence="9">Synaptosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003335">
        <property type="protein sequence ID" value="GCB70564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBS0"/>
    <dbReference type="STRING" id="75743.A0A401PBS0"/>
    <dbReference type="OMA" id="FSMTWKP"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070032">
        <property type="term" value="C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15885">
        <property type="entry name" value="SNARE_SNAP25C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15894">
        <property type="entry name" value="SNARE_SNAP25N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000007">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000009">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000928">
        <property type="entry name" value="SNAP-25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039077">
        <property type="entry name" value="SNAP-25_N_SNARE_chord"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF5">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00835">
        <property type="entry name" value="SNAP-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 9" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB70564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="21698" checksum="DB628B06A488FDF6" modified="2019-05-08" version="1">MQQRADQVADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCACPCNKLKSSDAYKKAWGNNQDGVVASQPARVMDEREQMAISGGFIRRVTNDARENEMDDNLEQVGGIIGNLRHMALDMGNEIDTQNRQVDRIMEKAESNKTRIDEANQRATKMLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCT2</accession>
    <name>A0A401PCT2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000316">
        <property type="protein sequence ID" value="GCB70931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCT2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10589" checksum="7E7C0CBADBB85404" modified="2019-05-08" version="1">MARVFYGKAEYYGKAEYYGKGVLQQREYYSNAEYHSKAAEYYGKAEYHGKEEYYGKAEYHGKEEYYVKAQYYGKAEYYGKAEYYGKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDR5</accession>
    <name>A0A401PDR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008791</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01003433">
        <property type="protein sequence ID" value="GCB71245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDR5"/>
    <dbReference type="STRING" id="75743.A0A401PDR5"/>
    <dbReference type="OMA" id="TINDMPI"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045321">
        <property type="term" value="P:leukocyte activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF163">
        <property type="entry name" value="AT16346P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="22"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB71245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="21492" checksum="1DF5A47A63A6AED2" modified="2019-05-08" version="1">MQTPPAELPLPERDVGVMASGAKIGRPAPDFTAKALMPSGEFQDLTLSSYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAAEFRKINCEVIGASTDSHFSHLAWTKVPRKQGGIGHMEIPLVADMNHSIAKEYDVLKEDEGIAYRGLFVIDDKGILRQITINDLPVGRSVDETLRLVQAFQFTDKHGEGDFFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDV0</accession>
    <name>A0A401PDV0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004852">
        <property type="protein sequence ID" value="GCB71304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDV0"/>
    <dbReference type="STRING" id="75743.A0A401PDV0"/>
    <dbReference type="OMA" id="MEAQARX"/>
    <dbReference type="OrthoDB" id="10000687at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF8">
        <property type="entry name" value="TUMOR PROTEIN D53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB71304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="185" mass="20462" checksum="E945641321E8D0A9" modified="2019-05-08" version="1">MEPVEHDSLETRRFSDLGAEIDLGKLPEGDKEDLGVELAKLEDEISTLRQVLIAKEKHLIEIKQKMGITPLNEIRNNLSKGWHDMQTSVIYKKTQETLNTTGQKASAALNNVSTTLNKKLGEMKNSPTFKSFEERVETTVTSLKCKVGVPTHSSGSFEDVLNSTVNASVQESTSGNHPTEDFGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEJ2</accession>
    <name>A0A401PEJ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0001608</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000366">
        <property type="protein sequence ID" value="GCB71518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEJ2"/>
    <dbReference type="STRING" id="75743.A0A401PEJ2"/>
    <dbReference type="OMA" id="SECNVRE"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000076">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000310">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 20" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10 19 20" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="22">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="399"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="855"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="900"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB71518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="932" mass="103575" checksum="0D37FB2B45D6A6A1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEQ3</accession>
    <name>A0A401PEQ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanyl-transfer RNA synthetases family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001957">
        <property type="protein sequence ID" value="GCB71603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEQ3"/>
    <dbReference type="STRING" id="75743.A0A401PEQ3"/>
    <dbReference type="OMA" id="KYDTTSW"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000003">
        <property type="entry name" value="alanyl-tRNA editing protein Aarsd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000007">
        <property type="entry name" value="alanyl-tRNA editing protein Aarsd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="400" mass="44287" checksum="47ECB6F8ED06F274" modified="2019-05-08" version="1">MFETLVVSCTPAELKITVNGKKETLKGFDVILEDTLLFPEGGGQPDDRGLMNDIPVLRVTRHGPEAIHFVQSTLEPLSIVQLKIDWERRFDHMQQHSGQHLITAIADLMFGFKTTSWELGRQRSFIELDTPSVTGEQVEALELAVNEKIREHIPVNVRVVTVDDPEVEKVRGRGLPDDHAGPVRIIDIVGIDANMCCGTHVSNLSHLQAIKILGTDKGKKNKTYLIFLAGNRVLKYAERSYTVERALTTLLKNGPEEHVEAVDKLQKSVKLLQKNNLSLLRDLALLTANSFKSDPNKGKLLVLHRKDGDNEFMNIIANEVSAEVVLLFLTVGDEKGAGLFLLAGQVDAVEALGSKVSQILDGKGAGKRGRYQGKANKMSKRTEVEALLQQYVSSLDTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEZ5</accession>
    <name>A0A401PEZ5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001968">
        <property type="protein sequence ID" value="GCB71679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEZ5"/>
    <dbReference type="OrthoDB" id="10575466at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="141" mass="16381" checksum="84DCFB2A84E75FE5" modified="2019-05-08" version="1">MLKKLLAVLFFHNCSVLIICVLWQANMKNVEKLVTISQSKSNESCSQKLTKSEKLNNLENDDEPDINTEYTGKDYYCNQKSTDPMLDKLFSFLPTYQMPVQIQLHLLKFCCFVFKLKAIGLIKDNDKFGHCFLRIYDAHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFE1</accession>
    <name>A0A401PFE1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001992">
        <property type="protein sequence ID" value="GCB71853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFE1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="7545" checksum="10A2CCE223B1513A" modified="2019-05-08" version="1">MSGIELTGDRDQEKSAGTQKSAAHTDPKLTTKVLVLRLEPCLPGRYGPWTEACGAKRSGMNRKKAYAGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGS6</accession>
    <name>A0A401PGS6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450 26A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0001914</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-(4S)-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51492"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:134185"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:51493"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000448">
        <property type="protein sequence ID" value="GCB72289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGS6"/>
    <dbReference type="STRING" id="75743.A0A401PGS6"/>
    <dbReference type="OMA" id="KLWNLYC"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034653">
        <property type="term" value="P:retinoic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF101">
        <property type="entry name" value="CYTOCHROME P450 26A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="9 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="10 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB72289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="470" mass="53390" checksum="0EDEBA18242705B8" modified="2019-05-08" version="1">MVLFTLCATFLCTFVLPLALFLAALKLWEVYCLSRKDPSCEKPLPPGSMGLPFLGETLQLVLQRYTFLKMKVRKYGHIYKTHLFGNPTVRIMGAENVKQILLGEHKLVSVQWPASVRTILGAGCLSSLHHTEHKHRKRVILKAFSREALENYIPVMGEEIRAGLRRWLESGSCVLVYPEIKRLMFGIAMRILLGFEPTHTTRQTQQELIEAFEEMIRNLFSLPIDVPFSGLYRVRIKQRRKREGIDPEKFRAVLFCVASELKESATELLFGGHDTTASTATSLVTFLALHPEVLQKVRVELQEQGLLSSDSAENKQITLELLEQLKYTGSVIKETLRLSPPVPGGFRVALKTFVLNGYQIPKGWNVIYSICDTHDVATNFSKKDEFNPDRFMEGCSEKDACRFSYIPFGGGSRSCVGKEFAKILLKIFTMELVRACDWELLNGPPMMKTNPTVYPVDNLPTKFTPFRNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIK0</accession>
    <name>A0A401PIK0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002221">
        <property type="protein sequence ID" value="GCB72931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIK0"/>
    <dbReference type="STRING" id="75743.A0A401PIK0"/>
    <dbReference type="OMA" id="IMTQRYS"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF88">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR L2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9285" checksum="071B91CA9B4537BE" modified="2019-05-08" version="1">MGANRGALGFSRAALPFGLVRRELSCEGYPIDLRCPGSDVIVIESANYGRTDDRICDADLFQMENVQCYLPDAFKIMTQRYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIS2</accession>
    <name>A0A401PIS2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0006574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002238">
        <property type="protein sequence ID" value="GCB73001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIS2"/>
    <dbReference type="STRING" id="75743.A0A401PIS2"/>
    <dbReference type="OMA" id="AMTYNNT"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB73001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="256" mass="29780" checksum="53F32A9FB4E31F15" modified="2019-05-08" version="1" fragment="single">QISQIDTDLKSRAMTYNNTKGNLQNLERKAVGSLLTRTLADIVNKEDFVVDSEYLTTLLAFVPKSNYSNWQKTYESLADMVVPRSTKMIIEDIEGALFTVTLFKKTVDEFKIRARENKFIVREFSYSEEELHAEKEEMTRLSADKKQQYGPLLRWLKVNFSEAYIAWIHIKALRVFVESVLRYGLPVNFQAMLLQPNKKSMKRLRDVLNALFKHLDEVAAASTVDANMDIPGLNVNQQDYYAYVYFKIDIDLFNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKR7</accession>
    <name>A0A401PKR7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="11">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0002769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01000712">
        <property type="protein sequence ID" value="GCB73688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKR7"/>
    <dbReference type="STRING" id="75743.A0A401PKR7"/>
    <dbReference type="OMA" id="WLWDARY"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB73688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="547" mass="62582" checksum="C66912A2FF9F4F0C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PL60</accession>
    <name>A0A401PL60_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000771">
        <property type="protein sequence ID" value="GCB73876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PL60"/>
    <dbReference type="OrthoDB" id="9950234at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="132" mass="15468" checksum="DFC3523DF61636E4" modified="2019-05-08" version="1">MKISEITKRLFVWESNYSKLCKADTKLEADLQNIEQDTELKDERIRELNHTIEALWITADELADRKVDLTIRIGKLQNEIKEKHDLLSKSRKEETVDTQAANMPRRIRRRSQPAPPKQPEQLLDGATFPNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLS8</accession>
    <name>A0A401PLS8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Abl interactor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0003183</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000853">
        <property type="protein sequence ID" value="GCB74096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLS8"/>
    <dbReference type="STRING" id="75743.A0A401PLS8"/>
    <dbReference type="OMA" id="GPLYAQN"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000002">
        <property type="entry name" value="abl interactor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028457">
        <property type="entry name" value="ABI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012849">
        <property type="entry name" value="Abl-interactor_HHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460:SF2">
        <property type="entry name" value="ABL INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460">
        <property type="entry name" value="ABL INTERACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07815">
        <property type="entry name" value="Abi_HHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="412"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="148"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB74096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="51476" checksum="8BBEFAEFB2A8B2F5" modified="2019-05-08" version="1">MAELQMLLEEEIPAGKRALIESYQNLGRVADYCENNYVQAQDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPASVERPVRYIRKPIDYTVLDDVGHGVKHGSNQPARTGTLTRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPVIPNDYMTSPARNVTTNQQSPMRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPAPSPPTLLPASYSVPAGAPSLPPPPPPLPVGSFIAGPGSAPSSQYSTMTRQISRHNSTTSTASSGGFRRNPSVTSQFSVQPHVNGGPLYAQNSIADSPTPPPPPPPDDLPIFDESPPPPPPPPVDYEDEEAAVVQYNDPYADSDPQWAPKIYLEKVVAIYDYSKDKEDELSFMEGSIIYVIKKNDDGWYEGVINGVTGLFPGNYVEPIMHYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PM00</accession>
    <name>A0A401PM00_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Polycystin-1-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">scyTo_0003244</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000872">
        <property type="protein sequence ID" value="GCB74157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PM00"/>
    <dbReference type="OMA" id="EYLMSEG"/>
    <dbReference type="OrthoDB" id="10044145at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000017">
        <property type="entry name" value="Polycystin 1 like 1, transient receptor potential channel interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF4">
        <property type="entry name" value="POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1855"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2071"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2108"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="23">
        <location>
            <begin position="510"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="23">
        <location>
            <begin position="590"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="26">
        <location>
            <begin position="724"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="25">
        <location>
            <begin position="1701"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="24">
        <location>
            <begin position="1910"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1122"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1216"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="1225"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GCB74157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2170" mass="241169" checksum="11CC50116852AF6A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMR9</accession>
    <name>A0A401PMR9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">RIO kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">scyTo_0003517</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Associates with the precursor of the 40S ribosome subunit. Interacts (via its N-terminus) with PRMT5 (via its N-terminus). Interacts with WDR77. Found in a PRMT5 complex composed of PRMT5, WDR77 and RIOK1. Interacts (via its C-terminus) with NCL; this interaction targets NCL for PRTM5 methylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01000966">
        <property type="protein sequence ID" value="GCB74427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMR9"/>
    <dbReference type="STRING" id="75743.A0A401PMR9"/>
    <dbReference type="OMA" id="HPMSLDF"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="27">
        <location>
            <begin position="173"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="508"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="23">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="23">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="28">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="GCB74427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="589" mass="67967" checksum="6C1EDFC24132DDBF" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPS3</accession>
    <name>A0A401PPS3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0020890</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01017561">
        <property type="protein sequence ID" value="GCB75150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPS3"/>
    <dbReference type="STRING" id="75743.A0A401PPS3"/>
    <dbReference type="OMA" id="NPMTYDF"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000081">
        <property type="entry name" value="Chitinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF248">
        <property type="entry name" value="CHITOTRIOSIDASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="41"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="14">
        <location>
            <begin position="442"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB75150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="492" mass="55473" checksum="B06DAF4BD9010C83" modified="2019-05-08" version="1" fragment="single">YKPKLLHTELTSRPMFFLKMGKGLLLTVCFIFLHIPLVSSYKLVCYYTNWAQYRPEGGKFTPTNVAPHLCTHLIYAFASMTNNKLTTFEWNDPAMYVKFNNLKKKNNNLKTLLAIGGWNFGAMRFSSMVATKQTRTTFISSAITFLRKYRFDGLDLDWEYPASRGSPASDKKRFTTLAKELQEAFRAEAQSSGQARLLLTAAVAAGKDTIDAGYEVAEVSKYLDFISVMTYDFHGSWDRVTGHNSPLYRGSGDQGQFIYYNVDYAMNYWKGKGAPAEKLIVGFPTYGRSFTLSSSQTGVGAPVSGPGKPGQFTREPGFWAYYEVCPFLKNATVQYIEDQKVPYAFKGNEWIGYDDQQSFTTKVQWLKRNKFGGAMVWALDLDDFNGTKCNQGVYPLINTLKSLLHVGDSEDLPSSQTTPSPITGPLKPRSNVAIATPQNSGSNWCQGRPHGSYVDPNDRHKYYVCDNDRTFHQDCPANLVFVEDCHCCNWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT44</accession>
    <name>A0A401PT44_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016543">
        <property type="protein sequence ID" value="GCB76300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT44"/>
    <dbReference type="STRING" id="75743.A0A401PT44"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF2">
        <property type="entry name" value="AMP DEAMINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="56" mass="6420" checksum="2D573E6B771427BB" modified="2019-05-08" version="1" fragment="single">EKQNFLGVNYLKDGPEGNDMHRSNVSQIRIAFRFESWNQELKILSQSGKALTLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTP3</accession>
    <name>A0A401PTP3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRC42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008819">
        <property type="protein sequence ID" value="GCB76500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTP3"/>
    <dbReference type="STRING" id="75743.A0A401PTP3"/>
    <dbReference type="OMA" id="FYGKTHR"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039631">
        <property type="entry name" value="LRRC42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31994">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31994:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB76500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="430" mass="47419" checksum="82B67F365F2C4679" modified="2019-05-08" version="1">MVPVVAAGHLGFLPMSSHTSTSPAFEFGPIYVREKGQLHLLNGTSSLTRSAGKSKSLRLFQKGFTVKLCIEDGDKPSTCRTDHIVFTYTKEGSLRYSPKSLFDVVLGFIADNIQHVDSLIGFPEQIAEKLFIAVEARKKFVDPDTSTKALLKFSEAYGSLVLQSLCLRDRCLMVSEKLEEIQSFRGLMCLDLSSCKLGDEHELLTHLTSETLVSLICLYLGDNGLSDSGLRKMTAPIRVKKKGLGNLEVLDLSDNPRISGHGIRYLCCFSKLRALAISGTGVAPDCSSVQTIQSKLSLFPAGEPLEEFKHLCCRTEGWAEQVVYQWERVSVRRHENVGGRTVAQQFYGINKLTNVGSDGLSNGVQIMETFRMQFHRKANNDLCAQSTVASTFGARKRSGGQAEVTGCSSPLAKRKRAEPTLDDWDVLNCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTQ3</accession>
    <name>A0A401PTQ3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0016566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010088">
        <property type="protein sequence ID" value="GCB76510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTQ3"/>
    <dbReference type="STRING" id="75743.A0A401PTQ3"/>
    <dbReference type="OMA" id="DYAFQMM"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056424">
        <property type="entry name" value="Beta-prop_GEMI5_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056420">
        <property type="entry name" value="GEMI5_RBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052640">
        <property type="entry name" value="Gemin-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23775">
        <property type="entry name" value="Beta-prop_RIG_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23777">
        <property type="entry name" value="GEMI5_RBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 second beta-propeller" evidence="6">
        <location>
            <begin position="174"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="5">
        <location>
            <begin position="649"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 RBS" evidence="7">
        <location>
            <begin position="852"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB76510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="950" mass="106065" checksum="7038AE6662CFAAE3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUC8</accession>
    <name>A0A401PUC8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016646">
        <property type="protein sequence ID" value="GCB76749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUC8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="20241" checksum="EAA274263C9873B5" modified="2019-05-08" version="1">MVTGFPLFTEHLPLEHGVNRKKAGLVSNQELEEHMPLDGNVSGERDGPATEQDLEDADIVSGSEEESGQFAESTHRNSRRRLKRKAIRRGGRRQTDPDWDSSAEPESGTARGTKVSSNRRANVNGRGREDASDPEEMELDEDGNPCYYSPRSYQSSVYDSEHEGEVVQGMKHTSRGKQGIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWR7</accession>
    <name>A0A401PWR7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0017620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="BFAA01011605">
        <property type="protein sequence ID" value="GCB77575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWR7"/>
    <dbReference type="STRING" id="75743.A0A401PWR7"/>
    <dbReference type="OMA" id="FPINWNT"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB77575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="472" mass="54616" checksum="DB95ECFEBC1BD851" modified="2019-05-08" version="1">MERLEPLLFSAVVSCGFLVSSVVFALLSREQRNPYMDEVFHVPQAQRYCDGRFSQWDPMITTLPGLYLVSTGIIKPVSWLMGWTGTVVCSTGMLRFINLLFSTGNLYLLYLLLCKIHQKNKATSAFQRIVSALALASFPLLYFFSFLYYTDAGSTFFILFAYLMCLYGSHGIAACLGFCAFMFRQTNIVWIIFCAGSVVAQKLTEAWKTDSLKKKDEKTPPVPSSIAEIMKIVQFLLEYVLSLNNLKALILLIWPYIILVLGFLLFVFLNGGIVVGDRTNHEVSLNFPQLFYFFSFTLVFSVSHLLSPHKVSSFLHSVKKHPLFYTVLVIVSLLLVWKFTYVHKFLLADNRHYTFYIWKNIFQRHELIKYVLVPGYIFAVWAFIETLKSKSLSWNLAFFICLGVATVPQTLLEFRYFIVPYLIYRLNIPMPLGFKILAELALYSLVNVLTIYLFLNKTFQWPDRKEVQRFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX15</accession>
    <name>A0A401PX15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interleukin 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014234">
        <property type="protein sequence ID" value="GCB77662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX15"/>
    <dbReference type="STRING" id="75743.A0A401PX15"/>
    <dbReference type="OMA" id="WVYINSQ"/>
    <dbReference type="OrthoDB" id="9902423at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005157">
        <property type="term" value="F:macrophage colony-stimulating factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045651">
        <property type="term" value="P:positive regulation of macrophage differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045657">
        <property type="term" value="P:positive regulation of monocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.80">
        <property type="entry name" value="Interleukin-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020415">
        <property type="entry name" value="IL-34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038328">
        <property type="entry name" value="IL-34_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28606">
        <property type="entry name" value="INTERLEUKIN-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28606:SF1">
        <property type="entry name" value="INTERLEUKIN-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15036">
        <property type="entry name" value="IL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01938">
        <property type="entry name" value="INTRLEUKIN34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="16248" checksum="810C69A5A4C454D2" modified="2019-05-08" version="1">MKDYFPVNYAVKVHYEDIYRTINVTRMQNRNFTEMNLKLLWVYINSQVLETVLEVLPKRHPSRTYVEDISTLFSYLRMNVEEMVDDIEDDRVEEILSHVSNIDEESKRKSIRPKALFDNCYRVMKQLFQCDWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYQ2</accession>
    <name>A0A401PYQ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018315">
        <property type="protein sequence ID" value="GCB78252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYQ2"/>
    <dbReference type="STRING" id="75743.A0A401PYQ2"/>
    <dbReference type="OMA" id="RLMNANT"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="119" mass="13488" checksum="9D7307688090170D" modified="2019-05-08" version="1">MDSSSSYTWLWADRLMNANTNSWTNPRKHPQTPLLDTSPSSPPSYYEAVCDVKGEVGTDSSIRCSPGALYEAQYYQMTESGLAAPYRRRGGLVDHRDVIKAHEAHKMHSTPQAKRKEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYW5</accession>
    <name>A0A401PYW5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0020652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Displays low GTPase activity and exists predominantly in the GTP-bound form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017014">
        <property type="protein sequence ID" value="GCB78233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYW5"/>
    <dbReference type="STRING" id="75743.A0A401PYW5"/>
    <dbReference type="OMA" id="ICQIKGN"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04140">
        <property type="entry name" value="ARHI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB78233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22561" checksum="50A1F4080B625214" modified="2019-05-08" version="1">MPEQSNDYRVVVFGAAGVGKSSLVLRFVRGTFRETYIPTIEDTYRQVISCDKNICTLQITDTTGSHQFPAMQRLSISKGHAFILVYSVTSKQSVEELQPIYEQICQIKGNIQNIPIMLVGNKRDETQREVEATEGEALATKWMCSFMETSAKLNYNVQELFQELLNLEKRRPVSLQVDGKKSKQQKRKDKLKGKCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0W4</accession>
    <name>A0A401Q0W4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0016904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010573">
        <property type="protein sequence ID" value="GCB79047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0W4"/>
    <dbReference type="STRING" id="75743.A0A401Q0W4"/>
    <dbReference type="OMA" id="NDSNQFR"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB79047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="16512" checksum="2698BEB00A7E406B" modified="2019-05-08" version="1">MSKNTSTDKFRRVNVDDYDENNYVDEDEGGENQIGPDEAEVDASIRQGNLNAALQAALKNPPINTKNQAVKDRAEATVVKVLTSFKSNDIEKAVQSLDKNSIDLLMKYIYKGFEKPSENSSAILLQWHEKVLAAGGVGSVVRVLTARKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1C4</accession>
    <name>A0A401Q1C4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zyxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0019491</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zyxin/ajuba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014576">
        <property type="protein sequence ID" value="GCB79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1C4"/>
    <dbReference type="STRING" id="75743.A0A401Q1C4"/>
    <dbReference type="OMA" id="YAPKCSV"/>
    <dbReference type="OrthoDB" id="9950386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000027">
        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000057">
        <property type="entry name" value="Zyxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24212:SF1">
        <property type="entry name" value="ZYXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24212">
        <property type="entry name" value="ZYXIN/TRIP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="387"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="447"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="49"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="574" mass="62214" checksum="253B96245873D577" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1C6</accession>
    <name>A0A401Q1C6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017244">
        <property type="protein sequence ID" value="GCB79158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1C6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="9293" checksum="8717777FFD5131C9" modified="2019-05-08" version="1" fragment="single">KSPRKKDREFEAHFYVSCFKRTLMKKLEKSWQQRINGEQADISFFFGLQQSFEMFFNSQVSRKTTKLNKFLHYICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q404</accession>
    <name>A0A401Q404_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010808">
        <property type="protein sequence ID" value="GCB80105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q404"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="10631" checksum="60888B253297803E" modified="2019-05-08" version="1">MHCRIGCSKVGLPQVALPGESGERPAVRPDTAGRSRVSAAVAGEAVAEQELQYGVKFEAKQSADGEGQKQKWLRIAWCCPSYCGAPKLQHIVFQRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q710</accession>
    <name>A0A401Q710_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0021790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020029">
        <property type="protein sequence ID" value="GCB81169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q710"/>
    <dbReference type="STRING" id="75743.A0A401Q710"/>
    <dbReference type="OMA" id="SAQHTKC"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000732">
        <property type="entry name" value="GD11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="78"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="135" mass="15358" checksum="A7F80909131A32CA" modified="2019-05-08" version="1" fragment="single">RRLEQNGIKSVPPGTFTPYKKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKINELPKGVFDGLYALQLLHLAQNPFICDCHLKWLADYLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7F6</accession>
    <name>A0A401Q7F6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022722">
        <property type="protein sequence ID" value="GCB81293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7F6"/>
    <dbReference type="STRING" id="75743.A0A401Q7F6"/>
    <dbReference type="OMA" id="EVAHARC"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="211" mass="24093" checksum="6E60A9972BCE17A6" modified="2019-05-08" version="1" fragment="single">MVKQVTWHGKGDYLATVIPDNGNAQVLIHQLSKRRSQNPFRKNKGMVQCVLFHPIRPYFFVATQRYVRVYNLLKQELTKKLMANCKWVSSMAIHPGGDNVICGSYDSRLAWFDLDLSTKPYKMLRHHKKAIRGVAFHKHYPLFASASDDGTVIVCHGMVYSDLLQNPLIVPVKLLRGHEISRDLGVLDVTFHPTQPWLFSSGADCTIRLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7J9</accession>
    <name>A0A401Q7J9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 2-epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022757">
        <property type="protein sequence ID" value="GCB81348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7J9"/>
    <dbReference type="STRING" id="75743.A0A401Q7J9"/>
    <dbReference type="OMA" id="VTYHPVT"/>
    <dbReference type="OrthoDB" id="2968753at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03786">
        <property type="entry name" value="GTB_UDP-GlcNAc_2-Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000013">
        <property type="entry name" value="Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000015">
        <property type="entry name" value="Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020004">
        <property type="entry name" value="UDP-GlcNAc_Epase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03568">
        <property type="entry name" value="NeuC_NnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174:SF3">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-N-acetylglucosamine 2-epimerase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="332" mass="37017" checksum="5D03D6D23AB2FC85" modified="2019-05-08" version="1" fragment="single">EIMEKNKNRKKLRICVATCNRADYSKLAPIMFGIKEQPDVFDLKVVVLGSHLIDDYGNTYRMIEQDDFDISTSLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDLMIVHGDRFDALAVATSAALMNIRILHMEGGEVSGTIDDSIRHAITKLAHYHVCCTRGAEQHLIAMCEDHNRILLSGCPSYDKLLTAGSKDYLSILQTWLSKDVKSREYIVALQHPVTTNIKHSVKMFELTLDALITFSKRTLILFPNIDAGSKEMVRVMRKKGIEQNPNFRAVKHIPFEQFIQMVAHAGLMIGNSSCGVREAGAFGTPVINLGTRQTGRETGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7Q2</accession>
    <name>A0A401Q7Q2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021487">
        <property type="protein sequence ID" value="GCB81400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7Q2"/>
    <dbReference type="STRING" id="75743.A0A401Q7Q2"/>
    <dbReference type="OMA" id="MVRNWTT"/>
    <dbReference type="OrthoDB" id="9932958at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="11023" checksum="885CFE9A01AB758B" modified="2019-05-08" version="1" fragment="single">AHSLCEDTSSELQGVTSMETKGQPESRRSSSTGRGALARLTQFILMVRNWTTQQMHNEDQRPDSFLERFRGPEMKDVSSRESNTQSALGNLEHPGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8N3</accession>
    <name>A0A401Q8N3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020357">
        <property type="protein sequence ID" value="GCB81721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8N3"/>
    <dbReference type="STRING" id="75743.A0A401Q8N3"/>
    <dbReference type="OMA" id="GHQARLE"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF10">
        <property type="entry name" value="MYOSIN VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0518">Myosin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="15412" checksum="99FF263EAE0B21DD" modified="2019-05-08" version="1" fragment="single">MRETIRIRKSGYPIRFAFLDFVQQYKLVLRSALWQIKQENAHLCCKQIAESVIGTNGDWKIGRTKIFLKENDHLTLELERDRILTAKALMIQKVIRGYKDRKNFLRQRNAACMIQSHWRGSQCRKKYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Y5</accession>
    <name>A0A401Q8Y5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021760">
        <property type="protein sequence ID" value="GCB81842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8Y5"/>
    <dbReference type="STRING" id="75743.A0A401Q8Y5"/>
    <dbReference type="OMA" id="FTRSCES"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="214" mass="24481" checksum="1F80AD91BB0632EF" modified="2019-05-08" version="1">MTKKVQKLQRAALKDPVKCAVSTKYQTVEKLQQYYVFIPSKFKDCYLVSILNELAGNSFIIFCSTCNNTQRTALLLRNLGFTAIPLHGQMNQNKRLGALNKFKAKSRSVLLATDVASRGLDIPHVDVVINFDIPTHSKRIEHLIDKKLPAFPTQEEEVMLLVERVTEAQRFARLELREQGDKRKRPRDEADDDTENSLGIRQKVSGGKMRKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9Y1</accession>
    <name>A0A401Q9Y1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0022624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023269">
        <property type="protein sequence ID" value="GCB82161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9Y1"/>
    <dbReference type="STRING" id="75743.A0A401Q9Y1"/>
    <dbReference type="OMA" id="QIMESRD"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF462">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB82161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="9498" checksum="39759402D6E3A931" modified="2019-05-08" version="1">MPRYCLFGDTVTTASRMESTGRPYRIHVNHTTVKILLSLDEGYKVEPRERTDLMGQGFEQTYWLLGKDGFTKPLPKPPELKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAJ1</accession>
    <name>A0A401QAJ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024726">
        <property type="protein sequence ID" value="GCB82376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAJ1"/>
    <dbReference type="STRING" id="75743.A0A401QAJ1"/>
    <dbReference type="OMA" id="FPTCLIS"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF2">
        <property type="entry name" value="POSTACROSOMAL SHEATH WW DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9237" checksum="CBF9FE9814207ADE" modified="2019-05-08" version="1" fragment="single">FLKECKDVELSFSDMTAKSDFFKGTKKGTLYLTPYRMIFLSKGKDPMQSFMMPFYLVKGCSIEQPVFSANYIKGTIRAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAM7</accession>
    <name>A0A401QAM7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026064">
        <property type="protein sequence ID" value="GCB82435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAM7"/>
    <dbReference type="STRING" id="75743.A0A401QAM7"/>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF6">
        <property type="entry name" value="MUCOLIPIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="13309" checksum="D912BE2419B85E3F" modified="2019-05-08" version="1" fragment="single">GRLIFDIFVILLCVLSFVLCIRSIIRGVVLQHEFGKFIQLKHGKEVSCSTRMEFLNGWYILLIVSDIFTFLGTIMKIGIESKNFASYDVCSILLGTSTLLVWVGVIRYLSFFQKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBH7</accession>
    <name>A0A401QBH7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019740">
        <property type="protein sequence ID" value="GCB82702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBH7"/>
    <dbReference type="STRING" id="75743.A0A401QBH7"/>
    <dbReference type="OMA" id="PETYLMY"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="312" mass="37539" checksum="0154C09E7EF6369B" modified="2019-05-08" version="1">MPTATIQTATIQTATIQTATIQTGSIQTATNQIDTCYPDSYFPDSYYPDSYYPDSYYSDSYYPDRYYPDSYYPDSYYPDSDYRDSYYPDRYYPDSYYADSYYPDSYYPDNRYNPDSSHPDSYYPDNDYPDSFYPVSFYPASYYPDIYCPDNDYPDSYYPDSYYADSFYPESYYAGSYYQESYYPDSYYPGIYYPESYYPDSHYPDSYYPDSYYPDSYYPDSCYPDNDYPDSYYPDSYYPDSYYPDSYYPDSCYPDNDYPDSYFPDSYCPDGYYPDSYYPDSYYPDSYYPDSCSRDSSYTDSFYPDNDYTDCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC75</accession>
    <name>A0A401QC75_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calsequestrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the calsequestrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01035342">
        <property type="protein sequence ID" value="GCB82974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC75"/>
    <dbReference type="OrthoDB" id="10038131at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001393">
        <property type="entry name" value="Calsequestrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01216">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="87" mass="9626" checksum="598F511D8D4E9E13" modified="2019-05-08" version="1" fragment="single">ATLRKLKPDSMYETWEDDIDGMHIVVFAEEDDAGQHREGGGGWVTGLEEFWKGRGKADGWRVPSGTATLWNNPLGVPVVVSEAWIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCC2</accession>
    <name>A0A401QCC2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01036715">
        <property type="protein sequence ID" value="GCB83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCC2"/>
    <dbReference type="STRING" id="75743.A0A401QCC2"/>
    <dbReference type="OrthoDB" id="5818577at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
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    </dbReference>
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    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8306" checksum="6AF481CE7BB41765" modified="2019-05-08" version="1" fragment="single">ECGGHIIGEASGRIFSPGYPAPYDHNLHCTWSVEADPGSTIGKAVHVSYNSQEKRDVQIDNPVEENTEIGLLNRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401QDB2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Cloudy catshark</name>
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        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030893">
        <property type="protein sequence ID" value="GCB83375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDB2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="85" mass="8548" checksum="B0C405F9667FBAEA" modified="2019-05-08" version="1" fragment="single">MINPGIVQKVQSMSPVPAHSPINASHLVQPSGLHPATGQVQGKMLVAVPAPQVTLGAVATTAAGQAHMATPSIPLQNGAQQQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI47</accession>
    <name>A0A401QI47_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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            <taxon>Scyliorhinus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01110768">
        <property type="protein sequence ID" value="GCB85013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI47"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="144" mass="17626" checksum="7ED7AEF1BDEF4EB0" modified="2019-05-08" version="1">MKEGERERSEMKEGERERKETKEGERELNETKEGERGRNETKEGQRERNEMKEGQRERNETKEGQREGNETKEGERERNETKEGETERNKSKEGDRERIETKERERERNEFKECKRERNEVKEGKIERNETMEGERERNEMKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ74</accession>
    <name>A0A401QJ74_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01152001">
        <property type="protein sequence ID" value="GCB85413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="FEFYARS"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="277" mass="24805" checksum="A1A84B383C763AA3" modified="2019-05-08" version="1" fragment="single">MAEGRAAAEGRAAAGGRAAAGGRAAAEGRAAAEGRAAAEGRAAAEGPAAAEGRAAAEGQTAAEGRSAAEGRAAAEGRAAAEGRAAAGGRAAAGGRAAAGGRAAAGGWAAAGGRAAAEGRAAAEGRAAAEGRAAAEGRAAAEGPAAAEGRAAAEGQAAAEGRAAVEGQAAAEGRAAAEGQAAAEGQVAAEGRAAAEGQAAAGVRAAAEGQTAAEGRAAAEGQAAAEGQVAAEGRAAAEGKAAAGGRAAAEGRAAAEGQAAAAGRAAAEGRAAAEGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJA7</accession>
    <name>A0A401QJA7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01164864">
        <property type="protein sequence ID" value="GCB85434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10071890at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="137" mass="15936" checksum="DEF69B75C1F2EFA5" modified="2019-05-08" version="1" fragment="single">EGMKRQRSEGAKRQQSEGASRLRSEVTKRQRSEGAKRHTERRSEESAERRSEETHLVKERRVSGVKEQRVRGVKERRDSGAKERRVSGVKERRDRRSEGAKRQRSEGAKSQRNEGAKRQRSEGVKSQRSEGSERHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJE9</accession>
    <name>A0A401QJE9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01160380">
        <property type="protein sequence ID" value="GCB85474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJE9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="62" mass="6518" checksum="0BE34D7A33788B72" modified="2019-05-08" version="1" fragment="single">MEWNQGDKGVELGDREVEQGDKGVELGVKGLQLGDKGVELGDKGVELGVEGVEPGDKGVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJF5</accession>
    <name>A0A401QJF5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01162054">
        <property type="protein sequence ID" value="GCB85505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QJF5"/>
    <dbReference type="OMA" id="FHTNTCS"/>
    <dbReference type="OrthoDB" id="16955at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008614">
        <property type="entry name" value="FIBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223:SF2">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05427">
        <property type="entry name" value="FIBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="10800" checksum="BFE0B0BC1A7BE1C3" modified="2019-05-08" version="1">MAVELDVFVGNTTLIDKDVYQLWLDGYSVSDAVTIRIQSGILEQTGATQDVLESDTMDHYRAFQMLERLLHSPSKLTNQLLFQIPPPMQSMLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK56</accession>
    <name>A0A401QK56_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01194675">
        <property type="protein sequence ID" value="GCB85766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK56"/>
    <dbReference type="STRING" id="75743.A0A401QK56"/>
    <dbReference type="OMA" id="AGWYPAG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="337" mass="38692" checksum="1A43BE5746E12094" modified="2019-05-08" version="1" fragment="single">YYPDSYYPDSYYPDSYSPDSYYPDSYYPDSCNPDSYYPDSYYPDSYYPDSYSPDSYYPDSSYPDSYYPDSCYPDNNYPDSYYPDNYYPDNYYPDSYNPDSSYPDSDYADSYYPDSYCPDSYNPDSYYPDSYYPDSYCPDSYNPDSYHPDSYYADNYYPDMYYPDSYCQDSNNPDSYYPDSYYPDSYCPDSYNPDSYHPDSYHADNYYPDMYYPVRSYPDSYNPDTTSQTATMQTATVQTATVQTATTSTATIKTTAIQTATIQTATIQTANMQTATMQTATIQRATMQTATIQTAAMQTNTIPTAAIHTAAIQTATIQTAANQTAAIQTDISRQLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKA6</accession>
    <name>A0A401QKA6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01198444">
        <property type="protein sequence ID" value="GCB85748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKA6"/>
    <dbReference type="STRING" id="75743.A0A401QKA6"/>
    <dbReference type="OMA" id="HGADKHG"/>
    <dbReference type="OrthoDB" id="10002522at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="244" mass="24029" checksum="44D91D7381FBFD2B" modified="2019-05-08" version="1" fragment="single">MHGVDNHGADNHGADKYGADNHGADNHGADNHGADKYGAVKHGADKHGADKHGAGNHGADKHGADEHGADEHGADNHGADNHGAENHGADKHGAGNHGADKHGADKHGAGNHGADKYGAVKHGADKHGADKHGAGNHGADKHGADKHGADEHGADNHGADNHGVENHGADKHGAGEHVADNHGAGNHGADKHGAGNHGADNHGADNHGAGNHGADKHGADNHGAGKHGAGKHGAGKNGADKHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLK7</accession>
    <name>A0A401QLK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Murine leukemia virus integrase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0026927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01258947">
        <property type="protein sequence ID" value="GCB86269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLK7"/>
    <dbReference type="STRING" id="75743.A0A401QLK7"/>
    <dbReference type="OrthoDB" id="8947436at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Murine leukemia virus integrase C-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB86269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="165" mass="18588" checksum="8CDD53F83E019403" modified="2019-05-08" version="1" fragment="single">QEKAKEEESPATEHQIRPGDQVYIRKFRRRWNEPRREGPFEVTKVSPTALQVEGSTLWYHLNHCTRTVTGVGERREIEDSGAAGRSSSEEEIEQHEETRGEEEQSQSRPGGVDDDESGSVHELADDTNAHPGPVSQDAEGGENREGPSFPTWDLETISFEDFLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMA0</accession>
    <name>A0A401QMA0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01302739">
        <property type="protein sequence ID" value="GCB86509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMA0"/>
    <dbReference type="STRING" id="75743.A0A401QMA0"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="63" mass="7211" checksum="B5DADAE330756470" modified="2019-05-08" version="1" fragment="single">IEEEIQGCLVFLRSVYGVFGFSFQLNLSKRTEVFLGDVNLWNQAEKASDNWTVQVDVGKPSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMQ7</accession>
    <name>A0A401QMQ7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01335458">
        <property type="protein sequence ID" value="GCB86697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMQ7"/>
    <dbReference type="OMA" id="YSMEQEQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="136" mass="15394" checksum="51CD5992CC5FBFC4" modified="2019-05-08" version="1" fragment="single">SVTDWGEDSVTAWAEDSVTDRAEDSVTDWVEVSVTDRTEDSVTDRGQDSVTDWAEDSVTDWGEDSVTDWVEVSVTDRTEDSVTDRREDSVTDWVEDSVTDRRDDSVTDRSADSVTDRRVDPVTDRGYDSVTDRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNJ9</accession>
    <name>A0A401QNJ9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01384334">
        <property type="protein sequence ID" value="GCB86987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNJ9"/>
    <dbReference type="OrthoDB" id="8842296at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="120" mass="12784" checksum="20CD56CB4E9403DB" modified="2019-05-08" version="1">METGIPVETGGAGIPVEIGGAEIPLETGGAGIPAVSGGAGIPVETGRAGIPVETGGAGIPVETGIPVETGGAGILWRQEEQESPWRQEEQESLWRQEEQESLWRQEEQESLWREEEQEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHL7</accession>
    <name>A0A401NHL7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0012727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006234">
        <property type="protein sequence ID" value="GCB60347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHL7"/>
    <dbReference type="STRING" id="75743.A0A401NHL7"/>
    <dbReference type="OMA" id="SALECRY"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19354">
        <property type="entry name" value="Wnt_Wnt9b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000002">
        <property type="entry name" value="Protein Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF84">
        <property type="entry name" value="PROTEIN WNT-9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019516718" description="Protein Wnt" evidence="12">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB60347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="358" mass="40162" checksum="78C79D399921FCD8" modified="2019-05-08" version="1">MRCRLPSAGFLIKLLTAASIITPGAPHFGLTGKEPLVLSTPLLEDSDPGNVHLKQCDSLKLFRRQKRLCRREPGLAEGLRDAIRLSALECRYQFRTERWNCSLEGRGSLIKRGFKETAFLFAISSAGLTHSLAKACSSGRMERCTCDESPDLENREAWQWGGCGDNLKYSIKFIKHFLGQRKASKDLRARVDMHNTNMGIKAVKSGLKTTCKCHGVSGSCAVRTCWKQLSSFHETGKLLKLKYETAVRVHSITNDATGETELISPKKHSYTLKNHIPRTTDLVYIEDSPNFCRPSKYSPGTAGRVCSKETNCESMCCGQGHNTQSLLVNRPCHCQVQWCCYVECQQCSQREEIYTCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK60</accession>
    <name>A0A401NK60_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0007019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002469">
        <property type="protein sequence ID" value="GCB61266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK60"/>
    <dbReference type="STRING" id="75743.A0A401NK60"/>
    <dbReference type="OMA" id="KPENNGY"/>
    <dbReference type="OrthoDB" id="5914531at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09945">
        <property type="entry name" value="SH2_SHB_SHD_SHE_SHF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000021">
        <property type="entry name" value="Putative SH2 domain-containing adapter protein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF33">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING ADAPTER PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="288"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB61266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="388" mass="44431" checksum="A474392A473DD9AB" modified="2019-05-08" version="1">MAKWLKDYLSFGSRRVPPQPPKRDYSESEILKAYRAQRNLDFEDPYEESEGRARASEGEHPLGLSSSQHQKPASPDIKYVSPKHRLIKVDSTDLGCRAKILGTEEAKGKPETNLADDDYSDPFDIRHESKGETKDEEEVENNGYMEPYEAQRVIAELQRKGEKKREKGLQLYDTPYEPQDHDAVSDAENAASQKIRESRLPQDDERPADEYDQPWEWKKDHISKAFAVQFDGCDWDRSSPSAKDRLRQQKQLSPLAAGSKYTKPQTPEHSSSLPERVDPALPLEKQVWYHGAISRADAENLLMLCKECSYLVRNSETSRNDYSLSLRSSQGYMHMKFSRTKDCKYILGQNSPPFDSIPEVINHYTSHKLPIKGAEHLSLLFPVTVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK73</accession>
    <name>A0A401NK73_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005072">
        <property type="protein sequence ID" value="GCB61262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK73"/>
    <dbReference type="STRING" id="75743.A0A401NK73"/>
    <dbReference type="OrthoDB" id="10072099at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031809">
        <property type="entry name" value="CCDC158"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47615">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47615:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15921">
        <property type="entry name" value="CCDC158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8662" checksum="1C15360AF5A5FAD1" modified="2019-05-08" version="1">MSAPYSENELHFQSADTDQMDVAGQACKKLQNKLDGLQNLVEDLQLKNHEMSSMIRNQEKRIKRVKDREKMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKC2</accession>
    <name>A0A401NKC2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0012890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006375">
        <property type="protein sequence ID" value="GCB61297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKC2"/>
    <dbReference type="STRING" id="75743.A0A401NKC2"/>
    <dbReference type="OMA" id="KIACEMM"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19875">
        <property type="entry name" value="DSRM_EIF2AK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="308"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB61297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57363" checksum="6BD93B25FC7BBFFB" modified="2019-05-08" version="1" fragment="single">PHGTTTPSTSPAGMGNYISKLNEYGQKSDKHVEYIIKQLDTGLDHVQKFSSIVVIDKKAYPIGYGKSKQDAKREAARLACEEIYHIPSLCKDMANINVEKDEEFKSFSEDSGGQNTQSSKEDQADENGRRIEDFTATCMDGGSADTNSGMLNPVGALNEYCQKRKLTCYVEEVKKRGLAHSPEFTLQYVIDGKKFPNASAENKQKARRKAAILALKELKISWQTQDELGRVSSDGLSLRRSSEHSNGSSFIIFKHTNSITNGVRYNFLTDLPMRLAPTFKTMDSESGFTSSQSNSNIQDQDMEMITGFSDFELIGKGGFGSVYKAKNVVDKKYYAIKEVGLKNDFKVSSQNSDRIEQSLFIQMELYEKNLKEWVTDLANSKPDQKEVALSIFSQLLDGVVYIHQNRMIHRDLKLKLEKYNHKVDIFALGLIFFELLWIQIGTVMEKTEKWREIRTGNFPQGFDNNYNFQSFLIRKMLSEAASERPEAKEIKWKLESNEIQESKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLL0</accession>
    <name>A0A401NLL0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HEXIM P-TEFb complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005134">
        <property type="protein sequence ID" value="GCB61756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLL0"/>
    <dbReference type="STRING" id="75743.A0A401NLL0"/>
    <dbReference type="OMA" id="ESENQCD"/>
    <dbReference type="OrthoDB" id="10058500at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB61756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29293" checksum="060927DACC9934E6" modified="2019-05-08" version="1">MGEQVVAEGSAGEQDVKRSCSPGGGGTGRASRAPPARRRRQQPRKRHRWRRPSKKKRRWKPYFKLSWEEKKKLDERESVRAAKTRAEMFAKGFTVAPYNTTQFLMEEHNQEEPDLNTGGPAACPRRAAQADRPSEEEPQDSDGMGGGGEFLRRDFSETYERYHAESLQNMTKQELVREYLELEKCLSRLEDENNRLRGRPDGVRAAARGAEPAASEGRLRELEREMERLKTENQRLELENELYKRDGRCLENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM28</accession>
    <name>A0A401NM28_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006468">
        <property type="protein sequence ID" value="GCB61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM28"/>
    <dbReference type="STRING" id="75743.A0A401NM28"/>
    <dbReference type="OMA" id="RQARIMK"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002753">
        <property type="term" value="P:cytoplasmic pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043529">
        <property type="entry name" value="ALPK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46747">
        <property type="entry name" value="ALPHA-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46747:SF1">
        <property type="entry name" value="ALPHA-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28334" checksum="59E55FC16DA5F325" modified="2019-05-08" version="1">MNNQEVVALLQECKRTLDAPPSEPSEEDKTEYWQCEASLSADLRTLLEQAKEMKWPFVPERWQYKQEVCPEDKTNLKDIISEKLPDLLVFLKASVSVGDYASAAATVFLIDRFLYWVDASSKLLQVAKGLHKRRLEIPIAPQVVVRQARVSINSGKLLKAEYILSSLINNSGATGNWVYEKKSDRVLVQAVSIQIRGQILQKLGLWYEAAELIWASIVGFYELPHPDKKMVQMDIEDIDIVSHWCLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NML2</accession>
    <name>A0A401NML2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRFIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007745">
        <property type="protein sequence ID" value="GCB62077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NML2"/>
    <dbReference type="STRING" id="75743.A0A401NML2"/>
    <dbReference type="OrthoDB" id="10028421at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019139">
        <property type="entry name" value="LRRFIP1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09738">
        <property type="entry name" value="LRRFIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10062" checksum="A9184D4F2C4E11C5" modified="2019-05-08" version="1">MWLTLDVPCDFRVIKFIDEKEALLEQIKKLKAQLDERSKSGKAEKAASSDTILENGTDVQMIEVQRLNLVDSLGASLIANSTNGIPLSQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN31</accession>
    <name>A0A401NN31_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000002">
        <property type="protein sequence ID" value="GCB62237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN31"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB62237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10800" checksum="03260621AD4AF4D6" modified="2019-05-08" version="1">MANYCGTCRQLSEPSMNQQLEKKRGNWREKSIILEIISVMTAFNQFQGSEDCLLMPLFLIPWAMANTESESMVKNPSLDIVQVLLHLDMDCFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNX7</accession>
    <name>A0A401NNX7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amyloid-beta A4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0014512</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007815">
        <property type="protein sequence ID" value="GCB62595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNX7"/>
    <dbReference type="STRING" id="75743.A0A401NNX7"/>
    <dbReference type="OMA" id="ALANEVX"/>
    <dbReference type="OrthoDB" id="6147836at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030546">
        <property type="term" value="F:signaling receptor activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22607">
        <property type="entry name" value="Kunitz_ABPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.140:FF:000001">
        <property type="entry name" value="Amyloid beta (A4) protein b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.770:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.140">
        <property type="entry name" value="Amyloidogenic glycoprotein, copper-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036669">
        <property type="entry name" value="Amyloid_Cu-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008155">
        <property type="entry name" value="Amyloid_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011178">
        <property type="entry name" value="Amyloid_glyco_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019744">
        <property type="entry name" value="APP_CUBD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103">
        <property type="entry name" value="ALZHEIMER'S DISEASE BETA-AMYLOID RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103:SF7">
        <property type="entry name" value="AMYLOID-BETA PRECURSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12924">
        <property type="entry name" value="APP_Cu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00203">
        <property type="entry name" value="AMYLOIDA4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00006">
        <property type="entry name" value="A4_EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89811">
        <property type="entry name" value="Amyloid beta a4 protein copper binding domain (domain 2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00319">
        <property type="entry name" value="APP_CUBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51870">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0034">Amyloid</keyword>
    <keyword evidence="14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="E1" evidence="18">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="17">
        <location>
            <begin position="198"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="E2" evidence="19">
        <location>
            <begin position="262"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="GFLD subdomain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="CuBD subdomain" evidence="13">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB62595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="467" mass="53331" checksum="BD054B1FBD902912" modified="2019-05-08" version="1" fragment="single">VYPDLQITNVVEANQPVTIQNWCKKGRKQCKGHPHIVVPYRCLVGEFVSDALLVPDKCKFLHREKMDTCESHLYWHTVAKETCGDKIMNLHDYGMLLPCGIDEFRGVEFVCCPIPEENDKIDSDMDEDSDVWWGGDDADYADGSDKIIEEQPMEEESDIDDDLDDEDDEDQYEDPTEHTTSSTTTTTEAIEEVVREVCSEQAETGPCQAMIPRWYFDISEGKCAQFIYGGCGGNRNNFASEEYCLAVCNSVIPTTAASTPDAVDKYLETPGDENEHAYFQKAKERLEAKHRERMSKIMREWEDAERQAKNLPKADKKAVIQRFQEMVESLEQEAASERQQLVETHMARVEAMLNDRRRIALENYLAALQADPPRPRHVLSALKKYIRAEQKDRQHTLKHFEHVRMVDPKKAAQIKSQVMTHLRVIDERMNQSLSLLYKVPSVAEEIQDEVGAALWISAAAVRRGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQK0</accession>
    <name>A0A401NQK0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRP2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0004356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May act as an adapter that regulates LRP2 function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001290">
        <property type="protein sequence ID" value="GCB63127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQK0"/>
    <dbReference type="STRING" id="75743.A0A401NQK0"/>
    <dbReference type="OMA" id="VESCKQH"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052323">
        <property type="entry name" value="LRP2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44554">
        <property type="entry name" value="LRP2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44554:SF1">
        <property type="entry name" value="LRP2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="359" mass="40932" checksum="0D23A9FEC89A3B06" modified="2019-05-08" version="1">MERKREIRPLVQSTNRLKLTCELLPQKRTKKCPSLQDRGIKNNAAQTLAESFKITNEVKRADEFLRKRIKEGDLQAIFLLGQLYFEEGCYETAFAEFNKIKDTDIQALYQLSVMYYDGLGVKANPALGVEYMNRIINSDDTRARRLKFAAFYNLGRASFEGFGLQQSDKEAERLWLIAADDGNPKASVKAQTILGLFYCRPESQDLQKAFFWHSEACGNGSLESQGVLGLLYLTGHGIRKDKYSAWVCLKEASSRGNVYAQGHLVADFYSRKLYHSTVELAQRVAQYDNVPQIAKETECMPSYIAKGIAMAAFYYARCLQLGLGTKQNQVEARKYYYKAINMDRDVATDLHFQVIMEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSI9</accession>
    <name>A0A401NSI9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006699">
        <property type="protein sequence ID" value="GCB63829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NSI9"/>
    <dbReference type="OMA" id="FTNEQQG"/>
    <dbReference type="OrthoDB" id="9927874at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042772">
        <property type="entry name" value="SH3TC1/SH3TC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22647:SF3">
        <property type="entry name" value="SH3 DOMAIN AND TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22647">
        <property type="entry name" value="SH3 DOMAIN AND TETRATRICOPEPTIDE REPEATS CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="309"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB63829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1352" mass="154339" checksum="7169590636BABA87" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSK3</accession>
    <name>A0A401NSK3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004048">
        <property type="protein sequence ID" value="GCB63827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSK3"/>
    <dbReference type="OMA" id="DSNIKMF"/>
    <dbReference type="OrthoDB" id="6334002at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041404">
        <property type="entry name" value="DUF5588"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31919">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31919:SF1">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17826">
        <property type="entry name" value="DUF5588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB63827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="128" mass="14315" checksum="BEF77D3B41CD23FD" modified="2019-05-08" version="1" fragment="single">LLLQLVKAQQASFVLERNLTVQEEIRQQLNNLELREEALNAISKTMGEDLLLDRFKNGAETERPGTFPNSSSLTCVAIESGSDFEERWFKKLRVSDISLVARGAENNVRVCDSNIKMFQKPLASSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTD9</accession>
    <name>A0A401NTD9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Kv channel-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0000242</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000043">
        <property type="protein sequence ID" value="GCB64119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTD9"/>
    <dbReference type="STRING" id="75743.A0A401NTD9"/>
    <dbReference type="OMA" id="VKRANTR"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000043">
        <property type="entry name" value="Kv channel-interacting protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF30">
        <property type="entry name" value="KV CHANNEL-INTERACTING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="8" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB64119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="188" mass="22012" checksum="352E7B80042F90C9" modified="2019-05-08" version="1">MATVCHRPEGLEQLEAQTKFTKKELQILYRGFKNECPSGIVNEETFKDIYAQFFPQGDASTYAHFLFNAFDTDHNGSVSFEDFVMGLSVLLRGTIQDKLKWAFNLYDINKDGYVTKEEMLDIMKSIYDMMGKYTYPILREETPRQHVEIFFQKMDKNKDGVVTIDEFIDTCQKDENIMKSMQLFENII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTQ9</accession>
    <name>A0A401NTQ9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein max</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myc-associated factor X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0007506</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002734">
        <property type="protein sequence ID" value="GCB64224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTQ9"/>
    <dbReference type="STRING" id="75743.A0A401NTQ9"/>
    <dbReference type="OMA" id="YMDAHEL"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11406">
        <property type="entry name" value="bHLHzip_Max"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000023">
        <property type="entry name" value="MAX isoform 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB64224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="17545" checksum="74554DF6EE3867F7" modified="2019-05-08" version="1">MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKVCVLASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNTLLEQQVRALEKARAAAQLQANFSSSDSSLYTNPKGSAVSAFDGGSDSTSESETEEPQTRKKLRMEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU09</accession>
    <name>A0A401NU09_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006757">
        <property type="protein sequence ID" value="GCB64322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU09"/>
    <dbReference type="STRING" id="75743.A0A401NU09"/>
    <dbReference type="OMA" id="WESMFLK"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000024">
        <property type="entry name" value="Caspase 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF41">
        <property type="entry name" value="CASPASE 14, APOPTOSIS-RELATED CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB64322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24074" checksum="3D934AA41E21D7BB" modified="2019-05-08" version="1">MDTKKLHKVLFNLGFEVAFKIDYTAEEILQEYRKESCQTHGSCFISIISSHGEEGVIYGSDSCPVKLGDIYSMFTPKSCPSLAGKPKIFFIQACRGAELDDGAFVETDRGTETPSGHPPQNPFSHYEAVPEDTAVHFSTSSDHAAFLSPGGSVFLQSLCRVLDGNGRHLEILRIMTRVNGLVAWNFESRGQRLGGKKQMPCFITKLLREAFPFSDGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUC8</accession>
    <name>A0A401NUC8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0011759</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005459">
        <property type="protein sequence ID" value="GCB64485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUC8"/>
    <dbReference type="STRING" id="75743.A0A401NUC8"/>
    <dbReference type="OMA" id="RXEREDH"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22718">
        <property type="entry name" value="FHA_SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000008">
        <property type="entry name" value="smad nuclear-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="13">
        <location>
            <begin position="251"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB64485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="364" mass="41945" checksum="F71997A73B87C083" modified="2019-05-08" version="1" fragment="single">SPAGKMEAPGRRRASHSPEAERHRPRIKREGAASASKQRPSSSGSSGGSVSPPGHWQSSSPGRRKQHSRPEGKWKRERHDHPRRDHAERRHRDRSEGNEHRRKKNSDRERHRECADRGRTHSKRNGGSHAEAGMSGRDREAQLFGTQQAEREYYNERRHQNRNQCHMISDANPESELIDSQANSGNAAQVKEEPNFELSGALVEDTNTFRGVVIKYNEPPESRIPRKRWRLYPFKNDEPLPVMHIHRQSAYLLGRQRRVVDIPIDHPSCSKQHAVLQYRLVEFTRSDGTSGRRVRPYIIDLGSANGTYLNNQRIESQRYYELREKDLLKFGFSSREYVILHDCSDTAEVDAKEGQQEEDEGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVB9</accession>
    <name>A0A401NVB9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0004667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus inner membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001396">
        <property type="protein sequence ID" value="GCB64794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVB9"/>
    <dbReference type="STRING" id="75743.A0A401NVB9"/>
    <dbReference type="OMA" id="TELGHFW"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000009">
        <property type="entry name" value="SUN domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032680">
        <property type="entry name" value="SUN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040994">
        <property type="entry name" value="Sun_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF23">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18580">
        <property type="entry name" value="HTH_SUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09387">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="816"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB64794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="979" mass="110172" checksum="9528A0E3146F4ABB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVR8</accession>
    <name>A0A401NVR8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0000351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01000066">
        <property type="protein sequence ID" value="GCB64971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVR8"/>
    <dbReference type="STRING" id="75743.A0A401NVR8"/>
    <dbReference type="OMA" id="CSWTENV"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF5">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46596">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, dispensable insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="13">
        <location>
            <begin position="375"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="659"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB64971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="780" mass="91949" checksum="2A41126162715D32" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWJ8</accession>
    <name>A0A401NWJ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01001425">
        <property type="protein sequence ID" value="GCB65245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWJ8"/>
    <dbReference type="STRING" id="75743.A0A401NWJ8"/>
    <dbReference type="OMA" id="LSWCSID"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13979">
        <property type="entry name" value="STKc_Mos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000490">
        <property type="entry name" value="Proto-oncogene serine/threonine-protein kinase mos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000316">
        <property type="entry name" value="Proto-oncogene serine/threonine-protein kinase mos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF285">
        <property type="entry name" value="V-MOS MOLONEY MURINE SARCOMA VIRAL ONCO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="59"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB65245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="335" mass="37647" checksum="E124D0F26A6511A2" modified="2019-05-08" version="1">MPSPIPIHRLLPKGFSPTLTLRPCSSPNRTPGKGPQFSFTKPHWALLRRSWYTVIWDELKLLDLLGSGGFGWVYRGTYYGQTVAIKKVRKCTKNRLAARQSFWAELNVAHLVHENIVKIVAATTSVPSDPAIEDSVGTIIMEYAGGTSLDHRIYNCAEPLDIRGCLQFSNDIMSGLAFLHSHHIVHLDLKPANVLITEAGRCKIGDFGCSHKLTTGSDLTPNVQWRHLAGTYTHRAPELLRGCNATLKADIYSFAITLWQMMSRDQPYSGDRQCVVYAVVAYNRRPSFSPIFNETPMGRQIRSIINNCWEVEPNDRPSAKELLESINCLAAQLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX04</accession>
    <name>A0A401NX04_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Merlin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Moesin-ezrin-radixin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Neurofibromin-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Schwannomin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0004784</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001435">
        <property type="protein sequence ID" value="GCB65409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX04"/>
    <dbReference type="STRING" id="75743.A0A401NX04"/>
    <dbReference type="OMA" id="IKRWWIN"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17186">
        <property type="entry name" value="FERM_F1_Merlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000103">
        <property type="entry name" value="Merlin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.450:FF:000001">
        <property type="entry name" value="radixin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FERM" evidence="18">
        <location>
            <begin position="14"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="311"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="68"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR002305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB65409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="588" mass="69147" checksum="57DEE8A7DAA68A0C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXN1</accession>
    <name>A0A401NXN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0013479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006905">
        <property type="protein sequence ID" value="GCB65610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXN1"/>
    <dbReference type="STRING" id="75743.A0A401NXN1"/>
    <dbReference type="OMA" id="RTNECIA"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000230">
        <property type="entry name" value="Transducin beta-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="224"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="391" mass="44063" checksum="897F1B94F30B7DE8" modified="2019-05-08" version="1" fragment="single">RLKEGFIVSGSQDCTLKLWALAKSLGVNDNEKITEPEILHADLTEKVHDKDINSVVVSPNDKLVATGSQDRTAKLWSTSDFSLVGVFRGHKRGIWSVQFSPMDQILATSSADGTVKLWGLQDFNCLKTFEGHDASVLKTIFVSRGTQLLTSGSDGLLKLWTIKTNECIKTLDVHEDKVWGLHSSKNDDLVVTGATDSCIVIWKDVTEIELAEEQAKQEEQILKQQELSNLLHEKKYVKALGLAISLNQPQTVLTVIKAILGESNGQVRLESTILKLRQDQKESVLKFCIIWNTNSKNCHEAQSIIQILLRNETPEQLLQYNGIKAALEGLIPYTERHFQRLSRLFQASMFLDYMWQSMRLIEKSSDSDKQAEEMEIETFFPTDKKAVNTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXT2</accession>
    <name>A0A401NXT2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ciliary microtubule inner protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0000452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CIMIP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000086">
        <property type="protein sequence ID" value="GCB65665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXT2"/>
    <dbReference type="OMA" id="PTINFTY"/>
    <dbReference type="OrthoDB" id="8181742at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052329">
        <property type="entry name" value="CIMIP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924:SF1">
        <property type="entry name" value="PROTEIN FAM166C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924">
        <property type="entry name" value="UPF0573 PROTEIN C2ORF70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB65665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="248" mass="28337" checksum="33DCD2ECC2550244" modified="2019-05-08" version="1">MASRNAGTLITNYNATYIPPALMPGYRGYIPTINFTYGNTYGNTTRKYFQDFRLSALNTSQSPYSKGGQFPTIYSNDPSLVIADRSHNRNRWLDAPQWSRYDLDFDRNEELKKFDKLAQQHRVNYKDKTGTVRRVDHFVMAGTEVDTFPCLPNIQRNKDVCPSPNYMAWPRDYLERLCKDNLEAALCISSKGHSGDFNDAPPYLHCPRVDGGMLFGANGPTSPLRCSPQKMTDYQAGYDRKTYSCEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY54</accession>
    <name>A0A401NY54_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent RNA helicase DHX38</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">DEAH box protein 38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">scyTo_0000470</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01000092">
        <property type="protein sequence ID" value="GCB65818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY54"/>
    <dbReference type="STRING" id="75743.A0A401NY54"/>
    <dbReference type="OMA" id="IFHARAP"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17983">
        <property type="entry name" value="DEXHc_DHX38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004736">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="578"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="767"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="77"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1241"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1191"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="143"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GCB65818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1263" mass="144839" checksum="A8656BD872DD22D2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYA0</accession>
    <name>A0A401NYA0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005602">
        <property type="protein sequence ID" value="GCB65834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYA0"/>
    <dbReference type="STRING" id="75743.A0A401NYA0"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026519">
        <property type="entry name" value="THAP7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47502">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47502:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="274" mass="30070" checksum="71852EC7F00B64D2" modified="2019-05-08" version="1" fragment="single">GYHRLRDDAVPTIFQPCPLGKMALSDVNRGNSIGIVCSSECLPDGRSLPAADLKDPGTSSEMGFSISQDGAAFALGYSHPQDKVSESLCLYETSSPDVLLSTNQPELETTPPSVIYLIEVNSQSAKFEAACNTEETAKDISAPQPATLTEHLADCQVELDNDRGPVPIALYMARIPSPPPKPGAYIAIEHSYTVGCPLVWKMKAEALKEAFEKVSKELRASRKRESRLRARITSILRPRSRGLRDRCTESDLTEDYQSQFEMFEVQVVDEAMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ40</accession>
    <name>A0A401NZ40_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008251">
        <property type="protein sequence ID" value="GCB66133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ40"/>
    <dbReference type="OMA" id="FWDTAGW"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="468" mass="53636" checksum="1B61806D814FD229" modified="2019-05-08" version="1">MDSLETDNCSELPCQPQSANEADMSSKRDANSLDHSDEFLTDPLIRHGSCNSSWWKVLTDSDDSSEGNVENVNESDGFLTGSLRQHGSCDSSWWKVLTDSDISSEGNVEHVDEFPEDLPMIPSIWFTIKPHELSDMGVREIKENNLVEDSSWGEESTDSEFSSNNKAEHLDKHLSKQKYPHTSYSRHHVVHRLSIDQSALETLRSHLCMYRPPEKCVDCTNILLFGMVGAGKSSTINTFLSALDPDRRTMNCAPTGQHPDSLTVKLTSYKSNSLKFWDTAGWNSLDDPVKTKKVFRMILEGRVPLGTNLKNFNPDADDARNVVIQENVIHGVAFIFNTFTMDNIDLDLLKQFQDLQNIVAQKYIYKIVIGTNFDRLRIPAKSYNHIYENAKLKRKFAKLSDYIGMKKRTMFVISNEWKGYKIEKTKCVLALFILKNMPIHWDYDTFSTLTTMRFSEKWLKYFTVFITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZS0</accession>
    <name>A0A401NZS0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001498">
        <property type="protein sequence ID" value="GCB66353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZS0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="100" mass="10983" checksum="4E12668FA64FA478" modified="2019-05-08" version="1">MLSDNLKVLRGIRNKLSGGGTRGVQQCVNIAVDLSKSPIWQAVPKNFCGLQGDGTAWRKAALRRFPVGARSPPVEGRMRRDVSCVHRSGSHVRKRKTSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZU2</accession>
    <name>A0A401NZU2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RIIa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008283">
        <property type="protein sequence ID" value="GCB66387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZU2"/>
    <dbReference type="STRING" id="75743.A0A401NZU2"/>
    <dbReference type="OMA" id="DEAMQTD"/>
    <dbReference type="OrthoDB" id="252964at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12103">
        <property type="entry name" value="DD_RIIalpha_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000002">
        <property type="entry name" value="cAMP-dependent protein kinase type II-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="2">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="11830" checksum="64E8EF8EB68A5FD8" modified="2019-05-08" version="1">MNIEIPPGLTDLLQGYTVEVLRHRPSDLVEFAIQYFTELKEKEAGGRGRFRTDDHLMQTESNGEEDESESDSGSEFEERHPIWLHHSLLSISLSMSLASVKIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0S3</accession>
    <name>A0A401P0S3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0007928</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002962">
        <property type="protein sequence ID" value="GCB66735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0S3"/>
    <dbReference type="STRING" id="75743.A0A401P0S3"/>
    <dbReference type="OMA" id="MPAMYKE"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF5">
        <property type="entry name" value="SENSORY ORGAN HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB66735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="250" mass="28386" checksum="D670AEE21CB8F5B4" modified="2019-05-08" version="1">MMDKGESPQCQPLSLKFTIDSILKPSPKCRELKQHERPKQQVTPTSEIKSRSEATRTDMRHTKEYRKAVQETMDAAYLASSPLGFSVDANRSVKSPESYGSLETADHSDDSAKAKHSKKAKVLGKKKTRTIFSKSQIFQLESTFDLKRYLSSAERACLANSLQLTETQVKIWFQNRRNKLKRQLSAELEVTNTAESAPKIVQMPAMYKESSFLRRCLLPVSFPVLYPGTSTPYLCFPEARKYLHVLDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0T3</accession>
    <name>A0A401P0T3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox protein MOX-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mesenchyme homeobox 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0000630</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000121">
        <property type="protein sequence ID" value="GCB66714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0T3"/>
    <dbReference type="STRING" id="75743.A0A401P0T3"/>
    <dbReference type="OMA" id="CMRNSHS"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061053">
        <property type="term" value="P:somite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000109">
        <property type="entry name" value="Homeobox protein MOX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF8">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 14 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0371">Homeobox</keyword>
    <keyword evidence="11 14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="17">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="14">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="79"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB66714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="288" mass="31883" checksum="3246851578941DCB" modified="2019-05-08" version="1">MDQGAGSCMRNSHSGAAVWGCMRNPHAGAGVPGLHHYPSPFSFYKKSDAADFSAYSDFTSPCLVSAAHSFPGEERLYVDHHPGRFPPRSEWHIPPPPPPPPPPPPPPPTAARDRQTSCLSASSANFETSGDSQPAGCAGTGDYSSQRGTAASDIDKKAARRKRDVLETQDSNYKSESNSKARKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQPVSPQSQEPDDVDCVTPDSDLRNADGKGHMVGLVDNKETIQDSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0X2</accession>
    <name>A0A401P0X2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008332">
        <property type="protein sequence ID" value="GCB66769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0X2"/>
    <dbReference type="STRING" id="75743.A0A401P0X2"/>
    <dbReference type="OMA" id="SARRMCH"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB66769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="192" mass="21377" checksum="BE7E5D4A8EAEB781" modified="2019-05-08" version="1">MYNCDAYCIPALSIRQSKISAVVLRTTKRYQTFYDGSSASPVGVCHISMADPFCQKTREVLLDVVKKLGIRHHAKGTMVTIEGPRFSSRAESLMFRQWQGDVINMTTVPEVALAKEAGICYASIAMATDYDCWKEHEEAVSVEKVLKIMKENANKALSILLTAIPQVASMNWSECIKSLRVSQEGSVMLPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2E7</accession>
    <name>A0A401P2E7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Photoreceptor-specific nuclear receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nuclear receptor subfamily 2 group E member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Retina-specific nuclear receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0005111</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001564">
        <property type="protein sequence ID" value="GCB67329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2E7"/>
    <dbReference type="STRING" id="75743.A0A401P2E7"/>
    <dbReference type="OMA" id="HLTKIPM"/>
    <dbReference type="OrthoDB" id="5774777at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06970">
        <property type="entry name" value="NR_DBD_PNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06950">
        <property type="entry name" value="NR_LBD_Tlx_PNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000022">
        <property type="entry name" value="Nuclear receptor subfamily 2 group E member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000028">
        <property type="entry name" value="Nuclear receptor subfamily 2, group E, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="18">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="19">
        <location>
            <begin position="164"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB67329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="406" mass="45202" checksum="2D6D54E37DC0FC62" modified="2019-05-08" version="1">MSSSPTESSVSPGLEDSQTVKTPSPGKSLSPVLMCKVCGDTSSGKHYGIYACNGCSGFFKRSVRRKLIYRCQAGTGMCPVDKAHRNQCQACRLKKCLQAGMNKDAVQNERQPRSTAQVRVDTAELDPDKEHIATTREPTVSSASTQGSASSNISSNQRPISPPNNHRFMASLMTAETCAKLEPEDVDENIDVTSNEPERSSSTEYQMSIYPPSSPECVYETSARLLFMAVKWAKNLPIFSNLPFRDQVILLEEAWNELFLLCAIQWSMPLESCPLLSLPELSHSPQGKSSSTMADVRILQEIMSRFKVIAVDPTEFACLKAVVLFKPETRGLKDPEQVENLQDQSQVMLGQHSRTHYPIQPVRFGKLLLLLPSLRFVPSDQIELLFFHRTIGNTPMEKLLCDMFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3H5</accession>
    <name>A0A401P3H5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0005183</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001589">
        <property type="protein sequence ID" value="GCB67705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3H5"/>
    <dbReference type="STRING" id="75743.A0A401P3H5"/>
    <dbReference type="OMA" id="ECRLYVF"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15220">
        <property type="entry name" value="7tmA_GPR61_GPR62-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="60"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB67705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="448" mass="50836" checksum="949AD96E93C317F2" modified="2019-05-08" version="1">MAAPVFAEWAWNTSIPGRQHRVSPTPMLFNQSLVSKDRDLVSQSIGLFFMLLVDLVGIIGNTAVMFVIIRTPLFKKFVFVFHLCLVDLTAALILMPLGMVSNSALFDNIMFGDTLCQIYLFLSMLFISASILSILAINVERYYYIVHPMRYEVRMTLKLVVSVIICIWIKAILMSIMSVLGWNSQAHVNNQCSWQWGGETYKKVYIIFFSLFYFLFPVLIILVVYCNMFKVARIAAMQHRPLPTWMDTPRQRSESLSSRSTMVASSGAPRASPQRTFGGGKAAIILILVGGQFVFCWLPFFAFHLHSTLNQSSGPLGLWETIVTWIGYTSFSINPFFYGCLNRQIRGELSKHLNCLFKHTLEEDLRLPSREGSIEENFMQFLQRTGCNTETRSSYDASSPKLDQSALGFRIPGQIAEETSEFLEQHIATDFTMSNSCIIMSRSPKHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6C6</accession>
    <name>A0A401P6C6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001649">
        <property type="protein sequence ID" value="GCB68630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6C6"/>
    <dbReference type="STRING" id="75743.A0A401P6C6"/>
    <dbReference type="OMA" id="SKESHIR"/>
    <dbReference type="OrthoDB" id="568502at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045931">
        <property type="term" value="P:positive regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042481">
        <property type="entry name" value="CCDC57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="401" mass="47517" checksum="556C8F6CBC222ED9" modified="2019-05-08" version="1">MLQEDNFDKLLAQKEQEWKDLQIRHIQSLETALQNSQAKLKDQQEKFNILKEDFLFNLKVLEERDRDLERYDAMFAQLKITENCKRAEISDLQIQIDKTQEIVAKETKTRIDLQFQYQQTVKTHQLEIEKIRSSNDSKIDGQRDEYKNLKQDLERKVQEVEGQLALQKQEMLAEFDADMRHREHEFTLRADEMSNAVLTSELKVKLLSKELELLREAGVKAGESLQRAEETNTKMEKELQRKELELKGVVALKKIRIKELEGKVNKMEIKLKKEEEIFQRKHCELDHFARERDAKLAATKGLHTEQIRELENNIRELQMSLETAEMEKRRMEWNHADATKEKEDVIEKLYGELSTVKTGWDSHIAQISKETVTKDMQIKMLQDQDSKLRTELARHKEDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6H3</accession>
    <name>A0A401P6H3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0008269</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01003132">
        <property type="protein sequence ID" value="GCB68717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6H3"/>
    <dbReference type="STRING" id="75743.A0A401P6H3"/>
    <dbReference type="OMA" id="GWSLENC"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900227">
        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046620">
        <property type="term" value="P:regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21778">
        <property type="entry name" value="MobB_LATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001246">
        <property type="entry name" value="Large tumor suppressor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000199">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase LATS1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049761">
        <property type="entry name" value="LATS1-like_MobB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE LATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBA" evidence="24">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="740"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="25">
        <location>
            <begin position="1046"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="228"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="387"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="608"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1143"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB68717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130763" checksum="F642704E6EEA40A7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6Z6</accession>
    <name>A0A401P6Z6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BEACH-type PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005932">
        <property type="protein sequence ID" value="GCB68886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401P6Z6"/>
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    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
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        <property type="entry name" value="NBEA-like_DUF1088"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF64">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06469">
        <property type="entry name" value="DUF1088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="2">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="181" mass="20491" checksum="26CEDE3C87318BC3" modified="2019-05-08" version="1">MCDHLIRAAKYRDHVTSTQLIQKIINILTDKHGAWGSSSLSRPREFWRLDYWEDDLRRRRRFVRNSFGSTHPEAALKAATEHGSEEDALVKGRQSIRTQAVGNQNSESEILLEGDDDTLTSLEEKEIDNMAGPVNFTTAVQLIAPAVVAKGTLSITSSELYFEVDDDDSGYKKLDPKVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7C3</accession>
    <name>A0A401P7C3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000203">
        <property type="protein sequence ID" value="GCB69022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7C3"/>
    <dbReference type="STRING" id="75743.A0A401P7C3"/>
    <dbReference type="OMA" id="CHYACAL"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB69022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8170" checksum="3244CB7341923598" modified="2019-05-08" version="1">MDRFGTCHYACALQQQGAATTVYCSIAPELEGLGGMYFNNCCRCQPSQKAQDEASASALWELSEGLIQERAGSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9Y8</accession>
    <name>A0A401P9Y8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0008471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003248">
        <property type="protein sequence ID" value="GCB69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9Y8"/>
    <dbReference type="STRING" id="75743.A0A401P9Y8"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="9320" checksum="6CDE116D714810DC" modified="2019-05-08" version="1" fragment="single">AISGHFDILFEKNCSNKVMFSTGPRSPQTHWKQAVFLLEQPIKVKKGDILQGKIACCKNRKDPRSLMITISINNVKQTYSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAP0</accession>
    <name>A0A401PAP0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001774">
        <property type="protein sequence ID" value="GCB70164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAP0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="88" mass="9547" checksum="B050F8270FCCC85D" modified="2019-05-08" version="1">MQSHIDNRHGGNEVGGVIEEEGLRGGGLKRRHICKANRGKGGVRSLDGEEKGHQPTEGKKQLNDDEPLQQGSGESDEAGRCRESWVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB12</accession>
    <name>A0A401PB12_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Leptin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_2000002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001791">
        <property type="protein sequence ID" value="GCB70312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB12"/>
    <dbReference type="STRING" id="75743.A0A401PB12"/>
    <dbReference type="OMA" id="AMETMIC"/>
    <dbReference type="OrthoDB" id="8964127at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003529">
        <property type="entry name" value="Hematopoietin_rcpt_Gp130_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010457">
        <property type="entry name" value="IgC2-like_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041182">
        <property type="entry name" value="LEP-R_IGD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF44">
        <property type="entry name" value="LEPTIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06328">
        <property type="entry name" value="Lep_receptor_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18589">
        <property type="entry name" value="ObR_Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01353">
        <property type="entry name" value="HEMATOPO_REC_L_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019170826" description="Leptin receptor" evidence="13">
        <location>
            <begin position="28"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="221"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="306"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="518"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="718"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB70312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1163" mass="133460" checksum="C8BAE1DCC884BFC8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDK3</accession>
    <name>A0A401PDK3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0005872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01001896">
        <property type="protein sequence ID" value="GCB71195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDK3"/>
    <dbReference type="STRING" id="75743.A0A401PDK3"/>
    <dbReference type="OMA" id="PLNIKEC"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="275"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB71195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="373" mass="41879" checksum="F0DC6499E38F9DF7" modified="2019-05-08" version="1">MEPVEKWHKDLLILKLLDKTLNSKENGTTGSCPNLVLSKSDQPDYKHITMTSTPKLPVRTHRPLCLSVSSDGNGRYAALETQDFKSSLKSQMVKADNTRASSSTGSLERASLFCASASNTSTSNLSSSNETLAKAKSSNRFSLFSPPWNSSSESDSNPPSRSGSKKLKNHHRKSLNKIDSPKDCKRSIPEQLQYSEPVIAKVTDHIYVGNLNAAYSGRILCKNNIDSIIDMSNLPGEFNMCLIPCTCSRNVKHSWSRLKVDINDFSNDDVFPLKHRCFEDINECINASTEKQKRVLIHCRDGYSLAPTCIIQYLMQKQNMQLMTAYEFVKAKYPLNIKECHQNLLVTLEKSLRPGNTNPECFKQALSRKMAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE53</accession>
    <name>A0A401PE53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gastrin-releasing peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_2000016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bombesin/neuromedin-B/ranatensin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000355">
        <property type="protein sequence ID" value="GCB71392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE53"/>
    <dbReference type="STRING" id="75743.A0A401PE53"/>
    <dbReference type="OMA" id="KDMMDYL"/>
    <dbReference type="OrthoDB" id="9879745at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000874">
        <property type="entry name" value="Bombesin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16866">
        <property type="entry name" value="GASTRIN-RELEASING PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16866:SF2">
        <property type="entry name" value="GASTRIN-RELEASING PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02044">
        <property type="entry name" value="Bombesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00257">
        <property type="entry name" value="BOMBESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0027">Amidation</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019491615" description="Gastrin-releasing peptide" evidence="10">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB71392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="17112" checksum="5A80C0341B427149" modified="2019-05-08" version="1">MGSEFILWKHRLLFSLIVLSIASSTVHYGLAAPVENQGSFPKMFPRGSHWAVGHLMGKKSVDDGLYANSDNMVHPVLSESAQQPEGNLQWAEMAKNFLSLWEGTPSRKVQQTREQFPVFNKKLWQTTDDDFKEMVDYLLQLMNPRDETPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFJ4</accession>
    <name>A0A401PFJ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the insulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002001">
        <property type="protein sequence ID" value="GCB71920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFJ4"/>
    <dbReference type="OrthoDB" id="9949698at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051042">
        <property type="entry name" value="Repro_Hormone_Insulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12004:SF3">
        <property type="entry name" value="EARLY PLACENTA INSULIN-LIKE PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12004">
        <property type="entry name" value="RELAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018998024" description="Insulin-like domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="9">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16931" checksum="27EA8E5558078E31" modified="2019-05-08" version="1">MKGLVFVLAVGLMLPHFIGCEKPEKRELKLCGRDFIDKLLETCASLKARMYHPYDSFQPPAGNNGMEGRIYTKMDPRGSYNAPQPFYNGYNIYGQVPGDFHEFALGADRDAKSPRARTSPHSKLKRRQLESKCCEVGCTREELIQRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFN1</accession>
    <name>A0A401PFN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4209 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002005">
        <property type="protein sequence ID" value="GCB71942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFN1"/>
    <dbReference type="STRING" id="75743.A0A401PFN1"/>
    <dbReference type="OMA" id="GCFIAND"/>
    <dbReference type="OrthoDB" id="49386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025209">
        <property type="entry name" value="DUF4209"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039635">
        <property type="entry name" value="ERMARD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701:SF2">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13910">
        <property type="entry name" value="DUF4209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4209" evidence="1">
        <location>
            <begin position="115"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="651" mass="74210" checksum="0E60488AC8C63F24" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIB9</accession>
    <name>A0A401PIB9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0006510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002206">
        <property type="protein sequence ID" value="GCB72876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIB9"/>
    <dbReference type="STRING" id="75743.A0A401PIB9"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF6">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="282"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="695"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB72876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="819" mass="94852" checksum="3196D5C8F88F62D0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIQ3</accession>
    <name>A0A401PIQ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002239">
        <property type="protein sequence ID" value="GCB73007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIQ3"/>
    <dbReference type="STRING" id="75743.A0A401PIQ3"/>
    <dbReference type="OMA" id="MIFGPQK"/>
    <dbReference type="OrthoDB" id="9924021at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10344">
        <property type="entry name" value="SH2_SLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035052">
        <property type="entry name" value="SLAP_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="91"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB73007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33632" checksum="66B7139A2F145958" modified="2019-05-08" version="1">MGSRPSKSRRQTMTVIPSDPVNQLATDISKVMMVVALYNYPSSSDSEPVIRVGEKLSVISEEGDWWKVMSMTTGKECHIPCNYVAKVYHRWLFEGISREKAEELLLLPSNRSGAFMIRESQTRKGSYSLSIRRSNNASWDSIKHYRINRLPNGWFYISPRLTVPSLHDMVDYYSESGEGLCCTLKEPCHIQGPPVAQRHHPDPVMVQKPQLNWNEMDSSVLINDNKDLGEESPVSTGLREAINSYLFMTEEMGLDQMKDKKTRLKMLQARLQNSQRHANLNVVGTLGHLNFNSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIS1</accession>
    <name>A0A401PIS1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002246">
        <property type="protein sequence ID" value="GCB73026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIS1"/>
    <dbReference type="STRING" id="75743.A0A401PIS1"/>
    <dbReference type="OMA" id="EAYGHVF"/>
    <dbReference type="OrthoDB" id="9940999at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000509">
        <property type="entry name" value="Immunoglobin superfamily member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF121">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019122355" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB73026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="342" mass="38583" checksum="205004AECC3E08E6" modified="2019-05-08" version="1">MNRKSAYFHLSFLLHHLVDITLGYLTVNIEPISPVVAGDAVTLKCNFKTDGRLREIVWYKVTDGGTIKQKIFTYDALFSTNYTHIDEYQKREDLVYQSTVRIPEVRILDNGPFECHVGIYDRTNRKKFLEAYGHVFLNVMSPPSSISVIAADAPAAFSRYEAQNFTLVCIVSGGKPAPTVYFKRDGELVEVLHVSQTSSDAGMRKTRVPQNLISRDMDDTKMQKSLSLLDFEGGGRLFTERPSQSITDSAASATTEAERIPETVISREFPRWIYPSDPEYLFRHTQIPVSDGTVEVRAMITWTLNPDLDNNALFSCEVKHPALSMPMQSEVVLGKSEKLTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIS4</accession>
    <name>A0A401PIS4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin-binding LIM protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000570">
        <property type="protein sequence ID" value="GCB73025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIS4"/>
    <dbReference type="STRING" id="75743.A0A401PIS4"/>
    <dbReference type="OMA" id="NNHFHIQ"/>
    <dbReference type="OrthoDB" id="1746725at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09327">
        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09328">
        <property type="entry name" value="LIM2_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000003">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000004">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000007">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000024">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.950.10:FF:000001">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF0">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HP" evidence="11">
        <location>
            <begin position="573"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB73025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="72871" checksum="0E0326681628D1C8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIT3</accession>
    <name>A0A401PIT3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0002301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB73011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10072451at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="GTF2I-like"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004212">
        <property type="entry name" value="GTF2I"/>
    </dbReference>
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        <property type="entry name" value="GTF2I-like_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46304">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02946">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117773">
        <property type="entry name" value="GTF2I-like repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="8">
        <location>
            <begin position="409"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1326"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1510"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1554"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1341"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1567"/>
            <end position="1577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB73011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1577" mass="177027" checksum="BC911637A5A6CBF3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJQ4</accession>
    <name>A0A401PJQ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0002490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000627">
        <property type="protein sequence ID" value="GCB73345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJQ4"/>
    <dbReference type="STRING" id="75743.A0A401PJQ4"/>
    <dbReference type="OMA" id="LSFTLEX"/>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01234">
        <property type="entry name" value="PH_CADPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000007">
        <property type="entry name" value="Calcium-dependent secretion activator 2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF7">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="87"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="225"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="15">
        <location>
            <begin position="621"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB73345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="931" mass="106701" checksum="91E4002BBA5A237D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJR2</accession>
    <name>A0A401PJR2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0006731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM118 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002320">
        <property type="protein sequence ID" value="GCB73346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJR2"/>
    <dbReference type="STRING" id="75743.A0A401PJR2"/>
    <dbReference type="OMA" id="YRDVTQD"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038916">
        <property type="entry name" value="FAM118"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28623:SF2">
        <property type="entry name" value="PROTEIN FAM118A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28623">
        <property type="entry name" value="PROTEIN FAM118B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB73346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="361" mass="41317" checksum="F2A1721920E0F8CF" modified="2019-05-08" version="1">MQVHMDLVNPSRTLEQKSRKFLKSLTRKEPCELLLVIGTGVSAAVAPHIPALCSWRSCIEAVINAAEDLEVLHPSDIMEFRHKVTEDRDLLVLAHDLIRKMSPRTGDTKPNFFQDCLMEVFDNLNCQIQNPMLLHAILQLMDRGTMVLTTNYDNLLEIFGQQQGKPMESVDLKCKDKVVQWARGLQKYSVLHIHGLFTDPCGLVLDPSGYKDVMHDQDLMEEFQDLYRTKSFVFLGCGETLRDQIFQALFLYSVQDKVDLEHFMLVRKDSHDQFFKLQAEMLLHGIKIVSYGDRFECMPQYFHDLVTQICRHRSPDGSSADSTSLLLGSSCSDCAKRKQEENGDVTQKRIRKANDTDFEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJW2</accession>
    <name>A0A401PJW2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002339">
        <property type="protein sequence ID" value="GCB73429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJW2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB73429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="77" mass="8007" checksum="428273B11F7376C6" modified="2019-05-08" version="1">MVEVNNALERMAFDGVVEVSGFDVAEDSGFGAAEDSGFGVAEDSGFGAAEDSGFDAAVELLKREALDPEEPDTGEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKJ0</accession>
    <name>A0A401PKJ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat and sterile alpha motif domain-containing protein 1B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0002739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000704">
        <property type="protein sequence ID" value="GCB73659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKJ0"/>
    <dbReference type="STRING" id="75743.A0A401PKJ0"/>
    <dbReference type="OMA" id="DKHYCHV"/>
    <dbReference type="OrthoDB" id="10039052at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01274">
        <property type="entry name" value="PTB_Anks"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09500">
        <property type="entry name" value="SAM_AIDA1AB-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000045">
        <property type="entry name" value="Ankyrin repeat and sterile alpha motif domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041882">
        <property type="entry name" value="SAM_ANKS1_repeat2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF3">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="218"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB73659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47046" checksum="B9E8241CE4A4D256" modified="2019-05-08" version="1">MGSNVVEDQDLLEIGILNSSHRQRILQAVRGLPRVKVIGYDTNSPTSVADWLDSLELNDYIKTFLANGYTSMDLVKKLWEIELINVLKINLLGHRKRILASLGDRLHDEPPQKPPRTITLRDPGNNTPPQLSPSLSQSTYTGGSLDIPSSHLMMQGDARRRINDSYFEDMPRSKLERQMAQQAEWSEPSITLRPPNEATSSTPVQYWQHHPEKLIFQSCDYEAYYLGSMLVKELRGTESTQDACSKMRASEQMKKIPTIILSISYKGVKFIDAANKNIITEHEIRNISCAAQDPEDLSTFAYITKDLKSSYHYCHVFSAFDVNLAYEIILTLGQAFEVAYQLALQARKGSHGPPTMQDSLESKAGKPIPKPRASIRKSVIDQPLLEQKTHPNVPWIVEPVQESKRAMSTKYETTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLB8</accession>
    <name>A0A401PLB8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0002999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000785">
        <property type="protein sequence ID" value="GCB73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLB8"/>
    <dbReference type="STRING" id="75743.A0A401PLB8"/>
    <dbReference type="OMA" id="PAMCEAG"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000202">
        <property type="entry name" value="Dual specificity testis-specific protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="272" mass="30871" checksum="715EB43B2475A215" modified="2019-05-08" version="1">MESGGGWLEDGAFNGQLVTHNTTHKVMVVKIHKQDVDQEAIVREISLLQKLSHPNIVRYLGVCVKEDKLYPMLEYINGGSLEELLANKEENLTWKEKVDLASDITRGMAYLHSKNIYHRDLNSKNCLIRITSRGREALVTDFGLAREVVELPTKDLERKLSLVGSAFWMAPEMLRGEPYDRKVDVFSFGIVLCEILGRVTADPEFLPRTQDYGLNAEAFKEMVNGCPKRVLELTVNCCKIDAFKRPSFTELLDQLEEVAESLEPNKDNQITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMB4</accession>
    <name>A0A401PMB4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0003373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000909">
        <property type="protein sequence ID" value="GCB74284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMB4"/>
    <dbReference type="STRING" id="75743.A0A401PMB4"/>
    <dbReference type="OMA" id="CIMFVLF"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000848">
        <property type="entry name" value="GPCR_cAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF47">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00247">
        <property type="entry name" value="GPCRCAMP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB74284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37349" checksum="DD16D9F7EA588F81" modified="2019-05-08" version="1">MLTVPQTEVYTYEKVVIFISCCLSFLGASLIIGGHFWWPDLRTRARQLLLYLSLADLLSALSYSYGVLRDFQSSTWDCVLQGALSTFANTSSFFWTVAIAVYLYLIIVRSEKALADSLVVWFHAISWLVPLVITVAAVSLQKIGYDASDVSVGWCWVSIQADDHVLWMLLTGKIWEFIAYITLPTLYILIKKHIYKAHEALSEYRPILASSSRHHTQSSIADRKLTIIPIIFIFLRIWSTVRFILTLCNSPAVQNGMLVILHGVGNTFQGAANCIIFVLCTQVVRTRLVSCLCSCFRHNVDPAPHKGLVNNYGEVISRRNAEMIPSYVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMW5</accession>
    <name>A0A401PMW5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/potassium-transporting ATPase subunit beta-1-interacting protein</fullName>
            <shortName evidence="7">Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0003535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NKAIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000972">
        <property type="protein sequence ID" value="GCB74445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMW5"/>
    <dbReference type="OMA" id="XLVGFVY"/>
    <dbReference type="OrthoDB" id="10050321at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008516">
        <property type="entry name" value="Na/K-Atpase_Interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084:SF6">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084">
        <property type="entry name" value="T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05640">
        <property type="entry name" value="NKAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019247380" description="Sodium/potassium-transporting ATPase subunit beta-1-interacting protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB74445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="109" mass="12693" checksum="51E4D6272ABE590F" modified="2019-05-08" version="1">MGCCTGRCTLIFLCTLQLLAALERQIFDFLGYQWAPILANFLHIIVVILGLFGTIQYRPRYIMVYSIWTALWVAWNVFIFCFYLEVGGLSKVRTSFENFHHVENQMSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPG4</accession>
    <name>A0A401PPG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0020849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017475">
        <property type="protein sequence ID" value="GCB74941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPG4"/>
    <dbReference type="STRING" id="75743.A0A401PPG4"/>
    <dbReference type="OMA" id="RSMDVTF"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000242">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB74941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="124" mass="13744" checksum="64732F894F860653" modified="2019-05-08" version="1" fragment="single">TEAMADDSEEERTKMEAVRGQTAAAKNLAFLKARSMDVTFDVGEEYEIIETIGTGAYGVVSSARQRQTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKLPGSFADFKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPM3</accession>
    <name>A0A401PPM3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0017293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011123">
        <property type="protein sequence ID" value="GCB75096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPM3"/>
    <dbReference type="STRING" id="75743.A0A401PPM3"/>
    <dbReference type="OMA" id="FCILCLH"/>
    <dbReference type="OrthoDB" id="9984940at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20365">
        <property type="entry name" value="BRcat_RBR_FBXO43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000006">
        <property type="entry name" value="F-box only protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044064">
        <property type="entry name" value="ZF_ZBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51872">
        <property type="entry name" value="ZF_ZBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZBR-type" evidence="7">
        <location>
            <begin position="606"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB75096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="678" mass="75658" checksum="4C437DC4018846DE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQX9</accession>
    <name>A0A401PQX9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0015334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008658">
        <property type="protein sequence ID" value="GCB75528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQX9"/>
    <dbReference type="STRING" id="75743.A0A401PQX9"/>
    <dbReference type="OMA" id="NDKEMNC"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18947">
        <property type="entry name" value="bHLH-PAS_ARNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000011">
        <property type="entry name" value="Aryl hydrocarbon receptor nuclear translocator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB75528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20085" checksum="6724AD121C92C3D3" modified="2019-05-08" version="1">MNINCNQLLNQKQQLEFDDEDGEGPSKFSRENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGAYKPSFLTEKELKHLILEAADGFLFVAGAETGRIIYVSDSVTPVLNHPQAEWFGSTLYEQVHPDDVEKLREQLSTSESSMTGKRFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR07</accession>
    <name>A0A401PR07_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01009930">
        <property type="protein sequence ID" value="GCB75558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR07"/>
    <dbReference type="STRING" id="75743.A0A401PR07"/>
    <dbReference type="OMA" id="THECAAI"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000278">
        <property type="entry name" value="Protein CBG07490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB75558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="157" mass="17946" checksum="C91542633C1E2180" modified="2019-05-08" version="1">MGSQSVCGDIHGQFFDLMKLFEVGGSPASTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERIYDACMDAFDCLPLAALMNQQFLCVHGGLSPEVNTLDDIKKRPRTVKKATSPVTGSSSYRSDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR21</accession>
    <name>A0A401PR21_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011214">
        <property type="protein sequence ID" value="GCB75579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR21"/>
    <dbReference type="STRING" id="75743.A0A401PR21"/>
    <dbReference type="OMA" id="GTTQWQT"/>
    <dbReference type="OrthoDB" id="5969782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000003">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000143">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF10">
        <property type="entry name" value="AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="243" mass="26967" checksum="DFBC3EDCC183AF52" modified="2019-05-08" version="1">MNVSGLGREIEADCRAEEDSQYPLQQITRFQISWRVFENNLWSDQSLEIDPDLPPGWRTIRDTSGTYYWHVPTGTTQWQHPACISDISLGSEKLSAALEHKAVAPDAATVNRISGGGKFANSMPSSSSINLRTELPWQDSSLQLNSDPDSKCFAVRSLGWVEIPEEDLTPGKSSIAVNNCIQQLSYSKSEGRQRGLAWGEGQDMVMVLRKDTLSLVDPVDHSLIHSQPIINIRVWGVGCNNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR34</accession>
    <name>A0A401PR34_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4503 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008663">
        <property type="protein sequence ID" value="GCB75557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR34"/>
    <dbReference type="STRING" id="75743.A0A401PR34"/>
    <dbReference type="OMA" id="GHGQACE"/>
    <dbReference type="OrthoDB" id="1914453at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070202">
        <property type="term" value="P:regulation of establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053054">
        <property type="entry name" value="DNA_repair-scaffolding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028032">
        <property type="entry name" value="DUF4503"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34347:SF1">
        <property type="entry name" value="DNA REPAIR-SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34347">
        <property type="entry name" value="DNA REPAIR-SCAFFOLDING PROTEIN SPIDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14951">
        <property type="entry name" value="DUF4503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4503" evidence="1">
        <location>
            <begin position="5"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="354" mass="39072" checksum="EF9ACD445077F7D8" modified="2019-05-08" version="1">MLSLRSSGLFSLIDSLWPPLIPPKVHGQSQGSQEHVDLSTDMFLPAPSFCYILTPLPGEGGVDVLQNESVSDLYQPSTLHDLKHICQHVPERHRCSFSAEVIYRRLQGQPANLQMNKDFWLCVTDSTLQSASHDSEVPRTISVCVTLFCVLGTNVIKSLNDEASSNISFKNAIVEKDSIVCAEGTVLSVQKSMLRSNENQEISPLNGNFILDKLSAKTKLNSLCTVQGTVVGVDESTAFSWIVCNRCENGKLEKKHGEGELLYCRQCAQSVMTPLTKMQLEVFLQYPVLPHSTVKIKLQEQSILSLLLHSSSDEGGYEMSSVLGQELGPLSCYVRSVTNQPASWIGLEEIRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRT9</accession>
    <name>A0A401PRT9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017725">
        <property type="protein sequence ID" value="GCB75838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRT9"/>
    <dbReference type="STRING" id="75743.A0A401PRT9"/>
    <dbReference type="OrthoDB" id="10061772at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14805" checksum="42D43677E216212A" modified="2019-05-08" version="1" fragment="single">DTSCSIVISNEPLLRSKPIIFNPDFFVEKLRHEKPEVFLELVVSNLTRLIDLPGTEFAQLIGEEEPSLPSTTSSSFFRSFNFLKRKEKGVVFGAPLTEEGIAQIYQLIEHLYKTQEEAIQPIVSPPAPKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSE1</accession>
    <name>A0A401PSE1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011294">
        <property type="protein sequence ID" value="GCB76013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSE1"/>
    <dbReference type="STRING" id="75743.A0A401PSE1"/>
    <dbReference type="OrthoDB" id="8949702at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="12544" checksum="9ADD5F27308BFF74" modified="2019-05-08" version="1">MVGSVSLSFGLIRGATSNPTQPAPTTFFFGGNPLIRGEGAGILWTREFGFPFPLSTMAFAIFRTVLALFHITQVLGFGVDPALEIDVFSALQLSDSTEGIAQVQGFHNGSRAFLFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSG5</accession>
    <name>A0A401PSG5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017773">
        <property type="protein sequence ID" value="GCB76047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSG5"/>
    <dbReference type="OrthoDB" id="10043646at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="44" mass="5050" checksum="2D6048692A92E20E" modified="2019-05-08" version="1" fragment="single">MEGYLITPYPEDIGAYDSDVCRQQHEYYTYLPSSDGESQSGIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSI1</accession>
    <name>A0A401PSI1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0018298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01012598">
        <property type="protein sequence ID" value="GCB76062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSI1"/>
    <dbReference type="STRING" id="75743.A0A401PSI1"/>
    <dbReference type="OMA" id="NFHWQAT"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB76062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16729" checksum="481DA53418E58DDD" modified="2019-05-08" version="1">MAKRRIEKELKDLQRDPPAQCSAGPAGDDMFVWQATIMGPYDSPYQGGVFFLAIQFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIAHMYKTDKEKYNKQARDWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSU1</accession>
    <name>A0A401PSU1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ankyrin repeat and LEM domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">LEM domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0016530</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ANKLE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010036">
        <property type="protein sequence ID" value="GCB76204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PSU1"/>
    <dbReference type="OrthoDB" id="7446186at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000072">
        <property type="entry name" value="Ankyrin repeat and LEM domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.40:FF:000001">
        <property type="entry name" value="LEM domain containing 2, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056237">
        <property type="entry name" value="ANKLE2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24567">
        <property type="entry name" value="ANKLE2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LEM" evidence="19">
        <location>
            <begin position="1128"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1093"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1172"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1222"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="227"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="766"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1042"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1093"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1172"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1188"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1234"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1244"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB76204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1989" mass="224623" checksum="76C45D29275279C1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTG5</accession>
    <name>A0A401PTG5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Carcharhiniformes</taxon>
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            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012677">
        <property type="protein sequence ID" value="GCB76421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTG5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="54" mass="6148" checksum="A3CB99D1137FF376" modified="2019-05-08" version="1" fragment="single">SWSRLEAQKGIFEPMVEIPVLREQLNHHRVASESARSELAALQVKYKSSQAEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTK1</accession>
    <name>A0A401PTK1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016584">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="134" mass="17292" checksum="086F67D4812575A7" modified="2019-05-08" version="1">MYIEYDMEMYIEYYVEMYIEYYVEMYIEYYVEMYIEYFVEMYIEYDMEMYIEYYVEMYIEYSVEMYIEYYVEMYIEYYVEMYIEYYVKMYIEYYVEMYIEYYGIKTMLTLSMYLWGIIILGLLPNTIKAGNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTZ7</accession>
    <name>A0A401PTZ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OCIA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015315">
        <property type="protein sequence ID" value="GCB76619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTZ7"/>
    <dbReference type="STRING" id="75743.A0A401PTZ7"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14725" checksum="49E6458D2B2DDCFF" modified="2019-05-08" version="1">MQPSIGAPSMVDGDTDFSLFWMNHWFCCNLMVPFFLVFSLPWSVHLPLLTPCCSRPSIRRFSSYHRILQMIAFGIASRVRPLHLLVATSGGYVGYCQYHKYKLRELEHSGIEDLVQKSLASEWQVSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVF7</accession>
    <name>A0A401PVF7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division cycle and apoptosis regulator protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0018419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012809">
        <property type="protein sequence ID" value="GCB77053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVF7"/>
    <dbReference type="STRING" id="75743.A0A401PVF7"/>
    <dbReference type="OrthoDB" id="21006at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000006">
        <property type="entry name" value="Cell division cycle and apoptosis regulator protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025224">
        <property type="entry name" value="CCAR1/CCAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025954">
        <property type="entry name" value="DBC1/CARP1_inactive_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045353">
        <property type="entry name" value="LAIKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304:SF14">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14443">
        <property type="entry name" value="DBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19256">
        <property type="entry name" value="LAIKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01122">
        <property type="entry name" value="DBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="9">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB77053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="472" mass="54603" checksum="382145E86D57D83C" modified="2019-05-08" version="1" fragment="single">FLVGMKGKDEAMAIGGHWSPSLDGPNPETDPSVLIRTAIRCCKALTSIDLSGCTQWYRFAEIRYHRPEEHHKGRTVPAHVETVVIFLPDVWHCLPTRSEWEALSRGYKQQLVEKLQAEHKEADGEQEEEEKDDGESKEISTPTHWSKLDPKTLKVNDLRKELESRNQSSKGLKSQLIARLTKQLKTEAEKEEQKESEKSEREDDEEEDKRSEDEKEEEERKRQEEVERQRRERRYILPDESSIIVHPNWTAKGGKFDCSVMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGYRVYKALVTLPDKDDKKEKDKKDRKEEKKESEKREKKEEKYEDSNEPKAKRRKSGDEKDKKEERDGRKKEEKDKDDKNLRKRDDSKEDEEMEDGGNQDDYDPLDADGAEDEDDEGKTSRNVDGSVALACSFGSLRMGKGENQMGILFLITTPLPLLESGRIGLGSAGMFPTADQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVX8</accession>
    <name>A0A401PVX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="4">PARP</shortName>
            <ecNumber evidence="4">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0019983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01015471">
        <property type="protein sequence ID" value="GCB77286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVX8"/>
    <dbReference type="STRING" id="75743.A0A401PVX8"/>
    <dbReference type="OMA" id="STGHHQY"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF6">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23466">
        <property type="entry name" value="WWE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WWE" evidence="5">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="183"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB77286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="398" mass="46513" checksum="DCE5C3F293639916" modified="2019-05-08" version="1" fragment="single">SDKCKLVHFKLPYRWQVDEDGWKDLPDMEQIEKDYCDPYCTDRAGLPAVNFRTMTNNLNRVRRLSTTSSVTKPPHYTLTTEWLWYWQADTGMWIEYGKQQGLETVTSTDLENLYLADSKEKAVFLMGTCQYTVDFEAMNQRNTILGTCREVRRRPRFVAEQEMERRMYRNVPVKEDPPQNKATPTHWEMSAQPTNGYKLVLVPESSVEYKRVQSLFQRTMRNSVIRKIERIQNLALWEIFQWQKEQMNKKNGGKEVDERQLFYGWDSSPIATVCVENFDWRTCGMHGEGFGKGSYFARDASYADNYFSTTSATKTMFLARVLVGQFFKGRADYCRPPSKDATYTNLYDSCTDNGANPSIFVIFEKHQIYPEYIIEYSNKVGFFQWMMGVMSGRSASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWK1</accession>
    <name>A0A401PWK1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">REC114 meiotic recombination protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011590">
        <property type="protein sequence ID" value="GCB77507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWK1"/>
    <dbReference type="STRING" id="75743.A0A401PWK1"/>
    <dbReference type="OMA" id="RYGRFML"/>
    <dbReference type="OrthoDB" id="6479200at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029168">
        <property type="entry name" value="REC114L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34921">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34921:SF1">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15165">
        <property type="entry name" value="REC114-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20149" checksum="31B87538B29AC438" modified="2019-05-08" version="1">MSGSRLVFESNPEKGVLSLMVVQSGHFLISQGGATLLEGFSLIDAHKWCKAVRRADCVLFGSKVKNESRMFRVQFSGDSHRQALEGCSTCVQMLLQYIDVQNPDGKVQNQALQLSQPTNVSLSGSLELESMLGATSPKLPLAYQQSTLNAEELGPFLRLCLLDQGFPEFVEQVEQELKKLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWS6</accession>
    <name>A0A401PWS6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC NOA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0020007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015543">
        <property type="protein sequence ID" value="GCB77580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWS6"/>
    <dbReference type="OMA" id="PTERSNQ"/>
    <dbReference type="OrthoDB" id="6066489at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034134">
        <property type="term" value="P:toll-like receptor 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034138">
        <property type="term" value="P:toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022008">
        <property type="entry name" value="EABR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034735">
        <property type="entry name" value="NEMO_ZF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882:SF6">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12180">
        <property type="entry name" value="EABR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51801">
        <property type="entry name" value="ZF_CCHC_NOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC NOA-type" evidence="9">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="207"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB77580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="364" mass="42461" checksum="42E5D720139A7E41" modified="2019-05-08" version="1" fragment="single">DLQAVELRLKEKEREVEQIVGSPQHEKDGEIARLRHALQEKDRFHATRELWCRSLAGETEKLQQRLASTADMCQQLSRQLEEQRAKNGHGVEKELCATKQNVKLHQADSPETNLYKLQEENRTLKQKVVYVEDLNTKWQKYDVSREEYVKNLHQQLKDLKSRVDRLTGLGPSQANENVLRQEILRLNRLLEEKMKDCSRLANYRDGRGKERATIQQLRDDLQVAQEAASAARERMQMLEQQVLVYKDDFQSEREDRERAQSRIQELEEDLARLRLQLPRKQEHRESAALHHDRVSPYYMETDIPAPLLGNGTDPLVEVSRPLLPSGSPGVEIRQQGLLQCPKCMRLFNDEVSDECLRHISECCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY38</accession>
    <name>A0A401PY38_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA non-specific endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0018552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013037">
        <property type="protein sequence ID" value="GCB78067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY38"/>
    <dbReference type="STRING" id="75743.A0A401PY38"/>
    <dbReference type="OMA" id="NITNICS"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041003">
        <property type="entry name" value="Exog_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF19">
        <property type="entry name" value="NUCLEASE EXOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18026">
        <property type="entry name" value="Exog_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EXOG C-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17021" checksum="A826B505FF73C31B" modified="2019-05-08" version="1" fragment="single">VIGKNEVAVPTHLYKVILAQKSSAPSALLALGAFVVPNRPIGFDHQLPEYQVDLRDLEKMSGITFFPALDKSRQCRDLCATDTCKLLSFAEFNRYIAGRNVQNAKTLHTLEKVMAKLQESGIEPDEYLQNLYQKKKQEVEVKEAGEGRAAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYM3</accession>
    <name>A0A401PYM3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0020082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="BFAA01015706">
        <property type="protein sequence ID" value="GCB78235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYM3"/>
    <dbReference type="STRING" id="75743.A0A401PYM3"/>
    <dbReference type="OMA" id="ERTMEFR"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF59">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB78235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="291" mass="32396" checksum="66F35EA5011B9C91" modified="2019-05-08" version="1">MAGAIGNSGIWESHTAMLVEPLSSNDPEVYGIIKKEKSRQRLGLELIASENFASRAVLEALGSCMNNKYSEGYPGQRYYGGTEFVDELERLCQKRALDLYSLDAQKWGVNVQPYSGSPANFAIYTALVEPHGRIMGLDLPDGGHLTHGFMTEKKKISATSIFFESMPYKVNPETGYIDYDRLAENARLFHPKLIIAGISCYSRNLDYARMRQIADENSAYLMADMAHISGLVAAGVVPSPFEYSDVVSTTTHKTLRGCRSGMIFYRKGEGKMFGWTVSQSHLLSKTLFLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYZ4</accession>
    <name>A0A401PYZ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOP1-like TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018316">
        <property type="protein sequence ID" value="GCB78263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYZ4"/>
    <dbReference type="STRING" id="75743.A0A401PYZ4"/>
    <dbReference type="OMA" id="HSHICEE"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF22">
        <property type="entry name" value="PROTEIN DOPEY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOP1-like TPR" evidence="2">
        <location>
            <begin position="409"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="803" mass="88989" checksum="1B452714B8DE66B1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q038</accession>
    <name>A0A401Q038_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010498">
        <property type="protein sequence ID" value="GCB78728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q038"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7704" checksum="9C58A5B692B9D38E" modified="2019-05-08" version="1">MSPRDYFSVKIKENLSLKKRSVSLYCTRLVDRRKLQKSPLCIKEGETSELSSTATTILKDSVIVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2I5</accession>
    <name>A0A401Q2I5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012024">
        <property type="protein sequence ID" value="GCB79554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2I5"/>
    <dbReference type="OMA" id="LVWINND"/>
    <dbReference type="OrthoDB" id="9937043at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11422:SF10">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11422">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="115"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="329"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB79554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="489" mass="56232" checksum="682F4829A2D00F18" modified="2019-05-08" version="1">MFSFFVFLLPPSFTERNPNHHYFVAKRGAASLKGPDNPGDGSFLWEWKPHSGQEIQQMVTFQKKYWRSWNAEWSEYFIKNKLYQWIDRDRDTINLRIENPTFKFSGLFTLFQTQPSKKLLKQHEIFGVQVESSPQWPPLGSDVTLSCTISRLSDTVSLHWKQRDSSQLNRRKTDQIRINNTVYLTVKHVPGEDARLYVCEVKENGFITLTVKVDFSISQYLHNIKYTLYRSSTNHSELDLICGVISEYNKTKWTWSSRYFQKQEKEIASTYKSQPINVKRADFGDRLVPTETNANGTNFRVRIVPVLFEDAGVYTCSLGTSKMVTITLITVKVTAEPSDAVSEGDTVNLTCSVSDVTESMTLAWISSDGKTVVEKTLNGQNGEEKSLRLIIQKAERGSRNWTCVLFHQRTPKIFIPHYLKVNMRARTFPDIWIITVSGYLFVKLGFAVGLIFSLKRMDRMSKTGNSHKMTGNEEAVQLKTLNSDIDLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q485</accession>
    <name>A0A401Q485_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012193">
        <property type="protein sequence ID" value="GCB80161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q485"/>
    <dbReference type="STRING" id="75743.A0A401Q485"/>
    <dbReference type="OMA" id="ITIFWTC"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF3">
        <property type="entry name" value="FORMIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="12529" checksum="A3137EDAACEACFB7" modified="2019-05-08" version="1" fragment="single">NSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLKSYLDPGVTRKKFRRRVQESTKVLRELEISLRTNYIGWVREFLNDENQGLNVLVDYLSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q509</accession>
    <name>A0A401Q509_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1. Interacts with RAB5C. Interacts with STX17, MON1B. Associates with adapter protein complex 3 (AP-3) and clathrin:AP-3 complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010953">
        <property type="protein sequence ID" value="GCB80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q509"/>
    <dbReference type="STRING" id="75743.A0A401Q509"/>
    <dbReference type="OMA" id="WCGDDCL"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.780:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="248"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="466"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="788" mass="90127" checksum="1B4119674FA194E6" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5B7</accession>
    <name>A0A401Q5B7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009714">
        <property type="protein sequence ID" value="GCB80570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5B7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8480" checksum="9AD0C1730C07928F" modified="2019-05-08" version="1">MAWRITKSRDLDPWPSPDGNIQDIQYMQKSFVVDVSLKREEVENGTLPHGGKLNVKTCSFRPAKNIPSMCLIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5Q3</accession>
    <name>A0A401Q5Q3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009844">
        <property type="protein sequence ID" value="GCB80719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5Q3"/>
    <dbReference type="STRING" id="75743.A0A401Q5Q3"/>
    <dbReference type="OMA" id="MITINRM"/>
    <dbReference type="OrthoDB" id="2126778at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000015">
        <property type="entry name" value="Islet cell autoantigen 1, 69kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006723">
        <property type="entry name" value="Islet_autoAg_Ica1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF5">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04629">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="255" mass="29724" checksum="CE4F54485819CDE9" modified="2019-05-08" version="1" fragment="single">MDKVFHIIQTSCIDLLKVIEKYQLRLNILSQEENELGMFLRGQSEQDKTPAGRMMNATSKALCGSAKQRLALRVPLFRLEQEVETFRRRAVSDTLLTVNRMEQSRTEYRGALLWMKDVSQELDPDTYKQMEKFRKVQAQVRNTKVHFDKLKNDVCQKVDLLGASRCNLLSQSLAAYQNTLLHFWERTAHMMSQIHESFKGHQPYKFTTLKSLQDPFHHLTEEEFNQSKEKEKECITDDIDKLVLLDEDEEPGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q604</accession>
    <name>A0A401Q604_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027563">
        <property type="protein sequence ID" value="GCB80814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q604"/>
    <dbReference type="OrthoDB" id="9445109at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPAR/Ly6" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="10704" checksum="EAE4285CAF571896" modified="2019-05-08" version="1">MLGDFKCNRSGPIPCEGSQTKCGSLEGFIENGSRHFDFRGCVSESICSLNSTEVIFGIDLQKRFQCCDGNLCNRSSRTETGALGLIVLCLCLLIFNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7Y9</accession>
    <name>A0A401Q7Y9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0021396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018899">
        <property type="protein sequence ID" value="GCB81447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7Y9"/>
    <dbReference type="STRING" id="75743.A0A401Q7Y9"/>
    <dbReference type="OMA" id="DICIEDS"/>
    <dbReference type="OrthoDB" id="9355041at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000211">
        <property type="entry name" value="Obscurin-like protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052385">
        <property type="entry name" value="Obscurin/Obscurin-like_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35971:SF5">
        <property type="entry name" value="OBSCURIN LIKE CYTOSKELETAL ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35971">
        <property type="entry name" value="SI:DKEY-31G6.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="94"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="182"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB81447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="360" mass="40177" checksum="BA0BA5FBBA41D2C6" modified="2019-05-08" version="1" fragment="single">TLVLFTNKEKLPEEVHANENGKAVLAAIVSKENASVAWYRHREEVPEGGKYERKGESRVHSLIVKNVQREDCGMYTCRSADDEMFFNVNMAELPLQFMLKLEDLSVQKGGAVTLWCELNKVKGDVMWLKDGKEVQPSGQRVVRAEGRLRSLTLTKAALEDQGEYSCECKDDKTTAQVSVRVPRVVEFISDLHSVAVLEGDDAKFKCMVSPEDVRLTWQAGGAEIPPGSDKYVASRNGLCHTLLIRSCQLTEAGRVTAEAEGVVSGANLQVQETQIVFTRKMASMVAEELQDTTFEVEVSSEAAEVQWMKQGVVIQPCPKFLLQQEGRTRRLIVCSTAFADRGNYRCETLHDRTQAKLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q856</accession>
    <name>A0A401Q856_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0021856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020267">
        <property type="protein sequence ID" value="GCB81558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q856"/>
    <dbReference type="STRING" id="75743.A0A401Q856"/>
    <dbReference type="OMA" id="PAIEGIW"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB81558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="8825" checksum="E012A8FE48C06013" modified="2019-05-08" version="1" fragment="single">VLAQNSGYDPQETLVKIQTEYSASGQLLGVNLNTGEPMLAGETGVWDNYNVKKQLLHSCTVIASNILLVDEIMRAGMSSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q889</accession>
    <name>A0A401Q889_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020253">
        <property type="protein sequence ID" value="GCB81537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q889"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="10835" checksum="0CE0CE7919278F21" modified="2019-05-08" version="1">MEQILGYVERIEGNVVQIQANVERIQENVEWIEGNLEQVQGNVEQGQGNVEQIQGNMELIQANVERMQENVEQGQECGADAAEYGAETTGTIQPKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9Y4</accession>
    <name>A0A401Q9Y4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4706 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020647">
        <property type="protein sequence ID" value="GCB82193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9Y4"/>
    <dbReference type="STRING" id="75743.A0A401Q9Y4"/>
    <dbReference type="OrthoDB" id="5984457at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031600">
        <property type="entry name" value="DUF4706"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34394">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2310022B05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34394:SF1">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2310022B05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15797">
        <property type="entry name" value="DUF4706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4706" evidence="1">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="12800" checksum="2747457168EFABB1" modified="2019-05-08" version="1">MVMSCEVGEAMVAAAGLEQKKFDYFASISPMARRIMLERQKIREKYGPRWERLEPREQEEIIDNWMVEPQIRSRYNLHRNQKEETVSYPRLQLQTGQKVVHFGEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBD3</accession>
    <name>A0A401QBD3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2'-5'-oligoadenylate synthetase 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-5A synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019717">
        <property type="protein sequence ID" value="GCB82691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBD3"/>
    <dbReference type="STRING" id="75743.A0A401QBD3"/>
    <dbReference type="OMA" id="NTIFRTE"/>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001730">
        <property type="term" value="F:2'-5'-oligoadenylate synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.20">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018952">
        <property type="entry name" value="2-5-oligoAdlate_synth_1_dom2/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043518">
        <property type="entry name" value="2-5OAS_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258:SF7">
        <property type="entry name" value="2'-5'-OLIGOADENYLATE SYNTHASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258">
        <property type="entry name" value="2-5 OLIGOADENYLATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10421">
        <property type="entry name" value="OAS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00832">
        <property type="entry name" value="25A_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2'-5'-oligoadenylate synthetase 1" evidence="2">
        <location>
            <begin position="107"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="240" mass="27665" checksum="7FE1EAC6A3D0B43D" modified="2019-05-08" version="1" fragment="single">GGSSGKGTALRIGSDADLVVFLSCFNSFQDQRNTRQEILEGIQQTLKVCAQSIAHDISDITITFPPNRDIPPKSMSFTLKSRKSSDSVDFDILPTFDALKGTENTTEAHLKLIDLVRKNGDLNGEFSACFTELQRNFVKQYEPKLKDLIRLLKYWYKQYVRKSELRPGERLPAKYAVELLTIYAWEQGNGKERFSTAEGLRTVLELICKYQHLCIYWTKYYNVNDRVIADFLMKKLRDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBH3</accession>
    <name>A0A401QBH3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0021714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019817">
        <property type="protein sequence ID" value="GCB82731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBH3"/>
    <dbReference type="STRING" id="75743.A0A401QBH3"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB82731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="167" mass="18102" checksum="2C17A4CA180F72AA" modified="2019-05-08" version="1">MSGHGISANGLAYCLWVLSTSDSLDSCQGKSSCPVISLTIRPDIRMKCGQNYVYVFDGIPEFLMDTHLDSAIHADPNLIGAFCGNGWDQPIRVDAISGTLATSALVCEPSLQQRSVSQYLTGRALYRCDSLGMCLNDSTSWENAYMAVCHWENTLHRSVSLGKGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDW4</accession>
    <name>A0A401QDW4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01038864">
        <property type="protein sequence ID" value="GCB83575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDW4"/>
    <dbReference type="OrthoDB" id="548795at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055308">
        <property type="entry name" value="TEX47-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24787">
        <property type="entry name" value="TEX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="33" mass="4009" checksum="FCD0D9257DC12A0E" modified="2019-05-08" version="1" fragment="single">YYENFLQKLQRCHQEGITGLLLLYPNYVIHVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE37</accession>
    <name>A0A401QE37_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01040275">
        <property type="protein sequence ID" value="GCB83624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE37"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8345" checksum="A80E9B58A14581F8" modified="2019-05-08" version="1" fragment="single">SGSQKPATASPETALSEDFEEYTKQRPIQTKIITQLVDRTILHVSLEKIPLQFMNYDAFYFLRNRKGKDILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFD1</accession>
    <name>A0A401QFD1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01058209">
        <property type="protein sequence ID" value="GCB84052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFD1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="268" mass="25553" checksum="989197999D19EDAA" modified="2019-05-08" version="1" fragment="single">MKGVAEVRPEIKTWSWLAKTTNTGPQDYFRRDSAGFDGAGVGVEGSAGFDSAGVCVEGSAGFDSIGVEGSASFDSVGVEGSAGFDSTGVQDSAGFESVGVDVEGSAGFRDGGAGVEGSAGFYGAGVGVEGSAGFDCAGVEGSACFDYVGLEGSAGFGGVGVLALQVLIVLVLVQRALLVLIVLVIGAGVEGSAGFESVGVEGSAGFDSAGVGVEGSAGFDSAGVGVKGSAGFYGAGVEGSAGFDSAGVGVEGSAGFDGAGVQSSAGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFK1</accession>
    <name>A0A401QFK1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01053595">
        <property type="protein sequence ID" value="GCB84198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFK1"/>
    <dbReference type="OMA" id="DMANGSM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.620">
        <property type="entry name" value="Helix Hairpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="10870" checksum="88984B936E8D7EF0" modified="2019-05-08" version="1">MDKANGSMDMANGSMDMANGSMDMANGTMDMANGSMDMANDSTDMANDSMDMVNDSMDMVNDSMDMANDSTDMANDSMAMANDSMDMANGSMNVANDSTDMASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHR6</accession>
    <name>A0A401QHR6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01099846">
        <property type="protein sequence ID" value="GCB84929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHR6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="137" mass="15949" checksum="214246F5DDAF91A9" modified="2019-05-08" version="1">MSEITVNVAWSVSESTLHVAWYVVRDFCPRGVERVQDYYPRGVERHLRLLSTWCGAWSEISIHVVWSMVRDYYPRGVGRGPRLLSTWCGAWSEITLNVVWIVVRDCYRRGLECGPRFLSTWCGAWSEITIHVVWSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIB2</accession>
    <name>A0A401QIB2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01121792">
        <property type="protein sequence ID" value="GCB85086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIB2"/>
    <dbReference type="OrthoDB" id="8190486at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="230" mass="24506" checksum="9A24D3CE4B62007C" modified="2019-05-08" version="1" fragment="single">MSTSGNANDSHLSSSSTEPRAAPASDTDRVKHSSGDRGFPAPGSQAHGSQVPLHHPGWVSRRNDLRVPEPSPDCGASEDRIEGGQLTYASLDAPGTTDAPLQDPRNFPCPQAIPLQPVVQASSHRLVSAATEGHEVNPDAITPGRHGTLASSAAEMLRHERYLQQCAANGADHPDLGGNCVYAEQSQSVMLPLLPNQPSLEDLTQLLNYSFLSHASFHPLELQVDETMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIE3</accession>
    <name>A0A401QIE3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0025830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01131347">
        <property type="protein sequence ID" value="GCB85154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIE3"/>
    <dbReference type="OrthoDB" id="10004364at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB85154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="48" mass="5490" checksum="EE84839DD91CD693" modified="2019-05-08" version="1" fragment="single">MSLATNRSLAEKNLEYQPRLEGGKGRLQEKYAALQSLYHGVLEQKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIT8</accession>
    <name>A0A401QIT8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01141539">
        <property type="protein sequence ID" value="GCB85278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIT8"/>
    <dbReference type="OMA" id="TGVKQTQ"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37917">
        <property type="entry name" value="PROTEIN CBG03580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37917:SF9">
        <property type="entry name" value="RHOPTRY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="191" mass="21531" checksum="15E30AB0A0300131" modified="2019-05-08" version="1" fragment="single">DHCEADWDHCEADRDQCEADRDHCEAGQDDCEADQDHCEADQNHCEADQNHCEQTRITVNQTGIIVNQTGITVKQTVITVRQTGITVKHTGITVKQTGITVNQTGITVKQTVITVRQTGITVKQTRMTVKQTRITVKQRGITVKQTRTTVKQTGITVKQTRITVKQTRITVKQTRITVKQTRITVKQTRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIX1</accession>
    <name>A0A401QIX1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0025939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01142088">
        <property type="protein sequence ID" value="GCB85321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIX1"/>
    <dbReference type="STRING" id="75743.A0A401QIX1"/>
    <dbReference type="OMA" id="EHESSIC"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19800">
        <property type="entry name" value="Bbox2_xNF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB85321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19192" checksum="5CF5BF2F21BE7C63" modified="2019-05-08" version="1" fragment="single">MALRQQIQGLTEETICPICLDFFTDPVTLDCGHNFCRSCIPEKEINSCPECREDFPEKSLRINRALGNLAEKTRKLNLNRKEKDSKLHCEKHQEELKLLCETDKKLICVICRDSREHRVHRFLPIDEAVKTYKDQMKSSFDSLTVKKSAVLQTKLKQKGKISEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIZ2</accession>
    <name>A0A401QIZ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01144821">
        <property type="protein sequence ID" value="GCB85333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIZ2"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="56" mass="5767" checksum="CFEB15F8E9FF955D" modified="2019-05-08" version="1" fragment="single">MASQPVLSKAVSSNYMATLTALIVVKEPIAGQAGQLLMQQPSVMAVGDEVSYASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJR8</accession>
    <name>A0A401QJR8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01182550">
        <property type="protein sequence ID" value="GCB85629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJR8"/>
    <dbReference type="STRING" id="75743.A0A401QJR8"/>
    <dbReference type="OMA" id="PGRKMME"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="20641" checksum="DDA9CBCAB83AE483" modified="2019-05-08" version="1" fragment="single">METDTSMEQIEEQKPEQIAEQIEEQKPEQIAEQKPEQIEEQKPEQIEEQKPEQIEEQKPEQIAEQKPEQIEEEKKEQIEEQKPEQIEEQKPEQIAEQKPEKIEEQKPEQIEEQKPEQIEEQKPEQIEEQKSEQIEEQKLDQIEEQKLEQIEEQNSEQIEEQKPEQIEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NG97</accession>
    <name>A0A401NG97_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA pseudouridine synthase Pus10</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0009077</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(54) in tRNA = pseudouridine(54) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:57876"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:57877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42533"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01003613">
        <property type="protein sequence ID" value="GCB59947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NG97"/>
    <dbReference type="STRING" id="75743.A0A401NG97"/>
    <dbReference type="OMA" id="LVISCQR"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2050:FF:000001">
        <property type="entry name" value="putative tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="20">
        <location>
            <begin position="107"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="21">
        <location>
            <begin position="287"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB59947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="527" mass="60234" checksum="7FDA0DBB6CFC5ECF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHD4</accession>
    <name>A0A401NHD4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Interleukin-12 subunit beta</fullName>
            <shortName evidence="5">IL-12B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytotoxic lymphocyte maturation factor 40 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">IL-12 subunit p40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IL12B</name>
        <name evidence="8" type="ORF">scyTo_0006850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IL-12B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002380">
        <property type="protein sequence ID" value="GCB60285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHD4"/>
    <dbReference type="STRING" id="75743.A0A401NHD4"/>
    <dbReference type="OMA" id="WSEWSHK"/>
    <dbReference type="OrthoDB" id="8670716at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050676">
        <property type="entry name" value="IL-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015528">
        <property type="entry name" value="IL-12_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019482">
        <property type="entry name" value="IL-12_beta_cen-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48485">
        <property type="entry name" value="INTERLEUKIN-12 SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10420">
        <property type="entry name" value="IL12p40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01928">
        <property type="entry name" value="INTRLEUKN12B"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0202">Cytokine</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU281113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="390" mass="45290" checksum="D197F2C833415176" modified="2019-05-08" version="1">MSDVTVSGESERHTQGKWEDLSLGREFPVRSGQRYGKQHRDYYGRRMVGRLFLCLCFLSLTVTVRMAFEEKYSIVNKTNQLVELNCEASSDQLWAGIHWRLDGVPLSKNAHSNKLNLEVTDRPDAGNYSCHMNSTGAIIKHYYILIDVERQTDKILKETNRKYITCQAERFGGTFTCFWTEREIAIFSASFHRDGWNGDTKDCVLTPCTSSECTVQATCTDQTFSPYAEELRQITITVEAATSKRYEKHTKHFYIRDILKPAAPKELTTTLRLHEVQVNWQYPDSWNSPRSYFPLLSQVSVELTSGKNRQRRRTRSKDASVESLIPGRATRKTHHRRKSHQSINYYTENSNLVFSVTKKQLQNIRRICVRVKELFFTSTWSEPSCKNYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHS6</accession>
    <name>A0A401NHS6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Frizzled-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0003932</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001119">
        <property type="protein sequence ID" value="GCB60426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHS6"/>
    <dbReference type="STRING" id="75743.A0A401NHS6"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000003">
        <property type="entry name" value="Frizzled class receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000029">
        <property type="entry name" value="Frizzled class receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF34">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019268225" description="Frizzled-2" evidence="16">
        <location>
            <begin position="19"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="17">
        <location>
            <begin position="37"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="18">
        <location>
            <begin position="243"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB60426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="63599" checksum="EF236053413B86D7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI25</accession>
    <name>A0A401NI25_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003684">
        <property type="protein sequence ID" value="GCB60518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI25"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10735" checksum="85CE8565CDA1475B" modified="2019-05-08" version="1">MTFQIPDINLETRGICNDSVMACFGEQLQNSTAPQLNILKFYYEEWSEEYMPHLSSRDTIRCPQQNHSKQNILEFLKKFKEFLDKKNKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIR9</accession>
    <name>A0A401NIR9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0003994</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23464"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:12575"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:132105"/>
            <dbReference type="EC" id="2.4.1.174"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus</location>
            <location evidence="1 13">Golgi stack membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01001140">
        <property type="protein sequence ID" value="GCB60755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIR9"/>
    <dbReference type="STRING" id="75743.A0A401NIR9"/>
    <dbReference type="OMA" id="MHAAADF"/>
    <dbReference type="OrthoDB" id="431432at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047237">
        <property type="term" value="F:glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000059">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF19">
        <property type="entry name" value="CHONDROITIN SULFATE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB60755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="535" mass="62296" checksum="7DE59C6040A34177" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ51</accession>
    <name>A0A401NJ51_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Polycystin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0006952</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002432">
        <property type="protein sequence ID" value="GCB60887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NJ51"/>
    <dbReference type="OMA" id="NCATQNA"/>
    <dbReference type="OrthoDB" id="6022660at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002088">
        <property type="entry name" value="Polycystic kidney disease 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000012">
        <property type="entry name" value="polycystin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000434">
        <property type="entry name" value="PC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006228">
        <property type="entry name" value="Polycystin_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00864">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF3">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00500">
        <property type="entry name" value="POLYCYSTIN1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019447120" description="Polycystin-1" evidence="17">
        <location>
            <begin position="44"/>
            <end position="4196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2898"/>
            <end position="2918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3104"/>
            <end position="3125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3145"/>
            <end position="3167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3387"/>
            <end position="3409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3415"/>
            <end position="3434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3502"/>
            <end position="3521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3740"/>
            <end position="3762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3774"/>
            <end position="3794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3822"/>
            <end position="3843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3866"/>
            <end position="3888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="3927"/>
            <end position="3950"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="18">
        <location>
            <begin position="242"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="881"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="984"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="1060"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="1141"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="1238"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="1319"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="1382"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="1496"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="1580"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="19">
        <location>
            <begin position="1923"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="22">
        <location>
            <begin position="1983"/>
            <end position="2669"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="21">
        <location>
            <begin position="2716"/>
            <end position="2886"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="20">
        <location>
            <begin position="2941"/>
            <end position="3056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4114"/>
            <end position="4196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="4137"/>
            <end position="4150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="4176"/>
            <end position="4196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB60887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4196" mass="466583" checksum="3FD29B7ED9950ABD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLI5</accession>
    <name>A0A401NLI5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0004149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001203">
        <property type="protein sequence ID" value="GCB61761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLI5"/>
    <dbReference type="STRING" id="75743.A0A401NLI5"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000010">
        <property type="entry name" value="Putative kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="107"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB61761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="336" mass="37385" checksum="0D790CFE4AF54C6A" modified="2019-05-08" version="1" fragment="single">MCNVHLSQSRDGTFLEILNICKEERAKKKNKPLNLKIHNSVGSCENIPAQRSPLLSERSLRSFFVGYPSFLPSTPPVHTEANFSSNTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGARLVRTESVPCDINNPLKKPPRYSDLHSSQTLPKTNKINKDHIPAPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSSQCTRQQKQFNLPGILSNIRLRAITSSDLLEGHSHTSPPQASHYFKYKQQFIFPDVTPEIQSRAPQVILHPVKSDPISEGTPALRVEVNEPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMX8</accession>
    <name>A0A401NMX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kelch domain-containing protein 8B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0007185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002557">
        <property type="protein sequence ID" value="GCB62204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMX8"/>
    <dbReference type="STRING" id="75743.A0A401NMX8"/>
    <dbReference type="OMA" id="HGEMIYL"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110070">
        <property type="term" value="C:cellularization cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902410">
        <property type="term" value="P:mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140014">
        <property type="term" value="P:mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051746">
        <property type="entry name" value="Kelch_domain_containing_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46260:SF2">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46260">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB62204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="354" mass="38634" checksum="F138AEBC22FCE76B" modified="2019-05-08" version="1">MAVSSVKSMYWEGFPPMPTKRVYCTPVYRDRQLFVLGGCSDTGLPLDKVEMLDVVSQKWTGLPSMPTPRAGAAAVILNKQILIIGGMNEEQSPLGSVDIFNMDEGKWEKKAPLGQPSMGITAVKKDGRVYALGGMGSDAAPQALVRVYEPARDHWQPLPPMPTPQYAASSFIKGNKIYILGGRQGKLPVTAFEALDLETKSWTKYPSIPTRRAFANCAMTEKCFYSLGGLQQPGPHNFYSRPHFVNTVEVFDIEQGIWTKQSRSTRMREKRADFSVGHIGGRVIAAGGLGNQPAPLGSVEGFNPSKRKWESLPSMNTPRSSCSSLQIDNMLFVIGGVAQGPSNAVEALCDRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNI6</accession>
    <name>A0A401NNI6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01005220">
        <property type="protein sequence ID" value="GCB62419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNI6"/>
    <dbReference type="STRING" id="75743.A0A401NNI6"/>
    <dbReference type="OMA" id="ACLSCKH"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01409">
        <property type="entry name" value="SIRT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003738">
        <property type="entry name" value="PRK05333.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="287"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="315" mass="35073" checksum="AE40FFC61430806A" modified="2019-05-08" version="1">MRLLSIFVVAEKCLLLKQTCRNYSSVTASNLAFVPSSRPLDSIKLEELQDFVLRSKKLFVLTGAGMSTESGIPDYRSEGVGLYARTAIRPIQHSEFIHSAKGRQRYWARNYVGWPLFCCHQPNVAHDVLSKWENLGKLHWLVTQNVDALHSKAGSQRLTELHGCTHRVICLGCGDVTPRRYLQDKFTALNPGWAEEAHGIAPDGDVFLTDEQVKNFCVPSCESCGGTLKPDVTLFGDIVNKEKVNFIYERVAESDAVLVAGSSLQVYSGYRFIIAAYEKKIPIALLNIGDTRADRQATLKINARCGEVLSCILHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNZ6</accession>
    <name>A0A401NNZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase with EF-hands</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0014513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01007816">
        <property type="protein sequence ID" value="GCB62600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNZ6"/>
    <dbReference type="STRING" id="75743.A0A401NNZ6"/>
    <dbReference type="OMA" id="WCEALES"/>
    <dbReference type="OrthoDB" id="442428at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000087">
        <property type="entry name" value="Serine/threonine-protein phosphatase with EF-hands"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012008">
        <property type="entry name" value="Ser/Thr-Pase_EF-hand_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000912">
        <property type="entry name" value="PPEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="670"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="707" mass="81779" checksum="BDD6E14B6F075024" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPG6</accession>
    <name>A0A401NPG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0007279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002605">
        <property type="protein sequence ID" value="GCB62763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPG6"/>
    <dbReference type="OMA" id="PANIHIF"/>
    <dbReference type="OrthoDB" id="160294at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF264">
        <property type="entry name" value="MUCIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="126"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB62763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="433" mass="49014" checksum="11BD308BE9B6E9B6" modified="2019-05-08" version="1">MRSSFCKNGKIECFDDSFISGEICDQPKIYFNCASAKEDEYGAAYQPTCQMHATETRSLATKCISGCVCPYGMVLNERGHCVYLQDCPCEFSGVYYRPWKTIVKECQKCICIQGKWECTGDAKCPSTCVIHGEGHITTFDGRQYVFDGNCEYTLVQDACSVNYRQPSFKIVSENIICGKTGVVCTKSIKIYFKDILIKLTDGQYQITPPNAARRLKVVSNPLYLKFDLSINAKLELTIIWNKNMNAYISITRLSEVYRMPYYDNCVRDACGCELVGDCECLCDAVAVYAKTCIDAGVCIDWRTPDFCPVYCDYFNTHKKDSTVDGSFWNAKNRWHYQPCLCPANIHIFGKFNMEGCYICGEYEFFHEELKRCVSCGKPSLIALPGQVDPQCQGEERHRRRSSETEEKMMEIAGEEGAQLVANGETRPARSKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPV4</accession>
    <name>A0A401NPV4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">General transcription factor IIE subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transcription initiation factor IIE subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0004320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with SND1. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001274">
        <property type="protein sequence ID" value="GCB62867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPV4"/>
    <dbReference type="STRING" id="75743.A0A401NPV4"/>
    <dbReference type="OMA" id="ILIRYPC"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000087">
        <property type="entry name" value="General transcription factor IIE subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021600">
        <property type="entry name" value="TFIIE_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF10">
        <property type="entry name" value="HTH TFE_IIEALPHA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11521">
        <property type="entry name" value="TFIIE-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="16">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB62867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="413" mass="47235" checksum="AF63C00ED741EDA6" modified="2019-05-08" version="1">MGDQSLLTEVPATLKRLAKYVVRGFYGVEYSLTLDILIRYPCVKEEDLQQLLKFEKKQLRSVLNTLKADKFLKSRIRVETNCEGKSSRHNYYYINYKLLVDVVKYKLDVVRRKIETDERNSSTRSSFKCPLCFSTFSDLEVNHLFDPCTGNFNCTYCHTEVEEDASAIPKRDARTILATFNEQIEPIYALLHETEDIALSHELLEPQPTEIPELALSQNQKIQNLKNNAHLERWSNKVCSDLYEQNIVVNVQESDVKTKKPVKPIKSQPIWMTTSTVDGAALDIVENAAEPAATETHDPSTNRNSKTSNYEVIKTLMIHEKKTLTGATVTSNANRSDADSETSESEDESKSARPLLNLQEEAFEREKPMVKVAGKLHLFSDISQNPELVALMTEQERESYISTCQEMFHLMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPY3</accession>
    <name>A0A401NPY3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0009601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003954">
        <property type="protein sequence ID" value="GCB62943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPY3"/>
    <dbReference type="STRING" id="75743.A0A401NPY3"/>
    <dbReference type="OMA" id="TCTRIMK"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000051">
        <property type="entry name" value="Cell division cycle protein 27 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="741"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="839" mass="93036" checksum="5DE487BC2A153A15" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQR6</accession>
    <name>A0A401NQR6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0014595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007886">
        <property type="protein sequence ID" value="GCB63184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQR6"/>
    <dbReference type="STRING" id="75743.A0A401NQR6"/>
    <dbReference type="OMA" id="WARWMIP"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000821">
        <property type="term" value="P:regulation of arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000056">
        <property type="entry name" value="Y+L amino acid transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF517">
        <property type="entry name" value="SI:DKEYP-120H9.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB63184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50664" checksum="D2457B35C66452DC" modified="2019-05-08" version="1" fragment="single">MEVDSKPATDGLRLKKDISLLHGICLIVGNMIGSGIFVSPKGVLIFSGSYGLSLIIWAIGGVFSVFGALCYAELGTTIKKSGASYAYILESFGGFLAFLRLWTSLLIVEPACQAVIAITFANYLIQPFFPSCEPPYSAVRLLAAFCIGLLTLVNCAKVKWGTTLQVVSTFAKVIALIIIIIAGLVRLCQGETDKFQNSFQGSKFNGGEMALALYSALYSYSGWDTLNFVTEEIQNPERMHEMKRKKGYDSEFMIPSLKKTFADEVLGYVKWFIPLSVAISCYGGLNSSIIASSRLYFVASREGHLPNVLCMIHIFRYTPIPALCFNGGMALIYLCVEDIYNLINYFSFNYWLFIGLSVASQIYLRWKFPEMPRPVKLSLFFPIVYCLCSLFLVVMPLYSDTVNSLIGIAVALSGAPVYFFCVHLSSEKRPKCLEKLLRKFQRYLQLFMSLYLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRH1</accession>
    <name>A0A401NRH1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0014618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007922">
        <property type="protein sequence ID" value="GCB63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRH1"/>
    <dbReference type="STRING" id="75743.A0A401NRH1"/>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002280">
        <property type="term" value="P:monocyte activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050765">
        <property type="term" value="P:negative regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033292">
        <property type="term" value="P:T-tubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF44">
        <property type="entry name" value="DYSFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="164" mass="18643" checksum="ABEE08B5F0086044" modified="2019-05-08" version="1">MACSLGGYGVWSQVCSKIIEKNANPQWNQSLVLPIRFPSMCEKMRIRVTDWDRLTHNDVIGTTYLCMSKISAPGGEIEVDDGLGYLPTFGPCFVNLYGSPREFTGFPDPYVDMNLGKSEAMAYRGRILLELSTKLVDQMEQKIEEIPSDDLLRLEVISWTFMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRU9</accession>
    <name>A0A401NRU9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0014641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007941">
        <property type="protein sequence ID" value="GCB63572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRU9"/>
    <dbReference type="STRING" id="75743.A0A401NRU9"/>
    <dbReference type="OMA" id="MSPNDAH"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.80:FF:000001">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009404">
        <property type="entry name" value="Transcription_factor_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="11">
        <location>
            <begin position="105"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="10">
        <location>
            <begin position="195"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB63572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46286" checksum="96432A0AA845A303" modified="2019-05-08" version="1" fragment="single">IGIIESNGEIKIFTDQNVSPAKIALVTVASSHLTTPGKQILPKTLGLSNVSNAPQMIIGTPQRAPTTPTVLVGSPHGPNIHMLTQGEASDSSPWSTGKRNKKGEKNGKGLRHFSMKVCEKVQQKGTTTYNEVADELVAEFSNTNNQESGSDEQGYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEMEKRKKMETIKQKQSQLKELLLQQIAFKNLVQRNRLVEQQSGRVPPPNTAIQLPFILVNTSKKTIIDCSISPDKFEYFFNFDNTFEIHDDIEILKRMRMAFGLESGGCSADELKMAKSLIPHVLEPYVIEMAKGVQNVNSGPSSVAASASSSSIQSNRAFIVGDELALPTDTEVALVTSQAQGSFNGTHYSDPRMETPTSYIEDDDDEDDDDEEEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRZ8</accession>
    <name>A0A401NRZ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reticulophagy regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007950">
        <property type="protein sequence ID" value="GCB63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRZ8"/>
    <dbReference type="STRING" id="75743.A0A401NRZ8"/>
    <dbReference type="OMA" id="ANIRFXA"/>
    <dbReference type="OrthoDB" id="10029527at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043384">
        <property type="entry name" value="RETREG1/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659:SF3">
        <property type="entry name" value="RETICULOPHAGY REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30485" checksum="7BADE03DD546DD76" modified="2019-05-08" version="1" fragment="single">LCVLLWPLVTSCDLGQSIYNKIDPVLQRLDFGLKDYVQRLQRRREMKQKELAERRSEDESEADTSALCPKVSNSGAGKELSISDTEPSETWTENGTFNLSGGHTPQTDASDDLDRPSDHEETFARDLPEFPSIDNKGTTDDDDDSSIGIPMPPIPTLEPNEPGSHQEGISTGTAITGLSLNLSNEQSFNLISTMATDVIAAAVSSAVKDQLQALETNPTMLPQLNSSEETDTEEADDFELLDESELEQIESELGLEQGQAANQKGKDDKSGFLSNLLGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NST4</accession>
    <name>A0A401NST4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Paired box protein Pax-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0011682</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005400">
        <property type="protein sequence ID" value="GCB63904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NST4"/>
    <dbReference type="STRING" id="75743.A0A401NST4"/>
    <dbReference type="OMA" id="NQRRQAC"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000516">
        <property type="entry name" value="Transcription factor Toy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB63904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="281" mass="31082" checksum="1D02413693514213" modified="2019-05-08" version="1">MTEVLSASGALRTLATEEHPMGADGMYDKLRMLNVQTGSWGGRPGWYQGSSVTGQGSTDSCQQLEVRGENGSGANVNGDDSDESQIRLQLKRKLQRNRTSFTQDQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQACSGPSHVPINSSFSPTLYQSIPQPATSGNDFHYLLPFQQSVQSVPGQTASYSCMIPASPAVSVRSYDAYTPPHMQPHMNSQSLASTGGSSTGLISPGVSVPVQVPGGDQDMAQYWSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU07</accession>
    <name>A0A401NU07_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IFT81 calponin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IFT81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005447">
        <property type="protein sequence ID" value="GCB64376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU07"/>
    <dbReference type="STRING" id="75743.A0A401NU07"/>
    <dbReference type="OMA" id="TSENNAC"/>
    <dbReference type="OrthoDB" id="276029at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.70">
        <property type="entry name" value="Intraflagellar transport protein 81, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029600">
        <property type="entry name" value="IFT81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041146">
        <property type="entry name" value="IFT81_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043016">
        <property type="entry name" value="IFT81_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18383">
        <property type="entry name" value="IFT81_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT81 calponin homology" evidence="8">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="120"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="307"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="435"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB64376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="628" mass="73788" checksum="7472C5B131DE3963" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUB4</accession>
    <name>A0A401NUB4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004106">
        <property type="protein sequence ID" value="GCB64478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUB4"/>
    <dbReference type="OrthoDB" id="6407068at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026698">
        <property type="entry name" value="UPF_C3orf38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21084">
        <property type="entry name" value="DENSE INCISORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21084:SF1">
        <property type="entry name" value="DENSE INCISORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15008">
        <property type="entry name" value="DUF4518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="50670" checksum="8859AD41D2F7229F" modified="2019-05-08" version="1" fragment="single">AISVVLNCSQSAEELLKRRKVVREAILKYLIRHDVVTSASADKQQLINKALFYWIQEEWKKKKVIDKTNHNLLLQVRKQELEQKEIEKAKVRAVAQRELEQARQVEDQLRRQVEEQARRREEEQRRQAEEQRRQAEEQRRRQVEEQARQAEEQRRRQVEEQARRAEEQRRRQVEEQARQAEEQRRRQVEEQIKKQGEAKARRELEEQIKRQVQEQMREQAQDEATRQLEIQMNINLNITQCETLSQTDGDFDCQMIGEKFCQWFFILLNSQNPSFGRQPEEWGPQHFWEDAILHFAYSVLEHTSEQQKTEQYQSSAMVSQRLLSLVKDEQLLFNPNISKNGMRSVTSKHGIVVVAVAGTVHKNTQCLGIFEQLFGLVRTPVGRSNWKIKYVNLQMKALSGQQEISQPSLSVEQPALMAHLNELSVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUH5</accession>
    <name>A0A401NUH5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tf2-1-like SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001374">
        <property type="protein sequence ID" value="GCB64494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUH5"/>
    <dbReference type="OrthoDB" id="1939135at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="24241" checksum="EF5E49109B51AD25" modified="2019-05-08" version="1">MTRRPMKGTEYLLGLDLASPTVTALTHEKAVQQILENVKAAQLAAAVRLGTHKKQSKVCFDKTVHATEFVVGQQVMLSLYNPSSFLSPKFAGPYTISDKVSPSVYKITYPNGNSAWFHINQLKAYGSQNNHAHHISLAAAGEHALPSNDIFLPSPTCPDTTPPPEAQLRLSLSPTDSDSDSPSTPPYDYTPAPGPTPSDSEHDSSDPFEIMYIKAPVPDPPSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVT5</accession>
    <name>A0A401NVT5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000066">
        <property type="protein sequence ID" value="GCB64972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVT5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019142509" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8321" checksum="45582263B9DE2D9F" modified="2019-05-08" version="1">MKPAMHLVPIQWALGVLALGVRPAQGGSPASASQQFQILRKSKNVNKSQLIDNFWNILLPRKREDSSANLIRQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWA9</accession>
    <name>A0A401NWA9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0004722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001418">
        <property type="protein sequence ID" value="GCB65149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWA9"/>
    <dbReference type="STRING" id="75743.A0A401NWA9"/>
    <dbReference type="OMA" id="THRMTTF"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000574">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="123"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB65149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="865" mass="97894" checksum="143A08D3FA9453ED" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX40</accession>
    <name>A0A401NX40_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI-anchor transamidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-glycan biosynthesis class K protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0004790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heteropentamer. Part of the GPI-anchor transamidase complex, consisting of PIGK, PIGT, PIGS, PIGU and GAA1. Interacts with GPAA1. Interacts with PIGT; this interaction, via a disulfide link, stabilizes the expression of GAA1 and PIGK and links them to PIGS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001438">
        <property type="protein sequence ID" value="GCB65441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX40"/>
    <dbReference type="STRING" id="75743.A0A401NX40"/>
    <dbReference type="OMA" id="DYRSYEX"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB65441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="272" mass="31429" checksum="925F5A7807A21993" modified="2019-05-08" version="1">MKLLLHCSIECFQFRCSTVQVCTSRFWFNYRHVANTLSIYRSVKRLGIPDSHIVLMLADDMACNPRNPKPATIFSHKNMELNVYGDNVEVDYRGYEVTVESFLRVLTGRLPQSTPRSKRLLSDDRSNILIYMTGHGGNGFLKFQDSEEITNVELADAFEQMWQKRRRPLPRVDGVVVHQPDLAIGVHLMDRYTYYLLEFLEDIHPASQINMNDLFRVCPPSQCVSTPGHRTDLFQRNPKSVLITDFFGSVRKVEITNHIIQLTANDTETETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY26</accession>
    <name>A0A401NY26_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0007784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002879">
        <property type="protein sequence ID" value="GCB65779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY26"/>
    <dbReference type="STRING" id="75743.A0A401NY26"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="122" mass="13705" checksum="E382E03AF2E6CBE3" modified="2019-05-08" version="1">MAGRRGPWMLRGLRQPASGGFGRSFVSGFLAGSLLGSTGCALALHWRQQQKRQQQEHPNDSHLEKYGIPVIGTEIRYCTNHISSYDQAKKTPRWVLEHITKEKVQGIDCKIKPLHILCLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ64</accession>
    <name>A0A401NZ64_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005633">
        <property type="protein sequence ID" value="GCB66145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ64"/>
    <dbReference type="STRING" id="75743.A0A401NZ64"/>
    <dbReference type="OMA" id="DYRVTIN"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB66145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="13952" checksum="1172CBA69EC6276E" modified="2019-05-08" version="1">MVSVNFGQQSTQLPVMMVTGEEPSLLGCDRLKEIKLNWSEIFHVSEWKLPERARKYEIFFCDGLKSKDYKLRFMWIQRQLPRFFKARSVPYVLREKVDIEVNRLEKHGIIQPVSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0B1</accession>
    <name>A0A401P0B1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proline-rich transmembrane protein 3/4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0004986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001508">
        <property type="protein sequence ID" value="GCB66544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0B1"/>
    <dbReference type="STRING" id="75743.A0A401P0B1"/>
    <dbReference type="OrthoDB" id="10066605at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043242">
        <property type="entry name" value="PRRT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47400">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47400:SF1">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019247085" description="Proline-rich transmembrane protein 3/4 domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="10">
        <location>
            <begin position="366"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="918"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB66544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="977" mass="108261" checksum="9EB732C2314C7C80" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0R9</accession>
    <name>A0A401P0R9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="17">3.1.3.16</ecNumber>
            <ecNumber evidence="17">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0000632</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 22">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Microtubule inner protein component of sperm flagellar doublet microtubules. Interacts with VRK3; this interaction activates DUSP3 phosphatase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="17"/>
    <dbReference type="EC" id="3.1.3.48" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01000121">
        <property type="protein sequence ID" value="GCB66718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0R9"/>
    <dbReference type="STRING" id="75743.A0A401P0R9"/>
    <dbReference type="OMA" id="RHKMDVK"/>
    <dbReference type="OrthoDB" id="253091at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14579">
        <property type="entry name" value="DUSP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000065">
        <property type="entry name" value="Dual specificity protein phosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 17" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="99"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="16">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB66718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="184" mass="20866" checksum="99899E1BC54517B0" modified="2019-05-08" version="1">MSEHRLMVEELNELLANDSGFYSLPSQHCNEVYSRIYVGNAFVAQNLMRLERLGISHVLNSAEGNSFMHVNTNAEFYAGSGIVYHGIKANDTEAFNLSAYFEEAADFIEKSLAQKDGRVFVHCREGYSRSPTLVIAYLMLRHKMDVKTALLTVRQKREIGPNDGFLRQLCQLNEKLVKEGKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0Y2</accession>
    <name>A0A401P0Y2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Laminin subunit alpha-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0005035</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001525">
        <property type="protein sequence ID" value="GCB66795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P0Y2"/>
    <dbReference type="OMA" id="ISHCAAH"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043256">
        <property type="term" value="C:laminin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000271">
        <property type="entry name" value="Laminin alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000083">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000388">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000033">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000034">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000084">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000151">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009254">
        <property type="entry name" value="Laminin_aI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010307">
        <property type="entry name" value="Laminin_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06008">
        <property type="entry name" value="Laminin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06009">
        <property type="entry name" value="Laminin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="220"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="356"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="451"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1157"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1206"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="17">
        <location>
            <begin position="1277"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1540"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1596"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1650"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1695"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2357"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2567"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2749"/>
            <end position="2919"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3075"/>
            <end position="3249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2845"/>
            <end position="2866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1931"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2845"/>
            <end position="2862"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1206"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1208"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1227"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1566"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1621"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1633"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1667"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1715"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB66795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3252" mass="358197" checksum="9C5BF8E00325E80F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P227</accession>
    <name>A0A401P227_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MABP1/WRD62 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007082">
        <property type="protein sequence ID" value="GCB67184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P227"/>
    <dbReference type="STRING" id="75743.A0A401P227"/>
    <dbReference type="OMA" id="QKSYMNP"/>
    <dbReference type="OrthoDB" id="6154712at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055292">
        <property type="entry name" value="MABP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056364">
        <property type="entry name" value="WDR62-MABP1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24795">
        <property type="entry name" value="WDR62-MABP1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="MABP1/WRD62 coiled-coil" evidence="4">
        <location>
            <begin position="946"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB67184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118114" checksum="D2F50F021F6B542C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P277</accession>
    <name>A0A401P277_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004360">
        <property type="protein sequence ID" value="GCB67231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P277"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="85" mass="9304" checksum="195E6615B79E3BDF" modified="2019-05-08" version="1">MNRYLDYAPCIPLPSYNIELPLCPGQLTLTLRSSEADGERTALGAGPAAAPGTHGRYPEIEHKGRGHRYNARMSRSGVQLHIISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2F6</accession>
    <name>A0A401P2F6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Perilipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0005107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001562">
        <property type="protein sequence ID" value="GCB67301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2F6"/>
    <dbReference type="STRING" id="75743.A0A401P2F6"/>
    <dbReference type="OMA" id="HAICQML"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.170">
        <property type="entry name" value="Perilipin, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF11">
        <property type="entry name" value="PERILIPIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB67301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="415" mass="45287" checksum="63CBFB647292BB21" modified="2019-05-08" version="1">MASTKNVANTEGQENGNQNVVDRVASLPLVSSACEQVSAVYMSTKESSPAVKTICDLAEQGVKTISTVAATGAKPIVDKLEPQIAVANEYACKGLDKLEEKLPILHQVTDQVLAETKELVSSKMANVKESVMGVVDMTTTAVQGNLEKTKAVVIEGASAVGQLVATGVDISLIKSEELVDHYLPMTKEELAKVATSTEGSNSAAVQEQSYYVRLGSLSSKVRNRAYQYSISKMQQAKQNGQETLSHLYNLVDLIESAKRSAESTHLKLEDVRATLTRILVDWRKQQPDGKAKEELSDQSERIESETLAMTQTFSDQLQTICRTLASSVRGLPQNIEDQVQQVCKLAEEIYSSLSSATSFQDLSAPFLTQTKEQMLKISEGIDGVMDYLLHNTPLNWLVGPFIPQLAEDQGQNKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4D6</accession>
    <name>A0A401P4D6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">EMI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0005237</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MEGF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001609">
        <property type="protein sequence ID" value="GCB67983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4D6"/>
    <dbReference type="STRING" id="75743.A0A401P4D6"/>
    <dbReference type="OMA" id="CPCNVTN"/>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000014">
        <property type="entry name" value="Multiple epidermal growth factor-like domains protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000114">
        <property type="entry name" value="Multiple epidermal growth factor-like domains protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000006">
        <property type="entry name" value="Multiple epidermal growth factor-like domains protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057138">
        <property type="entry name" value="EGF_PEAR1L-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052485">
        <property type="entry name" value="MEGF_diff_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24052">
        <property type="entry name" value="DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24052:SF13">
        <property type="entry name" value="MULTIPLE EGF LIKE DOMAINS 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23301">
        <property type="entry name" value="EGF_PEAR1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EMI" evidence="15">
        <location>
            <begin position="82"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB67983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="88039" checksum="036E14C63E89B950" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4Z5</accession>
    <name>A0A401P4Z5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucocorticoid-induced transcript 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000172">
        <property type="protein sequence ID" value="GCB68160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4Z5"/>
    <dbReference type="STRING" id="75743.A0A401P4Z5"/>
    <dbReference type="OMA" id="QWPRDTD"/>
    <dbReference type="OrthoDB" id="10037581at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026642">
        <property type="entry name" value="Glcci1/FAM117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972">
        <property type="entry name" value="AGAP011572-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972:SF7">
        <property type="entry name" value="PROTEIN FAM117A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15388">
        <property type="entry name" value="FAM117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55485" checksum="B11E6DEE389C0CDA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P683</accession>
    <name>A0A401P683_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004496">
        <property type="protein sequence ID" value="GCB68635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P683"/>
    <dbReference type="STRING" id="75743.A0A401P683"/>
    <dbReference type="OMA" id="XKLRQDI"/>
    <dbReference type="OrthoDB" id="1918044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20819">
        <property type="entry name" value="C1_DEF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000042">
        <property type="entry name" value="differentially expressed in FDCP 8 homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047983">
        <property type="entry name" value="DEF8_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB68635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="408" mass="47493" checksum="F2B5206169747A91" modified="2019-05-08" version="1">MGGLYPDSLYREVNAHADRVMDLGLAEDHFSKPVGSFVALDIENLKHAIDEVKQVILDLPEHSEKQKDAVVKLIHLRLKLQELKDPDEDEPNIRILLEHRFYKEKSKSVKQFCDKCSTIIWGLLQTWYTCTGCYYRCHSKCLNQIPKSCVRSKVSHQSEFELNICPEVGLDMQDYRCGECRQPISLRGVPSEARMCDYTGRYYCSSCHWNDAAVIPARVIHNWDFETHKVCRYSMRYLALMISRPVLKLRVINPLLFNYVEELVEIRKLRQDILLMKPYFITCKEAMEARLLLQLQDRQHFVENDEMYSLQDLIDIATGRLSCTLTEVHTIFAKHIKLDCERCQAKGFVCELCKEGDVLFPFDSHTSVCQDCSAVFHRDCYYDNSTTCPRCPRLSMRRQSQIGPTHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P731</accession>
    <name>A0A401P731_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0012341</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005936">
        <property type="protein sequence ID" value="GCB68942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P731"/>
    <dbReference type="STRING" id="75743.A0A401P731"/>
    <dbReference type="OMA" id="GRCTENY"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000026">
        <property type="entry name" value="contactin-associated protein-like 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF40">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Laminin G" evidence="12">
        <location>
            <begin position="91"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB68942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41710" checksum="C09B609AEB84B366" modified="2019-05-08" version="1">MGAMSSKHKKFGDVCTDYLSILIGFIHNRSLTIEMLTKDCPIPQANDTGLLSYKDHLPLTQLIIGDTNRTDSKAAYRLGPLRCNGDNNYWNAASFNTESSYLHFPTFHGELSADISFFFKTSAASGVFLENLGIKDFIRIELNSPAEVLFSFDVGNGPFVVAVVSPSQLNDNQWHYVEAERNIKAASLRVDHLPRIAREATADGHIHLQLNSQLFVGGTALRQKGFVGCIRALQLNGVNLDLEERAKMTPGVNPGCPGHCTSYGNLCHNGGQCIEKYNGYSCNCTPSAYDGPFCKKEVSAFFEIGTSLIYNFQEFYGIAKNLSAHLSAIYMDRTISTENTAFSFQTTRAPSILLYVDSYHEEYLAVILLQNAFSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P781</accession>
    <name>A0A401P781_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000201">
        <property type="protein sequence ID" value="GCB68976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P781"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8881" checksum="AF14A48DA7BD914D" modified="2019-05-08" version="1">MALIVTTFAERFFSVLFQIFETQTVANIVEEKKYPSLALTEIAFVFRCATTKLWPLRQYHRMTSRYGKTNKSWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8J1</accession>
    <name>A0A401P8J1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FUN14 domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Hepatitis C virus core-binding protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0008391</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways. May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003200">
        <property type="protein sequence ID" value="GCB69469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8J1"/>
    <dbReference type="STRING" id="75743.A0A401P8J1"/>
    <dbReference type="OMA" id="AAPSFKM"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF5">
        <property type="entry name" value="FUN14 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB69469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="16967" checksum="0CCC3C3D1160C55B" modified="2019-05-08" version="1" fragment="single">GRSRMAEAKDQGNDDGQFEVLDLAEYAKRQRWWNRFFGRNSGPIAEKYTVATQLMIGGASGWCAGFLFQKVGKLAATAVGGGFFLLQIANHTGYITVDWKRVERDVNKAKKQLKIGKNKVTPEVHGAIDEVTVFVKKNIVLTGGFVGGFLLGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P933</accession>
    <name>A0A401P933_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPHN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003223">
        <property type="protein sequence ID" value="GCB69671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P933"/>
    <dbReference type="STRING" id="75743.A0A401P933"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB69671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="48" mass="5307" checksum="CC3AD176AFDFAC4D" modified="2019-05-08" version="1" fragment="single">MATEGLLLTNHEHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9K8</accession>
    <name>A0A401P9K8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0010650</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with ADAM10; the interaction influences ADAM10 substrate specificity, endocytosis and turnover.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004630">
        <property type="protein sequence ID" value="GCB69857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9K8"/>
    <dbReference type="STRING" id="75743.A0A401P9K8"/>
    <dbReference type="OMA" id="EMNESMD"/>
    <dbReference type="OrthoDB" id="10051815at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03158">
        <property type="entry name" value="penumbra_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000011">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF159">
        <property type="entry name" value="TETRASPANIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB69857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="206" mass="22978" checksum="51311EB2D9E7C61B" modified="2019-05-08" version="1" fragment="single">FLYTLAIVLILELLGGVVALIFRNQTLDFINKNIRKGIKHYYDDLDFKNIMDFVQEEFKCCGAEDFTDWSMNMYHNCKGRATGPLACGVPYSCCIWNKTDVANTMCGYKTLNQDRFDLLYTIYVGGCTDAVLNWFLGHYAVMAGLLLGIIAPQFLGVLLTWLYISRLEDIIYAYDAVDSCLTSPGEGVSTSGTGCCLCLPTLDTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9V9</accession>
    <name>A0A401P9V9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Charged multivesicular body protein 4c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0005566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001751">
        <property type="protein sequence ID" value="GCB69916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9V9"/>
    <dbReference type="STRING" id="75743.A0A401P9V9"/>
    <dbReference type="OMA" id="DKIDDMM"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000001">
        <property type="entry name" value="Charged multivesicular body protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF77">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28511" checksum="7E82765CC56AB758" modified="2019-05-08" version="1" fragment="single">VQCVSRRCTCCLRCSVVWRRRTVVMKKFSHSLKGGPSSSRFRSRASKQGPTPQEALCRLRETEEMLTKKQEYLENRIQRELDTARRSGTKNKRVALQALKRKKRFEKQLTQIDGTLSTIEFQREALENANTNTEVLKSMGYAAKAIKSVHEHIDLDKIDEMMQDITEQQEIAQEISDAISNPTAFGSEFDEDELLAELEDLEQEELSKKMTKVLPKVPTTSLPSRQVKTQKKTKEEDAILKHLKAWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAZ0</accession>
    <name>A0A401PAZ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0005641</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01001787">
        <property type="protein sequence ID" value="GCB70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAZ0"/>
    <dbReference type="STRING" id="75743.A0A401PAZ0"/>
    <dbReference type="OMA" id="KHTVVKL"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF116">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0114">cAMP</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="44"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="351" mass="40621" checksum="A401F7D7B1C40A92" modified="2019-05-08" version="1">MGNAATAKKGNEIESVKEFLAKAKEDFLRKWESPPQNTAGLDDFERQKTLGTGSFGRVMLVKHKGTEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCRGPGDTSNFDDYEEEDIRVSLTEKCAKEFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD08</accession>
    <name>A0A401PD08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L40, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0010903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004802">
        <property type="protein sequence ID" value="GCB71002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD08"/>
    <dbReference type="STRING" id="75743.A0A401PD08"/>
    <dbReference type="OMA" id="KEWARYK"/>
    <dbReference type="OrthoDB" id="5977625at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3440:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039145">
        <property type="entry name" value="Ribosomal_mL40_metazoa/plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="254" mass="29353" checksum="F1C81DA1B21D8070" modified="2019-05-08" version="1">MCFSDGRTARQQADEEAGNWPKNFKFDILLFCGLLRRGCDLVGERGRAREIGKGVDKEAATLHGGHVLDSPAGHRPDSSFSVECFCTILSLADGESLPMRAEPKKKKKVDPRREQAVRDRLRKRLKKLERVPPELIPIEDFITRTKFLDESRIRDPPKLPVEETERRALLMKKWSRYKQKEHEKEAEMIESMIEAQQQALQELRLESEELYQAAIKRNQGLFPLELQGCRFTPPIANYEAPNGKYRDITKVYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEM1</accession>
    <name>A0A401PEM1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0005990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001952">
        <property type="protein sequence ID" value="GCB71572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEM1"/>
    <dbReference type="STRING" id="75743.A0A401PEM1"/>
    <dbReference type="OMA" id="ITFFHEE"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000031">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF3">
        <property type="entry name" value="POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="2" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport N-terminal" evidence="12">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="105"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB71572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47438" checksum="9F55959951C195EC" modified="2019-05-08" version="1">MRREAEDEGSRSLQQQTGKEQNSVGFKVEAAAAGGGGGDDAMLVQEGDEFPRYSSMQSHFNALLQPGVNKFSLRMFGSQRGVEKEQQRVKTAGYWIIHPYSDFRFYWDLVMLMLMVGNLIIIPVGITFFSESTSTIWIVFNVASDTFFLVDLMVNFRTGIVVEDNAEIILDPTVIKWKYLKSWFIIDFVSSIPVDYIFLIIEKGFDSDVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDFASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQGFPPDCWVSLNGMVNDSWGMQYSYALFKAMSHMLCIGYGARAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKALENFYRSFLCYGIVIAESSFVRSQKLTEGRVLKWLLISLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEM3</accession>
    <name>A0A401PEM3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003490">
        <property type="protein sequence ID" value="GCB71561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEM3"/>
    <dbReference type="STRING" id="75743.A0A401PEM3"/>
    <dbReference type="OMA" id="HVRIAHT"/>
    <dbReference type="OrthoDB" id="8016097at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000038">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039330">
        <property type="entry name" value="CAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37354">
        <property type="entry name" value="CHROMOSOME ALIGNMENT-MAINTAINING PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37354:SF1">
        <property type="entry name" value="CHROMOSOME ALIGNMENT-MAINTAINING PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="633"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="697" mass="79706" checksum="8FF5089FA6D54233" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PER8</accession>
    <name>A0A401PER8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0006015</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001961">
        <property type="protein sequence ID" value="GCB71627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PER8"/>
    <dbReference type="OMA" id="VTDICPW"/>
    <dbReference type="OrthoDB" id="5823771at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 179-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="19">
        <location>
            <begin position="128"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="796"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="901"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1303"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1358"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="963"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1007"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1358"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1388"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB71627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1410" mass="156579" checksum="D2FD1C095B52E017" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEW0</accession>
    <name>A0A401PEW0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 181</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0001640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts with HOOK1. Interacts with HOOK2. Interacts with HOOK3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCDC181 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000378">
        <property type="protein sequence ID" value="GCB71634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEW0"/>
    <dbReference type="STRING" id="75743.A0A401PEW0"/>
    <dbReference type="OMA" id="YRYTDWY"/>
    <dbReference type="OrthoDB" id="6288248at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026687">
        <property type="entry name" value="CCDC181"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14320">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14320:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="258"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB71634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="511" mass="59941" checksum="3457DFCA231101B8" modified="2019-05-08" version="1">MSEDNSVSSQVEEYEDDFEKDLDWLINEETKNSDENPEDYEEDKAIEPKIDKDLDHKEREEKKSAVDEKQSRSPAEKSCELNEDFKKTTGISNGKGKVIVNQPDPISDSDSESSFQELKQEDQQDAEELTEEVKRYIMEKIEQANKKLLDEDPIDQNRERRLKFKDNLVDLEVPPVKLSEIEKDRGEVTGQMSEMCISNDAEKENNHAEGKVDDEKNKDKKVLMEKDGKFELVSLEDFESQGLLPQIAVAFSENECKQSHCSNELNSDNPKGNNLSSRQNNLSSSLTEMLHVPKPPDEPKDRATSAANTQKNAAQKILPRRVQSAIMSPKLTHLNSSEQKELNWRIQKKEQHKTEVGAKKTEEEMRKKEENKIAFGVWLQKKKQQHQEERRIQCAKELERKNSKEYRDPNEAFNLWLKKKREQQIKEQQMEAMRKREQDYNSKVYTREDSEKAFKQWLKRKKAEKRAEQLAAKERCRKFLMEARRVKRMQTLLCTLSESKSFQFDNYGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEY1</accession>
    <name>A0A401PEY1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0008899</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003514">
        <property type="protein sequence ID" value="GCB71687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEY1"/>
    <dbReference type="STRING" id="75743.A0A401PEY1"/>
    <dbReference type="OMA" id="QPMDTGN"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10497">
        <property type="entry name" value="MH2_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF36">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="12">
        <location>
            <begin position="273"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB71687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="467" mass="52499" checksum="578FEAD1556DCBEE" modified="2019-05-08" version="1">MTMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEDLEKALSSPGQPSRCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDVCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEFNPQHSLLVQFRNLSHNEPHMPHNATFPDSFQQPNSNPFPISPNSPYPPSPASTTYPSSPASSGPSSPFQMPADTPPPAYMPPEEQINQDSTQPMDTGNVMMTSSILNLPIISARDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGX4</accession>
    <name>A0A401PGX4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0006265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002081">
        <property type="protein sequence ID" value="GCB72358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGX4"/>
    <dbReference type="STRING" id="75743.A0A401PGX4"/>
    <dbReference type="OMA" id="MEYEAND"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15891">
        <property type="entry name" value="SNARE_Vti1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000024">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000001">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="89"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB72358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="177" mass="20709" checksum="77100CEDFAC62BBB" modified="2019-05-08" version="1">MDDKKCMVANVEKQMEEARELLEQMDLEVREIPLQSRGLFSTRMKSYKQELEKLDKDFKRSRIAYSDEVNLRNELLGDDGNTSEKQRACLLDNTERLERSTRRLEAGYQLTVETEQIGQGILENLHHDKEKIQRARERLRETDTNLGKSSRVLTGMLRRVAVDECELFFGDLQGRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHK1</accession>
    <name>A0A401PHK1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Auxilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DnaJ homolog subfamily C member 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0006367</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Forms a complex composed of HSPA8, CLTC and DNAJC6. Interacts with HSPA8/HSC70 in an ATP-dependent manner; this interaction stimulates the HSPA8's ATPase activity. Interacts with CLTC; this interaction produces a local change in heavy-chain contacts, creating a detectable global distortion of the clathrin coat. Interacts with AP2A2. Interacts with DNM1(GTP-bound form); this interaction allows clathrin-coated vesicle (CCV) formation at the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002134">
        <property type="protein sequence ID" value="GCB72569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHK1"/>
    <dbReference type="STRING" id="75743.A0A401PHK1"/>
    <dbReference type="OMA" id="QCVFLVI"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14563">
        <property type="entry name" value="PTP_auxilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000001">
        <property type="entry name" value="cyclin-G-associated kinase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000255">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF4">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE AUXILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0729">SH3-binding</keyword>
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        <location>
            <begin position="118"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="429"/>
        </location>
    </feature>
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        <location>
            <begin position="925"/>
            <end position="989"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="496"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="706"/>
            <end position="854"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
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        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
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            <begin position="708"/>
            <end position="723"/>
        </location>
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            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <end position="796"/>
        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064305"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00075670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB72569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="989" mass="107838" checksum="8815CFFFD9465822" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJT4</accession>
    <name>A0A401PJT4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002326">
        <property type="protein sequence ID" value="GCB73382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJT4"/>
    <dbReference type="STRING" id="75743.A0A401PJT4"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB73382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="99" mass="11072" checksum="4A115DE46F0F76A2" modified="2019-05-08" version="1">MWGNSSNCEAASFQPAGLMEKIQAIAQNVSNLTTKMEQLLQMSLTARRDVAFYEKAKGKEVSQCEVPKDPKFPDCLGKIEVSSQYSSLFRVFLNVAYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKB9</accession>
    <name>A0A401PKB9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-binding protein inhibitor ID-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Inhibitor of DNA binding 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inhibitor of differentiation 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Heterodimer with other HLH proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000666">
        <property type="protein sequence ID" value="GCB73528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="RCKMEED"/>
    <dbReference type="OrthoDB" id="10047910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding protein inhibitor ID-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF6">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR ID-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB73528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="14501" checksum="A9663E830A0D401F" modified="2019-05-08" version="1">MKAVSDVPALKKAGCGEMTLHCLSERSLSIARCKMEEDSLDLQYDMKDCYSKLKQLVPTIPQNKKVSKVEILQHVIDYILDLQLALEMHPALVRAQPAICPTAPRNPLTALNTDQAGSKVRRPEDSILCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKX9</accession>
    <name>A0A401PKX9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory factor X-associated protein RFXANK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000739">
        <property type="protein sequence ID" value="GCB73780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKX9"/>
    <dbReference type="STRING" id="75743.A0A401PKX9"/>
    <dbReference type="OMA" id="AKPRKPW"/>
    <dbReference type="OrthoDB" id="10065946at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.290.30">
        <property type="entry name" value="Regulatory factor X-associated C-terminal binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038308">
        <property type="entry name" value="RFXAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029316">
        <property type="entry name" value="RFXAP_RFXANK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15110">
        <property type="entry name" value="REGULATORY FACTOR X-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15110:SF2">
        <property type="entry name" value="REGULATORY FACTOR X-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15289">
        <property type="entry name" value="RFXA_RFXANK_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulatory factor X-associated protein RFXANK-binding" evidence="2">
        <location>
            <begin position="112"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="240" mass="27604" checksum="FAFFF2E29E858E6C" modified="2019-05-08" version="1">MSGSRKNSEEPPTLSPRSVSHQELTTVAMDAACSETSQEGAGGDTLVTPDNRESPGEGEDNNNEEEEDEEDEDDDEEEEEEEDDEDDDDDEDEEEEDEEEEESGHSETVTRKCVYEGCTETTSQVAKPRKPWMCKKHRNKTYKDKYKKRKSDMVNIHKSNDDTDDRPKSATKQRLSCMIVQQTNRKASLLEQVLNQKRLSLLRSPEVVQFLQQQQRLLSNQALAQRQQFQENQCDAFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMJ1</accession>
    <name>A0A401PMJ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear receptor subfamily 4 group A member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0003452</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000937">
        <property type="protein sequence ID" value="GCB74362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMJ1"/>
    <dbReference type="STRING" id="75743.A0A401PMJ1"/>
    <dbReference type="OMA" id="MEISRGW"/>
    <dbReference type="OrthoDB" id="5952118at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021953">
        <property type="term" value="P:central nervous system neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06969">
        <property type="entry name" value="NR_DBD_NGFI-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000008">
        <property type="entry name" value="Nuclear receptor subfamily 4 group A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000009">
        <property type="entry name" value="nuclear receptor subfamily 4 group A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003070">
        <property type="entry name" value="NR4A1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003073">
        <property type="entry name" value="NR4A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF0">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01284">
        <property type="entry name" value="NUCLEARECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01287">
        <property type="entry name" value="NURRNUCRCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="15">
        <location>
            <begin position="277"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="16">
        <location>
            <begin position="377"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB74362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="615" mass="68743" checksum="C15B1A800234B1F5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS74</accession>
    <name>A0A401PS74_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008725">
        <property type="protein sequence ID" value="GCB75947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS74"/>
    <dbReference type="STRING" id="75743.A0A401PS74"/>
    <dbReference type="OrthoDB" id="10670711at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245:SF2">
        <property type="entry name" value="DISINTEGRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="200" mass="19004" checksum="6C9EB6C727C06F68" modified="2019-05-08" version="1">MNISAYAMSVSGADAMSISGDYVMSITGADVMPISGADGMSISGADVMPISGADAMSISGADVMPISGADVMPITGADVMPISGADAMSISGADAMSISGADAISISGADVMPISGAAVMPITGADAMSISGADGMPISGADAMSISGADAVSISGADAMSISGADAMSISYADAMSISGADVLSISGADVMSNSGVLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSQ8</accession>
    <name>A0A401PSQ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleavage stimulation factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cleavage stimulation factor 50 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0019099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts (via repeats WD) directly with CSTF3. Interacts (via repeat WD6) with BARD1. Interacts with ERCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013903">
        <property type="protein sequence ID" value="GCB76169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSQ8"/>
    <dbReference type="STRING" id="75743.A0A401PSQ8"/>
    <dbReference type="OMA" id="DERTISH"/>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.50:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000064">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000089">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.50">
        <property type="entry name" value="Cleavage stimulation factor subunit 1, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032028">
        <property type="entry name" value="CSTF1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038184">
        <property type="entry name" value="CSTF1_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16699">
        <property type="entry name" value="CSTF1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 1 dimerisation" evidence="11">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB76169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="431" mass="48499" checksum="063874995267C03E" modified="2019-05-08" version="1">MFRPKVTLKDRQHLYRLIIGQLLYDGYMNIASNLINEIKPPSVCSPSEQLLHLAKIGMENDDNTVQYAIGRSDTVAPGTGIDMEFDADVQTMSPEAAEYETCYVTSHKGPCRIATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSKDYTLKLFDYSKPSAKRAFKYLQEAEMLRSISFHPSGDYILVGTQHPTLRLYDVNTFQCFVSSNPRDQHTDAVCAVSYNPSANMYVTCSKDGSIKLWDGVSNRCITTYEKAHDGAEVCSIIFSRNSKYVLSSGKDSIVKLWEISTGRTMVKYTGAGLSGRQTHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERKNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT92</accession>
    <name>A0A401PT92_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0021001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017853">
        <property type="protein sequence ID" value="GCB76366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT92"/>
    <dbReference type="STRING" id="75743.A0A401PT92"/>
    <dbReference type="OMA" id="KDLQQGP"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005176">
        <property type="term" value="F:ErbB-2 class receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NIDO" evidence="9">
        <location>
            <begin position="164"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="8">
        <location>
            <begin position="332"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB76366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="60724" checksum="C217CA9F93EBAF88" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTV6</accession>
    <name>A0A401PTV6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanylate cyclase activator 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0019907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the guanylin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015305">
        <property type="protein sequence ID" value="GCB76579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTV6"/>
    <dbReference type="STRING" id="75743.A0A401PTV6"/>
    <dbReference type="OMA" id="ACEICES"/>
    <dbReference type="OrthoDB" id="9926421at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030250">
        <property type="term" value="F:guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1450.10">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000879">
        <property type="entry name" value="Guanylin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036382">
        <property type="entry name" value="Guanylin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11318:SF4">
        <property type="entry name" value="GUANYLATE CYCLASE ACTIVATOR 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11318">
        <property type="entry name" value="GUANYLIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02058">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001849">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00774">
        <property type="entry name" value="GUANYLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89890">
        <property type="entry name" value="Proguanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019243867" description="Guanylate cyclase activator 2B" evidence="9">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="109"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="112"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001849-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB76579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="120" mass="13200" checksum="B3A21757B7ABA828" modified="2019-05-08" version="1" fragment="single">ESSEAKFLTPVSMKTLFAILFLTSCLSSLVENVMVQDGDYEFLLEEVKQLWLLMNKGHLGSTPDADKSQVSTLCKNPELPEVFQPVCVSNDASQVFLRLKELSVKADICEICAYAACSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU90</accession>
    <name>A0A401PU90_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0019177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014008">
        <property type="protein sequence ID" value="GCB76672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU90"/>
    <dbReference type="STRING" id="75743.A0A401PU90"/>
    <dbReference type="OrthoDB" id="8932112at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019488289" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="21692" checksum="AA53A4B1F608BFBA" modified="2019-05-08" version="1">MLLVFLLRVAGVALAAAAVMPPVADVPLAAAGIAPATAGVVVAGVALSAAGIASAAGISLAAAGVAPSAADVAPAAADVAPAAADVAPAAADVALAAARVASSVALAAAGISLAAAGIAPAAAGVAPAVAAVVTAVVAPAAAGVSITETQQSCTMQTNDGDINNCVEVRTVDNKRTKQGLTCHLVIASLVGALGSSFLFGYNLSVVNAPTVVSESKQTKNHFIAHTVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUS5</accession>
    <name>A0A401PUS5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011461">
        <property type="protein sequence ID" value="GCB76868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUS5"/>
    <dbReference type="STRING" id="75743.A0A401PUS5"/>
    <dbReference type="OMA" id="HRKFHEI"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="7944" checksum="A459957EA9D719B9" modified="2019-05-08" version="1" fragment="single">VLPHDAKARRLFVTSGGLKKIQEIKAEPGSVMQEYINGINNCYPEEIVRYYSPGYSDALLERVENYQPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVW1</accession>
    <name>A0A401PVW1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KaiA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011539">
        <property type="protein sequence ID" value="GCB77255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVW1"/>
    <dbReference type="STRING" id="75743.A0A401PVW1"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020856">
        <property type="entry name" value="Circadian_clock_protein_KaiA_C"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51431">
        <property type="entry name" value="KAIA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiA C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9290" checksum="1C75FE0C9E0FEB47" modified="2019-05-08" version="1" fragment="single">VEPFASLSEMVRKSVPRVLFNQDLVGSVARNPLRVNDIVELGDIVGGVKRFSKMLGWNKEINDLLTREHEKLERDNIERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWN0</accession>
    <name>A0A401PWN0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0017617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011603">
        <property type="protein sequence ID" value="GCB77564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWN0"/>
    <dbReference type="STRING" id="75743.A0A401PWN0"/>
    <dbReference type="OMA" id="LYISFDP"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="481"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB77564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="599" mass="67651" checksum="D796FE0AFC75DE77" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX77</accession>
    <name>A0A401PX77_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0017645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011631">
        <property type="protein sequence ID" value="GCB77708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX77"/>
    <dbReference type="STRING" id="75743.A0A401PX77"/>
    <dbReference type="OMA" id="LLETIDX"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000003">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="336"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB77708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="674" mass="78453" checksum="8840F2FB41C6667C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXH8</accession>
    <name>A0A401PXH8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0021139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018212">
        <property type="protein sequence ID" value="GCB77841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXH8"/>
    <dbReference type="STRING" id="75743.A0A401PXH8"/>
    <dbReference type="OMA" id="YWKAENV"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19762">
        <property type="entry name" value="Bbox2_TRIM7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
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        <property type="entry name" value="ZF_RING_2"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
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    <feature type="coiled-coil region" evidence="5">
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            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB77841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="215" mass="24576" checksum="74140730F2AEF16D" modified="2019-05-08" version="1" fragment="single">MRDEAICPICLDFFTHPVTIDCGHNFCQGCILGYWAPQRGKVSCPQCRRQFTQRNVRPNHFVSNIVAGVRQLSLDGGQAGAGTEPLCLEHGEELKLFCQEDQRAICVVCSLSRDHKPHTVSPIKEAADLYKQQAKGLRKNIASKFDQLHQFLHQEEKDLKTKLQQNEESILQKIKENLNKISEQQVAFERTLTEMQRRLTLQEAEFLKGINCILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZB1</accession>
    <name>A0A401PZB1_SCYTO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013123">
        <property type="protein sequence ID" value="GCB78475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PZB1"/>
    <dbReference type="OrthoDB" id="6146069at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090160">
        <property type="term" value="P:Golgi to lysosome transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034592">
        <property type="entry name" value="CCDC91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35072">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35072:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="292" mass="32889" checksum="A66AE1EC7DFD38B1" modified="2019-05-08" version="1" fragment="single">VKFKLIIKNDFTFQIQVQPSVDFAPVPTSSQEIDPQQSASADVLVGHVVPKETNKMEACYKESLENMEAKLSAAEEEKLRIKEELQEMFEKYSKLEEHLQEKKAEEISYEDHYNQLQEKHKLELEDLRKAGHDALSIIIEEFKALTKSAVQQQQEASKKQLQSAIENQMQKCEELLNTQDYVTVNQINQLYSSSKTNCPPDSVAESPEAIAEAPSPQQQSKLLPPCLGRDSPSELSSRPVPKPPAVHWPDDVVPSVDAALPPPPPLPAKKHSRRNQVMSQCVSFCYHSVKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q014</accession>
    <name>A0A401Q014_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maestro heat-like repeat-containing protein family member 1</fullName>
        </recommendedName>
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    </gene>
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        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011829">
        <property type="protein sequence ID" value="GCB78680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="INMVPLY"/>
    <dbReference type="OrthoDB" id="1884734at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="4">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="3">
        <location>
            <begin position="243"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="2">
        <location>
            <begin position="930"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB78680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1452" mass="163355" checksum="316FF5FDF36F3589" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0G8</accession>
    <name>A0A401Q0G8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014521">
        <property type="protein sequence ID" value="GCB78897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0G8"/>
    <dbReference type="STRING" id="75743.A0A401Q0G8"/>
    <dbReference type="OMA" id="DAFMERS"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000133">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000191">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="363" mass="41418" checksum="3F39D16F9BDFB0E7" modified="2019-05-08" version="1" fragment="single">LERYEDCLSVYRDLIRNSQDEYEEERKTNLSAVVAALSTWENLFPDDLGLPETSYELCYNAACTLIGEGKLPQAMNKLQKAEELCRQSYSEDTDMSDEEIDAELAIIHAQMAYIMQLQGRSDDALQLYNQVIKLKPSDVGLLAVTANNIITLNKDQNVFDSKKKVKLTNTEGVEHKLTQKQMQTVEFNKALLAMHTNQADQCRKLTLGLQKQNPESPLPVLIQAAQLCREKQHTKAIQLLQEFLEQHPENAVEIKMTIAQLYLVQGHVTKACDILKSIDEKLNKLGMVSALVTMYSHEEDIDSAIEIFCQAIQWYQEHQPNTPAHLSLVREAANFKLKYGRQKEAISDLEQLWRIIGVIEHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q130</accession>
    <name>A0A401Q130_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011913">
        <property type="protein sequence ID" value="GCB79050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q130"/>
    <dbReference type="STRING" id="75743.A0A401Q130"/>
    <dbReference type="OrthoDB" id="5961210at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="1">
        <location>
            <begin position="130"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="251" mass="28466" checksum="F1980B11BDC37B8D" modified="2019-05-08" version="1" fragment="single">MRGMLSNQLGLLPNQLGDVQSALGVLSKELGMLSNQLRVLSNQLGVLPNQLGVLPNQLRVISNQPGLMSNQLRVLSNQLEYLHLPSYPLLWAPEYLDLCQIMILHERNTMNAQFIRHPVTQQLPSIWSNLDLGSDGGYSGSSWHHIHPQLWTKYQVWEWLQHTLDINQLDANCVRFQDFDVTGEQLCSMTIEHFTQTTGHLGPLLFDNLRSFKQNSKHLSSNGQPLMAEQRGTFINSMLFPVNVMVKSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q131</accession>
    <name>A0A401Q131_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014566">
        <property type="protein sequence ID" value="GCB79064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q131"/>
    <dbReference type="STRING" id="75743.A0A401Q131"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="9867" checksum="02C921685B835E87" modified="2019-05-08" version="1" fragment="single">MARGVCTSRRNLEPIWKKRTLEETAKCWISGIALIVVGILVQTKVNGTLHITNVAASGAPIVIIIVGVVINFVAFFGCCGAWKENYCMVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1I3</accession>
    <name>A0A401Q1I3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011949">
        <property type="protein sequence ID" value="GCB79208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1I3"/>
    <dbReference type="OMA" id="MVFTVFM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="602" mass="72765" checksum="3DB7238068C2BE06" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1I8</accession>
    <name>A0A401Q1I8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011955">
        <property type="protein sequence ID" value="GCB79242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1I8"/>
    <dbReference type="STRING" id="75743.A0A401Q1I8"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF1">
        <property type="entry name" value="CELL ADHESION MOLECULE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="100" mass="11018" checksum="9C01672DD99C2545" modified="2019-05-08" version="1" fragment="single">LRDNRIELVRSSWHELSINISDVTLSDEGQYTCSLFTMPVKTAKAFLIVLGVPQTPVISGFKGPVNEGVLVELTCTTIGSKPAANIRWFKGDKEIRGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2B6</accession>
    <name>A0A401Q2B6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014672">
        <property type="protein sequence ID" value="GCB79508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2B6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="9533" checksum="CFF8AD115B1EEC13" modified="2019-05-08" version="1">MSTFRSLGNVFFVSNLCSEKISREILKSIKCSPFKNNSIWFRVGNIRRSINRETRASYVISPISTRKLRIRCLPFDSMVDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2S1</accession>
    <name>A0A401Q2S1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012059">
        <property type="protein sequence ID" value="GCB79692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2S1"/>
    <dbReference type="OrthoDB" id="7479158at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8739" checksum="241AA875CDE86DE5" modified="2019-05-08" version="1">MELDRLGLVSMELDRLGLIPMELDRLELISMELDRLGLIPMELDILGLVSMELDRLGFIPMELDRLGLISMELDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4I1</accession>
    <name>A0A401Q4I1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0018061</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts (via Sushi domain 21) with ITGA9:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction. Interacts (via Sushi domain 21) with ITGA4:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction. Interacts with ANGPT1 and ANGPT2. Interacts with PEAR1 (via extracellular domain). Interacts with HSPG2, TLN1, FN1, COPA, CCT2, IQGAP1, LAMC1 and NID1. Interacts (via C-terminus) with TIE1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012249">
        <property type="protein sequence ID" value="GCB80282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401Q4I1"/>
    <dbReference type="OMA" id="ITCNRPD"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003013">
        <property type="term" value="P:circulatory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010572">
        <property type="term" value="P:positive regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000011">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000327">
        <property type="entry name" value="neurogenic locus notch homolog protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000012">
        <property type="entry name" value="neuronal pentraxin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50923"/>
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        <source>
            <dbReference type="PROSITE" id="PS51828"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2109" mass="228331" checksum="ABDD5B4E941A14A1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5S9</accession>
    <name>A0A401Q5S9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0016350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009831">
        <property type="protein sequence ID" value="GCB80711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401Q5S9"/>
    <dbReference type="OMA" id="MCPAAVQ"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015701">
        <property type="term" value="P:bicarbonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000020">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018241">
        <property type="entry name" value="Anion_exchange_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF15">
        <property type="entry name" value="ANION EXCHANGE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00219">
        <property type="entry name" value="ANION_EXCHANGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="13">
        <location>
            <begin position="5"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="12">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="12">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="12">
        <location>
            <begin position="388"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB80711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="739" mass="84137" checksum="047786CF59B60F86" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5V5</accession>
    <name>A0A401Q5V5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leprecan-like alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0016371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leprecan family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009855">
        <property type="protein sequence ID" value="GCB80732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5V5"/>
    <dbReference type="STRING" id="75743.A0A401Q5V5"/>
    <dbReference type="OMA" id="EAFCGRN"/>
    <dbReference type="OrthoDB" id="8610171at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052284">
        <property type="entry name" value="Collagen_mod_leprecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986:SF4">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN SC65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986">
        <property type="entry name" value="PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019319870" description="Leprecan-like alpha-helical domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Leprecan-like alpha-helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB80732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="458" mass="53741" checksum="B92EA263395276A7" modified="2019-05-08" version="1">MERPGSCSVTGALLLLSALLPGAGGQYEKYSVRSFPESELIPLDSAYRYSLEQYTAGNWRESIRYLELSLRVHRLLRESQLHCHTDCSRAEPEDRQLPRAEPEDRQLPRAEPEDRQLPRAEPEDRQLLRELRQFSRILHHAVCIKSCKRSLPVFKLTSPHTETLHLFERRIPYKYLENAYFEINNLEKSIAAAHTFLQKNPKDAAMQKKMAYYKTIPDIETYLVDVEAREHETLFLKAVKAYNIGNFRNSITEMEHALPEYYKVYEECISGCEASCDVTGFKDFYLAVADHYVETLKCKVKCEQILTPNVGGFFVEKFVATMYHYLQFAYYKLNDIKNAVSCVATYMLFDPQDEIMQQNLVYYRFYREQWSLQEEDFQPRTDAHLYYNQTRLQIQLLEFADNFLQSDDEMEVSDETFSHSEAEVTDEEFEGDGDYEENILADWWQESRKKGDLDDAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6R0</accession>
    <name>A0A401Q6R0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023833">
        <property type="protein sequence ID" value="GCB81017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6R0"/>
    <dbReference type="STRING" id="75743.A0A401Q6R0"/>
    <dbReference type="OMA" id="AILXVER"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF107">
        <property type="entry name" value="DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="189" mass="21020" checksum="A8684313BEEC8421" modified="2019-05-08" version="1" fragment="single">FLYSELLKYDPASPADSLFTPAQDNRLQIKPGITFHLYISTAPCGDGALFDKSCSEPPTKEGDESHHPLFENMKQGKLRTKVENGEGTIPVESSDIVPTWDGIQHGERLRTMSCSDKILRWNVLGLQGALLSHFIHPVYLSSVTLGYLYSHGHLARAVCCRMSRDGEEFQKGLPYPYTLNHPQVTTSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q705</accession>
    <name>A0A401Q705_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026524">
        <property type="protein sequence ID" value="GCB81150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q705"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="127" mass="15249" checksum="EC64C0BF553126E6" modified="2019-05-08" version="1">MSMRMYKDIDNEHKGIDDENEDIDNKNKDIHGEYEGIDDEHKGIDDEYEDIDDQNEDIDGEYESIDDEFESIDDEFESIDDEYDDIDGEYEDIDNEYEDIDDEYEETMRTHPKNMNMMKKMTTLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7B0</accession>
    <name>A0A401Q7B0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol transfer protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020073">
        <property type="protein sequence ID" value="GCB81251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7B0"/>
    <dbReference type="STRING" id="75743.A0A401Q7B0"/>
    <dbReference type="OMA" id="NDKIHNT"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="14262" checksum="E9A12295829093DB" modified="2019-05-08" version="1" fragment="single">SRLTVDLSSFQDYKPEEDPAIYKSVKTGRGKLGTSWKKELAKRRDWPHMCAYKLVTVKFKWWGLQNKVESFIQKQERRLFTVFHRQLFCWMDRWIGLTMDDIRRMEDDTKKELDEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q817</accession>
    <name>A0A401Q817_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0021413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018946">
        <property type="protein sequence ID" value="GCB81525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q817"/>
    <dbReference type="STRING" id="75743.A0A401Q817"/>
    <dbReference type="OMA" id="DGMGTTC"/>
    <dbReference type="OrthoDB" id="6361633at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03156">
        <property type="entry name" value="uroplakin_I_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47110">
        <property type="entry name" value="TESTIS-SPECIFIC EXPRESSED PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47110:SF2">
        <property type="entry name" value="UROPLAKIN-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27672" checksum="D6F7A2801A3A0F56" modified="2019-05-08" version="1" fragment="single">VKLDSGGSRCERLASIALFAETIWVVTDQFRIYPVLGASGKDDVFAGAWIAIFAGFAFFCLSVFGILAVLSESRTMVITYLVLMIIVYIFEAASCITAITHRDYLTSNPKFVKKQMLQFYGDTSTNSGRDLTVMWNRVMQQEQCCGSTGPMDWIKYTSFFRSQFNETTAPWPFQCCKRDMNSEIANQEGCVVGHRDFLYQKGCFDYFSTSINSYAWGVAWFGFAILMWTFVVLLMTMYYLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q894</accession>
    <name>A0A401Q894_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">trypsin</fullName>
            <ecNumber evidence="10">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0021428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01018983">
        <property type="protein sequence ID" value="GCB81590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q894"/>
    <dbReference type="STRING" id="75743.A0A401Q894"/>
    <dbReference type="OMA" id="FPPGERC"/>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000008">
        <property type="entry name" value="Cationic trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000122">
        <property type="entry name" value="Chymotrypsin-like elastase family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000166">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF68">
        <property type="entry name" value="TRYPSIN-3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0222">Digestion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="219"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB81590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="444" mass="49223" checksum="6FE3373D39A1CDDA" modified="2019-05-08" version="1">MEGDVVSAVSCYRDDKIVGGYECIPHSVPYQVYMRRYQSPWCGASLLNSQWILSAAHCFLRPSLLNVWIGAHDLSVSEDSRQSRRVIRAVRHPGYDHRTTDNDIMLLKVAPPVQFNEKVQPLQMPSSCASNGTECRVAGWGDTVHDGGQFPDRLQCLDVPILSDTECESSYGDAITPNMFCAGFLEGGKETCQVTALGKSSFITELTGAAVAAPVDEKIINGHECYAHSQPWQVFLTYNGYRWCGGSLIDHQWIVSAAHCYQPPSILKAHLGEHDLGYYEGTEQRIPVAKAFAHPDYNRVNLNNDIMLLKLAYPARLDQYVRLIPLPSQCPRAGTQCITSGWGNLVTNGVKYPNALQCLNQPILPDADCRRAYPPYFTDNMFCSGYWEGGQSTCQGDSGGPVVCDGELQGITSWGYDCAMKNHPSVFVKVCNYNQWIQEIIAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8K2</accession>
    <name>A0A401Q8K2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025592">
        <property type="protein sequence ID" value="GCB81719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8K2"/>
    <dbReference type="STRING" id="75743.A0A401Q8K2"/>
    <dbReference type="OrthoDB" id="25840at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="171" mass="17751" checksum="A81964C2D27B8261" modified="2019-05-08" version="1" fragment="single">SLAYGLSFIRFYSTPEDIETSPGSSSPKITKLGQFVVKEEEGSGNSLKPGSLFFSRASRPQLSPPTAVAAPSQSDKPTASYAAAALQASGVASPSSSFVPKEKSAAKPGLGASSPKPLTLGKRKFDFAKERMGGLPVKKESPGEGSESSSKKTSPLPSAAKKFKGRRASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9K2</accession>
    <name>A0A401Q9K2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020566">
        <property type="protein sequence ID" value="GCB82052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9K2"/>
    <dbReference type="STRING" id="75743.A0A401Q9K2"/>
    <dbReference type="OMA" id="EIICRTV"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000013">
        <property type="entry name" value="Collagen, type I, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019448897" description="VWFC domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10240" checksum="687A8A3BF31E1EE5" modified="2019-05-08" version="1" fragment="single">MFRFVDSRTLVLLTATQAILLAVVKCQGADIQDLKVNCMQEGQTYSDKDVWKPEPCRICVCDAGIILCDEIICEDLKDCPNPEIPFGECCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9T6</accession>
    <name>A0A401Q9T6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0021946</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Elbow/Noc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020620">
        <property type="protein sequence ID" value="GCB82149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9T6"/>
    <dbReference type="OMA" id="LMYPSPH"/>
    <dbReference type="OrthoDB" id="10054079at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000129">
        <property type="entry name" value="Zinc finger protein 503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051520">
        <property type="entry name" value="Elbow/Noc_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022129">
        <property type="entry name" value="Tscrpt_rep_NocA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522">
        <property type="entry name" value="ZINC-FINGER PROTEIN NOLZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12402">
        <property type="entry name" value="nlz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB82149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="516" mass="53957" checksum="72F3BD250BB81ABF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9X9</accession>
    <name>A0A401Q9X9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RasGAP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024570">
        <property type="protein sequence ID" value="GCB82127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9X9"/>
    <dbReference type="STRING" id="75743.A0A401Q9X9"/>
    <dbReference type="OrthoDB" id="9302601at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF10">
        <property type="entry name" value="RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RasGAP protein C-terminal" evidence="1">
        <location>
            <begin position="77"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="167" mass="18572" checksum="D96A6BFD9930F4D1" modified="2019-05-08" version="1" fragment="single">DSLMPEHGDPLHELLKDLGDIPTVESLLGEGSVDANDPHADQTLSQLNKTEVSLTLTNKFDLDKSDDGANNTRGLLLRQQRKAELNKLRATLHRMDSKTAFYEEQIDYYQQYIRTCLDNLATKAPGPGKKAAEVKGKKRKVPSLNYTAARLQEKGVLLDIEDLPGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCP3</accession>
    <name>A0A401QCP3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030461">
        <property type="protein sequence ID" value="GCB83150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCP3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="56" mass="5891" checksum="C010502C7D664C01" modified="2019-05-08" version="1" fragment="single">FVVVLAVFVVAVVVLVSAVLLVVFVVLVALHVVFVLAVVVLVSAVILVVFVFLDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD68</accession>
    <name>A0A401QD68_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029512">
        <property type="protein sequence ID" value="GCB83329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD68"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7476" checksum="F7E7E160166F4431" modified="2019-05-08" version="1" fragment="single">VVLEKDDTKTKEKTAVKRVAEHSAAEPECKVQKSETAPSTDIEPVTGKHLFDLFIILFFLSIDGIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFC0</accession>
    <name>A0A401QFC0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01051833">
        <property type="protein sequence ID" value="GCB84079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFC0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="480" mass="56082" checksum="4D81E0B0CC05AA24" modified="2019-05-08" version="1" fragment="single">DPDAEYRETLHSNPDTEYTEMLYCNPDPEYTETLYCNPDPEYTETLYIDPDPEYTENLYSNPDPEYRESLYSNPVTEYTEILNTHPDPEYRESLYSILTLNTQGFCTVFLTLTTQRLCTVILTLNTDRLFTVIMTVHTQRLCTVILMLNTQRLCTVILTLNTQKYCSNPDPDYTETPYSNHDSEYTGAPYNNLYCNPDPEYTEILYCNPNPENTETLSSNPDPEYTDTLYSNPDPEYTETRYSDTDPQYTETLYSNPHTEYTETLYGGHDPEYRESLDPDAEYRETLHSNPDPEYTEIRYCNPDPEYTETLYCNPDPEYTETLYSNPDPEYTETLYSDPDPEYTENLYSNPDPEYRESLYSKPDPEYTEILYSNPYTECTEILYCNPNPEYTETLCSKPDPEYTDTLYSNPDPEYTETLSSDPDPEHTETQDSDTDPEYTEILYRDPNPEYTETLSSNPGTEYTETLCSEPDPEYTVSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFE0</accession>
    <name>A0A401QFE0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01055741">
        <property type="protein sequence ID" value="GCB84086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFE0"/>
    <dbReference type="STRING" id="75743.A0A401QFE0"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF54">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB84086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="9616" checksum="31AEA38D3CA3E262" modified="2019-05-08" version="1" fragment="single">MDYSLLVGVHNMDTASRERLSEGLLGGTDTRRPVGQRALYSTAVEAIQGESRLGGTGDTDELMGGIPARNSKGERLMLYIGIIDILQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFK7</accession>
    <name>A0A401QFK7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01052149">
        <property type="protein sequence ID" value="GCB84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFK7"/>
    <dbReference type="OMA" id="SDWFQEM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="166" mass="19161" checksum="561B0C2884A19845" modified="2019-05-08" version="1">MQQLVGWFTGLMQQLIWFGYSLMQWLVGLVYWFNAAVGLVYWCNAAVGLVYWFNAAVGLVYWFNAAVGLVYWFNAAVGLVYWFNAAVGLVYWFNAAVGWFTGLTQRLDWFTGLTQRLDWFTGLTQWLDWFTGLTQRLDWFTGLTQRLVGLGYLQIIMAAGAKLRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFR5</accession>
    <name>A0A401QFR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01062427">
        <property type="protein sequence ID" value="GCB84225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFR5"/>
    <dbReference type="OMA" id="WRREREN"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="20646" checksum="AA160A0D1B212155" modified="2019-05-08" version="1" fragment="single">QRQRETERDRESQRDIERERETERDREREIEIEMEGQRDRQRYNDRERQRDWDRERETERLSQRERQRQRDRERDRETERQRQRETERERQRQRHRERDRDTERETERERGRDREREKKRETERETHREMTERETDRERERQRERDRQRDRDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG65</accession>
    <name>A0A401QG65_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">IMP dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0024945</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01062918">
        <property type="protein sequence ID" value="GCB84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG65"/>
    <dbReference type="STRING" id="75743.A0A401QG65"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000424">
        <property type="entry name" value="Inosine-5'-monophosphate dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF121">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 16" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="17">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="11605" checksum="0FDDEACB94C12E23" modified="2019-05-08" version="1" fragment="single">LMGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVMSPSEKVQDVFEAKARHGFCGIPITDTGKLGGKLVGIISSRDIDFLTEKEHDRYLAEVLPGEGGVGAMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QID9</accession>
    <name>A0A401QID9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01127273">
        <property type="protein sequence ID" value="GCB85112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QID9"/>
    <dbReference type="OrthoDB" id="9446605at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="11941" checksum="FA504575E8BD6F0F" modified="2019-05-08" version="1" fragment="single">VQESFAKNNMACLTEDILHPHAGPKGGEEFYGDPTREKTERNEDLCWKFRAQIQQLIEKTISNQYEQDMSVIVKGKYILTAWIDIFSKKCLRFDRFASVLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIU0</accession>
    <name>A0A401QIU0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01148222">
        <property type="protein sequence ID" value="GCB85291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIU0"/>
    <dbReference type="STRING" id="75743.A0A401QIU0"/>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="14750" checksum="11C5F393BD9B7F36" modified="2019-05-08" version="1">MSLRFEDQLEADIEDMLESYLKFNRSKNVFSFVRTPATMLTLMISMHIASGFLSLLGLGFLTFILSFANGICSLTLITWCYVKYTGQSPLLGEIIDAISDSILSGVTSLIVSRYLNPEQVTMVAGLAHASRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJN1</accession>
    <name>A0A401QJN1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01169194">
        <property type="protein sequence ID" value="GCB85574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJN1"/>
    <dbReference type="OMA" id="MCASVRV"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="50" mass="5596" checksum="AF32AFC06CA110AE" modified="2019-05-08" version="1" fragment="single">MCASVRVCVRPYVCAFVRVRSYVRVCVRMCVCTCVRACGVRTCVGYVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJY8</accession>
    <name>A0A401QJY8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01181246">
        <property type="protein sequence ID" value="GCB85628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJY8"/>
    <dbReference type="OMA" id="YTNIELC"/>
    <dbReference type="OrthoDB" id="10660170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="290" mass="33182" checksum="9C9224CCA31B062F" modified="2019-05-08" version="1" fragment="single">LYTNIELCVTPLYTNIELCVNPLYTNIELCVIPLYTNFELCATPLYTNIELCVIPLYTNIELCVIPLYTNIELGVMPLYTNIELCVIPLYTNIEPCVMPLYTNIELCVIPLYTNIELCVTPLYTNIELCSPLYTNIELCVTPLYINIELCETPLYTNIELCVPPLYTNIELCVTPLYTNIELCETLLYTNIELCVNPLYTNIELCATPLYTNIELCVTPLHTNIELCVMPVHTNIELRVIPLYTNIELRVIPLYTNIEPCVTPLYTNIEPCVTPLYTNIELCVMPLYTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLY2</accession>
    <name>A0A401QLY2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01287760">
        <property type="protein sequence ID" value="GCB86389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLY2"/>
    <dbReference type="STRING" id="75743.A0A401QLY2"/>
    <dbReference type="OMA" id="HTTYLST"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="290" mass="30981" checksum="CE1BA1ABFF864429" modified="2019-05-08" version="1" fragment="single">PLPGTVVRLTLPDTVVRWTLPDTVVLLTLPHTVVLLTLPETVVLLTLPGTVVLLILPDTVVLLTLTETVILLTLPHTVVLLTLPDTVVLLTLPHTVVRVTLPDTVVVLTLPDTVVLVTLPDTVILLTLPGTVILLTLPGTVVLMILPDTVVLLTLPDTVVLLTLPDTVVRVTLPDTVVLQTLPDTVVLLTSPDTVVLLTLPHTVVRVTLPDTVVLQTLPDTVILLALPDTVILLTLPDTVVLLTSPDTVVLLTLPHTVVRVTLPHTVVRVTLPDTVVLQTLPDTVVLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMI0</accession>
    <name>A0A401QMI0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01314592">
        <property type="protein sequence ID" value="GCB86586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMI0"/>
    <dbReference type="STRING" id="75743.A0A401QMI0"/>
    <dbReference type="OMA" id="EPRVNTD"/>
    <dbReference type="OrthoDB" id="7482953at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="268" mass="30246" checksum="86A5D5465F19830A" modified="2019-05-08" version="1" fragment="single">TPELRVNTDTPELRVNTDTPGLRVNTVTPEPRVNTDTPEQRVNTETPELRVNTDTPELRVNTVTPELRVNADTPGLSVNTDTPELRVNAETPELRVNAETPELRVNTDTPEPRLNTDTPEMRVNTDTPEPRVNTDTPEPRVNTDTPELRVNTVTPELRVNSDTPELRVNADIPELRVNTDTPEPRVNTDTPELRVNTDTSEPRVNTDTPELRVNTDTPELRVNTDTSELRVNTDSPELRVNTDTPERRVNTDTPELRVNTDTSESKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPD7</accession>
    <name>A0A401QPD7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01437299">
        <property type="protein sequence ID" value="GCB87244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPD7"/>
    <dbReference type="STRING" id="75743.A0A401QPD7"/>
    <dbReference type="OMA" id="WILEWIL"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="9747" checksum="718CBF7755181FDA" modified="2019-05-08" version="1" fragment="single">FNGYLNGSLNGFLNGLLNGSLTGYLNGSLNGSLNGFLNGFLNGLLNGSLTGYLNGYLNGFLNGSWIPELILERIPEWIPEWILEWILDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPL9</accession>
    <name>A0A401QPL9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0027992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Chordata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01445607">
        <property type="protein sequence ID" value="GCB87282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPL9"/>
    <dbReference type="STRING" id="75743.A0A401QPL9"/>
    <dbReference type="OMA" id="VQMAGMP"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB87282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9281" checksum="8F0FE54C05976204" modified="2019-05-08" version="1" fragment="single">NTINQTPVTLQVPGLVSTQVQMAGMPTEILCLMNMITPDELVDDEEYEEIVEDVREECSKYGMVKSIEIPRPIDGLEVPGCGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGS4</accession>
    <name>A0A401NGS4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptor 83</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0006817</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002365">
        <property type="protein sequence ID" value="GCB60127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGS4"/>
    <dbReference type="STRING" id="75743.A0A401NGS4"/>
    <dbReference type="OMA" id="ITMQQYI"/>
    <dbReference type="OrthoDB" id="5952899at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15389">
        <property type="entry name" value="7tmA_GPR83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000191">
        <property type="entry name" value="Probable G-protein coupled receptor 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF69">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="88"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB60127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="421" mass="48466" checksum="98619B5A3D9476A2" modified="2019-05-08" version="1">MSRYLWLPLPYVTSSFRRSSEEGNGSDFFSALYGLSNTSAFFNWRNLTIDDWGVFSNHTKYEAESQNPTVKALLIVAYSVIIVISLFGNVLVCQVVVKNKRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSSWVFGKLMCHVSRFAQYCSVHVSVLTLTAIALDRHQVIMHPLKPRMSTAKGVICIIVIWIMATCFSLPHAIYQKLFRVEYRKEKVRSLCLHNFPQPADLYWKYMDLSTFILLYVLPLLIISVAYTTVAKKLWLRNAIGDITLEQYFAHRRKKIMTLKMLMLVVVVFAVCWFPLNCYVVLISSKAINTNNATYFVFHWVAMSSTCYNPFIYCWLNASFRAELKSLLDICKRRRTAHAQPLPYTSPPYRQAWIEGRNHKRIDLGQNLRFNTNSARTDISIVEPIVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGX4</accession>
    <name>A0A401NGX4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004902">
        <property type="protein sequence ID" value="GCB60024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGX4"/>
    <dbReference type="STRING" id="75743.A0A401NGX4"/>
    <dbReference type="OMA" id="HYPGGWK"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019528260" description="Rhodanese domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="67"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB60024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19210" checksum="8EF80276C17BAC25" modified="2019-05-08" version="1">MPRALGFISALLLRTAIRGWAAEVCRQDRNQRLLSWAPFYLSQSSSYRSICTAPSESVTYQELKQMLKSNTIVIDVRESWEIKEYGQIPGSINVPLGQVEQALKLKPSKFMETYNGKMPSTSDKIVFSCLAGIRSKAALDAAVSMGYSRALHFPGGWEEWVRQEFSEKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHA9</accession>
    <name>A0A401NHA9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heparan-alpha-glucosaminide N-acetyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0011100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004935">
        <property type="protein sequence ID" value="GCB60256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHA9"/>
    <dbReference type="STRING" id="75743.A0A401NHA9"/>
    <dbReference type="OMA" id="ITIYCGH"/>
    <dbReference type="OrthoDB" id="2149840at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF37">
        <property type="entry name" value="HEPARAN-ALPHA-GLUCOSAMINIDE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic" evidence="3">
        <location>
            <begin position="284"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB60256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="680" mass="76530" checksum="5CDD61414061EA86" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIB0</accession>
    <name>A0A401NIB0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YdjC deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006272">
        <property type="protein sequence ID" value="GCB60597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIB0"/>
    <dbReference type="STRING" id="75743.A0A401NIB0"/>
    <dbReference type="OMA" id="SMSADRF"/>
    <dbReference type="OrthoDB" id="8908051at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609:SF1">
        <property type="entry name" value="CARBOHYDRATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="YDJC DEACETYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="27357" checksum="1B968C9465DAD20C" modified="2019-05-08" version="1">MPQPTVRLIVTGDDFGYCLRRNRGCHIGNKVDQELRGQVDLFCELTGHLPHHMDGHQHVHVLPGIRDIFAQVLSDFGIKYTRVPIEPGLHDCDWIGQQLMEFYLQVEKDAFNSIDVFRRHGIRWTDIYIGLTTMGENMSISNIQRVIENAIATRKVKQHLDISCGKKFRSLQDDAILTMELMVHPGYCSFPEEGGCGEGPDEFSMSADRFHELQTLKESKLLKYYEDKNIQLCSFKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ50</accession>
    <name>A0A401NJ50_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001149">
        <property type="protein sequence ID" value="GCB60898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ50"/>
    <dbReference type="STRING" id="75743.A0A401NJ50"/>
    <dbReference type="OMA" id="GHTMHPM"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090537">
        <property type="term" value="C:CERF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029614">
        <property type="entry name" value="CECR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092:SF1">
        <property type="entry name" value="CHROMATIN REMODELING REGULATOR CECR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="995" mass="110840" checksum="1AEBA34AEE74EA93" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKS0</accession>
    <name>A0A401NKS0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006398">
        <property type="protein sequence ID" value="GCB61460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKS0"/>
    <dbReference type="STRING" id="75743.A0A401NKS0"/>
    <dbReference type="OMA" id="LAHESYF"/>
    <dbReference type="OrthoDB" id="10012954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016250">
        <property type="term" value="F:N-sulfoglucosamine sulfohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006027">
        <property type="term" value="P:glycosaminoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB61460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="353" mass="40591" checksum="368D4E204FEA5170" modified="2019-05-08" version="1">MCSSSLPMTLALRLRPFFLYVAFHDPHRCGHSHPQYGPFCEKFGNGESGMGWIPDWQPQHYTSEQVTVPHFVPDTPASRADLAAQYTTISRLDQGIGLVLSELREAGHGNDTLVIYSSDNGIPFPNGRTNLYHAGIAEPMLVHSPEHTARWGQVSQSYVSLLDITPTVLDWFSIPYPTYSIFGKDKVVQLTGRSILPALVCEQPWSTAFSSQSHHEVTMYYPMRAVHSLQYRLVHNIQFKMPFPIDQDFYLSPTFQDLLNRTQSSRPTHWEKSLQEYYYRERWELFNAQENPSETRNLASDPRYAGVLARMKGQLKKWQWLTDDPWVCAPDGVLEDQGPYKFNPECRPLYNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NL70</accession>
    <name>A0A401NL70_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0009379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003812">
        <property type="protein sequence ID" value="GCB61661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NL70"/>
    <dbReference type="STRING" id="75743.A0A401NL70"/>
    <dbReference type="OMA" id="HQVCHFL"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB61661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="7584" checksum="7078191A73309830" modified="2019-05-08" version="1">MSVAANLSASRKMVQQLRCELDIKRLKVSQAATDLKQFCLQNAQHDPLLTGIHPNTNPFRPAKPCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLY2</accession>
    <name>A0A401NLY2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003844">
        <property type="protein sequence ID" value="GCB61895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLY2"/>
    <dbReference type="STRING" id="75743.A0A401NLY2"/>
    <dbReference type="OrthoDB" id="2129492at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF0">
        <property type="entry name" value="DUF4515 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="153" mass="18154" checksum="F98327D12790AB6B" modified="2019-05-08" version="1" fragment="single">EAVCCLIEHIESIKVENQQLREVLVCLIRRSRVLREQQEELEAQHKQLLQEKDYCSKLRTLRYRKHLSDYVEPKVMELPKVEEEPEIKELPKVKVEPVMKEQPKVKDEPESEESSETKEELTLEEQEDNDLDDDDLDSDDDDDDDDDDDLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNW5</accession>
    <name>A0A401NNW5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0014508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007809">
        <property type="protein sequence ID" value="GCB62552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNW5"/>
    <dbReference type="STRING" id="75743.A0A401NNW5"/>
    <dbReference type="OMA" id="LHGHEAF"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF327">
        <property type="entry name" value="PROTEIN CBG16280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="246" mass="26802" checksum="199B0CCF7E81501F" modified="2019-05-08" version="1">MSKPADHVKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLLKKDKFAFPMPYLADQDGIKSAALSASVLPDSLLTSAEKARLFFPHATASPYSLFEASHLGSKMSEISPSSLSSLQYASPLAYQSGVSAAAAAAAAAAAAAAFGGGHTHTHPSPGNPGYMLPCNCTAWPPSGLQPPLAYILLPGMSKPTLEPYPAYAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPX6</accession>
    <name>A0A401NPX6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heme-binding protein soul5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002618">
        <property type="protein sequence ID" value="GCB62892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPX6"/>
    <dbReference type="STRING" id="75743.A0A401NPX6"/>
    <dbReference type="OMA" id="FIQGANM"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019510605" description="Heme-binding protein soul5" evidence="2">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB62892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24991" checksum="45E3C9FD37BBD73C" modified="2019-05-08" version="1">MEAPTMHCAGLIIFLLLGLTEAGVSYSKPAQCKEVNECFSYDLVCETPDYEVRHYNASKWVATNITSLIMEFAGYQGFTRIFQYIQGNNAEGKHINMTAPVLLQIPQNEGIMEFKNYIIYFLLPADYQQSPPAPTDANIYFIDFPDMYTYVKSFSGWLLAWNSKLNASKLRQQLNNAGEHYDSNYYYGACYNSPKTLVDRHNEVWYIAEGAPVCPKHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ34</accession>
    <name>A0A401NQ34_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0011546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005284">
        <property type="protein sequence ID" value="GCB62952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQ34"/>
    <dbReference type="STRING" id="75743.A0A401NQ34"/>
    <dbReference type="OMA" id="RERNICF"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB62952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="450" mass="50407" checksum="672A808FC33A17BE" modified="2019-05-08" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSLKYVPRAILVDLEPGTMDSVRSGPFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGKMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQT1</accession>
    <name>A0A401NQT1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0014601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007894">
        <property type="protein sequence ID" value="GCB63230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQT1"/>
    <dbReference type="STRING" id="75743.A0A401NQT1"/>
    <dbReference type="OMA" id="RAFCSHA"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057439">
        <property type="entry name" value="ANG-1/2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25443">
        <property type="entry name" value="ANG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="9">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="208" mass="24300" checksum="6F11D874FFA60C5F" modified="2019-05-08" version="1" fragment="single">MVQTNEISKIQEKNRLLEGKVSDIEARHRTELGSIRKEKELLQQLVTHQISNIRELEKRLHTASSNSSGLQLQQLQLVETVRQLINLVSQGKAMVKKEDKIFRDCADALESGANMSGVYTIHIENMTNSHKVYCQMETSGGGWTVIQRRVNGSTDFQRNWREYKMAFPERIQRNSRTPKQFSCSRNEFQHKRCRQRQLSLQVRIDVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRP9</accession>
    <name>A0A401NRP9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005361">
        <property type="protein sequence ID" value="GCB63578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRP9"/>
    <dbReference type="STRING" id="75743.A0A401NRP9"/>
    <dbReference type="OMA" id="RAAWMGR"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30994" checksum="622CE3485BBAAB0A" modified="2019-05-08" version="1">MTEAPLMCVYCVTGPGAGSDVAVIKIRAEKKGNEYIINGQKMWITNGGKADWSFLLARSNPDPKASAGKSFTGFIVDADSPGIQIRIKEMNMGQRCSDTRGIVFEGVRVPKENVLVGGGAGFKIAMGAIDKTRPPVAAGAIGLGQRALDEATKYALERKTFGKLLTDHQAVSLLLVEMALKVELARLSYQRAACEVDQGLRNTYYTSIAKTFAGDIVNQVAGDAVQIFRGNGFNSEYPVEKLMGDAKIYQIYKGTAQIQRLIIALEHIGKYKQVKEPCVQSPTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTQ7</accession>
    <name>A0A401NTQ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted phosphoprotein 24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Secreted phosphoprotein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Could coordinate an aspect of bone turnover.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005435">
        <property type="protein sequence ID" value="GCB64256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTQ7"/>
    <dbReference type="STRING" id="75743.A0A401NTQ7"/>
    <dbReference type="OrthoDB" id="9944258at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046849">
        <property type="term" value="P:bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010892">
        <property type="entry name" value="Spp-24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15444">
        <property type="entry name" value="SECRETED PHOSPHOPROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15444:SF4">
        <property type="entry name" value="SECRETED PHOSPHOPROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07448">
        <property type="entry name" value="Spp-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019228244" description="Secreted phosphoprotein 24" evidence="11">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB64256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="21554" checksum="B11D329382F88EB4" modified="2019-05-08" version="1">MKSLLLTIAAVQILHCSGMPSPKDALRASVLKLNKITEITNLCGITRRRVKDVYRTGKLSYNVDLTFSVKETVCSKNSGLEFDDPSCHFRSKKSAEKGLCKSRVEYFAGEVIEVDVECRGMKTFDSNSKSSESSENSLEVQTKSMETSIEELPNVESKSAESSLEESPNVRSKSAETSFDVSSNEHNDDSRDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU35</accession>
    <name>A0A401NU35_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphofurin acidic cluster sorting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0007526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002746">
        <property type="protein sequence ID" value="GCB64367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU35"/>
    <dbReference type="STRING" id="75743.A0A401NU35"/>
    <dbReference type="OMA" id="CTSTHAD"/>
    <dbReference type="OrthoDB" id="28829at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF15">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25332">
        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="5">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="4">
        <location>
            <begin position="451"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB64367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="68032" checksum="B5CE4CA42967F85B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVS7</accession>
    <name>A0A401NVS7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005516">
        <property type="protein sequence ID" value="GCB64981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVS7"/>
    <dbReference type="STRING" id="75743.A0A401NVS7"/>
    <dbReference type="OMA" id="WHNYESI"/>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000107">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF129">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="154" mass="17997" checksum="E74B2CF6B7CAA316" modified="2019-05-08" version="1">MRSYSKMNKRFPFGPNEDRSYGWTDGLKRKDWHNYEIIQQDLMRSGKGEHGKPYPLAEEDQSDSAYRENGFNIYVSNSIALDRSLPDIRHPNCKHKMYLEKLPNTSIIIPFHNEGWSSLLRTVHSVVSRSPDQLVAEIILVDDFSDRGKQERQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW94</accession>
    <name>A0A401NW94_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0004724</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001418">
        <property type="protein sequence ID" value="GCB65153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW94"/>
    <dbReference type="STRING" id="75743.A0A401NW94"/>
    <dbReference type="OMA" id="VESCAVH"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000900">
        <property type="entry name" value="Zinc finger and BTB domain containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000312">
        <property type="entry name" value="Zinc finger and BTB domain-containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000550">
        <property type="entry name" value="Zinc finger and BTB domain-containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000166">
        <property type="entry name" value="Zinc finger and BTB domain-containing 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001300">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001378">
        <property type="entry name" value="Zinc finger protein 652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000284">
        <property type="entry name" value="Zinc finger protein 652 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB65153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="674" mass="77794" checksum="B0CFDE004D1DEFC7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXS5</accession>
    <name>A0A401NXS5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anterior gradient protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0011899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005586">
        <property type="protein sequence ID" value="GCB65666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXS5"/>
    <dbReference type="STRING" id="75743.A0A401NXS5"/>
    <dbReference type="OrthoDB" id="262308at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02960">
        <property type="entry name" value="AGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000036">
        <property type="entry name" value="anterior gradient protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF5">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB65666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24961" checksum="1EA3337556AF2B27" modified="2019-05-08" version="1">MKWNFAAGGISAGAFINKSGADDDVADVAVKTESSEETKLYRREKKSFSKNSIITAIMLRLFVPVFLLLVAATSSQATTIKKRPPQTLSRGWGDDLTWVQTYEEGLYKAKKSNKPLMIIHHLQDCKYCQALKDVFAGNEEIQTMADKDFIMLNLMHETVDKNLAPDGKYVPRIMFVDPSLTVRADIVGKYSNRLYTYEPQDIQLLIQNMKRSKRLMPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZA2</accession>
    <name>A0A401NZA2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho GTPase-activating protein 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rho-type GTPase-activating protein 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0014962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008258">
        <property type="protein sequence ID" value="GCB66180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZA2"/>
    <dbReference type="STRING" id="75743.A0A401NZA2"/>
    <dbReference type="OMA" id="IDDQHCK"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13319">
        <property type="entry name" value="PH_RARhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17115">
        <property type="entry name" value="RA_RHG20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04402">
        <property type="entry name" value="RhoGAP_ARHGAP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000217">
        <property type="entry name" value="Rho GTPase activating protein 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000025">
        <property type="entry name" value="Rho GTPase-activating protein 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047886">
        <property type="entry name" value="ARHGAP20-like_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047887">
        <property type="entry name" value="ARHGAP20_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047888">
        <property type="entry name" value="ARHGAP20_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF28">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22286">
        <property type="entry name" value="RHG20_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="133"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="304"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="896"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00055252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB66180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1117" mass="124065" checksum="3EAE9B0C0C388475" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0K8</accession>
    <name>A0A401P0K8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005689">
        <property type="protein sequence ID" value="GCB66643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0K8"/>
    <dbReference type="STRING" id="75743.A0A401P0K8"/>
    <dbReference type="OMA" id="NANPHEG"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22088">
        <property type="entry name" value="F-box_FBXO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048003">
        <property type="entry name" value="FBXO8_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF372">
        <property type="entry name" value="F-BOX ONLY PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="145"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39106" checksum="06F0D3E37BC6CEA0" modified="2019-05-08" version="1" fragment="single">VVEIGRNCGSNRVDIFIKNKLTKMGQGLWRVVRNQQLQHRRYSEEGYYLGEHDRRLAAASRRHAQVGIDIYHVLRVGRSKEEHGFPDLELLPPELSLTILSYLNATDLCLASCVWQDLANDDVLWQGLCKSTWGHCSIYYRDHPSNFNYRKLYMQLDEGSLTFNANPHEGIGYVFRKGILDNVPKEIAKFIFYTRTLNWKKLRIYLDDRRDVLDELVTLHNFSNQFLPNALREFFRHIHAPEERGEYLETLITKFSQRFCACNPAVTRDLGLSPDAVYVLCYSLILLSIDLNSPHVKNKMSKREFIRNTRRAAHNISEDFVGHLYDNIYLVGHVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0N3</accession>
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        </alternativeName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004307">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="P:neuron projection development"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 9 LIKE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
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    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
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        </location>
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    </feature>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50105"/>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1328" mass="149277" checksum="DC35197F72D4A218" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0R5</accession>
    <name>A0A401P0R5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAUS augmin-like complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
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        <lineage>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
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                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43234" checksum="C8680F2C09F37D06" modified="2019-05-08" version="1">MDGEDAFFQGPERRRLSRWPFVMAAGLSEAQLGTRVMQKLLNLKCPFLEGIRVNDSDAAIRLLCTPGVDRLQILEWLCISCYPPLERKFAELHFHSMQDHGTDLAIKEMAWLGYMLGVCNIEDFDLFLGQASPHRQLVMMDEMLSGLQQYEQITEATSTDLKGISSVHAWNSQLLIEVQNDPHLRSPANLEFNLSLDAHRLLKRAEANFESRGRKKFSPPSIDSMEKLLIKLSEELKETNQHLEEMKKTVAFLGPIESSDTTFQTLKLTLSDFHQLMTVFSLTFEHEFGAHCNKAPPQLCNFGSLCKTVHKLLTSCIDELAALAEISDTCRKLETIVNGLQQDVINWQGGEVATLPVRVTEMKKKYAEFLEVFRSPCIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0U2</accession>
    <name>A0A401P0U2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005699">
        <property type="protein sequence ID" value="GCB66731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0U2"/>
    <dbReference type="STRING" id="75743.A0A401P0U2"/>
    <dbReference type="OrthoDB" id="10055441at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF3">
        <property type="entry name" value="NUCLEAR FACTOR 1 X-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00859">
        <property type="entry name" value="CTF_NFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16908" checksum="7D7E276181C64768" modified="2019-05-08" version="1">MEEDIGWRRGTNDQRWIAHPTLKFIDGRKLAKIKRDQGKNIEQRPEGDEEYRRLDKADEEGLRRDPAEEFKTMRRFEEPNRGHLNFQDCFITSGVFSVSELVRVSQTPVAAATGPSFNLADLESPGYYSINQVPLGRRTITTPPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0W1</accession>
    <name>A0A401P0W1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0007929</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002963">
        <property type="protein sequence ID" value="GCB66743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0W1"/>
    <dbReference type="STRING" id="75743.A0A401P0W1"/>
    <dbReference type="OMA" id="CHANLET"/>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000001">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000004">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000003">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044912">
        <property type="entry name" value="Egfr_JX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF90">
        <property type="entry name" value="RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="500"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB66743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="597" mass="66864" checksum="F526548B71B729DF" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P105</accession>
    <name>A0A401P105_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thrombospondin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007038">
        <property type="protein sequence ID" value="GCB66783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P105"/>
    <dbReference type="STRING" id="75743.A0A401P105"/>
    <dbReference type="OrthoDB" id="6380629at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="4">
        <location>
            <begin position="324"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB66783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="742" mass="80185" checksum="F1830AF3422BD479" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P215</accession>
    <name>A0A401P215_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0013661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007078">
        <property type="protein sequence ID" value="GCB67140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P215"/>
    <dbReference type="STRING" id="75743.A0A401P215"/>
    <dbReference type="OMA" id="RFKMLAP"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB67140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="189" mass="21494" checksum="58ED2F8738EDAEE1" modified="2019-05-08" version="1">MGGSASHLSKEQLSEYQELTFLTKQDILHAYRIFTELLSKDLVDFQNIRIAKERFCELPELKANPFRERICLVFSTAIEKDGSVSFEDFLDMLSAFSDSATLEIKSHYAFRIFDFDDDGTLDKEDLKNLVNCLTGGTSDTQLSEAEMNQLIQNILEEADIDKDGTVNLSEFQHVISRSPDFVSSFKIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2N2</accession>
    <name>A0A401P2N2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000146">
        <property type="protein sequence ID" value="GCB67394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2N2"/>
    <dbReference type="STRING" id="75743.A0A401P2N2"/>
    <dbReference type="OrthoDB" id="10034042at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF9">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="159" mass="18242" checksum="81919F78B5EADBAF" modified="2019-05-08" version="1">MVFQEITDVNQRNKCLDMKGEKLDYESCEALEEIFRRMQFKLINLEWVKLDEDGASALFDIMEYYDSAVHLSISFTKHIGTRGWIAAAQLIRKSSSLQEFEACGIPLMENSACFVARGLRFNSHLRVLRLDNASMSGRPLMLLGKQEWGTVKQILTTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2Q1</accession>
    <name>A0A401P2Q1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ceruloplasmin</fullName>
            <ecNumber evidence="13">1.11.1.27</ecNumber>
            <ecNumber evidence="4">1.11.1.9</ecNumber>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
            <ecNumber evidence="15">1.16.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Cuproxidase ceruloplasmin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Ferroxidase ceruloplasmin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Glutathione peroxidase ceruloplasmin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Glutathione-dependent peroxiredoxin ceruloplasmin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">scyTo_0005123</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16834"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="EC" id="1.16.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:30084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:11150"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:78539"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:78540"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:62633"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Found in a complex with MPO and LTF; interacts directly with MPO and LTF, which allows Fe(3+) incorporation into LTF, activation of CP ferroxidase activity and protection of CP antioxidant properties by MPO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.27" evidence="13"/>
    <dbReference type="EC" id="1.11.1.9" evidence="4"/>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EC" id="1.16.3.4" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01001569">
        <property type="protein sequence ID" value="GCB67414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2Q1"/>
    <dbReference type="STRING" id="75743.A0A401P2Q1"/>
    <dbReference type="OMA" id="TTDHYAG"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04222">
        <property type="entry name" value="CuRO_1_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11022">
        <property type="entry name" value="CuRO_4_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000009">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000015">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000028">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000033">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000037">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF226">
        <property type="entry name" value="CERULOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 27" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019335088" description="Ceruloplasmin" evidence="27">
        <location>
            <begin position="20"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="29">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="28">
        <location>
            <begin position="315"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="29">
        <location>
            <begin position="452"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="28">
        <location>
            <begin position="960"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00072777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00078105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00080685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00082571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="GCB67414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123588" checksum="79572C2FDBD1E1A0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3L4</accession>
    <name>A0A401P3L4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001591">
        <property type="protein sequence ID" value="GCB67745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3L4"/>
    <dbReference type="STRING" id="75743.A0A401P3L4"/>
    <dbReference type="OMA" id="TIDANDC"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB67745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="413" mass="46101" checksum="3A1A4552F1B8CED9" modified="2019-05-08" version="1" fragment="single">RGPPHRPAEQPVPGTTSPPSRAARPGNHLSPSGPGKRTASLSYPGTSGWRISELITRGPRGNWFNMEHVTSAARAEIKQRGVCFANTDATPAVVKTGKRQTPFRQSSAIRKIPRTDLPVENAEQIAALLQKQWRLYHLTPLYRFSYTMLKKYSNELSVFIATEQKRGVAIEVGIELASKAKFSMLAGLRATENDPEAVSIQITTKTSVHQAVAEKVVWSGWMCCVDGDLGFLESLPVEFICLPLLFANGPETVTTMVGEWLQKTFDCYISAFPISSENLTWMAAMWANCFSDSVHRVMELEWSVPPVQLTISLSIHPEDAKALWDSIHEDEDEITIDEVELFMSCLHSHFYRHFGVRLAATQLVKVSTAVASAHCDGKLKLFNSKHIDHVLPFLTELAFHQIQYQPRLCNSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4G9</accession>
    <name>A0A401P4G9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acidic leucine-rich nuclear phosphoprotein 32 family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0005239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Multifunctional protein that is involved in the regulation of many processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ANP32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001609">
        <property type="protein sequence ID" value="GCB67986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4G9"/>
    <dbReference type="STRING" id="75743.A0A401P4G9"/>
    <dbReference type="OMA" id="MPNNQVS"/>
    <dbReference type="OrthoDB" id="2160613at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000003">
        <property type="entry name" value="Acidic leucine-rich nuclear phosphoprotein 32 family member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF2">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB67986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="255" mass="29395" checksum="D3F1158B69FE488B" modified="2019-05-08" version="1">MKRRIHLELRNRTPSDVRELVLDNCRSNEGKIEGLTAEFENLEFLSLINVGLMSVTNLLRLPKLKKLELSDNRISGGLDVLAEKLPNLTHLNLSGNKLKDISTLEPLKKLENLKSLDLFNCEVTNLNDYRESVFKLLPQLMYLDGYDQEDREAPDSDAEVDGVDDDEDDEEGEEEEEEDEEEDGEEELDEEDDDEEGEDDEDEVSAEEEEGYEHDGEIDEEDDDEEEDDDEEEEESTKGEKRKRDTEDEGEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5T4</accession>
    <name>A0A401P5T4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger HIT domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0008231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with NUFIP1. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003108">
        <property type="protein sequence ID" value="GCB68463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5T4"/>
    <dbReference type="STRING" id="75743.A0A401P5T4"/>
    <dbReference type="OMA" id="PCASAKS"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048371">
        <property type="entry name" value="ZNHIT3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21373">
        <property type="entry name" value="ZNHIT3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB68463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="18465" checksum="840173659FAEDBB0" modified="2019-05-08" version="1">MCEEQPPKYRCPRCELRYCSVGCYKIHKDACKPQESGSVSTISELYPALKEVIQQDGNGHHFPDIFDDEENGDEEEESDRVPLEKLRLLAESKELKSLLCNPHLKQLLLTVDRAEDKESIMKTAMQEPIFVEFADQCLQIVEPPEKENEIFASEYKLFNP</sequence>
</entry>
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        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039473">
        <property type="entry name" value="TMEM2_PANDER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535:SF26">
        <property type="entry name" value="CELL SURFACE HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10162">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01225">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="G8" evidence="11">
        <location>
            <begin position="123"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB68682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="801" mass="88337" checksum="09563851B3B1C682" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6Y8</accession>
    <name>A0A401P6Y8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IGFBP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004519">
        <property type="protein sequence ID" value="GCB68863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6Y8"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019025152" description="IGFBP N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8750" checksum="0A65D378D658443C" modified="2019-05-08" version="1">MLRLLLLFLCLVRHPVSCANCPQLCSCERGDHITCEGREVDHIPKELSPGCCKLICVYLHPRQCSLRSRRTPCNQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7B7</accession>
    <name>A0A401P7B7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB/POZ domain-containing protein KCTD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0005404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with HCN3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KCTD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001675">
        <property type="protein sequence ID" value="GCB69015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7B7"/>
    <dbReference type="STRING" id="75743.A0A401P7B7"/>
    <dbReference type="OMA" id="SPGTEMK"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18393">
        <property type="entry name" value="BTB_POZ_SHKBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000205">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000038">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047876">
        <property type="entry name" value="SHKBP1/KCTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047825">
        <property type="entry name" value="SHKBP1_KCTD3_BTB_POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="747"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB69015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="823" mass="89658" checksum="4CF834E98A7E1F25" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7Y0</accession>
    <name>A0A401P7Y0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0008348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003173">
        <property type="protein sequence ID" value="GCB69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7Y0"/>
    <dbReference type="STRING" id="75743.A0A401P7Y0"/>
    <dbReference type="OMA" id="AKGQASH"/>
    <dbReference type="OrthoDB" id="10412668at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="125" mass="13600" checksum="BDE5A36D25198477" modified="2019-05-08" version="1">MGMPELAKGQASHGASKQFLSHQEAAQEAEESLQAELPHLCVPGADPGPHFHPGLLQGHELMNSFVTDIFERIASEASHLIYYNKQHIISTQEIQSAARLILSGELAKHAVSEDTKAVTKYTNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8H6</accession>
    <name>A0A401P8H6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with PTBP2; the interaction is direct.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004575">
        <property type="protein sequence ID" value="GCB69393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8H6"/>
    <dbReference type="STRING" id="75743.A0A401P8H6"/>
    <dbReference type="OMA" id="KYANTPF"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22436">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09031">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000019">
        <property type="entry name" value="RNA-binding protein Nova-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000022">
        <property type="entry name" value="RNA-binding protein Nova-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047276">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047274">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="293"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB69393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="380" mass="38361" checksum="921EC664920A8916" modified="2019-05-08" version="1">MFYDLCTEDKIKVKCEKLVLETLPSSPTTTKSSPSDPMTTTRANQVKIIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPDGINLQERVVTVSGEPEQNRKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGSPYANTAEVLPTAAAAAGLLGHANLAGVTAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAAANLLATYANEASGGGSPVGGTVGTFALGSLAAATAATNGYFGAASPLAASAILGSEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVRAANPQKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P937</accession>
    <name>A0A401P937_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Growth arrest and DNA damage-inducible protein GADD45 gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0001084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GADD45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000231">
        <property type="protein sequence ID" value="GCB69600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P937"/>
    <dbReference type="STRING" id="75743.A0A401P937"/>
    <dbReference type="OMA" id="SRSAYDW"/>
    <dbReference type="OrthoDB" id="5976967at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000018">
        <property type="entry name" value="growth arrest and DNA damage-inducible protein GADD45 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024824">
        <property type="entry name" value="GADD45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411:SF4">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="8">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB69600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="161" mass="18115" checksum="ABF4AD0AB0B4C5C6" modified="2019-05-08" version="1">MTLEEFSGVEEKQVESTERMQVAGKALEELLSSAQRQHCLTVGVYESAKVMNVDPDSVVLCLLATDEEDEGDIALQIHFTLIQAFCCDNDINIVRLNDIQRLTEIVGSAADNEEPRDMHCILVTNPNQDSWKDPALEKLGVFCEESRCTNQWVPNISFPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAU8</accession>
    <name>A0A401PAU8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trs120/TRAPPC9 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006105">
        <property type="protein sequence ID" value="GCB70242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAU8"/>
    <dbReference type="STRING" id="75743.A0A401PAU8"/>
    <dbReference type="OMA" id="ISHAEIQ"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="2">
        <location>
            <begin position="184"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="374" mass="42566" checksum="8F9E0B03EA52A330" modified="2019-05-08" version="1">MSVPDYMQCAEDHQSLLVIVQPVGIVPEEQFFKIYKKIAVANQINLRDSQRVLYIRYRHHYPPENNEWGDFQTHRKVVGLIAITQCCNAKDWPQTSEKFHLQKEIYGSTLYDSRLFVFGLQGEIAEQPRTDVAFYSSYDECETIEKKVEDFIESLFIVLESKRLDRATDKSGDKIQLLCVPFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDALVHYHMAVELLRSVNDFLWLGAALEGLCSSSVIYHYPSGTGSKPSIRRDSNVCLPSEAGKRHRHGALTTNGISADTSTEIGRAKNCLSPEDIIDKYKEAITYFGKYKNAGVIELEACVKAVKVLAIQKRSMEASEFLQNAVYINLGQVVFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBT2</accession>
    <name>A0A401PBT2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0005712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001823">
        <property type="protein sequence ID" value="GCB70574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBT2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="85" mass="9308" checksum="672F3AFB2DE95911" modified="2019-05-08" version="1">MHSSSTLCYHTEDLTIGKFPGLLVYDSYSERCLLAALGGIQINELTLPHHISGFIGVRKAVNSRQTTCVSQIEMEGLGMYSDSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCG0</accession>
    <name>A0A401PCG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001852">
        <property type="protein sequence ID" value="GCB70812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCG0"/>
    <dbReference type="STRING" id="75743.A0A401PCG0"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF65">
        <property type="entry name" value="SEMAPHORIN-6D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019241776" description="Sema domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="8">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB70812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="702" mass="77783" checksum="A930E3A6BC132DDF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDN1</accession>
    <name>A0A401PDN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stereocilin LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0008786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mesothelin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003428">
        <property type="protein sequence ID" value="GCB71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDN1"/>
    <dbReference type="STRING" id="75743.A0A401PDN1"/>
    <dbReference type="OMA" id="TCEMIDN"/>
    <dbReference type="OrthoDB" id="8195838at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010335">
        <property type="entry name" value="Mesothelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026664">
        <property type="entry name" value="Stereocilin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048992">
        <property type="entry name" value="Stereocilin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412:SF18">
        <property type="entry name" value="OTOANCORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412">
        <property type="entry name" value="STEREOCILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06060">
        <property type="entry name" value="Mesothelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21058">
        <property type="entry name" value="Stereocilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Stereocilin LRR" evidence="8">
        <location>
            <begin position="248"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119494" checksum="EFFC57A96AE752E3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDR7</accession>
    <name>A0A401PDR7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0010964</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004843">
        <property type="protein sequence ID" value="GCB71249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDR7"/>
    <dbReference type="STRING" id="75743.A0A401PDR7"/>
    <dbReference type="OMA" id="DNNVIRW"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005334">
        <property type="term" value="F:norepinephrine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB71249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="112" mass="12762" checksum="07727D5D8223C490" modified="2019-05-08" version="1">MFVKHLQITRRGVLHLHESAGIHNLGLPRWQLSLCLLVVVIIIYFSLWKGVKTSGKVVWITATMPYMVLLVLLIHGITLPGAMNGIRAYLSIDFERLKEAQVDCSPFLHWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE48</accession>
    <name>A0A401PE48_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MORN repeat-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001925">
        <property type="protein sequence ID" value="GCB71388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE48"/>
    <dbReference type="STRING" id="75743.A0A401PE48"/>
    <dbReference type="OMA" id="WEDSIIH"/>
    <dbReference type="OrthoDB" id="437960at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052849">
        <property type="entry name" value="MORN_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7704" checksum="2F2DF4926D7BF22A" modified="2019-05-08" version="1" fragment="single">AIYEGEFKDNKFHGTGIYTWPNKLTYIGSFNENKLEGEGKFIDADDYEWVGTFHDRAAPGLKLKLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEJ9</accession>
    <name>A0A401PEJ9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Prolyl 4-hydroxylase subunit alpha-1</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0005969</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01001945">
        <property type="protein sequence ID" value="GCB71525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEJ9"/>
    <dbReference type="STRING" id="75743.A0A401PEJ9"/>
    <dbReference type="OMA" id="YLPHFDF"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF101">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="18">
        <location>
            <begin position="450"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB71525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="573" mass="65544" checksum="D96BDF7F0C3038C5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEU6</accession>
    <name>A0A401PEU6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L27-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003513">
        <property type="protein sequence ID" value="GCB71680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEU6"/>
    <dbReference type="STRING" id="75743.A0A401PEU6"/>
    <dbReference type="OMA" id="SPIHTSC"/>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L27-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="19076" checksum="1145947C2E1F574B" modified="2019-05-08" version="1">MVHREDTERAVQLLATYCRNLPELEEEKLRVTIGKVTNIFKSDLFRALLDIQEFYEVTLVAALKLTDQNLVASNLFSAEVGRTSEFTSIELLSPERYDHCDKGIISSYLPNQSAIEDMPELIQIKEKTTFEVENACSYVSPIHTSCPEVSVIFSFICGIVKNEKDIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFI9</accession>
    <name>A0A401PFI9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0001741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000403">
        <property type="protein sequence ID" value="GCB71902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFI9"/>
    <dbReference type="STRING" id="75743.A0A401PFI9"/>
    <dbReference type="OMA" id="KFTMKMI"/>
    <dbReference type="OrthoDB" id="10061535at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000076">
        <property type="entry name" value="Leucine-rich repeat and Ig domain-containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000014">
        <property type="entry name" value="Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF207">
        <property type="entry name" value="LEUCINE RICH REPEAT AND IG DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019300522" description="Ig-like domain-containing protein" evidence="12">
        <location>
            <begin position="24"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="406"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB71902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="602" mass="67260" checksum="335E8D6EDDAE3E7B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFN2</accession>
    <name>A0A401PFN2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0008976</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003551">
        <property type="protein sequence ID" value="GCB71931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PFN2"/>
    <dbReference type="OMA" id="CADISEK"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000068">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR GLI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="422"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="638"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="645"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB71931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1393" mass="152856" checksum="67FED380D74D90BD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG53</accession>
    <name>A0A401PG53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0009030</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPII-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003586">
        <property type="protein sequence ID" value="GCB72112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG53"/>
    <dbReference type="STRING" id="75743.A0A401PG53"/>
    <dbReference type="OMA" id="LFHGERE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000011">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF10">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="15">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="16">
        <location>
            <begin position="213"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="18">
        <location>
            <begin position="489"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="17">
        <location>
            <begin position="606"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="720"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB72112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="853" mass="95913" checksum="4FB337BA11C82E9B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG91</accession>
    <name>A0A401PG91_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartoacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0001838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000428">
        <property type="protein sequence ID" value="GCB72135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG91"/>
    <dbReference type="STRING" id="75743.A0A401PG91"/>
    <dbReference type="OMA" id="CEVIPYL"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050178">
        <property type="entry name" value="AspA/AstE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055438">
        <property type="entry name" value="AstE_AspA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA_hybrid_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002601">
        <property type="entry name" value="PRK02259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15162">
        <property type="entry name" value="ASPARTOACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15162:SF9">
        <property type="entry name" value="ASPARTOACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24827">
        <property type="entry name" value="AstE_AspA_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA_hybrid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Succinylglutamate desuccinylase/Aspartoacylase catalytic" evidence="6">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="AstE/AspA barrel-sandwich hybrid" evidence="5">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB72135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26350" checksum="9E8982CF97F7075D" modified="2019-05-08" version="1">MPPNDSLPYEVKRAQEINRLFGPKDSENAYDLAIDLHNTTSNMGNCLIMKTSKDDFTIQMINYIKNTLTHDNCQVLLLENPAVQYGAIRTVAKHSVGLEIGPQPQGVVRANILANMRKLVNSALDFTHFYNEGKEFPPCTLDVYRAFEKVDYPRDSEGQIIAIIHPQLQDNDWKQLKPGDPSFLTLDGKTIPYNGSSAVYPVFVNEAAYYEKESAFLLTQKVTLKANSMKVCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHA9</accession>
    <name>A0A401PHA9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger and BTB domain-containing protein 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Zinc finger protein 288</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0002042</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Can homodimerize. Binds to DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB72523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHA9"/>
    <dbReference type="STRING" id="75743.A0A401PHA9"/>
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    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_ZBTB20_DPZF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger and BTB domain containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000304">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000315">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000426">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 17" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="60"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="539"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="567"/>
            <end position="594"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="623"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="655"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="306"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="159"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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            <end position="390"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00053801"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079204"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB72523.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="681" mass="75991" checksum="1AFF290451A1F34F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI61</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="synonym">Catulus torazame</name>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21590:SF3">
        <property type="entry name" value="UPF0606 PROTEIN KIAA1549L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12877">
        <property type="entry name" value="KIAA1549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="EMBL" id="GCB72816.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="8">EF-hand calcium-binding domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002184">
        <property type="protein sequence ID" value="GCB72779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI65"/>
    <dbReference type="STRING" id="75743.A0A401PI65"/>
    <dbReference type="OMA" id="KTIDKYW"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903569">
        <property type="term" value="P:positive regulation of protein localization to ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000193">
        <property type="entry name" value="EF-hand calcium-binding domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB72779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="620" mass="70043" checksum="60B021A234B99FCF" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJX6</accession>
    <name>A0A401PJX6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0006767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002339">
        <property type="protein sequence ID" value="GCB73430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJX6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019453860" evidence="2">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="7305" checksum="40467D6136AFC1E0" modified="2019-05-08" version="1">MNKMLICLLACCLMLSVSTAQKGITKPPASSTQGKINPTTPKNGAAGFVSATATLLVLPFLPVFLQRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLZ6</accession>
    <name>A0A401PLZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000864">
        <property type="protein sequence ID" value="GCB74133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLZ6"/>
    <dbReference type="OMA" id="VRDENEQ"/>
    <dbReference type="OrthoDB" id="10053382at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038827">
        <property type="entry name" value="CCDC152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35253">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35253:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="20153" checksum="349EAD1A263C370F" modified="2019-05-08" version="1" fragment="single">KIAETQGKNNLLEIQLEEANRLVKLTQTKENCMKEECGLLHGIITELQGSIQKQCDVRVETKQEELDGIIDKKETEIQLLNRQIHSQEREKQSEIIKLQMEFNTKLLKIQSTSKKSPHQDSSALPQNIFKRKLQHLQEEKNREMAGLRRTIRELEQQRDCTPDSHLKRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN09</accession>
    <name>A0A401PN09_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0003625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001006">
        <property type="protein sequence ID" value="GCB74534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN09"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028745">
        <property type="entry name" value="AKAP9/Pericentrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB74534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="11997" checksum="228011A8B6C8A62B" modified="2019-05-08" version="1">MQLTWELHPAGGISDGYTEGKACLERQVRKKAEIQHQISQELLQTSNRLHEIEEEQQKPQEGREQPTRNKLQELWSSKNSQIPIIMVTQEMVALGSGQEEQMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNG7</accession>
    <name>A0A401PNG7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001055">
        <property type="protein sequence ID" value="GCB74667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNG7"/>
    <dbReference type="STRING" id="75743.A0A401PNG7"/>
    <dbReference type="OMA" id="CVRYRDF"/>
    <dbReference type="OrthoDB" id="272072at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF0">
        <property type="entry name" value="GH12158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="718" mass="83371" checksum="539383183EF98139" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNM4</accession>
    <name>A0A401PNM4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0003800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001067">
        <property type="protein sequence ID" value="GCB74709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNM4"/>
    <dbReference type="STRING" id="75743.A0A401PNM4"/>
    <dbReference type="OMA" id="HIEQFIT"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB74709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="101" mass="11848" checksum="D33704D3385B1C15" modified="2019-05-08" version="1">MVFTVRHATVTFQTDGDTWREQKEKKAALMVGILIGVFVLCWIPFFITELINPLCSCDIPPVWKSVFLWLGYSNSFFNPLIYTAFNKNYNNAFRNLFSRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP71</accession>
    <name>A0A401PP71_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0019689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014899">
        <property type="protein sequence ID" value="GCB74927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP71"/>
    <dbReference type="STRING" id="75743.A0A401PP71"/>
    <dbReference type="OMA" id="RTIGMDC"/>
    <dbReference type="OrthoDB" id="5948587at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000006">
        <property type="entry name" value="growth/differentiation factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF166">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="10">
        <location>
            <begin position="138"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB74927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="250" mass="28742" checksum="D878F0B6BAF046C4" modified="2019-05-08" version="1" fragment="single">EPCVQVDGSPKCCFFKFSPKITFTNVVRAHLWVYLRPVLHTSTVYLQILRLKPVTEKGSRHSRIRSLKIDLNSRNGRWQSIDFKHVLQNWFKQPHTNWGIEINAFDMNGNDLAITSPGNGEKGLQPFLEVKVAETNKRTRRNLGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVHHANVQGSAGPCCTPTKMSPINMLYFNDKQQIINGQIPGMVVDRCGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPK2</accession>
    <name>A0A401PPK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013667">
        <property type="protein sequence ID" value="GCB75076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPK2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="42" mass="5101" checksum="3FF3CABEA0FFBE2A" modified="2019-05-08" version="1" fragment="single">HNKGETTWQDQTHANCLKDGNRNHVVENRQKYVEWTTVRYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQN4</accession>
    <name>A0A401PQN4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008641">
        <property type="protein sequence ID" value="GCB75430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQN4"/>
    <dbReference type="STRING" id="75743.A0A401PQN4"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000003">
        <property type="entry name" value="Deleted in malignant brain tumors 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF27">
        <property type="entry name" value="SCAVENGER RECEPTOR CYSTEINE-RICH TYPE 1 PROTEIN M130-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="207"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="232"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="245"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB75430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42268" checksum="24D964354646AA19" modified="2019-05-08" version="1" fragment="single">KLQSPNIRQIRPSGQYLEGQIAEITCSAPKVYSGITYNLFKVGSITAVASLGPTSNSTALLTIRDIRSTSEGSYTCSYQAPVWGRTYHSAPSASVNITLAHRPEGPTLTMTTLFGLYLQGKSIRITCMAPEYYTTNSFYLLRNGKDTIMPWISTQWTQHGAEFRIANTSTSDSGNYSCIYETQINGKAFNSTDSNFVSIEVQERVAIRLVNGSSICSGRVEILNNKTWGTVCDDQWQLPDAQVVCRELRCGAAVSALTHAYFGKGTGPIALDDLECRGTEVYLWQCPSRHWGQHNCLHEEDAGVICSDTLMNRRSAPPASSKRKGIIGFCVAGLIFAVIAVFVANHYRKSGYVWNRKGSRIQNLQPLITNQEEPDRSDEDSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQS0</accession>
    <name>A0A401PQS0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01008648">
        <property type="protein sequence ID" value="GCB75474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQS0"/>
    <dbReference type="STRING" id="75743.A0A401PQS0"/>
    <dbReference type="OrthoDB" id="10051650at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF285">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="218"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB75474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="322" mass="36541" checksum="8C4DB665FD18FC7F" modified="2019-05-08" version="1">MWVAALEGNPEPCNQLLSGGMNATTDVHNNFSNNADYWRLALRLCAARQPYNQQKNRYGDVLCLDQTRVKLKSLNHDERTDYINASFMDGYKQKNAYIGTQGVNIQIILFCPEAEHRTKKTRSTKASSNAVYQVPAERGLIDESGRKKCGQYWPLDQNIQGNYGLTSVKNLAVESFKHYNKTTLEILNVESYERRQVIHFQYLSWPDYGVPSSATALIDFRSAVRQQQGLSVQSLGNRWKGHPGGPPIVVHCSAGIGRTGTLCTLDICLSQLEHVGTLNIYQTVRRMRTQRAFSIQTPDQYYFCYTAIIEHAQRQNLLSVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQY9</accession>
    <name>A0A401PQY9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015078">
        <property type="protein sequence ID" value="GCB75531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQY9"/>
    <dbReference type="STRING" id="75743.A0A401PQY9"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="980" mass="106631" checksum="C381DFB9EEA9EC85" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRY2</accession>
    <name>A0A401PRY2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0015384</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008711">
        <property type="protein sequence ID" value="GCB75875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRY2"/>
    <dbReference type="STRING" id="75743.A0A401PRY2"/>
    <dbReference type="OMA" id="ANITLLX"/>
    <dbReference type="OrthoDB" id="5917255at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05763">
        <property type="entry name" value="IgI_LRIG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000161">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000040">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000150">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000224">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000023">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF16">
        <property type="entry name" value="LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019361662" description="Ig-like domain-containing protein" evidence="14">
        <location>
            <begin position="28"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="791"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="486"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="590"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="684"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1031"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1056"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB75875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121668" checksum="0F56A391998C5153" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS76</accession>
    <name>A0A401PS76_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012578">
        <property type="protein sequence ID" value="GCB75953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS76"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="14433" checksum="EAAC9ED9774ADA2A" modified="2019-05-08" version="1" fragment="single">GVGGGAGAEAGCPERNDVRRFSWCSSVPGVASGISGEAESLFLQVRLRRSQRMKACQSVWMNSVRNTERFWAQEKDESIADNQCIRSELYFIQGTKLKKMSILVEFTKTMTTKAQRKHIGRQSLSAQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTZ3</accession>
    <name>A0A401PTZ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008824">
        <property type="protein sequence ID" value="GCB76543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTZ3"/>
    <dbReference type="STRING" id="75743.A0A401PTZ3"/>
    <dbReference type="OrthoDB" id="10034090at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15738" checksum="32350746B033CD36" modified="2019-05-08" version="1">MAAIGTDKELSDLLDFSAMFSPPVNSGKNGPTTLASSQFGGSVMEERTGTTSWGSADQPRPSYESSRAFADSPHYGEHLNESRLGTHEGLSPTPFMNSSLMGEFHMTSRKQAPPVQWSCELFAVVGSGCSLSMLLLLLLLLVSSAACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUK6</accession>
    <name>A0A401PUK6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012752">
        <property type="protein sequence ID" value="GCB76782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUK6"/>
    <dbReference type="STRING" id="75743.A0A401PUK6"/>
    <dbReference type="OMA" id="QCHICFN"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16472">
        <property type="entry name" value="RING-H2_RNF38-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF15">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB76782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="452" mass="49640" checksum="64B8E38BB9733F5A" modified="2019-05-08" version="1">MTNSTATQTPEKRVKRLSVEDGKAYPSCFLLKSPVCLKPKQNKSSPSPKSKRVNAAKASTAKRFLQLPSKQSAAESKLFSKSRDSSASPVKTSCCVVTHCHSPSVTSSPYSPAMKRARSSSESLAASSSNSQSPSLSKISNAHLKENGSIDSTSTSPAFELCTGAFAITSALKSAASSSNSTLAILANGASDWIDLLDDEAVASPTPREQWKWEPSIIVVDDDDDSTDAFVRFAQLEEDEAFARQLQAQFDMEAQQQSENTRPTSATRENSFHNFCGLPGCGEYEALLASSDIGYCGMPGCSGYQHRNGMLNPAVIDPVLHGLQRLFDETNVRRRRNRRRSRHQTTSLYLDESANDGNDYEELLDFEERQGSAVAQRKLSNAEINCLPTKLFDPEHAAGKTQCHICFNDYTAREKLRILPCLHDYHSRCIDRWLKGNSSCPICRVDVNLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUK7</accession>
    <name>A0A401PUK7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014042">
        <property type="protein sequence ID" value="GCB76826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUK7"/>
    <dbReference type="STRING" id="75743.A0A401PUK7"/>
    <dbReference type="OMA" id="STHACIQ"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070016">
        <property type="term" value="F:armadillo repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000079">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF3">
        <property type="entry name" value="STRIATIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="13513" checksum="27B75336F4491A1F" modified="2019-05-08" version="1">MLTSPLANQINRVVSHPTLPVTITAHEDRHIKFFDNKTGKLIHAMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKCDESIYDVAFHPSKAYIASAGADALAKVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXM1</accession>
    <name>A0A401PXM1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0015728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009064">
        <property type="protein sequence ID" value="GCB77881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXM1"/>
    <dbReference type="STRING" id="75743.A0A401PXM1"/>
    <dbReference type="OMA" id="KVWALHC"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019525533" evidence="3">
        <location>
            <begin position="20"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB77881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="903" mass="102793" checksum="9955814E47508405" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYE0</accession>
    <name>A0A401PYE0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Parathyroid hormone/parathyroid hormone-related peptide receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">PTH/PTHrP type I receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Parathyroid hormone 1 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0020648</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016997">
        <property type="protein sequence ID" value="GCB78164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYE0"/>
    <dbReference type="STRING" id="75743.A0A401PYE0"/>
    <dbReference type="OMA" id="LICWPEG"/>
    <dbReference type="OrthoDB" id="6160250at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004991">
        <property type="term" value="F:parathyroid hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15265">
        <property type="entry name" value="7tmB1_PTHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000070">
        <property type="entry name" value="Parathyroid hormone/parathyroid hormone-related peptide receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002170">
        <property type="entry name" value="GPCR_2_parathyroid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF27">
        <property type="entry name" value="PARATHYROID HORMONE_PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00393">
        <property type="entry name" value="PTRHORMONER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB78164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="374" mass="42248" checksum="E48A6570B7E76258" modified="2019-05-08" version="1" fragment="single">RRLHCTRNYIHIHLFVSFMLRAISIFVKDAVLYSETAFLDLEGIALEDLKFITDTPLSQDKSQYIGCKVAVTIFLYFLATNYYWILVEGLYLHSLIFMTFFSDKKYLWGFTLIGWGVPAVFVAAWASVRATLADTQCWDLSAGNLKLIYQLPILAAILVNFMLFINIIRVLATKLRETNAGRCDTRQQYRKLLKSTLVLTPLFGVHYIVFMAIPYTEVSGTLWQIQMHCEMLFNSSQGCFVAVIYCFCNGEVQSEIKKAWARWTLALDFKRKARSGSTNYSYGPMVSHTNNSISTNLTPRAPQALHLNSRLGSGLLNGHRNLPGYVKNGSVSENSHPSSLPEQNGKDDEHGRSLGSAGSHKPSLVVEEERETVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZN6</accession>
    <name>A0A401PZN6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing regulator WTAP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Female-lethal(2)D homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">WT1-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Wilms tumor 1-associating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0016826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010460">
        <property type="protein sequence ID" value="GCB78503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZN6"/>
    <dbReference type="STRING" id="75743.A0A401PZN6"/>
    <dbReference type="OMA" id="GLRHAQN"/>
    <dbReference type="OrthoDB" id="3366661at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING REGULATOR WTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217">
        <property type="entry name" value="WILMS' TUMOR 1-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB78503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="375" mass="42042" checksum="2CDE5CBD29354DCB" modified="2019-05-08" version="1" fragment="single">SRWKQQEVYVHALETKCSELSSNDVSGLRESEEKLKQQQHESARRENILVMRLATKEQEMQECTNQIQYLKQVQLPSAAQLRSTLVDPAINLFFLKMKTELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTIMVLQQQLKEARQQLAQLQGQQHHQVLLSGTSRTPVPEPSAQRESIAKDCSRLVNGPTNGDASPQGRAAATFQDKTNLYRELSSTEDDFPSSPGSGNKLSNHSEERLDRAGSSNMYQLGAGYESVDSPTGSENSLTQHSNDTDSINDPQEDKPFVVKGTRTMGSRHIQNGLDSVSTQGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q005</accession>
    <name>A0A401Q005_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SERTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010498">
        <property type="protein sequence ID" value="GCB78727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q005"/>
    <dbReference type="STRING" id="75743.A0A401Q005"/>
    <dbReference type="OMA" id="SSVWEMD"/>
    <dbReference type="OrthoDB" id="6083860at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052262">
        <property type="entry name" value="E2F-SERTA_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277">
        <property type="entry name" value="CELL DIVISION CYCLE ASSOCIATED PROTEIN 4/SERTA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06031">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="1">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="320" mass="35025" checksum="75B095B5FF1A58A1" modified="2019-05-08" version="1" fragment="single">ASCRHGCDCVRARNSLSGDPALLASPPHSLYARSLMYCLMQVNMLGKGTKRKFPEEQVVDACLDSVGSNLSLPYNLQRQSLLNISLFKLQLCKMVVEPNLCRSVLIANTVRQIQEEMIQDCSWQGQAAFTGSDLYIGHTSSDSLIATDFLCTPTKELHVESSTASTSNTSTLTKSKVNCLSCENITSSSAAASAKDTSTITSDQDLVQAHFENDLNMLESEEQQVDLKQCPKPLDQVFGSFEIANYSSSLTDMTIDDLFADIDTSWHELDSVMSGLMTSPKTTPVIFELLNGLPTPINSTQNCKTDLNELDHIMEIIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q154</accession>
    <name>A0A401Q154_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013274">
        <property type="protein sequence ID" value="GCB79115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q154"/>
    <dbReference type="OMA" id="TEMTHQQ"/>
    <dbReference type="OrthoDB" id="9944956at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="223" mass="23696" checksum="5C5A0E7ED019EC49" modified="2019-05-08" version="1">MAEFGRTAGVGSAAGLNGSAPQPPPYDLNPPPYSAASPPYPSVHQRAEKHASTGYQNNYPAAMPYSPYPAYPAVPQVSYAPPQYPGYQKSPVIYVPQSTGVAALPTLPSIVYQQHPSSICVVNPQNHATTYVVNQQQLGSTYVVNQQHPSAPMVLIQPGNAARGNHIIYGNPRAMVSQQTTSLIKGLATSVLSDVEHAFNPKPGYKGKQVTIQTGGNGVIIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1A1</accession>
    <name>A0A401Q1A1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aspartate/glutamate/uridylate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0020760</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017250">
        <property type="protein sequence ID" value="GCB79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1A1"/>
    <dbReference type="STRING" id="75743.A0A401Q1A1"/>
    <dbReference type="OMA" id="ASIVEQX"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04256">
        <property type="entry name" value="AAK_P5CS_ProBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000010">
        <property type="entry name" value="Delta-1-pyrroline-5-carboxylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041744">
        <property type="entry name" value="G5K_ProBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="401" mass="43325" checksum="B982402DF24F014A" modified="2019-05-08" version="1" fragment="single">NQGREMMIVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNQLKDMTVPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLSSTLHELLRMNIVPIINTNDAVVPPPEPNSDLQGVISVKDNDSLAARLAVEMRADMLIVLSDVEGLYDSPPGLDDAKLIDTFYPGDQQSITFGTMSRVGLGGMEAKVKAALWALQGGTSVVIASGTHPKVTGHVITDIVEGKKIGTFFSERADIIHRLADLLTDNRDEILKSNKRDMEKAVALGQLSQPLLKRLSLTTAKLNSLAIGLRQIAASAQDSVGRLIRRTRVAKGLDLEQITVPIGVLLVIFESRPDCLPQVSALAIASGNGLLLKGGKEAAHSNQILHHLTQEALSLHGVKDTIHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2B3</accession>
    <name>A0A401Q2B3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013373">
        <property type="protein sequence ID" value="GCB79525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2B3"/>
    <dbReference type="STRING" id="75743.A0A401Q2B3"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="45" mass="5228" checksum="5E34206A1B4924AC" modified="2019-05-08" version="1" fragment="single">WTAFIYTLAGYVHVGPDKEKRRIEPHHVAILDDGENVQMENKVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q399</accession>
    <name>A0A401Q399_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0017976</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012120">
        <property type="protein sequence ID" value="GCB79899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q399"/>
    <dbReference type="STRING" id="75743.A0A401Q399"/>
    <dbReference type="OMA" id="DIVIRRH"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000054">
        <property type="entry name" value="Adhesion G protein-coupled receptor E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001740">
        <property type="entry name" value="GPCR_2_EMR1-like_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF433">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR E1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01128">
        <property type="entry name" value="EMR1HORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018974597" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="14">
        <location>
            <begin position="23"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="15">
        <location>
            <begin position="219"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="16">
        <location>
            <begin position="372"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB79899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="74241" checksum="0AE45395332BADDF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3S0</accession>
    <name>A0A401Q3S0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013514">
        <property type="protein sequence ID" value="GCB79990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401Q3S0"/>
    <dbReference type="OMA" id="FRIVFFR"/>
    <dbReference type="OrthoDB" id="9026019at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF13">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="137"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="367"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="492"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="601"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="833"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="950"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1283"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB79990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1423" mass="159563" checksum="9DA2F2965371DB31" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3V7</accession>
    <name>A0A401Q3V7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-3-methyladenine glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-alkyladenine DNA glycosylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-methyladenine DNA glycosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ADPG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">N-methylpurine-DNA glycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0017075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.</text>
            <dbReference type="EC" id="3.2.2.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds MBD1. Binds SSBP1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.21" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01010801">
        <property type="protein sequence ID" value="GCB80072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3V7"/>
    <dbReference type="STRING" id="75743.A0A401Q3V7"/>
    <dbReference type="OMA" id="VEAYHHT"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.300.10:FF:000001">
        <property type="entry name" value="Putative 3-methyladenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="entry name" value="Methylpurine-DNA glycosylase (MPG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429:SF0">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="305" mass="33301" checksum="EB42248CDCA720C1" modified="2019-05-08" version="1">MGPKKRKVLPARGRRRELCAELERGLGAGEEPGLGAGEEPGLGAGEELEPGLGAGEELEPGLGAGEELDPRQQQQEEGPLSSVYFNTAQVTHCRLSSSFFNRPCVTLAKEFLGQVMVRKFPDGREVKGRIVETEAYLGGEDQASHSRGGRQTPRNVAMFMSPGTMYVYQIYGVYFCLNVSSQGDGAAVLLRSLEPLQGLDAMRHFRSQRRKDTGKLLKDHELCNGPSKLCQAFDITKTFDRGDLATGTEIWMEPGPESISGADIVSTSRIGIGYAGEWVSKPLRFYIKGNKCVSVVDRKAEKVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q447</accession>
    <name>A0A401Q447_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0018030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012197">
        <property type="protein sequence ID" value="GCB80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q447"/>
    <dbReference type="STRING" id="75743.A0A401Q447"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="188" mass="20028" checksum="C71E3F08EF7FB754" modified="2019-05-08" version="1" fragment="single">PASSALLPDVVFPSSVADAISQIVRKEGVLALWSSTIPSLLLVFNPAIQFMFYEGLKRHLMRGRTELLSLEVFIIGAIAKAIATTVTYPLQTVQSILREAGFPGPVQGLGGEAAADGSYLRPDVPHLREDCRLHFPTHGSGSSCGRLTNGRATLGAPTASLGTLGDHLAVPIRTGVAALCFRRARWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4Z5</accession>
    <name>A0A401Q4Z5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009659">
        <property type="protein sequence ID" value="GCB80456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4Z5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="65" mass="7338" checksum="F3B742390A7130E3" modified="2019-05-08" version="1" fragment="single">NGQEPRVPTRQRLQLAVREKGKKQKFSEDLGRVDSRIVPKVIKITSLHKPDTASGRFVGELQNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q515</accession>
    <name>A0A401Q515_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Rab3 GDP/GTP exchange factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rab3 GDP/GTP exchange protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0017190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts (via death domain) with TNFRSF1A (via death domain). Interacts with PIDD1. Interacts with YWHAZ. Interacts (via death domain) with KIF1B; links the motor KIF1B to Rab3-carrying vesicles in anterograde synaptic vesicle transport. Interacts with KIF1A. Interacts (via uDENN domain) with RAB3A, RAB3B, RAB3C and RAB3D; the GTP-bound form of the Rab proteins is preferred for interaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010968">
        <property type="protein sequence ID" value="GCB80473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q515"/>
    <dbReference type="STRING" id="75743.A0A401Q515"/>
    <dbReference type="OMA" id="PEGCYNT"/>
    <dbReference type="OrthoDB" id="6282239at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000002">
        <property type="entry name" value="MAP kinase-activating death domain protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039980">
        <property type="entry name" value="MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="15">
        <location>
            <begin position="12"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="671"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB80473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="719" mass="80828" checksum="6261053B4C4C06E3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q683</accession>
    <name>A0A401Q683_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026360">
        <property type="protein sequence ID" value="GCB80904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q683"/>
    <dbReference type="OrthoDB" id="8960773at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039861">
        <property type="entry name" value="IMPG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12199">
        <property type="entry name" value="INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12199:SF5">
        <property type="entry name" value="MUCIN-2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="201" mass="22607" checksum="1389F4DF39E7CEEC" modified="2019-05-08" version="1" fragment="single">DQADACKFQACNEFSECRVNRQTEEAECVCHPGYVSVDGLPCQSICNLRPNYCLNNGKCQIDPRKGAVCRCHIESDWLYRGEHCTEPESKPLIIMVTIMSIFGLLLLISTLTLILPKMFHKPVKNKSDRFLHIYGIENKASVNPAFEHDEPLIVDHQQPTDSLSMPSSSSTITAVAAPPQELKKMLENVNFSKEVTESNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6V2</accession>
    <name>A0A401Q6V2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0022963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the IFIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025191">
        <property type="protein sequence ID" value="GCB81100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="interferon-induced protein with tetratricopeptide repeats 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10271">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10271:SF0">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0391">Immunity</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
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            <begin position="248"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
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            <end position="85"/>
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    </feature>
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    <feature type="non-terminal residue" evidence="8">
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        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038336"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB81100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="363" mass="42390" checksum="9CFDE398EE5BE981" modified="2019-05-08" version="1" fragment="single">NAQDDLLNVKLNWLQCHFTWAPQRENIDLDDMKQRLQDSIDLGVKYQARSYNQLAFVNCLQGNCVEAIQNLKEAEKILRENHEDEFDKRSIITYGNYAWVYYHMGQLTEAQSYLDKLERVCKQFPEASRYTAMIPEVYGEKGWSLLSGPGQYYEDAMECFKRALEEDPGNTDWNNRYATVLFRLEWLSGTPESQGPSESMKQFRRVLELDPDHIVAMVLLALKLQQFNQSEEALELIKETLQKSPDLPYVLRYAAKFYRTEGDVEKAVELLKKGLEITPHSTFLHHQIGQCYRTKLYKLINSHNAALQQKGELIEVCKYHFQKAFEKRPLTSIKPHLDFAGICSLNEEHHKAKEIYNHLLTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6Y3</accession>
    <name>A0A401Q6Y3_SCYTO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020006">
        <property type="protein sequence ID" value="GCB81121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10472023at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="51" mass="5384" checksum="8545C05E6D6EED3B" modified="2019-05-08" version="1" fragment="single">MKPSSGNRSGQGSFDISSDLKLVSGVEPSIRINLSEGEGQCEEWLTGSPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q770</accession>
    <name>A0A401Q770_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026578">
        <property type="protein sequence ID" value="GCB81235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401Q770"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12681">
        <property type="entry name" value="RRM_SKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034784">
        <property type="entry name" value="PDIP3_RRM"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="111"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB81235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="186" mass="20421" checksum="2B03215A7AD1D558" modified="2019-05-08" version="1" fragment="single">VLEEEDMEEEDEEILHSIPVTNKPLKIGTVINHLTQKRPGFNAPKLSLGNAVPLTKVVQNDSYTAPPPAPLTLTRSRPPANVSRTAALTAEQDPADDVSPLELNLSPLEGTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVRKDDAITAYKKYNNRCLDGKSVFENTSCWCGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QA92</accession>
    <name>A0A401QA92_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0022307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022044">
        <property type="protein sequence ID" value="GCB82303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QA92"/>
    <dbReference type="STRING" id="75743.A0A401QA92"/>
    <dbReference type="OrthoDB" id="9978677at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990450">
        <property type="term" value="F:linear polyubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20337">
        <property type="entry name" value="BRcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16631">
        <property type="entry name" value="mRING-HC-C4C4_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047540">
        <property type="entry name" value="BRcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026254">
        <property type="entry name" value="RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032065">
        <property type="entry name" value="RNF31-UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047541">
        <property type="entry name" value="RNF31_RBR_mRING-HC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057426">
        <property type="entry name" value="RNF31_UBA_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004">
        <property type="entry name" value="RING FINGER PROTEIN 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16678">
        <property type="entry name" value="UBA_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25163">
        <property type="entry name" value="UBA_RNF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="203"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB82303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43402" checksum="D2612E47E36F4069" modified="2019-05-08" version="1" fragment="single">KGEEQQCSPEEVFCALQCSGEEDPVAWLQTELPQVLENITDLASQKGEAMVENEVGPVTRGEARQAWLDCGGDFEEAVRECVRTRARKFREIRAMGFADQQEVLQALYMNGGDVNKAVIDLQRQLLEPFHTQIWQETEVGIQLDQPDKQRIVRQILATYNLPSWGRAEIVLSLMQEGRDHFQIHDVVEAVKESQDKEFIKRMLSLTCLVCLSLFPRNKMQSVTSCECTVCRDCFKEYFTFTVREKNIKNLVCPGCSKPDIDDEGQLLVYFSTLDVQLRDCLDVDVYNLFHKKLTERTLMKDPKFKWCTHCSNGFIYDGNQSKVTCPQCKGSFCVECKRPWESQHQGITCEEFQNWKRENDPEYQAQGLAAYLKENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAH3</accession>
    <name>A0A401QAH3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endosome-associated-trafficking regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0023075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENTR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026010">
        <property type="protein sequence ID" value="GCB82356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAH3"/>
    <dbReference type="STRING" id="75743.A0A401QAH3"/>
    <dbReference type="OrthoDB" id="6499155at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903566">
        <property type="term" value="P:positive regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026757">
        <property type="entry name" value="ENTR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31259">
        <property type="entry name" value="ENDOSOME-ASSOCIATED TRAFFICKING REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31259:SF3">
        <property type="entry name" value="ENDOSOME-ASSOCIATED-TRAFFICKING REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB82356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="239" mass="27196" checksum="B2EFC1F6E1E680B0" modified="2019-05-08" version="1" fragment="single">MYNVFIPPSLIPQNPAGISFEGGTTAPKGLSLSLHFPERHFPDLKAHSPSLEDEDDDWSETYQPAVIEAAHEFSFSDTLRGVSYLPLTLNPAELPQQDTVQFTPSEWLVDEEEEEEGSPEEGEEKDYIFGEKTSQPGAPCDEPDPPRDHFDLVGEVLYQSQLLTNEKASSIQTKILQLQEENAKLRKQNKEAKQVVKVHVQRTKRLEEALEKRKIKEEKETRALESMVQHVEENLQLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAZ1</accession>
    <name>A0A401QAZ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022199">
        <property type="protein sequence ID" value="GCB82532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAZ1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019075593" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10251" checksum="C8246F05B74FDCD8" modified="2019-05-08" version="1" fragment="single">MCPLNLIKRFLVLLLRQNELVMMPSTVKRCASNQCHIEHDERLRLCTRPILQQETTTQPQSSEEEGKTEAASQEIVKPEHYIKHPLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QET6</accession>
    <name>A0A401QET6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01048679">
        <property type="protein sequence ID" value="GCB83928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QET6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="11578" checksum="ABD1843BE9AEE88A" modified="2019-05-08" version="1">MVSEEVVSEEMASEEVLSEVLVVSEEVGSVELVSKEIVSEEMVSEEMASEEMLSEEMASEEMLSEELVSEEMVSEEVVSEEMVSEDMVSEEMMHEEMPVMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFF3</accession>
    <name>A0A401QFF3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0024624</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01051811">
        <property type="protein sequence ID" value="GCB84072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFF3"/>
    <dbReference type="STRING" id="75743.A0A401QFF3"/>
    <dbReference type="OMA" id="LCMAREE"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051505">
        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789:SF4">
        <property type="entry name" value="ENDOSIALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001775">
        <property type="entry name" value="CD93/CD141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019033523" description="C-type lectin domain-containing protein" evidence="15">
        <location>
            <begin position="19"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="17">
        <location>
            <begin position="32"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB84072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48482" checksum="DC64A6A911099E53" modified="2019-05-08" version="1" fragment="single">MLLLGLAVLWLSAGCAWQEPAPAHTICSPEACYTAHLRRRSFNEAWRACRERGGNLASIKRQREAELVEELMQGLSLSEEQGELKLWLGLQRQPRQCSPYKSLRGFTWTTGDQGTWYTNWLKEEYPGSCAATRCVVLSFGAGEAARHANYKWLDGSCQLAVDGYLCRFSYRGMCEPIELGARGPVVYDTPFGVTSSRLRHIPFGSVATLPCGGPRGAQSLLCMAREEEERRGGGGGGGGGGVGWSRDPPYCQEARPRSGCAADNGGCGQTCVDEGAYYHCQCDEGYQLDADGRSCSPLDGCAGGPCQFYCLSGPGGFACSCPEGYRLAKDGRSCLDVDECVSAPCGQDCANTLGSYLCRCHEGYQLEEGECRDVDECVGMPCGQLCANTEGSFQCYCEVGFTLSEEDAATCSDVDECHYQGSCQQMCVNYLGHYECHCEEGYALDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGD8</accession>
    <name>A0A401QGD8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01076460">
        <property type="protein sequence ID" value="GCB84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGD8"/>
    <dbReference type="OrthoDB" id="5519333at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027861">
        <property type="entry name" value="TMEM249"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35442:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT TMEM249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35442">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15158">
        <property type="entry name" value="TMEM249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="93" mass="10959" checksum="C31A588BD7F810DC" modified="2019-05-08" version="1" fragment="single">ITIDLLQWRFPGQGKFYYKLILNGTYIEVISLTGIKFSTNREKLEKLGMRLAAKLNLNYFDCVDLTTKHVIRHWPQHKSKDTAKETKDWDLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJI0</accession>
    <name>A0A401QJI0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01175209">
        <property type="protein sequence ID" value="GCB85540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJI0"/>
    <dbReference type="STRING" id="75743.A0A401QJI0"/>
    <dbReference type="OMA" id="EMFLQEC"/>
    <dbReference type="OrthoDB" id="10426050at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="10269" checksum="815E823CB087C2FA" modified="2019-05-08" version="1">MVGSRSGGGGGGGGAAAGRAKFSVEELYGLNNNKKPKCMGPPIKSAMGKSFGLRADQVTEDDRRLLEERRLEMFLQECQLSLDQTVAERTGMVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJJ3</accession>
    <name>A0A401QJJ3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01176677">
        <property type="protein sequence ID" value="GCB85551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJJ3"/>
    <dbReference type="STRING" id="75743.A0A401QJJ3"/>
    <dbReference type="OrthoDB" id="9950129at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="452" mass="49794" checksum="CEA9D1A303DC9651" modified="2019-05-08" version="1" fragment="single">PPQGPQPPPKEPADSGYDTETALSPDLSLKEAAADRGDAPRGRSAAPPVPDGLRPLGEGTPYRDSAYFSDQEGELDRARGPVPTGRGSGKGELLEDEEEDEEEEGRRKIEEWENLKNEYLTGRGKGKGEPWGSEGTEVMTSGPPINIVQVRMFLEQREPIRDLIKDQQPIRDLIEEREPIRDLIEDREPIRELDGALMPARDPIERREPIGDLAGEHGPRRHVVEHDEPIKTLVEHGEPTRGRATRQEPIKNLVEYQQRIAGLGGEQESISGLVGCQKQIPGLDEDPEPIPVPVGDMESIPSLVEEQEPIPGLGEDPDPIPVLVGEQDAIPALVEEQEPIPGLREEQEPIPALGEEQGPIPDLREEQEPIPALGEEQEPIPGIREEQEPIPALGDEQEPIPDLREEQEPIPALGEEQEPIPALGEEQEPIPGLCDEQEPISALREEQEPIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKI8</accession>
    <name>A0A401QKI8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01214201">
        <property type="protein sequence ID" value="GCB85874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKI8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="15658" checksum="75F88908C3C17838" modified="2019-05-08" version="1" fragment="single">SITIGRHELTPYRDVSIVDTDDLERTDDDQRIHQYGQKGLPCIPRLRADWEGLQEAATPFGQLWNKQRERNQTHAEKAAELFQYTEHFLYNVELGTECQYPSMDTYYFTCCCTFVAVEIVRLFYYALLPQTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLH1</accession>
    <name>A0A401QLH1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromodomain-helicase-DNA-binding protein 6-9 tri-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01250793">
        <property type="protein sequence ID" value="GCB86229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLH1"/>
    <dbReference type="STRING" id="75743.A0A401QLH1"/>
    <dbReference type="OMA" id="WTSREES"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051493">
        <property type="entry name" value="CHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056342">
        <property type="entry name" value="HTH_CHD6-9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23078">
        <property type="entry name" value="HTH_CHD6-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromodomain-helicase-DNA-binding protein 6-9 tri-helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="137" mass="16631" checksum="46236E77F1FBA87D" modified="2019-05-08" version="1" fragment="single">MGLHNRPRYWPTPSALTARLRRLVTAYQRTYKQEQQKVEAAEKGDRRRRRCEAAFKLKEIARREKRQKWTSREESDFYRVVSTFGVEFDPQNRLYQWGRFRAIARLERKSDETLTKYFQMFMAMCRRVCGLPLEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM17</accession>
    <name>A0A401QM17_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leprecan-like alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0027107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01284653">
        <property type="protein sequence ID" value="GCB86425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM17"/>
    <dbReference type="STRING" id="75743.A0A401QM17"/>
    <dbReference type="OrthoDB" id="8517835at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986:SF8">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986">
        <property type="entry name" value="PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Leprecan-like alpha-helical" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB86425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="55" mass="6400" checksum="AEF89F632186F703" modified="2019-05-08" version="1" fragment="single">IKKLGKAVAAAYTFYVVNPEHLEMRQNLEYYRLMAGVKDSDFKDLEAKPHMVITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM79</accession>
    <name>A0A401QM79_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01295935">
        <property type="protein sequence ID" value="GCB86484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QM79"/>
    <dbReference type="OMA" id="ETAVYCD"/>
    <dbReference type="OrthoDB" id="7467016at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="285" mass="31634" checksum="91E3AC4FBD7A5815" modified="2019-05-08" version="1" fragment="single">MEIAVFYSLIEIAVLYSLMEIAVFYSLMEIAVFYSLIEIAVFYSLIEIAVFYSLIEIAVFYSLIEIAVFYSLIQIAVLCSLIQIAVFYSLIEIAVLCSSIEIAALCSLIEIAVFYSLLESAVFCSLIEIAVFCSLMEIAVVHSFIGIAVFYSLMEIAVFYSLIEIAVSYRLIEIAVIYSILVFAVSYSLIEIAVLCSLIEIAASCSLIEIAVFCSLMEIAVLYSLMEIAVIYSLIEIAVIYSILVFAVYYSLIAFAVFCSLIEIAVFCSLTEIAVFYSLMGIAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMF0</accession>
    <name>A0A401QMF0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
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                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01294548">
        <property type="protein sequence ID" value="GCB86478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMF0"/>
    <dbReference type="OMA" id="CRMGAGC"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="177" mass="18572" checksum="2275481ECF6B08BB" modified="2019-05-08" version="1">MGKWAESGMSGLDMGECEGLGMSKLNMGKWEGLGMSKLNMGKWEGLGMSGLDMGACEGLGMSGLDMGRWAGLVMSGLDIGKCEGLGMCGLDLGTCEGLGMSKLDMGKWEGLGMSGLDMGKWEGLGMSELDMGKREGLGMSKLNMGEWEALGMSGLDMGKWEGLGLSGLDMGKHEGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNE7</accession>
    <name>A0A401QNE7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">Cloudy catshark</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
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                <person name="Kiyatake I"/>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01367371">
        <property type="protein sequence ID" value="GCB86842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNE7"/>
    <dbReference type="OMA" id="QVRDQEW"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="8569" checksum="2D66365B82FD139A" modified="2019-05-08" version="1" fragment="single">IQEQIQEQIQEQIQEQIQEQIQKQTQEQIQEQIQEQIQEQIQEQIQEQIHDQIDEQIQKQIQEQIHDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNS0</accession>
    <name>A0A401QNS0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01400405">
        <property type="protein sequence ID" value="GCB87077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNS0"/>
    <dbReference type="OMA" id="HWLSNER"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16249" checksum="8F6D3F4B80D6446F" modified="2019-05-08" version="1">MARQIGRMARQTGRVARQTGRVARQIGRMARQTGRLACQTGRVTRQMGIVARETDGESGTQTGRVARQTGRVARQTGRVARETGRLACQTGRVARQTGRVARQGGRVAREIGRLARQMGRVARETDRVARQMGRVAHQMGRVARETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGW3</accession>
    <name>A0A401NGW3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0012660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/PBX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006184">
        <property type="protein sequence ID" value="GCB60026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGW3"/>
    <dbReference type="STRING" id="75743.A0A401NGW3"/>
    <dbReference type="OMA" id="MVGTMDP"/>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000008">
        <property type="entry name" value="Pre-B-cell leukemia transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005542">
        <property type="entry name" value="PBX_PBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03792">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51978">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PBC" evidence="11">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="343" mass="37678" checksum="88858A450947D9E0" modified="2019-05-08" version="1" fragment="single">TVLSIRGVQEEEPPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSPNDHSIEHSDYRAKLTQIRQIYHSELEKYEQACSEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFNTIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAADATTVVAHQGSQANSPSTPNSGSSGSFNMPNSGDLFMNMQSLNGDSYQSSQVGANVQSQVDSLRHVIHQTGGYSDEMAVSQMYTPRRIDANGSWQDATTPSSVTSPTGGPGSVNSDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGY5</accession>
    <name>A0A401NGY5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007432">
        <property type="protein sequence ID" value="GCB59981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGY5"/>
    <dbReference type="STRING" id="75743.A0A401NGY5"/>
    <dbReference type="OMA" id="YCEVAWH"/>
    <dbReference type="OrthoDB" id="309339at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000237">
        <property type="entry name" value="Bardet-Biedl syndrome 4 (Human)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB59981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="452" mass="51550" checksum="5400B3A43B2AB3EE" modified="2019-05-08" version="1">MAESTMQRSDVRKSQSRKVPELPILERRNWLIHLHYIRKDYETCKAIIKEQLQETQGMCEYAVYVQALIFRLEGKIQESLELFQTCAILNPQNMDNLKQVARSLFLLGKHKAATEVYSEAAKLNEKDWEISHNLGVCFMHLKNFEKAKEYLTCALQTSRHDLTFILLGKLHLLEGNTQNAIETYKRAVEFSPENAELLTTLGLLYLQLGMYQKAFEHLGNALTYNPNNYKAILAAGSMMQTHSDFDVALSKYRIAAHAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQHASAFHFLSAAINIQPRMGELYMLLAVTLTNLADPDNAKRAYERAVSLEQLNPLVNLNYSILLYNQGDRKGALHQYQEMEKKVLKLKASSNVLEFDPECENQMRSGEQLAFAALLCFPITARNVERASSICELSFCTNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHJ7</accession>
    <name>A0A401NHJ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GMP phosphodiesterase delta subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003662">
        <property type="protein sequence ID" value="GCB60340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHJ7"/>
    <dbReference type="STRING" id="75743.A0A401NHJ7"/>
    <dbReference type="OMA" id="IYNIEFT"/>
    <dbReference type="OrthoDB" id="10248777at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000001">
        <property type="entry name" value="protein unc-119 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051519">
        <property type="entry name" value="PDE6D_unc-119_myristoyl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF1">
        <property type="entry name" value="PROTEIN UNC-119 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951">
        <property type="entry name" value="RETINAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="6">
        <location>
            <begin position="69"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="232" mass="26748" checksum="7B44A29B31B297D9" modified="2019-05-08" version="1">MSDSDNRADGTELKKEGGSVLNRMKSRRNPEPEGLTPITEAELLQKDCISPLNVLCLQTATESYLCKPEDNIYNIDFTRFKIRDMETGTVLFEIAKPPASELEEDNDDENGEMDSSSGRFVRYQFTPAFLRLRTVGATVEFTVGDKPVSSFRMIERHYFRERLLKSFDFDFGFCIPNSRNTCEHIYEFPQLSEDIIQEMVVNPYDTRSDSFYFVDSRLIMHNKADYAYNGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIH7</accession>
    <name>A0A401NIH7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thymidine kinase</fullName>
            <ecNumber evidence="11">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0006906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19130"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer. Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine. Tetramerization is inhibited by phosphorylation at Ser-13. Interacts (via the KEN box) with FZR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01002414">
        <property type="protein sequence ID" value="GCB60669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIH7"/>
    <dbReference type="STRING" id="75743.A0A401NIH7"/>
    <dbReference type="OMA" id="SCYFAND"/>
    <dbReference type="OrthoDB" id="439028at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000028">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB60669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="175" mass="19725" checksum="36E8DCE2FDD25E84" modified="2019-05-08" version="1" fragment="single">TELMRRVRRFQIAQYDCLVVKYAKDTRYSKEDLATHDKLTMQAVPATKLSEVFQEAEKSSVIGIDEGQFAFGNILNLVPLAESVVKLSAVCTKCYGEAAYTKRLGAEQEVEVIGGTDMYRATCRSCYFANDKLFDMGSNKENSEEEGTDQHVALKHLISTQQSKPQRKLFESLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLL4</accession>
    <name>A0A401NLL4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0007111</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 13">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002516">
        <property type="protein sequence ID" value="GCB61773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLL4"/>
    <dbReference type="STRING" id="75743.A0A401NLL4"/>
    <dbReference type="OMA" id="NDKYEDM"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000091">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000005">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000006">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="15">
        <location>
            <begin position="368"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB61773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="753" mass="87261" checksum="AED08FEB5AB2033E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMD3</accession>
    <name>A0A401NMD3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007734">
        <property type="protein sequence ID" value="GCB62012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMD3"/>
    <dbReference type="STRING" id="75743.A0A401NMD3"/>
    <dbReference type="OMA" id="EEAANWY"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="465"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="757" mass="84621" checksum="01E000015DEFCAB6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNU5</accession>
    <name>A0A401NNU5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0014507</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007807">
        <property type="protein sequence ID" value="GCB62532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNU5"/>
    <dbReference type="SMR" id="A0A401NNU5"/>
    <dbReference type="STRING" id="75743.A0A401NNU5"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="127" mass="13377" checksum="865AC88F6832F437" modified="2019-05-08" version="1" fragment="single">AGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQY1</accession>
    <name>A0A401NQY1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0013187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006638">
        <property type="protein sequence ID" value="GCB63298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQY1"/>
    <dbReference type="STRING" id="75743.A0A401NQY1"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF24">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB63298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="17173" checksum="8D6C19077F91C9B6" modified="2019-05-08" version="1">MAGFGVGGLVFNVCLLLLALVGMYRLYRRRRAGSETESKEPELPKMKKRDFSLEQLREYDGVQNPRLLLAVNGKVFDVTKGKKFYGPGKEQHMNRGVYIHSCNTIFASIARETLHVVAKLLQNYSFVKQSINSVIMVCYNWREYFKGDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQZ6</accession>
    <name>A0A401NQZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator complex subunit 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007906">
        <property type="protein sequence ID" value="GCB63300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQZ6"/>
    <dbReference type="STRING" id="75743.A0A401NQZ6"/>
    <dbReference type="OMA" id="GPVPNQM"/>
    <dbReference type="OrthoDB" id="10055322at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048386">
        <property type="entry name" value="Med15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048385">
        <property type="entry name" value="Med15_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21539">
        <property type="entry name" value="Med15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21538">
        <property type="entry name" value="Med15_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARC105/Med15 mediator subunit central" evidence="3">
        <location>
            <begin position="377"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ARC105/Med15 mediator subunit C-terminal" evidence="4">
        <location>
            <begin position="523"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB63300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="69690" checksum="5113AF98BB181078" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRH9</accession>
    <name>A0A401NRH9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CYRIA/CYRIB Rac1 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0000158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000025">
        <property type="protein sequence ID" value="GCB63457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRH9"/>
    <dbReference type="STRING" id="75743.A0A401NRH9"/>
    <dbReference type="OMA" id="LVDKTHY"/>
    <dbReference type="OrthoDB" id="60973at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="GH09096P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB63457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="12016" checksum="A29D84392CEA7EF4" modified="2019-05-08" version="1">MRPGNTRMLLGKPLAVKGEYKSRFTNDETLLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPPNNVEGLLNALRYTTRHLNDESASKQIRTMLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT99</accession>
    <name>A0A401NT99_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0013286</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01006736">
        <property type="protein sequence ID" value="GCB64123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT99"/>
    <dbReference type="STRING" id="75743.A0A401NT99"/>
    <dbReference type="OMA" id="QLANKFE"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000045">
        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000054">
        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000077">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="56"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="377"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="440"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB64123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="541" mass="60279" checksum="AB9785BF02421C6F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUQ7</accession>
    <name>A0A401NUQ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0013357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006783">
        <property type="protein sequence ID" value="GCB64562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUQ7"/>
    <dbReference type="STRING" id="75743.A0A401NUQ7"/>
    <dbReference type="OMA" id="HKQLKCC"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="249" mass="27738" checksum="7CAC0D415CB9FEB6" modified="2019-05-08" version="1">MCGTARISKLLLAVVGPLLSGSAVVPGLGGLFLLFINRSYRHFIGNDYLLLPASLSFVVAGLLLLTGIIGLCVAVNQSHCLRGTFLYLVLILFGLEVTTGTLGYINSVRVMPADLDRFNEIFRKYSDNDSMIESRAVDRLQQNMHCCGVRNYTDWTQFPWFVQSGNDSVPQSCCARNFTTCRGDMEEPELLYTQGCLLTLRDELQWIFLFTLGWVVAVCCLQTLGALMICLWTNTDSAPYQLLNTDNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV61</accession>
    <name>A0A401NV61_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear transport factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0004656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001392">
        <property type="protein sequence ID" value="GCB64747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NV61"/>
    <dbReference type="STRING" id="75743.A0A401NV61"/>
    <dbReference type="OMA" id="SFIPHYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000007">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="156" mass="17449" checksum="899DDF310E6046AF" modified="2019-05-08" version="1" fragment="single">RGWEGPGAVGRHTAIGRSLGRWVPVAVIRMGDKPLWEQIGSGFVQHYYQVFDADRSQLGSLYIDASCLSWEGQQFQGKTAIVEKIIGLPFRKIQHSITAQDHQPTPDSCILSMVVGQLQADEDPVMGFHQIFLLKNINDAWVCTNDVFRLALHNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV98</accession>
    <name>A0A401NV98_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonucleoprotein PTB-binding 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Protein raver-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0000327</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000061">
        <property type="protein sequence ID" value="GCB64774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NV98"/>
    <dbReference type="STRING" id="75743.A0A401NV98"/>
    <dbReference type="OMA" id="FADQHSQ"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000100">
        <property type="entry name" value="Putative ribonucleoprotein PTB-binding 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000116">
        <property type="entry name" value="Putative ribonucleoprotein PTB-binding 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000125">
        <property type="entry name" value="Putative ribonucleoprotein PTB-binding 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="48"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB64774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="784" mass="85163" checksum="B82B0DFE9478C520" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWL9</accession>
    <name>A0A401NWL9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002829">
        <property type="protein sequence ID" value="GCB65269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWL9"/>
    <dbReference type="STRING" id="75743.A0A401NWL9"/>
    <dbReference type="OMA" id="TADRYWA"/>
    <dbReference type="OrthoDB" id="5175656at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF7">
        <property type="entry name" value="SECERNIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16553" checksum="3383C57EFBE24F4C" modified="2019-05-08" version="1" fragment="single">LGLERGTTAKESLDIMVSLLEEHGQGGNNFEDGATLHTFHSTFLIVDRTEAWVLETADRYWAAEKITEGLRSICNQLSITTNIDAEHPELRGYAESQGWWNGEEEFNFSAVFSAPGGDEALGHHCTGKELLQKHSGNITVQMMMDALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWS1</accession>
    <name>A0A401NWS1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytosolic arginine sensor for mTORC1 subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0007689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GATS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002834">
        <property type="protein sequence ID" value="GCB65321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWS1"/>
    <dbReference type="STRING" id="75743.A0A401NWS1"/>
    <dbReference type="OMA" id="EEPTANW"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000003">
        <property type="entry name" value="Cytosolic arginine sensor for mTORC1 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000004">
        <property type="entry name" value="Cytosolic arginine sensor for mTORC1 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049479">
        <property type="entry name" value="CASTOR1_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040778">
        <property type="entry name" value="CASTOR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026249">
        <property type="entry name" value="CASTOR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF2">
        <property type="entry name" value="CYTOSOLIC ARGININE SENSOR FOR MTORC1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21389">
        <property type="entry name" value="CASTOR1_ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18700">
        <property type="entry name" value="Castor1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02078">
        <property type="entry name" value="GATSLIKEFMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR1 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CASTOR ACT" evidence="4">
        <location>
            <begin position="72"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosolic arginine sensor for mTORC1 subunit 1/2 ACT-like" evidence="6">
        <location>
            <begin position="177"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CASTOR ACT" evidence="4">
        <location>
            <begin position="261"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36163" checksum="FC2A96C7C651558A" modified="2019-05-08" version="1">MELHILEHRLKVASIAKDGIQLFTHGLIKLAFLPSKTRCKFFSLTETPEDYTIIVDEEGFKELPGSDLLSVADETWLALNVVSGGGSFSSSQPIGVTKIAKSVIAPLADHNISVFMLSTYQTDFILVRERDLPLVMHTLSAEFTILRVVNGETVAADHLGITNGFVKPKLVQRPVIHPLSSPSNKFCVTSLDPDTLPTVATLLMDVMFYSNGMKDSAIGSDENGHIRFFSFSLIEGYISLVMDVQTQQRFPNNLLFTSASGELWKMVRIGGQPLGFDECGIVAQIAEPLAAADIPAYYISTFKFDHALVPEENINSVINALQVSQNKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX49</accession>
    <name>A0A401NX49_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0009958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004201">
        <property type="protein sequence ID" value="GCB65446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX49"/>
    <dbReference type="STRING" id="75743.A0A401NX49"/>
    <dbReference type="OMA" id="DIEWERT"/>
    <dbReference type="OrthoDB" id="9904387at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF151">
        <property type="entry name" value="ICOS LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="172"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="268"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="397"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="489" mass="55370" checksum="6EB0B865F5484ED2" modified="2019-05-08" version="1">MFIFRCMVEGKVQVADRIIKAITIDRIMRLLPIIYLHALYLLLHFQSRKMEKLRDLIMIRHESIVGVEEGHQFTASCRFSDIISKSGSFDIEWERTKEGHTLERLLHHSISPNEETVQYLSEKVKTRVHGSYLNASFSNLNLNPTLLEDSGKYFCYVNGLKSLTITLFVCIPFKDIFVDYEPKEVVEGTKVSIYCAAKEGFPEPLVQWIAAGEDITKEAITVTEILPGKIFDVKSSVVVTVKKGVKYICSIWNKHIENLLVDWVLPLPGVTVSTPYKNIVGIAGSSVELICDVSIPESDPVTIAELGFYWVNMDPNSKEHLIYSFVNEEENLDGQDLRYENRAFLYWEDFLEGSPDLKIKDVSIEDMGVYICRVTKREKLIGEDLLELRVAAPYSNPVITYGQHATNFRNVFLICQTKGGFPLGNISWLADNGNDITARSKTNAKLSDGYFDFRSGLHVSVAEGTRFTCVISNPWLPDKSSSTVTFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY72</accession>
    <name>A0A401NY72_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L32, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0010011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004233">
        <property type="protein sequence ID" value="GCB65805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY72"/>
    <dbReference type="STRING" id="75743.A0A401NY72"/>
    <dbReference type="OMA" id="CKETGLI"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB65805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="20250" checksum="086239A521F43A44" modified="2019-05-08" version="1">MASLQRLFPSWSTLERALLQGLGLQQRLAPALAIQAPVDFPQPEAESRDKDQSDSPSFLESIFWMAAPKKRRTIEVNRCRRRDVRKLEKVKNNIEVCQDCGNLKLKHVLCAFCYQKVVQETALVRAQIQAQEGRPLNTPPIETVMLYKEEKATEADEGKRIIERNQKRPSWFTVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ13</accession>
    <name>A0A401NZ13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">KCNMB2 ball/chain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0010050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004257">
        <property type="protein sequence ID" value="GCB66109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ13"/>
    <dbReference type="OMA" id="HKDYAAT"/>
    <dbReference type="OrthoDB" id="5962477at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005513">
        <property type="term" value="P:detection of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003930">
        <property type="entry name" value="K_chnl_Ca-activ_BK_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258:SF5">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03185">
        <property type="entry name" value="CaKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB66109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30829" checksum="50813250AA2EF2E4" modified="2019-05-08" version="1" fragment="single">SQEATEKDRNIYSCKSSTCLLTMSLRRNVISSSPVRYTSAGSMSRMFLWSRQQHRRQQGRSKIKFTPSDLEKWNAVSALKAGEDRATYLGLGMLICSIVLAFLLGTKLVRSYNESVWKGESKCTVIETRITNCKNCIQSCVSNCQKALHYPCIQIYVNLSASGSRALLHLSEDSVRVNSECFCATKCNINYSETEMLIASITENNTQSQPNPFSCYYDPEGQQNNVLLTRFDLPTALLNSAFWPMCMFACGTVIIIMVKMTQYLSLLKEHLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1U6</accession>
    <name>A0A401P1U6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002992">
        <property type="protein sequence ID" value="GCB67119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1U6"/>
    <dbReference type="STRING" id="75743.A0A401P1U6"/>
    <dbReference type="OMA" id="QSISIDW"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032738">
        <property type="entry name" value="Tbc1d30_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399:SF4">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15733">
        <property type="entry name" value="DUF4682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="30"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="666" mass="75164" checksum="FC6F8E00C139A11F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2H3</accession>
    <name>A0A401P2H3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gp5/Type VI secretion system Vgr C-terminal trimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005761">
        <property type="protein sequence ID" value="GCB67334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2H3"/>
    <dbReference type="STRING" id="75743.A0A401P2H3"/>
    <dbReference type="OMA" id="KDHEGMM"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054030">
        <property type="entry name" value="Gp5_Vgr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35245:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22178">
        <property type="entry name" value="Gp5_trimer_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp5/Type VI secretion system Vgr C-terminal trimerisation" evidence="1">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="526" mass="62057" checksum="74BB1F722FD78C8B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2L7</accession>
    <name>A0A401P2L7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007101">
        <property type="protein sequence ID" value="GCB67385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2L7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7381" checksum="7668C27CC5260FC9" modified="2019-05-08" version="1" fragment="single">MLSKPVLLSQEAINMYKASEQASSEYAEFVATEKGAKTGNEVNTIDVMSQYSISAECYFTDDITSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2S0</accession>
    <name>A0A401P2S0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003018">
        <property type="protein sequence ID" value="GCB67412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2S0"/>
    <dbReference type="STRING" id="75743.A0A401P2S0"/>
    <dbReference type="OMA" id="GCVFLHQ"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03449">
        <property type="entry name" value="R_hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000042">
        <property type="entry name" value="MaoC domain protein dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050965">
        <property type="entry name" value="UPF0336/Enoyl-CoA_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43437:SF3">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43437">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="172" mass="19119" checksum="D41946FAD073CE6F" modified="2019-05-08" version="1">MPFGAQRVIRSIFQSPLKMSQWHAGSILTLQNAFLRSMHLQVGERLELTKAFTQNDVFAFSELTGDMNPLHFSEDFAKANKFGKPVVHGVLVCGLMSAVLGTKMPGCVLLSQDLRYLAPLYIGERVSAIADVIKVRRSIAWIAVSCIVKETEKVIMKGEVKIMLPEGRNQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2W3</accession>
    <name>A0A401P2W3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="4 14">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0013705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="4 14"/>
    <dbReference type="EMBL" id="BFAA01007112">
        <property type="protein sequence ID" value="GCB67468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2W3"/>
    <dbReference type="STRING" id="75743.A0A401P2W3"/>
    <dbReference type="OMA" id="GMVPQVW"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000007">
        <property type="entry name" value="Protein-S-isoprenylcysteine O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB67468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="282" mass="31736" checksum="5ED2D04C9BAA56B7" modified="2019-05-08" version="1">MAGGRLVAEGRLSAGCFALGVSVTLVPGLSGIQSGFVTRALLGTYLAVINVLLLLLYRGLHYQVAVRACFLGFVCGCGLLLSFGGSSWQHFGWYLCSLSIFHYSEYLVTAVINPKSLSLDSFLLNHSVEYKLAAMSSWVEFTIEKLLFPGLKQITWLSFFGLLMVLVGELLRKAAMLTAGSNFNHIVQNEKAETHRLVTTGIYSWSRHPSYVGWFYWSIGTQIILCNPICVVGYTLASWRFFRERIEEEEMTLIQFFGEDYEHYKKRIPTRLPFIKGAKLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3S9</accession>
    <name>A0A401P3S9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004406">
        <property type="protein sequence ID" value="GCB67750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3S9"/>
    <dbReference type="STRING" id="75743.A0A401P3S9"/>
    <dbReference type="OMA" id="CERTIHT"/>
    <dbReference type="OrthoDB" id="9944680at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF46">
        <property type="entry name" value="INTERFERON GAMMA RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019030492" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon/interleukin receptor" evidence="5">
        <location>
            <begin position="134"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB67750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43516" checksum="E34409DB0BAD3960" modified="2019-05-08" version="1">MAAAFRAFLTAVLTVQAFGEIQRPTNLQIRAFNLNYVLKWDDVQRSYYSVNYTVQYKRLFQQAQQVNSTVNQNMRLGNWKDVKGCETISHTECDFTSTDIIFLGQYILRVRAQRGNQSSAWLDSKSFSPYKHNVIGPPSVNVDSKDNLLNVYIVDPQTENNKSIPEAYKGLKYSIIYWKEYSHEINVENGSSKLVSLKLEPWTTYCLRVQLFNPIFHVVGQLSHVVCEKINGATPLWKIVVIFIVSLVIVFSVAVGCSFCIHYVSRCIKYAFFPPHILPEHLQECFNVPSQNAFLELVPEEDAEKCCDQLKVICESESLNSYSSSLTLPHIGNEKNDQSGQTSTDSGQFSNDGSSKSVDTEEFEGRALRELDLHTKLMYFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3X6</accession>
    <name>A0A401P3X6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Thyrotropin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TSHR</name>
        <name evidence="17" type="ORF">scyTo_0012196</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005816">
        <property type="protein sequence ID" value="GCB67834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3X6"/>
    <dbReference type="STRING" id="75743.A0A401P3X6"/>
    <dbReference type="OMA" id="FLICICY"/>
    <dbReference type="OrthoDB" id="5981530at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004996">
        <property type="term" value="F:thyroid-stimulating hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15964">
        <property type="entry name" value="7tmA_TSH-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000019">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002274">
        <property type="entry name" value="TSH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF0">
        <property type="entry name" value="THYROTROPIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01145">
        <property type="entry name" value="TSHRECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="247"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB67834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="580" mass="65214" checksum="3655CADBB9AEED16" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5T8</accession>
    <name>A0A401P5T8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008526">
        <property type="protein sequence ID" value="GCB68440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5T8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="16829" checksum="C4C1650F8C8A1B23" modified="2019-05-08" version="1" fragment="single">GVNCEQNYNDCFIYACPVGSECVDGLNSVMCLPGEPTISTKNSVMATAAGTFHLAPTMVPAVPWSGVSQEGEESQSNSSDLEDVWPSIIPSSVHGPAISLTTVSIAMVVSCADDPCPNGTTCEDLDIGKVKCHCSSLHGGESCKAGTIIQDSLMYYRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P672</accession>
    <name>A0A401P672_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005901">
        <property type="protein sequence ID" value="GCB68608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P672"/>
    <dbReference type="STRING" id="75743.A0A401P672"/>
    <dbReference type="OMA" id="XKEFFVE"/>
    <dbReference type="OrthoDB" id="10249775at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="253"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="528" mass="60687" checksum="F27C6D00FF125449" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6F0</accession>
    <name>A0A401P6F0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thioredoxin reductase 1, cytoplasmic</fullName>
            <ecNumber evidence="10">1.11.1.2</ecNumber>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Peroxidase TXNRD1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Thioredoxin reductase TR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0008263</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>H2O2 + NADPH + H(+) = NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:15173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.11.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:15174"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:20347"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.2" evidence="10"/>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01003131">
        <property type="protein sequence ID" value="GCB68704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6F0"/>
    <dbReference type="STRING" id="75743.A0A401P6F0"/>
    <dbReference type="OMA" id="IIEGCEP"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050137">
        <property type="term" value="F:NADPH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000190">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000004">
        <property type="entry name" value="Thioredoxin reductase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF8">
        <property type="entry name" value="THIOREDOXIN-DISULFIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 20" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="22">
        <location>
            <begin position="13"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="21">
        <location>
            <begin position="370"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="19">
        <location>
            <begin position="59"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB68704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="497" mass="53975" checksum="1E18A4F3DE0F411C" modified="2019-05-08" version="1">MNEASESQGPYDYDLIVIGGGSGGLAASKEAAKYGKKVLVLDYVKPTPLGTTWGLGGTCVNVGCIPKKLMHQAAILHQSLQDARTFGWTFDEKVSHDWTTMKDAIGNYIGSLNWGYRVSLKDNGVTYVNAYGEFVGPHKIKGTNKKGKETFYTAETFILATGERPRYLGIPGDKEHCITSDDLFSLPYSPGKTLVIGASYVALECAGFLSGLGLDVTVMVRSILLRGFDQQMANLVGDYLESHGVKIIRQFVPSKIEQIEPGTPGKLKVTAQSTDGSETLEGEYNTVLLAVGRDANTKNIGLETVGVKINEKSGKIPVNDLEQTNIPHIYAIGDLLDGKLQLTPVAIQAGRLLAGRLYNSSSVKCDYANVPTTVFTPLEYGACGYSEEKAIEKYGMENVDTYHSYFWPLEWTVPSRDNNKCYAKIICNKQDQNRVIGFHVLGPNAGEITQGFGAAMKCGMIKEQLDSTIGIHPVCAEIFTTLSVTKQSGKDVQQSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P846</accession>
    <name>A0A401P846_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Next to BRCA1 gene 1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Neighbor of BRCA1 gene 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0012396</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Myofibril</location>
            <location evidence="11">Sarcomere</location>
            <location evidence="11">M line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005979">
        <property type="protein sequence ID" value="GCB69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P846"/>
    <dbReference type="STRING" id="75743.A0A401P846"/>
    <dbReference type="OMA" id="HQKFKLW"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14319">
        <property type="entry name" value="UBA_NBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000033">
        <property type="entry name" value="Next to BRCA1 gene 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000291">
        <property type="entry name" value="Next to BRCA1 gene 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000007">
        <property type="entry name" value="Next to BRCA1 gene 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000199">
        <property type="entry name" value="next to BRCA1 gene 1 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF2">
        <property type="entry name" value="NEXT TO BRCA1 GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="18">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="17">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="890"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="656"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="945" mass="106039" checksum="730AD2EDF35FA24B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8Q3</accession>
    <name>A0A401P8Q3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. BRCC36 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003200">
        <property type="protein sequence ID" value="GCB69464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8Q3"/>
    <dbReference type="STRING" id="75743.A0A401P8Q3"/>
    <dbReference type="OMA" id="CIGEIDT"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08068">
        <property type="entry name" value="MPN_BRCC36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000015">
        <property type="entry name" value="Lys-63-specific deubiquitinase BRCC36 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040749">
        <property type="entry name" value="BRCC36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033860">
        <property type="entry name" value="MPN_BRCC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18110">
        <property type="entry name" value="BRCC36_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="261" mass="29777" checksum="B6C8BE5AEF30C2A8" modified="2019-05-08" version="1">MAVCGVHLDSDAFLVCLNHALSTEKEEVMGLCIGEVDTSRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAEMTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKGSEYERIEIPIHVVPHETIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDPITKIHNGSVFTKNLCSQMSSISGPLLQWLEDRLDQNKQHILELQREKEQLLQELAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8Z7</accession>
    <name>A0A401P8Z7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0005502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001720">
        <property type="protein sequence ID" value="GCB69578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8Z7"/>
    <dbReference type="STRING" id="75743.A0A401P8Z7"/>
    <dbReference type="OMA" id="DTPVEFM"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB69578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="188" mass="21843" checksum="DA5B5FB04BA74DFC" modified="2019-05-08" version="1">MEGYGVIVLNTNENYVEVEKSKKQEQPPPNDTDEPAEKKEKKDDCQKETNKRRDFYEKYRNPQKEKETKHIPIRDNSTPEEHTIYVWDHFISRSSAKNVVFVAHSYGGLVFVELMIQREAEVKSKVISVALTDSVHNVWHQEAGKSILDWMQEHCRNWVSSSEPLDTPVEFMLPDCPRVSAGTLLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9P3</accession>
    <name>A0A401P9P3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0005554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001746">
        <property type="protein sequence ID" value="GCB69871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9P3"/>
    <dbReference type="STRING" id="75743.A0A401P9P3"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="179" mass="20336" checksum="6D9912FB66814C71" modified="2019-05-08" version="1">MELFIVTCTEGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAA3</accession>
    <name>A0A401PAA3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000257">
        <property type="protein sequence ID" value="GCB70066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAA3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="362" mass="41122" checksum="AFA9986CEF5CC117" modified="2019-05-08" version="1">MADNAAKQAVTLEEVGMEHVTVLVITRQMYSDNQDDELRLLISGKTPRGYPSNYNYHCDKMGRVLVSIPGKEAKVQMNTAQQASEGVIPQYNPELAQEMIDLLSQMQPPKPPEPNEWSPQEGDWVQEKKNPKNTLLRPKWKPPVCVKQVQGRMLLVDHGTKGTKLISIDNCRPVPKAFEPQVTTSWYARYEVRSHNEPELDEPPEEIPLTQVTTTPGKTCLKGHPQLLKFKAKVQKNIGSQKRWSKKQKCQCCCLTALGITFSLILFSFILGTITVSLTATQTFDLNSNIGQDLNYTELNNNDKKTGKTDTYYHGKNRTPRSPYLQRRRFNDHGSKMVLSPILTSIPQSGRQELSWFHTPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAL5</accession>
    <name>A0A401PAL5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001776">
        <property type="protein sequence ID" value="GCB70195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAL5"/>
    <dbReference type="STRING" id="75743.A0A401PAL5"/>
    <dbReference type="OMA" id="CEGACAN"/>
    <dbReference type="OrthoDB" id="6233288at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19704">
        <property type="entry name" value="bHLH_TS_TCF21_capsulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF67">
        <property type="entry name" value="TRANSCRIPTION FACTOR 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB70195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="20108" checksum="25491F4748DC9A3F" modified="2019-05-08" version="1">MSTGSVSDVEDLQEMEALGTEEECDGIKGKSNKDFCTSNDSNEDSSNYEHESPKKGRGASGKSRKAASKKSSLNGVTQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPDNELKEVVNTGRLCGTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB85</accession>
    <name>A0A401PB85_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GMP reductase</fullName>
            <ecNumber evidence="1">1.7.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0008562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01003308">
        <property type="protein sequence ID" value="GCB70382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB85"/>
    <dbReference type="STRING" id="75743.A0A401PB85"/>
    <dbReference type="OMA" id="SHTECAG"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF3">
        <property type="entry name" value="GMP REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB70382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16408" checksum="74E380594F7251ED" modified="2019-05-08" version="1">MPFKFTSGLRNYTDVSELEEKERKVESVGSEESTVESAGADFVMLGGMFAGHDQCAGEIIEKNGKKVKLFYGMSSDTAMKKHVGGVAEYRASEGRTVEVPYRGDVENTILDILGGLRSTCTYVGAAKLKELSRRTTFIRVTQQSNQMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBE7</accession>
    <name>A0A401PBE7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centromere protein P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000280">
        <property type="protein sequence ID" value="GCB70442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBE7"/>
    <dbReference type="STRING" id="75743.A0A401PBE7"/>
    <dbReference type="OMA" id="EVFEFKH"/>
    <dbReference type="OrthoDB" id="5976950at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027801">
        <property type="entry name" value="CENP-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28577">
        <property type="entry name" value="CENTROMERE PROTEIN P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28577:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13096">
        <property type="entry name" value="CENP-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26115" checksum="0FEC73626B2A9682" modified="2019-05-08" version="1" fragment="single">LQRPILPGLSELMDQLLHQTYEDEIRSLQEEIRALEQQAESNGIYSDAFLKTIDMQREKFSMQNPQSWKCSYADLEAQLQQTESQIVLLTQLTGIGFTKCTVTAVDKGNKKAKQYRLSGYSHSLQFELEFELTEILTKENVTATVTELNIILESNEFCDLSRFISRAEEKKNLLLFFSTLPTFAKWYEYRQVTFKHFKEKYPEVVRLPEGSNAEYLILECSKLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBJ7</accession>
    <name>A0A401PBJ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0005689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001813">
        <property type="protein sequence ID" value="GCB70491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBJ7"/>
    <dbReference type="STRING" id="75743.A0A401PBJ7"/>
    <dbReference type="OMA" id="ATMVQHY"/>
    <dbReference type="OrthoDB" id="9945442at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000016">
        <property type="entry name" value="B-cell linker protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051751">
        <property type="entry name" value="Immunoreceptor_sig_adapters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098">
        <property type="entry name" value="SH2 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098:SF14">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB70491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="132" mass="15433" checksum="F39F709F4ECA3F48" modified="2019-05-08" version="1" fragment="single">IPKLHFPRLPAKDLERNIWYVGACDRYKAEEALRIKNKNGAFLVRDSSKGIPDKPYVLLVYYRFKVYSIQIRYLEDTKQYALGSGLRGHDIFYSVPDIIEIHKNIPLRLIDRRDQSGSQMEQCILTVPLTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBL2</accession>
    <name>A0A401PBL2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">cAMP-regulated phosphoprotein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0010793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004726">
        <property type="protein sequence ID" value="GCB70505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBL2"/>
    <dbReference type="STRING" id="75743.A0A401PBL2"/>
    <dbReference type="OMA" id="QMAKQNP"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF4">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB70505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13124" checksum="F677B8AFCE46D77D" modified="2019-05-08" version="1">MSSRSEAVRRSQEASAEERQEMDDTVINPEKAEEAKLKLKYPKLGQKPGGSEFLRKRLQKDPKYFDSGDYNMAKAKIKNKQLPNSGADKNQVTGEHIPTPQDLPQRKPSLVASKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCX7</accession>
    <name>A0A401PCX7_SCYTO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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            <taxon>Elasmobranchii</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004797">
        <property type="protein sequence ID" value="GCB70965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="NCBP2-AS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41161">
        <property type="entry name" value="PROTEIN NCBP2AS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41161:SF1">
        <property type="entry name" value="PROTEIN NCBP2AS2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="87" mass="9979" checksum="8CB9EFD382525633" modified="2019-05-08" version="1">MLMSVLNNARLIEKLSKTPPIRQAARLTVYLLSRLERGGREAAERLRERTDAPRRLDELSKKVAHLRDTWAKELKGAKEASGQKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD83</accession>
    <name>A0A401PD83_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000328">
        <property type="protein sequence ID" value="GCB71090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13759" checksum="6FE450842CEFE3F6" modified="2019-05-08" version="1">MSIIGNRQSETKKNPQYIGGNPIWRREQFHPQLLVSTVTDDPDIVTTRWPHVNIPATTSVSENDTNGATKLLVKITKRRQHNKERTLKRATQTEKEKIDEQQMEIAQAVFSNTGAHGAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDN6</accession>
    <name>A0A401PDN6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0001498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000340">
        <property type="protein sequence ID" value="GCB71234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PDN6"/>
    <dbReference type="OMA" id="NAWKHWI"/>
    <dbReference type="OrthoDB" id="10025028at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057926">
        <property type="entry name" value="QRICH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010507">
        <property type="entry name" value="Znf_MYM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051284">
        <property type="entry name" value="ZnF_MYMT-QRICH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736:SF6">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25561">
        <property type="entry name" value="QRICH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06467">
        <property type="entry name" value="zf-FCS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="462"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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        <location>
            <begin position="1401"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1433" mass="160084" checksum="C6090E298993EAB7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDT3</accession>
    <name>A0A401PDT3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAYSvFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0001508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000343">
        <property type="protein sequence ID" value="GCB71272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDT3"/>
    <dbReference type="STRING" id="75743.A0A401PDT3"/>
    <dbReference type="OMA" id="HSWSNER"/>
    <dbReference type="OrthoDB" id="71310at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039159">
        <property type="entry name" value="SAYSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019387">
        <property type="entry name" value="SAYSvFN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527:SF0">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10260">
        <property type="entry name" value="SAYSvFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SAYSvFN" evidence="3">
        <location>
            <begin position="90"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB71272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="19524" checksum="043B61E04020CAB8" modified="2019-05-08" version="1">MERKLAEWRARQRLEEPQSDGGFRQSRGVLADFWGRLRPRRVEAESREQPQDMTESRAKNENGQISFPERSLAEPVESDHSIFTTVNVLKFLLWLVLLGLFIELEFGLVYFVLSMFYWIYVGTRDPGRKKKGEVSAYSVFNPGCEAIEGSLTAEQFERELQYRPLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEF7</accession>
    <name>A0A401PEF7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">C-terminal PDZ ligand of neuronal nitric oxide synthase protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Nitric oxide synthase 1 adaptor protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0005965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001943">
        <property type="protein sequence ID" value="GCB71506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEF7"/>
    <dbReference type="STRING" id="75743.A0A401PEF7"/>
    <dbReference type="OMA" id="EWTWDAN"/>
    <dbReference type="OrthoDB" id="10030336at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050998">
        <property type="term" value="F:nitric-oxide synthase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01270">
        <property type="entry name" value="PTB_CAPON-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000124">
        <property type="entry name" value="carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF80">
        <property type="entry name" value="CARBOXYL-TERMINAL PDZ LIGAND OF NEURONAL NITRIC OXIDE SYNTHASE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB71506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="567" mass="63061" checksum="747EA969FE3263A3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFK9</accession>
    <name>A0A401PFK9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003545">
        <property type="protein sequence ID" value="GCB71884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFK9"/>
    <dbReference type="OMA" id="IMSVVKV"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB71884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="415" mass="41839" checksum="AD566C970FC1839F" modified="2019-05-08" version="1">MLTTNLVLAEAQPLGESLAPDEAQPLAAAQPLAEAQPPAEALAPDEAHPLAEALAPDEAQPLAAAQPLAEALGPDNAQSLAEALVPAEALAPADAQPFAEALVFAEALVIAEALAPDEAQPLAEALAPDEAQPLAAAQPLAEVLAPDEAQSLAEALVPAEALAPAEAQLLAEALFFAEALVIAEALAPAEAQPLAEALVFAEALVIGEALAPDEAQPLAEALVFAEAQPLAEALAPAEALVIAEAQPLAEVLVLAEALAPAEALVLAEAKALAETLVFAEALAPAEALVLAEAKALAEALVLAEAPVLSEALVLAEAQPPAEAQSLADALVLAEALVLAEAQLLAEALVLVEALVLAEALVLAEALVLVEALLLAEALVLAEALVLAETQPPAEAQPPAEAQPRGWFSTWLNSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGC9</accession>
    <name>A0A401PGC9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Allantoate amidinohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0001856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000432">
        <property type="protein sequence ID" value="GCB72171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGC9"/>
    <dbReference type="STRING" id="75743.A0A401PGC9"/>
    <dbReference type="OMA" id="MDDGWET"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000077">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="93"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="181"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB72171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="350" mass="39760" checksum="D7F9F0742AAB38B5" modified="2019-05-08" version="1">MAARPIQEKTGKLPDFVQLNDLACETTGAKILFATDDWFAVAENLLKRVAPQWKAEDFTNFGKWMDGWETRRKRIPDEVPDFPSRGEKMGTAASEQEVEAIRKLKSEFWTELVPMTILQPGYVDTCHNYLPAKQLKRWTHIRLNMYPDGGIARLRVYGIGHRDWSAVSQEQTIDLVAMTNGGVCLGYSDAHFGHPKNIIGIGRSNVMSDGWETARRLDRPPVLKADDQGILQVPGCEWAVFKLGHPGIIIHVEIDTSHFKGNFPDSCKIEGCAISPEEEKQRITMKWKESLRLKWELLLPITKLKPHQQHFYSIEMKDIVTHVRLTIKPDGGISRLRLLGHPCTLSSINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIG4</accession>
    <name>A0A401PIG4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000545">
        <property type="protein sequence ID" value="GCB72889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIG4"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB72889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="164" mass="18603" checksum="FAD142D4E7D14871" modified="2019-05-08" version="1">METCLQEKKAELQVVMNNLRDTKEQHLRTKISTLKQLDEKLKGQSGHDEVKKELSILKSMEGVATEGSGSQDTSKTLEVLLLEKNCSLQSENATLRITNSDFSDPVPALDLVHQLQLIVQQMQDIETENQKLRDTLEEYNKEFAEVKNQEATIKALKSMSMSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIY6</accession>
    <name>A0A401PIY6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0006616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002263">
        <property type="protein sequence ID" value="GCB73086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIY6"/>
    <dbReference type="STRING" id="75743.A0A401PIY6"/>
    <dbReference type="OMA" id="LVGTTYY"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF17">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="627"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB73086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="774" mass="84909" checksum="32D4012F71520FBD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKP6</accession>
    <name>A0A401PKP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">A-kinase anchor protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0002790</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000718">
        <property type="protein sequence ID" value="GCB73709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PKP6"/>
    <dbReference type="OrthoDB" id="28045at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071875">
        <property type="term" value="P:adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20878">
        <property type="entry name" value="C1_AKAP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000004">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000021">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
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        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 13"/>
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        <property type="entry name" value="AGAP007712-PA"/>
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        <property type="entry name" value="RhoGEF"/>
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        <property type="entry name" value="C1"/>
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        <property type="entry name" value="DBL homology domain (DH-domain)"/>
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        <property type="entry name" value="PH domain-like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_DAG_PE_1"/>
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        <property type="entry name" value="ZF_DAG_PE_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018974595" description="A-kinase anchor protein 13" evidence="10">
        <location>
            <begin position="16"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="1205"/>
            <end position="1252"/>
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    </feature>
    <feature type="domain" description="DH" evidence="12">
        <location>
            <begin position="1404"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="1641"/>
            <end position="1743"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="471"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="672"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="731"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="959"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1069"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1121"/>
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            <begin position="1176"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1742"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1880"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1961"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2084"/>
            <end position="2240"/>
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            <begin position="444"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="1121"/>
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            <begin position="1747"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50010"/>
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        <source>
            <dbReference type="PROSITE" id="PS50081"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="2244" mass="249684" checksum="D22727819D77E81A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PL55</accession>
    <name>A0A401PL55_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="5">3.4.24.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0002939</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Cleaves proteins, imported into the mitochondrion, to their mature size.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="5"/>
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        <property type="protein sequence ID" value="GCB73857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="17530at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial intermediate peptidase"/>
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    </dbReference>
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        <property type="entry name" value="Si:ch73-1a9.4"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="M3A_MIP"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Neurolysin/TOP_dom2"/>
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        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
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        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="19" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 21" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 21" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="22">
        <location>
            <begin position="240"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003435"/>
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        <source>
            <dbReference type="Pfam" id="PF01432"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB73857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="697" mass="79673" checksum="3D4C44F09F474EFE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPW1</accession>
    <name>A0A401PPW1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016269">
        <property type="protein sequence ID" value="GCB75135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPW1"/>
    <dbReference type="STRING" id="75743.A0A401PPW1"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7704" checksum="76ABC4352CB05F6F" modified="2019-05-08" version="1" fragment="single">MVAAGLYSNVRLLSSLLLTMSDNNPELFSPVQKYQLLVYHADSLFHDKEYRNAESKYKIALQQKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR63</accession>
    <name>A0A401PR63_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008667">
        <property type="protein sequence ID" value="GCB75587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR63"/>
    <dbReference type="OMA" id="SEWKYEF"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="13663" checksum="6827ED540CD93E7E" modified="2019-05-08" version="1">MVPTLETSECKYEFQKQSEWKYEFYKKPEWKYEFQKQSEWKYEFYKKPEWKYEFQKKSEWKYEFYKTSEWKYEFYKTSECKYEFYKTSEWVYEILGVSVEIGVPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSD1</accession>
    <name>A0A401PSD1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008739">
        <property type="protein sequence ID" value="GCB76049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSD1"/>
    <dbReference type="STRING" id="75743.A0A401PSD1"/>
    <dbReference type="OMA" id="KNCWEES"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01251">
        <property type="entry name" value="PH2_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000099">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037851">
        <property type="entry name" value="PH2_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF1">
        <property type="entry name" value="ARFGAP WITH DUAL PH DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="181"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="368" mass="42738" checksum="4D65D80D068E4AEB" modified="2019-05-08" version="1" fragment="single">YMSQHGNEAAKEKYEAYVPAYYYIPTYTDCQVLQEQWIRSKYERKDFSEANKPLAYATGYREGFLWKRGRDNGQFLNRKFVLSESDGILKYFAKNDAKEPKAVIKVDNINATFQPTKIGNPNGLQITYLKDNSTRNIFVYHEEGKEIVDWFNAIRAVQFHYLQVAFPGASDDELKHKLTRNFLKEGYMEKTGPKQTEGFKKRWFTLDHRRLMYYKDPLDAFAKGEVFIGSSDNKYLVREGLPPGVQGNANWQYGITIVTPDREFLFTCETESDRKEWMSVFNGVMNQQMSPQEFTSRFLTHFPPHSLSPHSIQLGLAMKVFGAFEDPHCIFATLVVFCQWQKNRKIPRTLQPSVINLHISDPGLLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSK2</accession>
    <name>A0A401PSK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010012">
        <property type="protein sequence ID" value="GCB76073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSK2"/>
    <dbReference type="OrthoDB" id="9948000at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019540165" evidence="1">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="161" mass="18145" checksum="B2D437D05D964354" modified="2019-05-08" version="1">MDHKLQTVFALIALISILIPDLTEGTETCQGLFDNDNYLNFTSRLKEIANCSDDHVRSLEAEKQGELLQLLTNAAEQLKSTRMKACRDVHPKNCSFPLIPRNGGLICLTHEKTRYCKPMCNQVGTHSVTHSTALFTFTFPHPHQLSAPGESFSDARYQRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT41</accession>
    <name>A0A401PT41_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0018327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012653">
        <property type="protein sequence ID" value="GCB76316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT41"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB76316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="237" mass="21933" checksum="54DC1B4DB21814E8" modified="2019-05-08" version="1">MRAPANHLLEITIQKYFMNDDCSLNYIALYDSLVPGKKKLIIRICSSSQPFPLQTFTVTSSGNVMLAIFFSQSQHMNHAAGVPAASGVAATAGVPAAADVAAGGGVAAGIATAADGPDVVAGVAAAGGAADVVASFPAATVIAAAGFPAAAGGGADVAAGVAATAGVVATAGVVAAGVAATSGVVAAADVAAGVAAAAGVAASAVAVVVADGAIVAAVATGVAAGVAVAAVVAVAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU80</accession>
    <name>A0A401PU80_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016626">
        <property type="protein sequence ID" value="GCB76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU80"/>
    <dbReference type="STRING" id="75743.A0A401PU80"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019376274" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18812" checksum="A9DF96EF1B4AC585" modified="2019-05-08" version="1" fragment="single">MELIWLVLLVLVLYFGLFHRGSGGWTKPEVREKGTADGSLRYGFTDIPAMRLSGLSLNVTAHLSNTIFGQLILVPLIMSVTEERPGFNFKSISDFLEGYKSGKITPTQVAKNIISALEDADQAVMPLRAIVQYEGDQIIKMAEASTARYRANAPLSPLDGIPVCLKEEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY44</accession>
    <name>A0A401PY44_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutS connector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016970">
        <property type="protein sequence ID" value="GCB78055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY44"/>
    <dbReference type="STRING" id="75743.A0A401PY44"/>
    <dbReference type="OMA" id="ENTMIIG"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000003">
        <property type="entry name" value="mutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS connector" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="172" mass="19320" checksum="131D7791C409C7DD" modified="2019-05-08" version="1" fragment="single">LARGEIGMASIDMKSPELILSQFADNTTYAKVITKLQILTPLEIIMPNTTCDKGSGTKLFTLITDNFKSVALSTVQRKYFNETKGLEYIEQLCTPEFSTVLMEIQMKYYCLAAAAALLKYVEFIQNTVYAPKSLKVIFKGSEQTAMIDSASAQQLELIINNRDPRYTDKHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYN7</accession>
    <name>A0A401PYN7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010402">
        <property type="protein sequence ID" value="GCB78200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYN7"/>
    <dbReference type="OMA" id="APGMGRM"/>
    <dbReference type="OrthoDB" id="10448098at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7082" checksum="4603B3FF0D372097" modified="2019-05-08" version="1">MEATVGRLVLEALKTSNGVPSGNRLHVVFSRCILREELCSSNRDSSLSLPRAPGDGAHAPAALLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYQ3</accession>
    <name>A0A401PYQ3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014375">
        <property type="protein sequence ID" value="GCB78274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYQ3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="52" mass="5655" checksum="76558C26FE460593" modified="2019-05-08" version="1" fragment="single">PECGMCTVQFGSKHLSRGTSLQARVTIQSHSWLDTAADERLGGQEVHHSSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYW9</accession>
    <name>A0A401PYW9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0020662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017039">
        <property type="protein sequence ID" value="GCB78334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYW9"/>
    <dbReference type="STRING" id="75743.A0A401PYW9"/>
    <dbReference type="OMA" id="EMPHEMS"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000089">
        <property type="entry name" value="Putative global transcription activator SNF2L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="7">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="6">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB78334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57693" checksum="24C334CD4F5D2F56" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYZ1</accession>
    <name>A0A401PYZ1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018326">
        <property type="protein sequence ID" value="GCB78300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYZ1"/>
    <dbReference type="STRING" id="75743.A0A401PYZ1"/>
    <dbReference type="OMA" id="YQFAINE"/>
    <dbReference type="OrthoDB" id="45963at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028260">
        <property type="entry name" value="FAM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206:SF9">
        <property type="entry name" value="PROTEIN FAM177B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14774">
        <property type="entry name" value="FAM177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="153" mass="17680" checksum="1192BDA5A4A94EB6" modified="2019-05-08" version="1" fragment="single">VAFCVSLEDDQDLEAATQTEAAEPKDTEAGKKEPKRRIHFSSGETMEEYSTEEEFEEEQKVLETVNPSTLPWSHFLLFWMMKFARTSLFTCDFLGEKLANLFGLTSAKYQYAVDEYYSVQDQVTYNYQINSAFYYISFVKQGGIIRFIMGCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ51</accession>
    <name>A0A401PZ51_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017063">
        <property type="protein sequence ID" value="GCB78437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ51"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="8165" checksum="57CBD0D4336983E2" modified="2019-05-08" version="1" fragment="single">ESFCDYLHFGPGARSHCHHSGCRNDLLTEAFDYCPQPTHWCPRLWKKLPLDTLRLNLHRSCHLIPCYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ80</accession>
    <name>A0A401PZ80_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase F(1) complex subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP synthase F1 subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0015816</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Component of a complex composed at least by ATPIF1, ATP5F1A, ATP5F1B, ATP5F1C AND ATP5F1E.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009148">
        <property type="protein sequence ID" value="GCB78343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ80"/>
    <dbReference type="STRING" id="75743.A0A401PZ80"/>
    <dbReference type="OMA" id="PHQTIYR"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.440:FF:000002">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048937">
        <property type="entry name" value="ATPD_C_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21335">
        <property type="entry name" value="ATPD_C_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="18">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase delta subunit C-terminal" evidence="19">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB78343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="13764" checksum="5D899C7CD67D1E2A" modified="2019-05-08" version="1">MSFTFASPTEVYCTEANVKQIDVPTMTGNVGILPVHVPTLQVLQPGIITVFDEEGAQSKYFVSSGSVTVNADSSVQLLAEEAAALDELDITAAKTNLGKANAELSSASGEIERAEVLVSIEAHEAIIKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ94</accession>
    <name>A0A401PZ94_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Interferon-induced protein with tetratricopeptide repeats 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0021203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the IFIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018361">
        <property type="protein sequence ID" value="GCB78441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ94"/>
    <dbReference type="STRING" id="75743.A0A401PZ94"/>
    <dbReference type="OMA" id="YERAKTC"/>
    <dbReference type="OrthoDB" id="10043504at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000036">
        <property type="entry name" value="interferon-induced protein with tetratricopeptide repeats 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10271">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10271:SF0">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB78441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="53417" checksum="D206DFE383F2F8F0" modified="2019-05-08" version="1">MSNTQDLLKVELDQLQCHFTWAPQRENIDLDDMKQRLQDSIDLKMKYQTRSYNQLAFVNCLQGKCEEAIQNLSTAETILRENHEDEFDKRIIITYGNYAWVYYHKGQLTKAQSYLDKLERICQQFPDASRYTAMIPEVYGEKGWSLLNSGVQQYKEAMECFETALEQDPSNTDWIVGYAIVLSRLEQLSGVTESVDSSHSVKQWRRVLKLDPNDAEAMVQLALKLRVFEQYEEADTLVKQALEKSPGVPYVLRYAAKFYRCAGNIEKALKLLDKALKMSPNSAFLHHQKGACYQNKIKTLKKTRGSIDSGKIDKLINDCKDCFTKAFELKPSFIIAKLNYAHVCSINGEYREAEKIYNELLELENTCPENKQDIRFEVGLFEQNYKHSKSNAIKYLLEGFKIKYDSKSRNNCRTHLEKIAENPQQDIVAFCIRGIIHMLDGEECFEKILEIERGKIVTCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q096</accession>
    <name>A0A401Q096_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM177A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009217">
        <property type="protein sequence ID" value="GCB78713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q096"/>
    <dbReference type="STRING" id="75743.A0A401Q096"/>
    <dbReference type="OMA" id="NFESVEM"/>
    <dbReference type="OrthoDB" id="45963at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028260">
        <property type="entry name" value="FAM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206:SF5">
        <property type="entry name" value="PROTEIN FAM177A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14774">
        <property type="entry name" value="FAM177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21001" checksum="C0ACE491C2ECE0EC" modified="2019-05-08" version="1">MLQANGKSFENVELGDASTKKQKPPRRIIHFASGETMEEYSTDEEEQEDEKKDLLPMIDTSKLPWGPFLWFYMLRFATGTLSVCDFLGEKLASLFGINAPKYQYAIDEYYRIKKEEEEEEEENKMSEEAEKNYQEQMGLQQDVVSAHDGLPVVNASFVNVSFEMESDPTTITETKQRGDSIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0Y2</accession>
    <name>A0A401Q0Y2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011919">
        <property type="protein sequence ID" value="GCB79079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0Y2"/>
    <dbReference type="OMA" id="GQSCGRD"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="185" mass="21232" checksum="BDDA2431305685E8" modified="2019-05-08" version="1">MGQRWDRAAAEMGQSCGRDGTELRQNCGRDGTELRQRWDRAATEMGQSCGRDAAEMGQSYDRGGTELWQRCGRDGTELRQRWDRAVTELRQRWDTVAAEIGQSCDRAAAEMGERCGRAAAEMGQICGRGGTELQQSCDRAVMEMRRRWNKAVRSYVANYYVKLPQRWDRSATELRRRCDEDTTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1L7</accession>
    <name>A0A401Q1L7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018564">
        <property type="protein sequence ID" value="GCB79244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1L7"/>
    <dbReference type="STRING" id="75743.A0A401Q1L7"/>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0518">Myosin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="48" mass="5628" checksum="5E463A62EC9E7B95" modified="2019-05-08" version="1" fragment="single">HAMDILGFVTEEKHNCYKMVGVIMHFGNMKFKRKIREEQAEIDGTESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2I3</accession>
    <name>A0A401Q2I3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial nucleoid factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitochondrial protein M19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013403">
        <property type="protein sequence ID" value="GCB79639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2I3"/>
    <dbReference type="STRING" id="75743.A0A401Q2I3"/>
    <dbReference type="OMA" id="HEYPRPR"/>
    <dbReference type="OrthoDB" id="6266314at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037698">
        <property type="entry name" value="UQCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34260">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34260:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB79639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="122" mass="13803" checksum="C3B8B7EC841EDC78" modified="2019-05-08" version="1">MLLRLPVLRSRKAASLALSFGSKWCKVSGKGESIRIINPEKCDLAYGSLTRIHTAYYKNKSPHLRITGFTGVTVEECQMVLATSNMKQMEETKKGLWKKLREKFTGKPEDVTKEYDLTVTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2W2</accession>
    <name>A0A401Q2W2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016080">
        <property type="protein sequence ID" value="GCB79759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2W2"/>
    <dbReference type="STRING" id="75743.A0A401Q2W2"/>
    <dbReference type="OMA" id="HEMHIVH"/>
    <dbReference type="OrthoDB" id="535509at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF6">
        <property type="entry name" value="RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="152" mass="17297" checksum="B6CA9B56E3E48EB1" modified="2019-05-08" version="1">MSLDDIRIDSNELIEKQPMDGGGFGMVSLCCTRKHGLVVLKTVYTGPQRTEYNTSLLEEGKMMHQLDHDRVIKLIGVILEDGNYSLVMQFMENGNLLQLLHSVIIPLSVKGRIILEVIEGMTYLHEMHIVHKDLKPENILVDKDYHIKVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q382</accession>
    <name>A0A401Q382_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0017957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012088">
        <property type="protein sequence ID" value="GCB79800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q382"/>
    <dbReference type="OrthoDB" id="6356248at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF9">
        <property type="entry name" value="XK-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB79800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="61" mass="7425" checksum="C350EA3692BB801D" modified="2019-05-08" version="1" fragment="single">MYLGIQSRRKNEHQRRFYWAMMYEYADVNMLRLLETFLESAPQLVLQLCIMIQKNQAETLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4U9</accession>
    <name>A0A401Q4U9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009637">
        <property type="protein sequence ID" value="GCB80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4U9"/>
    <dbReference type="STRING" id="75743.A0A401Q4U9"/>
    <dbReference type="OMA" id="MFELVTH"/>
    <dbReference type="OrthoDB" id="3908708at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16406" checksum="15B5A88949132FB5" modified="2019-05-08" version="1">MFELVTHQTKVHLASWSSSSDTTFKSTESFGVRQPARNKIKRHNRSLATVFRGRSFKDEKSDNEEGRDAATDDPTELSTQVTAPGVLKIFGDEICAGANYKSVLATPCSSALELVKEALERLVLAVPSILGFGIQHKTWQKITLGRKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5Y6</accession>
    <name>A0A401Q5Y6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027489">
        <property type="protein sequence ID" value="GCB80768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5Y6"/>
    <dbReference type="STRING" id="75743.A0A401Q5Y6"/>
    <dbReference type="OMA" id="DINACHI"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF2">
        <property type="entry name" value="AMP DEAMINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="11769" checksum="1A23EFF710C4B875" modified="2019-05-08" version="1" fragment="single">GRQTFHRFDKFNAKYNPVGASELRDLYLKTDNYMQGEYFARIIKEVSRDLEESKYQYTEPRLSVYGGSPNEWANLARWFIKQQVYSPNVRWVIQVPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q678</accession>
    <name>A0A401Q678_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0022721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01023737">
        <property type="protein sequence ID" value="GCB80873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q678"/>
    <dbReference type="STRING" id="75743.A0A401Q678"/>
    <dbReference type="OMA" id="PKMERIG"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF45">
        <property type="entry name" value="PLASMA ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB80873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="148" mass="17081" checksum="B09C7391C048CFAC" modified="2019-05-08" version="1">MHWPVWNVLAGLSVSPPSWQSIDSRPLPPWYDQAKFGIFIHWGVFSVPSFGSEWFWYYWQKEKLKPYVEFMERNYPPGFTYADFAPMFSASFFDAAEWADVLSASGAKYIVLTSKHHEGNGLFNTPALDPLPKWSNPPKMERIGSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q687</accession>
    <name>A0A401Q687_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022440">
        <property type="protein sequence ID" value="GCB80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q687"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10099" checksum="142095DC3BADB390" modified="2019-05-08" version="1" fragment="single">KKLKSTSKYIYQTLFLAGENSDITICALGQEWHLHKIYLCQSGYFSSMFSGSWKESNMSCIELEIPDQNIDTEGTFPLAFSLRGRTVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q722</accession>
    <name>A0A401Q722_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0021336</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018718">
        <property type="protein sequence ID" value="GCB81127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q722"/>
    <dbReference type="STRING" id="75743.A0A401Q722"/>
    <dbReference type="OMA" id="MENGNCE"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004957">
        <property type="term" value="F:prostaglandin E receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071380">
        <property type="term" value="P:cellular response to prostaglandin E stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000370">
        <property type="entry name" value="Prostglndn_IP_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF8">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00856">
        <property type="entry name" value="PRSTNOIDIPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB81127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="325" mass="35559" checksum="2C5A92CD13596ABC" modified="2019-05-08" version="1">MIGKDSLGMENGNCEKSANITVGAEPAVSAAMFATGVVGNVLALVVLAAHRRDSRNKASLFHILVSGLIVCDLLGTVLISPMVLAAYSTGRSLRDLGLCRCCAFAMAFFGLTSMLILLAMALERCLSIGCPYLYRRHASKRCGLLAIPAFCAFSGLFCCLPLLGIGQVAQYCPGTWCFIRMWGRPLSLQHRVYSLSYAVLLKLLIVSTLLCNVSVIVNLCRMYQKQRTRRCSRSVHPGGGDRRPPPAEEVDHLILLAIVTVTFVACSVPLTVRAYIGAIYEEQSHNHYADLQALRCLSFNPIIDPWVFIILNTSKVKKTLSRILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q827</accession>
    <name>A0A401Q827_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 151B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0023001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025468">
        <property type="protein sequence ID" value="GCB81522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q827"/>
    <dbReference type="STRING" id="75743.A0A401Q827"/>
    <dbReference type="OMA" id="ESMIYHE"/>
    <dbReference type="OrthoDB" id="190434at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14857">
        <property type="entry name" value="TMEM151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="52138" checksum="7FAC5C2C18C9FC55" modified="2019-05-08" version="1" fragment="single">QRPLKQSLSGSLCRDSHWKCLVLTLLMYGCFGVVTWCHLSKVTRLAFNKPYGGESMIYHESPCSSGYVYIPLAFLMMLYVVYLVECWHCYTKNEMQHKVDVNSVYERMQRLQQATPCIWWKAISYHYIRRTRQVTRYRNGDAYTTTQVYHERVNTHLSESEFDYSQHGARDISKELLGLSEYTATKLRFTKCFSFANAESETSYLTQRARFFSENEGLDDYMEAREGMHLKNVDFKEHMVAFSDPKNPPWYVSRYIFWTLSFLVLSWPLRVLAEYRTAYVHYHVEKLFGLDEGLLLTPEEGGPYGRRISRVNTIDMTELEWHIRSNQQLVPSYSEAMLMEVSSSSTAAATYLQQCQRCRRTVSSSSLPSREPAARLPFSRSRFSLGRLQGSGRAYLFRSLSGRFGGGGGLSAEEPPSYQDAIYFPRLIVHAGSGCRGHRPRQQDGTGPDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8R4</accession>
    <name>A0A401Q8R4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020389">
        <property type="protein sequence ID" value="GCB81764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8R4"/>
    <dbReference type="STRING" id="75743.A0A401Q8R4"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15440" checksum="8B76914E5EED77E1" modified="2019-05-08" version="1" fragment="single">MQSATRSKLFEFLAHGLRPGMPPGSRMPPQGASMGPPGPSYGGSPAVRPGMPQSMMDQSRKRPAPQQIQQVQQQAAQNRNHNAKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC32</accession>
    <name>A0A401QC32_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01031345">
        <property type="protein sequence ID" value="GCB82916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC32"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="51" mass="5778" checksum="5145C3F32F37DBEB" modified="2019-05-08" version="1" fragment="single">TQVQRIKSFVLAINDLTSDRTAAENRSQTLVIRDLSKKLTEAISMEKSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCF8</accession>
    <name>A0A401QCF8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01028947">
        <property type="protein sequence ID" value="GCB83036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCF8"/>
    <dbReference type="STRING" id="75743.A0A401QCF8"/>
    <dbReference type="OMA" id="CTVTYSH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="222" mass="25233" checksum="8CE5DE6EBFE9F11B" modified="2019-05-08" version="1">MAVQSNLDPEPRLCSLNRSLRPRLCSLTWSLRPRLCSLTRSLRPRLCSLTWSLRPRLCSLTWSLRPRLCSLNWSLRPRLCSLNWSLRPRLLQSNLEPEAQTVQSNLEPLAQAVQPKLEPEAMAVQSNLEPEAQALQSNPKPEAQAVMPNLEPEPIAVQSKLEPEAQPVQLNLDPEAQTMQFNLKPEAQAVQFNMEPEPLAVQSNLSLRPRLCSLTWSLRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCW6</accession>
    <name>A0A401QCW6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029290">
        <property type="protein sequence ID" value="GCB83214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCW6"/>
    <dbReference type="STRING" id="75743.A0A401QCW6"/>
    <dbReference type="OrthoDB" id="5987641at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008088">
        <property type="term" value="P:axo-dendritic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="196" mass="21866" checksum="4B1363B3664825CF" modified="2019-05-08" version="1" fragment="single">SWKARLGAIYNQTKVPSAEGFLQRSPWYHRVSCLNSNDASCQLRFHKSPVVLHDDAAKSFGQKEDLNSRANKLGGMVQLQGLKESMSIEIVSVSEFSVLFTLVAPDFGAATVVFWDLETQEVKYHHIDSHSLPVEGDGKDELCLFLTDAGLSMVVFAFSQEDLLNRLMIYGKAGIVDSVCHLNHWNRCSIPIHALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE42</accession>
    <name>A0A401QE42_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0024490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01048198">
        <property type="protein sequence ID" value="GCB83678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE42"/>
    <dbReference type="STRING" id="75743.A0A401QE42"/>
    <dbReference type="OrthoDB" id="10254995at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF16">
        <property type="entry name" value="MYOSIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB83678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="128" mass="14842" checksum="66B8B8B07C5B809A" modified="2019-05-08" version="1" fragment="single">RLRREEKQRQELEKNRRKLEGDSSDLHDQIAELQQQIAELKAQLAKKEEELQAALARTDEEGAQKIIALKKIRELESHISELQEDLESEKVARTKADKQKRDLGEELEALKTELEDTLDSTAAQQELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE47</accession>
    <name>A0A401QE47_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinesin-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01040299">
        <property type="protein sequence ID" value="GCB83634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE47"/>
    <dbReference type="STRING" id="75743.A0A401QE47"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-associated" evidence="1">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="31" mass="3892" checksum="EA200EE06875A3C8" modified="2019-05-08" version="1" fragment="single">MDRLQETEKIIEELNETWEEKLRKTEAIRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEJ4</accession>
    <name>A0A401QEJ4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01047232">
        <property type="protein sequence ID" value="GCB83791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEJ4"/>
    <dbReference type="STRING" id="75743.A0A401QEJ4"/>
    <dbReference type="OrthoDB" id="9274484at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="86" mass="9662" checksum="12CC337A13D38FB1" modified="2019-05-08" version="1" fragment="single">VLDEEFEGIFQETSPQQTMSVRGAILSQESADSMVTYTQGLFYQYSCNYPLLYLISDTQISVDGLSVAMRDNQGRFISTLGLELYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEK8</accession>
    <name>A0A401QEK8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0024380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01044784">
        <property type="protein sequence ID" value="GCB83829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEK8"/>
    <dbReference type="STRING" id="75743.A0A401QEK8"/>
    <dbReference type="OrthoDB" id="9944769at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB83829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="100" mass="11385" checksum="5D7093F921C4E4C3" modified="2019-05-08" version="1" fragment="single">KKTEARKRKTGNKMAGDAGECLRNETTEMVVESLHVVHTDFSTDALQKTVRFDLKHSFLVTGGVDGFIRVWEFPSMKKRFDFRAHDGEVEDVDISPDNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEY6</accession>
    <name>A0A401QEY6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0024565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01050029">
        <property type="protein sequence ID" value="GCB83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEY6"/>
    <dbReference type="STRING" id="75743.A0A401QEY6"/>
    <dbReference type="OrthoDB" id="10263264at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018985447" description="SP-RING-type domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="11606" checksum="79E64E685CC4D5AD" modified="2019-05-08" version="1">MLSVLSVFGLRSHFLVVVTVKEKLTADPDSEIATTSLRVSLICPLGKMRLSVPCRAMTCTHLQCFDATLYLQMNEKKATWVCPVCDKKAPYENLIIDGYGMSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFB9</accession>
    <name>A0A401QFB9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01050447">
        <property type="protein sequence ID" value="GCB84053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFB9"/>
    <dbReference type="STRING" id="75743.A0A401QFB9"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10243" checksum="89E18F505B3CC659" modified="2019-05-08" version="1">MSNQHGQLPLGNVQPMCELQQVRQGHHWGVTAGRAPTSDHQRGNHSDRVLSDMTILQRRIPLSFREPGTAPLRKLSVDLIKTYKHINEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFQ7</accession>
    <name>A0A401QFQ7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01053555">
        <property type="protein sequence ID" value="GCB84193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFQ7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="93" mass="10935" checksum="20466A60016EDAF7" modified="2019-05-08" version="1" fragment="single">YRTCWTRVQKNSGYFIPNVLQYGDDATFGCCLFYTGLEKFATGDYHSKLPLPDLLLVDPRVSQVDAISEEKHRSHECYTENGKNEWEIFFKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHY3</accession>
    <name>A0A401QHY3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01110057">
        <property type="protein sequence ID" value="GCB84952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHY3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="34" mass="3932" checksum="072CECCB812AA310" modified="2019-05-08" version="1" fragment="single">MYTGELYELYAGELYGGELYTGERYAGELYTNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI82</accession>
    <name>A0A401QI82_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0025796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
        <text evidence="3">Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01128305">
        <property type="protein sequence ID" value="GCB85094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI82"/>
    <dbReference type="STRING" id="75743.A0A401QI82"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB85094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8878" checksum="6A03AF2CC7D39082" modified="2019-05-08" version="1" fragment="single">MVKHIRSLDSDMQTLVYENYNKFISATDTIRKMKNDFKKMEDEMDCLATNMAAITEFSARISNTLQDQHQQITKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJJ4</accession>
    <name>A0A401QJJ4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01175074">
        <property type="protein sequence ID" value="GCB85533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJJ4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="59" mass="7141" checksum="657E40BFDEC3D388" modified="2019-05-08" version="1" fragment="single">MRQSVFTPAHWLMEQWVEYLDETFARYRKECTEDVTQMIASIKEVVDRVEEKMTIQGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJT6</accession>
    <name>A0A401QJT6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="GCB85661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="PHVWPCL"/>
    <dbReference type="OrthoDB" id="10443013at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="9894" checksum="EDBAEE835609D5BA" modified="2019-05-08" version="1" fragment="single">EAPAEGIISAGLHERVNDDPDGDLAAGHWSIGTRARNLGNRAGDIGHSHPDEHPHVWPCLIHRDLPDLEVPTSDIRGSMTCDPTWPSQGGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKN5</accession>
    <name>A0A401QKN5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
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        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01209583">
        <property type="protein sequence ID" value="GCB85914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="NCDTRDY"/>
    <dbReference type="OrthoDB" id="6162112at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34839">
        <property type="entry name" value="CS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34839:SF1">
        <property type="entry name" value="MYOSIN-9-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="333" mass="37795" checksum="6AB4C87D8984B26D" modified="2019-05-08" version="1" fragment="single">KTTLDNTIFKTTLDTTIFKTTLDNTFIKTTLDNTIFKTTLDTTIIKTTLDTTIFKTTLDNTIIKTTQDITIFKTTLDNTIIKTTLDITIFKSTLDTTIFKTTLDNTVFKTTLENTVFKITLDTTIIKTTLDNTIFKTTLDNTVFKTTLDNTVFKTTLDTTIFKTTQDITVFKTTLDNTIIKTTLDTTIFKTTLDNTVFKTTLDNTIIKTTLDITVFKSTLDTTIFKTTLDNTVFKTTQDITIFKTTLDNTIIKTTLDTIIFKTTLDNTVFKTTLDNTVFKTTLDITIFKTTLDNTVFKTTLDTTIFKTTLDNTVFKTTLDNTIFKTTLDNTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKN8</accession>
    <name>A0A401QKN8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
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                <person name="Murakumo K"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01219695">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKN8"/>
    <dbReference type="OrthoDB" id="10004365at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="13468" checksum="00CB31E5E1CD0EA2" modified="2019-05-08" version="1">MYRGEVMYRGEVMYRGVAVYQDEVMYHGEVMYHGVAVYQGKVMYHGVAVYQGEKVYRNDAVYRGEVMYRGEAVFQGEEVYRGEAVYQGEEVYRGEAMYQGEEVYQGEEVWCCSVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMB0</accession>
    <name>A0A401QMB0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Carcharhiniformes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01302930">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="HHRYILV"/>
    <dbReference type="OrthoDB" id="10236072at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="280" mass="30935" checksum="EB1E0812D1B08F32" modified="2019-05-08" version="1" fragment="single">SDAGQQYSDAGLQYAYAGRQYSDAGLQYSDAELQYSDTEPQYSDVVPQYSDAGRQDTDAVRHYSDTGLQYSDTGLQYSDMGLQYSDTGLQYSDTGLQYSDSERHYSDAGRQYSDSGLQYSDTGQQYSDAGQQYSDAGLQYAYAGRQYSDAGLQYSDAGLQYSDAELQYSDAELQYSDAELQYSDAGLLYSDAELQSSDAGLQYSDTGLQYSYTELQYSDAGLQYSDTELQYSDAGLLHSDTALQYSDAGLQYSDAELQYSNAGRQYSDAALQYSDAELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMP7</accession>
    <name>A0A401QMP7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
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        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01322070">
        <property type="protein sequence ID" value="GCB86660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMP7"/>
    <dbReference type="Proteomes" id="UP000288216">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="50" mass="5441" checksum="8E63723C47348327" modified="2019-05-08" version="1" fragment="single">YAGELYAGELYAGEQHAGELYTGEQYAGELNVGELYTGELYAGELYTAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QN71</accession>
    <name>A0A401QN71_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01355979">
        <property type="protein sequence ID" value="GCB86834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QN71"/>
    <dbReference type="STRING" id="75743.A0A401QN71"/>
    <dbReference type="OMA" id="SQGEQRC"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="13949" checksum="CB6A1053C085AE0F" modified="2019-05-08" version="1" fragment="single">MSNAAERAASQSEQRRRASSAAERAASQSEQRRRASSAAERAIPQSEQRHRASSVRERAASQSEQRRRASNTAERAASQGEQRCRASSVAERAIPQVEQRHRASSVTERAAPQSEQRHRAGSVTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNC0</accession>
    <name>A0A401QNC0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01376469">
        <property type="protein sequence ID" value="GCB86919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNC0"/>
    <dbReference type="OMA" id="DVPRYPA"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="174" mass="19432" checksum="54E63281C274F002" modified="2019-05-08" version="1" fragment="single">TVLLDGQSCPGWCPILYCWMDGAVLAGVQYRTAGWTELSWVVSNTVPQDGQSCPGWCPIPYCWMDGAVLVGIQYRTAEWTELLSWLVSNTVLLDGQSCPGWCPIPYCWMDRADVLAGVYYRAAGWTELSWLVSNTVLLDGRSCPGWCPIPYCWMDRAAVLADVQYRTAGWTELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNX7</accession>
    <name>A0A401QNX7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01398818">
        <property type="protein sequence ID" value="GCB87066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNX7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="19194" checksum="C58B731B9311BE62" modified="2019-05-08" version="1" fragment="single">LVTDNRNGAGYRHREWSWLQTDTGNGAGYRHREWSWLQTLGMELVTDTGNGAGYRHREMSWLQTDTRNAAGYRQTPGIGAGYRREEWSWIQTPGMELVTDTWNGAGYRQTPGMQLVTDRHQEWSWLLTPVMELDTDTGNGAGDRETPGMQLVTDTGNGAGYRHQEWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPA8</accession>
    <name>A0A401QPA8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01423729">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPA8"/>
    <dbReference type="STRING" id="75743.A0A401QPA8"/>
    <dbReference type="OMA" id="ICPAHRE"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="186" mass="22228" checksum="22251E1644EE212E" modified="2019-05-08" version="1" fragment="single">SEIRLDSEIRLDSEIRLDSEIRLDGEIRQDSEIRLDSEIRLDGEIRQDRVIGQHSEIRLDSEIRLDSEIRLDGEIRLDSEIRLDSEIRLDGEIRLDSEIRLDSEIRLDSVIRQDSEIRLDSEIRWDSEIRLESEIRRDSEVRADSEIRLDREIRLEDEIRLDGEIRRDSEIRLESEIRRDSVIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPQ5</accession>
    <name>A0A401QPQ5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0028045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01457215">
        <property type="protein sequence ID" value="GCB87308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPQ5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10530" checksum="E1CB95D0B862B142" modified="2019-05-08" version="1" fragment="single">MNTKQRSPEVPPANTIQRSHEVPQANTKQRSPEVPEANTKKRSPEVPQANSNQRSPEVPDVNTKQRSPEVPEADTKQRSPEVPEANTKQRSPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NFV0</accession>
    <name>A0A401NFV0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Metal transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0012607</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Metal transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ACDP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006130">
        <property type="protein sequence ID" value="GCB59819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NFV0"/>
    <dbReference type="STRING" id="75743.A0A401NFV0"/>
    <dbReference type="OMA" id="TWTRIAF"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905941">
        <property type="term" value="P:positive regulation of gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032026">
        <property type="term" value="P:response to magnesium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057492">
        <property type="entry name" value="Ig_CNNM1/2/4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF22">
        <property type="entry name" value="METAL TRANSPORTER CNNM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25511">
        <property type="entry name" value="Ig_CNNM4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019098705" description="Metal transporter" evidence="13">
        <location>
            <begin position="34"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="14">
        <location>
            <begin position="177"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB59819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="505" mass="55961" checksum="D3EF01A6A140EEDA" modified="2019-05-08" version="1">MAACSSGRLGVFTLSAFSACCFFLSLCPRPVGAAADEGDTVIIGLRLEDTDEVTGMEEGVLRVSERTRVRLRLYGQRIDNSTWSRIGFTEYRRPGAGFDPCGVRTSDIVVLPGVAAGRPGSGVIEVEVKPLRKTEKRKAYYLCTAARAPEPGSGGQADWLYHDTKDTMVLVVEERKSMMPFWLQVIFISVLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGVVAVAVSTLGIVIFGEIVPQAICSRHGLAVGANTIVLTKFFMLLTCPASYPVSRLLDVILGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITSDATLDFNTMSEIMESGYTRIPVCEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGGIMLICFFPLSCWSCRSNSLAYVDSFQMILYCLPILPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHW0</accession>
    <name>A0A401NHW0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0009176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003677">
        <property type="protein sequence ID" value="GCB60454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHW0"/>
    <dbReference type="STRING" id="75743.A0A401NHW0"/>
    <dbReference type="OMA" id="CECINGG"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018941">
        <property type="entry name" value="Tyr_kin_Tie2_Ig-like_dom-1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10430">
        <property type="entry name" value="Ig_Tie2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019218167" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="345"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB60454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="48226" checksum="C6647A46FFCFF08E" modified="2019-05-08" version="1" fragment="single">MDLLGILIIHLYCLSNSGLIEALLDLTLINPSPLISTSETSLVCVPNGKPVPDQISITRAVDAFVDRPRILAEQSRTKNYSSKVVWKNNEQNDSVGIFICEGKFNDEVTTITTVKMSQQAHFFPEVFSITANKGENVTIQFKRQLQTDADVMIYKNGGFISSVPRDDVAHMVEYPFKSVTVDDAGVYSAFLIGGNVLTAAFTRLIVRKCEANVWGPECSKLCPGCLNGGVCHDQTGNCICPPGFMGQRCETACGQSTYGRSCRICKGGNCRFSMFCLPDPYGCSCATGWRGLQCDKACDPGFYGPDCRLKCECINGGKCDRFRGCLCPQQWQGQHCEKEGLGELPLQLVNPSDNIEVNTGMNLRLNCTATGQPMPVHGDIQLLIPHRGEVNPERTITHPVNQTITFFKVLKMSPSDSGEWICHVKTAVGVAVRPFNVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI69</accession>
    <name>A0A401NI69_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0006886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002406">
        <property type="protein sequence ID" value="GCB60571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI69"/>
    <dbReference type="STRING" id="75743.A0A401NI69"/>
    <dbReference type="OMA" id="DSHLCKM"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB60571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="109" mass="12051" checksum="5B02A821D16FAD01" modified="2019-05-08" version="1">MFLEWKSLSDSHLCKMCPQNEVSLLKNEVAQLKQLLLTHKDCPITTLQEESQSYLSPENSQPGSPIPACSQQQVIQHNSISTSTAVNEVVGSSTLTQLSNQRTDLNPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIC4</accession>
    <name>A0A401NIC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type-III domain-containing protein 3A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FNDC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004990">
        <property type="protein sequence ID" value="GCB60632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIC4"/>
    <dbReference type="STRING" id="75743.A0A401NIC4"/>
    <dbReference type="OMA" id="GETEAMC"/>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000175">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000180">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000185">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000309">
        <property type="entry name" value="Fibronectin type III domain containing 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000366">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000373">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000337">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="203"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="308"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="404"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="501"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="599"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="696"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="798"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="886"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1133" mass="124587" checksum="D613D926D283151D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ55</accession>
    <name>A0A401NJ55_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006318">
        <property type="protein sequence ID" value="GCB60900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ55"/>
    <dbReference type="STRING" id="75743.A0A401NJ55"/>
    <dbReference type="OrthoDB" id="10063284at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="321" mass="36894" checksum="63A79F25E3B33975" modified="2019-05-08" version="1">MSSLSTPTVEISQANTIEASDSAQTVGALSSNIQPTVDAFDTDDDHSGQDESTTEQAETEQKHETGSKFSHFKEYNSEEKPECKRDAKNLYHKLVKLEYAILTVVWEEVLERFNNTSKKLQTPGFDVFEGYLLLSSLLLFVKKLRENSADRIAHYESEAKGLCEDITSSYSDASKRIVTRKFSDGTSGIASLRGAEKFRIEVLYQLYDCLIIQLRKRIDQYEQIAKRFKFLSELVDNSEVDEDSIKLIISYYKDDIDHKLVNKCYQFKKYLHHRKSQNTEENTPSKMQCTEVLQLICEQHLIEVFASITTELKLNLTIHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLI7</accession>
    <name>A0A401NLI7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007691">
        <property type="protein sequence ID" value="GCB61724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLI7"/>
    <dbReference type="STRING" id="75743.A0A401NLI7"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="21908" checksum="CAED728811A88D26" modified="2019-05-08" version="1">MLNEAEFSPVDQISIQYWSEAARARYLFVKQQRDDKVNGDDSSEEEEGEVDSEVEFPRRQRPHRCMSSCQSYSTFSSENFSVSDGEEGNTSDHSHSGTPDGLSNNNEDRLEDKLDDMLSHTPEIPIEISMQSDGLSDKESAVRRVKTQISLGKLCAEEHCYENPMHFGESECDSSEAECSDATVRRGKACSSSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN88</accession>
    <name>A0A401NN88_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0013051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine + H2O = N-hexadecanoylsphing-4-enine + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
            <dbReference type="ChEBI" id="CHEBI:78646"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:45645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01006519">
        <property type="protein sequence ID" value="GCB62322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN88"/>
    <dbReference type="STRING" id="75743.A0A401NN88"/>
    <dbReference type="OMA" id="EENGHMS"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006684">
        <property type="term" value="P:sphingomyelin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09078">
        <property type="entry name" value="nSMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017766">
        <property type="entry name" value="Sphingomyelinase/PLipase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF8">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB62322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="529" mass="58573" checksum="AADEB94C1ABD32E8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNF3</accession>
    <name>A0A401NNF3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007790">
        <property type="protein sequence ID" value="GCB62403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNF3"/>
    <dbReference type="STRING" id="75743.A0A401NNF3"/>
    <dbReference type="OMA" id="TPVIYQW"/>
    <dbReference type="OrthoDB" id="6066926at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009039">
        <property type="entry name" value="EAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005492">
        <property type="entry name" value="EPTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051295">
        <property type="entry name" value="LGI_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367:SF10">
        <property type="entry name" value="LEUCINE-RICH REPEAT LGI FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03736">
        <property type="entry name" value="EPTP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50912">
        <property type="entry name" value="EAR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="274" mass="31728" checksum="FBA03772DAAD47B3" modified="2019-05-08" version="1">MESHSAVYCKPLVIEGQLYVVVAQLFRGSHIYRWDSYGGTFIRIQDIDPTRIRKPNDIVAFTIEGEQYFVIADSSKAGVSTIYKWSNGGFYSHHSLHPWHRDTDVEYVDVDNKPKLILSSSTQTPVIYQWNRAQRQFAYLTEIPNMLDVHAVKHFRVRKAVYLCLSHFIGDSRVVKWESQRFTEIQALPSRGAMVVQPFRVAQWQYVVLGSDFSFSHVYLWDAEKLGFDRFQDWSVRAPRAFQLVSIDGMHLVLAPSFKGNTVIYRHMVVDTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP87</accession>
    <name>A0A401NP87_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0007266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002596">
        <property type="protein sequence ID" value="GCB62664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP87"/>
    <dbReference type="STRING" id="75743.A0A401NP87"/>
    <dbReference type="OMA" id="AVEPRWG"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="164"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="266" mass="29572" checksum="35851E5ECE12E02C" modified="2019-05-08" version="1">MRISYEQKTENKIYTAEKNLRGQRFNKPGGADCLLKSVVLMRLSGVRGERQHVTMNSSLSGPTAVADVIKDLDSQIALIGPGPHNPKQKQDLEKLNDLKTKAQQIMNQFGPAALINLTNFPSIKPDPSSTPPPNTMANSTAVVKIPGTPGSGGRLSPEGNQVLSKKKLQDLVREIDPNEQLDEDVEEMLLQIADDFIESVVSAACQLARHRKSNTLEVKDVQLHLERQWNMWIPGFGSDEIRPYKKACTTEAHKQRMALIRKTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPR8</accession>
    <name>A0A401NPR8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0011541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005277">
        <property type="protein sequence ID" value="GCB62891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPR8"/>
    <dbReference type="STRING" id="75743.A0A401NPR8"/>
    <dbReference type="OMA" id="MAWRGPE"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02122">
        <property type="entry name" value="PA_GRAIL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF26">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019082096" description="RING-type domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB62891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="396" mass="43975" checksum="45E4013CC2FE2047" modified="2019-05-08" version="1">MRFWAPGLYFPFLLLLVTVSCRTAEWYTAFISTAYLDPDTNMTVSANSESGRYGDSSPKDSVQGVIGIPRANRDQLGCDPNTEYFISRSGEPWIALVARGNCTFKEKILNAAKKMASAVVIYNFLGTGNATVTMNHIGTGNTVAIMIGNSKGMEILELVRRGIPVIMSITVGTRHVQEWMSSQSVVFVIIAFITMMIISLAWLIFYYIQRFLYAGSQFSNQNKKNKNNRKEAKKAISKLQLHTVRHGDREVDLDIDGCAVCIEVYRYRDVVRILPCKHVFHRICIDPWLLEHRTCPMCKLDVIKALGFVVDAQENVEVVIPESVPGNIPVGNSDGALEEGAGAETSNFPSSPTFESLQHDDRLMEEDEAASLIEANLENQINSDSSSCPIGCPDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQZ3</accession>
    <name>A0A401NQZ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0013186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006638">
        <property type="protein sequence ID" value="GCB63296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQZ3"/>
    <dbReference type="STRING" id="75743.A0A401NQZ3"/>
    <dbReference type="OMA" id="NHKRHPA"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metalloenz_LuxS/M16"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="LA"/>
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    </dbReference>
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        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_LA"/>
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    </dbReference>
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            <end position="355"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="435"/>
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        </location>
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            <begin position="625"/>
            <end position="724"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
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            <begin position="105"/>
            <end position="117"/>
        </location>
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        <location>
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            <end position="133"/>
        </location>
    </feature>
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            <begin position="136"/>
            <end position="149"/>
        </location>
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            <begin position="150"/>
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        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
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            <begin position="707"/>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061352"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB63296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="918" mass="106781" checksum="EF8BAA6C7D7F326C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRW8</accession>
    <name>A0A401NRW8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi integral membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007945">
        <property type="protein sequence ID" value="GCB63610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ETHNQRY"/>
    <dbReference type="OrthoDB" id="6288648at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GOLIM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22909">
        <property type="entry name" value="GOLGI INTEGRAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22909:SF23">
        <property type="entry name" value="GOLGI INTEGRAL MEMBRANE PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
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        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB63610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="42399" checksum="81FC5E919642CDDC" modified="2019-05-08" version="1">MGNGMCSRRQKGLLQTGFCVLVVLCFGFGFYTYTHLNESLRSAEVLAQKYKQQQESVSAQLQVVYEHRSRLERSLQKERGEHKKTKEDFLVYKLEAQESLNKEKQDAMNRYGALSSQHKILKNQHDEIKKQLLDLQFQHNNLRLENRKASETHNLHFLQLHQQKDLELGTLQDSINKLKHESKQLRRAHQDMHQQLTEAQAQVEEFRQLKEALRAMPSFKHSGLNPAVLQEQNQARQEHPWGPDNNRSQVTQQKERPLQDELMSVEERAQSPQKNGEAGEKDQAREPVQGRPPLRNAPVWDLNNPPRPQDEGANRVLRFTRTVNSFQPDRQVRPHVDLMLFFWVHPFVTELCIEGSLGWGTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS17</accession>
    <name>A0A401NS17_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0000180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000031">
        <property type="protein sequence ID" value="GCB63691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401NS17"/>
    <dbReference type="OMA" id="FGDPAIC"/>
    <dbReference type="OrthoDB" id="5983569at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000008">
        <property type="entry name" value="agrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004850">
        <property type="entry name" value="NtA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03146">
        <property type="entry name" value="NtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51121">
        <property type="entry name" value="NTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019156095" description="NtA domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="NtA" evidence="3">
        <location>
            <begin position="35"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB63691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19208" checksum="D13A4BE9FE1BFACF" modified="2019-05-08" version="1">MSMGREGAGRVALPIHLSVLLLLLPLAVEFCWSLCPEKELESREEEANVVLTGTVEEIMNVDPVYNTYSCKVRVWRYLKGRETVKNEILLDGGNKVMICGFGDPLICDNQVSTGDTRIFFVNVAPKSMWPAHKNELLLSSSLMRITLRNLEEVENHVEGLDSFMCLFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSF0</accession>
    <name>A0A401NSF0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase HECW1 helical box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004046">
        <property type="protein sequence ID" value="GCB63795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSF0"/>
    <dbReference type="STRING" id="75743.A0A401NSF0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040524">
        <property type="entry name" value="HECW1_helix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18436">
        <property type="entry name" value="HECW1_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase HECW1 helical box" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB63795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8595" checksum="6655615EF84D8184" modified="2019-05-08" version="1" fragment="single">MEQLNRRYQNIQRTIATDRSEDEVTAEISQPNTELRREDSLSPVSSQKVNMLLQSPTVKFITNPEFFTVLHSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTT4</accession>
    <name>A0A401NTT4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Contactin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Axonin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0011731</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. Contactin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005441">
        <property type="protein sequence ID" value="GCB64303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTT4"/>
    <dbReference type="STRING" id="75743.A0A401NTT4"/>
    <dbReference type="OMA" id="NTHNYIF"/>
    <dbReference type="OrthoDB" id="6418794at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04969">
        <property type="entry name" value="Ig5_Contactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000047">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000052">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000054">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000064">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000600">
        <property type="entry name" value="Contactin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF28">
        <property type="entry name" value="CONTACTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019040216" description="Contactin-2" evidence="16">
        <location>
            <begin position="29"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="235"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="325"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="415"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="507"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="608"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="711"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="813"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="892"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB64303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114228" checksum="DF7FF5208949A55B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU08</accession>
    <name>A0A401NU08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 4 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001367">
        <property type="protein sequence ID" value="GCB64381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU08"/>
    <dbReference type="STRING" id="75743.A0A401NU08"/>
    <dbReference type="OMA" id="EFRDWCL"/>
    <dbReference type="OrthoDB" id="10047222at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056549">
        <property type="entry name" value="HTH_NOL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF22">
        <property type="entry name" value="NUCLEOLAR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23079">
        <property type="entry name" value="HTH_NOL4_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 4 helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 4 helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="714" mass="79271" checksum="FD910B3F92389ECD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVN5</accession>
    <name>A0A401NVN5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0014834</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01008117">
        <property type="protein sequence ID" value="GCB64946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVN5"/>
    <dbReference type="SMR" id="A0A401NVN5"/>
    <dbReference type="STRING" id="75743.A0A401NVN5"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB64946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16735" checksum="C942BE7853CBC355" modified="2019-05-08" version="1">MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW56</accession>
    <name>A0A401NW56_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0000376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000069">
        <property type="protein sequence ID" value="GCB65092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW56"/>
    <dbReference type="STRING" id="75743.A0A401NW56"/>
    <dbReference type="OMA" id="AGWPMAP"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072676">
        <property type="term" value="P:lymphocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20203">
        <property type="entry name" value="T-box_TBX21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000004">
        <property type="entry name" value="T-box, brain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032385">
        <property type="entry name" value="T-box_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF125">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16176">
        <property type="entry name" value="T-box_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="153"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB65092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="576" mass="64764" checksum="1574FAAD60295E90" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW86</accession>
    <name>A0A401NW86_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BtpA family membrane complex biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008137">
        <property type="protein sequence ID" value="GCB65143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW86"/>
    <dbReference type="STRING" id="75743.A0A401NW86"/>
    <dbReference type="OMA" id="ENFFDAP"/>
    <dbReference type="OrthoDB" id="10045006at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381:SF3">
        <property type="entry name" value="SGC REGION PROTEIN SGCQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="ZGC:162297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27210" checksum="C42BB4317F8A1D59" modified="2019-05-08" version="1">MPRRKLQEYLHQLEPVLIGEMKTCQSWSSSRSCGAGFAVSCWGWCTCDLVPEVTATMATICATVRHSYPNIPLGVQILSAANKQALPVALAADADFIRVEGFVFSQISGEGFLDACAGSLLRYRKQIGAEHIQIFTDIKKKHSSHGVTSDISVAETARAAEFFLSDGVILTGIATGMQTNPKEPMEIKQAVRIPAFIGSGVSVENVEEYMAADAMIIGSHFKKAGYWANEVDFERIKKFMTKINQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX17</accession>
    <name>A0A401NX17_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0004781</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-D-serine + H2O = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24874"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-serine + H2O = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21209"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01001435">
        <property type="protein sequence ID" value="GCB65404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX17"/>
    <dbReference type="STRING" id="75743.A0A401NX17"/>
    <dbReference type="OMA" id="TFCEDES"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000002">
        <property type="entry name" value="Phosphoserine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000077">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB65404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="242" mass="26404" checksum="ECBC087CB756993F" modified="2019-05-08" version="1">MVGAGSLLEPGRDLQSNMTTLAETKAILHSADAVCFDVDSTVIKEEGIDELAKFCGVGDDVAEMTRNAMGGAVPFMKALTERLAIIRPSREQVNKLITDHPPHLTEDIKILVDHLQQHGVQVFLISGGFRCIVEHVAAKINVPLSNVYANKLKFYFNGDYAGFDENQPTAESGGKGRIISLLKEERGFKKVVMIGDGATDLEACPPAGAFIGFGGNIVRQQVKEKAKWFVTSFKEIIEELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXY9</accession>
    <name>A0A401NXY9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Axin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0007777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002874">
        <property type="protein sequence ID" value="GCB65733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXY9"/>
    <dbReference type="STRING" id="75743.A0A401NXY9"/>
    <dbReference type="OMA" id="HIPHCPL"/>
    <dbReference type="OrthoDB" id="10007451at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
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    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
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    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
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    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0070602">
        <property type="term" value="P:regulation of centromeric sister chromatid cohesion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11582">
        <property type="entry name" value="Axin_TNKS_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08707">
        <property type="entry name" value="RGS_Axin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000002">
        <property type="entry name" value="Axin 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043581">
        <property type="entry name" value="Axin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014936">
        <property type="entry name" value="Axin_b-cat-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032101">
        <property type="entry name" value="Axin_TNKS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102:SF1">
        <property type="entry name" value="AXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16646">
        <property type="entry name" value="AXIN1_TNKS_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08833">
        <property type="entry name" value="Axin_b-cat_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4 7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="RGS" evidence="9">
        <location>
            <begin position="81"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DIX" evidence="10">
        <location>
            <begin position="762"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="621"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB65733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="93730" checksum="C242BB4D9942BBB2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYH1</accession>
    <name>A0A401NYH1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0000485</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000095">
        <property type="protein sequence ID" value="GCB65900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYH1"/>
    <dbReference type="STRING" id="75743.A0A401NYH1"/>
    <dbReference type="OMA" id="HCKVMVY"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031904">
        <property type="entry name" value="Cadherin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF236">
        <property type="entry name" value="PROTOCADHERIN GAMMA-C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15974">
        <property type="entry name" value="Cadherin_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019204721" description="Cadherin domain-containing protein" evidence="15">
        <location>
            <begin position="19"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="16"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="123"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="232"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="337"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="442"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="556"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="837"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="864"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB65900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="878" mass="96604" checksum="C08293C526EEE5E1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZE7</accession>
    <name>A0A401NZE7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Elongin 15 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">SIII p15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0014972</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (CUL2 or CUL5), a catalytic subunit (RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1, ZYG11B or RAB40C. Interacts with TMF1. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008268">
        <property type="protein sequence ID" value="GCB66246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZE7"/>
    <dbReference type="STRING" id="75743.A0A401NZE7"/>
    <dbReference type="OMA" id="ELMMAPN"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000016">
        <property type="entry name" value="Transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="16">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB66246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="112" mass="12501" checksum="36E068471B4C6F78" modified="2019-05-08" version="1">MDGEERTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZP5</accession>
    <name>A0A401NZP5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase-like protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0007863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. METTL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002928">
        <property type="protein sequence ID" value="GCB66346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZP5"/>
    <dbReference type="STRING" id="75743.A0A401NZP5"/>
    <dbReference type="OMA" id="VIGITWG"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF164">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE METTL23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB66346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26067" checksum="6329CC9B6D1FC1E0" modified="2019-05-08" version="1">MSGLPSAKRFVFAETSEAPPGGGARRLEVFVPEVLDPQYGMYIWPCAVVLAQYVWFYRNAIRGKTILEIGAGASLPGIVAAKCGARVILSDGAETPNCLDNCRLNCQINNLEDVPVVGLTWGQISPDLVLLPQIDIILGSDVFYEPKDFEDILITIFYLMQKNPHVLFWTTYQERSADWSIEALLYKWNLKCVHIPLKTFNANEQHLAGSSLPGSHTVHMMIITLRTSIPSATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1Y9</accession>
    <name>A0A401P1Y9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007078">
        <property type="protein sequence ID" value="GCB67141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1Y9"/>
    <dbReference type="STRING" id="75743.A0A401P1Y9"/>
    <dbReference type="OMA" id="WQDRVEC"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052830">
        <property type="entry name" value="RCC1_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849:SF1">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="258"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="359"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45191" checksum="2AE83A379ECB6492" modified="2019-05-08" version="1">MAAPGRWFGFGFNRFGQIVNRREHEADGTVSEPRAVTVPAQSPRQGEVERPASGSARAAAGRGGHRPAQRPPQISPAWSHTAYLTGDGSVYFFGFVGGHPWHQACTSNQGHQGCTDILSSEKYLLMLWQDRVECWDIQNLYTGEAVGDVTWTKKLKEEEERCSALPLIPDGYVTTAPPFYKPLSPQLRARKLALGTEHALLLSFDWTLHSWGSGRHGQLGHGSVEDEAEPRIVEALHGLAMAEVAAGSWHSVSASASGDLYVWGWNESGQLGLPTKSYSEEHQNPSQQKGLIAEGEDTPSPSDARDTVIKFKSEKAAEGDLNTFISIQAFPALLDLPEESEVSRVSCGSRHTAAITRGGKLFTWGWGTYGQLGHGHTDSSDLPQLVEYFVQNHLSVLDVVCGPWNTFVFARQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2Z0</accession>
    <name>A0A401P2Z0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0005140</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001574">
        <property type="protein sequence ID" value="GCB67482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2Z0"/>
    <dbReference type="STRING" id="75743.A0A401P2Z0"/>
    <dbReference type="OMA" id="IQPCHTQ"/>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF167">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10 15 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="19">
        <location>
            <begin position="252"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="20">
        <location>
            <begin position="1149"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="173"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="14 17">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="373"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="564"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB67482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1187" mass="133078" checksum="43F952838D08B093" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P436</accession>
    <name>A0A401P436_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005818">
        <property type="protein sequence ID" value="GCB67856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P436"/>
    <dbReference type="STRING" id="75743.A0A401P436"/>
    <dbReference type="OrthoDB" id="424503at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32329" checksum="15E7D453D85F0DD4" modified="2019-05-08" version="1">MVDEMKSWCMSKLQNLELKLSGELRSKSATPAGENMPETLSIDTIQSIREQRTSEACTAAQQAGEPTPQPYINLHCSLAEESGGAKVQSTDEMSGRQYFVVQQDAPSGTTQPGLTVPNSSTTTAQATCLPAVRPKERAAYSAPPAKAPLEQPLPKFGHVQFQTSIESSVVKSDQQVSGQPLRRYNQNKSTQTKKSLGLRHKQLQSSTLPSATQRMDQPSTQIKESSPVLEITQYFFEAVSTHMEKWYERKIEEARCQADQKAHQDKVALLEQVKSLEEELQKVRTKMQTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4Q9</accession>
    <name>A0A401P4Q9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004440">
        <property type="protein sequence ID" value="GCB68080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4Q9"/>
    <dbReference type="STRING" id="75743.A0A401P4Q9"/>
    <dbReference type="OrthoDB" id="10058156at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB68080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="14588" checksum="BDF29C83F8CD4BE2" modified="2019-05-08" version="1">METRYVIVEKEAFTVMWACKMFSDYIMGLKTAIELDHKQLASLFDEEELDLMPLRIQRPFRDLMMFAYEMIFVQGKKIDNSKHTFKGLPTKQDGNPIGQQVHLELMHDECGRICRYCYEGWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4W7</accession>
    <name>A0A401P4W7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHYHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005852">
        <property type="protein sequence ID" value="GCB68136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4W7"/>
    <dbReference type="STRING" id="75743.A0A401P4W7"/>
    <dbReference type="OMA" id="SPGDHFC"/>
    <dbReference type="OrthoDB" id="6101761at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042868">
        <property type="entry name" value="PHYHIP/PHYHIPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045545">
        <property type="entry name" value="PHYIP/PHIPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698:SF4">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698">
        <property type="entry name" value="PROTEIN CBG15099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19281">
        <property type="entry name" value="PHYHIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="331" mass="37546" checksum="6120D37D986E39DB" modified="2019-05-08" version="1">MELLSTPHNIKITSITCDSFKICWDTDAKDRERITHYFVDLNKKENKDSNKFKHRDVPTKLVAKAVALPMTVRGHWFLSPRTEYSVAVQIAIKQSDGEYLVSDWSEVVEFCTGDYSTAHLKQLLEKAEVIAGRMLRFSVFYRNQQEEYFEYIRTHHNGVMQPYLKDSSGSHGSPVNGTLHGIFFSCNTEFNTGEPQMDSPYGRLRLRVDAEHLFNPGTNLYFADFYCMYTAYHYVILVLAPKGTAGDLFCRERLPLLDSAHNPFLTCSQDPEGQLVFHHAQDLILELIYTQPLSLALGTLGEIGGHQLMSLSTANAKKDPSCKTCNISVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5A9</accession>
    <name>A0A401P5A9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007207">
        <property type="protein sequence ID" value="GCB68331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5A9"/>
    <dbReference type="STRING" id="75743.A0A401P5A9"/>
    <dbReference type="OMA" id="NDVEYAW"/>
    <dbReference type="OrthoDB" id="406745at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053251">
        <property type="entry name" value="N-glycanase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39319">
        <property type="entry name" value="SI:DKEY-256H2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39319:SF1">
        <property type="entry name" value="SI:DKEY-256H2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019373587" evidence="2">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="332" mass="36408" checksum="F5E005B85D0181D9" modified="2019-05-08" version="1">MGRGLGAWSLLLLLGLPRSGAGDISTEKLWMVKERVVYGDDSGLPGPRASLEGGWGSGSGAAAPPAPPPASGLEPGMLAPAFTLDTLDGELRFPPAKEQRPRSFIFQAFTNKSGFLECLWSCQASLVALVNRLPQRSHVVFLSFDDSASTDVRWMKRQLVGVMEERLKNISMFKDLLSRLHFVPIPVYALGNWIPAIFYAWRCQDHNCGLAQVAFTSPELKLTVVAKRLDARYDWIMKIWRSAPYILRDGGDGCNISSRVKGAVAFISDEGNCSYFTKVINMATSQALGVLVYVRPGLPLQDMNCQGAECLTAINIPASIMHFQKDVIDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5R9</accession>
    <name>A0A401P5R9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0015222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008527">
        <property type="protein sequence ID" value="GCB68446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5R9"/>
    <dbReference type="STRING" id="75743.A0A401P5R9"/>
    <dbReference type="OMA" id="NIWACHN"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF177">
        <property type="entry name" value="CYTOCHROME P450 2J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB68446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13406" checksum="AEDC00CAB4219077" modified="2019-05-08" version="1" fragment="single">KVHEEIDRVVGKERKPTSEDREEMPYTNAVIHETQSLGNVIPNSLPHQTYRDKEVMGYRIPKGTIIIPNLSSAMFDENIWSTPHQFNPGHFLNLEGKLVKPEAFIPFSAANVGDLRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P688</accession>
    <name>A0A401P688_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Scinderin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Adseverin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0013852</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the villin/gelsolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007244">
        <property type="protein sequence ID" value="GCB68637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P688"/>
    <dbReference type="STRING" id="75743.A0A401P688"/>
    <dbReference type="OMA" id="KKAGQKC"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000009">
        <property type="entry name" value="gelsolin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF78">
        <property type="entry name" value="SCINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="375"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB68637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="435" mass="48769" checksum="C63F8C22B14DF757" modified="2019-05-08" version="1" fragment="single">MVLYHKEFENAGKKEGIQVWRVERLELVPVPQGFHGSFYVGDAYLVMQTIVRSNNFSYNLHFWLGKECSQDESSAAAIFTVQMDDYLGGKPVQYREQQDYESTTFVGYFKGGLKYKVGGVASGFTHVVTNDLSAKRLLHIKGRRVVRATEVPLSWASFNKGDCFIVDLGAVIYQWCGSKCNKYERLKAAQVAAGIRDNERNGRAQLIVTDEGQEPKAIIQVLGQKPELSKGDDDEDIVADIANRKMAKLYMVSDASGSMKVSLMSAENPFSCDMLLTEECFILDNGADRKIFIQVLPEGGETPIFKQFFKNWKDKGQSEGFGKVYITETIAKIKQVKFDASKLHTSPQMAANHNMVDDGSGKTEIWRVENNGRIPVDPSTYGQFFGGDCYIILYTYRLGQIIYTWQGANSTKDELTMSAFLTVHLDRSLGGRAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6G6</accession>
    <name>A0A401P6G6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0008271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003132">
        <property type="protein sequence ID" value="GCB68722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6G6"/>
    <dbReference type="STRING" id="75743.A0A401P6G6"/>
    <dbReference type="OMA" id="EGVIKPM"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB68722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="368" mass="41279" checksum="0A448DDBF9E67B3F" modified="2019-05-08" version="1">MEGRYVSQKISRVRWRPTTGSSLQLPEYFASGSWDAEKNTVCIWDTVTEDTETDQLFLENTKPLCDIQHKGDVMELQFLDQERIVTASSTGSVIVFRHHEIDEVLSVVQQWERAHYHSHDSAPCTGLVCNGPEIITVGEDGRINHLQVDQKEPVRTIDDADSSSLNAVTFLRTTEILTVNSIGQLKIWDFRQPGNNPRQIYSLTGDRVPLHCVDRHPNQQHIVATGGQDGTFCIWDVRQGSIPISLLDAHSAEMWEVHFHPSNPDHVFTCSEDGSLWHWNASVIAPDLPSFLQQGRRNFSLNGTVAHADINQSLSSAWLTMDAAKGRVDIENLLWAYALSVNSLDVVGEHLVCGTDAEAIYITRTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6V4</accession>
    <name>A0A401P6V4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurogenic differentiation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0013883</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007269">
        <property type="protein sequence ID" value="GCB68848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6V4"/>
    <dbReference type="STRING" id="75743.A0A401P6V4"/>
    <dbReference type="OMA" id="SFKHEPA"/>
    <dbReference type="OrthoDB" id="10039134at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19722">
        <property type="entry name" value="bHLH_TS_NeuroD6_ATOH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022575">
        <property type="entry name" value="NeuroD_DUF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016637">
        <property type="entry name" value="TF_bHLH_NeuroD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF88">
        <property type="entry name" value="NEUROGENIC DIFFERENTIATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12533">
        <property type="entry name" value="Neuro_bHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015618">
        <property type="entry name" value="bHLH_NeuroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB68848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="404" mass="45977" checksum="D01D15590D52C0FE" modified="2019-05-08" version="1">MCHVLIASCLLDIRSCLWYGTSFLMSVCNRMVMVLTIRYLQRTSAMTKSYTENMMPETQSNPSWTDECLSSQDEHEADKKDDENEAMSLSFKVDTEELDKMGEDDDDDDEEDDEDEDDDEEEDEVDENEDQTPKRRGPKKKKMTKARVERFKMRRMKANARERNRMHGLNAALDSLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPHMQTASASFSVHPYTYQSPGLPSPPYGNMDSSHIFHIKPHSYAGALEPFFESTLTECTSPSFDGPLSPPLSINGNFSFKQEPSQEFDKNYTFTMHYPAATLAGPQGHNSMFSSTAPRCEIPIDNMMPYDAHSHHERVMSAQLNAIFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7T6</accession>
    <name>A0A401P7T6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Caspase-9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0010511</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004549">
        <property type="protein sequence ID" value="GCB69174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7T6"/>
    <dbReference type="STRING" id="75743.A0A401P7T6"/>
    <dbReference type="OMA" id="PFQEGPV"/>
    <dbReference type="OrthoDB" id="6044770at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08326">
        <property type="entry name" value="CARD_CASP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000012">
        <property type="entry name" value="Caspase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042147">
        <property type="entry name" value="CARD_CASP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CARD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="11">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="10">
        <location>
            <begin position="325"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB69174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47402" checksum="C222D1759B3206BC" modified="2019-05-08" version="1">MNEVQRKLLQRHRVRLVTSLRPDPLYDPLVAKEIFTEDMIEEIKNSGTRRDQARQLVTDLQTRGTRAFPAFLESLEETGQHELIELLREGLSVHDTSFTAVQPVEPWKGYKPVPRETWSSGPVQCTDTDLTVPRKPTMKKLQHDMIYKMDADPCGCCLIINNADFIQSSGLACRAGSDIDCENVQNLFQKLHFDVTVKRNLTKHLMIEELKNLARKNHKDFDCCIVVILSHGSQAQHRQFPGAIYGVDGGQPVPVQHIVSYFDGSHCPTLREKPKLFFIQACGGDLKDTGFRTAEEVDSAISTLNDPISLQTDATPSPAEDEPDARPSLPTTSDILVSYSTFPGYVSWRDKKEGSWYMKTLVQVFSKYAHSDDLQTLLTWVTRSISENEEAKGVYKQIPGSFNFLRKHFYFFNKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P916</accession>
    <name>A0A401P916_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Olfactomedin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004606">
        <property type="protein sequence ID" value="GCB69651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P916"/>
    <dbReference type="STRING" id="75743.A0A401P916"/>
    <dbReference type="OMA" id="GKSLECE"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF29">
        <property type="entry name" value="OLFACTOMEDIN-LIKE PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019289904" description="Olfactomedin-like domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="6">
        <location>
            <begin position="382"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="639" mass="73017" checksum="EFE1752C180D63D8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9E6</accession>
    <name>A0A401P9E6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0005534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001734">
        <property type="protein sequence ID" value="GCB69749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9E6"/>
    <dbReference type="STRING" id="75743.A0A401P9E6"/>
    <dbReference type="OMA" id="PCVSRFQ"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14683">
        <property type="entry name" value="PH-EXOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF20">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC3 PIP2-BINDING N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="874" mass="101203" checksum="597AFE1306520A7E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9T9</accession>
    <name>A0A401P9T9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Somatoliberin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Growth hormone-releasing factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Growth hormone-releasing hormone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_2000025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucagon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003249">
        <property type="protein sequence ID" value="GCB69921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9T9"/>
    <dbReference type="STRING" id="75743.A0A401P9T9"/>
    <dbReference type="OMA" id="VMCSISS"/>
    <dbReference type="OrthoDB" id="9931004at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016608">
        <property type="term" value="F:growth hormone-releasing hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031770">
        <property type="term" value="F:growth hormone-releasing hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051428">
        <property type="term" value="F:peptide hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030252">
        <property type="term" value="P:growth hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000532">
        <property type="entry name" value="Glucagon_GIP_secretin_VIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046963">
        <property type="entry name" value="VIP/GHRH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11213">
        <property type="entry name" value="GLUCAGON-FAMILY NEUROPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11213:SF6">
        <property type="entry name" value="SOMATOLIBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00123">
        <property type="entry name" value="Hormone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00070">
        <property type="entry name" value="GLUCA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00260">
        <property type="entry name" value="GLUCAGON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019568322" description="Somatoliberin" evidence="9">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glucagon / GIP / secretin / VIP family" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="173" mass="19512" checksum="43BC222FBBA35C9A" modified="2019-05-08" version="1">MLSRASLLMFCCLTVHTVCSPVYPDLRFENRSTLGRLFTSPVEESNIAEAGGVPETKESALDSTGERTERHADAIFTNTYRKVLGQMSARKLLQTIMGKRLSDSSLQEESEFLAKRHSDDIFTDTYARYQRQMAIRKYLAAILGNQRIENINMRQLPEDISAALEAAYGTNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PA01</accession>
    <name>A0A401PA01_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006063">
        <property type="protein sequence ID" value="GCB69920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PA01"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB69920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="85" mass="9074" checksum="054FA464AA7879DE" modified="2019-05-08" version="1">MCSSPAGGTTLPVGRAVSGRLEGGVAGAARWPGLNVRPILCRYCLLAFPPHPQPLRRCYRLLSARPPAGWSSAIRIHPSIDSKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAC3</accession>
    <name>A0A401PAC3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 25 member 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0005611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001771">
        <property type="protein sequence ID" value="GCB70127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAC3"/>
    <dbReference type="STRING" id="75743.A0A401PAC3"/>
    <dbReference type="OMA" id="LGYYRAF"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF5">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="100"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB70127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32384" checksum="BD552DF3976378EF" modified="2019-05-08" version="1">MQQNSKDSDSSQVVTSLKNCGIGAVSSCLATFLTFPVHKTIFRQQIHGFIIRKAVTQLYQEGLMKFYRGILPPLLAKTIQGTLLFGVYDGLIGNISTEGTFLHHRCIAGSLSGIIEALVLTPFERVQNVLQDHRKDVKFPNIQNILKKFNSYKFKDMLQLGYYRGFLPILLRNGTGSALYFSFKDPIKNSLLDQGVPSGISAFVSGSFNGMMICFILYPLSAVIANMQSHVGGEKMSLWNFIAKFWVSRAQRLLYIYRGGSLVILRSCITWGITTTIYELLKADHFPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE75</accession>
    <name>A0A401PE75_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0001565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000358">
        <property type="protein sequence ID" value="GCB71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE75"/>
    <dbReference type="OMA" id="NEREFYC"/>
    <dbReference type="OrthoDB" id="9388635at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35967">
        <property type="entry name" value="UPF0450 PROTEIN C17ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35967:SF1">
        <property type="entry name" value="UPF0450 PROTEIN C17ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019209549" description="NTR domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="4">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="403" mass="46782" checksum="626788B1322E165F" modified="2019-05-08" version="1">MLLIQVFSIVVLAKHINAKTKELRPQFGRTGRGSSPVGLQDPSVDLTKLSPKNRSDSSLPALNAFLEREEAPFQEYKIKNENSHAEGKLNHLDFFEKNNKRNESTERQNLKAPAKEHSERQERWQSNDLRGLLSTFHPDKSKLNRSPTYYSLLGKSMQSSSSMYLTHNYHQGARLYHQISVTHHVTKQGEKATTYNLDPEENRPRKNINYRTSDTFINGVNSSFVTNRHPSSLLYHFNILREDYNKELCSIECRKEKNEREFYCNSEFAISGIVHDIVSLGKGLRLVTLLVDSNGFYRMSRLYVTPDGFFFKVHILVVDTFNCRRSCPDLKFGGRYIMMGLIYHRRYTLPTWVQERVSGRLKPGDGVVRSSSYVRRYNRKRDQRVQLVRDGKCGGAFLRSWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEP0</accession>
    <name>A0A401PEP0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FIP-RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0001627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000373">
        <property type="protein sequence ID" value="GCB71592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEP0"/>
    <dbReference type="STRING" id="75743.A0A401PEP0"/>
    <dbReference type="OMA" id="CTPKEEP"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF0">
        <property type="entry name" value="BRUCHPILOT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FIP-RBD" evidence="11">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB71592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="25351" checksum="82D404536D12DB2A" modified="2019-05-08" version="1">MTAVCTPKEEPSGPLIIGQLPSYVEFEVLPLKQEALLAAISEKDANIALLELSSSKKKKAQEEVALLKREKDRLVQQLKQQTQNRMKLMADNYEEDHLKPSAQSDQTNHKLSPEQQIVQSLLELNQNRSKLKLYIGHLTALCQDRDSQILQGLTPPPSYGIDNNRATWEEELQKMSSEQLNTELEQCEKESSELQDYANTILQQIADHCPDILELVVNALEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI64</accession>
    <name>A0A401PI64_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002194">
        <property type="protein sequence ID" value="GCB72817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI64"/>
    <dbReference type="STRING" id="75743.A0A401PI64"/>
    <dbReference type="OMA" id="SHHICSI"/>
    <dbReference type="OrthoDB" id="2324346at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010855">
        <property type="term" value="F:adenylate cyclase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026919">
        <property type="entry name" value="ADGRV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682:SF1">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="7">
        <location>
            <begin position="208"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="370"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB72817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="769" mass="86042" checksum="B716548291B7B666" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ71</accession>
    <name>A0A401PJ71_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0006659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002285">
        <property type="protein sequence ID" value="GCB73180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJ71"/>
    <dbReference type="STRING" id="75743.A0A401PJ71"/>
    <dbReference type="OMA" id="RAENTEY"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000004">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="234" mass="26056" checksum="D8D6A3E89AB22E4C" modified="2019-05-08" version="1" fragment="single">GLKKMQASLKNVDCIIEVHDARIPLSGRNPVFEEALGVRPHLLVLNKLDLADLTNKQIVPAVTELIQKSDRFHRAENLEYCLMVIGVPNVGKSSLINAMRRMYLRKGKASRVGGEPGVTRAVLTKIQMCLRPLVVASGTILDHLVGEEVIADYLLFTLNKQQKFDYVERYQLGEPCDDLPTVLKKIAIKLGKTQKVKAITGVGNVNILMPNYSAAAYDFIRTFRKGELGKIMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJP1</accession>
    <name>A0A401PJP1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Troponin C, skeletal muscle</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0002496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000628">
        <property type="protein sequence ID" value="GCB73353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJP1"/>
    <dbReference type="STRING" id="75743.A0A401PJP1"/>
    <dbReference type="OMA" id="QHDARAY"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000107">
        <property type="entry name" value="Troponin C, skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF57">
        <property type="entry name" value="TROPONIN C2, FAST SKELETAL TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB73353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="20164" checksum="D835F1BDD6B5DA28" modified="2019-05-08" version="1">MRKYELSGGCQNKTEPMTEQQADARSYLSEEMIAEFKAAFDMFDIDGGGDISTKELGQVMKILGQNPTREELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEEAKGKSEEELAEFFRVFDQNADGFIDRDELKEIIQLGGEQVTDEEIDELMKEGDKNNDGKLDFDEWLKMMENVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJU9</accession>
    <name>A0A401PJU9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-soluble NSF attachment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002322">
        <property type="protein sequence ID" value="GCB73358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJU9"/>
    <dbReference type="STRING" id="75743.A0A401PJU9"/>
    <dbReference type="OMA" id="TEIRACK"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070044">
        <property type="term" value="C:synaptobrevin 2-SNAP-25-syntaxin-1a complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010807">
        <property type="term" value="P:regulation of synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000028">
        <property type="entry name" value="beta-soluble NSF attachment protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF12">
        <property type="entry name" value="BETA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB73358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32978" checksum="47816D787AAE2DEA" modified="2019-05-08" version="1">MDNSGKEKEAMQLMADAEKKVKSSHSFLGGLFGGNTRVEEACEMFARAANMFKMAKNWSAAGNAFCQAAKLHLQLQSKHDAATSFVDAGNAYKKADPQEAINCLNAAIDIYTDMGRFTIAAKHHITIAEIYESELVDIEKAVAHYEQAADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGTNTMDNPLLKYSAKEYFFKAALCHFIVDELNAKLALEKYEEMFPAFSDSRECKLLKKLLEAHEEQNGEAYTEAVKEFDSISRLDQWLTTMLLRIKKSIHGEGDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK37</accession>
    <name>A0A401PK37_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynamin-1-like protein</fullName>
            <ecNumber evidence="8">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">scyTo_0002576</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <location evidence="7">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01000654">
        <property type="protein sequence ID" value="GCB73497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK37"/>
    <dbReference type="STRING" id="75743.A0A401PK37"/>
    <dbReference type="OMA" id="CAYINTN"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
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    <sequence length="726" mass="80730" checksum="E9CD050EA15109BD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKW9</accession>
    <name>A0A401PKW9_SCYTO</name>
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        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein 1B</fullName>
        </recommendedName>
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        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
            <begin position="934"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1651"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1981"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2020"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2033"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2063"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2074"/>
            <end position="2089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2221" mass="244251" checksum="4137B14324899422" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PL24</accession>
    <name>A0A401PL24_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0002880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000747">
        <property type="protein sequence ID" value="GCB73798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PL24"/>
    <dbReference type="STRING" id="75743.A0A401PL24"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028027">
        <property type="entry name" value="SPMAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15075">
        <property type="entry name" value="SPMAP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="13">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="357"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB73798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="605" mass="69390" checksum="B31CE9A43754DAE3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLT5</accession>
    <name>A0A401PLT5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0003164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000844">
        <property type="protein sequence ID" value="GCB74079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLT5"/>
    <dbReference type="STRING" id="75743.A0A401PLT5"/>
    <dbReference type="OMA" id="HPWCNEH"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB74079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="390" mass="43907" checksum="BB1D69F84383C9BF" modified="2019-05-08" version="1">MNWIFPLSKSGGSGSGHLPPLTNLQQQRQRQIESVKSSHSGVVEIQKDVEYRLPFTVNNKTINLNIFLPPQFPQEKPVVSVFPPVRHHLVDKHSGTVVTSPLITNFTMHSDLGKIIQTVLEEFWKNPPIVASSAASFPYRFSGPAGMAPYPLQGYPFIGPFTTQESTVPCLPDSVPGQGFSSPRPAAPAYGLITDLPLPVPTTDSSEQLGLNGYSYKMPDVPEHFTELQELGTSQLTDLNDNEALLLEHFITLPQLKQICTDKDDLVNYIEELAKKNLHLEPRLEVERQELLDKYDQLTELKSTFEKKLERQHELSESCSLSALQARLKVAAHQAEEESDVIADEFLEGKVEIDDFLSSFMEKRTLCHCRRAKEEKLQHLMTQHGQFHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP42</accession>
    <name>A0A401PP42_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017452">
        <property type="protein sequence ID" value="GCB74902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP42"/>
    <dbReference type="STRING" id="75743.A0A401PP42"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF9">
        <property type="entry name" value="DCD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="88" mass="9679" checksum="1D77D575036E354C" modified="2019-05-08" version="1" fragment="single">YTHTFATVGELLYLFGGSTVENLYYKDIHVLDTVSLTWSQCEVKGEGPSGRGCHTFTSHHDKDIYVFGGSYDQGGSITTLNDVVKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPI0</accession>
    <name>A0A401PPI0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012375">
        <property type="protein sequence ID" value="GCB75033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPI0"/>
    <dbReference type="STRING" id="75743.A0A401PPI0"/>
    <dbReference type="OMA" id="DEVFLFM"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="49"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="21628" checksum="837679A606B1D87C" modified="2019-05-08" version="1" fragment="single">MSSDVATKVVENGYKANFKNINRYLDSDMQAVVYELNSNVEQRLDRVSDNKLLLFELCNIIKTATGADGLSLYFVGDCSNSLCLFTPIGFTDQKQRPVSAAPYGIAVASYVAKFKKTLLVQDLVEDNRFPKETWLDSTPPIQSVLCLPIVTTSNELIGVLELHRQRGRNPFDSEQQQIATANLAWALVAIHQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPU9</accession>
    <name>A0A401PPU9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011135">
        <property type="protein sequence ID" value="GCB75149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPU9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9510" checksum="668E3E06C4C558F9" modified="2019-05-08" version="1">MVCAVLVVQASQTPGFGLGGHRIAEISTRNLTIKSSKKMVSKRNTGNSRLERRIWRRVCEMFLAVSVSAFLDRCIEEKKWKDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQB0</accession>
    <name>A0A401PQB0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S15a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0017323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011163">
        <property type="protein sequence ID" value="GCB75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQB0"/>
    <dbReference type="STRING" id="75743.A0A401PQB0"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="108" mass="12094" checksum="24A90BDA909AD6E5" modified="2019-05-08" version="1">MDVKLHMDEASGILTNPLRKTVSRGCGAAGTSFSFRHIDRSGYIGEFEMIDDHRGGKIVVNLTGRLNKCGVISPRFDVQVKELERWQNGLLPSRQFGYQLLSELSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQQ5</accession>
    <name>A0A401PQQ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bardet-Biedl syndrome 7 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017640">
        <property type="protein sequence ID" value="GCB75452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQQ5"/>
    <dbReference type="STRING" id="75743.A0A401PQQ5"/>
    <dbReference type="OMA" id="HPKMEYQ"/>
    <dbReference type="OrthoDB" id="414590at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056335">
        <property type="entry name" value="BBS7_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23349">
        <property type="entry name" value="BBS7_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBS7 platform" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 helical hairpin" evidence="1">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24203" checksum="8EFF9BE58365D9B2" modified="2019-05-08" version="1">MNTLTLTGQFSFAEIHSWVVFCLPEVPDKVPVGDSVTFYFQNTFLETQLECSYKKGEGTFKSDNISTISILKDILTKEATKRKINLSISYDVNEESINYTLNLIHPKLEHQLLLAKKVQLIDALKELQLYEGNVDFLIPEYRCILEEADSLLEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDNYDPKSLMAFFDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSK5</accession>
    <name>A0A401PSK5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0020436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016494">
        <property type="protein sequence ID" value="GCB76087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSK5"/>
    <dbReference type="STRING" id="75743.A0A401PSK5"/>
    <dbReference type="OMA" id="TAHCTFL"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016501">
        <property type="term" value="F:prostacyclin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048662">
        <property type="term" value="P:negative regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000370">
        <property type="entry name" value="Prostglndn_IP_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF7">
        <property type="entry name" value="PROSTACYCLIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00856">
        <property type="entry name" value="PRSTNOIDIPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="42"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB76087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="287" mass="31432" checksum="B5876DA22B17C989" modified="2019-05-08" version="1">MGDSPDLQANGQNNRTCQTTIEILEDSKPVVSILMFSGGLVGNVLALVLLGMHRKEIRTKSSVFCILVTGLAVTDLMGTCFLSPVVFISYARERSLVGLVGDHTLCDFFSFAMTFFGMASTLILFAMAVERCLAISHPYFYSQHMGRGFAKVCLPVAYAFAASFCILPFVGFGEPRQYCPGTWCFLQMEPGNSAAVGFSLLYASLISCLIVAILVCNGSVIISLCKMHRSQRSRRGSVPSSQRRRKSWFGQREEEVDHLILLAAMTVIFAICSLPLTVSPVFLMSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTE5</accession>
    <name>A0A401PTE5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0021005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017862">
        <property type="protein sequence ID" value="GCB76404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTE5"/>
    <dbReference type="STRING" id="75743.A0A401PTE5"/>
    <dbReference type="OMA" id="VETEWHE"/>
    <dbReference type="OrthoDB" id="9936265at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000029">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000197">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF89">
        <property type="entry name" value="MYOMESIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="105"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="206"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB76404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="405" mass="45461" checksum="E69C0501AF262B64" modified="2019-05-08" version="1" fragment="single">SAAPSPPYHIVPVRNTRTSVMVLWKEPESEDELLGFYVYSCEVGTNNWETCNNKPVTSKSIEVHGLTPGKKYVFRVKSVNPAGLSEYSAESTPIVVNNAISLPSAPYGLTQLNSGKNEMVIGWKEPKFPIGAEILGYFLDYCDVETEWHEVNIEPIKEKIYKVQNLNEGSLYQFRAFAMNWAGVGQPSEASDQFKCEEWTMPQPGPPFDVRFLEVRSTSLLLQWQPPLYTGVEPVTGYVVEMCETDLEDWKTLSDKPILKAQMRISHLEEGKTYIFRVLALNSAGTGLPSLPCDPVRTETRPGTTELEVGVDEDGNIFLALQNPEAADAPKFIWSKDYQEITTPERVRIETTENVSKLIFIDPSEEDLGTYSVVVTKTDGVSSSHTLTDEELQSLKKQSHRKRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTF6</accession>
    <name>A0A401PTF6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013954">
        <property type="protein sequence ID" value="GCB76411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTF6"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9240" checksum="D5981A50187C288A" modified="2019-05-08" version="1">MGIYSSNFHRSGGQLLLESTDPSQANWITAHAEACQLTIPEVQRCWSRFLLLQPDRNGNVLRSRFLTVERFNHQGGISLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTT6</accession>
    <name>A0A401PTT6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0019898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015294">
        <property type="protein sequence ID" value="GCB76522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTT6"/>
    <dbReference type="STRING" id="75743.A0A401PTT6"/>
    <dbReference type="OMA" id="FQWGYEM"/>
    <dbReference type="OrthoDB" id="5835702at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB76522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21109" checksum="53857280326D7D05" modified="2019-05-08" version="1" fragment="single">DKLLDANTVTHLFRITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYDIPVDMLCKRIADISQVYTQNAEMRPLGCCMILVGVDEELGAQVYKCDPAGYYCGFKATAAGVKQTEATSFLEKKVKKKLDWIYAQTVETAITCLSTVLSIDFKPSEIEVGVVTVDNPKFRILSEAEIDTHLVALAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTX7</accession>
    <name>A0A401PTX7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010101">
        <property type="protein sequence ID" value="GCB76599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTX7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="9758" checksum="2845572D693758DA" modified="2019-05-08" version="1">MCNDCYIHQSVKTLHVPVPGRTNELPRFLAKPRWARAVITVRAGASPRGSCTPLRKGCYYPAETMAAGLVINLPLLTQASEAADRFTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW82</accession>
    <name>A0A401PW82_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 4H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0017599</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011574">
        <property type="protein sequence ID" value="GCB77414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW82"/>
    <dbReference type="STRING" id="75743.A0A401PW82"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12401">
        <property type="entry name" value="RRM_eIF4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000115">
        <property type="entry name" value="eukaryotic translation initiation factor 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034229">
        <property type="entry name" value="eIF4H_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB77414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10359" checksum="921D32D45337CE1F" modified="2019-05-08" version="1">MFRRSRVSGPRKQKELPTEPPFTAYVGNLPFNTVQGDIDAIFKELSVRSVRLVRDKETDKFKGFCYVEFDDLDSLKEALTYDGAVSIFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWF4</accession>
    <name>A0A401PWF4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin polyglutamylase TTLL2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011579">
        <property type="protein sequence ID" value="GCB77438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWF4"/>
    <dbReference type="STRING" id="75743.A0A401PWF4"/>
    <dbReference type="OMA" id="CKWTMSQ"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF118">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB77438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="73568" checksum="5DE2851DD245DB21" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWX4</accession>
    <name>A0A401PWX4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016862">
        <property type="protein sequence ID" value="GCB77637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWX4"/>
    <dbReference type="OrthoDB" id="9425890at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="166" mass="18107" checksum="0168338757D70D50" modified="2019-05-08" version="1">MDENPPDISTSETDEVGTSSTLDDVAKPNVPPGSGSSGKESESDIQSRSDLCDRNLEGASRVRTPCPVLEEDAELSCSGTAAGLTSVLDDEVPEDQNMEPDTTAPLPSPDPTEKQEGNVEPTLRLKDKETLFMLLALHMEESPLCENPMRHKSDRKEKKIMVRKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ28</accession>
    <name>A0A401PZ28_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptor 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0018599</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013104">
        <property type="protein sequence ID" value="GCB78382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ28"/>
    <dbReference type="STRING" id="75743.A0A401PZ28"/>
    <dbReference type="OMA" id="WRQPACA"/>
    <dbReference type="OrthoDB" id="6069656at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15163">
        <property type="entry name" value="7tmA_GPR20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000243">
        <property type="entry name" value="G protein-coupled receptor 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="65"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB78382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="352" mass="40018" checksum="50140FFF7F293BF8" modified="2019-05-08" version="1">MQNTTVEPNLANVTTAYLSNGTHNHKEPYLHKLAHLDEALYNDYYSLWLALMIINVIICVVGIALNGVALYVFCFRTKTKTTPVIYTINLVITDLMVGFSLPTRIIMYYSGGECLTCSFVHIFSYFVNMYCSILFLTCICVDRYLAIVQVEASRKWRNPHYAKGICVFIWLFAIIVTYSILTTAIKYASCCLSKLFALTVFEYFLPLVIITVFTIRIMCALAKPNLMQQSRERRMRAVQLLVTVLIIFMICFTPFHVRQVVVYAHPTLPHHISLIVYHVTVTLSSLNSCLDPIVYCFVTNNFQSTVRNIFVKAEHEQNSGEVISVQKSSKVSTEKTVVSNMVMNGPSPDSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZZ3</accession>
    <name>A0A401PZZ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015812">
        <property type="protein sequence ID" value="GCB78686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZZ3"/>
    <dbReference type="OrthoDB" id="10254483at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000043">
        <property type="entry name" value="SH3 domain binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035848">
        <property type="entry name" value="SH3BP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15126:SF4">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15126">
        <property type="entry name" value="SH3-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10520" checksum="218749AC1B8CE2B0" modified="2019-05-08" version="1" fragment="single">LFGSTSPGSNPENGLYCIRNSSKSGKVLVVWDDSEMKVRNYRIFEKEAKFFLEAEIKFTCLASMVEFYYKHALPTHDRLHLRVPYGCKNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0M5</accession>
    <name>A0A401Q0M5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017162">
        <property type="protein sequence ID" value="GCB78843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0M5"/>
    <dbReference type="STRING" id="75743.A0A401Q0M5"/>
    <dbReference type="OMA" id="WWAGMSA"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="11907" checksum="304DB579152B8FD1" modified="2019-05-08" version="1">MTDVHFLQDPESITYSQGKEVKLRCSIQVTGELPEINWQRDGARYRADVNQVLVPVNDDEWLAISELSIPSIHRSDAGSYRCVVSVTGKEVLSKEAQLEIEGGSFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1D6</accession>
    <name>A0A401Q1D6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0020181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015952">
        <property type="protein sequence ID" value="GCB79207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1D6"/>
    <dbReference type="STRING" id="75743.A0A401Q1D6"/>
    <dbReference type="OMA" id="DFESTHI"/>
    <dbReference type="OrthoDB" id="6419934at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039147">
        <property type="entry name" value="ASB17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="242"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB79207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="291" mass="33832" checksum="7E47D60AE5EE67B7" modified="2019-05-08" version="1">MSDDAERCCKGPEVRQTVFGELLEKVAVKRILGPVYRNWEPLIYHTLSHVLRHVDAPGFDSLLSDYIAFVHWPRDKRCLSFYLEFTEICINTILYWLFARKVNPPLVQKLLERTASYLGDRGNQLALIWRTFTPVYNPNPLCGVTPLHFVAQNRQSDILKILLQYGILEREESPMSTILIILFYPTSIARVHDFESTHIIEEAKLCLSLCVRVTYRIHVSQIKAYINFRQQPLISNWLNCIPVTRYQEVCELLHLCRMCIRNCLLTSSGLPRGISLLPLPKSLQNYLNLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q236</accession>
    <name>A0A401Q236_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial transcription termination factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011992">
        <property type="protein sequence ID" value="GCB79416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q236"/>
    <dbReference type="STRING" id="75743.A0A401Q236"/>
    <dbReference type="OMA" id="VVIRCPA"/>
    <dbReference type="OrthoDB" id="9868878at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006393">
        <property type="term" value="P:termination of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437:SF1">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43413" checksum="CA24BD649FCBB141" modified="2019-05-08" version="1">MVGLGLLYGGRCSGHRFSSALWSREMYRGSLQFSTCAVKRKENRQTVDSLDQLSVDVTKIRQLKSWVLLADVAYVNEIANILKEMGAEGKKIALILERYPEAVLCTPAEISAQRELWGKLCSNEEELVRIVERFPESFFTVRNHRNRQDNIKYFQTLNLNKRIISRLLASSPQIFCSSVDRNKTVIETLQQSYLQLGGTQADMRVWLMKLLSQNPFILLKPPEAVCENLTFLQSLGFSSAERLKLLSKLKGLIIELSPSTMENCAVFCHQALQCTDEGLKMILLSCPALLYFSVPVLEGRLGAILKEGFSVEQVRASPAVLELSTQIVHHRIRRLVALGYNVKRDSLELLNGTKKDFESSCGKMDWRKQRPLFNPVAPLNIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q506</accession>
    <name>A0A401Q506_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012334">
        <property type="protein sequence ID" value="GCB80463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q506"/>
    <dbReference type="STRING" id="75743.A0A401Q506"/>
    <dbReference type="OMA" id="ACFGRRI"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000001">
        <property type="entry name" value="Arylsulfatase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF9">
        <property type="entry name" value="STERYL-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB80463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="276" mass="30977" checksum="DA94978CFB108F33" modified="2019-05-08" version="1">MHLRFEISGQILASLEMLNLSSRTLVYFTSDQGAHIEEISESGEVHGGWNGIYKGGKSTNWEGGIRVPGLLRWSGVLTAGRSIDEPTSNMDIFPTIVKLSKAAMPSDRIIDGRDLMPLLLGDVQHSEHEFLFHYCNSYLSAVRWHPRHSSSVWKAHLFTPNFNPEGTQGCFDTHVCLCYGDYVSRHDPPLLYDLSCDPTESSPVTPASEPQYHQILDVMQEAVERHRGTLTPVPDQLTLNNIIWKPWLQPCCSTVWEHCHCDNDTNSNTALNGTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5T5</accession>
    <name>A0A401Q5T5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neuroblastoma suppressor of tumorigenicity 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0016346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009825">
        <property type="protein sequence ID" value="GCB80707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5T5"/>
    <dbReference type="OMA" id="HKHTEPH"/>
    <dbReference type="OrthoDB" id="8196271at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000016">
        <property type="entry name" value="Neuroblastoma suppressor of tumorigenicity 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF5">
        <property type="entry name" value="NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CTCK" evidence="8">
        <location>
            <begin position="71"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB80707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="204" mass="22759" checksum="AADC44CB9C15748F" modified="2019-05-08" version="1">MGCRGRNSLTQRPLTKRQSSTFLRQPRTMVEQLTMMCWSLLGILLPALVVAAPPPINKLALFPDKSAWCEAKNITQIVGHTGCESKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVMLECPGNEKMPRVDKLVEKIVHCSCQACGKEHRQDSQLFNVIVNEEEASAPELVGSPQIVHHDEQVALKHGREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q603</accession>
    <name>A0A401Q603_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024944">
        <property type="protein sequence ID" value="GCB80791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q603"/>
    <dbReference type="STRING" id="75743.A0A401Q603"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7621" checksum="68079D4C208DA03D" modified="2019-05-08" version="1" fragment="single">SENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDKKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q671</accession>
    <name>A0A401Q671_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023733">
        <property type="protein sequence ID" value="GCB80866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q671"/>
    <dbReference type="STRING" id="75743.A0A401Q671"/>
    <dbReference type="OMA" id="CSCYRGT"/>
    <dbReference type="OrthoDB" id="1600340at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000032">
        <property type="entry name" value="Slit homolog 2 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF196">
        <property type="entry name" value="RETICULON 4 RECEPTOR LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019217876" description="LRRNT domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="6">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB80866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="128" mass="14366" checksum="C858BF4BEF273DD5" modified="2019-05-08" version="1">MGPFGFWRVSCCFLLVIGTNTWREVAAQVCPNHCTCAGTAVDCHGLGLRSVPKSIPRNTERLDLNGNNITRISKSAFSGLRHMRVLQLMENQITTIERGAFQDLKELERLLPGILGLEVKEDKARKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6F6</accession>
    <name>A0A401Q6F6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0022437</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022502">
        <property type="protein sequence ID" value="GCB80948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6F6"/>
    <dbReference type="OMA" id="IHAENPM"/>
    <dbReference type="OrthoDB" id="8836910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF14">
        <property type="entry name" value="BUTYROPHILIN SUBFAMILY 2 MEMBER A2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB80948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="145" mass="16023" checksum="61AB42752A56A8FF" modified="2019-05-08" version="1" fragment="single">DINCKKKGKDVEAKEGEAASLPCSFSDPTKYNKLEVTWQREVGENAVVIHAENPMGKSEESQDRLFSGRTSIPSSWNQTGDTTLTIRQAQEEDSGNYTCIIRGGGRPAYCAFLLLKVNSGSFQLYGGHHSVWIPFLLLVLMQVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6F8</accession>
    <name>A0A401Q6F8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023799">
        <property type="protein sequence ID" value="GCB80956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6F8"/>
    <dbReference type="OMA" id="GMMDTAA"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF209">
        <property type="entry name" value="FORKHEAD BOX PROTEIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="265" mass="29151" checksum="EEC4791AE614BED0" modified="2019-05-08" version="1">MLPLSEIYKFIMERFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPNCGDMFENGSFLRRRKRFKVLKADHLSMGKQSEAAHYLQQQAKLRLSALAVSGTHLPQMPSYSMAGSQGSSFKHPFAIENIIAREYKNVMASGLTFSAVQPMHTAYPMHSQLTSVGSSLGSTWSHMYNAMDTAPPLPGDYSPYGLPLKPLGQGGQTLPAIPVPIKAISAILSGSSPALSPTSPAAHRSPSPGDTLTGSVLQPVTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7A4</accession>
    <name>A0A401Q7A4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021387">
        <property type="protein sequence ID" value="GCB81248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7A4"/>
    <dbReference type="STRING" id="75743.A0A401Q7A4"/>
    <dbReference type="OMA" id="SEMQVEC"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF101">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="6">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="262" mass="27427" checksum="27BCE4921ED7793E" modified="2019-05-08" version="1" fragment="single">VIKQQKEAFKLPIPSPQASKPAPTDPTVLIGGVSIKLKQGDITQEITDAIVNSTNTTLDLNSGVSGAILNAAGSSVQDECKALGQQLADGVAITNSGQLQCKYIVHIVGPKSAAGITASVHKALEECEKRSITTIAFPAIGTGKGGISCLTAINAVFSGMENYFLTIVSSNIKAISIVAFESYVYDSFADAFEAKKLNSGVGTMGTAQMTQHIYTQTAQKGGLLPTQLRIRNVIVEVQQGNITLQSVKGIVNSTNTTLDLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7K3</accession>
    <name>A0A401Q7K3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021470">
        <property type="protein sequence ID" value="GCB81374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7K3"/>
    <dbReference type="STRING" id="75743.A0A401Q7K3"/>
    <dbReference type="OMA" id="GIICKNM"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="1">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="328" mass="36579" checksum="26ECC599BA5D8944" modified="2019-05-08" version="1" fragment="single">NSPQSPYKTLNEALSSVESFEKHYLDLSHTAIEMYQTIGQVRSSQLLGKDLADFYMRKGEPQKAEMYLQEALKTYQAEGWPLLIAHTRKQLAECQKQLQQTQNYLQTSSLLAGDDNLTETERIHFCQEILNLTQQPDSGQDDRLLLGMEGFLQLQSLCFKPVCAMVHVGGLLEIELTVHSLMPLPVHLHQLSIHLNLSVSKDTSKRGSELGSRSRNVNGIFLFPSGPIGHPSPRNKQPFIELCELYEQSPSDSSLNSSGIICKNMHLLFGRQESSSSLERSSGLAVEDAAHVLRTTDILLKPGINTIHFKTEASAFKTQNTKNNGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7P8</accession>
    <name>A0A401Q7P8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0023141</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with IL8. Interacts with GNAI2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026695">
        <property type="protein sequence ID" value="GCB81392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7P8"/>
    <dbReference type="STRING" id="75743.A0A401Q7P8"/>
    <dbReference type="OMA" id="GNQTTKW"/>
    <dbReference type="OrthoDB" id="9946013at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016494">
        <property type="term" value="F:C-X-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15178">
        <property type="entry name" value="7tmA_CXCR1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000174">
        <property type="entry name" value="Chemokine_CXCR_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF930">
        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00427">
        <property type="entry name" value="INTRLEUKIN8R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
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        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="100"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="177"/>
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            <end position="235"/>
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            <begin position="247"/>
            <end position="269"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
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        <location>
            <begin position="59"/>
            <end position="310"/>
        </location>
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        <location>
            <position position="1"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB81392.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="352" mass="40209" checksum="A97A093226472273" modified="2019-05-08" version="1" fragment="single">KIMEFDDLEKWQKYFDNYSDYEEFYLDPVTFACTPIVNESINVVIAVVYSLVCFLAVTGNMVVMVVIFYNRRIMSSTDIYLLHLAVADLLFAVTLPFWAVDAISGWVFGDAMCKIISLLQEVNFYSGILFLACISVDRYLSIVYSTKIHQQKGPFLIKVICAAVWVLAILLSLPILYKGEYTPAGIDRTMCYEILDGKSAETWKITTRFLRHIIGFLIPLAVMIFCYSVTIWRLCQTRGFQKQKAMKVIIAVVLAFLICWLPHNITVFIDTLMRSKYIDYICDRRKHIDRALIGTQILGFLHSCINPILYAFIGVKFRNNLLKLLAMIGIIKQSEEIHQKASTSLSSVSGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q854</accession>
    <name>A0A401Q854_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020269">
        <property type="protein sequence ID" value="GCB81564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q854"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="34" mass="3844" checksum="4413017E48A8DD2E" modified="2019-05-08" version="1" fragment="single">MIETFHTITKLFYTVLAVVGVIVNLVAILILIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Y0</accession>
    <name>A0A401Q8Y0_SCYTO</name>
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        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PRY"/>
    </dbReference>
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        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="31"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="228" mass="26186" checksum="ED7F64575B585469" modified="2019-05-08" version="1" fragment="single">GEHRWRKRTTDNYKSLPPIQADLSLGIFKGPLQYAALKEMMITINPAPAPLTLDPRTAHCRLFLSEDLMEVRHGDFRQQLPETPERFSPYVCVLASEGFTSGRHYWEVAVTDKTKWDVGVARESVDRKGNDAPTPDTGYWMVWLRNGRDYWAVTSPRTRLSPRARPRKIGVFLDYEGGQVSFYNADDMSHLHTFTHTFTGRLFPYFSPCLNEGGRNSEPLRICCTAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9J7</accession>
    <name>A0A401Q9J7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0023201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027133">
        <property type="protein sequence ID" value="GCB82064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9J7"/>
    <dbReference type="STRING" id="75743.A0A401Q9J7"/>
    <dbReference type="OrthoDB" id="2984333at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF62">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB82064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9379" checksum="96464523E5B8DABD" modified="2019-05-08" version="1" fragment="single">YLTLAFPRIPGLSALRAFRALKMIAILPGLKTIIGAIFKSARLLMEVLLLMMFVLLIIALFGLQIFKGDITYETLWLDRVVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAE3</accession>
    <name>A0A401QAE3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0021590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019413">
        <property type="protein sequence ID" value="GCB82354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAE3"/>
    <dbReference type="STRING" id="75743.A0A401QAE3"/>
    <dbReference type="OMA" id="YEINIVP"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF100">
        <property type="entry name" value="ANNEXIN A10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB82354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="15110" checksum="FDF41EA5FB4C19A5" modified="2019-05-08" version="1">MLLPNEHIFFQIQDLVTDLKEKLSNHFQEVIVGLMYPPAFFDAYQLRNAMKGIGTDENCLIEILASRTNDEINAINEVYLMQFDVPIQFDVESETSGHFRDALVILTQVFCNLLIWYPVCFVFYEINIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB13</accession>
    <name>A0A401QB13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0022693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023550">
        <property type="protein sequence ID" value="GCB82575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB13"/>
    <dbReference type="STRING" id="75743.A0A401QB13"/>
    <dbReference type="OMA" id="PLWSIRD"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB82575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="17751" checksum="42A36285DC69F433" modified="2019-05-08" version="1" fragment="single">RFREGLKVLGVLENIQKYPEIFAELLCYKPQKLTAEKFENLFSINFSPEESTRRIAESRVIGFWRNYLADIEDGTTKASFEQILTFATGTSASPAISFLPNPSIKFLHSDGIIQYRFPTGQTCLNCLKLPMSKTYEEFKECVDFAIFNTPGLKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBM6</accession>
    <name>A0A401QBM6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0023865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034949">
        <property type="protein sequence ID" value="GCB82779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBM6"/>
    <dbReference type="STRING" id="75743.A0A401QBM6"/>
    <dbReference type="OMA" id="SHDISEW"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018533">
        <property type="entry name" value="Forkhead_box_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09354">
        <property type="entry name" value="HNF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
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        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
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            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB82779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="302" mass="34242" checksum="845B8E41850F14CA" modified="2019-05-08" version="1">MSQALGSLALSPALNRGKELKPYRRNFSHAKPPYSYISLITMAIQQASNKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVPRSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCQKEKLLSRPPLEPGIKGLESGGEGKDSSPSSEDTGSSRSDTSPGSEEQRTLTELGCRRADNPSSVSGPSPSPAAMHQNMVHHLHPPAVQHLPDLQNELKMDPHYSFNHPFSITNLMSSEQPHKMDLKLYDQPVHYNNTYNTLLGKSGFETPAAMNDPSSYYQVMYNRSILNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBU8</accession>
    <name>A0A401QBU8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01032492">
        <property type="protein sequence ID" value="GCB82826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBU8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="42" mass="4239" checksum="09E30316DECE520F" modified="2019-05-08" version="1" fragment="single">ATTDGTSKQGQVFSSDTASGIKGQTNGALKMSTKDKATYAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBZ0</accession>
    <name>A0A401QBZ0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030061">
        <property type="protein sequence ID" value="GCB82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBZ0"/>
    <dbReference type="STRING" id="75743.A0A401QBZ0"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="466" mass="48518" checksum="D58E2DFD902BE275" modified="2019-05-08" version="1">MPGAEPDSTSGTLPVQTENAASPSPPDMVDLTEPIDQGVADEVLDLSCRLAELPIDSGQDSDSVVLLDSSPSPTDASTTEEEEGAVAAGPGPAGCQSAGSPAILSPIVQDGPRRFSSQGHGVESEVEMAASGLRSPDSKPLFQPDFNLVLEETMEEGENEQNEEKPVSANSSCSSIGAQPPASPGMGFLGSEEGNSDILLPGKKPRVLPSDSDEESEGDLHPVRAPEKPPCQFVTSPMLKGFNVAATSTPKGLTPPLAALLNRSLNHSVASRHSMVSQVLDDVEDMDDATPVGALGVDDGETDDNVSGQSGGEESAGEQTAESSQSPPGGRSVEESRAEGSSELGMGSDDEGVSDSSSSMATGSNEEAESERSGTFDPELGSGEQLETFTKATDQQQSVTNDRAAGDRVEPTLGEYEKLVKDGREQMERGELKAALKSMLQALDLSSGDPEVQLTTIKLYRQLDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC59</accession>
    <name>A0A401QC59_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0023373</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01028808">
        <property type="protein sequence ID" value="GCB82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC59"/>
    <dbReference type="STRING" id="75743.A0A401QC59"/>
    <dbReference type="OrthoDB" id="10006362at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000095">
        <property type="entry name" value="Adenylate cyclase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19071" checksum="1A457578BEB03CC0" modified="2019-05-08" version="1" fragment="single">SKLREATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITDATLRHLDEAYQVQEGSGHLRDPYLKEHQVTTYLVIDPRAEEHYLEATLALDPSDSAKIRASVRMTRYLESWGAAKPFAHLNQRDSLPVETPTFNHMDIPMGNLGSYRNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCD3</accession>
    <name>A0A401QCD3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030245">
        <property type="protein sequence ID" value="GCB83031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCD3"/>
    <dbReference type="STRING" id="75743.A0A401QCD3"/>
    <dbReference type="OMA" id="NIQRILC"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8775" checksum="E64C8129756E4B43" modified="2019-05-08" version="1" fragment="single">IRGFVNAISPNKNDKEDLVAFRFYAFNPIVDPWLFIILRKSVFRNIQRILCCRFSVSLHNTAFEDPLKQQSISLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCS8</accession>
    <name>A0A401QCS8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029235">
        <property type="protein sequence ID" value="GCB83189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCS8"/>
    <dbReference type="STRING" id="75743.A0A401QCS8"/>
    <dbReference type="OMA" id="HEPEPLC"/>
    <dbReference type="OrthoDB" id="9420729at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF7">
        <property type="entry name" value="SOUL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10363" checksum="A802500240DB7E21" modified="2019-05-08" version="1">MAYYLPTQFQDQTPQPFDAEVAIEEWPAHIIYARPFNGNTTEELILQEINQLAVHLDSPEWFLQDTFIVAGYNSPAAPNPHNEIWIIHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEQ0</accession>
    <name>A0A401QEQ0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01039850">
        <property type="protein sequence ID" value="GCB83869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEQ0"/>
    <dbReference type="STRING" id="75743.A0A401QEQ0"/>
    <dbReference type="OMA" id="NIGGTRQ"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="55" mass="5859" checksum="D00DBE91BDB77B2C" modified="2019-05-08" version="1" fragment="single">ILLICIAMLSAYSIHLLLRSAGFVGIRAYEQLGHKAFGQPGKIVAAVIISLHNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QET0</accession>
    <name>A0A401QET0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01039701">
        <property type="protein sequence ID" value="GCB83852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QET0"/>
    <dbReference type="STRING" id="75743.A0A401QET0"/>
    <dbReference type="OMA" id="NHLGLHY"/>
    <dbReference type="OrthoDB" id="9991614at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024812">
        <property type="entry name" value="TPR_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47050">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47050:SF2">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="40555" checksum="CD23AD935A5D481A" modified="2019-05-08" version="1">MSSDVATPTELASAGLAQPENKRKCARSKRRQDGGEAAEGDQDPLETQAEIESLTRAGSQSLARDCTEEALAAFKKAFLVSLDVREQWVQRACAFNLGAAYVASGRPEKGLNFLLRSQPATGGEREGDLHFNLGLAREGLGDLPRAMEHYQQALGHYRGGQAQGEADTFMKLASCQARVGEAAQAGRCFQRAGRAYRQAGSPDLAAVALNEAACHMLRCQRFSAREIAEVLYECRTVCGNIQNKALLGKLYNDVGLSYAQVKIFQQAAECFELALPHCRRGSSEQRKEAVVLQNLGAVYNTMGGYSRALGFHQSAATLHGEERGNGRALGVGGGGQGGIRAPPPPADLSQGQGSTVGEGRCQGEVRGGEGVWTGDPDRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF35</accession>
    <name>A0A401QF35_SCYTO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024509</name>
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    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
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        <lineage>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="36" mass="4058" checksum="AD4C45F1DB9D42D7" modified="2019-05-08" version="1" fragment="single">MMLEELVSEEMVSEEVLSEEVVSEVLVSEEIVNEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401QGI6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01075547">
        <property type="protein sequence ID" value="GCB84489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10367817at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="8461" checksum="8EEF7EAEB152EF67" modified="2019-05-08" version="1">MQPRAGKRCRGRPRVRTEQERKERKRQWHRNRCQRSVYLGAESERWKELRKQLGQQRDEETAVLLLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK08</accession>
    <name>A0A401QK08_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">Cloudy catshark</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01180442">
        <property type="protein sequence ID" value="GCB85663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK08"/>
    <dbReference type="OMA" id="GYEYEKM"/>
    <dbReference type="OrthoDB" id="6508505at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="8165" checksum="1102E353400EAA30" modified="2019-05-08" version="1" fragment="single">AIPGKQILVDTMIENHLNPKPYLGYEYEKMLSECNFSVISETRIRERCTNFVVELLKQLRQRLPDNVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKC5</accession>
    <name>A0A401QKC5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="13919" checksum="F933E1BAA4A5096F" modified="2019-05-08" version="1">MYYGDIPNVHHLVLEEAEYPAAPEPSGKIQLGISVSGILRFPATPTGRRLSRDNPIGQLPVPRILLLAGKRAAPEIRAGGKEYPGKSGLAGWGMPGNLDWRDGDSQEIKSGGKEDFGKSGLVGWGMLGNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKD4</accession>
    <name>A0A401QKD4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01189830">
        <property type="protein sequence ID" value="GCB85778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKD4"/>
    <dbReference type="STRING" id="75743.A0A401QKD4"/>
    <dbReference type="OMA" id="ERAGIWR"/>
    <dbReference type="OrthoDB" id="10611814at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="25550" checksum="FCD87510A953987F" modified="2019-05-08" version="1">MVGVQRDPGSSESRDLENVRTQREMEPTESRNWKEQRPGECRAQREQEPRESRDMREQEPGDSRDLERAGTWRVQGSGDSKDLERAGTWREQGSGESRDLERAETWREQGHGENRSQERTGTWREQGPGESRSPERTGTWREQGPGESRDLERAGIWREQGPGESGDRERAGAQRGQGPGESRDLERAGIWREQGPGESWDRERAGAQREQGPGESRDLERAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKD7</accession>
    <name>A0A401QKD7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01217432">
        <property type="protein sequence ID" value="GCB85836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKD7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="7298" checksum="BC1A98CD9A5AE442" modified="2019-05-08" version="1" fragment="single">SGITAAVSGYDLKCAAAVSGYDLKCAAAVSGYDLECAAAVSGYDLKCTVSVSGYDLECAAAVSGYDLECAAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLZ6</accession>
    <name>A0A401QLZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Menin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0027007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01269973">
        <property type="protein sequence ID" value="GCB86328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLZ6"/>
    <dbReference type="STRING" id="75743.A0A401QLZ6"/>
    <dbReference type="OMA" id="ACCFPRV"/>
    <dbReference type="OrthoDB" id="5962932at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007747">
        <property type="entry name" value="Menin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693:SF3">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05053">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB86328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="153" mass="16754" checksum="D0DF5952FD38DA7F" modified="2019-05-08" version="1" fragment="single">MGLKSAQAAFFPLCSIDEVVKLFASELARDDPDLTLLSLVLGFVEHFLAVNRVAPINVPGYSIEGPPPASSEAGSEPTAACCFPRVDLLQIRALHTRFTTMIRGAVDRSAYPPKGGVSSRELVKKISDVIWNNLSRSYFKDRAHIQSLFSFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMH6</accession>
    <name>A0A401QMH6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0027299</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01318843">
        <property type="protein sequence ID" value="GCB86631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMH6"/>
    <dbReference type="STRING" id="75743.A0A401QMH6"/>
    <dbReference type="OMA" id="FEHTADE"/>
    <dbReference type="OrthoDB" id="1733721at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB86631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="128" mass="14304" checksum="28F623B3383210F3" modified="2019-05-08" version="1">MADEKKPTSKPASKKGAKKVIKKPVVKGGKKRRRSRKASYSIYIYKVMKQVHPDTDISSKAMSIMNSFVSDIFEHTADEASRLAHYNKRRTISSREIQTAVHLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNV9</accession>
    <name>A0A401QNV9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentapeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01384316">
        <property type="protein sequence ID" value="GCB86983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNV9"/>
    <dbReference type="STRING" id="75743.A0A401QNV9"/>
    <dbReference type="OMA" id="NWADLTY"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485:SF1">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="20962" checksum="5ABDD0C8EE16D006" modified="2019-05-08" version="1" fragment="single">KATLNNAALNKAALNKAALNKAALNKANLNNATLNNAALNNAALNNAALNNAALNTAALNKAALNKADLNKAALNKAALNNAALNNAALNNAALNNAALNNAALNNAALNNAALNNAALNNAALNNAALNTAALNKAALNKAALNKAALNKAALNNAALNNAALNKATLNKATLNKATLNNVALNNAALNKAALNEAALNKAALNNAALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPF8</accession>
    <name>A0A401QPF8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0028040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01456002">
        <property type="protein sequence ID" value="GCB87309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPF8"/>
    <dbReference type="STRING" id="75743.A0A401QPF8"/>
    <dbReference type="OMA" id="MTQGERD"/>
    <dbReference type="OrthoDB" id="10066219at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="18669" checksum="ABEB2EE449F91064" modified="2019-05-08" version="1" fragment="single">KEQRDRGAKERRDSGVKERRDTRSEGAKSQRSEGAKRQRSEGSKSQRSDGANRQQSEGANRQRSEGAKRQRSEGAKSQWSEGAKSQRSEGVKRQRSERAKRQRSEEVKSQRSDGAKGQRSEETHGVRERRDSGAKERRDSGVKERRDSGVRERRDTRSEETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NG60</accession>
    <name>A0A401NG60_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004881">
        <property type="protein sequence ID" value="GCB59910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NG60"/>
    <dbReference type="STRING" id="75743.A0A401NG60"/>
    <dbReference type="OMA" id="TNEAMRE"/>
    <dbReference type="OrthoDB" id="346371at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042410">
        <property type="entry name" value="WBSCR13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44321">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44321:SF1">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019303006" evidence="6">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="398"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB59910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="443" mass="49382" checksum="32FA42CCA15C0FCE" modified="2019-05-08" version="1">MEPFVILAVSLLLGALIFFISAAVTGSRRAVPQDSNGSTVNEEDSKVSNGESDRNTASKKQKLQRPRKEKLQQHVFAHPLLATSLKSHSGNVSCLDFSSNGKYLASCADDRTVRIWSTKDFLEHDHRCVRANVELDHATHVCFSPDSRAFITWLANEETIRVFKMIKKDDGSFTFTAASEDFPKKHKAPIVNIGIAETGKFIMSASNDTTILIWDLKGELLATINTNQMNNAYATVSPCGRFVASCGFTPDVKVWEVCFTKSGTFREVLRAFDLKGHSAGIYSFAFSNDSRRMATVSKDGTWKLWDTDVEYKQQQDPYLLYTMKCNVSDPCRIALSPDARVVAISSGFSISVHSAKTGKQEEEFLNVHGEEIADLAFDINSRFLVSCGDRAIRIFHNVVGYRAVIEEMEGRLKKATNEAMRERLQQQVDDAQSALEAVCTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NG93</accession>
    <name>A0A401NG93_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006153">
        <property type="protein sequence ID" value="GCB59885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NG93"/>
    <dbReference type="STRING" id="75743.A0A401NG93"/>
    <dbReference type="OrthoDB" id="9997431at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF250">
        <property type="entry name" value="SYNAPTOTAGMIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="108"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="240"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB59885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="361" mass="40876" checksum="77811B34FD3AF4F2" modified="2019-05-08" version="1">MRHSKIVRMLQKFRVKKTTEPVQPRTRLTSPKIYGPKPVATSPEFINYADYALETTDDPLAADWVEADRSSLMMDSSEELFVVSKNAAVDATPLSPDLEGGLSENWTEAVKLHYAIKYNYQKSELHLTIVEAQYADTVENMNNCDTYVVGTLVTKLGKAEAETSNQTKSLYPLWQETLIFPVSAEHVQEGTLTLAIYSCNKYSRHNCVGEALLNLSDVAVDARTNSWINLKAPEKDSVTSPGEILLSINYLPAACRLIVVVMKARHLNSDKLKDLIDVSVKLTLMHQSLKLKKKHTGHVKHKINPVWNEMIMFEVPYELLSKSCLELEMLNQDCLKENLAQYSSKLFPIFCSLIEHKFMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NID4</accession>
    <name>A0A401NID4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004989">
        <property type="protein sequence ID" value="GCB60624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NID4"/>
    <dbReference type="STRING" id="75743.A0A401NID4"/>
    <dbReference type="OMA" id="FTESIEM"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097682">
        <property type="term" value="F:intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022832">
        <property type="term" value="F:voltage-gated channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075509">
        <property type="term" value="P:endocytosis involved in viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028798">
        <property type="entry name" value="TPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46768">
        <property type="entry name" value="TWO PORE CALCIUM CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46768:SF1">
        <property type="entry name" value="TWO PORE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="109"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="426"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="744" mass="85529" checksum="3D57904013F58328" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIJ2</accession>
    <name>A0A401NIJ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensin-2 complex subunit G2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006288">
        <property type="protein sequence ID" value="GCB60688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIJ2"/>
    <dbReference type="STRING" id="75743.A0A401NIJ2"/>
    <dbReference type="OMA" id="ETIENEC"/>
    <dbReference type="OrthoDB" id="10062843at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="119471" checksum="AC4A2F9F16A581CD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLN2</accession>
    <name>A0A401NLN2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ephrin type-B receptor 3</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">scyTo_0009400</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22 35">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01003831">
        <property type="protein sequence ID" value="GCB61793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLN2"/>
    <dbReference type="STRING" id="75743.A0A401NLN2"/>
    <dbReference type="OMA" id="DACYVVQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10478">
        <property type="entry name" value="EphR_LBD_B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05065">
        <property type="entry name" value="PTKc_EphR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09553">
        <property type="entry name" value="SAM_EPH-B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000041">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000015">
        <property type="entry name" value="Ephrin type-B receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000004">
        <property type="entry name" value="Ephrin type-B receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034245">
        <property type="entry name" value="EphB3_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF6">
        <property type="entry name" value="EPHRIN TYPE-B RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 24 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10 24 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="28" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019118432" description="Ephrin type-B receptor 3" evidence="28">
        <location>
            <begin position="17"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="32">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="31">
        <location>
            <begin position="318"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="31">
        <location>
            <begin position="429"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="615"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="30">
        <location>
            <begin position="907"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="23">
        <location>
            <position position="740"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="621"/>
            <end position="629"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 26">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="60"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="GCB61793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="980" mass="109054" checksum="E6037AAF8BE2295F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNL3</accession>
    <name>A0A401NNL3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps53 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0004257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001248">
        <property type="protein sequence ID" value="GCB62463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNL3"/>
    <dbReference type="STRING" id="75743.A0A401NNL3"/>
    <dbReference type="OMA" id="MINTADY"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="3">
        <location>
            <begin position="55"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="707" mass="80323" checksum="6B569F8C2988ABA5" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNX5</accession>
    <name>A0A401NNX5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EEF1A lysine methyltransferase 2</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methyltransferase-like protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein-lysine N-methyltransferase METTL10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EEF1AKMT2</name>
        <name evidence="7" type="synonym">METTL10</name>
        <name evidence="10" type="ORF">scyTo_0004267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:54193"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01001254">
        <property type="protein sequence ID" value="GCB62562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_072335354.1">
        <property type="nucleotide sequence ID" value="XM_072479253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNX5"/>
    <dbReference type="STRING" id="75743.A0A401NNX5"/>
    <dbReference type="GeneID" id="140393151"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000172">
        <property type="entry name" value="EEF1A lysine methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="80"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB62562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="26657" checksum="56E839D2F4981BD5" modified="2019-05-08" version="1">MEAAGYPHGCERQEKAIAQRQPPSNDEFQPSKLGTKEYWDHAYERELQSFYNSGDIGEIWFGEESMDRIITWLEMQNIPKDVALLDIGTGNGVFLIELAKSGFTNLTGIDNSSTAVELAKAIAEKEEVMSLKLQVADFLHSFPNLSQYDICIDKGTFDAISLSPDQPAENRSSYRQALHSVLKDGGLFLITCCNWTKEELVSHFSEGFEMLQELPTPKFQFGGKVGSSVTALVFKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPP6</accession>
    <name>A0A401NPP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-D-phosphohexomutase alpha/beta/alpha domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0014548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007846">
        <property type="protein sequence ID" value="GCB62836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPP6"/>
    <dbReference type="STRING" id="75743.A0A401NPP6"/>
    <dbReference type="OMA" id="ICHESIT"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047933">
        <property type="term" value="F:glucose-1,6-bisphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000017">
        <property type="entry name" value="glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF2">
        <property type="entry name" value="GLUCOSE 1,6-BISPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="4">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="5">
        <location>
            <begin position="71"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38080" checksum="69A1A86A5DE85451" modified="2019-05-08" version="1">MNLSIPEQKDPDPEFSTVKCPNPEEGECVLILAIKLAEKEGARVVLATDPDADRLAVAEQQEDDSWKVFSGNELGALLGWWMFKCWKDKHPDPTEVKNVYMLATTVSSKILHALAINEGFQFEETLPGFKWIGNRIDELLQSGNEVLFAFEESIGFLCGTLMFDKDGVSAAVIVAEIAAYLETRSLTITDQLNSIYRTYGYHISKTSYFKCYDPSTIKRIFDRLRNYESENQYPDCCGSFEILHIRDVTTGYDSSQPNKKSVLPVSRSSQMITFTFHNGCVATLRASGTEPKIKYYAEFCAPPGQSDTDHLAEELNKLIDAMVKDFLEPEKNCLITRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS53</accession>
    <name>A0A401NS53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DOPA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0013235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="9"/>
    <dbReference type="EMBL" id="BFAA01006684">
        <property type="protein sequence ID" value="GCB63705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS53"/>
    <dbReference type="STRING" id="75743.A0A401NS53"/>
    <dbReference type="OMA" id="FICATDI"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042423">
        <property type="term" value="P:catecholamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF167">
        <property type="entry name" value="AROMATIC-L-AMINO-ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB63705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="313" mass="34259" checksum="3D01AFA73F84BDDF" modified="2019-05-08" version="1">MVDYIIEYWETIEQRRAYPAVQPGYLRPLIPDSAPHEPESFADLMADIERVIMPGITHWQSPHFHAYFPAAISLPGFLGDMLCGGIGCVGFSWASSPACTELETVMLDWLGKMLNLPEDFLVEAGGEGGGVVQGSASESTLVALLAARKKMITQMQAKCPDLGEHTIMSKLVAYTSEEAHSSVERAGMIASIKMRKLPTDEKFCLRGETLRQALEEDKALGLIPFYFCATLGTTSSCAFDNIMELGPICNSENIWMHIDAAYAGSAFICPEFRPLLNELSLNGVVEISGSLIRMFAAIAELALGEQIERKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTP5</accession>
    <name>A0A401NTP5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004087">
        <property type="protein sequence ID" value="GCB64258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTP5"/>
    <dbReference type="STRING" id="75743.A0A401NTP5"/>
    <dbReference type="OMA" id="HAMSRMV"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47708">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47708:SF2">
        <property type="entry name" value="SI:CH73-132F6.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="212"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="326" mass="36379" checksum="B4878F4E31D00045" modified="2019-05-08" version="1">MLLFLFADIEGGAVRVQGARGLPPSDNYKVCATYLDGYRATAVCPVGGSRSVEKGRRTAESILKRMRRMFEQIGLDDFKTVNVQILGSEDTYGEQAVKRTDSPREAVIWLAVHHMQKKALELFSREIAPAGTGMAPGLTGIVGGRPKVSPVLKPFFFLHPKQNVTIDIFLNGKHAETFKEDFNYPHLPALEENIEQKEDDLKDLPNGPCSYRLEELAYTRSGDKGNSVNIGVIARHPLYYPYLRKAVTAQAVEEYFKHLIQKDSDRRMVTRFNLPGIQGLNFVLKDSLGGGGIASLRSDPQGKAYGQMLLDLRLNRLPDLKTLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUH6</accession>
    <name>A0A401NUH6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0000283</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000053">
        <property type="protein sequence ID" value="GCB64492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUH6"/>
    <dbReference type="STRING" id="75743.A0A401NUH6"/>
    <dbReference type="OMA" id="QVCICKK"/>
    <dbReference type="OrthoDB" id="9933746at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000095">
        <property type="entry name" value="Cadherin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000031">
        <property type="entry name" value="Cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF80">
        <property type="entry name" value="CADHERIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="181"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="287"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB64492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="415" mass="45337" checksum="0AC0C347DB1B2E36" modified="2019-05-08" version="1">MFYIDPEKGDIVTVVPPSILDRELLEAVKYELIVQAKDMTGSDVGLTGTATATIIIDDKNDHAPVFTKSMFQARVNEGFTGIIVNLTVEDNDDPATGAWRTVYTIINGNPDMNFKIETNPQNNDGMLFVDKSLDYERSAFHTLLIKVENEEPIMPEISYGSSSTTTVQVTVLDANEPPVFIPDPTIVVKPENIPIGSVVVTLNASDQDILQKQTIKFAQFQDPAGWLTINPADGTVTTRASLDRESPYVHDSQYTALFLATDNGVPVATGTGTLIITMLDVNDNPPSVFPTTAKFCEDSKDLNVAILGATDKDLHPNADPFKFQLGKQPGIEKTWKVTQVNSTHAQLRLLHTLKRANYILPIVVTDGGKPPLTNSTDVLVQICSCKKNKMDCSTANSLHISITLLLASIITLFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUK7</accession>
    <name>A0A401NUK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0009831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004116">
        <property type="protein sequence ID" value="GCB64565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUK7"/>
    <dbReference type="STRING" id="75743.A0A401NUK7"/>
    <dbReference type="OMA" id="KYAYMHH"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="13">
        <location>
            <begin position="361"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="12">
        <location>
            <begin position="610"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB64565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="725" mass="83072" checksum="31C8DEC16568D22B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV07</accession>
    <name>A0A401NV07_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006801">
        <property type="protein sequence ID" value="GCB64716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NV07"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="113" mass="12056" checksum="5672756DC4E01540" modified="2019-05-08" version="1">MHRGGGEVPVGAEHRHRQVQDAPATGRADEHVSLRHERLLHQAEGVGAHPAPEQEGQQGGDPATCHRLHLGLAARVGRSAGAGVSASRGKHGPEPGTPRCRCEWTDSRGFLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW87</accession>
    <name>A0A401NW87_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Frizzled-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">scyTo_0000380</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000070">
        <property type="protein sequence ID" value="GCB65127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW87"/>
    <dbReference type="STRING" id="75743.A0A401NW87"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15032">
        <property type="entry name" value="7tmF_FZD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000036">
        <property type="entry name" value="frizzled-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026543">
        <property type="entry name" value="FZD6_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF75">
        <property type="entry name" value="FRIZZLED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0807">Transducer</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="22">
        <location>
            <begin position="118"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="23">
        <location>
            <begin position="293"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="721"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GCB65127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="811" mass="91280" checksum="716C36003AAA5DD7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX67</accession>
    <name>A0A401NX67_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tumor suppressor candidate 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008173">
        <property type="protein sequence ID" value="GCB65445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX67"/>
    <dbReference type="OMA" id="FPVILWE"/>
    <dbReference type="OrthoDB" id="9025707at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029393">
        <property type="entry name" value="FUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15453">
        <property type="entry name" value="TUMOR SUPPRESSOR CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15453:SF8">
        <property type="entry name" value="TUMOR SUPPRESSOR CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15000">
        <property type="entry name" value="TUSC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12516" checksum="549DCF7C1EA578DC" modified="2019-05-08" version="1">MGGSSSKGRTFWPFGSGTVSDSANGDSEQSLARYRSSRLGATPFVFSRRSSMYYDEDGDLAHEFYEETFVTKNGRKKAKLKRIHKNLIPQGMVKLDHPRIHVDFPVVLCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXK0</accession>
    <name>A0A401NXK0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006903">
        <property type="protein sequence ID" value="GCB65602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXK0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="96" mass="11219" checksum="138B2A1C146487D9" modified="2019-05-08" version="1">MFEEKLVRPESNVHLHQIVGGHIEETRAIKQDNQIVGSNCEPIISFIDKIKMFGDWLKGFVKFHLTALFGMFYQFQLETVKPEKCLNPTRRRRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYB5</accession>
    <name>A0A401NYB5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005606">
        <property type="protein sequence ID" value="GCB65867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYB5"/>
    <dbReference type="STRING" id="75743.A0A401NYB5"/>
    <dbReference type="OMA" id="MEYHSRT"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045773">
        <property type="term" value="P:positive regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061003">
        <property type="term" value="P:positive regulation of dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098974">
        <property type="term" value="P:postsynaptic actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11960">
        <property type="entry name" value="SH3_Abp1_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000046">
        <property type="entry name" value="Drebrin-like protein isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035717">
        <property type="entry name" value="Drebrin-like_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB65867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="105" mass="11813" checksum="8C9BE5599DF63F99" modified="2019-05-08" version="1" fragment="single">LCQQVATREIVRVQDGTREQVHKDTGEQAVTEDTNVHQPVAETPYEGLCARALYDYQAADETEISFDPDDILTKIEQIDEGWWRGYAVDGSFGMFPANYVELLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYJ8</accession>
    <name>A0A401NYJ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protocadherin gamma-C3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0000508</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000095">
        <property type="protein sequence ID" value="GCB65947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYJ8"/>
    <dbReference type="STRING" id="75743.A0A401NYJ8"/>
    <dbReference type="OMA" id="NDWTRIQ"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000185">
        <property type="entry name" value="Protocadherin 2 alpha c"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF236">
        <property type="entry name" value="PROTOCADHERIN GAMMA-C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="188"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="247"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="356"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="472"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="569"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="693"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB65947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="817" mass="89945" checksum="8824B965AAC63EF7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYN2</accession>
    <name>A0A401NYN2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 179B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005614">
        <property type="protein sequence ID" value="GCB65977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYN2"/>
    <dbReference type="OMA" id="AQASLWC"/>
    <dbReference type="OrthoDB" id="6423876at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029673">
        <property type="entry name" value="TMEM179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25870" checksum="3C43F3F1707ECB9F" modified="2019-05-08" version="1">MGLGNRLLFCQCTAYLLAFVLSLFAAVPLGEDQHQLRGRCLLYGAGRWQQANGSGCAQAHCFHLLRWGPQAACCYSLFVAIFSCAYSALQGFRSTYLLCKSFQESLFSEFVSMLLSCTIALLMLVASATVSDGLNTWCNSVTNKGNTTISCRDAQEEPLNLNEVPTLFYDHFGTAQFGLWCAWIVWIVLAILAFLKISHSRCKDDFSVQYKETLLSQQSHGYFQRQVGSVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZZ6</accession>
    <name>A0A401NZZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-crystallin B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Beta-B1 crystallin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0013578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007004">
        <property type="protein sequence ID" value="GCB66492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZZ6"/>
    <dbReference type="STRING" id="75743.A0A401NZZ6"/>
    <dbReference type="OMA" id="NEWGALQ"/>
    <dbReference type="OrthoDB" id="5411518at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000005">
        <property type="entry name" value="Crystallin, beta B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000002">
        <property type="entry name" value="Crystallin, beta B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF12">
        <property type="entry name" value="BETA-CRYSTALLIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="9">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="9">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="9">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="9">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB66492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="227" mass="26519" checksum="A19FCE3D97795849" modified="2019-05-08" version="1">MSQATKSSTQEKGTPAAGPTPAAGSKGLKTREPGVGNFKIFIYEQENFQGRFMEFSTECMNLCDRNFDRVGSVRVDCGPWVAFEQANFRGEMFILEKGEYPRWDSWSNSYRSDRFMSFRPVCMDNQEHKICLFELAEFQGNKMEITEDDIPSLWAYGFCDRVGSVRVPSGTWVGYQYPGYRGYQYLFEMGDYKHWNDWCAQQPQMQSIRRLRDMQWHQKGCFQFATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P069</accession>
    <name>A0A401P069_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0000610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Forms either a homodimer or a heterodimer with a related family member.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the COE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000113">
        <property type="protein sequence ID" value="GCB66526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P069"/>
    <dbReference type="STRING" id="75743.A0A401P069"/>
    <dbReference type="OMA" id="FGSTTVW"/>
    <dbReference type="OrthoDB" id="25246at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11606">
        <property type="entry name" value="COE_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01175">
        <property type="entry name" value="IPT_COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4280:FF:000001">
        <property type="entry name" value="transcription factor COE1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3180:FF:000001">
        <property type="entry name" value="transcription factor COE1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001696">
        <property type="entry name" value="Transcription factor COE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038006">
        <property type="entry name" value="COE_IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018350">
        <property type="entry name" value="Transcription_factor_COE_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01345">
        <property type="entry name" value="COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IPT/TIG" evidence="14">
        <location>
            <begin position="253"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB66526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="583" mass="63498" checksum="2E60CDC2031BA0A9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1B7</accession>
    <name>A0A401P1B7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bardet-Biedl syndrome 5 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0007959</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell projection</location>
            <location evidence="1 10">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the BBS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002972">
        <property type="protein sequence ID" value="GCB66893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1B7"/>
    <dbReference type="STRING" id="75743.A0A401P1B7"/>
    <dbReference type="OMA" id="PNFGIQY"/>
    <dbReference type="OrthoDB" id="10261999at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00900">
        <property type="entry name" value="PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000232">
        <property type="entry name" value="Bardet-Biedl syndrome 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006606">
        <property type="entry name" value="BBL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030804">
        <property type="entry name" value="BBS5/fem-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014003">
        <property type="entry name" value="BBS5_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351">
        <property type="entry name" value="BARDET-BIEDL SYNDROME PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07289">
        <property type="entry name" value="BBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010072">
        <property type="entry name" value="DUF1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00683">
        <property type="entry name" value="DM16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="11">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="11">
        <location>
            <begin position="159"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB66893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="342" mass="38975" checksum="0AA7A299D7460077" modified="2019-05-08" version="1">MVPVLDALWEDRDVRFDISLQQMKMRSGEALIDCLDSIEDTKGNNGDKGRLLVTNLRIIWHSLALPRVNLSVGYNCIINITTRTANSKLRGQTEAVYILTKCNNTRFEFIFTSVVPGSPRLFTTVIAVHRAYETSKIYRDLKLRGALIQNKQLRLLPQEQVYDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNDSFNVSIPYLQIRSIKIRDSKFGLALVIESSQQSGGYVLGFKIDPVEKLQEAVKEINSLHKVYSACPIFGVQYEMEEKPQPLEDLTVEQVQDDVEIEPEEQTDAFVAYFADTNKQQDREPVYSEELGIAIEKLKDGFTLQGLWEVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1K3</accession>
    <name>A0A401P1K3_SCYTO</name>
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        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA-templated DNA replication"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Taq DNA Polymerase, Chain T, domain 4"/>
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    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_61"/>
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    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
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    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF62">
        <property type="entry name" value="DNA POLYMERASE THETA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="7">
        <location>
            <begin position="1515"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1352"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="920"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1354"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB66980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1794" mass="198305" checksum="33498898DABB3825" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P224</accession>
    <name>A0A401P224_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004354">
        <property type="protein sequence ID" value="GCB67178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P224"/>
    <dbReference type="STRING" id="75743.A0A401P224"/>
    <dbReference type="OMA" id="SQHKRYE"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF30">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="791" mass="89450" checksum="83373BE40D25FE65" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P295</accession>
    <name>A0A401P295_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="15">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0012123</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-2,3-epoxysqualene = lanosterol</text>
            <dbReference type="Rhea" id="RHEA:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="EC" id="5.4.99.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01005753">
        <property type="protein sequence ID" value="GCB67258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P295"/>
    <dbReference type="STRING" id="75743.A0A401P295"/>
    <dbReference type="OMA" id="WVHIRQV"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000084">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019208955" description="Terpene cyclase/mutase family member" evidence="16">
        <location>
            <begin position="18"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="18">
        <location>
            <begin position="110"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="17">
        <location>
            <begin position="411"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB67258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="761" mass="86718" checksum="1656799B2CF5A0D4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P377</accession>
    <name>A0A401P377_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005789">
        <property type="protein sequence ID" value="GCB67599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P377"/>
    <dbReference type="STRING" id="75743.A0A401P377"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="65" mass="7039" checksum="788D3852F7991D4B" modified="2019-05-08" version="1" fragment="single">TSPPAEPNSQTPPELSPTDLEKSDVQPSGVKENTETTKDTQESEDGEPLPKKIRTETSQQSAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3B1</accession>
    <name>A0A401P3B1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004392">
        <property type="protein sequence ID" value="GCB67612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3B1"/>
    <dbReference type="STRING" id="75743.A0A401P3B1"/>
    <dbReference type="OMA" id="GDWTKRN"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB67612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="164" mass="18428" checksum="E5295EDDA0ECED25" modified="2019-05-08" version="1">MRIQGSDFVLVSSDRVAASSIVAMKHDYDKMFKLSEKILLLCVGEAGVTVQFAEYIQKNVQLYKMRNGNELSPSAAANFTRKTLAEYLRSRTPSHVNMLLAGCDEQEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYKPDLTREEAVELLKKLKNDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3U0</accession>
    <name>A0A401P3U0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0012189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005810">
        <property type="protein sequence ID" value="GCB67781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3U0"/>
    <dbReference type="STRING" id="75743.A0A401P3U0"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB67781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22097" checksum="0EDE21F7DB7B5C86" modified="2019-05-08" version="1">MQALLNESGDSEDVRQPFIQPNLETQTRMRMALPVAVKVTLALFAANIFDGENYVVHVVASPQWLASGPGHSVGGELHCRHSLWPRLGSNLHEIDAVLYSIAEKVKYIAIIYLVDITEVPDFNKVYELYDPCTVMFFFRNKHIMIDLGTGNNNTINWPMEDKQEMIDIVEIVYRGAHKGRGLVVSPKACHDMHSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3W8</accession>
    <name>A0A401P3W8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0005205</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001595">
        <property type="protein sequence ID" value="GCB67811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3W8"/>
    <dbReference type="STRING" id="75743.A0A401P3W8"/>
    <dbReference type="OMA" id="QHAEPDG"/>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF197">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12 16 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="18">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="14 17">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16 17">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB67811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="736" mass="81977" checksum="73A1695BBA47A785" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4B4</accession>
    <name>A0A401P4B4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bridge-like lipid transfer protein family member 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0013758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007167">
        <property type="protein sequence ID" value="GCB67963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4B4"/>
    <dbReference type="STRING" id="75743.A0A401P4B4"/>
    <dbReference type="OMA" id="MHIIKGS"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 N-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="770" mass="88339" checksum="C9F224A83FEA5A47" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5H1</accession>
    <name>A0A401P5H1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0013818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007213">
        <property type="protein sequence ID" value="GCB68379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5H1"/>
    <dbReference type="STRING" id="75743.A0A401P5H1"/>
    <dbReference type="OMA" id="HDWLLME"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB68379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="413" mass="45843" checksum="4F40BA781B4E15E2" modified="2019-05-08" version="1">MGQSQSGGHGAGSGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLTDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFQIHTSRMTVAQDVSLDELILAKDDLSGADIKASGVVFFLPMCFSSALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P657</accession>
    <name>A0A401P657_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0013850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007241">
        <property type="protein sequence ID" value="GCB68614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P657"/>
    <dbReference type="STRING" id="75743.A0A401P657"/>
    <dbReference type="OMA" id="EKSICAP"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB68614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="472" mass="54120" checksum="C8F5887A76C8C624" modified="2019-05-08" version="1" fragment="single">ARNAIQKQLEKNKMLTTKVLVPSESEDEVEAEVDRDDAVPDFVNDIEANMVANPWMLGRLTTDAKSSETQEQEIATLVDGNDESDDGEKLSEDEKLLQEFEERRRIRKERDGELAGSSVIVDQSKDEEMVKNNDEGKESTVPDDQGEKEEHLEEDLNEFNHLFQKLIQSKSEPTSRNPKKTRRKNKKMGTKEIKEDEMVPEVWEEPILDEQLERKRTMEEYETLGQDECRDLGEASALDTPQIIGNPADSENKSNTKTEVKKKQLINPKNVLMVTSKSIEMPLVPTAIREENEEQEDQRMVVQEAFASDDVIDDFIKDKKRQIDAGKPKDIDLTLPGWGEWGGQGLQPSAKKRRRFRIKAAPPPLRKDQHLPNVIISEKRDIGIAEHQVNQLPFPFSHRNQFEKSICAPIGNTWNTERATQKLTMPKIVTKMGTIIAPISEDDLLQDKKSRTEKVRQNPHQHRKVQKKKPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P810</accession>
    <name>A0A401P810_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0008354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003176">
        <property type="protein sequence ID" value="GCB69244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P810"/>
    <dbReference type="STRING" id="75743.A0A401P810"/>
    <dbReference type="OMA" id="EIMTITH"/>
    <dbReference type="OrthoDB" id="74247at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000030">
        <property type="entry name" value="NATD1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB69244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="120" mass="14104" checksum="1C2491CEC6049487" modified="2019-05-08" version="1">MAESNAIPVQDENNCPIKVDHDRKRRQFEVRLNGSHERAVLLYDYVGKKTIDLQHTEVPDAYRGRGIAKLMAKAALDFVVEEDLRAHLTCWYLQKYIKENPLPHYVERIQQRAPTDFQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P828</accession>
    <name>A0A401P828_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline-rich protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005977">
        <property type="protein sequence ID" value="GCB69264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P828"/>
    <dbReference type="OMA" id="DAPMHIT"/>
    <dbReference type="OrthoDB" id="10066480at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330">
        <property type="entry name" value="P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330:SF9">
        <property type="entry name" value="PROLINE-RICH PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45887" checksum="8F70F6D0B77E5033" modified="2019-05-08" version="1">MPKLSQRHRKWKTMRKRQAMEKAWNDSKQRLLTKNKRNVCKAKPITAETAGKKEIPASISNFSQHECVPNRLTSLVNVKNMLNPLKAAISSLYNWWLNSIGQGLDVVKDILFPSRVYLRELNALRQHMEILEMELTQLHKIVNVNLVSNNAKAADTCSCRKYIDFSPSPAKIPVWPVQPIISCRMLLEPFGALPPPPPPPPPPLPPPSVFVQKPLQILRKSRSDHSLQTLSEEIGRLPSITMKDLLKVKLKKTADRFELKKTVPERMDGPLPVTVKDLLEVKLRKTQNKLEEPEINMPEKERSPLVTISDLQGFNLRAKANRLPRSAKILTTLNKPVVDLRQRLKKVAIERSPGGTPLYKENRDTGTGLTPVMTQALKRKFEMAHPKSSPCCLSPNTSFDDQITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P833</accession>
    <name>A0A401P833_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho guanine nucleotide exchange factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0005449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001694">
        <property type="protein sequence ID" value="GCB69272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P833"/>
    <dbReference type="STRING" id="75743.A0A401P833"/>
    <dbReference type="OMA" id="HQNDKCD"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000025">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000206">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000434">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="46"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB69272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114598" checksum="43B47BCEE435A1A5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAB8</accession>
    <name>A0A401PAB8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0010692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004662">
        <property type="protein sequence ID" value="GCB70069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAB8"/>
    <dbReference type="STRING" id="75743.A0A401PAB8"/>
    <dbReference type="OMA" id="IQAQHND"/>
    <dbReference type="OrthoDB" id="75950at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="8">
        <location>
            <begin position="155"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="204"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="412"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB70069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="515" mass="61733" checksum="D32B7CFFFBEFDD68" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAS3</accession>
    <name>A0A401PAS3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004682">
        <property type="protein sequence ID" value="GCB70222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAS3"/>
    <dbReference type="OrthoDB" id="9450584at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029395">
        <property type="entry name" value="DUF4514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37857">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37857:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14986">
        <property type="entry name" value="DUF4514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="8976" checksum="79C399F23E07AD85" modified="2019-05-08" version="1">MEIGGYFTTRASANGAAKNEDEIELKYALLGGGIGIFLVISFVVVKICMIRKHIYENELTDTPSRQSQSLREERNRIAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCB1</accession>
    <name>A0A401PCB1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhombotin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">LIM domain only protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001847">
        <property type="protein sequence ID" value="GCB70760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCB1"/>
    <dbReference type="STRING" id="75743.A0A401PCB1"/>
    <dbReference type="OMA" id="MCGGCQQ"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09384">
        <property type="entry name" value="LIM1_LMO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09385">
        <property type="entry name" value="LIM2_LMO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000059">
        <property type="entry name" value="LIM domain only 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF3">
        <property type="entry name" value="RHOMBOTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB70760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="188" mass="21650" checksum="A05546C8CEB004C3" modified="2019-05-08" version="1">MKKSPSSFGALQSCCRPGDAESQRCRLPEQMSAAIERKSLENAEEPVDEVLQIPPSLLNCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCSACDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKLNGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDM3</accession>
    <name>A0A401PDM3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0001497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000338">
        <property type="protein sequence ID" value="GCB71223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDM3"/>
    <dbReference type="STRING" id="75743.A0A401PDM3"/>
    <dbReference type="OMA" id="TGWQALW"/>
    <dbReference type="OrthoDB" id="5978115at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057508">
        <property type="entry name" value="SHCBP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045140">
        <property type="entry name" value="SHCBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14695:SF8">
        <property type="entry name" value="SHC SH2 DOMAIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14695">
        <property type="entry name" value="SHC SH2-DOMAIN BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23762">
        <property type="entry name" value="SHCBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHC SH2" evidence="5">
        <location>
            <begin position="89"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="4">
        <location>
            <begin position="444"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB71223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="697" mass="77924" checksum="360D2FE7B3A3C742" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDW5</accession>
    <name>A0A401PDW5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001912">
        <property type="protein sequence ID" value="GCB71317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDW5"/>
    <dbReference type="OrthoDB" id="8443315at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016321">
        <property type="term" value="P:female meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010789">
        <property type="term" value="P:meiotic sister chromatid cohesion involved in meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034545">
        <property type="entry name" value="Meikin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38006">
        <property type="entry name" value="MEIOSIS-SPECIFIC KINETOCHORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38006:SF1">
        <property type="entry name" value="MEIOSIS-SPECIFIC KINETOCHORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="252" mass="27631" checksum="D76DA6DE1702CC7C" modified="2019-05-08" version="1">MNQCSSLAHGKRNAKPSSKLKKLSFIKEETDSHIAPTNSLASGAHGSLHLFRMKRTARRNILKTKKGIEPFRNRSPSLQQWKKFTQSKSKSTCSECTETTSELSPYLSPSVDSELLMDDDSSTRTDSCSSIELFREAEDHTSVVNQEGICWFSCKNSTLLDSSGAANIDVIGQPSGLSEILEQTENPAIEGSFKSDHVSDGAEVHGKSQTISFTVAGKTVSKLQASKEATLEQKGVHTISLPREQKILVREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFF1</accession>
    <name>A0A401PFF1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0006079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001988">
        <property type="protein sequence ID" value="GCB71824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFF1"/>
    <dbReference type="STRING" id="75743.A0A401PFF1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000566">
        <property type="entry name" value="zinc finger protein 133 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB71824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="164" mass="18196" checksum="F8881F935D0D2555" modified="2019-05-08" version="1">MCDKSFSKSSALREHQRIHTREKPFTCQVCDRSFTQSSTLHKHRRTHTGEKPILCKVKLARNTQERSLTGGQIPYTKELTEQEEFTRKLFGLPNPTITNGGSDMVMSEDTQVSVNTSDGDRGELTAVSEIPERADEEGTEVNTSQQCGMAAAVEEGEKCQEGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFU5</accession>
    <name>A0A401PFU5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000414">
        <property type="protein sequence ID" value="GCB71996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFU5"/>
    <dbReference type="STRING" id="75743.A0A401PFU5"/>
    <dbReference type="OMA" id="PENWHIR"/>
    <dbReference type="OrthoDB" id="9948558at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF2">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="223"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="370" mass="43036" checksum="4BDC7B25D69CC3AD" modified="2019-05-08" version="1">MFLYLGIDNRAVRWKILRKVLAVVENERHLPENWHIRAQTARFHSDTVYLIYDPVDIHLAHLLRNELQKKGLQVLTFDNLDQSMKEFLRITAPKIATAKKIVVLLTEEAAVSPFVYHQVLFSEWLGRPIATAMFRNMWKRFRPSLRVILGDKPAVAFERQLFENALDILTHQLRPRPRVTGIIFEQAYLNWVAEGVKPLKVLATSSPASILWPFDSDEVQPKVFISYQWDVQSKVQKIRNYLEANGLPCWADLSVRGQSQMSTRSSFAFDLATETLQGQIQRNMKVAHAVVSCLTLRYIQSDNYIKDVQLAETLQKPLVPVLFQLLRWPPKGTSIKMRRFLFNFPVIDLSNDRLFHQNLDLILKRLNQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHT2</accession>
    <name>A0A401PHT2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002161">
        <property type="protein sequence ID" value="GCB72690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHT2"/>
    <dbReference type="STRING" id="75743.A0A401PHT2"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB72690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8259" checksum="DC544D34C081501E" modified="2019-05-08" version="1">MAATELPELKELNVQEVNVSSAVLKAAAHHYGSQCDKPNKEFMLCRWEEKDPRKCLQEGRKVNECALDFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJF6</accession>
    <name>A0A401PJF6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOCKER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0002421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000609">
        <property type="protein sequence ID" value="GCB73231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJF6"/>
    <dbReference type="STRING" id="75743.A0A401PJF6"/>
    <dbReference type="OMA" id="MINQHHS"/>
    <dbReference type="OrthoDB" id="9631652at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF6">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="3">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="474" mass="52580" checksum="BFCE81A509DFEBF5" modified="2019-05-08" version="1">MKTTSSPGDEIKNSPGQFVQCFTVQPILAEQQQFRNKNVPEQIMGFFKANNVLKFSYSRPIRRGPKDPENEFASMWIERTTFTTAYKMPGILRWFEVVQTSLTYVSPLENAIETMQSSNDKILTMINQHHSDPNLSINPLSMLLNGTVDPAVMGGFAKYETAFFTEKYMSEHPEDMDNITKLKDLIAWQIPLLDEGIRVHGKKVTEALKPFHDRMVECFAQLKTKVENQYGIRDLSFFEERRGGGGGGGGGGGSRPRSMIRSFRPLSVISSSSLSSASSDKETSRVSVDSAEPPLPKKQISRSQEKPPDSGMKEIEEKRLTRRENRISGLFASRKSSVSAPTPPPDVDEEPSRLSQLVSDTRMVESHPDPEQPAKERSPSLSGQTFSSINGFSGRIKSARPPPLPRKINPSLLESFSQDQGDPLLSPPVHQGSAMEQFQNKAACPATPDDSKTLKSPPPPPPPKNKRVAPHSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLK9</accession>
    <name>A0A401PLK9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000813">
        <property type="protein sequence ID" value="GCB73993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLK9"/>
    <dbReference type="STRING" id="75743.A0A401PLK9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000494">
        <property type="entry name" value="serine/threonine-protein kinase WNK2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26047" checksum="28B749142366C497" modified="2019-05-08" version="1">MEPRESGKPGLTEITAAEGSDNGGSGGDDAAGGVVSAVGAAAGNGPECDEGGPEAAAAHTGSCGNMDSAAVMMRRRRAAAPGLNPLGQDYPRHTQRFVRRIVPLSVPLSVPPPVSAERPSRLLQNGAEPEPPQSVALRALRGEAAAEGSSTESQAGKKGSATESVSADEEKDGKAGESAAREPAESPKDLTKSKSEENEEEAEMKAVATSPDGRFLKFDIELGRGSFKTVYKGLDTETWLEVAWCELQVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLQ6</accession>
    <name>A0A401PLQ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin Y-type LIR-motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0003105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000823">
        <property type="protein sequence ID" value="GCB74021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLQ6"/>
    <dbReference type="STRING" id="75743.A0A401PLQ6"/>
    <dbReference type="OMA" id="HTSTLMY"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
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            <dbReference type="PubMed" id="30297745"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
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                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2670"/>
            <end position="2685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2884" mass="316950" checksum="0CD5F2880A354FFF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNQ0</accession>
    <name>A0A401PNQ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0003826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01001073">
        <property type="protein sequence ID" value="GCB74735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNQ0"/>
    <dbReference type="STRING" id="75743.A0A401PNQ0"/>
    <dbReference type="OMA" id="RYLTIRY"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008459">
        <property type="term" value="F:chondroitin 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF5">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="13">
        <location>
            <begin position="228"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB74735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="409" mass="46560" checksum="5182DC5CD993AED9" modified="2019-05-08" version="1">MKLLQSRCLIVILVYSLLLLAIPYFLDCRNKMLAPGEQPFLRECSEVVAPMSWGEEDLDTGGNLTVGARRSRQHIYIHATWRTGSSFAGELFNQHPAVFYLYEPMWLMWQVLYPGDAESLQGAVRDMLRSLFRCDFSVLRLYSAAGPLTTRAVFGWKNNKVICSAPLCGAYRKERVELVDGGVCEKQCAARDIGELERECRKYEVMVIKDVRVLDVGVLFPLMGDPSLNLKVVQLVRDPRAVHNSRMKSKQSLVKESIQVLRSKHRLERTRWPLLSNRAQRADSSVARALEVICEAWSRDQELVRRSPAWLRARYLTIRYEDLVLEPLSGLGALYSFANLTVTPATEAYMLNMTRGVGYSSDRPFLISSRDAKEAVSAWKKRLSLGQVQQVEQSCQRAMRALGYRPNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNU3</accession>
    <name>A0A401PNU3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0003869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001090">
        <property type="protein sequence ID" value="GCB74778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNU3"/>
    <dbReference type="STRING" id="75743.A0A401PNU3"/>
    <dbReference type="OMA" id="ISHHECD"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF26">
        <property type="entry name" value="V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB74778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="180" mass="20452" checksum="741A88D844FBD395" modified="2019-05-08" version="1">MLLIKPYLLYSDQQRAKLKVLMCDSSEVSILQQEHAETEINGGRDKSHWEEEKFSFGDTFVQQAIHTIEYCLGCVSNTASYLRLWALSLAHAELSEVLWHMVLHNGFTANKGLSSIGLTITFAAFAVLSVAILLVMEGLSAFLHALRLHWVEFQNKFYKGAGYKFIPFSFTDICKRKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP21</accession>
    <name>A0A401PP21_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Parvalbumin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0020284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the parvalbumin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016168">
        <property type="protein sequence ID" value="GCB74900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008080">
        <property type="entry name" value="Parvalbumin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653:SF10">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653">
        <property type="entry name" value="PARVALBUMIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        </ligand>
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        <location>
            <position position="100"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608080-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB74900.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="13076" checksum="9E83BFEF0BF4A074" modified="2019-05-08" version="1" fragment="single">ELKSVISFTMKILDILGAGDINSAISECKALDSFDFKKFFGTCGLSKKSMEDLRKVFAILDQDGSGSIDKTELKLFLQYFSTDARVLSDKEAQSMLSAADNDGDGKIGFEEFQRLVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR10</accession>
    <name>A0A401PR10_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013782">
        <property type="protein sequence ID" value="GCB75553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="40" mass="4267" checksum="2C6C6187196B2487" modified="2019-05-08" version="1" fragment="single">LKSRVHVTVGIVLGVLGIIALAVVAVVIYRKKVTSRVPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRA6</accession>
    <name>A0A401PRA6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UMOD/GP2/OIT3-like D8C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0016460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009948">
        <property type="protein sequence ID" value="GCB75666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRA6"/>
    <dbReference type="STRING" id="75743.A0A401PRA6"/>
    <dbReference type="OMA" id="MINVEVH"/>
    <dbReference type="OrthoDB" id="2015116at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36191">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36191:SF4">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019233905" description="UMOD/GP2/OIT3-like D8C domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="UMOD/GP2/OIT3-like D8C" evidence="5">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB75666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="228" mass="25484" checksum="15949812AAF37D49" modified="2019-05-08" version="1">MRSLILLLGCLVTESTLTDPCGNYTVLEQPWRSTDCKDTDCSGQWMCDTRLGKAWYRLKSSGGWKIPEHVVPKRRCSTDFTIWLNGSHPTVGQGEVTKTVCFHGKTDCSYTLEINIKNCTDYIVYELKPPPHCQSAYCTDPETADALGLNDHSTQQSTDPDSLSPTPSPKTDTQYKMINVEVHSKMKVDDETAKGIVLKRLQQMTDEQCPGKSIDLNQVDVQCSDVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRD9</accession>
    <name>A0A401PRD9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009950">
        <property type="protein sequence ID" value="GCB75683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRD9"/>
    <dbReference type="STRING" id="75743.A0A401PRD9"/>
    <dbReference type="OMA" id="ASHMENE"/>
    <dbReference type="OrthoDB" id="304622at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026704">
        <property type="entry name" value="KATNIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534:SF0">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="453" mass="51495" checksum="06EAAAC72FA5BD6C" modified="2019-05-08" version="1" fragment="single">MKGHCFREHSAQLKTEKVSLKEWGETVGVNKADQNVLMDFDEKHDQYLILLQYRNRILKRLKAKDPKKIQLERLEQGFSIYVNGANSELKRQPKIEAASRSVHTADSAARPTLYLEELQEFDVTKRRTQTAPSKVHRKGWVQSSVHIKTEKGAQLHLGPPVDYSDDFEAYESVNMETEDIPCNCSQILADDSSRNRGNSCFLPKSSFIKPGRISDKSCCEGNDKILLNMQDVKMLRRSLTQTAELQLNSEKSIDSEDSDSLEDEKIGEQIEPENLEDLQLNKLSFQKGSEAKQYSLHPGDLIVLDFGPGTKSKRKERILTVTRKDDVECYIPVKPTMVKSKSFDRFASPNQDGTDLISNQECRQERILSAVRRNIFQVKDPELSASSVFQAMQKENEDVLNSVEKQRTIKTPLCWQMLSPSELAVNGTLQCSPGSAKHNKIDKAIERISYLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS86</accession>
    <name>A0A401PS86_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Hsp90 co-chaperone Cdc37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0020425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with Hsp90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016470">
        <property type="protein sequence ID" value="GCB75980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS86"/>
    <dbReference type="STRING" id="75743.A0A401PS86"/>
    <dbReference type="OMA" id="NWCIDLE"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF3">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="102"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB75980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="357" mass="41525" checksum="D6905B1C24EA7972" modified="2019-05-08" version="1">MLLISKSTTCYLLQARVERMEEAQKEREEYEKACGDCQRKLGECQKKLKDLMLLGTDDAKKDIEKLQAEVKQLKKEEKDWDKKGTSLKKKEKSMPWNVDTLSKEGFSKSVINAAPESSKAETEEDKEKKHRTFVEKYEKQIKHFGMLSHWDDSQKHLSDNPHLVSEETANYLVIWCIDLEVEEKHALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADKQYIEAFNDELGAFKERVKGRAQARIEKAMKEYEEEERQKRLGPGGLDPVEVYESLPVEMKNCFDSKDIQMLQDVISKLEPTDAKYYMQRCIDSGLWIPNAKAAEEEGEKSAEDEDPVYEEVKKESSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSD3</accession>
    <name>A0A401PSD3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dehydrogenase/reductase SDR family member 6</fullName>
            <ecNumber evidence="6">1.1.1.104</ecNumber>
            <ecNumber evidence="7">1.1.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">(R)-beta-hydroxybutyrate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">3-hydroxybutyrate dehydrogenase type 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">4-oxo-L-proline reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Oxidoreductase UCPA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Short chain dehydrogenase/reductase family 15C member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0020969</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20521"/>
            <dbReference type="ChEBI" id="CHEBI:10983"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.104" evidence="6"/>
    <dbReference type="EC" id="1.1.1.30" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01017767">
        <property type="protein sequence ID" value="GCB76018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSD3"/>
    <dbReference type="STRING" id="75743.A0A401PSD3"/>
    <dbReference type="OMA" id="VASSIKX"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003858">
        <property type="term" value="F:3-hydroxybutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016617">
        <property type="term" value="F:4-oxoproline reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB76018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="14376" checksum="06BB66AD32CA4B8E" modified="2019-05-08" version="1" fragment="single">FVHHGTILECEDKDWDFTMNLNVRSMYLMIRTFLPKMLAQNSGNIINMSSVVSSIKGVVNRCAYGTSKAAVIGLTKSVAADFIEQGIRCNCVCPGTVDTPSLRGRIQAQPNPQQSTYVTGKEFIIDGGWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT18</accession>
    <name>A0A401PT18_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3</fullName>
            <ecNumber evidence="14">2.4.1.102</ecNumber>
            <ecNumber evidence="13">2.4.1.148</ecNumber>
            <ecNumber evidence="12">2.4.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">C2GnT-mucin type</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0015450</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-[N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56188"/>
            <dbReference type="Rhea" id="RHEA-COMP:11691"/>
            <dbReference type="Rhea" id="RHEA-COMP:14412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:87079"/>
            <dbReference type="ChEBI" id="CHEBI:139581"/>
            <dbReference type="EC" id="2.4.1.148"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 3-O-[N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56192"/>
            <dbReference type="Rhea" id="RHEA-COMP:11692"/>
            <dbReference type="Rhea" id="RHEA-COMP:14413"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:87080"/>
            <dbReference type="ChEBI" id="CHEBI:139580"/>
            <dbReference type="EC" id="2.4.1.148"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 3-O-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56212"/>
            <dbReference type="Rhea" id="RHEA-COMP:13922"/>
            <dbReference type="Rhea" id="RHEA-COMP:14419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137949"/>
            <dbReference type="ChEBI" id="CHEBI:139605"/>
            <dbReference type="EC" id="2.4.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 3-O-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = a 3-O-{beta-D-galactosyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56216"/>
            <dbReference type="Rhea" id="RHEA-COMP:13923"/>
            <dbReference type="Rhea" id="RHEA-COMP:14420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137950"/>
            <dbReference type="ChEBI" id="CHEBI:139607"/>
            <dbReference type="EC" id="2.4.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;6)]-beta-D-Gal-(1-&gt;4)-N-acetyl-beta-D-GlcNAc derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54820"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:138371"/>
            <dbReference type="ChEBI" id="CHEBI:138372"/>
            <dbReference type="EC" id="2.4.1.150"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.102" evidence="14"/>
    <dbReference type="EC" id="2.4.1.148" evidence="13"/>
    <dbReference type="EC" id="2.4.1.150" evidence="12"/>
    <dbReference type="EMBL" id="BFAA01008771">
        <property type="protein sequence ID" value="GCB76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT18"/>
    <dbReference type="STRING" id="75743.A0A401PT18"/>
    <dbReference type="OMA" id="WEYHFEL"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047225">
        <property type="term" value="F:acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003829">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008109">
        <property type="term" value="F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF81">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00055416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB76223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="409" mass="47046" checksum="DC70FF7D0B6EB202" modified="2019-05-08" version="1">MAILGGYFFRKQDLPVNYWIAGKGKSGDCARYESLGLSSENSSCWEIIRGDYEAIGKSLLKSIEIANKYKVFTEIDYLMKARDCGIFVKNRKYITFPLSAEERNFPLAYSMVIHGNIEMFERLLRSIYAPQNVYCVHVDRKSPKPFRSAVEAIASCFNNVFIACKSESVIYASWSRVQADLNCMEELLQSPVPWRYLINVCGQDLPTRTNREIVKSLMAQNGTNVIESDIPPTYKKKRWKFHYDVHEYVALTNQQKERPPIRSSMFVGSAYVLVTREFVRHLFVTAEIQAFFKWSQDTYSPDEHIWATLQRMPGVPGSIPHVPGRPRIIARVVKWSFEAGDMAKGALYPPCTGKYHHLICTYGTGDLHWIVQREPWFANKFDPGVDNIAVQCMEEHLRHRAIRGACRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTB0</accession>
    <name>A0A401PTB0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016566">
        <property type="protein sequence ID" value="GCB76386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTB0"/>
    <dbReference type="STRING" id="75743.A0A401PTB0"/>
    <dbReference type="OrthoDB" id="10064508at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120147">
        <property type="term" value="F:formylglycine-generating oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051043">
        <property type="entry name" value="Sulfatase_Mod_Factor_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150:SF26">
        <property type="entry name" value="GENERIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150">
        <property type="entry name" value="SULFATASE MODIFYING FACTOR 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="206" mass="24019" checksum="0B64B8C90F8EE969" modified="2019-05-08" version="1">MKSVLTGKLCLTSLKPCNLGKCTKEEVLEYFENTYDLDETIFSALKDESSFYLCPDRLRLPLIFYYCHPSVVYINKLLIAGLIKEQVNPRFETLFETGVDEMSWDDTENYRMGGSFNWPRLLECVEYRRKVRAIVRKVIQETPLELPVTVDNPWWAIFMGLEHERIHLETSSVLIRQMPIHLLQRPPSWKYASSNIGQCICLSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTD3</accession>
    <name>A0A401PTD3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015268">
        <property type="protein sequence ID" value="GCB76394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTD3"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="203" mass="21816" checksum="34A5FE4FE31A591F" modified="2019-05-08" version="1">MNNHLPGELGRVTTAGDLEYRIPDPDDQAQEERCHRNGDEITANRNDITAHGADITTHDNANTTHGNYITAYGNAVTTYGADITTHGNDITAHGADIMTHGDGITAHGGDTIAHGDDITTHGNDITTHEDDITSHGDDIITQGNDITTQGGDITTLGNDITTKLKTYCLRLLHQICSQFESSLCGHLSVCWKNWPLSTASLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTN9</accession>
    <name>A0A401PTN9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0021010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017884">
        <property type="protein sequence ID" value="GCB76509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTN9"/>
    <dbReference type="STRING" id="75743.A0A401PTN9"/>
    <dbReference type="OMA" id="ECVFESE"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB76509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19261" checksum="6E9F3DBE0CE70574" modified="2019-05-08" version="1">MLLGYLAVSCVLFLAARWAFTLIIISSYTANLAAFLTVQRMEVPIESADDLADQTNIGYGTIQGGSTMTFFQNSRYQTYQRMWNYMHSKQPSVFVKTTEEGIARLLNSKYAFLLESTMNEYHRKRNCNLTQIGGLLDTKGYGIGMPLASVWVYESECVFESECVFESECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTS2</accession>
    <name>A0A401PTS2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008823">
        <property type="protein sequence ID" value="GCB76530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTS2"/>
    <dbReference type="STRING" id="75743.A0A401PTS2"/>
    <dbReference type="OMA" id="DYCLFLD"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20563">
        <property type="entry name" value="CYCLIN_CCNA1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032447">
        <property type="entry name" value="Cyclin-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16500">
        <property type="entry name" value="Cyclin_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="206"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="299"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="303"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="427" mass="48102" checksum="ECF418D8A2469663" modified="2019-05-08" version="1">MYRSNPAALKRNADQENIYLVPQVGPVSQKQRTVLGVLNENDQQRRSLCQVSLKPCGTAALGPDNGFTSAKSCSGTECPAAFISSSSFNIYMEDEVQDEVEVSECNLTSELETKLGEVGNSSKPAEDYCLFLDLSEVSPMLVDSSMRSLRSHHEDSHVHVDYLAVEGYAEDIYQYLREAEEKSRPKFGYMKKQPDITPSMRSILVDWLVEVSEEYSLQTETLYLAINYLDRFLSCMSVLRGKLQLVGTAAMLVASKYEEIYPPEIDEFVYITDDTYTKKQLLRMEHLLLKVLSFDMTVPTVNQFLTQFLKEEGIGGQMGTLAMYIAELSLLEADVCLKYAPSLMAAAAYCLANYTINNAFWPEPLATFTGYSLVDIVPCLNDMHKTFLQAKFQPQQAIKEKYRSSKYLRISLIEPPATLPLHALKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU11</accession>
    <name>A0A401PU11_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0015519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008835">
        <property type="protein sequence ID" value="GCB76607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU11"/>
    <dbReference type="STRING" id="75743.A0A401PU11"/>
    <dbReference type="OMA" id="EMFSAMF"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000001">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF32">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB76607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="570" mass="64836" checksum="D2D466BE68F9A423" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUM1</accession>
    <name>A0A401PUM1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0016610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010146">
        <property type="protein sequence ID" value="GCB76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUM1"/>
    <dbReference type="STRING" id="75743.A0A401PUM1"/>
    <dbReference type="OMA" id="MSYCAIT"/>
    <dbReference type="OrthoDB" id="9941925at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001402">
        <property type="entry name" value="Prolrel_pep_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF15">
        <property type="entry name" value="PROLACTIN-RELEASING PEPTIDE RECEPTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01018">
        <property type="entry name" value="PRPRECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="365" mass="41278" checksum="9C33DABB2B2F6E15" modified="2019-05-08" version="1">MENETLDNSSLFNSSSLMNFPGTILLQKYKSFFILLYCALVAVACVGNIFLVGSIIVDKKLHNATNFFIGNLSVTDLLMCLTCVPLTLSYAFELRGWLFGKFMCHFVSLMQSAMVYVSVLSLTAIAVDRYIVVAYPIRQRVTLSCCALIVGGIWALSLALASPASIYATYVELKVTGNDINICEEFWRGMETERLAYSCVVILMSYMMPLSAVTISYCAITVHLKRRNMPGAVEQNQVRWNRKKRKTFFLLVISVVTFAICWMPLQILNLIRDLDVDFTIIDTRYINVVQVSCHWVAMSSSCYNPFIYASLHRKFRLQLRGYFRRWKRPSSFPSTRLSPFHTSISLVSEGPKAGTDNGSYVVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUU3</accession>
    <name>A0A401PUU3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA selenocysteine 1-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">tRNA selenocysteine-associated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0015572</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM TRSPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008894">
        <property type="protein sequence ID" value="GCB76914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUU3"/>
    <dbReference type="STRING" id="75743.A0A401PUU3"/>
    <dbReference type="OMA" id="FPGIFLQ"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12610">
        <property type="entry name" value="RRM1_SECp43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12612">
        <property type="entry name" value="RRM2_SECp43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000166">
        <property type="entry name" value="Trna selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034510">
        <property type="entry name" value="SECp43_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040434">
        <property type="entry name" value="TSAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041085">
        <property type="entry name" value="TSAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457:SF2">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17654">
        <property type="entry name" value="Trnau1ap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB76914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="288" mass="32500" checksum="95EBEE2580192CAF" modified="2019-05-08" version="1">MSRSLWMGDLENYMDENFISRAFATMGETVISVKIIRNRVTGTPAGYCFVEFTDQAAAERCLLKINGKKLPGASPPRRFKLNYATYGKQPDNSPEYSLFVGDLTPEVDDGMLYEFFVEKYPTCRGGKVVLDNLGNSKGYGFVKFSDEAEQKRALAECQGAIGVGGKALRLSVAIPKTNRVVKPPDYSQTYTYNYNQYYQPYQNYYTQWGYDQYTGSYSYSYQQYGYTQSTMQNYEEVGDDALEVHHGNMPLPAQGLSFPGIFLQPGGWGGQSQGLLHDYNHQCCSMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVK6</accession>
    <name>A0A401PVK6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018042">
        <property type="protein sequence ID" value="GCB77156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVK6"/>
    <dbReference type="STRING" id="75743.A0A401PVK6"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF475">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="77" mass="8938" checksum="FEC7A206BDD1D24D" modified="2019-05-08" version="1" fragment="single">AHSLDSDDNRIALYLCLQLAFNRQISEAIEQLQVALKLRNDDIHSLHLLTLLFSAQKHYQRALEVIDMAVNEYPENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXK2</accession>
    <name>A0A401PXK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009060">
        <property type="protein sequence ID" value="GCB77865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXK2"/>
    <dbReference type="STRING" id="75743.A0A401PXK2"/>
    <dbReference type="OrthoDB" id="9950567at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="8565" checksum="4E4BBA881CC8E277" modified="2019-05-08" version="1">MGMETGLGELPAFGVSPASRRDPQSFLESVCRTVVVQGVSALLAFPQSTGELLQLEFLSSTIRIPVVSIVGKQYPRQSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXP7</accession>
    <name>A0A401PXP7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium- and chloride-dependent creatine transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0019333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014289">
        <property type="protein sequence ID" value="GCB77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXP7"/>
    <dbReference type="STRING" id="75743.A0A401PXP7"/>
    <dbReference type="OMA" id="FHANIST"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF325">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB77892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30706" checksum="07D2F921AA673B87" modified="2019-05-08" version="1" fragment="single">MVIVFFCNTYYIMVLTWGAYYLCHSFAATLPWGTCNNTWNSPACSERIGSSNCSNGTAANCHLPAGMQSPIVEFWERKVLDLSSGLEEVGDISWQLTLCLLATWIVVYFCVWKGVKTTGKVVYFTATFPYIILIILFVRGVTLPGALEGIIYYLQPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNQFNNDCYKDAFILALVNSGTSFFAGFVVFSILGFMAQERGVDISEVAESGPGLAFIAYPKAVTLMPFPQVWAALFFIMLLLLGLGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY72</accession>
    <name>A0A401PY72_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016979">
        <property type="protein sequence ID" value="GCB78094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY72"/>
    <dbReference type="STRING" id="75743.A0A401PY72"/>
    <dbReference type="OMA" id="CEPLTEH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="152" mass="16235" checksum="54910D28FB6313F3" modified="2019-05-08" version="1" fragment="single">AHKTNTCEPLIKQTTTAVMNPTETSLIDLGSINTNMATESSSETMPVPEAKTTDVSRETNSFLSNSISAAAGSTSSSEFLNTSAIGEDPKLTSNGVVYWVLGVVVIVLLVGLVAAVYCVRRFKKNSSYGTRQPKESIEAEVWSNNQTQNSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYN8</accession>
    <name>A0A401PYN8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0016799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010405">
        <property type="protein sequence ID" value="GCB78216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYN8"/>
    <dbReference type="STRING" id="75743.A0A401PYN8"/>
    <dbReference type="OMA" id="RHARNPW"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF1">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="12309" checksum="606E0296A0C0AB2F" modified="2019-05-08" version="1">MANVKVAVRVRPLSKRENAEGSNIIVHVDEKVASIRNLKLDSRLDSPGNTRERNIEFTFDYCYWSVDSDSSNFAPQELQSNDKSELVDCYHLPTVRHARNPWRSTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZB9</accession>
    <name>A0A401PZB9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014426">
        <property type="protein sequence ID" value="GCB78494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZB9"/>
    <dbReference type="STRING" id="75743.A0A401PZB9"/>
    <dbReference type="OMA" id="NTEQRAM"/>
    <dbReference type="OrthoDB" id="5945029at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF142">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="204" mass="22300" checksum="89E6BF6DA879EC3A" modified="2019-05-08" version="1" fragment="single">PPLKDPTRYPEGGYYIYLEGNDGSEGDRAQLVSAPCKKTGAQCLRFWYHMYGVAQSMALKVYQVEGGIPVLMWLETGNKGNRWIAGEVGLQLSGKSQILIEAVRGNDYRSDVAVDDISFHTGCCGDMCDTTATTSTPTTAITVTPETVAKAVTKKIKQLVSCTNTEQRAMIVAVHVHKFRRLGARLIQVDLLSGHGDPEVFMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q167</accession>
    <name>A0A401Q167_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011940">
        <property type="protein sequence ID" value="GCB79169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q167"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="17881" checksum="62EB185F4CC52398" modified="2019-05-08" version="1" fragment="single">RIKELEERIEAQKRLIKELEEKLSFFGRSSSRQPARKATMKERKLDTVINYQITVLSQERPTLHQDNKYLKEHLTIHFEENRKSIKNVQRSKRVVPEVIQKSKKSLENHVLDLKDKFCKNVTKPFKEMDNVNGPKVSICNVWSTMKNYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1L6</accession>
    <name>A0A401Q1L6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
            <ecNumber evidence="10">6.1.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glutamate--tRNA(Gln) ligase EARS2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0021277</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Gln) + L-glutamate + ATP = L-glutamyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:64612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:23541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Glx) + L-glutamate + ATP = L-glutamyl-tRNA(Glx) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9713"/>
            <dbReference type="Rhea" id="RHEA-COMP:9716"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:18398"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EC" id="6.1.1.24" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01018570">
        <property type="protein sequence ID" value="GCB79272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1L6"/>
    <dbReference type="STRING" id="75743.A0A401Q1L6"/>
    <dbReference type="OMA" id="HGATNVM"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050561">
        <property type="term" value="F:glutamate-tRNA(Gln) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="18">
        <location>
            <begin position="2"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="19">
        <location>
            <begin position="347"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB79272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="477" mass="54037" checksum="4544ED8C43978FE7" modified="2019-05-08" version="1" fragment="single">FLHLGGLRTALYNYIFAKKHGGSFVLRIEDTDQSRLVPGAAESIENVLEWAGIPPDESPQRGGPYGPYKQSERLDLYLKATDTLVMKNAAYYCFCSPQRLEILKKEALRMRQTPKYDNRCRHLTLKQIEERLAQGCPHVIRFRMEEGAQSFEDLVYGLNRLDPASVEGDPVIIKADGFPTYHLANVVDDHHMKISHVLRGTEWLTSTSKHLLMYRAFGWDPPAFAHLPLLLNKDGSKLSKRQGNLLIQNLSQNGFLPEALLDIVTNSGSGFSGNRLGRILEELVREFDVTKITTHSALLDLDKLPEFNRIHLRQRVENVSSRQQLVTELQALVAKAFGDELIDGEALCTDYVERVLLHRKGHITRLQDLVSPAYSYLWIRPVVPRQQMLNLSTEGEKICSVVVRLLQTWPNDSVTPAELNSELRALQAQFTGTKYSVMMKFLRLVLSGQQQGPSVAEMMLSLGPKEACQRLQRVVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q284</accession>
    <name>A0A401Q284_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase complex subunit SAP18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">18 kDa Sin3-associated polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sin3-associated polypeptide p18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0016970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. For the ASAP complex, the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Forms a complex with SIN3A and HDAC1. Interacts with SUFU.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010675">
        <property type="protein sequence ID" value="GCB79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q284"/>
    <dbReference type="STRING" id="75743.A0A401Q284"/>
    <dbReference type="OMA" id="HHSNEDF"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.550:FF:000001">
        <property type="entry name" value="Histone deacetylase complex subunit SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017250">
        <property type="entry name" value="Hist_deAcase_cplx_SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037637">
        <property type="entry name" value="HDAC_SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="167" mass="19155" checksum="9CA9293EF3F7DBA5" modified="2019-05-08" version="1">MVRSPLLRERRGGNMAVESRVTQEEIKKEPEKPVDREKTCPLLLRVFTTNNGRHHRLDDFARGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFSFAIVYPDRKRPGYRVKEISTTVSGRKGPDDSMTLQSQKFQIGDYLDIAITPPSRAPPPPGRMRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q289</accession>
    <name>A0A401Q289_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016019">
        <property type="protein sequence ID" value="GCB79476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q289"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="198" mass="21867" checksum="838AEF15718D3E62" modified="2019-05-08" version="1">MLETGTGVELIKKKTQWIDNGNWNLTNLIESLDEARNYILEKENGPENLHRAGGKLGYTAVADKLGYTGAAGKLCYIGAAGELGCTGAAGELSCVELLLLVSWSVLDLLVNWAALNLLVNWAILELLVNWAVQELLVNFAALELLVNRVVLELLVKWFVLELLGSWALQELLLNWAVPDLLLSQAVMGLLVNWAYWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q392</accession>
    <name>A0A401Q392_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TSC22 domain family protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSC-22/Dip/Bun family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014759">
        <property type="protein sequence ID" value="GCB79791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q392"/>
    <dbReference type="STRING" id="75743.A0A401Q392"/>
    <dbReference type="OMA" id="SMNSSCY"/>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000002">
        <property type="entry name" value="TSC22 domain family, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047862">
        <property type="entry name" value="TSC22/BUN_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF23">
        <property type="entry name" value="TSC22 DOMAIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01289">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB79791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15193" checksum="01ECD7532942CD31" modified="2019-05-08" version="1">MNAECYKSLAMELGVYQLRNFSISFLSSLLGTENASVKLDSSSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKDLVARNSQLEQENNLLKTLASPEQLAQFQAQLQTTGCSPPVSQSGQSTQPTPPNGGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3G8</accession>
    <name>A0A401Q3G8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein lin-7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0017988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012146">
        <property type="protein sequence ID" value="GCB79977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3G8"/>
    <dbReference type="STRING" id="75743.A0A401Q3G8"/>
    <dbReference type="OMA" id="SAIREXA"/>
    <dbReference type="OrthoDB" id="10029564at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06796">
        <property type="entry name" value="PDZ_Lin-7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000076">
        <property type="entry name" value="Protein lin-7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017365">
        <property type="entry name" value="LIN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038039">
        <property type="entry name" value="Lin-7_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="13">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="91"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB79977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="205" mass="22637" checksum="65526BA6817D8941" modified="2019-05-08" version="1">MANPPNIAMTDVARAIELLEKLQRSGNVPPQKLQTLQRVLQSKFCSAIREVYEQLYETLDINGSPEIRAHATAKATVAAFAASEGHAHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGTVKLVVRYTPKVLEEMEARFEKMRTARRRQQHNSYSSLESRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3H4</accession>
    <name>A0A401Q3H4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0017027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010745">
        <property type="protein sequence ID" value="GCB79863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3H4"/>
    <dbReference type="STRING" id="75743.A0A401Q3H4"/>
    <dbReference type="OMA" id="FEMLQMR"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035773">
        <property type="term" value="P:insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000017">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase-like N isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF1">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="79"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="258"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB79863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39727" checksum="279B6856E93B737D" modified="2019-05-08" version="1" fragment="single">ELCRQHMAAKSSYARTETVDTSRVSSVSSQFSDAPQASPSSHNSTPSWCEEPVQSNMDISTGHMILAYMEDHLKIKDRLHKEWEALCAYQAEPNSCGVGQSEVNIKKSRNPDFVPYDHNRMILKAEVNPSRTDFINASPIIDHDPRMPAYIATQGPLSHTISDFWQMVWENGCTVIVMLTPLVEDSIKHCDRYWPDEGSSLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQSQETRTLTQFHFLSWPAEGIPSSTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYTLIDMVLNRMSKGVKEIDIAATLEHIRDQRPGMVRTKDQFEFALTAVAEEVNAILKALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3T4</accession>
    <name>A0A401Q3T4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012150">
        <property type="protein sequence ID" value="GCB79991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3T4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="14885" checksum="442504B796A2CA88" modified="2019-05-08" version="1" fragment="single">MSWEVRREKRCFAYSAFQQTPGRETPSTQIEVNRILNVLKPEWSLPRATGSFRPTDGASGVDMTPGFWNAEALSFRLYLPRMQDLPEHTLGIPQEWAQRDTLPPRTVNTLRVVNDNLLSLRLTPSGIKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4G5</accession>
    <name>A0A401Q4G5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0016142</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009568">
        <property type="protein sequence ID" value="GCB80263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4G5"/>
    <dbReference type="STRING" id="75743.A0A401Q4G5"/>
    <dbReference type="OMA" id="TVMDPLQ"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF5">
        <property type="entry name" value="HIGH AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB80263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="624" mass="68041" checksum="5F579AC3790C7043" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4S5</accession>
    <name>A0A401Q4S5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0016175</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 13">Cell membrane</location>
            <topology evidence="3 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the connexin family. Delta-type subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the connexin family. Gamma-type subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009620">
        <property type="protein sequence ID" value="GCB80368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4S5"/>
    <dbReference type="STRING" id="75743.A0A401Q4S5"/>
    <dbReference type="OMA" id="TKFVCNT"/>
    <dbReference type="OrthoDB" id="8875898at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000003">
        <property type="entry name" value="Gap junction protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002265">
        <property type="entry name" value="Connexin45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF6">
        <property type="entry name" value="GAP JUNCTION GAMMA-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01136">
        <property type="entry name" value="CONNEXINA6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="16">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="17">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB80368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="390" mass="45027" checksum="EA187B8D65B82413" modified="2019-05-08" version="1">MSWSFLTRLLEEIHNHSTFVGKLWLTVLIIFRIVLTVVGGESIYYDEQTKFVCNTGQPGCENVCYDAFAPLSHVRFWVFQIILIATPSIVYLGYAVHKIAGTEDHDYGRQKPRKHQYAVQWKQHRALEEAEDDHIEDPILYPEIELHRDKENPDQKSLTKHDGRRRIKRDGLMKIYVVQLLTRTAIELSFLVGQYILYGFEVAAKYQCQRDPCPHRVDCFVSRPTEKTIFLLIMYGVSCLCLVIDIWELMHLGFGMMRDILRNKQNSMTDASYSYPYTWNTPSAPPGYNIAVKPDQIPYTEISNAKMAYKQNKANIAQEQQYGSNDENIPANLESVQQQLKMAQERLDLAFQAYNEHHNPSNHPREKKRAGSNKSSISSKSGEGKTSVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4W4</accession>
    <name>A0A401Q4W4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-related protein Rab-22A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0018108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012314">
        <property type="protein sequence ID" value="GCB80410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4W4"/>
    <dbReference type="STRING" id="75743.A0A401Q4W4"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB80410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23467" checksum="02E0B00934F56A63" modified="2019-05-08" version="1">MEAATLVVVASSLTADMLTGVLAIEFQVHFKRQWKVMFETFHKLVEEFRALAPMYYRGSAAAIIVYDITKEETLQTLKNWVKELGQHGPPNIVVAIAGNKCDLTDAREVLEKDAKDYADSIHAVFVETSAKNAININELFAEISRRIPSTSVNPGANNKGFKLRRQPTDTRLLQATLWQALSQSVSLLNMSKSGETDEPGNGLTDKRQQSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q560</accession>
    <name>A0A401Q560_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0017206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010993">
        <property type="protein sequence ID" value="GCB80520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q560"/>
    <dbReference type="STRING" id="75743.A0A401Q560"/>
    <dbReference type="OMA" id="TINIGPY"/>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF3">
        <property type="entry name" value="HYCCIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB80520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="221" mass="24968" checksum="29A70EF8E46FA711" modified="2019-05-08" version="1">MGLYASAPAYMGLHASVPVYMGLYANVPVRMGLIEYLRLSSGKMLDSDIGVVEDWLSQFKTLPENQISCYAATLHQKTNIVPALYKVIQDPNSELLEPVCHQLFELYRSSEVRLKRLRASVRNLENQPGFQSLCSERHCSLNVHSVRKYLVKFILEIVDRDGNNKVLSFTIPSLSKPSVYHEPSSIGSMALTEGALSQHDLIRVVYSDLHPQRENFTAQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q584</accession>
    <name>A0A401Q584_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010989">
        <property type="protein sequence ID" value="GCB80512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q584"/>
    <dbReference type="STRING" id="75743.A0A401Q584"/>
    <dbReference type="OrthoDB" id="8941170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF37">
        <property type="entry name" value="SEMAPHORIN-3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019058862" description="Sema domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="5">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB80512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="173" mass="19442" checksum="3B87B4D2E78B548A" modified="2019-05-08" version="1">MAPLWNCLLLYLLTAQALAAQGRTLSNNPRLKMSYKDLVSRGAVTYQLDYSCCYNTLLLDEERGKLFVGSKNYLIALNLENISKQDKQIYWPAPVEWREECNWAGKDLHVSKATANCPDVLRVDSWRLARTGPGSFVSCSEMTPRPPPHPSPPHPRSDSSAPTTLLSQAIEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6K1</accession>
    <name>A0A401Q6K1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022533">
        <property type="protein sequence ID" value="GCB81006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6K1"/>
    <dbReference type="STRING" id="75743.A0A401Q6K1"/>
    <dbReference type="OMA" id="AHGYPRI"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47641:SF1">
        <property type="entry name" value="GOLGI-ASSOCIATED OLFACTORY SIGNALING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47641">
        <property type="entry name" value="PERIAXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="237" mass="23360" checksum="93248FC8E41B8C4B" modified="2019-05-08" version="1" fragment="single">KLPGAIDTEIPEESGPEIPVDSGPEIPEESGPAIPEESGPEIPEESGPEIPEESGPEIPVESGPESPVESGSEIPVESGREIPEESGPAIPEESGPEIPVESGPEIPEESGPAIPEESGPEIPEESGPAIPLGSGPEIPMGSGLEIPEESGPEIPVGSGPEIPVGSRPEIPVGSGPEIPVGSGPESPVGSGPESPVGSGPESPVGSGPESPVGSGPESPVGSGPESPVGQRTKSSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q734</accession>
    <name>A0A401Q734_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P53 apoptosis effector related to PMP-22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0021796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020039">
        <property type="protein sequence ID" value="GCB81188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q734"/>
    <dbReference type="STRING" id="75743.A0A401Q734"/>
    <dbReference type="OMA" id="FALCKEQ"/>
    <dbReference type="OrthoDB" id="8868135at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF4">
        <property type="entry name" value="P53 APOPTOSIS EFFECTOR RELATED TO PMP-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB81188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20699" checksum="0063F9BB7F2B5EE1" modified="2019-05-08" version="1">MNVNSNTVGEDCEGKDHWTVDNYGTDITERGRSGVQMGKPGRTLCPAVSDALSVVTVSKVPPFTEQLHRGLTPSWAKASAAMLIIGCILLIICFILSFLALCKGQVSLLKVIGLILFVAVLFQIIALIIYPVKFTETQIKNGDYEYSWSYGFGWGATILMIGCGVFFCCLPKYEEELYGQAKPIYFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q735</accession>
    <name>A0A401Q735_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOCKER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022651">
        <property type="protein sequence ID" value="GCB81195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q735"/>
    <dbReference type="STRING" id="75743.A0A401Q735"/>
    <dbReference type="OMA" id="QHEYQKE"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF76">
        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="119" mass="14196" checksum="43F4C5B8B216F8F0" modified="2019-05-08" version="1">MTLVDPDFFLQFPQGPLEVAQVFLADIPDDPKLFRHHNKLRLCFKDFMKRCEDALRKNKTLIGADQKEYHRELERNYHRLKESLQPMINRKIPQLYKSLIPSTSHRNSFSRSSLRKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8L7</accession>
    <name>A0A401Q8L7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022983">
        <property type="protein sequence ID" value="GCB81718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8L7"/>
    <dbReference type="OMA" id="VQFYGWE"/>
    <dbReference type="OrthoDB" id="9894570at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.175.10">
        <property type="entry name" value="Diphtheria Toxin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36542">
        <property type="entry name" value="GIG2-LIKE PROTEIN DRED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="48"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="230" mass="26196" checksum="04F3F711A836F626" modified="2019-05-08" version="1" fragment="single">PSLRFHLTAGEGDKYQKMSITFYGWEAINEDKGHLKPGQMLKDGRGYTMYHGTHKNDAANIIRSGFVPSKDGLLGPGVYVSRDRNKARAYPKTAADTDRVVFKLEVRVGKVKKIDRDNHPLQKTWHQQGYDCAWVPPKCGMLSIPSQKEEDCVWDPKRITVVDVAYANDLVKKDLRKLIREQTMAKEATVKDPCDVCGHRQYSSHEIQKCWGCETVVCPFMSRHVCNKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8W0</accession>
    <name>A0A401Q8W0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021748">
        <property type="protein sequence ID" value="GCB81819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8W0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="122" mass="13190" checksum="D187C688C754060F" modified="2019-05-08" version="1">MKLARICSSSYLGLFKNQTNGKFLLCTPVSMILFSRCMCCPRIGLIDSALVSSVRFASGPILSRFGARSYCGICTVNSAEGAVIARPMLGSCVKLQDQDVVKQSQSLKIGPFYSMCTVLCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q963</accession>
    <name>A0A401Q963_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023094">
        <property type="protein sequence ID" value="GCB81901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q963"/>
    <dbReference type="STRING" id="75743.A0A401Q963"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="12526" checksum="0EEE1E7A83658A14" modified="2019-05-08" version="1" fragment="single">MGRKGPLGPKGSKGSSGPSGQKGDTGLIGLPGAPGPPGEVIQPLPIRTPKKTRRSSDGMQADERDNILDYTNGMEDIFDSLDNLKMEVDRMKNPMGTHSNPARTCKDLQLSHPDFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q980</accession>
    <name>A0A401Q980_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0023316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01028343">
        <property type="protein sequence ID" value="GCB81930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q980"/>
    <dbReference type="STRING" id="75743.A0A401Q980"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF15">
        <property type="entry name" value="PHD FINGER PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB81930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="62" mass="6852" checksum="70D7720961CD87B5" modified="2019-05-08" version="1" fragment="single">SCSCCHRPGATIGCDVKTCPRTYHYYCAKLDKAQIKEDPSQGIYLILCQKHKEGAEDSSEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAQ2</accession>
    <name>A0A401QAQ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019476">
        <property type="protein sequence ID" value="GCB82459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAQ2"/>
    <dbReference type="STRING" id="75743.A0A401QAQ2"/>
    <dbReference type="OMA" id="QTHEREE"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF89">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="171" mass="19897" checksum="0CFB218E9EEB48FE" modified="2019-05-08" version="1" fragment="single">AQTHEREELFVQKLRQCCVLFDFVSDPLSDLKYKEVKRAGLNEMVEYITHNRDVITEAIYPEAVIMFSINLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLECADFQPNVAKKYVDQKFVLSQAIEELTTGSDFPYFIRNIHLNTEICFLSLKYGKVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBW0</accession>
    <name>A0A401QBW0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pectinacetylesterase family. Notum subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029985">
        <property type="protein sequence ID" value="GCB82878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBW0"/>
    <dbReference type="STRING" id="75743.A0A401QBW0"/>
    <dbReference type="OrthoDB" id="2015280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="53" mass="5789" checksum="639D708AE27B252A" modified="2019-05-08" version="1" fragment="single">FVPYCSSDVWSGTAPRTQQVDYAFMGSLILKEVIKDLVPKGIKLAKVVMLTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBX4</accession>
    <name>A0A401QBX4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01030000">
        <property type="protein sequence ID" value="GCB82889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBX4"/>
    <dbReference type="STRING" id="75743.A0A401QBX4"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016312">
        <property type="term" value="F:inositol bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF117">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="96" mass="11294" checksum="28C3D463D2758A43" modified="2019-05-08" version="1" fragment="single">GNKGGVVVRLSIYGHLICFLNCHLPAHIENTNQRLDSFERILDMQQFTGRKACAILDHDLVFWFGDLNFRIADHGLHFIRECITKKRYHLLWDKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDG9</accession>
    <name>A0A401QDG9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01031015">
        <property type="protein sequence ID" value="GCB83421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDG9"/>
    <dbReference type="STRING" id="75743.A0A401QDG9"/>
    <dbReference type="OMA" id="MLPEVMG"/>
    <dbReference type="OrthoDB" id="8251747at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="148" mass="15688" checksum="2317BF94E69464D2" modified="2019-05-08" version="1" fragment="single">MLPEVIGKALPEVIGKALPEVIGKALPEVIGKMLPEVIGKMLPEVMGKMLPEVIGKALPEVIGKMLPEVIGKMLPEVMGKALPEVIGKALPEVIGKMLPEVIGKALPEVIGKALPEVIGKMLPEVMGKMLPEVIGKMLPEVIGKMLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEA8</accession>
    <name>A0A401QEA8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EIF3F/CSN6-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01041822">
        <property type="protein sequence ID" value="GCB83710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEA8"/>
    <dbReference type="STRING" id="75743.A0A401QEA8"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF3F/CSN6-like C-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="42" mass="4948" checksum="426DB99B942D9520" modified="2019-05-08" version="1" fragment="single">MSRSCFLPGEVPFNHEILREAYALCHRLPVLSTDKFKTDFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHM0</accession>
    <name>A0A401QHM0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01117551">
        <property type="protein sequence ID" value="GCB84938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHM0"/>
    <dbReference type="STRING" id="75743.A0A401QHM0"/>
    <dbReference type="OMA" id="SERPTSQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="332" mass="36258" checksum="E7A48BC00F5F62A2" modified="2019-05-08" version="1" fragment="single">ASNATERAASQGEQLHRASRVAERAASQSEPRHRASSAAGRAAPQSEQSRRASSVAERAASQSEQRRRASCVAERAAPQAEQRRRASSVTERAASQSEQRHRASSAAERAAPQSEQRRRASRATERAASQGEQRRRASRATERAASQSEQYRRVSSTTERAAPQSEQRRRAGSTAERAASQSERRHRASGAAERAAPQSEQHRRASSATERAASQSEQHRRASSTAERAAPQSERRHRASSTAERAAPQSEQRHRASSVTERAAPQSEQRRRAGSVAERAAPQSEQRRRAGSTAERAGSQSKQHRRASSVTERAASQSEQHCRASSTTERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIG4</accession>
    <name>A0A401QIG4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
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        <name type="common">Cloudy catshark</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01131108">
        <property type="protein sequence ID" value="GCB85137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIG4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="50" mass="5584" checksum="1D47FCAEF7A4586E" modified="2019-05-08" version="1" fragment="single">ATLVSDLVKRGTTMLQNAMKDEKINLPELLEIVTIDLCEEGRQAVIKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJQ1</accession>
    <name>A0A401QJQ1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01176851">
        <property type="protein sequence ID" value="GCB85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJQ1"/>
    <dbReference type="STRING" id="75743.A0A401QJQ1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051493">
        <property type="entry name" value="CHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="220" mass="24614" checksum="D26DF0F24B752C5A" modified="2019-05-08" version="1" fragment="single">MLVKQVTEERATRTLYRIELLRKVREQILSHPQLEEHLQLCQPSPELPEWWESGRHDLELLTAAARHGVSRPDCHLMNDPDLSFRTCRLNYLQSQHPGSRSSTPLLPQYPTARTASPLPLALPLPSKPSERGRACVDHRGLEEDFGSPAGLGSRVELCPVDYRHGPFEPRSLVDKRLPQAAAEDWGKESDSESDKSSSPDASPSLSEVSDDEKDPDDKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLF4</accession>
    <name>A0A401QLF4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01267770">
        <property type="protein sequence ID" value="GCB86251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLF4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="79" mass="8274" checksum="959ED40B5E79729E" modified="2019-05-08" version="1" fragment="single">REDVGVEGEDGVREDVGVEGEDGVREDVGVEGEDGVRVDVGVEGEDGVREDVGVEGEDRVREDAGMEGEDGVKGDGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNP0</accession>
    <name>A0A401QNP0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionyl/Leucyl tRNA synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0027622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01371619">
        <property type="protein sequence ID" value="GCB86932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNP0"/>
    <dbReference type="STRING" id="75743.A0A401QNP0"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB86932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="59" mass="6893" checksum="F97ED12BC295BBEE" modified="2019-05-08" version="1" fragment="single">MLYICGTDEYGTATETKALEEGLTPQQICDKYHAIHSHIYRWFSISFDYFGRTTTDHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGF0</accession>
    <name>A0A401NGF0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003613">
        <property type="protein sequence ID" value="GCB59945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGF0"/>
    <dbReference type="STRING" id="75743.A0A401NGF0"/>
    <dbReference type="OMA" id="LLQDWAP"/>
    <dbReference type="OrthoDB" id="7881762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000003">
        <property type="entry name" value="NFkB p65 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000046">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030492">
        <property type="entry name" value="RHD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF4">
        <property type="entry name" value="PROTO-ONCOGENE C-REL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01204">
        <property type="entry name" value="REL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB59945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="638" mass="71645" checksum="18555F20F9C07859" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGG7</accession>
    <name>A0A401NGG7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006127">
        <property type="protein sequence ID" value="GCB59811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGG7"/>
    <dbReference type="OMA" id="TEGAQAW"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB59811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="255" mass="26449" checksum="060B4B0EFBB084FC" modified="2019-05-08" version="1" fragment="single">MLPPSNGAQAWLTSPMLPPTEGAQAWLTSPTLPPSEGAQVWLTSPTLPPSEGAQAWLTSPTLSPNEGAQAWLTSPTLSPNEGARAWLTSPTPPPSEGAQVCLTSPTLPPSVGAQAWLTLPTLPPSEGAQAWLTSPTLSPSEGAQAWLQSPTLPPSEGTQAWLKSPTLPPSEGAQAWLTSPTPTPSEGPQAWLKAPTLPSTEGAQAWLTSPTLPPSEETQAWLMSSTLPPSEGAEAWLTSLTLSPSEGAQAWLTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHG4</accession>
    <name>A0A401NHG4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0009155</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a guanylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-GMP-RNA + a 5'-end dephospho-uridine-RNA</text>
            <dbReference type="Rhea" id="RHEA:81323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="Rhea" id="RHEA-COMP:19658"/>
            <dbReference type="Rhea" id="RHEA-COMP:19659"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
            <dbReference type="ChEBI" id="CHEBI:231849"/>
            <dbReference type="ChEBI" id="CHEBI:231850"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an adenylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-AMP-RNA + a 5'-end dephospho-uridine-RNA</text>
            <dbReference type="Rhea" id="RHEA:81383"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="Rhea" id="RHEA-COMP:19675"/>
            <dbReference type="Rhea" id="RHEA-COMP:19676"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
            <dbReference type="ChEBI" id="CHEBI:231879"/>
            <dbReference type="ChEBI" id="CHEBI:231881"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81384"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003658">
        <property type="protein sequence ID" value="GCB60310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHG4"/>
    <dbReference type="STRING" id="75743.A0A401NHG4"/>
    <dbReference type="OMA" id="PRSKCGE"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000001">
        <property type="entry name" value="Ribonuclease T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB60310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="258" mass="30159" checksum="6FA6F08710C979A7" modified="2019-05-08" version="1">MACQKGKGIQRKWMFAWIYPPLLVIFILPEVWDCNAFHPWHSIILSHHWPETVCLMVKETCKIPPNVDYWTVHGLWPKKNQMCNNSWPFKEENVEDILSELEQWWPDVLHPNSTQLWKHEWQKHGTCAATLESLDTQEKYFSKALELYQRIDLTSVLKKFHILPSSNYYTLDNIENAILKTYGVTPKIQCLPPTGGSSVQILGQIELCFTKEFQLLNCTETAPSMLAFKNGRHHTAYLGFFECEPGQQIYYPPIQHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHH6</accession>
    <name>A0A401NHH6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0014146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007486">
        <property type="protein sequence ID" value="GCB60323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHH6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10119" checksum="02B40220BFFF7895" modified="2019-05-08" version="1">MEIVCKTSIDHRDAVKNISIPCILKYLLKLDWIGFVYCHVYRGTVKSIFLRAAQQIIKVVGAYKTTSIYSIYNQETLGLSLLHVLDAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHR0</accession>
    <name>A0A401NHR0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 15">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0003931</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:39159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:74278"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:39160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:45813"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 15"/>
    <dbReference type="EMBL" id="BFAA01001118">
        <property type="protein sequence ID" value="GCB60415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHR0"/>
    <dbReference type="STRING" id="75743.A0A401NHR0"/>
    <dbReference type="OMA" id="CGHTWIF"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF16">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB60415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="247" mass="28380" checksum="9EBD7BD4E9B52725" modified="2019-05-08" version="1">MEPELRAEEVPGDHPPAKEAAPRARYKLKTLYLFTYNLIQFCGYSWISTNITARFLTFGEDSLVDTYHSIGAVMGCCQLLSVLELIHILSGVEQSPFLPRFLQVTERNIILFVVITSQEEMQSKNVVWALFSLWSTLDVIKYPYRMLSVIGTDLQILSWIHHCLWIPLSPSIMVTEVIATYQSLPYFEILGTYSFQLPGPIAVPIHFPYVLQLYCLILALGLYSSCCQFYEELEQNTRRCTMKSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI01</accession>
    <name>A0A401NI01_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006258">
        <property type="protein sequence ID" value="GCB60496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI01"/>
    <dbReference type="OrthoDB" id="5987630at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9869" checksum="1E7AAEDE53BBAAC6" modified="2019-05-08" version="1">MINVTATKLRNPWSRGTPCHYQALLGKVFVHVTLTRLQMLAFLAYPESQCSFREGRTIADMIFSQEKCSEELGPVYIDRTKAFGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI06</accession>
    <name>A0A401NI06_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007518">
        <property type="protein sequence ID" value="GCB60511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NI06"/>
    <dbReference type="OMA" id="EICELMH"/>
    <dbReference type="OrthoDB" id="42382at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06762">
        <property type="entry name" value="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06763">
        <property type="entry name" value="PDZ7_PDZD2-PDZ4_hPro-IL-16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="354"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1752"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1881"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
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        </location>
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            <begin position="1058"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="1845"/>
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        </location>
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        <location>
            <position position="1"/>
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            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="GCB60511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1970" mass="216480" checksum="FA107A7F127C847B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI13</accession>
    <name>A0A401NI13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012753</name>
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    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006262">
        <property type="protein sequence ID" value="GCB60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI13"/>
    <dbReference type="STRING" id="75743.A0A401NI13"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
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    <dbReference type="PROSITE" id="PS50005">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="109"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB60515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28280" checksum="19EB0938EAD9EBF9" modified="2019-05-08" version="1">MDRESEDAELSEKLGTVLNVSADEREKQTVPTEHLNFESDSGELSPVKVDPSGASGNAEKPCIADGETAEDHFFECRESLGTDGFVGMEDDVVNLELEDDSETTEAKKLEFDEEYLRELEKDLPEEEKKRRQGESLTLKEVGNGQFKKGEYTEAENSYTEALGVCPAYYQKDRSILYSNRAAARMKLRLPQQIEERNEKMKEEMLGKLKDLGNMVLRPFGLSTENFLLNKDPNSGSYSINFVQNPNNNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIW8</accession>
    <name>A0A401NIW8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger and BTB domain-containing protein 7A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0004006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001145">
        <property type="protein sequence ID" value="GCB60831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="75743.A0A401NIW8"/>
    <dbReference type="OMA" id="TQTQGLH"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001448">
        <property type="entry name" value="Zinc finger and BTB domain containing 7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000115">
        <property type="entry name" value="Zinc finger and BTB domain containing 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000099">
        <property type="entry name" value="Zinc finger protein 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF6">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="460"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB60831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="65340" checksum="435CD391C3CBD95D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ60</accession>
    <name>A0A401NJ60_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0012822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006325">
        <property type="protein sequence ID" value="GCB60931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ60"/>
    <dbReference type="STRING" id="75743.A0A401NJ60"/>
    <dbReference type="OrthoDB" id="7788762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000019">
        <property type="entry name" value="Aryl hydrocarbon receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF17">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB60931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="480" mass="53929" checksum="6F0F29D38C1CAA01" modified="2019-05-08" version="1" fragment="single">IPENSSLCSSVINYNPHDLPPENSSFMKRSFICRFRCLLDNSSGFLTLNFQGRLKFLHGQNKKAEDGVPIPPQLALFAVATPLQPTSILEVRTKTLIFQTKHKLDFTPLAVDTKGKFVLGYTETELCMRGTGYQFIHAADMMYCADNHVRMIKTGESGMTVFRLLTKQSSWVWVQANARLVYKGGRPDTIICKQRPLTNEEGEEHLRKRSMQLPFSFATGEAVLYEINPLLLGHLESFEAKGKSGKKVSTGANGIDQKNGINPSSLLGAMMIQNPSAYSPYRETNFNIDDVFANDFAVINVPGDFWPQANDRNSSNKQQPMNLDDPLSTIMDILSQKNADENDLCDTLENLDVDLENTELEQWEETLMKIDNNTSLPDDFNDMLTSDFILSCVEDMLTKTSPKAKTFSQESFNTMQVNLMGPDQQNPFGSLQQKSFGSDAQNSAMPGWTGTLELEQRIKGRSAELRTWNTGHPDFVCREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK76</accession>
    <name>A0A401NK76_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001172">
        <property type="protein sequence ID" value="GCB61274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK76"/>
    <dbReference type="STRING" id="75743.A0A401NK76"/>
    <dbReference type="OMA" id="STFERSY"/>
    <dbReference type="OrthoDB" id="10249393at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="275" mass="31031" checksum="189C3463DDEF1344" modified="2019-05-08" version="1">MKTVLTVSTQELAHIVTALYDICLPNVGPKDLRSTICAIGTKTIILVRNEQEVYEEYSQKTVIRPIVNITGTKSSCCTENLKEEKLRVFAAVFSDTESSEEDSKSNSDQEENENEERLKAGLKHFLSSVQERRQQRKSGQENGDLSCTALGIEARIVAALSYVRSLTKSGDRVVQLMLLSTRKRYRGCGVGHYLMQCILQDPAVVGKYDAIVTHADSNAVKFFTHCGFSNDVILNRKFKELEGDWTYTTLMSYFPPFSMGKNKLSYFWLVARKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLM2</accession>
    <name>A0A401NLM2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nectin cell adhesion molecule 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0014385</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007700">
        <property type="protein sequence ID" value="GCB61785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLM2"/>
    <dbReference type="STRING" id="75743.A0A401NLM2"/>
    <dbReference type="OMA" id="FHENPIT"/>
    <dbReference type="OrthoDB" id="9442762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000304">
        <property type="entry name" value="Nectin cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000298">
        <property type="entry name" value="Nectin cell adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF12">
        <property type="entry name" value="NECTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="130"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB61785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="266" mass="28932" checksum="15F79358DE8B9B00" modified="2019-05-08" version="1" fragment="single">PQVEWSSSDANKQGTLAGPVVVDKKISAILDKNVTLKCLVTVKETVTQISWEKQEHGTSDTIAVFHPLYGTSIQGNYEGRAVFTNPSLKDATILITRVGFSDSGIYICKVVTFPLGNYQEASIVTVIVEPTITVGGGPQPLVDGANETVAAICTAANGKPAAVIFWETDLIGEQEQTKISAPNQTVTVVNRFKIVPSRFVRKRPITCIVRHPPLNTTTRVPYILDVQYAPEVTVLGYDGNWFVGRQNVQLKCKADANPSPSAYIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMU3</accession>
    <name>A0A401NMU3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome non-ATPase regulatory subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">26S Proteasome regulatory subunit RPN11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0009476</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD4, a base containing 6 ATPases and few additional components. Within the complex, PSMD4 interacts with subunit PSMD7 through their respective MPN domain. Interacts with TXNL1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M67A family. PSMD14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003876">
        <property type="protein sequence ID" value="GCB62193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMU3"/>
    <dbReference type="STRING" id="75743.A0A401NMU3"/>
    <dbReference type="OMA" id="LIPQQNM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022624">
        <property type="term" value="C:proteasome accessory complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="13">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="314" mass="35062" checksum="5A81798229404222" modified="2019-05-08" version="1" fragment="single">HERIMDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLSKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKLNETVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVVMTSNIVQCLAAMLDTVVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMU6</accession>
    <name>A0A401NMU6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP-5 complex subunit zeta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002555">
        <property type="protein sequence ID" value="GCB62190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMU6"/>
    <dbReference type="STRING" id="75743.A0A401NMU6"/>
    <dbReference type="OMA" id="PVMMSED"/>
    <dbReference type="OrthoDB" id="744564at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044599">
        <property type="term" value="C:AP-5 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028222">
        <property type="entry name" value="AP5Z1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055450">
        <property type="entry name" value="AP5Z1_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056856">
        <property type="entry name" value="TPR_AP5Z1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056857">
        <property type="entry name" value="TPR_AP5Z1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14764">
        <property type="entry name" value="SPG48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25153">
        <property type="entry name" value="TPR_AP5Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25154">
        <property type="entry name" value="TPR_AP5Z1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP-5 complex subunit zeta-1 N-terminal TPR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 ARM repeats" evidence="1">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 C-terminal TPR" evidence="3">
        <location>
            <begin position="382"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="83879" checksum="ADADB20CA2D4839F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMW7</accession>
    <name>A0A401NMW7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">T-box transcription factor TBX21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">T-cell-specific T-box transcription factor T-bet</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription factor TBLYM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0009477</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003876">
        <property type="protein sequence ID" value="GCB62194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMW7"/>
    <dbReference type="STRING" id="75743.A0A401NMW7"/>
    <dbReference type="OMA" id="LCNRVYM"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072676">
        <property type="term" value="P:lymphocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000011">
        <property type="entry name" value="T-box transcription factor TBX21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032385">
        <property type="entry name" value="T-box_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF201">
        <property type="entry name" value="T-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16176">
        <property type="entry name" value="T-box_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="T-box" evidence="16">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="355"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB62194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="458" mass="49750" checksum="FDC61BF04DE1745F" modified="2019-05-08" version="1">MIITKQGRRMFPFLSFNISGLDPTAHYNIFVDIILADPNHWRFQGGKWVPCGKADTNVQGNRIYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGAEDSNQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCEVDRLTPSPSDSPRSQIVPSSRYAVTQSFLQEQFVNNYAKARFHHAGPGAGGGGERSVPHSNGLLSPQQAEEPAAPSPQRWFVTPLQQPANNRLDFSAYDTDFAGNAILSYGVGVKALPLQAGTRPLGYYPDPSGWGARSPQYSCKSSSVLPWARGASTNSYLEEAAAAAAAAAAEGLGPGSGPGSERSPLAAAAEDTKPKELPDSAWIEAPSSIKSIDSSDSGIYEQAKRRRISADGPPPPAPATESPSPLKSEALTPRDCEKNCAKEMAFYGFYSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNQ6</accession>
    <name>A0A401NNQ6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003910">
        <property type="protein sequence ID" value="GCB62510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNQ6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="11977" checksum="7D80BF0A8023AF29" modified="2019-05-08" version="1">MEMRSWRLEMRSCRLEMRSCRLEMRSWRFGDEELEVGDEESVFGEEESGSGDEESGFGDEEPGFGDEEPGFGDEEPGFGDEESGFGDEESGFGDEESGFEMSRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP06</accession>
    <name>A0A401NP06_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Optic atrophy 3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play some role in mitochondrial processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007822">
        <property type="protein sequence ID" value="GCB62648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP06"/>
    <dbReference type="STRING" id="75743.A0A401NP06"/>
    <dbReference type="OMA" id="WAEFEGT"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18353" checksum="AE4E0059FC35820B" modified="2019-05-08" version="1">MVVGAFPIAKLLMLGVRQISRPLANSIKANARRSQFFKRYICLPPAQIYHWVEMKTKMRMMGFKSGQVQPLSEEVAADLGAELLGEAFVFIIGGACILAEYVRQSSNSARKEEELSSMLQSLQEQVSHLSLTVEELDARVRENNRLVHSLPQALKRAEGLGHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP96</accession>
    <name>A0A401NP96_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thrombospondin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007824">
        <property type="protein sequence ID" value="GCB62674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP96"/>
    <dbReference type="STRING" id="75743.A0A401NP96"/>
    <dbReference type="OrthoDB" id="10060752at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000039">
        <property type="entry name" value="Collagen XV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019364800" description="Thrombospondin-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="4">
        <location>
            <begin position="120"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB62674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="309" mass="33574" checksum="CD5066C919BAD8CC" modified="2019-05-08" version="1">MPVGIVAVSVCLLLCSSRVHGQWNWWSRLWGTDQSTAAPSTTIRASLQPPTSGHLPGTVVGLEAQSIPVAKQAGHTQSLGSRLEKQSSALRKNSAGGRTEFKSVGQLQQRNLTERGSNDHIDLTGLIGVPLPPSVAFITGYEGFPAYSFGPGANIGRLTKTMIPQSFYRDFAILVTIKPANGDGGVLFAITNSYQNIIYLGVKLTAVWNDSQRIVLFYTESGSQTSHEVASFEVPPMTNKWTRFALSIEDELVTLYLDCDEYHQSTFTRSRQALFFEPSSGIFIGNAGGAGLNKFIVSGIEIFFNCVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQA4</accession>
    <name>A0A401NQA4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000015">
        <property type="protein sequence ID" value="GCB63045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQA4"/>
    <dbReference type="STRING" id="75743.A0A401NQA4"/>
    <dbReference type="OMA" id="ICNTICC"/>
    <dbReference type="OrthoDB" id="6083617at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF44">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="8866" checksum="48283043E8B62016" modified="2019-05-08" version="1">MPSAETRSYLPWSIFNLTCCFFPLGIAAIIYSCRVQSAIDLGNSERAKRASSIAKNLNIAATVIGIIAIIIIVVIYFTIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQD6</accession>
    <name>A0A401NQD6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002636">
        <property type="protein sequence ID" value="GCB63121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQD6"/>
    <dbReference type="STRING" id="75743.A0A401NQD6"/>
    <dbReference type="OMA" id="FNVCLAM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="935" mass="95139" checksum="425525B9CCA9F3CE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQG4</accession>
    <name>A0A401NQG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0000115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000016">
        <property type="protein sequence ID" value="GCB63105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQG4"/>
    <dbReference type="STRING" id="75743.A0A401NQG4"/>
    <dbReference type="OMA" id="NIYRTGR"/>
    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF51">
        <property type="entry name" value="NEUREXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="35"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB63105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="21104" checksum="5AEB15FCD14929DB" modified="2019-05-08" version="1">MSEELLINRVSELEGKLRDGVISSNIYRTGREEYVATFKGSEYFCYDLSQNPIQSSSDEITLSFRTLQRNGLMLHTGKSADYVNLALKDGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVGSILSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQJ2</accession>
    <name>A0A401NQJ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0009628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BACURD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003981">
        <property type="protein sequence ID" value="GCB63171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQJ2"/>
    <dbReference type="STRING" id="75743.A0A401NQJ2"/>
    <dbReference type="OMA" id="AEICCTS"/>
    <dbReference type="OrthoDB" id="2333377at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18399">
        <property type="entry name" value="BTB_POZ_KCTD10_BACURD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000013">
        <property type="entry name" value="BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF14">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB63171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="354" mass="40338" checksum="C433165BFB5F1283" modified="2019-05-08" version="1">MTASVAAGIRLPPVIGQRAQRWPLRWSPRRQTRDGFNFPLRNEERMSGESVVSPVPAASTRTTSFKGASPSSKYVKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGAVLNYLRDGAVPLPETNREIEELLAEAKYYLVQGLVEECQAALQQKETYEPFCKVPVITSNKEEQRLIATSKKPAVKLLYNRSNNKYSYTSNSDDNMLKNIELFDKLSLRFNGRVLFIKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYETQDGRGPDNALLEATGGAAGRSHHLEEEEERERIERVRRIHIKRPDDRSHLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQS8</accession>
    <name>A0A401NQS8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0013166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006623">
        <property type="protein sequence ID" value="GCB63194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQS8"/>
    <dbReference type="STRING" id="75743.A0A401NQS8"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3590.10">
        <property type="entry name" value="acid-sensing ion channel 1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF128">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB63194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="174" mass="20563" checksum="C8762724FD55BCA2" modified="2019-05-08" version="1">MECAERVAFYFSYPHVAKLEEVATNNLVFPAVTICNLNEFRFSKLTVNDLYHAGELLGLLNVHLEIQSPQLADPIVLKALKKKADFTHYKPRIFNMREFYDRVGHSLKDMMLYCKFRGVRCTHKDFKTLCTAKICSLRFDFLWYDVVTKHHNLHLVMKLELALEWLKSMKKFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRM0</accession>
    <name>A0A401NRM0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000026">
        <property type="protein sequence ID" value="GCB63499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRM0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB63499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="414" mass="46548" checksum="62D49A85C0196A9A" modified="2019-05-08" version="1">MVKDGINPALTKIEEMVLPVGNTYQEIMNWSMKPEAKYEKNPKVAITQTGKFQLQSGDDFYMAGKDTLRALQRDTLDGSGFKTRKRQQRDIIEQAVGGFGAGISSGNVLSIAEIREEIEGVNGQLRAAVKDIHQDAETATDLRQQVNQLVGKELKQLQPYQSTINELIDRQSAISKELDRVQTCNMYATHLLQSLHANLLQLDAHRLPNWASNAEFKACIKTTHQAADQLRELTLVSSVPFDNDNHTVLLRTMLKIPRAEKSSTHERFQGNTLRDVGNGMLIKLKDAPEHAIQRAARTYSIDIRICKGGGNNWLCPEKAISTEDYCGYITYENCTLAIEVNNQTMFNSVQYLVNYYTVMSYNNYIKGSIVFELPGHDGVLTSLSEYITIGCHELIPHRNVSTVEGDDLERMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT22</accession>
    <name>A0A401NT22_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005414">
        <property type="protein sequence ID" value="GCB64038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT22"/>
    <dbReference type="STRING" id="75743.A0A401NT22"/>
    <dbReference type="OMA" id="FPAVSWP"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20034">
        <property type="entry name" value="FH_FOXQ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000071">
        <property type="entry name" value="Forkhead box F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047518">
        <property type="entry name" value="FH_FOXQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF206">
        <property type="entry name" value="FORKHEAD BOX PROTEIN Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="275" mass="30691" checksum="E3560D2DD9A890E9" modified="2019-05-08" version="1">MNLEVFASSGFGGKPAEVCSDSEGSVPSPLSVEEELGSDGDCVANSPVPTTPGSEGKAKTYTRRPKPPYSYIALIAMAIRDSASGRLTLAEINDYLMKKFPFFRGTYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRRKRIGRKLLKEAGAGDKRMEVMPGIISVPGKDEGAGAKFSSSFAIDSILSTPFQRREDRVPEDRVACNFVNVEQSWFGEDSLPDEMTRLLKHSRSIEDYRTKAGKVGGHKLFWSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU67</accession>
    <name>A0A401NU67_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001368">
        <property type="protein sequence ID" value="GCB64409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NU67"/>
    <dbReference type="OMA" id="HVMSVFT"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="1707"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB64409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1994" mass="224208" checksum="8017457EB8ED7FED" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV67</accession>
    <name>A0A401NV67_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0014811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008096">
        <property type="protein sequence ID" value="GCB64778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NV67"/>
    <dbReference type="STRING" id="75743.A0A401NV67"/>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004999">
        <property type="term" value="F:vasoactive intestinal polypeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF24">
        <property type="entry name" value="VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="12396" checksum="502DCAB412E6C6F8" modified="2019-05-08" version="1">MEIRMRNPGLTVHILYTAPISLTILVNFILFISIIQILIQKVYSSDSRGSEYRQYLRLAKSTLLLIPLFGVNYIVFVFVPDHLNVYFRLVFDLALGSFQVGNHDTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVQ5</accession>
    <name>A0A401NVQ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBSPON-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008119">
        <property type="protein sequence ID" value="GCB64966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVQ5"/>
    <dbReference type="STRING" id="75743.A0A401NVQ5"/>
    <dbReference type="OMA" id="FREKYVC"/>
    <dbReference type="OrthoDB" id="98591at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF6">
        <property type="entry name" value="SOMATOMEDIN B AND THROMBOSPONDIN TYPE 1 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBSPON-like C-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="14123" checksum="B96EC26A7A7C93CB" modified="2019-05-08" version="1">MSAGPEVAKILPDSYKRNFKDPWKRPHMMAKEQKPSYCTYFRIKEVSPSCRLGLRISYRFREKYVCVECQGEAMGIRDRCEGDGLEGSRTFWTAASIPGCQGSWVRESLSEDCRCPPQSLIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWD6</accession>
    <name>A0A401NWD6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005539">
        <property type="protein sequence ID" value="GCB65193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWD6"/>
    <dbReference type="STRING" id="75743.A0A401NWD6"/>
    <dbReference type="OMA" id="GSYAVHE"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001234">
        <property type="entry name" value="GPCR_3_mGluR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01053">
        <property type="entry name" value="MTABOTROPC3R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019219195" description="Receptor ligand binding region domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="8">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB65193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="164" mass="17841" checksum="CE97BDEC3BA31AFC" modified="2019-05-08" version="1">MSHSLQLIFLHLLLQATVLSFSNLPSGKKEIAIEGDLVIGGLFPIHEKGNGLEDCGRTNEQRGIQRLEAMLFALDAINKDPNILPGIQLGAHILDTCSKDTYALEQSLEFVRSSLTKVDETEYICPDGSYAIHDDTAFAIAGVIGGSYSDVSIQVRNTQDFTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXF8</accession>
    <name>A0A401NXF8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0007745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002859">
        <property type="protein sequence ID" value="GCB65561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXF8"/>
    <dbReference type="OrthoDB" id="8931130at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="7840" checksum="6C1A44E3F3823460" modified="2019-05-08" version="1">MHGQLGNLTQALRELRQLLWKYSRGGSSASHHIQEHILCSCDPHRGAAPTVWPLQDLIFGCLVLITFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXQ4</accession>
    <name>A0A401NXQ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Histone-lysine N-methyltransferase NSD2</fullName>
            <ecNumber evidence="25">2.1.1.357</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">H3-K36-HMTase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Multiple myeloma SET domain-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Nuclear SET domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Nuclear receptor-binding SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="ORF">scyTo_0009984</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="40 41" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60308"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.357"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9786"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Interacts with HDAC1. Interacts (via PHD-type zinc fingers 1, 2 and 3) with SALL1. Interacts (via PHD-type 1, 2 and 3) with SALL4. Interacts with NANOG. Interacts with OGT. Interacts (via HMG box) with NKX2-5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="40">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.357" evidence="25"/>
    <dbReference type="EMBL" id="BFAA01004216">
        <property type="protein sequence ID" value="GCB65652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NXQ4"/>
    <dbReference type="OMA" id="CQEHEEL"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140954">
        <property type="term" value="F:histone H3K36 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21991">
        <property type="entry name" value="HMG-box_NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15654">
        <property type="entry name" value="PHD3_NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15658">
        <property type="entry name" value="PHD4_NSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000004">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000025">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000093">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000106">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000201">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000024">
        <property type="entry name" value="Histone-lysine N-methyltransferase NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000057">
        <property type="entry name" value="Histone-lysine N-methyltransferase NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041306">
        <property type="entry name" value="C5HCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047443">
        <property type="entry name" value="HMG-box_NSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047441">
        <property type="entry name" value="PHD3_NSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047458">
        <property type="entry name" value="PHD4_NSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055197">
        <property type="entry name" value="PHDvar_NSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17982">
        <property type="entry name" value="C5HCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23004">
        <property type="entry name" value="PHDvar_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0010">Activator</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="18 32" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="21 32" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="20" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 31" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="37">
        <location>
            <begin position="254"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="35">
        <location>
            <begin position="502"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="34">
        <location>
            <begin position="755"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="34">
        <location>
            <begin position="919"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="37">
        <location>
            <begin position="968"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="AWS" evidence="39">
        <location>
            <begin position="1102"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="36">
        <location>
            <begin position="1154"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="38">
        <location>
            <begin position="1278"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="32">
        <location>
            <begin position="502"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="405"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="567"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="661"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1058"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1299"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1430"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="33">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="33">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="1058"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="33">
        <location>
            <begin position="1309"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00050654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00064671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00066810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00068932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00079521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00080495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00081710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00081785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="GCB65652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1460" mass="163497" checksum="DD75905EFFDD9FBD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY20</accession>
    <name>A0A401NY20_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphofurin acidic cluster sorting protein 1/2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006918">
        <property type="protein sequence ID" value="GCB65740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY20"/>
    <dbReference type="STRING" id="75743.A0A401NY20"/>
    <dbReference type="OMA" id="SHLKCAY"/>
    <dbReference type="OrthoDB" id="28829at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF15">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="268" mass="29350" checksum="9B09DE0538DBB479" modified="2019-05-08" version="1" fragment="single">YLITVQEIPDVVARVTKYISSANISHQLPIAEAMLTYKQKSPDEDSCQKFIPFIGVVKVGIVEQSSATSGDSDDAATSGSNILSSTPPMLSPAMKEASPTPPSSPSVGSGLYSSSQSLGHSGELMGLQVDYWIAQQLADKKKDPEKKDGTAKNTLKCTFRSLQVSRLPNGGEIPTLPTMSMIVVTKEKNKKVMFLPKKTKDKELESKSQVIEGISRLICTAKQQQTMLRVTIDGVEWNDVKFFQLAAQWSSHVKYFPIGIFSHLKCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYX3</accession>
    <name>A0A401NYX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ras-related protein Rab-12</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">scyTo_0010047</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Recycling endosome membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01004253">
        <property type="protein sequence ID" value="GCB66069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYX3"/>
    <dbReference type="STRING" id="75743.A0A401NYX3"/>
    <dbReference type="OMA" id="KTSIMER"/>
    <dbReference type="OrthoDB" id="8821495at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04120">
        <property type="entry name" value="Rab12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000568">
        <property type="entry name" value="Putative Ras-related protein Rab-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041830">
        <property type="entry name" value="Rab12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="GCB66069.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
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    </evidence>
    <sequence length="253" mass="28308" checksum="597639A3432DE117" modified="2019-05-08" version="1">MDRTAGPKRRGPAGGLSSNSRSLSANSLTAGGASPKPSPASSRRRRQPPRPADYKLQVIIIGSRGVGKTSLMERFTDDTFSEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIVLVYDITKKETFEDVPKWMKMIDKYASEDAELLLVGNKLDCEVDRTISRQQGEKFALQVTGMRFCEASAKDNYNVSEIFLKLVDDILNKMHDVPRHELSNSILSLQPEPEIPPELRPHVRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZB4</accession>
    <name>A0A401NZB4_SCYTO</name>
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        <recommendedName>
            <fullName evidence="3">Piezo TM1-24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010066</name>
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        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT 2 ISOFORM X1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
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            <end position="25"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB66207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1103" mass="126920" checksum="8FDF484BB48E4388" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZF0</accession>
    <name>A0A401NZF0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Synphilin-1 alpha-Synuclein-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0004931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="GHNDINR"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040133">
        <property type="entry name" value="SNCAIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032027">
        <property type="entry name" value="SNCAIP_SNCA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22882">
        <property type="entry name" value="SYNPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22882:SF3">
        <property type="entry name" value="SYNPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16700">
        <property type="entry name" value="SNCAIP_SNCA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Synphilin-1 alpha-Synuclein-binding" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB66230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="920" mass="101696" checksum="89A5ED106B26CDFC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0J3</accession>
    <name>A0A401P0J3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0013599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007018">
        <property type="protein sequence ID" value="GCB66631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0J3"/>
    <dbReference type="STRING" id="75743.A0A401P0J3"/>
    <dbReference type="OMA" id="LSMMNHY"/>
    <dbReference type="OrthoDB" id="302770at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12689">
        <property type="entry name" value="RRM1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12785">
        <property type="entry name" value="RRM2_hnRNPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12699">
        <property type="entry name" value="RRM3_hnRNPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12704">
        <property type="entry name" value="RRM4_hnRNPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000072">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein L isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000052">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein L like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000073">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein L like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034816">
        <property type="entry name" value="hnRNP-L_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035008">
        <property type="entry name" value="hnRNPL_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034817">
        <property type="entry name" value="hnRNPL_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019404109" description="RRM domain-containing protein" evidence="9">
        <location>
            <begin position="28"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB66631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="557" mass="61486" checksum="BC1480D03C7A327D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1J9</accession>
    <name>A0A401P1J9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Catenin alpha-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Alpha N-catenin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0013644</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
            <location evidence="5">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007065">
        <property type="protein sequence ID" value="GCB67002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1J9"/>
    <dbReference type="STRING" id="75743.A0A401P1J9"/>
    <dbReference type="OMA" id="TIAPHCH"/>
    <dbReference type="OrthoDB" id="6376697at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF23">
        <property type="entry name" value="CATENIN ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB67002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="154" mass="17099" checksum="8C442BFCCA32B2F2" modified="2019-05-08" version="1" fragment="single">EKSGMDWSRQTSCQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEYQTRVRRGSQKKHISPVQALSEFKAMDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1Q9</accession>
    <name>A0A401P1Q9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002987">
        <property type="protein sequence ID" value="GCB67062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1Q9"/>
    <dbReference type="OMA" id="GMQDAEP"/>
    <dbReference type="OrthoDB" id="9950769at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.620">
        <property type="entry name" value="Helix Hairpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="249" mass="28351" checksum="3B18B3D3E48B376A" modified="2019-05-08" version="1">MREGCRAGPAGSGPRPHDADPELQDAERDEQDAQPDLQDAEQDLQNAEPDLHVAEPEQQDVDPDLQDEERDLQDGEPDLQDGERDLQEAEWDLQEAERDLEDAGWDLEDAGWDLEDAERDLQDAEPDLEDAERDREDARRDLEDAGRGMQDAEPYPQDAEPDLEDAERDREDAGRDLEDAGRGMQDAEPYLQDTEPDLQDAEWDRKEAERDLEDAGRCLQYGEWDLMDGGPDLQDAERDLQDAELICLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1Z9</accession>
    <name>A0A401P1Z9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008386">
        <property type="protein sequence ID" value="GCB67154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1Z9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10667" checksum="0BE39CCE1293D5E9" modified="2019-05-08" version="1">MDFIGFQEIQEANENLKAIQYKGGFLNYYDSADQLEVQLEDFLQLLTHCHVDNSFLTLAFKDKEDTEGPKEIIWVSKCHLATKVVFLKLILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2A6</accession>
    <name>A0A401P2A6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/arginine repetitive matrix protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004363">
        <property type="protein sequence ID" value="GCB67268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2A6"/>
    <dbReference type="STRING" id="75743.A0A401P2A6"/>
    <dbReference type="OMA" id="KDNERNG"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029360">
        <property type="entry name" value="SRRM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15230">
        <property type="entry name" value="SRRM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/arginine repetitive matrix protein C-terminal" evidence="2">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="415" mass="47051" checksum="345539E4E6343816" modified="2019-05-08" version="1">MKHSWGILHPCLICIDLSCRSTTPKCKRKDRSKQRKRSPSESPPRKSHKGRSCCSSRSISASSVRSSSKSLSSCHSPSSEPRTSHAKNKQSAMSRQSPKNDTNGRKPSCTRSSPNQSPLRVRHRRSVTPRQNGHKGASWNGRQSPRHRHPPDRSQDSTDSRSLSPGAEPRSASTSPKAKDSKRSKHGSRSFRSRSPGHSRRSSAEGRHAKHRSRLRQTSDRHHRSHFTSRNKSRTRSPGKREQPSSHNSDKKKSSSYSPRRKSSSRSSSRSMSRSCSRSHDKRDGRSKSRSSPRKEQSRERDGKVGARHHDSEAERHHRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSPSSLSYSSYSSRSRSRSYDSYSSYSRSGTRSPSRSGTRSRTASYDSRSSSESIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P363</accession>
    <name>A0A401P363_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sulfotransferase</fullName>
            <ecNumber evidence="13">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0015129</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.</text>
            <dbReference type="EC" id="2.8.2.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chondroitin beta-D-glucuronate + n 3'-phosphoadenylyl sulfate = chondroitin 6'-sulfate + n adenosine 3',5'-bisphosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:11108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9827"/>
            <dbReference type="Rhea" id="RHEA-COMP:9828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57652"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:62065"/>
            <dbReference type="EC" id="2.8.2.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11109"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="13"/>
    <dbReference type="EMBL" id="BFAA01008430">
        <property type="protein sequence ID" value="GCB67562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P363"/>
    <dbReference type="STRING" id="75743.A0A401P363"/>
    <dbReference type="OMA" id="KWRFGMP"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008459">
        <property type="term" value="F:chondroitin 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045130">
        <property type="term" value="F:keratan sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000938">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF60">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019006817" description="Sulfotransferase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="15">
        <location>
            <begin position="91"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB67562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="438" mass="49922" checksum="BFCE0270C672E6C3" modified="2019-05-08" version="1">MRMRSKYAIILFFVAALVIIEKENNIISRVSDKLILKFPQGEFAGLNNTISARALTENDSLLTGTSSSLLNCASSQAGPKREDSKEPTGRKHLILMATTRTGSSFVGEFFNQNSNIFYLFEPLWHVERTVTFEPKGANAVATSIVYRDVVQRLMLCDMYALENFLLPLPIQHVTAFLFRRGSSKSLCEKPVCTPPPRTKYPWHERFPCRLHRCGLLNMTLAMHACLQKQHVAMKTVRLRQLDFLRPLMEDFRINLKVIQLVRDPRAVLASRMVAFPSKYEAWKKWANQGVVPDDEEVGKLRGNCENLRTSAQLGLSQPAWLKDRFMLMRYEDVALEPMKKAYEMYRFAGIPITPEVKMWIYTNTQTSQGSDNLYSTRKNSSEQFEKWRLALPFKIAQVVQTVCGPAMKLFGYKLAKDAETLANRSASLLEDRGSLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P549</accession>
    <name>A0A401P549_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear receptor coactivator 4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0008201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003094">
        <property type="protein sequence ID" value="GCB68271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P549"/>
    <dbReference type="STRING" id="75743.A0A401P549"/>
    <dbReference type="OMA" id="FPPDCYG"/>
    <dbReference type="OrthoDB" id="6334544at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039947">
        <property type="entry name" value="NCoA-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022174">
        <property type="entry name" value="NCOA4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17085">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17085:SF3">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12489">
        <property type="entry name" value="ARA70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear receptor coactivator 4 N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor coactivator 4 N-terminal" evidence="3">
        <location>
            <begin position="340"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB68271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="696" mass="78372" checksum="041171579097716F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6G1</accession>
    <name>A0A401P6G1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0005355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001656">
        <property type="protein sequence ID" value="GCB68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6G1"/>
    <dbReference type="STRING" id="75743.A0A401P6G1"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17187">
        <property type="entry name" value="FERM_F1_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000003">
        <property type="entry name" value="Radixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.450:FF:000001">
        <property type="entry name" value="radixin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="603" mass="71470" checksum="33B7E69C4480F1FC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6R7</accession>
    <name>A0A401P6R7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003141">
        <property type="protein sequence ID" value="GCB68814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6R7"/>
    <dbReference type="STRING" id="75743.A0A401P6R7"/>
    <dbReference type="OMA" id="RAPCDFL"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF36">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="110"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB68814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="290" mass="32589" checksum="D4901F0EA85E0B5E" modified="2019-05-08" version="1">MAFDVRRLDIYRKVPRDLTQPTYTGAFISICCCVFMLFLFLSELTGFIATEIVNELYVDDPDKDSGGKIEVNLNISLPNLSCDVVGLDIQDEMGRHEVGHIDNSMKLPLNNGKGCRFEGQFSINKVPGNFHVSTHSATAQPDSPDMTHVVNKLTFGEIIEVKNVQAAFNALARADKRSSNPLASHDYVVKIVPTVYEDLKANQRFSYQYTVAQKEYVAYSHTGRIIPAIWFRYDLSPITVKYVERQQPLYRFITTICAIIGGTFTVAGIIDSCIFTASEAWKKIQLGKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7C2</accession>
    <name>A0A401P7C2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0008316</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01003154">
        <property type="protein sequence ID" value="GCB69008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7C2"/>
    <dbReference type="STRING" id="75743.A0A401P7C2"/>
    <dbReference type="OMA" id="GAMKATY"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14091">
        <property type="entry name" value="STKc_RSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000041">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000121">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="212"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="308"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB69008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="626" mass="71034" checksum="932E5287AAC3B277" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P848</accession>
    <name>A0A401P848_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0010536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004567">
        <property type="protein sequence ID" value="GCB69315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P848"/>
    <dbReference type="OMA" id="QFLADTC"/>
    <dbReference type="OrthoDB" id="6103133at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF2">
        <property type="entry name" value="SIMILAR TO 4930578I06RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB69315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="262" mass="30566" checksum="CD7987EAF33CC1E4" modified="2019-05-08" version="1" fragment="single">KEDGRCHLIKLLKWEDFDEEKDLKPGIILDYLYNTIIFAAEKGFPWPSVAVAVCFSEELLYETEGQTMQEALRKLRDKCEEYQLKLNPNYLQHLVNHLMGTFFKHYRLYQFVLCEDREIDQTIYDLVVQIPHEAPSLKGGVSAELWKYQKQITELSEAEDQLRASMAALRETMQLKSEQKLEKFYEDLKFQDKEVIERANLEKIIKDAHEIQMSVASELLQKVIETAFQILDLKIQKTTISLPATKSPATKETKTGRMGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8E3</accession>
    <name>A0A401P8E3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calcium channel subunit alpha-2/delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004578">
        <property type="protein sequence ID" value="GCB69419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8E3"/>
    <dbReference type="STRING" id="75743.A0A401P8E3"/>
    <dbReference type="OMA" id="HRCISCT"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990454">
        <property type="term" value="C:L-type voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000014">
        <property type="entry name" value="voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF6">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB69419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="404" mass="45876" checksum="34251DA6E0A016AA" modified="2019-05-08" version="1" fragment="single">FNNQAKSVSCFRHLVQANVRNKKVLKDAVNQIQAKGITDYKKGFTFAFEQLLNFNVSRANCNKIIMLFTDGGEERAQEIFTTYNQEKKVRVFTFSVGQHNYDKGPLQWMACTNKGYFFEIPSIGAIRINTQEYLDVLGRPMVLAGTNEKQVQWTNVYLDALELGLVITGTLPVFNLTKDASGNQNQLILGVMGIDVSLADVQRLTPRYTLGPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENEIKVEIRHSMIEGQNGERTLDTLIKSYDERYIDKGTRTYTWTLVNSTDYSLALVLPPYGFHYIKAKLDEVITQAKHLESIMPDNFETTGYVYLAPREYCNGLPPSNNNTAFLENFINFIDRQTPNSPDSLPIMWNAATVIAFIEDAPSWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8S0</accession>
    <name>A0A401P8S0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0010575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004593">
        <property type="protein sequence ID" value="GCB69545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8S0"/>
    <dbReference type="STRING" id="75743.A0A401P8S0"/>
    <dbReference type="OMA" id="XVASVCE"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF31">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="291" mass="32698" checksum="51C4D990A6F66427" modified="2019-05-08" version="1">MVFRSQLEVYSALSLLPNSAERAFFLLANCRAQDELSMFQLPTINFTPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAVGQSGGCTLSEPGCPPHSAAESPSTAASPTTSVSSLTERAETATSILSVTSSDSECDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9Q7</accession>
    <name>A0A401P9Q7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003237">
        <property type="protein sequence ID" value="GCB69832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9Q7"/>
    <dbReference type="STRING" id="75743.A0A401P9Q7"/>
    <dbReference type="OMA" id="PALCHCH"/>
    <dbReference type="OrthoDB" id="2190652at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000059">
        <property type="entry name" value="Chondroadherin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019109254" description="LRRNT domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="11">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB69832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="257" mass="29159" checksum="D6B3ABC5E78B939A" modified="2019-05-08" version="1" fragment="single">MHQLSWLLLAPLLAMGTAAPRCPSGCHCLGDLLHVVCENKGLKKIPRVPNKVRLLSLQQNHYPILPSNGFSSMKSLVSLHLQECHIQEISSKAFRGLKKLVYLYMSKNEITTIRPGAFQDLSQLTYLYLDNNRISELAKGLLTPLKSLFLLQLTSNRMHQIRPGTFAGAKELRWLHLSDNDMTTILPGALDDVENLATLHLDKNKLNTYPAVALSKLRVVEELKLSFNNIRTIPDNAFRSFGRYVERMWLNNMGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAS2</accession>
    <name>A0A401PAS2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Inositol polyphosphate-4-phosphatase type I A</fullName>
            <ecNumber evidence="8">3.1.3.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Inositol polyphosphate 4-phosphatase type I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Type I inositol 3,4-bisphosphate 4-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0005632</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:43389"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Signal transduction; phosphatidylinositol signaling pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with INPP5F.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Recycling endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.66" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01001780">
        <property type="protein sequence ID" value="GCB70226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAS2"/>
    <dbReference type="STRING" id="75743.A0A401PAS2"/>
    <dbReference type="OMA" id="SHPACTD"/>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="UniPathway" id="UPA00944"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000038">
        <property type="entry name" value="Type I inositol 3,4-bisphosphate 4-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF4">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-4-PHOSPHATASE TYPE I A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="C2" evidence="25">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB70226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="932" mass="105043" checksum="96FDDC0115E93DB3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBI0</accession>
    <name>A0A401PBI0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0008592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003324">
        <property type="protein sequence ID" value="GCB70486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBI0"/>
    <dbReference type="STRING" id="75743.A0A401PBI0"/>
    <dbReference type="OMA" id="FSEHFQY"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004666">
        <property type="term" value="F:prostaglandin-endoperoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019371">
        <property type="term" value="P:cyclooxygenase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09816">
        <property type="entry name" value="prostaglandin_endoperoxide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF6">
        <property type="entry name" value="PROSTAGLANDIN G_H SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="For cyclooxygenase activity" evidence="11">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB70486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="531" mass="61554" checksum="EEC7E28909A85A58" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBU1</accession>
    <name>A0A401PBU1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thrombospondin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003340">
        <property type="protein sequence ID" value="GCB70587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBU1"/>
    <dbReference type="STRING" id="75743.A0A401PBU1"/>
    <dbReference type="OMA" id="PANENPG"/>
    <dbReference type="OrthoDB" id="10060752at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000039">
        <property type="entry name" value="Collagen XV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="268" mass="29341" checksum="F4E70EC0C0CB7FB1" modified="2019-05-08" version="1">MLGVESMQLPELFITLSGWEEFSFAVGAGIGPVGMLYNYYSVSLLQLLGDPAPEQVAIEYIPDQNPVYRFGPNVNTGQLARAYFQSPFFRDFSLLFTVKPTTVQSGVLFAITDASQLIIYIGVKLSEVRDESQDVIFFYTEPGSQESNEAASFRVKHLTNKWTKIAIGVVGETVSLYLDCELQGVAYFERSPDEMEIDKTSGVFVALAGGADPDHFLGFISDLKVTGDPLAARLYCEDDDDGEASGDYGSGYGRGTQTVISLKPRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD45</accession>
    <name>A0A401PD45_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cathepsin propeptide inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003399">
        <property type="protein sequence ID" value="GCB71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD45"/>
    <dbReference type="STRING" id="75743.A0A401PD45"/>
    <dbReference type="OrthoDB" id="5855924at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="2">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="122" mass="14194" checksum="431D9199411ACA60" modified="2019-05-08" version="1">MRQPDCLSVFIQEEETYRRKIWEDNVRYIEQHNLEYSMGKHTFTVGMNPLGDLVADNSTEEFEGDEFDEDEESDGDDELDKESDGADDELDEESDDDVTPVNVDWRKRGVVTPVKNQMPNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEK6</accession>
    <name>A0A401PEK6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0008880</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003495">
        <property type="protein sequence ID" value="GCB71590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEK6"/>
    <dbReference type="STRING" id="75743.A0A401PEK6"/>
    <dbReference type="OMA" id="ESCMFNA"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.110:FF:000001">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="16 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="294"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="517"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="624"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB71590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="708" mass="80485" checksum="16BF896865E6811D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFE4</accession>
    <name>A0A401PFE4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0001712</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000395">
        <property type="protein sequence ID" value="GCB71819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFE4"/>
    <dbReference type="STRING" id="75743.A0A401PFE4"/>
    <dbReference type="OMA" id="MITISWR"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042497">
        <property type="term" value="F:triacyl lipopeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF17">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="124"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB71819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="295" mass="34895" checksum="8A39FBA2496701D1" modified="2019-05-08" version="1">MHSSQSLDLVELKFSNNPFECFCEIQTVFNYVQQAQTAILEWPNQYQCDRPQKFKGQAIQFLKFSPIECKIPLFVGVLLACVVLLVAVCIMLCIKYNVTWYIRTLWLWLKAKRAVDVSLVENKFEYNAFISYSEYDSSWVKDVLLAQLENSDPPCRICIHERDFKPGKSIINNIIDCISKSYKTIFILSKHFVQSEWCHYELFFAHQQVFDDKKDSLILLLLEPIPKNSIPDRFCKLRKLMNRNTYLEWPQNEFQRGFFWKRLKAVLNLDFHSCSSQVTQQEIIQIPDLIPEHHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGB1</accession>
    <name>A0A401PGB1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0001848</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="BFAA01000429">
        <property type="protein sequence ID" value="GCB72151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGB1"/>
    <dbReference type="STRING" id="75743.A0A401PGB1"/>
    <dbReference type="OMA" id="XVYFIAT"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
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        <property type="entry name" value="Phospholipid-transporting ATPase"/>
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        <property type="entry name" value="Phospholipid-transporting ATPase"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
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    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
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    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
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    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF49">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="143"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="810"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="391"/>
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        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="675"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="676"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="677"/>
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        <ligand>
            <name>ATP</name>
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            <position position="757"/>
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            <name>ATP</name>
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        <location>
            <position position="763"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="783"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <position position="786"/>
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            <name>ATP</name>
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            <name>ATP</name>
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            <position position="787"/>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB72151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1029" mass="116439" checksum="1F48341CDAA2B12D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGY5</accession>
    <name>A0A401PGY5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0001973</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000462">
        <property type="protein sequence ID" value="GCB72396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGY5"/>
    <dbReference type="STRING" id="75743.A0A401PGY5"/>
    <dbReference type="OMA" id="GEYISTW"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01241">
        <property type="entry name" value="PH_PKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000551">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000027">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000838">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039026">
        <property type="entry name" value="PH_PKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="48"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="177"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB72396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41681" checksum="2EB827EE570D6ADC" modified="2019-05-08" version="1" fragment="single">MAKDEDCLATFWMERKGGSDVLYIPVPGSNQWTIHCYKLEACKGEYIKNWRPRYFLLKADGSFIGYKEKPQDADLPYPLNNFSVAKCQLMKTERPRPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQKQEEDRMNCSSSPNLDITGEDEMDTSLSHPKRKVTMNDFDYLKLLGKGTFGKVILVKEKATGKYYAMKILKKEIIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSEKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEGCQRTKDPAMVSDPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKU6</accession>
    <name>A0A401PKU6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000729">
        <property type="protein sequence ID" value="GCB73757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKU6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8208" checksum="84168F9B61D99964" modified="2019-05-08" version="1">MALGVVTASFNLAPRCTLSEEIYYTNKNEQGTIRRVVRHVLQLFGFAFDFPALLSLAFGPNMVDYGFETAQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PL59</accession>
    <name>A0A401PL59_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anoctamin dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000765">
        <property type="protein sequence ID" value="GCB73859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PL59"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anoctamin dimerisation" evidence="2">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="99" mass="11530" checksum="7CEEE5758A07C4EF" modified="2019-05-08" version="1">MGSEEELQVTDYVLVCEKNTVQPYARQRLDFLREVKRAGLTLDPDPDRQQAETLREGEMVHDDNKPKEQNQIIKIYAPFEILSQAAEKMRLKMPLDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP94</accession>
    <name>A0A401PP94_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013619">
        <property type="protein sequence ID" value="GCB74939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP94"/>
    <dbReference type="OrthoDB" id="10425348at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="58" mass="6911" checksum="BB5834730BD346B1" modified="2019-05-08" version="1" fragment="single">HEYARTVEEIKCLDPYNNVQAEATTKKVFKDVYGLPDTYRWKTEYDSSYNMNPDGTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRT1</accession>
    <name>A0A401PRT1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011262">
        <property type="protein sequence ID" value="GCB75846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRT1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10121" checksum="662E795AC8B71A90" modified="2019-05-08" version="1">MDSGLKPEKLNLDARSSEATEIFKYWLRCFEAYLNSSETEVDGPRKLSLLHARVGHRQSSVIEKAMTIDVTKTTEAKFNNKAVSFQKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSK1</accession>
    <name>A0A401PSK1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0020437</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016498">
        <property type="protein sequence ID" value="GCB76104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSK1"/>
    <dbReference type="STRING" id="75743.A0A401PSK1"/>
    <dbReference type="OMA" id="ECVKYQV"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002520">
        <property type="term" value="P:immune system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030856">
        <property type="term" value="P:regulation of epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016374">
        <property type="entry name" value="TF_GATA-2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF106">
        <property type="entry name" value="TRANS-ACTING T-CELL-SPECIFIC TRANSCRIPTION FACTOR GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003027">
        <property type="entry name" value="TF_GATA-1/2/3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="257"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 1" evidence="11">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 2" evidence="11">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR003027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB76104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="448" mass="48426" checksum="96E1EE133B86B0EE" modified="2019-05-08" version="1">MEVDQPRWMTHHHPAVLNGQHPDSHHPGLSHGYVDSAPYLQSEEVDVLFNIDSQANHVASYYGNSVRATVQRYPPPHHGGQVCRPPLLHGSLSWLDGGKALASHHNASPWNLSAFSKAPLHHSSPGALSVYPPSSSASLSAGHSSPHLFTFPPTPPKDVSPDPTLSAPGPSSSSRLEDKECIKYQVSLAEGMKLETGSSHPRSSMTLGGCSAAAHHPLASYPPYVPDYSSSLFPSSSLLGGSPPGFHSKARPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKSKKTHDGLDEFSKSLMDKASSFSPTALSRHMSPIHHIPPFSHSGHMLSTPTPMHPPSSLSFGPHHPSSMVTAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT70</accession>
    <name>A0A401PT70_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0018330</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the LRFN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012660">
        <property type="protein sequence ID" value="GCB76346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT70"/>
    <dbReference type="STRING" id="75743.A0A401PT70"/>
    <dbReference type="OMA" id="ATTCYSY"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000045">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000091">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000019">
        <property type="entry name" value="leucine-rich repeat and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019137185" description="Ig-like domain-containing protein" evidence="18">
        <location>
            <begin position="21"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="289"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="416"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="592"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB76346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="81458" checksum="0B4A7B7345B3F26D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUQ5</accession>
    <name>A0A401PUQ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008878">
        <property type="protein sequence ID" value="GCB76838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUQ5"/>
    <dbReference type="STRING" id="75743.A0A401PUQ5"/>
    <dbReference type="OMA" id="FESEEYV"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001927">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB76838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="18042" checksum="72C64545DF307D47" modified="2019-05-08" version="1">MTYLEEKCYIHRDLRTENILLTEMLSCKIADFGLARLLENGQCRLSLDIKVPIKWMAPEIFINNIYTTKSDVWSFGVLLTEIVTFGDMPFPDKENTEFVKDLMNGVMPPPAGCPESFHDMMLQCWEQESEKRPTFKQLQNTLMKCNPVPETEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWF3</accession>
    <name>A0A401PWF3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Perilipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016823">
        <property type="protein sequence ID" value="GCB77467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWF3"/>
    <dbReference type="STRING" id="75743.A0A401PWF3"/>
    <dbReference type="OMA" id="VMFRGIT"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.170">
        <property type="entry name" value="Perilipin, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF11">
        <property type="entry name" value="PERILIPIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB77467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="393" mass="42984" checksum="ED2EF39AD9329950" modified="2019-05-08" version="1">MVSAVYNSTKENHPYVKTVCDVAEQGVKTISAVAVSGAKPIIDQLEPQITAANEYACKGLDKLEEKLPILQQSTPQIVADTKELVSSTITGAKDAVSNTVTGVVDMAKGAVHGSIEKTKIVMAEGVNTVMASKVGQMVVTGVDSALNKSEEMVDHYLPMTEEELAKLATSVEGVEVAPAPLQSYYVRLGSLSSKVRHRAYQHSTSKMQEARQSSQDTMAQLHNTMDLIELAKKGVDSANQKLHEVREKLHQTWADWQKKQPKGQAEEEEGTQKPGQLESQTLSMTRSLTQQLQTTCLTLVSNVHGLPQHIQDKMQQIRSTAETIHSSFSAANSFGDLSGQLLVQSREQMLKIRESMDGVMDYVLHNTPLNWLVGPFAPQLTESEAIAMDVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWY4</accession>
    <name>A0A401PWY4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016845">
        <property type="protein sequence ID" value="GCB77563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWY4"/>
    <dbReference type="STRING" id="75743.A0A401PWY4"/>
    <dbReference type="OrthoDB" id="5988548at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23440">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000029">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="35"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="17559" checksum="6BC24C4C989B8DC0" modified="2019-05-08" version="1">MCAESIPAAAGDPAKLGDVNINIGLGLDVIYLRANGLGEIRHLQTAKCISAQNHPSQKAGIVVVKECDLSDPDQIWVYDEEHELVLANLLCLDMAETRLSDSPRLMKCHGSGGSQQWTLGKNNRIYQVSAGQCLQVVDPADIKGYIAIAICDGSAAQQWQIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWZ3</accession>
    <name>A0A401PWZ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0015694</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="BFAA01009016">
        <property type="protein sequence ID" value="GCB77640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWZ3"/>
    <dbReference type="STRING" id="75743.A0A401PWZ3"/>
    <dbReference type="OMA" id="HEAANQY"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03068">
        <property type="entry name" value="PDI_b_ERp72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000067">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000076">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000084">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000126">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041866">
        <property type="entry name" value="PDIA4_PDI_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF210">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="368"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="418"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB77640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="508" mass="57847" checksum="B8991A7B184BBC4D" modified="2019-05-08" version="1">MEPRTRSGARGKELLEQESLRELLSKVKEVASPDWIPPAEATIVLTEDNFDDVVNDAAIILVEFYAPWCGHCKKFAPQYEEAAEELGKRSVPILLAKVDATTETQLANKYQVTGYPTLKIFRKGKPFEYNGPRDTEGIIDHMIEQAGPPSKQIQALKQVQEFLKDGDDVIIIGIFSGEKDPSYLTYQDACNSVREDYRLHHTFSSEIQNYLKVSPGQLVMMQPEKFNSEYEPKMHTLTIKDILPHSEVTDFITNNAVPLVGHRKQSNDAKRYSKRPLVVVYYGVDFSFDYRVATLYWRKKVLDVAKDFPDYTFAIADEEDYSSELNSLGLADSGEEVNVAILDVAGKKYAMEPEEFDSDILREFVMAFKKGKLKPIVKSQPVPKNNKGPVKVVVGKTFDEIVMDKKKDVLIEFYAPWCGHCKKLEPVYLELGKKYKNEEQLIIAKMDAAANDVPNDKYKTEGYPTIYFAPSNNKDNPIQFDQNERDLDSLSKFVEEHATKLSRSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXB4</accession>
    <name>A0A401PXB4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0019323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014261">
        <property type="protein sequence ID" value="GCB77779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXB4"/>
    <dbReference type="STRING" id="75743.A0A401PXB4"/>
    <dbReference type="OMA" id="FRYYDFF"/>
    <dbReference type="OrthoDB" id="10055806at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB77779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="243" mass="26709" checksum="40A6342874818BEC" modified="2019-05-08" version="1" fragment="single">AGRLKVKCKEERVMAKAGEDDVIQCQLYSRNKVGSVAFVWKKEDAAEIIYNYTASRGNRGQNPSYRDRAQVFDNEIPKGNVSLRLRNVTLSDSGTYSLSVASRSQRIQTQVFLRIRAVGTPPVIHSPSDDLGLVVLVCESSGWYPAPSVSWENGLGENLTRYSHTELTNCTGGSVCVKSTLEMDNWPSGNYTCSIWNQELDEGLSSSFILIHRVPLVGGNEQGIRLGFCGCPCAIVSLKTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXC3</accession>
    <name>A0A401PXC3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015572">
        <property type="protein sequence ID" value="GCB77693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXC3"/>
    <dbReference type="STRING" id="75743.A0A401PXC3"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17133">
        <property type="entry name" value="RBD_ARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000015">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RBD" evidence="2">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="159" mass="17235" checksum="33B80B5E6BB96198" modified="2019-05-08" version="1" fragment="single">MKRVSASSPALSNGYGLPSLIISTVHSTPSGGQEQQPYQRTPLAHSPGEMPRATGTVRVYLPNKQRTVVNVREGMTVNDSLDKALKVRGLSQKCCAVYRFIDGHKKLTDWGTDITPLVGEELMVEVLDEVPLSMHNFVSLALEIGVCPLVVDGQTIHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXF3</accession>
    <name>A0A401PXF3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 1B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0016734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010314">
        <property type="protein sequence ID" value="GCB77723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXF3"/>
    <dbReference type="STRING" id="75743.A0A401PXF3"/>
    <dbReference type="OMA" id="STFMQWI"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20675">
        <property type="entry name" value="CYP1B1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000002">
        <property type="entry name" value="Cytochrome P450 1A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF15">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 1 SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB77723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58584" checksum="DB512275AF91BCF3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401PYL3_SCYTO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
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                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
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                <person name="Tanegashima C"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="GCB78212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="43" mass="5209" checksum="5EC44DAC2DD723F0" modified="2019-05-08" version="1" fragment="single">CPEIPGELECLWDIRWMVKYAADSTRIHGRLNCELRWMNNMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="3 4">
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        <name type="common">Cloudy catshark</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
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                <person name="Tatsumi K"/>
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                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="72220" checksum="3D78672ECC909726" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB78405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="175" mass="20192" checksum="24772F4217DD8304" modified="2019-05-08" version="1" fragment="single">GDIQQLLIVPDHRAAYDYCEHYNPDCDNPLPDSLQSQDPNLDEYDNPGESYYYEYPYYEELPDDYKEPPTDTIPEYGEQITGPVTAVPEYPESGTEAEDEVFVETTVTIPEAITAEYPSVVTSYYDIYGGDYYYSLVDDKDDVVSERDWRENQVKVDLCGLEMGNSRVHRKKFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZN9</accession>
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            <fullName evidence="6">CBS domain-containing protein</fullName>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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                <person name="Nozu R"/>
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                <person name="Nishida K"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12606" checksum="BA7649D7B91225B5" modified="2019-05-08" version="1">MKPEVQGSAEGMLEKLELEDEAEESDSDIYMRFMKSHKCYDIVPTSSKLVVFDTSLQVKKAFFALVANGVRAAPLWETKKQSFVENRTCKRKSRRKICNGLLAGWRDMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0Q6</accession>
    <name>A0A401Q0Q6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011887">
        <property type="protein sequence ID" value="GCB78944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0Q6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10204" checksum="20535570B33BF7B1" modified="2019-05-08" version="1">MNGSSQPPMAKAAEVVGKAEEAGTKETEAMSPTLLAVFSGNGENKPELYSAAKCKLLHRHYSDAHEHCTFLYPSLFGKLEKMFFEQLLFSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0U7</accession>
    <name>A0A401Q0U7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015902">
        <property type="protein sequence ID" value="GCB79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0U7"/>
    <dbReference type="STRING" id="75743.A0A401Q0U7"/>
    <dbReference type="OMA" id="SYNIWIF"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF8">
        <property type="entry name" value="PROTEIN SLC31A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="16043" checksum="9CF29EAC1CCAAE7E" modified="2019-05-08" version="1">MHMHFFVSDQVILLFDFWNVHSVAGMVLTVVIVLLMTVSYEMLKVETVKLDQKILDLMTATPNVQDETAETLPINPNARNTSDKRWIWVHVLQSLLHIIQVVLSYLLMLCAMSYNVWVFLSIIAGAGIGYFVAHPLIKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0Z0</accession>
    <name>A0A401Q0Z0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0020169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015908">
        <property type="protein sequence ID" value="GCB79045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0Z0"/>
    <dbReference type="STRING" id="75743.A0A401Q0Z0"/>
    <dbReference type="OMA" id="HSMPKYN"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010542">
        <property type="entry name" value="Vert_HSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF274">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06546">
        <property type="entry name" value="Vert_HS_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="11">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB79045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="314" mass="35330" checksum="BF8F124D856E4BE9" modified="2019-05-08" version="1" fragment="single">SGNSFHVFDQGRFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVNIEQGGLVKPEKDDTEFQHVYFIRGQEHLLENIKRKVTSMSTVKPEEIKVRSDDVSKILTDVQIMKGKQENLDSKLHNMKHENEALWREVASLRQKHTQQQKVVNKLIQFLISLVQSNRVIGVKRKIPLMLNDSSSAHSMPKYNRPYSLEPLQESSPLTTSTNFPGNNCYSSDNSTSSGPIISDITDLAQCNPSLAPSLNVERASPLIHIKEEPPSPTTNPEIEEVSPVVSGTEEPLSPSTFIDSILEDNETSTAQPPPEDRCLSVACLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1B3</accession>
    <name>A0A401Q1B3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-X-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0017852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the intercrine alpha (chemokine CxC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011945">
        <property type="protein sequence ID" value="GCB79187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1B3"/>
    <dbReference type="STRING" id="75743.A0A401Q1B3"/>
    <dbReference type="OMA" id="PSCANVE"/>
    <dbReference type="OrthoDB" id="9937393at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00273">
        <property type="entry name" value="Chemokine_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000004">
        <property type="entry name" value="C-X-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001089">
        <property type="entry name" value="Chemokine_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018048">
        <property type="entry name" value="Chemokine_CXC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033899">
        <property type="entry name" value="CXC_Chemokine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF198">
        <property type="entry name" value="PLATELET BASIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00436">
        <property type="entry name" value="INTERLEUKIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00437">
        <property type="entry name" value="SMALLCYTKCXC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00471">
        <property type="entry name" value="SMALL_CYTOKINES_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3 6" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018819438" description="C-X-C motif chemokine" evidence="6">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB79187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="11495" checksum="7E12ADEC265DF553" modified="2019-05-08" version="1">MNGKVALFSLTLFVLYVASLQAASIGRTGMSLRCQCIKTSSKFIHPKFMENIDIIPSGPHCENVEIIATLQSTNRVCLNPDSAWVKKIINRIISRSKKNDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2K5</accession>
    <name>A0A401Q2K5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013398">
        <property type="protein sequence ID" value="GCB79622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2K5"/>
    <dbReference type="STRING" id="75743.A0A401Q2K5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000046">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 1 isoform x2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000056">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF209">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB79622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="18044" checksum="3A950422336E766A" modified="2019-05-08" version="1" fragment="single">DYARLCNLPVPGRRHEYGQDALLPPYQPDYSVPSSEYDSRQSLRGNQPFFVDGRYPFDSFEGLQAEECGILNGCENGRCVRVQEGYTCDCYDGYQLDIAKLECVDVNECIELNDKMSLCRNAKCINTDGSYKCVCLPGYAPSEQPNYCVTAETEKEAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3D3</accession>
    <name>A0A401Q3D3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013469">
        <property type="protein sequence ID" value="GCB79850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3D3"/>
    <dbReference type="STRING" id="75743.A0A401Q3D3"/>
    <dbReference type="OrthoDB" id="7103806at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042476">
        <property type="entry name" value="APPBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575:SF1">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10277" checksum="607E3C7345C8571D" modified="2019-05-08" version="1">MEFNRLHSVSAWIELWLRSGSPGVRWLWFSLTPFAPLMTALDIRHSVSGGKNIHVATAHEDLAYPYAHQSGKFDIALFHAEHAIDIITQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4C0</accession>
    <name>A0A401Q4C0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009548">
        <property type="protein sequence ID" value="GCB80214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4C0"/>
    <dbReference type="OMA" id="AQCQLDT"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001:SF3">
        <property type="entry name" value="RIBOSOME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="286" mass="30825" checksum="7DBC2C828C1C61C7" modified="2019-05-08" version="1" fragment="single">LGNVKLGNIKLGNIRLGNIRLGNVKLGNVRLGNVKLGNVRLGNIRLGNVRLGNVRLGNVRLGNIRLGNVRLGNVKLGNVRLGNVRLGNVRLGNIRLGNVRLGNVRLGGVKLGNVKLGNIRLGNIRLGNVRLGNVKLGNVKLGNVRLGNIRLGNVRLGNVKLGNVRLGNVKLGNVRLGNISPAPRDALQTQLFVTDPIGMKMFLDNKSQIEVEIAQKKTTAPRMSLNGRIRPSAETGGFGDLKHLQGFCGVAPSQGAELGRCQNGTLAHRQYIGHCEEFIPIIKQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4V6</accession>
    <name>A0A401Q4V6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010936">
        <property type="protein sequence ID" value="GCB80400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4V6"/>
    <dbReference type="STRING" id="75743.A0A401Q4V6"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10418" checksum="5CFA4261359DF9ED" modified="2019-05-08" version="1" fragment="single">TLLILKTPYPRKVDEPSIYESVRVHTAMQSGRTENDLIAEAPSLGTKEGYLTKQGGRVKSWKTRWFILHRNELKYFKDKMVSVERNCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q508</accession>
    <name>A0A401Q508_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Insulin-induced gene 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0017183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010960">
        <property type="protein sequence ID" value="GCB80455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q508"/>
    <dbReference type="STRING" id="75743.A0A401Q508"/>
    <dbReference type="OMA" id="ENHTWSC"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032937">
        <property type="term" value="C:SREBP-SCAP-Insig complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036316">
        <property type="term" value="P:SREBP-SCAP complex retention in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF11">
        <property type="entry name" value="INSULIN-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB80455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="257" mass="28383" checksum="FBA960D888B17987" modified="2019-05-08" version="1">MSRIEEACWSCSCTRVRPSESNGTLLVAKVHEMMTIVSSILGSAYCSLVSGHTMNLVRRGLVLFTVGVFLALVLNLLQIQRHVTLFPEEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDRHLGEPHKFKREWASVMRCVAVFVGINHASAKLDFANNMQLSLTLAALSLGLWWTFDRSRSGFGLGLTIAFVATLVTQLLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVSEITHKDCLDKMHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5Q6</accession>
    <name>A0A401Q5Q6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009808">
        <property type="protein sequence ID" value="GCB80688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5Q6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="22895" checksum="5673574BA64A9D09" modified="2019-05-08" version="1">MTYSNYTKRGVVCELPGHNVALINLSESITIGHPELTPYRDVSIVDADDLERTDDDQRIHRYVQKGLPRVRVDWEGQEKEATQIDHLWNKEHELINTHAEKAEELFKSQNFFSKIWNWELNTNIHPWIRIISHIVVILQLFILLVFFITLCYLRRRIREWRKDSCPLDKEKLTILHFGLNPTNSACLFNGLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7H2</accession>
    <name>A0A401Q7H2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018828">
        <property type="protein sequence ID" value="GCB81320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7H2"/>
    <dbReference type="STRING" id="75743.A0A401Q7H2"/>
    <dbReference type="OMA" id="EAMHICK"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25788" checksum="99A753945FBC11F8" modified="2019-05-08" version="1">MTVAEQLRRQFVTLKEKIQVSKASIANTSKDKPFEAVGRRALKKPESLERMSIEVVDFGSFGIEDQKVAEAMHICKKFFTLPSDIKQQYARSVVDTENLDHGWVGAEIESLNPTRPGDLKETFNVSTLSSRIVMHKSGQFVAALHSPNAVLLNIGDLLQRWTSDRLISTVHRVLLPQSDDKMCKSRQSLAFFVHPDDNVIVTCCDGSEKYPPTNTLQYLMGRINATYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q913</accession>
    <name>A0A401Q913_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026988">
        <property type="protein sequence ID" value="GCB81856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q913"/>
    <dbReference type="STRING" id="75743.A0A401Q913"/>
    <dbReference type="OMA" id="YEAQMMS"/>
    <dbReference type="OrthoDB" id="8962476at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010832">
        <property type="entry name" value="ProSAAS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07259">
        <property type="entry name" value="ProSAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="290" mass="31901" checksum="D40A65A144BA013B" modified="2019-05-08" version="1">MFAYPPGEAARNEAFYAPLASRAVLARLGLGPREQELLERQGLVLGQADMTPSLGGQGGDERLGEALQRLLEESWRRDQEAAYLANLLRAWSEMGLLEAYPGDVKETEPEPRNGYPDYDELAAGRYGNRQMAYDPPGRPGLDQTAGDAGGELEQQVMRYMVGRILANLDTDAGYAPRPPRLVKRDLPEAPGPRRVRRALVEEEAGGAGGRTNLLRVKRLGQEEKAEEDGGAQDGARYPPPGAKEAWAPPGLQRIKRIEERLPGPGAVRNRRYAGYQGAELAERFIKFLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9V4</accession>
    <name>A0A401Q9V4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH oxidase activator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0021542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019313">
        <property type="protein sequence ID" value="GCB82163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9V4"/>
    <dbReference type="STRING" id="75743.A0A401Q9V4"/>
    <dbReference type="OMA" id="CACEVLY"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF3">
        <property type="entry name" value="NEUTROPHIL CYTOSOL FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB82163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23489" checksum="9505FC7A3A08B086" modified="2019-05-08" version="1" fragment="single">MSLTDTIRQWDEGISAADRQEWVTALDWFTGILEPTSKICYNIGCLRLLLEELNQAEKAFDKSICRDEHLAVAFFQRGITLYKNEKYDEALRDFIEAFNRMRGNQLIDYNQLGLRYKLCTCQVLHNVALAYATIKKWNEAEEALKKALTFKTEAKSNFVDQALEAVLKQELFQLLQLPTELFRPKRKIVAQLEKQDFLGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAW2</accession>
    <name>A0A401QAW2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019468">
        <property type="protein sequence ID" value="GCB82447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAW2"/>
    <dbReference type="STRING" id="75743.A0A401QAW2"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="100" mass="11001" checksum="B5C90F085360A634" modified="2019-05-08" version="1" fragment="single">KKHTLRARILREVQEIIPRVPAGKLIVQSFVFAVCKQIFAMDSLTAANTRFVTDLFKKISEGRSNESIFLSPLSISAALAMVYLGAKNNTADEMAEVSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC69</accession>
    <name>A0A401QC69_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01037811">
        <property type="protein sequence ID" value="GCB82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC69"/>
    <dbReference type="OMA" id="FRIYPTI"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033280">
        <property type="entry name" value="Membrane_MLC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17597">
        <property type="entry name" value="MEMBRANE PROTEIN MLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17597:SF0">
        <property type="entry name" value="MEMBRANE PROTEIN MLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019194921" evidence="1">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="9324" checksum="E2B1D15F3685D9BE" modified="2019-05-08" version="1" fragment="single">QSYDILVFVLMLLLLVQSSLSLATVIHCMSYKLQIKYYDSTWNMSDFQKENCKTIEIPKAPAKDFDKDKAWKAVMVQMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC83</accession>
    <name>A0A401QC83_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034032">
        <property type="protein sequence ID" value="GCB82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC83"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8722" checksum="C913A82FF168A8BE" modified="2019-05-08" version="1">MFLQTESCSCGSFLDTDQGERFVSVFTHIRLQYVINDLVSAKIIEQDTVIPSGWLAAVYKQQWFSMLRTEQDNDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD94</accession>
    <name>A0A401QD94_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0023993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01037244">
        <property type="protein sequence ID" value="GCB83297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD94"/>
    <dbReference type="STRING" id="75743.A0A401QD94"/>
    <dbReference type="OMA" id="KCIGIPS"/>
    <dbReference type="OrthoDB" id="10016075at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000006">
        <property type="entry name" value="Fatty acid-binding protein, liver"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="5">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB83297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="136" mass="15162" checksum="1CB4936BBC25C606" modified="2019-05-08" version="1" fragment="single">VPDPSSIIMAFSGKYEVASQENYDEFMKVLKYPADTIEKGRNAKVITEVTQNGNNFTWSQVYPGGKTMKNTFVIGQESEMETMDGKKFKATVKMEGNKIVCDFPNYHHTSEIDGANLVETSTCSGVAYKRISKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEX5</accession>
    <name>A0A401QEX5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01051266">
        <property type="protein sequence ID" value="GCB83926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEX5"/>
    <dbReference type="STRING" id="75743.A0A401QEX5"/>
    <dbReference type="OrthoDB" id="8963379at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="348" mass="40645" checksum="B2F57D8D968B8850" modified="2019-05-08" version="1">MVDNIQHMLPDKEWFWNSLVQFGIVRHSPLKSGGVWDSLAGSETVWHSLEQSGTTGTVWDSLEQSGTTGTVWDSLKQSGTTGTVWHSLEQSGTVWHSLEQSGTVWHSLEQSGTVWNSLAWSGTVWNSLKQPGTTGTVWHGLEQFGTVWNSLAQSGTVWHGLEQSGTIVPEYYYTVQQTVPQYYYTVLQTVPECYYTVLQTIPQYYYTVLQTVPEYYYTVLQSVPEYYYTVLQTVPEYYYTVPQTVPEFYYTVLQTVTEYYYTVLQTVPQYYYTVLQTVPEHYYTVLQTVPEYYYTQLQTVPEYYYTVIQSVPEYYYTVVQTVPEYYYTVLQPVPEYYYTVLQTVPEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEZ0</accession>
    <name>A0A401QEZ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01055360">
        <property type="protein sequence ID" value="GCB83988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEZ0"/>
    <dbReference type="STRING" id="75743.A0A401QEZ0"/>
    <dbReference type="OMA" id="QENMRES"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="54315" checksum="8E58F72DC7D1CED2" modified="2019-05-08" version="1" fragment="single">RDRERETERERDGERERPRVRDRERDRERDREREREREKERDKRERDRERERQERERQRERERETEIERERQRERDRERKRRRERDGERERQRERDRERDRERERQRERDTETERERDRARETARERQRGRDSKGETERERETETERERGRERDRDRATERETEGERQTERDRETRRERQREMERERWRQSDRERQSERERETERDRERERQRERERERQERERQRERERETRERETERKRERDRERERQRQSDRERETERQRERQRERRRERDRQRERDRERETERHGERERDRDRERWRERDGDRATERETERESERETERERERDRERESERQRERDKRERDRERERERETEREKERDKRERDRERDRERDRERGKQTEYRMRDASFEKINSSFSPLRTRDPVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF19</accession>
    <name>A0A401QF19_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0024519</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01048763">
        <property type="protein sequence ID" value="GCB83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF19"/>
    <dbReference type="STRING" id="75743.A0A401QF19"/>
    <dbReference type="OMA" id="IHTSIRI"/>
    <dbReference type="OrthoDB" id="5956310at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002231">
        <property type="entry name" value="5HT_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF196">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01101">
        <property type="entry name" value="5HTRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="38"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="364" mass="41070" checksum="38BD50CEB98E03FF" modified="2019-05-08" version="1">MNFTNCSYESCAGQTKTFTERCVIALVLSLITILATLLNTAVIAAICITKKLHQPANYLICSLALTDLLVAILLMPVSIMYITTETWFLGYIVCEAWLSLDMTLCTCSILHLCVIALDRYWAITDAVEYTRKRTAKRAGVMILAVWAISVFISVPPLFWRSHNVNSTGEKCIIQHDHVIYTIYSTFGAFYVPLALILILYYRIYHAAKNLYQKRGSSRHFSGRNSDSQISTYMSYKLTHTFCVSDLPSSEPALKFQNDHVTVRIPALDNGVGSTCERQQISSSRERKAARILGLILGAFIICWLPFFIKELLVGLHLWAASALVADCLTWLGYVNSVINPLLYTSFNEDFKLAFRKLTRCRKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGC8</accession>
    <name>A0A401QGC8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01069910">
        <property type="protein sequence ID" value="GCB84416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGC8"/>
    <dbReference type="STRING" id="75743.A0A401QGC8"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="55" mass="6205" checksum="4F14737AF5C06DE5" modified="2019-05-08" version="1" fragment="single">MPYGSLYNVLHEGTNFVVDQTQAVKFALDIARGLAFLHTLEPLIARHYLNSKSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGN3</accession>
    <name>A0A401QGN3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PheRS DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01075815">
        <property type="protein sequence ID" value="GCB84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGN3"/>
    <dbReference type="STRING" id="75743.A0A401QGN3"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PheRS DNA binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="47" mass="4901" checksum="5AC3BA9005CB9E0E" modified="2019-05-08" version="1" fragment="single">MAAERELLLRLQEADGGGLDSGQLAARLGLDHQLLVGAVKSLQTLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGX5</accession>
    <name>A0A401QGX5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01069510">
        <property type="protein sequence ID" value="GCB84567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGX5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="65" mass="6476" checksum="79C8503E0331AA24" modified="2019-05-08" version="1" fragment="single">MSGEGVNGEGVSDEGVNDEGVSDEGVSDEGVSGEGVSDEGVSDEEVSVEGVSDEGVSDEAVIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ35</accession>
    <name>A0A401QJ35_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0026082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01156490">
        <property type="protein sequence ID" value="GCB85369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ35"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019354483" description="ABC transmembrane type-1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB85369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="55301" checksum="4060AA49D4FF6630" modified="2019-05-08" version="1" fragment="single">LLDLFLGLLLDLFLDLLLHLFLDLLLDLFLDLLLDQFLDLLLDLLQDLLPDLLLDLLLDLFMDLFMDLFMDLLLDLFLDLLLDLFLDLFLRLFLDLFLDLLLDLLLDLFLDLFLYLLLDLFLDLLLDLFLDLFLRLYLDLFLDLHLDLFLDLFLDLLLDLFLDLFLHLFLDLFMDLILDLLLDLFLDLFLDMLLDLFLDLFLDLFMDLFLDLFLDLLLEQLLDLFLDLFLDLLLDLLLDLFLDLLLDLFLDLLLDLSLGLFLDQFLDLLLDLFLGLFLDLFLDLLLDLFVDLLLDLLLDLLLDLLLGLFLVLFLDLFLDIFLDLLLDLFQDLLWDHFLDLFLDLPLDLLLDMFLDLFQDLLLDLLLDLFLDLFLDLLLDLLLNLLLDLFLYLIMDLLLGLLLDLFLYLFLDLLLDLLLGLLLDLLLDLLLDLFLICSWISSWICSWISSWICSWICSWIYTWICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLI4</accession>
    <name>A0A401QLI4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01255163">
        <property type="protein sequence ID" value="GCB86173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLI4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="8305" checksum="0211230F54F32C38" modified="2019-05-08" version="1" fragment="single">RNEMKEGERELNETKESERERNEMKEYEEERNETKVGERERSEMKEGQRERKKSKEGQRERNETKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLZ7</accession>
    <name>A0A401QLZ7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01279089">
        <property type="protein sequence ID" value="GCB86406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLZ7"/>
    <dbReference type="STRING" id="75743.A0A401QLZ7"/>
    <dbReference type="OrthoDB" id="3926016at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="305" mass="32650" checksum="A702811C77FC6AB4" modified="2019-05-08" version="1" fragment="single">DDTGHRFITDSDDTGHRFITDSDDTGHGIITDSDDTGRGFITDSDDTGHGFITDSNDTGHRFITDSDDTGHGFITDSDDTGRGFITDSDDTGHRFITDSDDTGHGFITNSDYTGHRFIIDSDDTGHRFITNRDDTGHRFITDSDDTGHGFITDHDDTGHGFITDSDDTGHGLITDSDVTGHGLITDSDDTGHGFITDSDDTGHGLITGSDDTGHGLITDSDDTGHWFITNSDDTGHGLITDSDDTGQRFITDSDDTGHGFITNSDDTGHRFITNSDDTGHGLITDSDDTGHGLITDSDDTGHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGK4</accession>
    <name>A0A401NGK4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0009103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CREC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003628">
        <property type="protein sequence ID" value="GCB60053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGK4"/>
    <dbReference type="STRING" id="75743.A0A401NGK4"/>
    <dbReference type="OMA" id="TELKRWI"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16229">
        <property type="entry name" value="EFh_CREC_RCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000109">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000110">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000213">
        <property type="entry name" value="Reticulocalbin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027241">
        <property type="entry name" value="Rcn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF17">
        <property type="entry name" value="RETICULOCALBIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="364" mass="43428" checksum="FAD138B86EDE6702" modified="2019-05-08" version="1">MLSSSRYAEYGIPYTRCAISRRSLFSIPRGRGCFKQVPLVTNCNMGSPRLFHFLLLYIAGVCPKPTLRHERVHQEPELSDQVHADSENFQYDHEAFLGREEAKTFDQLTPEESVERLRKIVERIDDNQDQYVTTEELKAWIIRVQKRYIYENVAKVWRDYDLNKDNKISWEEYKKATYGYYLENPEEFQDAADQLSFKKMLPRDERRFQAADLDGDMVATREEFTAFLHPEEFEHMKEIVVYETLEDIDKNEDGFVDEDEYIADMYEREEGISEPEWVKTEREQFTDFRDLNKDGKMDKSEIKHWILPEDYDHAQAEARHLVYESDKNRDKRLSKQEILDNWNMFVGSQATNYGEDLTRNHIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHE0</accession>
    <name>A0A401NHE0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001109">
        <property type="protein sequence ID" value="GCB60286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHE0"/>
    <dbReference type="STRING" id="75743.A0A401NHE0"/>
    <dbReference type="OMA" id="INNCILD"/>
    <dbReference type="OrthoDB" id="10057631at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097731">
        <property type="term" value="C:9+0 non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120160">
        <property type="term" value="F:intraciliary transport particle A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040028">
        <property type="entry name" value="IFTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35543:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35543">
        <property type="entry name" value="PROTEIN C11ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17722">
        <property type="entry name" value="IFTAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33843" checksum="153F4C5C92B729CA" modified="2019-05-08" version="1">MPLEVQEENSCAAGSLWPTFLTKKEDFPVKIEQRESGVDESSVCGACRFQSRPPRLQLPENATPALPRPLGVAKRQEGRLNISAFEMPAVFGSQPMEEGLIAFDVLDRFCSSHEQTYAEFLKSFMHLKKEDLKKQKALPPEYGTKTKVDECKLVQREWSENSGQKGGKPSKDDQEANNYLDIGEMDSEIVTANFSNAGCEILPGEIKEENATDYSCFEYKHTSLNFKMNLKVEEFNNKTLDQVLTDEVQPFTLDEDFDYDCVCLKPKYTEAELKTISALSKQKTDSGEFNAEKLKDIAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI38</accession>
    <name>A0A401NI38_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0003958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001127">
        <property type="protein sequence ID" value="GCB60540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI38"/>
    <dbReference type="STRING" id="75743.A0A401NI38"/>
    <dbReference type="OMA" id="TRWGDMA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB60540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="373" mass="40562" checksum="2DA16226F657B21E" modified="2019-05-08" version="1">MSAELFRRLVDNSDEVSEVEHDAARSIKQGKWTDLHQAAYSSNGGLVKTLLQHGAPIDTRDEYGWTPLHHAAFNGYLALVKLLVHRGAPIDAADQHGWTALHRATWNGHTQVAEFLLRRGALTTACTRCGMTPLHCAAACGHTLTMQQILTYGASTDVSDARCWTPLHWAVVSGQPHIIEFLLSKGASVNCMTCGNMTPLHLAVEVGNGEVIQLLLENGAWINAEDDMGRTALSIAAANGHQEIVTDLLAREAADSNRDSALQAAARIGHIRLLELLSERGTSVDIRDSLNMTALHRAAERGDTAIAEFLLEHGADIEARGRLKKTPLHLAMEKGHERFIHLLLSKGANVFATSQWAETPLDVASAQAFQKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIS3</accession>
    <name>A0A401NIS3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-iminobutanoate/2-iminopropanoate deaminase</fullName>
            <ecNumber evidence="8">3.5.99.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Translation inhibitor L-PSP ribonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0006925</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:39975"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:76545"/>
            <dbReference type="EC" id="3.5.99.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2-iminopropanoate + H2O = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:40671"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:44400"/>
            <dbReference type="EC" id="3.5.99.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotrimer. Interacts with YTHDF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.10" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01002423">
        <property type="protein sequence ID" value="GCB60763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIS3"/>
    <dbReference type="STRING" id="75743.A0A401NIS3"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120241">
        <property type="term" value="F:2-iminobutanoate/2-iminopropanoate deaminase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000008">
        <property type="entry name" value="ribonuclease UK114 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB60763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="141" mass="15015" checksum="B4C4DD16B3555743" modified="2019-05-08" version="1">MAALVRRIVSTTKAPGAIGPYSQAVVVDRTMYISGQLGLDPATGQLVTGGTTQEAKQALINMGEILKVANCNYNNVVKTTVLLADINDFNCVNDVYKKYFTTNFPARAAYQVAALPRGGRVEIEAVAVLGPIVEGALEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKA8</accession>
    <name>A0A401NKA8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006375">
        <property type="protein sequence ID" value="GCB61300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKA8"/>
    <dbReference type="OMA" id="ETIEWET"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23665" checksum="14E2FC85FFFADABF" modified="2019-05-08" version="1" fragment="single">IVAAIFAMAGIVMITYSDGFHSHSVIGITLVVASASLSALYKVLFKMLLGSAKYGEAALFLSALGVFNVTFITCVPLALYFTGVEHWTPFSLIPWEKLCGMAILLLSFNILMNFGIAVTSPTLISVGVVLSVPVNAVAEAYSSDIVFNSVRVVAILIICLGFLLLLLPEEWDRLAVEFISRFKVSKKEEAVEERGEPGFTGQSRNKGSRTSTATFAHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKC4</accession>
    <name>A0A401NKC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Disabled homolog 2-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001177">
        <property type="protein sequence ID" value="GCB61361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKC4"/>
    <dbReference type="STRING" id="75743.A0A401NKC4"/>
    <dbReference type="OrthoDB" id="5572587at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021887">
        <property type="entry name" value="DAB2P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF26">
        <property type="entry name" value="DISABLED HOMOLOG 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12004">
        <property type="entry name" value="DAB2P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disabled homolog 2-interacting protein C-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="186" mass="21512" checksum="22BA9936902404ED" modified="2019-05-08" version="1">MAYLFPMYDSPLMGSKHVGNFDPVVAKTGLPPGLWIKHLLLWWWAVLDSSEPEIHEKQHCLDNQEDQAQKMMLEYQARKEGEERLRRQKEDKDVQMKGIISRLMAVEDELKKDHSEMQAAVDSKQKIIEAQEKRIVSLDAANARLMRALSQLKERYSMLSRNGISPTNPTKLQITEDGEFRNNSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKJ8</accession>
    <name>A0A401NKJ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein transport protein Sec24C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0014323</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007640">
        <property type="protein sequence ID" value="GCB61369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKJ8"/>
    <dbReference type="STRING" id="75743.A0A401NKJ8"/>
    <dbReference type="OMA" id="NSMMPGP"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000020">
        <property type="entry name" value="protein transport protein Sec24D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000003">
        <property type="entry name" value="SEC24 homolog D, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF5">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC24C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="10">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="11">
        <location>
            <begin position="515"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="13">
        <location>
            <begin position="764"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="12">
        <location>
            <begin position="860"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB61369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122361" checksum="3CC483A6EFBD4EF8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLM5</accession>
    <name>A0A401NLM5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spermatogenesis-associated protein 24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002515">
        <property type="protein sequence ID" value="GCB61760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLM5"/>
    <dbReference type="STRING" id="75743.A0A401NLM5"/>
    <dbReference type="OMA" id="HITKQED"/>
    <dbReference type="OrthoDB" id="10047985at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029176">
        <property type="entry name" value="SPATA24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35155">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35155:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15175">
        <property type="entry name" value="SPATA24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="24138" checksum="4A963DA3FAE3B9E0" modified="2019-05-08" version="1">MADWRTHSLVHQQLQDVVLTQQQQIRRFGQTIKQREVESVSREEFDVVVKELENERLEHAKTKALLFKESEKLQFSLGEIEILMKQLDREKKAFENALGSIKNKALKESTKNDKLISKCNEIENQMEKQDDILSRKEGQIEELYQLLAKQKDTLKHQVADFEIQKQQDAYIARVLKEKKRKSTQTRGERANSMQSPETGIELGSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLT9</accession>
    <name>A0A401NLT9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">scyTo_0009407</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01003836">
        <property type="protein sequence ID" value="GCB61832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NLT9"/>
    <dbReference type="OMA" id="HELHIER"/>
    <dbReference type="OrthoDB" id="10047816at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20865">
        <property type="entry name" value="C1_MRCKbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000140">
        <property type="entry name" value="CDC42 binding protein kinase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001209">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031597">
        <property type="entry name" value="KELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014930">
        <property type="entry name" value="Myotonic_dystrophy_kinase_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF34">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MRCK BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08826">
        <property type="entry name" value="DMPK_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15796">
        <property type="entry name" value="KELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="54"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="28">
        <location>
            <begin position="321"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="25">
        <location>
            <begin position="1007"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="23">
        <location>
            <begin position="1077"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="27">
        <location>
            <begin position="1222"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="26">
        <location>
            <begin position="1566"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="954"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1596"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="418"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="658"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="882"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1609"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1656"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="GCB61832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1691" mass="192966" checksum="3808482CC0547A90" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMH6</accession>
    <name>A0A401NMH6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003860">
        <property type="protein sequence ID" value="GCB62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMH6"/>
    <dbReference type="STRING" id="75743.A0A401NMH6"/>
    <dbReference type="OMA" id="FHAIIWH"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="88" mass="9993" checksum="9DB3BF7690BC22AC" modified="2019-05-08" version="1">MCLCSRSVSKPSQFKSSASKKVSIAGWMVVLPDDPEHPDIFQLSDPDKGNVYKFQTSSRFHAILWHKHLDDACKSNRPQIPTNLMSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMT9</accession>
    <name>A0A401NMT9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRMT5</name>
        <name evidence="11" type="synonym">TRM5</name>
        <name evidence="15" type="ORF">scyTo_0004211</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01001231">
        <property type="protein sequence ID" value="GCB62169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMT9"/>
    <dbReference type="STRING" id="75743.A0A401NMT9"/>
    <dbReference type="OMA" id="VGSHSQF"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000102">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019237408" description="tRNA (guanine(37)-N1)-methyltransferase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="14">
        <location>
            <begin position="208"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB62169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="513" mass="58365" checksum="5FB7265DC5E291AA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNF2</accession>
    <name>A0A401NNF2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAR14-like first RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007794">
        <property type="protein sequence ID" value="GCB62421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNF2"/>
    <dbReference type="STRING" id="75743.A0A401NNF2"/>
    <dbReference type="OrthoDB" id="9948435at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057051">
        <property type="entry name" value="PARP14_RPM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23222">
        <property type="entry name" value="RRM_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAR14-like first RRM" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="17561" checksum="536F433A43DE8A8D" modified="2019-05-08" version="1" fragment="single">MRRCEPSHFAPARRHRLQEAEMMSQIPKKIQVLNVPKAIPVPRMLNKLTIYFQKPSNGGGEVLDVEYPTRVNNCAYIIFKKEEDANNVLKQEHVLQIEKKTYKLEVREVEKGFRNADSEQVIQFVTTTLDTSHYPKEKALQLIFRHDLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNL1</accession>
    <name>A0A401NNL1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 23 member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0007236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002579">
        <property type="protein sequence ID" value="GCB62446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNL1"/>
    <dbReference type="STRING" id="75743.A0A401NNL1"/>
    <dbReference type="OMA" id="VPYMGGS"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67791" checksum="B5080F54FEED3AA7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNZ5</accession>
    <name>A0A401NNZ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0007255</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002589">
        <property type="protein sequence ID" value="GCB62579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNZ5"/>
    <dbReference type="SMR" id="A0A401NNZ5"/>
    <dbReference type="STRING" id="75743.A0A401NNZ5"/>
    <dbReference type="OMA" id="ANGYDAC"/>
    <dbReference type="OrthoDB" id="9306077at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000110">
        <property type="entry name" value="Death-associated kinase 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.460:FF:000003">
        <property type="entry name" value="Death-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000250">
        <property type="entry name" value="Death-associated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF17">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB62579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="633" mass="70673" checksum="6009C64A971BEE26" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP19</accession>
    <name>A0A401NP19_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-type tyrosine-protein phosphatase epsilon</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0004274</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer. Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and decreased by EGFR. Isoform 2 interacts with GRB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01001256">
        <property type="protein sequence ID" value="GCB62587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP19"/>
    <dbReference type="STRING" id="75743.A0A401NP19"/>
    <dbReference type="OMA" id="FCVHSLQ"/>
    <dbReference type="OrthoDB" id="6144703at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000007">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000022">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF499">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="21">
        <location>
            <begin position="136"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="314"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="21">
        <location>
            <begin position="426"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="600"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB62587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="695" mass="79220" checksum="42D946E9F69A6E17" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ22</accession>
    <name>A0A401NQ22_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0007311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002621">
        <property type="protein sequence ID" value="GCB62939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQ22"/>
    <dbReference type="STRING" id="75743.A0A401NQ22"/>
    <dbReference type="OMA" id="AEMQNML"/>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="226"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="475"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="659"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="735" mass="82605" checksum="6B486C41D9030F53" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRC9</accession>
    <name>A0A401NRC9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain-like 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0013198</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006649">
        <property type="protein sequence ID" value="GCB63392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRC9"/>
    <dbReference type="STRING" id="75743.A0A401NRC9"/>
    <dbReference type="OrthoDB" id="8542990at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000024">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000035">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="138"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="286"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB63392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="488" mass="54311" checksum="99F1F7EBBD34C631" modified="2019-05-08" version="1">MPSDKTIGGGDDSFNTFFSETGAGKHIPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHCSVGKEIVDLVLDRVRKVRECLSLHIGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHIPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHCSVGKEIVDLVLDRVRKVISTAVVEPYNSVLVTHCTLEHSDCAFMVDNEAIYDVCRRNLDIERPTYTNLNRLIAQVLSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATFSPLISAEKAYHEQLSVSELTNSCFEPANQLVKCDPRQGKYMACCMLYRGDVVPKDVNAAIATIKTKRSIAFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRALCMLSNTTAISLAWTRLNLKFDKMYAKRAFVHWYVGEGLEEGEFQDAREDMASLEKDYEEVGVDSSSLDRKGEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT55</accession>
    <name>A0A401NT55_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0009759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004065">
        <property type="protein sequence ID" value="GCB64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT55"/>
    <dbReference type="STRING" id="75743.A0A401NT55"/>
    <dbReference type="OMA" id="IWQFEGW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF282">
        <property type="entry name" value="SYNAPTOTAGMIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="97"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="247" mass="27976" checksum="66D7D00F67B373B8" modified="2019-05-08" version="1" fragment="single">VQPDVEDLDPSLLGDEKKEEEKLGKLQYSLDYDFQNGQLIVGIIQAAELAALDIGGTSDPYVKVFLLPDKKKKFETKIHRKTLNPTFNESFTFKQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVITVLDYDKLGKNEAIGKCFVGCNATGAELRHWSDMLANPRRPIAQWHTLQPEEEVDIALGIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTC5</accession>
    <name>A0A401NTC5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0011711</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005423">
        <property type="protein sequence ID" value="GCB64120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTC5"/>
    <dbReference type="STRING" id="75743.A0A401NTC5"/>
    <dbReference type="OMA" id="RWVHHAN"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB64120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="96" mass="10332" checksum="A7249BC52E04BE83" modified="2019-05-08" version="1">MVRRKGNYAQRVGAGAPVYLAAVLEYLTAEILELAGNAAWDNKKTRIIPRHLQLAVRNNEELNKLLGGVTITQGGVLPNIQAVLLPKKSSAGTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUE4</accession>
    <name>A0A401NUE4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine-hydroxylase NDUFAF5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Putative methyltransferase NDUFAF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0014773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008054">
        <property type="protein sequence ID" value="GCB64464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUE4"/>
    <dbReference type="STRING" id="75743.A0A401NUE4"/>
    <dbReference type="OMA" id="ITRPMDN"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000199">
        <property type="entry name" value="arginine-hydroxylase NDUFAF5, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="11">
        <location>
            <begin position="107"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB64464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="358" mass="39934" checksum="5DB3B090D6D315FA" modified="2019-05-08" version="1">MSGFPCRLRYLAGLHEGRLHLLLPLNRTLGSGPPPIPPCSGSTATLRPCSSRAGSAMNIFDRKMKRRQKNWASSIPGSERYDYLKEEVGSRIVDRVFDIVRTFPVALDIGCGKGHIAEHLNKDTVQKLFQVDIAENVLKHPVETEIPTYRILADEEFLPFKENTFDLVLSSLSLHWVNDLPRAFKLINYSLKPDGVFIGAMMGGETLYELRCSLQLAELEREGGFAPHISPFTAVTDLGNLLEQAGFNMLTVDIDEIVVNYPGIFEVMEDLRGMGESNCAWSRKPLLHRDTMLAAAAIYKEMYGNDDGSVPATFQILYMIGWKPHESQAKPAQRGSATLSIGDLGKMSELITKKNKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUG4</accession>
    <name>A0A401NUG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase MARCH11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0009823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004112">
        <property type="protein sequence ID" value="GCB64531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUG4"/>
    <dbReference type="STRING" id="75743.A0A401NUG4"/>
    <dbReference type="OMA" id="QWQSITV"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046356">
        <property type="entry name" value="MARCHF4/9/11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46053">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46053:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB64531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20410" checksum="5A205C46AACB0247" modified="2019-05-08" version="1">MKKPCQWEPITVTLVEKVQIIAVILGCLFLIASVTWLLWSAFSPAAIWQRRDILFQICYGMYGFMDLVCIGLIVHEGAAIYRVFKRWRAVNLHWTVLNYDKAKDVEINSGNAGSSAIPTFWASLNQFRTQRSVGSTRLMSEGFHCSYTLLHLLTRFRPHDEEYDDNSSAEVVMRVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUS7</accession>
    <name>A0A401NUS7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000057">
        <property type="protein sequence ID" value="GCB64604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUS7"/>
    <dbReference type="OrthoDB" id="9521942at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050831">
        <property type="entry name" value="CEA_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427:SF1">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="332" mass="36939" checksum="973D69EC5FF29A32" modified="2019-05-08" version="1">METSKVKDAGFYHCAALNTVNGKKLKERSDLVEVVVAGHPPKPAIIVEPPANAIGDGQPVHLSCKVPGTPQGVQYWWRKDNVLLQSSSKDGSLQNLTLHSLSENQSVTYECGITNNVRGRLFETWSDEVKLALAGHSSLDLQALIGSTSGIGISLFILLLAGLLILFFKVQRSKKTNSRSKTSNLSRNNSKNQHKIPRNNADQKGPKSDNKSAQLYIKKAEDLKKAAVLRERMETASWNHQYNALRMNDSQKYTSNLAQRYIVPKPKPCVKEIDNASLDSTYAVPASLRLNIPSTPVETDPDEIYDDRGHPQSPLLHLVLIIIQHYFFDIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUZ1</accession>
    <name>A0A401NUZ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0011783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005483">
        <property type="protein sequence ID" value="GCB64679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUZ1"/>
    <dbReference type="STRING" id="75743.A0A401NUZ1"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF15">
        <property type="entry name" value="DYSTROPHIA MYOTONICA WD REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="647"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB64679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="826" mass="91596" checksum="E3C26D79B511D414" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVC3</accession>
    <name>A0A401NVC3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHX15</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAH box protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0011805</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Identified in the Intron Large spliceosome complex (IL, also named intron lariat spliceosome), a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. The IL complex exists in two distinct conformations, one with the DHX15 (ILS2) and one without (ILS1). Interacts with TFIP11 (via G-patch domain); indicative for a recruitment to the IL complex. Interacts with SSB/La. Interacts with GPATCH2 (via G-patch domain); promoting the RNA helicase activity. Interacts with NKRF (via G-patch domain); promoting the RNA helicase activity. Interacts with NLRP6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01005498">
        <property type="protein sequence ID" value="GCB64825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVC3"/>
    <dbReference type="STRING" id="75743.A0A401NVC3"/>
    <dbReference type="OMA" id="FYTREPE"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF95">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="91"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="282"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB64825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="739" mass="84706" checksum="F07D54D0F5C0070C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVE6</accession>
    <name>A0A401NVE6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA methyltransferase 10 homolog C</fullName>
            <ecNumber evidence="2">2.1.1.218</ecNumber>
            <ecNumber evidence="3">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mitochondrial ribonuclease P protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">RNA (guanine-9-)-methyltransferase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">mRNA methyladenosine-N(1)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA (adenine(9)-N(1))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0013388</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>adenosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43148"/>
            <dbReference type="Rhea" id="RHEA-COMP:10363"/>
            <dbReference type="Rhea" id="RHEA-COMP:10364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.218"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55392"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.218" evidence="2"/>
    <dbReference type="EC" id="2.1.1.221" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01006814">
        <property type="protein sequence ID" value="GCB64827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVE6"/>
    <dbReference type="STRING" id="75743.A0A401NVE6"/>
    <dbReference type="OMA" id="TATDRQH"/>
    <dbReference type="OrthoDB" id="9976048at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160106">
        <property type="term" value="F:tRNA (adenine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18102">
        <property type="entry name" value="Trm10_MRRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000003">
        <property type="entry name" value="tRNA methyltransferase 10C, mitochondrial RNase P subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025812">
        <property type="entry name" value="Trm10_C_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="21">
        <location>
            <begin position="188"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="395"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB64827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="439" mass="51704" checksum="BB19842A4B6A8B9E" modified="2019-05-08" version="1">MWLRVTHLLQSTGRQYIRQLKTRVKNKVPLTSCQLMPHHRRLVLTPCVKNEEKKVNPEQLDLDIWKTIMRKNAAEAPKPVPSEDLEDSFLAATREMVQMWRLAGKTVPEDITEEQLSTVQELPSKSAKKKYLKYLAIKEGKKKATKEKQKLKQEGAKDLQKEKENEEGIALKNTYLLQFWQRSFDSLYNWRTVQSMMFGQPLVFDMSYESYMARREMENTVSQLLECEGYNRRSLDPFHLHFCNLNPEGSYQKELLKRYGDAWNRLLITITEKSYVDIFPKDKLVYLTADSPYVLKTFQHDKIYIIGSIVDKSIQTGLSHANAKRLKLATARLPLDEYLRWDSGAKNLTLNQMISILLTVKETGSWLEALKFVPKRKHEGFFPLPVEQRYYSRTRNDQNKKTIINKPETKARWQKSSLRLNQPSRSSDSHKKRWWMEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVK3</accession>
    <name>A0A401NVK3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho-related GTP-binding protein RhoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0013396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006819">
        <property type="protein sequence ID" value="GCB64887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVK3"/>
    <dbReference type="STRING" id="75743.A0A401NVK3"/>
    <dbReference type="OMA" id="THVALIC"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB64887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22062" checksum="00F4CEF88C3F53CB" modified="2019-05-08" version="1">MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRNDENVRNELARMKQEPVRTEDGRAMAVRIGAYDYLECSAKTKEGVREVFETATRAALQKRARPSRGCTNCCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW26</accession>
    <name>A0A401NW26_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secernin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000069">
        <property type="protein sequence ID" value="GCB65081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW26"/>
    <dbReference type="STRING" id="75743.A0A401NW26"/>
    <dbReference type="OMA" id="YETWHTH"/>
    <dbReference type="OrthoDB" id="5175656at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000001">
        <property type="entry name" value="Secernin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF7">
        <property type="entry name" value="SECERNIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47283" checksum="E9EAA0BEC4B963B4" modified="2019-05-08" version="1">MAASTLCAPSSCDCFVALPPSTERKEVIFGKNSDRPRDEVQEVVYFPVTVHAPGSMVECTYIEIEQIQKTHAVILSRPAWLWGAEMGANNHGVCIGNEAVWTKEPIGESEALLGMDLVRLGLERGSTAKEALDVIASLLEQHGQGGNCKESPEAFSYDNTFLIVDKKEAWVLETSGKYWAAQQITEGAKNISNQLTITTEISVEHPGLRDYAQSQGWWSGDGEFNFSQIFSPTNPPVRMEAAKVRYCGGKELLRKQEAGSIQAGTIMDILRDKESGICMDSGAFCTTGSMVSILPQDDGLPCVHFFTATPDPSRSVFKPFIFIDDVMPVSMVISPSYGEDDPVKKRPRFQSKRDRRHELYKAHEQAKATMESGQEQGAQLHQTMKNLERQGLLAIQDLLTSGENFDPEEMADLFFDCVDTEIKFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWT0</accession>
    <name>A0A401NWT0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit TOM20 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0004764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001430">
        <property type="protein sequence ID" value="GCB65331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWT0"/>
    <dbReference type="STRING" id="75743.A0A401NWT0"/>
    <dbReference type="OMA" id="DMIAYDG"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000001">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022422">
        <property type="entry name" value="MAS20_rcpt_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01989">
        <property type="entry name" value="EUOM20RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB65331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16741" checksum="C37CAB6FFCCF84F9" modified="2019-05-08" version="1">MLCAGKTGAIAAGLCGAIFLGYCIYFDRKRRSDPDFKKRLRERRRKQRFARERAGLSRLPDLKDAEAVQKFFLEEIQLGEELLAQGDYEKGVEHLTNAIAVCRQPQQLLQVLQQTLPPPVFQMLLPKLPTISQRIVTAQTLVEDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX39</accession>
    <name>A0A401NX39_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0007715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002843">
        <property type="protein sequence ID" value="GCB65424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX39"/>
    <dbReference type="STRING" id="75743.A0A401NX39"/>
    <dbReference type="OMA" id="YDYSADY"/>
    <dbReference type="OrthoDB" id="8958408at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47305:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47305">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="4">
        <location>
            <begin position="398"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="BEN" evidence="4">
        <location>
            <begin position="578"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="726" mass="81907" checksum="CA9FA2F373A20711" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXR5</accession>
    <name>A0A401NXR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transmembrane protein 214</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0000446</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM214 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000086">
        <property type="protein sequence ID" value="GCB65656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXR5"/>
    <dbReference type="STRING" id="75743.A0A401NXR5"/>
    <dbReference type="OMA" id="ASNQWEV"/>
    <dbReference type="OrthoDB" id="10022292at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB65656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="73165" checksum="AFDA0085B5BDF1B5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXZ0</accession>
    <name>A0A401NXZ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nuclear receptor coactivator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0004853</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SRC/p160 nuclear receptor coactivator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001457">
        <property type="protein sequence ID" value="GCB65741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NXZ0"/>
    <dbReference type="OMA" id="VKQENMM"/>
    <dbReference type="OrthoDB" id="10035882at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18949">
        <property type="entry name" value="bHLH-PAS_NCoA3_SRC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000008">
        <property type="entry name" value="Nuclear receptor coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000008">
        <property type="entry name" value="Nuclear receptor coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000027">
        <property type="entry name" value="Nuclear receptor coactivator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056193">
        <property type="entry name" value="bHLH_NCOA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010011">
        <property type="entry name" value="NCO_DUF1518"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032565">
        <property type="entry name" value="NCOA2/3_DUF4927"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056194">
        <property type="entry name" value="NCOA3_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009110">
        <property type="entry name" value="Nuc_rcpt_coact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014920">
        <property type="entry name" value="Nuc_rcpt_coact_Ncoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037077">
        <property type="entry name" value="Nuc_rcpt_coact_Ncoa_int_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017426">
        <property type="entry name" value="Nuclear_rcpt_coactivator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014935">
        <property type="entry name" value="SRC/p160_LXXLL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684:SF3">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23172">
        <property type="entry name" value="bHLH_NCOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07469">
        <property type="entry name" value="DUF1518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16279">
        <property type="entry name" value="DUF4927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16665">
        <property type="entry name" value="NCOA_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08815">
        <property type="entry name" value="Nuc_rec_co-act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08832">
        <property type="entry name" value="SRC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038181">
        <property type="entry name" value="Nuclear_receptor_coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01151">
        <property type="entry name" value="DUF1518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69125">
        <property type="entry name" value="Nuclear receptor coactivator interlocking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 14" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BHLH" evidence="17">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="572"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="643"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="649"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR038181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB65741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1440" mass="156431" checksum="1AE15F70992C855F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZF5</accession>
    <name>A0A401NZF5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Parafibromin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cell division cycle protein 73 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0004933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001490">
        <property type="protein sequence ID" value="GCB66243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZF5"/>
    <dbReference type="STRING" id="75743.A0A401NZF5"/>
    <dbReference type="OMA" id="NEWSIVF"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000001">
        <property type="entry name" value="Cell division cycle 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB66243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="158" mass="18737" checksum="7F48B964D0154480" modified="2019-05-08" version="1" fragment="single">PIVFISLLRNSRFFPSDEKKKQGCQRENEILIQRRKDQVQPGGTAISVTVPYRVIDQPLKLLPQDWDRVVAVFVQGAAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEMRLDPNVQKWDVTVLELSHHKRHLDRAVLLRFWETLDRYLVKHKSHLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZN0</accession>
    <name>A0A401NZN0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Retinoid isomerohydrolase</fullName>
            <ecNumber evidence="16">3.1.1.64</ecNumber>
            <ecNumber evidence="15">5.3.3.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Lutein isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Meso-zeaxanthin isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0014978</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31775"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="EC" id="3.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31771"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
            <dbReference type="EC" id="3.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>lutein = (3R,3'S)-zeaxanthin</text>
            <dbReference type="Rhea" id="RHEA:12729"/>
            <dbReference type="ChEBI" id="CHEBI:28838"/>
            <dbReference type="ChEBI" id="CHEBI:138919"/>
            <dbReference type="EC" id="5.3.3.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="21">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.64" evidence="16"/>
    <dbReference type="EC" id="5.3.3.22" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01008275">
        <property type="protein sequence ID" value="GCB66313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZN0"/>
    <dbReference type="STRING" id="75743.A0A401NZN0"/>
    <dbReference type="OMA" id="CASHTDS"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052885">
        <property type="term" value="F:all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050251">
        <property type="term" value="F:retinol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901827">
        <property type="term" value="P:zeaxanthin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF57">
        <property type="entry name" value="RETINOID ISOMEROHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 21" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0844">Vision</keyword>
    <feature type="binding site" evidence="21">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB66313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="241" mass="27502" checksum="303A9503BD2D926A" modified="2019-05-08" version="1" fragment="single">MANQIEHPSGGYRKLFETVKETAQPLPACVTGAIPSWLKGSLLRCGPGLFEIGSEPFYHLFDGQALLHKFDFKNGEVTYYRRFVQTDAYVRAMTEKRIVITEFGTFGYPDPCKNIFSRFFSYFEGLEITDNALVNVYPIGEEYYACTETNYITKIDPETLETIQKVDLCKYCVINGATAHPHIERDGTVYNIGNCFGKRFSFAYNIIKIPPLQSDSQDPMKKTEVVVQFPCSDRFKPSYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZP4</accession>
    <name>A0A401NZP4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0010092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004282">
        <property type="protein sequence ID" value="GCB66358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZP4"/>
    <dbReference type="STRING" id="75743.A0A401NZP4"/>
    <dbReference type="OrthoDB" id="8794179at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB66358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="145" mass="16352" checksum="E9D0944BA86E8BE7" modified="2019-05-08" version="1">MLEVTRKIKRACRQLYIYTVSINCEKIAYSVEINRLLWPVAEGTLDRHITQAQAKESQQQIPLNVVKLWASAFGGEIKSISAKYSGSQFLQKVNDQDSDLKVLVSKYTQDVAVGIQANEQFAKDHPKPVVVWTDVVHTYAKELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P046</accession>
    <name>A0A401P046_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004293">
        <property type="protein sequence ID" value="GCB66498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P046"/>
    <dbReference type="STRING" id="75743.A0A401P046"/>
    <dbReference type="OMA" id="QQTLNAC"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10312" checksum="D452545F5A901AC8" modified="2019-05-08" version="1">MSRPLLGLILLNEKYFGELRSNLISNQGLEQQQTLNACFEKLMEGVEQNLLIKNRDRFTQNMSVFKRDVTEILRISTAANTPVGTVYMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1A4</accession>
    <name>A0A401P1A4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERO1-like protein alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Endoplasmic reticulum oxidoreductase alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Oxidoreductin-1-L-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0007963</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002973">
        <property type="protein sequence ID" value="GCB66909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1A4"/>
    <dbReference type="STRING" id="75743.A0A401P1A4"/>
    <dbReference type="OMA" id="NSSIFDC"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF1">
        <property type="entry name" value="ERO1-LIKE PROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="20">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB66909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="349" mass="40607" checksum="B78CC7122E5C7F13" modified="2019-05-08" version="1" fragment="single">YTEEPNVISQNARECEKAEKLGAVNNSLSEETKQAVLDWSRHDDSTDNFCEVDDEHCPDAEYVDLLLNPERYTGYKGLEAWKIWNSIYEENCFKPNSIRRPFNPLLPGKGGSFHNWLKGLCLEKRSFYRTISGLHSSINIHLSARYLLRDTWYERKWGHNITEFKQRFDAQITKGEGPCRLRNLYFLYLMELRALSKVLPFFERSTFQLYTGDSTLDAKNKKLLLEIVNLAKSFPFPFDERSLFAGEKKEAENLKEEFRLHFKNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKQINSLLVSGPSQGFHLKRQDIVALFNAFGRISTSIQELQNFRELLETVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1H4</accession>
    <name>A0A401P1H4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoside hydrolase family 13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002977">
        <property type="protein sequence ID" value="GCB66953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1H4"/>
    <dbReference type="STRING" id="75743.A0A401P1H4"/>
    <dbReference type="OMA" id="RRESCVM"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 13 N-terminal" evidence="1">
        <location>
            <begin position="383"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="492" mass="58550" checksum="6A0A99D1821D0BB2" modified="2019-05-08" version="1">MELHAETCVMELRRQSCVMELRRESCVMELRRESCVMELRRESCITELRRQSCIMELRRESCVMELRRQSCIMELRRESCFMELRRESCVMELRAETCVMELRRQSCVTELRRESCITELRRQSCIMELRREPCITELRRESCITELRRQSCITELRRESCITELRRESCVTELRRESCVMELRAETCVMELRRQSCVMELCRQSCVMELRRESCVMELRRESCIMELRRESCVMELRRQSCIMELRREFCVMELRRESCVMELRAETCVMELRRQSCVMELRRESCVMELRRESCAMRLRRVSCITELRRESCITELRSESCITELLSESCVMELRSESCVTELRSESCITELRSESCITELRSESCVTELRSESCVTELLNGWDTSSHHYKKLPFGKWELHIPPNVDGSPPIPHGSKLKVVIGSKTGQQLYRISPWARYVVREQNASTYVWVHWDSPQPYMVSNLFFHKLYAYLQLKNVTCEANKLIPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1X2</accession>
    <name>A0A401P1X2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SNTX thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008383">
        <property type="protein sequence ID" value="GCB67135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1X2"/>
    <dbReference type="STRING" id="75743.A0A401P1X2"/>
    <dbReference type="OrthoDB" id="5985551at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052090">
        <property type="entry name" value="Cytolytic_pore-forming_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040581">
        <property type="entry name" value="Thioredoxin_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594">
        <property type="entry name" value="AIG1-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594:SF16">
        <property type="entry name" value="SI:CH211-281L24.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18078">
        <property type="entry name" value="Thioredoxin_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNTX thioredoxin-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="325" mass="35665" checksum="2CD698B988AF40AF" modified="2019-05-08" version="1">MENPPQAQEIKEEKSKPWFNMPSQWKQIRELVRRFTGFANVNKDYKKTKFIVASVPSQACEGATIHLYEDGAEIPGEFHPPSKPAQPVVSEVTHESVTLDLQSPLCNAGEILRFRVDYKTAQQEEWTSEETPGNAANKRESDFQSTQFGEIKNPFHSSKWKEGAALGEEVYRKLKEWISLRWAVSATLLMIASKLDEIKHTSSTTCVVGSSMAVPGTLSVFGALAAIVLTGCFATPLVVAAAAGTTAALSGSATAGIAKLVNNYQSSNQMSEAKKVIESDALGVEEIHQLLDLLHILHKAIKIYLGRDSFQLCYDGCCHDYGAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P283</accession>
    <name>A0A401P283_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007086">
        <property type="protein sequence ID" value="GCB67222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P283"/>
    <dbReference type="STRING" id="75743.A0A401P283"/>
    <dbReference type="OMA" id="SNNQGWP"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06743">
        <property type="entry name" value="PDZ1_L-delphilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF3">
        <property type="entry name" value="DELPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="273" mass="30267" checksum="3F1FD933DEB8F9A2" modified="2019-05-08" version="1">MPSNNQGWPEEFGFRISGNGPCYIISVQEGSSAYVAGLQPGDQILEIEGQDVSSLNCDMLINLARRCKTVPPSIGVVSRIEQIDLLPAADGRFGFNLSGESPLQIEDCLPDSPAAEFGFKSGDYVLEVNGIPVKHYEVAAAMIKANHGKPLKLGVLCFGRRQKRISSSIREYVQNADAIHQERKCKALEFNKKVDAVLGEQPEVKEKLFTLLKQYAAERKVDYLAYALPMILSTEEQQQLIDDIRIFYLLLTWPWIVSESGNTSLVEWAAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4S8</accession>
    <name>A0A401P4S8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008496">
        <property type="protein sequence ID" value="GCB68134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4S8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9629" checksum="829DD43D3A6F5ADA" modified="2019-05-08" version="1">MIHRCLSSRLSEKWRDIFFLPDSNRGPSCLTKKDCTDITEEDKKTFNARERTKNDVKVLPPCEEEAMEILGEQGGQSVADVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P509</accession>
    <name>A0A401P509_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005856">
        <property type="protein sequence ID" value="GCB68176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P509"/>
    <dbReference type="STRING" id="75743.A0A401P509"/>
    <dbReference type="OMA" id="QHGKGIP"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03869">
        <property type="entry name" value="M14_CPX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000007">
        <property type="entry name" value="Carboxypeptidase X (M14 family), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000007">
        <property type="entry name" value="Carboxypeptidase X, M14 family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF45">
        <property type="entry name" value="INACTIVE CARBOXYPEPTIDASE-LIKE PROTEIN X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="8">
        <location>
            <begin position="99"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="537" mass="61935" checksum="12759C0A82843596" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5C5</accession>
    <name>A0A401P5C5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat-containing protein 5A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005866">
        <property type="protein sequence ID" value="GCB68296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5C5"/>
    <dbReference type="STRING" id="75743.A0A401P5C5"/>
    <dbReference type="OMA" id="VECALVM"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000098">
        <property type="entry name" value="HEAT repeat-containing protein 5A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000262">
        <property type="entry name" value="HEAT repeat-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB68296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1129" mass="122769" checksum="764AB5B463315DD3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6L9</accession>
    <name>A0A401P6L9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0005363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001660">
        <property type="protein sequence ID" value="GCB68791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6L9"/>
    <dbReference type="STRING" id="75743.A0A401P6L9"/>
    <dbReference type="OMA" id="CARYDQR"/>
    <dbReference type="OrthoDB" id="10672753at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="228" mass="27601" checksum="320B938BDC593AFB" modified="2019-05-08" version="1" fragment="single">MPSDGFAKQRNYVNRDLARARYDQRDPARARYDQRDLACARYDQRDLACARYDKRDFARARYGRRDLACARYDQRDLACARYDQRDLACARYDQRDLARARYDQCDLARARYDQRDLAHARYDQRDLARARYDQRDLARARYDQRDLARARYDQRDLACARYDQRDLARARYDQRDLARARYDQCDLARARYDQRDLACAHYDQRDLACARYDQRDLACARYDQRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7Z4</accession>
    <name>A0A401P7Z4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0005442</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001691">
        <property type="protein sequence ID" value="GCB69232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7Z4"/>
    <dbReference type="STRING" id="75743.A0A401P7Z4"/>
    <dbReference type="OMA" id="IFRIPMV"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06364">
        <property type="entry name" value="PBP1_CaSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000475">
        <property type="entry name" value="Olfactory receptor C family, g2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000067">
        <property type="entry name" value="Olfactory receptor C family, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF528">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019179241" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="13">
        <location>
            <begin position="27"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="603"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB69232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="866" mass="97350" checksum="9B8C2837884D7284" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8Q8</accession>
    <name>A0A401P8Q8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0012430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006001">
        <property type="protein sequence ID" value="GCB69460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8Q8"/>
    <dbReference type="STRING" id="75743.A0A401P8Q8"/>
    <dbReference type="OMA" id="GSIAWEF"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="98"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB69460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="217" mass="24913" checksum="5023155F522FE3AA" modified="2019-05-08" version="1">MVNPLCDPLVLTTRLLVKCKLLLFWALVYTFCGLTAWLASLKLLWHIIRNPAGTFQRVVRQTSPPCLNDTSLGTHCYVRIKESGLRFHYVAAGERGRPLMLLLHGFPEFWYSWRYQLQEFKSDFRVVAVDLRGYGESDAPIGRENYQLDCLITDVKDIVESLGYKKCVLIGHDWGGLIAWCFAIYYPEMISKIVILNCPHPTIFCGFGAWQILAVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8T9</accession>
    <name>A0A401P8T9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0005492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001713">
        <property type="protein sequence ID" value="GCB69503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8T9"/>
    <dbReference type="STRING" id="75743.A0A401P8T9"/>
    <dbReference type="OMA" id="MAFQYLT"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF27">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="9">
        <location>
            <begin position="89"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="8">
        <location>
            <begin position="280"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="544" mass="61063" checksum="727D490E9A896A9B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB84</accession>
    <name>A0A401PB84_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004703">
        <property type="protein sequence ID" value="GCB70369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB84"/>
    <dbReference type="STRING" id="75743.A0A401PB84"/>
    <dbReference type="OrthoDB" id="7788762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF17">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB70369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="105" mass="11866" checksum="343C45B0A661E5D6" modified="2019-05-08" version="1" fragment="single">MKRKKGPWLTDKPARCPGNGQQNGQLSEGDLLLEALNGFILVVTAEGYVFYTSSTIQDYLGFHQSDVVHQSVFELIHTDDRAMFRHQLHWALNPPACQEVNPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCX3</accession>
    <name>A0A401PCX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0010893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004797">
        <property type="protein sequence ID" value="GCB70966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCX3"/>
    <dbReference type="STRING" id="75743.A0A401PCX3"/>
    <dbReference type="OMA" id="TKCASPE"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000128">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF4">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB70966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="164" mass="19170" checksum="8547828DAEFA3DF5" modified="2019-05-08" version="1">MAVVLNALNSDSHVELSQYRDQHFRGSRYEQDKLLRYSCTLYVGNLSFYTTEEQIYELFSKSGDVKRIIMGLDKIKKTSCGFCFVEYYTRSDAEQCMRFINGTRLDDRIIRTDWDTGFKEGRQFGRGKSGGQVRDEYRTDYDAGRGGFGKLVQMQRVPEPRQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDH1</accession>
    <name>A0A401PDH1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003420">
        <property type="protein sequence ID" value="GCB71166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDH1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="221" mass="24108" checksum="61088855584CAA5C" modified="2019-05-08" version="1">MCETQVTGREAQSQHGTQVTGREAQCQRGTQVTGPEAQYQRGTQVTGPETQYQCGTQGTGREAQCQRGTQVTGREAQCQCGTQVTGREAQYQRGTQVTGPEAQYQRGTQVTGREAQCQRGTQVTGREAQYQRGIQVTGPEAQYQRKTQVTGREAQCQRGTQVTGREAQCQRGTQVTGPEAQYQRGTQVTGPEAQYQDGTQVSGREAQCQRGTQVTGLDAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH79</accession>
    <name>A0A401PH79_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0006307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002103">
        <property type="protein sequence ID" value="GCB72444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH79"/>
    <dbReference type="STRING" id="75743.A0A401PH79"/>
    <dbReference type="OrthoDB" id="6262482at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000153">
        <property type="entry name" value="MUC5B isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058753">
        <property type="entry name" value="TIL_OTOGL_Mucin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF408">
        <property type="entry name" value="MUCIN-5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25962">
        <property type="entry name" value="TIL_OTOGL_Mucin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23244">
        <property type="entry name" value="VWF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="335"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="787"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1216"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1232"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB72444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139375" checksum="905C6B815E2760ED" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH99</accession>
    <name>A0A401PH99_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VWA N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000482">
        <property type="protein sequence ID" value="GCB72502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH99"/>
    <dbReference type="STRING" id="75743.A0A401PH99"/>
    <dbReference type="OMA" id="LENEWMY"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF25">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="VWA N-terminal" evidence="11">
        <location>
            <begin position="113"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB72502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="328" mass="37955" checksum="D73C6B5C5C1DE08B" modified="2019-05-08" version="1">MDKNGLHPVEDKVRTIKEGPTPRNTTELKSFLGLIDYYVTFIPNLTSLLTLLFILLQKYQKWPWEAPQKYKDHEKTVTVQEIDGLQLVKKLAKDMERMFRNKAEAIRRLVEAAENAHLEHEYNSDLEYEYFNAVLINEKDENGNFVELGKEFILEPNEHFNNLPVNISLSDVQIPTNKYNKDPAIVNGVSWSEALNKIFVDNFERDPSLLWQYFGSANGFFRQYPGVKWEPDENGVIAFDCRNRKWYIQAATSPKDVIILVDVSGSMKGLRMTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCINDTLVQADRNNKEVTIMFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIM9</accession>
    <name>A0A401PIM9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="35">Cadherin EGF LAG seven-pass G-type receptor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">scyTo_0006570</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor that may have an important role in cell/cell signaling during nervous system formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002230">
        <property type="protein sequence ID" value="GCB72987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PIM9"/>
    <dbReference type="OMA" id="IVMNGGM"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000021">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000011">
        <property type="entry name" value="cadherin EGF LAG seven-pass G-type receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000059">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000020">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000089">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000286">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000359">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000010">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000023">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000029">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000038">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000040">
        <property type="entry name" value="cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000113">
        <property type="entry name" value="Cadherin, EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000044">
        <property type="entry name" value="Cadherin, EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
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    </dbReference>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="GAIN_B"/>
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    <dbReference type="InterPro" id="IPR046338">
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001879">
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        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
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        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF_laminin"/>
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        <property type="entry name" value="CADHERIN"/>
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        <property type="entry name" value="GPCRSECRETIN"/>
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        <property type="entry name" value="CA"/>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF_Lam"/>
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        <property type="entry name" value="HormR"/>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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        <property type="entry name" value="Growth factor receptor domain"/>
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    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
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            <begin position="2527"/>
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            <begin position="2572"/>
            <end position="2601"/>
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            <begin position="260"/>
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            <end position="581"/>
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            <end position="686"/>
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        <location>
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            <begin position="789"/>
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        <location>
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            <begin position="998"/>
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            <begin position="1122"/>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50268"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
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    <sequence length="3106" mass="346267" checksum="257A3B43ED7292F3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJS4</accession>
    <name>A0A401PJS4_SCYTO</name>
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        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
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        <name evidence="2" type="ORF">scyTo_0006740</name>
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    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002325">
        <property type="protein sequence ID" value="GCB73372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJS4"/>
    <dbReference type="STRING" id="75743.A0A401PJS4"/>
    <dbReference type="OMA" id="CCYKNAD"/>
    <dbReference type="OrthoDB" id="71500at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019117514" description="Rho-GAP domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15866" checksum="15D790B5D97A9F75" modified="2019-05-08" version="1">MLSQAPLFYPAPLALIWVLVDVTVQSGRHPTVLQKLCQLPFQYFSDQRLIKVLFPTLITACYNNPQNKVILEQEMSCILLATFIQDFAQSLNQSDNKPAQQREKAPVAQDYLEFSNRFPRELWENAQKFFLNKETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK44</accession>
    <name>A0A401PK44_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyltransferase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Diphthamide biosynthesis protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein 85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0006795</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with INCA1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01002356">
        <property type="protein sequence ID" value="GCB73492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK44"/>
    <dbReference type="STRING" id="75743.A0A401PK44"/>
    <dbReference type="OMA" id="LDMKWLP"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000910">
        <property type="entry name" value="Diphthamide biosynthesis 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB73492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="468" mass="52724" checksum="77DCC3EC6F912BB6" modified="2019-05-08" version="1">MEARSTARTLQVVDTEYSADAVEWCPIDTWHHVLTCGTYQLKDPKEKGAGDSEINEPHVRQGRLYLYCFNPDRLYSPLTEVQRIEMPAILDLKWCHVPVAGHPVLGIANAEGNLELCHLTHCEKNSCSLEPMCSVSIGPDCLALSLDWSTGREEKPLKIISSDSKGCLSLLSVDGCRSALDVVSRWKAHDFEAWIAAFNYWNTDVVYSGGDDSKLKGWDMRMGTDRAIFISNGHSMGVCSIQSSPHKQHILATGSYDEHVLIWDSRQMKRPLVDTHVRGGVWRVKWHPTQENLLLAACMHNGYHILNCEGTFNSSLEDEKESPILYSYILHNSLAYGADWSRLSFDAQLPTEHQPVSSSTETQSKRKYDQRAKEAQVKFQHLKLQYESPTGLFDMVVEDELDDYGDGFPGSLQASSTSQNMDPAATKQRNPAAVHWTKSKASLLATCSFYDHILHVWRWERSNIVCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKC8</accession>
    <name>A0A401PKC8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0002674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000682">
        <property type="protein sequence ID" value="GCB73594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKC8"/>
    <dbReference type="STRING" id="75743.A0A401PKC8"/>
    <dbReference type="OMA" id="TICCWNI"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070016">
        <property type="term" value="F:armadillo repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000498">
        <property type="entry name" value="Striatin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000058">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF1">
        <property type="entry name" value="STRIATIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB73594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="660" mass="72537" checksum="B6D1B56C5A80F84E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKH5</accession>
    <name>A0A401PKH5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002681</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="BFAA01000685">
        <property type="protein sequence ID" value="GCB73601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKH5"/>
    <dbReference type="STRING" id="75743.A0A401PKH5"/>
    <dbReference type="OMA" id="TIVGDHK"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.930.10:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000216">
        <property type="entry name" value="Tyrosine-protein kinase SYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.930.10">
        <property type="entry name" value="Syk Kinase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023420">
        <property type="entry name" value="Kinase_SYK/ZAP-70_inter-SH2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="83"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="288"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB73601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="551" mass="63200" checksum="27C4BBD4FA579B18" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLI4</accession>
    <name>A0A401PLI4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000793">
        <property type="protein sequence ID" value="GCB73951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLI4"/>
    <dbReference type="STRING" id="75743.A0A401PLI4"/>
    <dbReference type="OrthoDB" id="419138at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019170">
        <property type="entry name" value="Meckelin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274">
        <property type="entry name" value="MECKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09773">
        <property type="entry name" value="Meckelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019331687" description="TNFR-Cys domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52534" checksum="EAB78B4B18246347" modified="2019-05-08" version="1" fragment="single">MVAAGCFSVLLPTLLARLLLAQSTDTSLPFVQPHSCTSSQFYDVSRLECSPCGEALKRGADGLRCVCDVGYAMVDTGSPIAQCSACNKIDQVVSVDKKLCLTCPNCQSCRNDEKIQVVGASPQKILSLPKGCVPCHETFILATNRCTCPPTNLKGGLCFGNTKLPPRAGGLPDSIWYEMHLQASYLACSNVTFSNQTACQLLTNLVVLNVNNLVNGEAYILYSSITPTTNYLPKLFYVDTNIAASLGQTAPDGLSFRKDSQITLKIVKYDARGNFLGWEDVRGGTLQLCPDTQILLDAAYKFGSSYIQTCKLRISDLLSRFPEPVFFELFLLFNDSEGVQKVWPIPVRNLNLDRNDIRAGALRRFFLVDGLTGRRDSLSNPPSSVTYATDVVLRTYLPTRSPTREPPFLLTVQYAQIQDLRAEAQVTFAARYEMSYSVHKRDTDIALGVLGSLAVFIAMLETSSWRRRSGLEFIDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLS3</accession>
    <name>A0A401PLS3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0003165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000844">
        <property type="protein sequence ID" value="GCB74080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLS3"/>
    <dbReference type="STRING" id="75743.A0A401PLS3"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106018">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF35">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB74080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="205" mass="23450" checksum="D49759060E80AC27" modified="2019-05-08" version="1" fragment="single">IQEKTNSLWPHLTKNQVDYKNPLYRKDHSQTQGVLRPHTAPSNFRFWRNMYNRFEKGMHPRQSVTEFLMAVKEETQQLEEELEVLEEKLARLDQSHLRDRREAIKLPHNLESTTDQCLANTPQDYMDNGKPFTSCSSSQADENSETTILIHNMKHSDTDLSGNSDQESGVADLSCRSPSGGDFLSSEDSSKNLSEYPEEIAFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMN7</accession>
    <name>A0A401PMN7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0003476</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000950">
        <property type="protein sequence ID" value="GCB74386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMN7"/>
    <dbReference type="STRING" id="75743.A0A401PMN7"/>
    <dbReference type="OMA" id="EITIHIM"/>
    <dbReference type="OrthoDB" id="8188793at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000008">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000012">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF85">
        <property type="entry name" value="CADHERIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019020193" description="Cadherin domain-containing protein" evidence="13">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="79"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="160"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="269"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB74386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="424" mass="46639" checksum="CC2EF7D575C5D861" modified="2019-05-08" version="1">MRRDFYLHCFLACFSIAHWSHAAPARNSTGTRASTRSRHGLGVKGQVLHRSKRGWVWNQFFVIEEYTGPDPVLVGRLHTDLDSGGGKIRYILSGEGAGTIFVIDEKTGNIHATKTLDREERAEYTLMAQAVDRLTNKPLEPPSEFIVKVQDINDNPPEFLTGPHHAMVPEMSNVGTSVIQVTATDADDPSYGNSARLVYSILEGQPYFSVEPQTGIIRTALPNMDREAREEYLVVIQAKDMGGHMGGLSGTTKVIITLTDVNDNPPKFPQSVYQMSISEAADLGEVVGRVKAKDPDIGENGMVSYRIIDGDGRDLFEIATDSQTQEGVIKLKKQGLDFETKKLYSLKVEGANVYFDPRFVSRGPFKDTATVKISVEDADEPPVFSMPVYIMEVNESAPAGTTVGQVHAMDNDLGRSPIRCVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMV3</accession>
    <name>A0A401PMV3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0003501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000963">
        <property type="protein sequence ID" value="GCB74411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMV3"/>
    <dbReference type="STRING" id="75743.A0A401PMV3"/>
    <dbReference type="OrthoDB" id="8958320at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF1">
        <property type="entry name" value="ELKS_RAB6-INTERACTING_CAST FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB74411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="154" mass="18091" checksum="9793BFA9BEBED3A6" modified="2019-05-08" version="1">MLKVTRESFETTTEARTSTNLSDRIEQLEKVVAQYRDEANIAQAEVDRLLEILKEMENEKSDKDKKIAELEIQMKEQSKKLANLKHKEQVEKKKNAQLLEEARRREDNLADDSHQLQHTGKTYVTVEGFFARNGFIMLRFSENFVIKFREDELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN67</accession>
    <name>A0A401PN67_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM92B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001023">
        <property type="protein sequence ID" value="GCB74577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN67"/>
    <dbReference type="STRING" id="75743.A0A401PN67"/>
    <dbReference type="OMA" id="RPINATN"/>
    <dbReference type="OrthoDB" id="60621at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF3">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06730">
        <property type="entry name" value="FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="36484" checksum="59D39F67F19D0B98" modified="2019-05-08" version="1">MNSSLSRDSQVKIMEGTVNNAEKYLGQFCLLLASYTRKNARLRDKVDLLIKQIMDFANTENPEMRRCLKDFGEEMSKIQDYRQAEVERLDAKVIGPLKEYGRLTKSKRGDIKKFNSVRNREMKELENLQKLKQRNPSDRQGIAEANVQKASVDVNHTTHQLEEIIFKFQQQKLKDIKAIFSNFVTVEMIFHSKALEMYTNAFQHLNNFDEEKDMAAFRSKICISEFENDARPSQSHSSSSLQPSPGSQPGKRLGEARRERKKSNRNKLRTPPRVLHAHFQEDESDDEEEEEDEVEELQDLSDDGYQQYAKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN71</accession>
    <name>A0A401PN71_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001033">
        <property type="protein sequence ID" value="GCB74600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN71"/>
    <dbReference type="OMA" id="RMDESHK"/>
    <dbReference type="OrthoDB" id="5983862at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027867">
        <property type="entry name" value="SPATA48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34759">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34759:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="226" mass="25453" checksum="E882A2BE77E7D198" modified="2019-05-08" version="1" fragment="single">MGQTVIPYVRGPEDRHFFTSFQEQDNAAFARWSPDSSAPDDLYPLAPHRHEVQLLDISSGFKSAGHSAESCTKRIPNLAFYREPGGECRARTAIPIDIQQQSQSSRWNSRSVSSAAIRARVGGWTSPVRVTPPPHSVPDSLKTHNFNFNVDPSVQTSYDATPESARDATARKYMFTTTTQRSYEDVNWDCKLGPKIKSDTIQDKIADPMSRHATLKRYDPSPHMWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNB8</accession>
    <name>A0A401PNB8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tumor necrosis factor receptor superfamily member EDAR death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0003707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001038">
        <property type="protein sequence ID" value="GCB74616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNB8"/>
    <dbReference type="STRING" id="75743.A0A401PNB8"/>
    <dbReference type="OMA" id="CGENEYH"/>
    <dbReference type="OrthoDB" id="9903718at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056762">
        <property type="entry name" value="Death_EDAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047526">
        <property type="entry name" value="TNR19/27/EDAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120:SF9">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER EDAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24979">
        <property type="entry name" value="Death_EDAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019513698" description="Tumor necrosis factor receptor superfamily member EDAR death domain-containing protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tumor necrosis factor receptor superfamily member EDAR death" evidence="12">
        <location>
            <begin position="360"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB74616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="454" mass="49983" checksum="C29C9A571232A3C7" modified="2019-05-08" version="1">MSHRKTLWWTHVFSFVLVSLTSSVIADYSSECEENEYFNQTTGACHACPQCQSGEEPVSNCGYGVKDESYGCQPCQAGKFSKGVYQICRRHKDCEGFFRATVLTPGTAEIDAECGPCIPGYYILDNRSRNTYTKVCHSCALASPNTKECLGITSSSSISSSVSAINANSPILQETHKVDHAGQGHMGTALIIAMSTIFIMAIAIVLIVLFYILKTKSSTQTCCSGQSVKNIEAQINNQEDKKEIQENVVIFSEKDEFDNKLKAVPPKTEKNENDASSENEQLLSRSMDSDEEAALEKRGMSDLCLLSLVPLTRDKSANNKATGIQTRREKILELCKKVCSFTEGLSPTELPFDCLEKTSRMLSSTYSTDKAIVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPDLLTRLVHIERMDAVEALCMDVLECTQAAPIANPAVLPKCPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNU9</accession>
    <name>A0A401PNU9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">ATP-sensitive inward rectifier potassium channel 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0003900</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001105">
        <property type="protein sequence ID" value="GCB74807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNU9"/>
    <dbReference type="STRING" id="75743.A0A401PNU9"/>
    <dbReference type="OMA" id="RMITEHC"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015272">
        <property type="term" value="F:ATP-activated inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000050">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003278">
        <property type="entry name" value="K_chnl_inward-rec_Kir6.1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF11">
        <property type="entry name" value="ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01331">
        <property type="entry name" value="KIR61CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 14" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 14" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="17">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="18">
        <location>
            <begin position="192"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="13">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB74807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47000" checksum="F7CE9FBA6C33E509" modified="2019-05-08" version="1">MLARKSIIPEEYVLARIAAENVRQPRYNVRPRQARFIAKNGSCNAAHKNIREQGRFLRDVFTTLVDLKWRYTLIIFTMSFLCSWLLFAMMWWLLAFAHGDLDQDPDPRRGGPAPAPAPEPCVTKVRSFTSAFLFAIEVQVTIGFGGRMITEECAAAITGLIVQTISGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVVCLRNGKLCFMFRVGDLRKSMIISASVRMQVVKRSSTAEGEVIPLHQIDIAVDNPIESNSIFLVAPLTVSHVLDRRSPLYEMSAGDLQSQNLEVIVILEGVVETTGITTQARTSYISEEILWGYRFVPVVSEEDGTYSVDYSKFGNRVKVATPRCSARELDEKPSILIQTLQKSELSHQNSLRKRSSMRRNNSMRRSTSSLAIPKVQFLTPEASPDVADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPL8</accession>
    <name>A0A401PPL8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017538">
        <property type="protein sequence ID" value="GCB75074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPL8"/>
    <dbReference type="STRING" id="75743.A0A401PPL8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="187" mass="21888" checksum="DC66AFA723926725" modified="2019-05-08" version="1">MDLTPPLQLPYLDLKRPLQLPYLDLTPPLQLPYLDLTPRLQLPYLDLTPPLQLPYLELTLPLQLPYQDLTPPLQLPYLDLTLPLQLRYPDLTLPLQLPYLDLTPPLQLPYLGLTPPFQLPYLDLIHSSSYLTWTSHRHSSYLNWTSHFRSNYLTWTSHRSSSYLTWTSHCHSSYLTQTSNCRSSYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ25</accession>
    <name>A0A401PQ25_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009870">
        <property type="protein sequence ID" value="GCB75219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ25"/>
    <dbReference type="STRING" id="75743.A0A401PQ25"/>
    <dbReference type="OMA" id="IVQTQDF"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF2">
        <property type="entry name" value="EARLY ESTROGEN-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="127" mass="13805" checksum="C547524065B02355" modified="2019-05-08" version="1" fragment="single">PTRRRKLSSSSSGFSSGPSSAADIEGGAKDPPTFEKPPLPIRPSDRSLRRKTRTPESCPSRVSDTRVNADDIVERIVQTQDFTDCSDSEESGLQLFVRPDGSTLVGGIPLSNRRSVSDYKPVVIESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQV7</accession>
    <name>A0A401PQV7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Olfactomedin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013769">
        <property type="protein sequence ID" value="GCB75500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQV7"/>
    <dbReference type="STRING" id="75743.A0A401PQV7"/>
    <dbReference type="OMA" id="PYCYYEC"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF31">
        <property type="entry name" value="OLFACTOMEDIN-4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019410900" description="Olfactomedin-like domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="5">
        <location>
            <begin position="191"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB75500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="460" mass="52803" checksum="4998E4A2FD106EF5" modified="2019-05-08" version="1">MTFAALLLTSSTLLFAEAEYQGVQGVHGVLENGNRCVCKMQFSEWEFPVEKFEQLQDLSNNCTKSLEEQKLEATFAEYKIPEFRAKLQNFTSQLQPFEAMYKQKLYHPLNFWVLRRELKQLRSKIAKVQSVPSSNTDLLRKVSDEMLDAHIIVKDLQQYDKQNLLAMKDYLKKMKNRLESFSVYGKLHIGNCSGGILRNISEPVLAQVNPHGASYYFGGWGMDSMAGSSQLYWVMALMSSSIYGIVIRTYNSYKNFLTAKSHIDISVKASYTVPNAIQGPGVVVHNNSLYYNCYNSGQMCRFDIATKAITNVLLPNAGYNNKFPYCYYVCIGYTDMDFSVDENGLWVIYATEENYGNIVLSKIDSVNLTVLQTWKTKLFKRAVTNAFVVCGVLYATRYISDTKEEIFYMYDTVNNQEAKNLNIQFVKYSSNVANIHYNPVDRKLYLYNGGFMVAYELFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS49</accession>
    <name>A0A401PS49_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0019076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013859">
        <property type="protein sequence ID" value="GCB75945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS49"/>
    <dbReference type="STRING" id="75743.A0A401PS49"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000071">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000089">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838">
        <property type="entry name" value="HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="13">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="456"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="675"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB75945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="752" mass="84947" checksum="00ADC102FDA2EE4E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSP7</accession>
    <name>A0A401PSP7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011322">
        <property type="protein sequence ID" value="GCB76154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSP7"/>
    <dbReference type="STRING" id="75743.A0A401PSP7"/>
    <dbReference type="OMA" id="CPGEDSR"/>
    <dbReference type="OrthoDB" id="10596033at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="20917" checksum="ACB2FF5C96E18102" modified="2019-05-08" version="1">MGPRERVRLLAMGPRERVRLLAMGPRERVPLLAMGPRERVPLLAMGSRERVRLLAMGPRERVRLLAMGPRERVRRLAMGPRERVPQPAMGPRERVRLLAMGPRERVPLLAMGSRERMRRLAMGPRERVRRLAMGPRERVRRLAMGPRERVRRLAMGLGERVRSDSEADAGLSLGIGYWGFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSY6</accession>
    <name>A0A401PSY6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0018316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012638">
        <property type="protein sequence ID" value="GCB76241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSY6"/>
    <dbReference type="STRING" id="75743.A0A401PSY6"/>
    <dbReference type="OMA" id="SDFCFGR"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19411" checksum="5F22662BFC1BE8B7" modified="2019-05-08" version="1" fragment="single">MKTLRLMKVFNLSNAAIFTVVTEFFEKLTYFGVRAILVLYFTNALILSESKATSLYHVFIFLSTSFTIVGAFFSDFCFGRYRTILMLSIVYLAGSIVLSVTAIPTLTGQSGVGAYIGLFFLSLGSGGIRSSMSPFGADQLSRKEEKDYRIYFSFFYFSMNLAALFAGIIIPILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU27</accession>
    <name>A0A401PU27_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012722">
        <property type="protein sequence ID" value="GCB76646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU27"/>
    <dbReference type="STRING" id="75743.A0A401PU27"/>
    <dbReference type="OMA" id="QTESECC"/>
    <dbReference type="OrthoDB" id="432835at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03165">
        <property type="entry name" value="NET-5_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF40">
        <property type="entry name" value="TETRASPANIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB76646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="18530" checksum="15AA02D8144BCA5C" modified="2019-05-08" version="1" fragment="single">MLEVGGCAILGVGIWLAVTQGNFATLSTTIPFISAANLLIGIGIIVMIVGFLGCVGAIKENKCLLLTFFILLLIIFVMEMVGGILFSVYRGQIDIYAREDLKQGLQLFDTDGNIGLTNAWSIIQTDFRCCGVSNYTDWFEAFNTTGAPDSCCREYSVSCGLHSPDTFWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV29</accession>
    <name>A0A401PV29_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014075">
        <property type="protein sequence ID" value="GCB76968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV29"/>
    <dbReference type="OrthoDB" id="10031141at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046642">
        <property type="term" value="P:negative regulation of alpha-beta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002720">
        <property type="term" value="P:positive regulation of cytokine production involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000406">
        <property type="term" value="P:positive regulation of T cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46838">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46838:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019517850" description="TNFR-Cys domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9686" checksum="D1F301F6DCF685FD" modified="2019-05-08" version="1">MPKIYFLWMCFMLISDQPEVNCCLQAQFLFQGNCCDMCPAGTLLTGYCGATTQTKCERCLEGTFTDQVHTLKTCYQCLECKGGKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXM2</accession>
    <name>A0A401PXM2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding protein 4.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0019332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014287">
        <property type="protein sequence ID" value="GCB77885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXM2"/>
    <dbReference type="STRING" id="75743.A0A401PXM2"/>
    <dbReference type="OMA" id="PECAYER"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12607">
        <property type="entry name" value="RRM2_RBM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000085">
        <property type="entry name" value="RNA-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034898">
        <property type="entry name" value="RBM4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB77885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38896" checksum="6B662334FC986F4E" modified="2019-05-08" version="1" fragment="single">NYGFVHMKDREAAKEAIENLHHYKLHGVSINVEASKGVSKISTKLHVGNVSGSCTSQELHAKFEEYGPVLECDIVKDYAFVHMERSEDAMEAIRGLDGTEFKGKRMQVELSKSRLRMQPGMGEKNGCFRCGKEGHWSKECPKDRGGLDGNFDGGFSRDYIDPYSMTARPITGYGERPLYDERYGVVDYYEKYRAGTYGAVGDPYGRAAPFSPLGTSLRDRIAAAVNPYERRPLTTPTTYFGRDRSPLRRPPPMPALSTGYGFERTTVSATVYDPTNSAARDPYATAQYSAAQYSAAHCRPVLCRPVLCILTERFALHRDESRGSLGTCRNSGHMFCLLVLAWKILARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY84</accession>
    <name>A0A401PY84_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NUMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014331">
        <property type="protein sequence ID" value="GCB78068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY84"/>
    <dbReference type="STRING" id="75743.A0A401PY84"/>
    <dbReference type="OMA" id="VTESKEC"/>
    <dbReference type="OrthoDB" id="10070446at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016698">
        <property type="entry name" value="Numb/numb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010449">
        <property type="entry name" value="Numb_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368">
        <property type="entry name" value="NUMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368:SF5">
        <property type="entry name" value="PROTEIN NUMB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06311">
        <property type="entry name" value="NumbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUMB" evidence="3">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="424" mass="45228" checksum="AC0AFD92ADBD354D" modified="2019-05-08" version="1" fragment="single">TGEVERNIVGTTPAPLPAAPSASPSAPTTITENKESSNIHAIPRRHAPVEQLARQGSFRGFPALSQTTSPFKRQMSLRINELPSTMQRKTDFQIKNTVPEMEGESIVEVDSISSLCSQITYAFSGQVEDPFSSAPMTKPAIGAAPQVTASQVNGAASTFPLPLPAPAAPTMSPTVMPVRDTNPWAQVPTTSTGTTIAARSNWGSAATVTTQFQPSHKRTPSEADRWLEEVSKGVRVHPAPQPLPQPSLAAPPAPQSFQVNTFVTSQATPVSLVPQMQPTFVPAQPYSVGVTNGVPYQAPRVPVVGITPSQMVANVFGTAGYIQVAHAQLKQNAFPQNEGTIMSITANPYFKPAQQINGSAAFNGAESGNWTTETKSIQMAAGIPEIDAFEAQWNALEYKSKQRATPSPTNPFSSDLQKTFEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYD2</accession>
    <name>A0A401PYD2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011723">
        <property type="protein sequence ID" value="GCB78154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYD2"/>
    <dbReference type="STRING" id="75743.A0A401PYD2"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32010" checksum="85C8197A0E3FB2EA" modified="2019-05-08" version="1">MTKVNRSLGLQQEQCLVHVLASNLQLTIIANQPGTTCKAGVWLPGANIATGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAGRTPEESERERREHEREERVVQTRSSATRVLPPGTGAGAVGNRLRNGQDAVLPTQASRAQQSANTSPRPISRAERERKVSMRLHRGAPANVSSSDLTARQDASRISASQTSMPFEHLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZS7</accession>
    <name>A0A401PZS7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0015859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009207">
        <property type="protein sequence ID" value="GCB78657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZS7"/>
    <dbReference type="STRING" id="75743.A0A401PZS7"/>
    <dbReference type="OMA" id="WEGHTRC"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="109" mass="11892" checksum="D01DE4A598EEAB19" modified="2019-05-08" version="1">MLGLREQQGGGPIDQGIDVTKVEVAGRKAIHFAADCGQLEVLEFLIHMGAEINAPDRHGYTALLSAIYEGHVDCVKFLVSKGANKTEKCPDGMSYFEVAESPEMRELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0Q1</accession>
    <name>A0A401Q0Q1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014531">
        <property type="protein sequence ID" value="GCB78938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0Q1"/>
    <dbReference type="STRING" id="75743.A0A401Q0Q1"/>
    <dbReference type="OMA" id="LAKRITX"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000024">
        <property type="entry name" value="Putative phosphoribosyl pyrophosphate synthase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF28">
        <property type="entry name" value="PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="279" mass="30851" checksum="F7FD92B22D53713B" modified="2019-05-08" version="1" fragment="single">RLGVELGKAVVYQEPNRETRVEIKESVRGQDIFIIQTISRDVNTAVMELLVMAYACKTSCARNIIGVIPYFPYSKQCKMRKRGSIVCKLLACMLAKAGLTHIITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQDEIHDYRNAIIVAKSPAAAKRAQSYAERLRLGLAVIHGEAQYAEYDMVDGRHSPPAVKNTSIHSGLELPLMMPKEKPPITVVGDVGGRIAIIVDDIIDDVDGFVAAAEILKERGAYKIYVMATHGLLSADAPCLIEESAINEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3E8</accession>
    <name>A0A401Q3E8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013482">
        <property type="protein sequence ID" value="GCB79888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3E8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="171" mass="16181" checksum="7441E936693794D2" modified="2019-05-08" version="1">MGETESVIGGAGAESMGGTESVIGRAGAESMGETESVIGGIGAVSIGETESVIGGVGAVNVGETESVIGETGAMRMGETDSVTGGTGAMSVGETKSVIGGAGAESMGETESVIRGTGAVSVGETESVIGGAGEESLGQTETVFGGTGAVSVGETETVIGGAGAVTIEKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q612</accession>
    <name>A0A401Q612_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027546">
        <property type="protein sequence ID" value="GCB80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q612"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="77" mass="8184" checksum="CA11F9D7E797EBE5" modified="2019-05-08" version="1">MWRDCEKLGLVSPEQDPCPSPARNHGDGISGTPSSAASPKGTMTPTRSWAVATTTPPCCSTARAAPPRFYAAMRQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6E8</accession>
    <name>A0A401Q6E8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023801">
        <property type="protein sequence ID" value="GCB80959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6E8"/>
    <dbReference type="STRING" id="75743.A0A401Q6E8"/>
    <dbReference type="OMA" id="RICRIQQ"/>
    <dbReference type="OrthoDB" id="9447519at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060091">
        <property type="term" value="C:kinocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026664">
        <property type="entry name" value="Stereocilin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412">
        <property type="entry name" value="STEREOCILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412:SF14">
        <property type="entry name" value="STEREOCILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="187" mass="20852" checksum="88DDB1F62F19C6CA" modified="2019-05-08" version="1" fragment="single">DVLTTEVVEMVLRSEGRWGVSDIGRICRIQQGRSAQTVLLSKKLSLATRVVKNIVKRRREGIPNCIDIKATFPTAWSSSQLAGMADSEFSDCLGILTSDQDLSAEHLKTLLTRTKQLYGSVRSMKPWQVLQLGQAVTQLSDRDLQDLDVSDLGILSFLGEMDEWNKKQTLWFPAASPWSVIRSGNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6L8</accession>
    <name>A0A401Q6L8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018668">
        <property type="protein sequence ID" value="GCB81044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6L8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="105" mass="11851" checksum="DA3F058EC7CE9DC7" modified="2019-05-08" version="1" fragment="single">QKHAAAQVGKECSKLVKIIGEENMKEIIQVPNEHKSKSEVANEDTKQLQKNEALEMENDEESVLESDSTVKTVGFQTNAPRIAINWVVKYVPESNGMAERWGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6X0</accession>
    <name>A0A401Q6X0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026520">
        <property type="protein sequence ID" value="GCB81144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6X0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="158" mass="16224" checksum="C4292F3174BDE1E7" modified="2019-05-08" version="1" fragment="single">MLSAVPHKTSQPEAVAPVCAEDTTSSEDQAPNEVILEASPVVLEASQVEAKVQVSTDVSALSEGQLSGEVAHQASPVSPGSSVVGTETQISTEHKINGVAIPTSPTAREVSQPDAQAYIEGLTSPSAQNKVPTVSHPDEGTSILTENDSSVAPRTCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7R6</accession>
    <name>A0A401Q7R6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01028003">
        <property type="protein sequence ID" value="GCB81412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7R6"/>
    <dbReference type="STRING" id="75743.A0A401Q7R6"/>
    <dbReference type="OMA" id="CSPHLNT"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="434" mass="50253" checksum="96F005DC98B5B9F0" modified="2019-05-08" version="1" fragment="single">DTGPGSPRLRYETWFTSTQIRDLVHLDSDTRPWCTSTQIRDLVHLDSDTRPWLTSTQIRDPGSPRLRYEALVHLVTNTRPRVRYEALVHLDSDTRPWSTSTQIRDLVHLDSDTRSWSTSTQIRDPGSPRLRYETLVHLDSDTRPCFTSIQVRDPGPPRLRYKTLDHLDSDTRPWSTSTQIRCPVSSRLRYEALVHLDSDTRTWSTSTQIRDPGPPRLRYETLVYLDSDTRTWSTSTQIRDPAPPRLRYEALAHLDSDTSPWFTLTQIRGPGPPRLRYEALAHLDSDTRPWFTLTQIRGPGSSRHRYETLAHLDSDTMPCFTSTQIRGPGSPRLRYEVLVHLESDTMPWSTSTQIRGPGSPRLRYKTLDHLDSDTRPWSTSTQIRCPVSPRLRYEALVHLDSDTRTWSTSTQIRDPGPPRLRYETLVYLDSDTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8D8</accession>
    <name>A0A401Q8D8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024258">
        <property type="protein sequence ID" value="GCB81648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8D8"/>
    <dbReference type="STRING" id="75743.A0A401Q8D8"/>
    <dbReference type="OrthoDB" id="10258119at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="53" mass="6120" checksum="D75888D1CF9ED534" modified="2019-05-08" version="1" fragment="single">LTGLLINRISFSVQGALEHEETKTLRIQLELSQIKAEIERKLAEKDEEIDTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8K0</accession>
    <name>A0A401Q8K0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019036">
        <property type="protein sequence ID" value="GCB81691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8K0"/>
    <dbReference type="OMA" id="PHERYVA"/>
    <dbReference type="OrthoDB" id="75908at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053901">
        <property type="entry name" value="C5orf34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027865">
        <property type="entry name" value="C5orf34-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053900">
        <property type="entry name" value="C5orf34-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34531:SF1">
        <property type="entry name" value="CHROMOSOME 5 OPEN READING FRAME 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34531">
        <property type="entry name" value="ZGC:153352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15016">
        <property type="entry name" value="C5orf34_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22834">
        <property type="entry name" value="Polo_box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C5orf34-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C5orf34-like C-terminal" evidence="1">
        <location>
            <begin position="136"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="378" mass="41846" checksum="49E090CC5A37F1F6" modified="2019-05-08" version="1">MLTKPGLSIPWCALGRCRTPVQLRGNILDYCRAITAPVNSVEIYPGDGSVLKPYGASSNYFIHYLMEQSGGQREERMYMVSSLPPDTPNSKYSICSMVTQAIRILQCGNQFKLSLKLPNVCCWKTVLSQPGVFSQLPVLLDEKMIRGVGRFSAHSDGQVHISFCDGMRLNTSWDFGSRHRGEARTSLQCKPVLSPVALSETQTNVKPGCCQLLFPDGSSQLVPMNSAGVYEGYITAAMDWCRWVSEGGREQTAVDHPNPRVNVQDENRSVIAELQKIQRFNFLLENSNCLKQGPVSHASPDLQPTETLSLCHEAGNQSVEMALRQTGRTIEDIELLLEVNKRSVKEMRGTRSAGIMGEQRDGVGNVPLVQQGLRALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Z9</accession>
    <name>A0A401Q8Z9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023069">
        <property type="protein sequence ID" value="GCB81852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8Z9"/>
    <dbReference type="STRING" id="75743.A0A401Q8Z9"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="11987" checksum="186A051C27BC24BD" modified="2019-05-08" version="1" fragment="single">MSEVGVSHGMLTFPLVVLICVHYLLKVHLDYCSLYGVEQGCNKDPDCVWCQSRCQSYQQHSACPHVGCIGLAPLLADCQSCLVFGQSRVSPPQGPGLLGWCVQTAGCFPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAU4</accession>
    <name>A0A401QAU4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0021630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019504">
        <property type="protein sequence ID" value="GCB82505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAU4"/>
    <dbReference type="STRING" id="75743.A0A401QAU4"/>
    <dbReference type="OMA" id="NIRFRPY"/>
    <dbReference type="OrthoDB" id="10010764at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF25">
        <property type="entry name" value="GLYPICAN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 12" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB82505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="9852" checksum="91DFD8A60CDD3366" modified="2019-05-08" version="1" fragment="single">MLLVAGRLEGPFNIESVMEPIDVKISDAIMTMQENSMQVSAKVFQGCGQPKLLHGRTSRSISESFNIRFRPYSPEEHPTTAAGTSLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDP6</accession>
    <name>A0A401QDP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01038726">
        <property type="protein sequence ID" value="GCB83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDP6"/>
    <dbReference type="STRING" id="75743.A0A401QDP6"/>
    <dbReference type="OrthoDB" id="10055808at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="65" mass="7876" checksum="F8A92B60DF1B7AC6" modified="2019-05-08" version="1" fragment="single">FVDEPERKYSFVCENKDECEEWIEALTKASYEYMRESLIFYRHEIKKITGKVSECSLAFQSTIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEV4</accession>
    <name>A0A401QEV4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01057373">
        <property type="protein sequence ID" value="GCB83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEV4"/>
    <dbReference type="OMA" id="SEVNCER"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="148" mass="17330" checksum="9C8AA72ADECDB947" modified="2019-05-08" version="1" fragment="single">MVGDWQSEVNCERETKREPDRQPERESESESRQSESESQTEREREPDRARARARQSERESKSESERESEIERESESESESERESERESESKSKSKSESESQTERAREREPDRARARQSESQSQTESQSQTESQSQTESQSQTESQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFS1</accession>
    <name>A0A401QFS1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunoglobulin subtype domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01061430">
        <property type="protein sequence ID" value="GCB84268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFS1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019295862" description="Immunoglobulin subtype domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11082" checksum="9E1669367C945595" modified="2019-05-08" version="1" fragment="single">MSTIRWGLFLAGFLLTCSLGESSESHLEWKEIILQPSSNITLNCSGDCHIEWTYDEGGDVQPDGRFLHIYNATTKHNREYNCSCNKTEITSFYIFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG84</accession>
    <name>A0A401QG84_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01074929">
        <property type="protein sequence ID" value="GCB84394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG84"/>
    <dbReference type="STRING" id="75743.A0A401QG84"/>
    <dbReference type="OMA" id="DWSAGAC"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02389">
        <property type="entry name" value="Cornifin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="113" mass="10972" checksum="4A45D041803A1916" modified="2019-05-08" version="1" fragment="single">ACADRGAGACTDWSAGACADRGLEPAQTGALELAQTGALEPAQTGGLEPAQTGALEPAQTGALEPAQTRALEPAQTGALEPAQTGALEPAQTGLEPAQTGALEPAQTGALEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGE6</accession>
    <name>A0A401QGE6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01075197">
        <property type="protein sequence ID" value="GCB84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGE6"/>
    <dbReference type="STRING" id="75743.A0A401QGE6"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8289" checksum="6A96E5659EE77F8B" modified="2019-05-08" version="1" fragment="single">DNKEEAISDCTKAIELNPNYIRAILRRAELYEKSEKLDEALQDYKTILEKDPSVGQARDACMLSHTVTIGFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGU1</accession>
    <name>A0A401QGU1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01086238">
        <property type="protein sequence ID" value="GCB84599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGU1"/>
    <dbReference type="OrthoDB" id="8931496at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="41" mass="4529" checksum="7F4BAB21C4166D62" modified="2019-05-08" version="1" fragment="single">MQGLSRPLSRGLRFLIADSRRQLIPRAGIVAKPAKEKLTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHJ6</accession>
    <name>A0A401QHJ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0025462</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01097313">
        <property type="protein sequence ID" value="GCB84812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHJ6"/>
    <dbReference type="STRING" id="75743.A0A401QHJ6"/>
    <dbReference type="OMA" id="FACARKE"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000123">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
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        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB84812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="391" mass="42919" checksum="ACB1417881F61BE5" modified="2019-05-08" version="1" fragment="single">MSSPSLCDGGAKGQMQFAEGSQETKPLTCPLCTFITESAEAFEQHQALHGNMRLYEELAPPVKQEPGGEWWPPYDGEEPSPLASDGSDGLGPRGGYGWDLQQDEGKPLDRQWGYPEGQSPGGDAKRNGQPKASAGFLSGGGLVGGEQPMLNFKVVVVGEEGGQGRRRRGGGCEGREPPPAEEELGSQRHDPFPGGLPGYEGEPEQEGEQAALSGESSPGSRPSASDPRASQSKQKWQSKQYQCDLCPYVARGKQDLRIHEREEHLKEGSDVIKCSQCNYTTNKISFWRQHKLVHISANGSTGRIYMCKTCGWKTKYRHSLVKHIALHTGNKSFQCDQCGFACARKENLKRHKLTHLKKGVDGKGLMLKCNWCEYATAHSNALRRHAMTLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIH8</accession>
    <name>A0A401QIH8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0025884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01136594">
        <property type="protein sequence ID" value="GCB85162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 3"/>
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    </dbReference>
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        <property type="entry name" value="LD25575P"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB85162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="77" mass="8776" checksum="9C119C1F37582A32" modified="2019-05-08" version="1" fragment="single">GDPDNYIAYYRRATVYLAMGKSKSALPDLSKVIELKPDFTSARLQRGNLLLKQGKLDEAEEDFKKVVSLYMCRAVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKL2</accession>
    <name>A0A401QKL2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
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                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01220089">
        <property type="protein sequence ID" value="GCB85951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QKL2"/>
    <dbReference type="OMA" id="CVSNTCV"/>
    <dbReference type="OrthoDB" id="10609604at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="180" mass="19497" checksum="8CE932258226E43A" modified="2019-05-08" version="1" fragment="single">NLIDVCNTSVLCIDNLIDVSDTSVLCTDNLIDVCDTSVLCIDNLIDVCNTSVLRIDNLIDVSDTSVLCIDNLIDVSDTSVLCIDNLIDVCDTSVLCIDNLIDMRDTSVLCIDNLINVSDTSVLCIDNLIDMRDTSVLCIDNLIDVSDTSVLCIDNLIDVCNTSVLCIDNLIDVQIPLSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLK2</accession>
    <name>A0A401QLK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01266013">
        <property type="protein sequence ID" value="GCB86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLK2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="125" mass="15356" checksum="A4F48D0F3149ED38" modified="2019-05-08" version="1">MKEGERERNKMKEYERERNETMEEEGERNERKEGKRERNEMKEGTRERNETMEGERERNDTKEGERERNETKEGERGRNEMKDGERERNETKEGEGERNEMKEGERERNELKVGERERNKTKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMY5</accession>
    <name>A0A401QMY5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01342116">
        <property type="protein sequence ID" value="GCB86777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMY5"/>
    <dbReference type="OMA" id="CAGLSWS"/>
    <dbReference type="OrthoDB" id="10636710at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="19049" checksum="1A54832B28114C6F" modified="2019-05-08" version="1">MLQGLSARVHVLQEMSAGVHVLQVLSARVHVLQRIAAGVYVLQGLSARVHVLQGISARVHVLQGMSAGVHMLQGLSARVHVLQGISAGVHVLQGISARVHVLQEMSAGVHMLQVLSARVHVLQGISAGVYVLQGILADVYVLQGISAGVHVLQGISADVYVLQGISAGVHVLQGISARVHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNT9</accession>
    <name>A0A401QNT9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01384454">
        <property type="protein sequence ID" value="GCB86992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNT9"/>
    <dbReference type="OMA" id="DCDIANP"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="18922" checksum="F86DB025DEE24D86" modified="2019-05-08" version="1" fragment="single">NPLSDWDIANPLTDWDIVNQLSDCDIVNPLSDCDIANTVTDCDIANPVSDCDIADPLSDWDIANRLSDCDIANALSDCDIANPLCDCDIANTLSDWDIANPLSDCAIVNPLSDWDIANTLTDCDIANPLSDCAIVNPLSDWDIANQLSDWDIANPLSDCDIANPLSDGDVINPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QP17</accession>
    <name>A0A401QP17_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01417673">
        <property type="protein sequence ID" value="GCB87106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QP17"/>
    <dbReference type="STRING" id="75743.A0A401QP17"/>
    <dbReference type="OrthoDB" id="10004365at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="13844" checksum="07C181813B371D94" modified="2019-05-08" version="1" fragment="single">MDGNEEVDGNGEVDGNGEVDGNGEVDGNGEVDGNGEMDGNGEVDDNGEVDGNGEVDGNGEVDGNGEVDGNGEVDGNGEMDDNGEMDGHGEMDGNGEVDGNGEMDGNGEMDGNGEMDGNGEVDGNGEVDGIGEVDGNGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NG29</accession>
    <name>A0A401NG29_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007368">
        <property type="protein sequence ID" value="GCB59766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NG29"/>
    <dbReference type="OMA" id="DSEMRSQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB59766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="17630" checksum="40EECE78BB743BED" modified="2019-05-08" version="1" fragment="single">APVIAAHVVADTATAAPAVAAPVVPGIATAAPVVPAPVVADTATAAPVVAALVVVALVVAAPVVPGTATAAPVVADIACAAPVVAALVVPGTATAAPVVAAPVVADTAIAAHVAAPVVNDPIVPDTAAVAPVLLLLLLLLLLLLILLFLVLLQLLLLLLLLLLLILLLLLILLLILLFVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGV7</accession>
    <name>A0A401NGV7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">Follicle-stimulating hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">Follitropin receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FSHR</name>
        <name evidence="18" type="ORF">scyTo_0009090</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003623">
        <property type="protein sequence ID" value="GCB60004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGV7"/>
    <dbReference type="STRING" id="75743.A0A401NGV7"/>
    <dbReference type="OMA" id="PFVKCTP"/>
    <dbReference type="OrthoDB" id="5981530at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004963">
        <property type="term" value="F:follicle-stimulating hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000019">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002272">
        <property type="entry name" value="FSH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF5">
        <property type="entry name" value="FOLLICLE-STIMULATING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01143">
        <property type="entry name" value="FSHRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="301"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB60004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="635" mass="71996" checksum="ADBA685751D3778B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIJ7</accession>
    <name>A0A401NIJ7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004997">
        <property type="protein sequence ID" value="GCB60702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIJ7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="55" mass="6357" checksum="C9562BE5290853AC" modified="2019-05-08" version="1" fragment="single">MGQTSLGAPTVPLWAAVQQKNRREREGARELQRRASPFRDSFTVEKRSQVRFRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJX0</accession>
    <name>A0A401NJX0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0009294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003760">
        <property type="protein sequence ID" value="GCB61176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJX0"/>
    <dbReference type="STRING" id="75743.A0A401NJX0"/>
    <dbReference type="OMA" id="PKETHDK"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13295">
        <property type="entry name" value="PH_EFA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000004">
        <property type="entry name" value="PH and SEC7 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000054">
        <property type="entry name" value="PH and SEC7 domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF329">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="8">
        <location>
            <begin position="52"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="198"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB61176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="53257" checksum="BB79E6963C6F89FE" modified="2019-05-08" version="1">MEDSTEHLEHGSTDTLANGCKTDIDPAKRLAKRLYNLEGFKRCDVARHLGKKRFLKAFPLMGETQERERVLIHFSKRYCQCNPDCINSEDGVHTLICALMLLNTDLHGHNIGKKMSCQQFISNLDSLNDGKDFPKDLLKGLYNSIKNEKLEWAVDEDELRKSLSELVDDKYDSCPKKVTRIIDSSNPFLDIPQALNAATYKHGVLNRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYKLDRDLSEVDLKNAIRIHHALATKAIDYSKRPNVLKLKTADWRVFLFQAPSEEEMHSWILRINLVTAIFSAPSFPAAIGSLKKFSRPLLPSSTTKLSQEEQLKSHWTKWRQISAELAEHSTHPPEKNVKSKDTEEYRLKEHYLLFEKSRYEAYINLLKAKLKVGTDDLEKIEAIIFSFENDENSLRKTQSSPSLNQGHFSLNGKMEKDITEQKCYPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKB8</accession>
    <name>A0A401NKB8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA wybutosine-synthesizing protein 2 homolog</fullName>
            <ecNumber evidence="2">2.5.1.114</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0007033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002473">
        <property type="protein sequence ID" value="GCB61328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKB8"/>
    <dbReference type="STRING" id="75743.A0A401NKB8"/>
    <dbReference type="OMA" id="CACEELC"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000002">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056745">
        <property type="entry name" value="TYW2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25132">
        <property type="entry name" value="TYW2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="10">
        <location>
            <begin position="119"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB61328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="471" mass="52994" checksum="B5C001E4F0191728" modified="2019-05-08" version="1">MQTEVSAIVTPAQFAQQYRQYLETNGILDSAYRLQKQPGGSVALPVLCNKLSQLHLLSLCDTVAPGSTCIFTQVKNPILSKKSSVKSCHQRLQEELHELVKLSGVLWNDQLSCDLPQVWKRHGDMIVLNENAFQADIWKTLEPEVWLVVANALGVKRIAKAGRVSADGFRTPKVTLLLGNDAWVHHIDNGIRYTFDVTKCMFSSGNITEKLRVSSFDCTGEVVVDLYAGIGYFTLPFLMHAGAAFVHACEWNPHAVAALVKNLELNKVSHRCKIHKGDNQQLPLRNLADRVNLGLIPSSEEGWPIACQLLRENRGGIFHIHHNISLYAENRGAAVDRKNLVEGRCKEQEQSLTAMLPASWTERTKSSSDSTTPAFTCLCAKESILNSRWKGPGNRLKVETNCGTYCEKRIFIHPEWQSWAESVALRIKNLLEILHQKQWRTNILHIEHVKSYAPHIDHVVLDLECRPCDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKK5</accession>
    <name>A0A401NKK5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001178">
        <property type="protein sequence ID" value="GCB61379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKK5"/>
    <dbReference type="STRING" id="75743.A0A401NKK5"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030548">
        <property type="entry name" value="RAD51B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46456">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46456:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19162" checksum="7F3D4A0982DEB510" modified="2019-05-08" version="1">MMGSTSEQLSLLIERLSGVHDVVILTNQITTRLNQNRAACSVPGSGVGDSLLPEDCGVSPDGETSYATAALGNTWSHSVNTRLIMQYLDYHSRQIIIAKSPLAPFALFVFTIQDAGLALQETKAAAVGYDLTMITGPNSLRTPMLGNGQTVHTGDLMALIVFIYSRYSATKEVAVNAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLV7</accession>
    <name>A0A401NLV7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0009408</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003837">
        <property type="protein sequence ID" value="GCB61840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLV7"/>
    <dbReference type="STRING" id="75743.A0A401NLV7"/>
    <dbReference type="OMA" id="HDMIATE"/>
    <dbReference type="OrthoDB" id="8872930at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000001">
        <property type="entry name" value="CBFA2/RUNX1 translocation partner 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1110:FF:000001">
        <property type="entry name" value="RUNX1 translocation partner 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013290">
        <property type="entry name" value="CBFA2T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013289">
        <property type="entry name" value="CBFA2T1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014896">
        <property type="entry name" value="NHR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379">
        <property type="entry name" value="MTG8 ETO EIGHT TWENTY ONE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379:SF5">
        <property type="entry name" value="PROTEIN CBFA2T1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08788">
        <property type="entry name" value="NHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01875">
        <property type="entry name" value="ETOFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01876">
        <property type="entry name" value="MTG8PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
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                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
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                <person name="Kiyatake I"/>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1430" mass="158647" checksum="593F18A8502DA07B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNC0</accession>
    <name>A0A401NNC0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein TMEM103</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0007216</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002569">
        <property type="protein sequence ID" value="GCB62344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNC0"/>
    <dbReference type="STRING" id="75743.A0A401NNC0"/>
    <dbReference type="OMA" id="KMGCNLT"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001078">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB62344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="286" mass="32072" checksum="BF7A2255C3C6A6B4" modified="2019-05-08" version="1">MFWREHPPNGEIISGNQENERAVAFSLTNVCFSSKQGKVVLLCDKLTDGTFLVHHFLSFYLKGGCKVCFLGLVQSFNHYNLVAQKLGVHLSAAREKGQLVFLEGLRSSLDLILNDGQESTQQILSPLQFLSSPNASLQCLYDFVRVSLQETSETPWRFPVLIIDDLSVLLSLGVSPVNIMNFLHYCRATVCSKFMGNIVTLVHNTEDLEDEENNFVVKSLSHQCHMILQVEGLTTGYCKDIHGQLTMTCRSPSPVKSEKNVNKIFQYKIQDKNVTFFARGTSSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNG4</accession>
    <name>A0A401NNG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gap junction epsilon-1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Connexin-23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0000027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the connexin family. Beta-type (group I) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000004">
        <property type="protein sequence ID" value="GCB62394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNG4"/>
    <dbReference type="STRING" id="75743.A0A401NNG4"/>
    <dbReference type="OMA" id="WLQIYLF"/>
    <dbReference type="OrthoDB" id="8719005at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000004">
        <property type="entry name" value="Gap junction epsilon-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF1">
        <property type="entry name" value="GAP JUNCTION EPSILON-1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="13">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="205" mass="23686" checksum="34A70D270186D74A" modified="2019-05-08" version="1">MSLNYIRNFYEGCLRPPTVIGQFHTLFFGSVRMFFLGVLGFAVYGNEALHFSCDPDRRELNLFCYNQFRPITPQVFWALQLVSVLVPGAVFHLHAACRNIDQEVILQRPAFTVFYIISVLSRIILETVAFWLQSHLFGFQVHPVFRCNATSLDKHFNITKCMVPEHFEKTIFLSAMYTFTAITVLLCVAEVFEILCRRLGYFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNM4</accession>
    <name>A0A401NNM4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein 48</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">USP1-associated factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0007246</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002583">
        <property type="protein sequence ID" value="GCB62508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNM4"/>
    <dbReference type="STRING" id="75743.A0A401NNM4"/>
    <dbReference type="OMA" id="IIRVWHT"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000054">
        <property type="entry name" value="Putative WD repeat-containing protein 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002031">
        <property type="entry name" value="WD repeat domain 48b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB62508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="582" mass="65233" checksum="DA08AC303C67C293" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP54</accession>
    <name>A0A401NP54_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NF-kappa-B inhibitor alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">I-kappa-B-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0014521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NF-kappa-B inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007822">
        <property type="protein sequence ID" value="GCB62653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP54"/>
    <dbReference type="STRING" id="75743.A0A401NP54"/>
    <dbReference type="OMA" id="GRQNEQI"/>
    <dbReference type="OrthoDB" id="10254947at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="323" mass="35999" checksum="61FAF93D2B709B4C" modified="2019-05-08" version="1">MAQFAAGYRQGQDRSRNAKLLEPKLALEGERLDSGIDSMQEPEESLDSVTDRVDNLNIGSWGVEQQQPTQGWATFRSEDGDTFLHLAILHLRPDIASFLLWSERSVINVCNKSRQSPLHLSVIMRMPGLTGELVQAGADLETLDTFGNTALHLACEQGDPDCVNSLLDLTGTSNVTQQHREQDLEWRNFCGHACLHIAAMKGDCEIVERLLALGANINAQEPSSGRTPLHLAVEFQHREVVQLLIEHGADVNRLMYNSCTAFHLTAGRPDLEIREQLSQLTSSSLIPLYESSDSESEAEWDTRSDCEMPPDYDDLQIRGHSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPQ1</accession>
    <name>A0A401NPQ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="15">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0007293</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54256"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:13840"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138021"/>
            <dbReference type="EC" id="1.14.11.79"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidyl-[ribosomal protein uL15] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54024"/>
            <dbReference type="Rhea" id="RHEA-COMP:13760"/>
            <dbReference type="Rhea" id="RHEA-COMP:13761"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138021"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="15">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ROX family. MINA53 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01002614">
        <property type="protein sequence ID" value="GCB62853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPQ1"/>
    <dbReference type="STRING" id="75743.A0A401NPQ1"/>
    <dbReference type="OMA" id="IRREMVY"/>
    <dbReference type="OrthoDB" id="425950at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032453">
        <property type="term" value="F:histone H3K4 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036139">
        <property type="term" value="F:peptidyl-histidine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1500">
        <property type="entry name" value="JmjC domain-containing ribosomal oxygenase (ROX), dimer domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046799">
        <property type="entry name" value="ROXA-like_wH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF7">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20514">
        <property type="entry name" value="WHD_ROXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="146"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB62853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="476" mass="55068" checksum="DAC773D440EBCC9F" modified="2019-05-08" version="1" fragment="single">RASPAMLKKVGRKPESDSEREDADLCKRVKLDPDVSSIALNFKSPASLFESLISPIGSKEFFNEYWEQKPLLIQKNDPSVAAYYQSLFKFDDLKEICKDDVFYGRDVNFCRCTSGKKKVLNKDGKVNYTQLQKDFEQKKATIQFHQPQRFKDELWKIQEKLECFFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYKPTKPLAREYSIEPEDRIGSPTHEFTLKPGDLLYFPRGTIHQADTPTGGSHSTHITISTYQNNTWGDYLLDVIPWLVYDTMKEDIELSRGLPRQYLMQMNSSTDSARKLSEFLRGLADQVENGKETRSSEMKKDFILNRLPPYMSNTSDCLTQAGKLPKLNDQIKLRFKDHTMILVEHDQERTDESREMMVYVYHSLKNSRENHMMGAEDNEEEESFQAHGLRFSWSHLEALKQLWTDDTVPVSDLKLDSDKAKENLALCLWTENLIEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSC8</accession>
    <name>A0A401NSC8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004047">
        <property type="protein sequence ID" value="GCB63808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSC8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="300" mass="33480" checksum="22E9F91D6BF3A489" modified="2019-05-08" version="1">MPAPKSSTPRTHAGEKPFQCKLANNAQEHSLTGGRVPYIKELTEQEEFTRKLFGLSNPMITNGGSDMGMSEDTQVFMGTSDGDGGELTAASEIPERADEEGAEVNTSQQCGMAAAMEEGEECQGAKMSDMDGSVSEFKLNIKVCVKEEACDDLAAKVEGGRSEPSRGEEPGALKAEAPPSPQGQYQAYSAVEENEIDLKPLEHLYQEQVQSTESYQATCNLPQQILTEFKTDVSQNLQRNNEILQQHLQRNNEILQQHLQRDNEILQQHLQRNNEILQQHLQRDNEILQQHLQRDNEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT04</accession>
    <name>A0A401NT04_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Exocyst complex component 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exocyst complex component Exo70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004061">
        <property type="protein sequence ID" value="GCB63974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT04"/>
    <dbReference type="STRING" id="75743.A0A401NT04"/>
    <dbReference type="OMA" id="SNTIWFL"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="341"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="707" mass="81145" checksum="D5982E7B15A1F72B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT85</accession>
    <name>A0A401NT85_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOCKER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0000238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000042">
        <property type="protein sequence ID" value="GCB64096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT85"/>
    <dbReference type="STRING" id="75743.A0A401NT85"/>
    <dbReference type="OMA" id="NAERMNT"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF6">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="4">
        <location>
            <begin position="281"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB64096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="894" mass="104638" checksum="95F4944EE2F00567" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTB6</accession>
    <name>A0A401NTB6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lysine-specific demethylase</fullName>
            <ecNumber evidence="14">1.14.11.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0007488</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60188"/>
            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.</text>
    </comment>
    <comment type="domain">
        <text evidence="14">The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the JHDM2 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.65" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01002726">
        <property type="protein sequence ID" value="GCB64128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NTB6"/>
    <dbReference type="OMA" id="SIVPVEF"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140683">
        <property type="term" value="F:histone H3K9me/H3K9me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000004">
        <property type="entry name" value="Putative lysine-specific demethylase 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054294">
        <property type="entry name" value="DUF7030"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054503">
        <property type="entry name" value="KDM3AB_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054504">
        <property type="entry name" value="PWWP_KDM3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF8">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22989">
        <property type="entry name" value="DUF7030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22988">
        <property type="entry name" value="PWWP_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22987">
        <property type="entry name" value="Tudor_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 14" id="KW-0408">Iron</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="1682"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="268"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="418"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="535"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="853"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1014"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1303"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1415"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1458"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1307"/>
            <end position="1333"/>
        </location>
    </feature>
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        <location>
            <begin position="1370"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1426"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1460"/>
            <end position="1474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037987"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB64128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1953" mass="214754" checksum="FB61C3A2B2B37A39" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU55</accession>
    <name>A0A401NU55_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002748">
        <property type="protein sequence ID" value="GCB64387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU55"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="17127" checksum="C11B6C4CB8DCF459" modified="2019-05-08" version="1">MFTCNSCTEYMAIWSLRRYTSSDGNPLTTKPLLEKIVAAIGEGGDRYIHKVKAHSKTEPRAEGNQRADQFAKEGARTSVTWDPYEEGQVAAVRGQPEEKRSTGVVLAPDLGTVQAQDPILKATLTAIPRQEKVECPYRAADVAVKEGMLFKGDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVW1</accession>
    <name>A0A401NVW1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006831">
        <property type="protein sequence ID" value="GCB65018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVW1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10569" checksum="1A1A0806B9087E01" modified="2019-05-08" version="1">MEMCRWKLDKLPEQQGSPASQESPPSPLPPPLPAAPERETGIYLGQYRNASRSVMQSALRLKVPHIESLGCRGLNKVWNEMEQPAHINHFKHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXF9</accession>
    <name>A0A401NXF9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Methyltransferase-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">METTL1</name>
        <name evidence="20" type="ORF">scyTo_0014906</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Forms a complex with WDR4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="18"/>
    <dbReference type="EMBL" id="BFAA01008185">
        <property type="protein sequence ID" value="GCB65544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXF9"/>
    <dbReference type="STRING" id="75743.A0A401NXF9"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:C21-steroid hormone biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071375">
        <property type="term" value="P:cellular response to peptide hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034650">
        <property type="term" value="P:cortisol metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:vitamin D metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20648">
        <property type="entry name" value="CYP27B1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 302a1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYP11_CYP27_families"/>
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    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF121">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 27 SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0349">Heme</keyword>
    <keyword evidence="14 19" id="KW-0408">Iron</keyword>
    <keyword evidence="11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 18" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="18">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB65544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="841" mass="97579" checksum="221DD21B12AAA751" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0Y4</accession>
    <name>A0A401P0Y4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002964">
        <property type="protein sequence ID" value="GCB66771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0Y4"/>
    <dbReference type="STRING" id="75743.A0A401P0Y4"/>
    <dbReference type="OMA" id="PRVEHNT"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="231" mass="26397" checksum="FF3D799E55D8B791" modified="2019-05-08" version="1">MAAAVEVEAEIANDEEQESEIPQQEIRQQSLQMEYKYKEEGEVLVGPVVEDGRNNDIKNVLPEKIEEKAVHLDEENSGQVETERIKHCENAEHSKEQVEAIKKDSAQKYLAEEDTTSEEEFCDVDLSEFGIELSVSESDVSFSSQQFLVLDESAASSHTSSQLSTSADLDQIPAQRNWKRTVLLMWKEIASHRFASLFLNPVTEERVPGYHSRVRRSRLPYRPIAMKDQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1S6</accession>
    <name>A0A401P1S6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor GTPase-activating protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0013649</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007068">
        <property type="protein sequence ID" value="GCB67043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1S6"/>
    <dbReference type="STRING" id="75743.A0A401P1S6"/>
    <dbReference type="OMA" id="APKEESX"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
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    </dbReference>
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        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="19">
        <location>
            <begin position="60"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
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            <begin position="189"/>
            <end position="200"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039243"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB67043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="556" mass="62227" checksum="3F8F0644FE557DAF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2I6</accession>
    <name>A0A401P2I6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008406">
        <property type="protein sequence ID" value="GCB67331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401P2I6"/>
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    <dbReference type="OrthoDB" id="548867at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
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        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="184" mass="21184" checksum="ABBBAA1B4C4B1D88" modified="2019-05-08" version="1" fragment="single">TSEADVEAVMDKLFDELAQKQNDITRPRILKVQGRELRLSKACGTIADCTFEELCDKPLGASDYLEMAKYFDTVFIRNIPMLTLAKKAQARRLITLIDAFYDNKVRVICSAALPLESLFVQKDNDSQEDDARECIDDLELDHTKVEDISIFSGSEEIFAFQRTISRLTEMQTKQYWNEGDRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2M8</accession>
    <name>A0A401P2M8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SKICH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0000714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000145">
        <property type="protein sequence ID" value="GCB67356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2M8"/>
    <dbReference type="STRING" id="75743.A0A401P2M8"/>
    <dbReference type="OMA" id="PFCFRNP"/>
    <dbReference type="OrthoDB" id="10015001at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051002">
        <property type="entry name" value="UBA_autophagy_assoc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31915:SF10">
        <property type="entry name" value="CALCIUM-BINDING AND COILED-COIL DOMAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31915">
        <property type="entry name" value="SKICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKICH" evidence="4">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="280"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB67356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="598" mass="69194" checksum="4A223C515C27F164" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P379</accession>
    <name>A0A401P379_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATR-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004390">
        <property type="protein sequence ID" value="GCB67584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P379"/>
    <dbReference type="STRING" id="75743.A0A401P379"/>
    <dbReference type="OMA" id="CALAQHH"/>
    <dbReference type="OrthoDB" id="6428926at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ATRIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594:SF1">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="100286" checksum="ACC3CD534B238683" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3K1</accession>
    <name>A0A401P3K1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine zipper protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000156">
        <property type="protein sequence ID" value="GCB67719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3K1"/>
    <dbReference type="STRING" id="75743.A0A401P3K1"/>
    <dbReference type="OMA" id="CGIHTEE"/>
    <dbReference type="OrthoDB" id="8767066at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026718">
        <property type="entry name" value="Luzp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22414">
        <property type="entry name" value="LEUCINE ZIPPER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22414:SF0">
        <property type="entry name" value="LEUCINE ZIPPER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31435" checksum="79D77E0D82C1B012" modified="2019-05-08" version="1">MKGNLQILTDCAISSFTKPFQALKTDEAVAQNDVQKLLEISQKQKDEMKSLQETLQKQINEAALKAEKQQAGINFLKTEVERKTKLIKDLQQENKSLKNKLLSGNKWCGIHAEESKRIQSQLKELRYGKKDLIFKAQQLTDLEHKLLAAKQELEKTAGDKEAQLKALKEVARLCVSGVLKNQPPFLSINPPRTTENGMLSTKNNSQLPFHQANRKLLDIPQTEIVTLAVLARIVRRIKTIILPRSRNTEASSSLQMKTDSSSRLRNEPQKTEQDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P532</accession>
    <name>A0A401P532_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OCA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007193">
        <property type="protein sequence ID" value="GCB68190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P532"/>
    <dbReference type="STRING" id="75743.A0A401P532"/>
    <dbReference type="OMA" id="HPASMYY"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070974">
        <property type="term" value="F:POU domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000097">
        <property type="entry name" value="NF-kappa-B inhibitor zeta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047571">
        <property type="entry name" value="OCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF5">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52003">
        <property type="entry name" value="OCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCA" evidence="8">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="588"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="658" mass="72614" checksum="E9AED237EE6A7109" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P669</accession>
    <name>A0A401P669_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005906">
        <property type="protein sequence ID" value="GCB68651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P669"/>
    <dbReference type="STRING" id="75743.A0A401P669"/>
    <dbReference type="OMA" id="KQCPVIY"/>
    <dbReference type="OrthoDB" id="8875634at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000001">
        <property type="entry name" value="Testican-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF21">
        <property type="entry name" value="TESTICAN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="185"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="223"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="307" mass="35102" checksum="E70577EF64E22727" modified="2019-05-08" version="1">MASLPCLNVKAHIYKTKCSDREFKEVVLSLKDWFKVLHENGNHNKKARGIQRQAKDRIKQGESTGQQHAFEGHQSPEHQLEASIRTDTETLQHLYSGVDKGTHNEGQNAGGFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELGSIYVDNHDHCIKPFFNSCDTYRDSRISNNEWCYCFQRNQDPPCQMELSNIQRQQRGKKLLGIFLPTCDEDGYYKATQCHGSVGQCWCVDRYGNEMRGSRSSGSPDCGGDIEISGDFGSGDFHEWSDDEDDEEDTNDEEEDDEVDNEDDEDDDDEYDVGGYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6B0</accession>
    <name>A0A401P6B0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Huntingtin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007250">
        <property type="protein sequence ID" value="GCB68679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6B0"/>
    <dbReference type="STRING" id="75743.A0A401P6B0"/>
    <dbReference type="OMA" id="HASNTRI"/>
    <dbReference type="OrthoDB" id="10065698at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048413">
        <property type="entry name" value="Htt_C-HEAT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20927">
        <property type="entry name" value="Htt_C-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122691" checksum="738CFF7AB9F034D5" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6G3</accession>
    <name>A0A401P6G3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein naked cuticle homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0005350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Cell autonomous antagonist of the canonical Wnt signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001654">
        <property type="protein sequence ID" value="GCB68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6G3"/>
    <dbReference type="STRING" id="75743.A0A401P6G3"/>
    <dbReference type="OMA" id="XELQCDV"/>
    <dbReference type="OrthoDB" id="5953812at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000166">
        <property type="entry name" value="Naked cuticle homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040140">
        <property type="entry name" value="Nkd-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22611">
        <property type="entry name" value="PROTEIN NAKED CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22611:SF2">
        <property type="entry name" value="PROTEIN NAKED CUTICLE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="465" mass="53292" checksum="A131249D3173AC27" modified="2019-05-08" version="1">MGKLHSKHAAVCKPRESPEGDSFVVNACLSRKGLEDWIVKQKHSPGYSAGFQRAGCRLSTAGSAGEFSREGYSEEHYPLEVALPPENTDGFNNTVEKKMEKEGAGQSGVKKQLKFEELECDVSVEEDNRQEWTFTLYDFDNNGKVTREDITSLLHTIYEVVDASVNHSPSTSKTLRVKLTVTPDASQKKKGNHTGQTDVNNSWQKAENKCVEESKNMEKKVRATLRRQNSDQHPQQINCHRHCVDENIERRNHYLDLAGIENYTSKFGPGSPPVASRKENHVKVSHHARSHSHDPEIMHSHHRRYQTMDPGHSHLNHSSYSRMIELQQRLRNQDTSKHLVKSPKTLSKNVMASVPAGKVGKSKPSQSPYMPMTSTPVVVSPNIPYRPMQLGQQHQQSHKKHKQRSKDNHQIYKAFQPPSRVVEQEHVRDLPSLMLYEGHVGRIVQRHEHHHHHEHHHHYHHFYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7L9</accession>
    <name>A0A401P7L9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0013919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007303">
        <property type="protein sequence ID" value="GCB69115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7L9"/>
    <dbReference type="STRING" id="75743.A0A401P7L9"/>
    <dbReference type="OMA" id="PIQYVLK"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03723">
        <property type="entry name" value="SOCS_ASB4_ASB18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF173">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB69115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="383" mass="43347" checksum="D1601805054BB9B4" modified="2019-05-08" version="1">MELLQRFGIFTGYKLNFGKRYWLPSYKLGSSWTTGLHLSVMLGNLECIAVLLDHQANINYQPNGKAPLHVAIDVKNRDCVSLLLHHGAKINCFSLSGHTPLHLCRTKESISCAKLLIWNGANLNLQANHDYKDTPMHIAARFGVPELVALYVDHGADIDSVNVYLETPLISAIYWTLNMKEQQYSTDHHLICRMLIDYGASVNARDQDYKTPLHKAAWNCDHLLLQMLLESGAQAGSMDVNGCASLQYLLKVTPVRPAAEPEKCYQLLLNHGAARVYPPHFHKVLQSCCTCPKAVEVMVNSYESIQSTSKWRQVIPDHILEQHWTFYKSLFDVCGGSARSLMHLTRCTIRAVLRKRCHNAVPKLNLPPRLKKYLLLEPEGVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8B3</accession>
    <name>A0A401P8B3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0008375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003190">
        <property type="protein sequence ID" value="GCB69375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8B3"/>
    <dbReference type="STRING" id="75743.A0A401P8B3"/>
    <dbReference type="OMA" id="HACEHRR"/>
    <dbReference type="OrthoDB" id="3069995at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001098">
        <property type="entry name" value="Ras responsive element binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003009">
        <property type="entry name" value="Ras-responsive element binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002109">
        <property type="entry name" value="ras-responsive element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052795">
        <property type="entry name" value="RREB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451:SF1">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="504" mass="53689" checksum="BA6C113DD4B3FC3A" modified="2019-05-08" version="1">MYYVGGRLRGQKPYPCPKCDAYFSTKSNCERHLLRKHGVANRSLRRNGLIARCKATDAKPLESTGNHSDSEAAGHATAPAATPTCPSPSATERPPADGAAGPGQPEEELLEECAGGGRRKDGKLEEEAEEDAQSNKSLDLNFASKLIDFKLGGPNPSGGDAGAQQEGRNTCTVCGKTFKYAATLARHRKAHACEHRRDGKAGRRGPRSVAGRAAAAPEAAASRELAAECPEGSEVKGEAPPGDGLQPSRADKVAESVSKAGSSQESEHSAGEVSTEQHDLKKVAGNSSTKADKRKKICIVCNKRFWSLQDLTRHMRSHTGERPYKCLTCERTFTLKHSLVRHQRIHQKGVKVTKRRHRGENDDDLSKGDDDSESEADQMGCDQLSDNESETVTSLSLSNDSPPPLSLAGSPLTATASQSPNQTGCKAVDPESNLHLPAAVNGVRQGTFLLQGNDQASLKSSEKVLADTAGPSDIIQNLLAIRSGSPMNHVLSSVESAPRLLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8L7</accession>
    <name>A0A401P8L7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Damage-specific DNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0005487</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001712">
        <property type="protein sequence ID" value="GCB69489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8L7"/>
    <dbReference type="STRING" id="75743.A0A401P8L7"/>
    <dbReference type="OMA" id="ITTRIDI"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000001">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000073">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002576">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002484">
        <property type="entry name" value="DNA damage-binding protein 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="15">
        <location>
            <begin position="14"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="16">
        <location>
            <begin position="396"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="14">
        <location>
            <begin position="790"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB69489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126928" checksum="C33CD7D08FB6C746" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P997</accession>
    <name>A0A401P997_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003225">
        <property type="protein sequence ID" value="GCB69688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P997"/>
    <dbReference type="STRING" id="75743.A0A401P997"/>
    <dbReference type="OrthoDB" id="8960715at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="338" mass="36666" checksum="1EC1A947248FE90C" modified="2019-05-08" version="1" fragment="single">MAHINWVNATWIGNLADGGSEEQSERRQTNIDSRQNRPGQGVSNTENDCAFEPDYAVPTLPASEGMQHIRIMEGMSRSLPSSPLLTHQSISVRLQPVKKITAPLRKAKFVESPRVPESELSSPTRTTAKKPDLDSFCPGDSEQELGPPPSVDEAANTLMTRLGFLLGDKASEVQTSTEFSMEEQDENQTSTETQRISPCSTLTSSTASPPANSPCSTLPPVSTSATAKDCSYGTVTSPTSTLESRDSGIIATLTSYSENVERTKYGGESSKESSSRTNVKPWHAQKSALDSCLYRVDENISGSTFSLNKFPERNLETVSSQSVHSIPLYLMPRPNSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9T0</accession>
    <name>A0A401P9T0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2723 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004633">
        <property type="protein sequence ID" value="GCB69879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9T0"/>
    <dbReference type="STRING" id="75743.A0A401P9T0"/>
    <dbReference type="OMA" id="HSVNLMC"/>
    <dbReference type="OrthoDB" id="197432at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052724">
        <property type="entry name" value="GT117_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021280">
        <property type="entry name" value="TMEM260-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16214">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16214:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11028">
        <property type="entry name" value="TMEM260-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="78519" checksum="AF174E669E15B761" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAE0</accession>
    <name>A0A401PAE0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab9 effector protein with kelch motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0012540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Rab9 effector required for endosome to trans-Golgi network (TGN) transport.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006078">
        <property type="protein sequence ID" value="GCB70034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAE0"/>
    <dbReference type="STRING" id="75743.A0A401PAE0"/>
    <dbReference type="OMA" id="SPRTCHY"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB70034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="392" mass="42923" checksum="D6F006B0815D98E1" modified="2019-05-08" version="1">MDHDNISQKVMEMLSALEPGESPQKATWYALVPRGENPDVRVGHTLTYIPDTSEKGKVIIVGGANPNGSFSDAHILNLDKHEWDIPEWKGLLPRYEHSSFVPVGRPGDLWLFGGADESANRNCVQVLNFETGVWRSPAVNGTPPTPRTCHGSAAAIGDCLYVFGGGDKGAEPVQDTQLHVFDKATLSWSQQSTEGKPPASRHGHVMVAIGSKLFIHGGLAGKFFFNDMYFIDTAAVNMKWKKVKIKGDIPGGCAAHSAFSHGKYIFIFGGMDATGALNTMYKYHIETNYWTRLEFDSSLPPGRLDHAMCVIPWKIREYESSSPASSNGLSAKGNTHKESKKQSGNDGNFTQQNCSVVQNQTKNIVNLCLIFGGMDTQGEVYNDCFVTLIDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAE5</accession>
    <name>A0A401PAE5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006093">
        <property type="protein sequence ID" value="GCB70147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAE5"/>
    <dbReference type="STRING" id="75743.A0A401PAE5"/>
    <dbReference type="OMA" id="RDWMYSV"/>
    <dbReference type="OrthoDB" id="5920068at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF2">
        <property type="entry name" value="ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="367" mass="41835" checksum="E0A7D824F090217A" modified="2019-05-08" version="1">MRSPAPRAEPAAAPTAPRAMISVRKPASSWPSGFRQLMFIPVISLSNCPDDQFWVTNNIGPGRGGRGMAMNRKEIQHGSWILMKGTIRFLFMVINNLVAIPSYVLYLIVLQPLKLLNSKLFWHVEGIMFKWLLAMVSSWGWTAGYTVVEWGDDVKAITEDETMVLVNHQATGDVCTLMMCLQDKGTVVCHMMWLMEYVFKFTNFGVVSLIHGDFFIRQGKAHRDQQLILLRQHLEKYYRSRDRKWIVLFPEGGFLRKRQETSQSFAKKNNLPFLKHVTLPRQGATEVILQTLCAQHENGAVGDANGAVEKQKGLQWVIDITIAYHKAKPIDIQTWIIGYREPTITHVHYRILLISLTGIVVNGQRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB36</accession>
    <name>A0A401PB36_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003301">
        <property type="protein sequence ID" value="GCB70330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB36"/>
    <dbReference type="STRING" id="75743.A0A401PB36"/>
    <dbReference type="OMA" id="FAPQNIT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000168">
        <property type="entry name" value="Elongation factor 1-alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB70330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="462" mass="50517" checksum="0A3AF31A05643F9F" modified="2019-05-08" version="1">MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWHGDNMLEASANMTWFKGWKINRKEGNANGVTLLEALDSILPPQRPTEKPLRLPLQDVYKIGGIGTVPVGRVETGILKPGMVVTFAPVNVTTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAANFTSQVIILNHPGQIAAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMIPGKPMCVESFSEYPPLGRFAVRDMRQTVAVGVIKAVERKATGAGKVTKSAQKAQKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB59</accession>
    <name>A0A401PB59_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spectrin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0005656</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001797">
        <property type="protein sequence ID" value="GCB70355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PB59"/>
    <dbReference type="OMA" id="RCAGRIC"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008091">
        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21316">
        <property type="entry name" value="CH_SPTBN1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000028">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000059">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000099">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000105">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000153">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000158">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="53"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="2126"/>
            <end position="2236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2020"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2238"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="922"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1353"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2056"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2107"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2238"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2270"/>
            <end position="2285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB70355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2292" mass="266441" checksum="D2376727937AAFEF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC39</accession>
    <name>A0A401PC39_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0005749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001836">
        <property type="protein sequence ID" value="GCB70690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC39"/>
    <dbReference type="STRING" id="75743.A0A401PC39"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04012">
        <property type="entry name" value="C2A_PI3K_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF29">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI3K-RBD" evidence="5">
        <location>
            <begin position="258"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="6">
        <location>
            <begin position="502"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="4">
        <location>
            <begin position="665"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB70690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="785" mass="86887" checksum="219DBC72FBBCA4AF" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD02</accession>
    <name>A0A401PD02_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitotic arrest deficient 1 like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0001431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000320">
        <property type="protein sequence ID" value="GCB70995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD02"/>
    <dbReference type="STRING" id="75743.A0A401PD02"/>
    <dbReference type="OMA" id="FGFIIEF"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000051">
        <property type="entry name" value="mitotic spindle assembly checkpoint protein MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="173"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="476"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="581"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB70995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="81798" checksum="99C0A5775F5A4317" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDC8</accession>
    <name>A0A401PDC8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor Sp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0005848</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001886">
        <property type="protein sequence ID" value="GCB71123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDC8"/>
    <dbReference type="STRING" id="75743.A0A401PDC8"/>
    <dbReference type="OMA" id="HRPVPIK"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22540">
        <property type="entry name" value="SP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000421">
        <property type="entry name" value="Sp2 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000455">
        <property type="entry name" value="Transcription factor Sp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="579"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="609"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB71123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="668" mass="71132" checksum="CDD39B137B3483FA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDX9</accession>
    <name>A0A401PDX9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0010981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004856">
        <property type="protein sequence ID" value="GCB71334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDX9"/>
    <dbReference type="STRING" id="75743.A0A401PDX9"/>
    <dbReference type="OMA" id="VPSPENM"/>
    <dbReference type="OrthoDB" id="9890439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015152">
        <property type="entry name" value="Growth/epo_recpt_lig-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF28">
        <property type="entry name" value="ERYTHROPOIETIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09067">
        <property type="entry name" value="EpoR_lig-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019019562" description="Fibronectin type-III domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB71334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="565" mass="63670" checksum="75C23B3FFDD86E2B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE85</accession>
    <name>A0A401PE85_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0001572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000358">
        <property type="protein sequence ID" value="GCB71434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE85"/>
    <dbReference type="STRING" id="75743.A0A401PE85"/>
    <dbReference type="OrthoDB" id="9947088at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000357">
        <property type="entry name" value="Fc receptor like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB71434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="279" mass="30780" checksum="EA0C8A871FC09702" modified="2019-05-08" version="1">MTKRQVIVKVPVSEPTLKSTRTGDNAVEGDTLDLSCAVLKGSYPITYKFYKVTTDGALYQKTLNATKAVYSITSVNSEHHGTYSCEASNTVNQRNQTKRSQYVTITVKDTTWWIYISSVSPVIILVAAAVILSLCLKRLRSNKDISQADESDGTHQGEPLQHIQGAYTDRNHEGDYTNIMPPEGNGADTERNHEGDYTYIMLPEENGSDSESDCDRDYTNVSSKRKAANIDSDSCSDENDAIQYTQIDLTALQSGNMPQPQGHTVYASIAFDKIQQGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG88</accession>
    <name>A0A401PG88_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0006184</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-cysteinyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13682"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002038">
        <property type="protein sequence ID" value="GCB72146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG88"/>
    <dbReference type="STRING" id="75743.A0A401PG88"/>
    <dbReference type="OMA" id="CLMFQAG"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051718">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20155">
        <property type="entry name" value="PWWP_DNMT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000008">
        <property type="entry name" value="DNA (Cytosine-5)-methyltransferase 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000006">
        <property type="entry name" value="DNA (Cytosine-5)-methyltransferase 3B isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000011">
        <property type="entry name" value="DNA methyltransferase 3 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.50">
        <property type="entry name" value="PWWP, helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054724">
        <property type="entry name" value="DNM3A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040552">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049554">
        <property type="entry name" value="DNMT3_ADD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF9">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17980">
        <property type="entry name" value="ADD_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22855">
        <property type="entry name" value="DNM3A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21255">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="16">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="443"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB72146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="873" mass="98956" checksum="1E0D1A14F3410FA4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGC3</accession>
    <name>A0A401PGC3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003600">
        <property type="protein sequence ID" value="GCB72182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGC3"/>
    <dbReference type="OrthoDB" id="10357060at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="17200" checksum="9F76D4A573798FE6" modified="2019-05-08" version="1">MLPNNNRPEFHFYTSPLDGPPNYYFWYSPYWQIQNIPLSPPISTKQSPESPNPARESEPAHLETPALQHVQLCSYLAHTQYDKALYDIFFHIPDPYISKKELLSVPDEDAEFWGTLHFTGINAAQELLSKRRFEKICSEILIETKTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGF2</accession>
    <name>A0A401PGF2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002051">
        <property type="protein sequence ID" value="GCB72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGF2"/>
    <dbReference type="STRING" id="75743.A0A401PGF2"/>
    <dbReference type="OMA" id="LIWIVIW"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF67">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="304" mass="33997" checksum="260B41AAFBE42CBD" modified="2019-05-08" version="1" fragment="single">MSERQTNINSLFLNEDSAKRSPADNRVQRFQKAVRKRAGRAKKSLSSISRQSVQSFFKKNAFVLLTIFAVILGIILGFTLRRYKLSYREIKYFSFPGELLMRMLQMLVLPLIVSSLVSGMAALDSKASGKMGIRAVVFYMVTTVIAVFIGIVMVMIIHPGKGSKVDLHREGKIEQVQAADAFMDLIRNMFPPNLVEACFKQYKTNYDTRKVMITTSSPINLTTSTEPSMMDNITEAFKKLQELMLDEEVIPIAGSANAVNALGLVVFSIAFGLVIGNMKQKGRALKEFFDCLNEAIMRLVAIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHE1</accession>
    <name>A0A401PHE1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Voltage-gated calcium channel subunit alpha Cav2.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0002056</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000492">
        <property type="protein sequence ID" value="GCB72552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHE1"/>
    <dbReference type="STRING" id="75743.A0A401PHE1"/>
    <dbReference type="OMA" id="INTSEQM"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000015">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF6">
        <property type="entry name" value="VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14 18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="21">
        <location>
            <begin position="53"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="18">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB72552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="332" mass="37380" checksum="E57BAD96199259D8" modified="2019-05-08" version="1">MYGSKSMAQRARTMALYNPIPVRQNCFTVNRSLFIFSEDNIIRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHHTCFNKETNQQVTDFPCGSRECPNGTECGGYWTGPSYGITNFDNILFAVLTVFQCITMEGWTDILYNANDALGNAWNWLYFIPLIIIGSFFMLNLVLGVLSGNTKEEFSKGAGIIVLLQNGYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK91</accession>
    <name>A0A401PK91_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000670">
        <property type="protein sequence ID" value="GCB73542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK91"/>
    <dbReference type="STRING" id="75743.A0A401PK91"/>
    <dbReference type="OMA" id="LLWAQEI"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="315" mass="36130" checksum="298E7D09F3D659C7" modified="2019-05-08" version="1">MQWLGSPTTRATKNTGTIGQGRIRPGRRTPPVGKPPIGSPVRGGRGKVRLSRAAPSSPPFALKDRERSCFAAPGTNKILPHFLRCFRMSYTEKPDEITKDEWMEKLNNLHIQRADMNRLIMNYLVTEGFKEAAEKFRVESGIEPSVDLDTLDERIKIREVILNGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDNPEDSPFGDLLNMMQRQKVWSEVNQAILDYENRESTPKLAKLLKLLLWAQNELDHKKVKYPKMTDLSKGAIEEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKE1</accession>
    <name>A0A401PKE1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000681">
        <property type="protein sequence ID" value="GCB73590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKE1"/>
    <dbReference type="STRING" id="75743.A0A401PKE1"/>
    <dbReference type="OMA" id="FQPVQMG"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13766">
        <property type="entry name" value="TGF_beta_GDF5_6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF160">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019540045" description="TGF-beta family profile domain-containing protein" evidence="10">
        <location>
            <begin position="27"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="11">
        <location>
            <begin position="281"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB73590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="404" mass="45701" checksum="B0B11D03BE3837AB" modified="2019-05-08" version="1">MDIPKAAALVWCALCCCWEFLSVLEAAALGSRQDSPPRDAVSSSSLDRKHERTFRHRRAGPVVPHEYMLSLYRILSERERTGLNSSLTRAPTRANMVTSFVEQGHDGTSVGKRQRYLFDVSKLPTSEELVGGELRISRHFAVNLQAALSEGGSLYRTELYSCQGLGEYPPKRMDSRTVDILDADSSHWQVFDVWDLLKSHITATLLCLDLEVISDYSQEALDPRLLGFNRSDQPEEKALLVVFSNTRKRENLFREIRDKIKSLGGSDSLQPSNEPNVKRRRKRRTAFSSRPSRGSGKKGRSRCSRKPLHVNFKELGWDDWIIAPLDYEAYHCEGICDFPLRSHLEPTNHAIIQTLMNSMDPESTPPSCCVPSKLSPISILYIDSGNNVVYKQYEDMVVESCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKG3</accession>
    <name>A0A401PKG3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000690">
        <property type="protein sequence ID" value="GCB73612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKG3"/>
    <dbReference type="STRING" id="75743.A0A401PKG3"/>
    <dbReference type="OMA" id="MTWFRDG"/>
    <dbReference type="OrthoDB" id="8923679at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000359">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="248" mass="27830" checksum="D2D6A91D7C1B69D1" modified="2019-05-08" version="1">MYDACWVLCMYVFNIKVSNPEQYRCLANDVPPYFKTEPGPPQIHLEGNRLVLTCLAEGSWPLEFKWLRNDTTITAFSSEYRYVIPSLQRSDTGFYQCVVRNRRGALLQRKTQVQVAYMRSFEGGDQQIIVLQGQAAVLKSPDISSYPQPQMTWFRDGQKIIPSNRIAVTLDNHLVVLSATAADEGNYYVQAVNEKNGENKTSPFIYLKIANADEKADPVAPTIVVPPKNTSIVAGTSEVTLECIANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKY3</accession>
    <name>A0A401PKY3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="18">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0002876</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="18"/>
    <dbReference type="EMBL" id="BFAA01000745">
        <property type="protein sequence ID" value="GCB73794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKY3"/>
    <dbReference type="STRING" id="75743.A0A401PKY3"/>
    <dbReference type="OMA" id="DTCVWAY"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000002">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF40">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB73794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="653" mass="74144" checksum="764191B6680CDA06" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLG0</accession>
    <name>A0A401PLG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CXC MSL2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0003043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MSL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000799">
        <property type="protein sequence ID" value="GCB73960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLG0"/>
    <dbReference type="STRING" id="75743.A0A401PLG0"/>
    <dbReference type="OMA" id="GMYQEIP"/>
    <dbReference type="OrthoDB" id="10012174at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13122">
        <property type="entry name" value="MSL2_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037922">
        <property type="entry name" value="MSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032049">
        <property type="entry name" value="Msl2-CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032043">
        <property type="entry name" value="Msl2_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048">
        <property type="entry name" value="MSL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16682">
        <property type="entry name" value="MSL2-CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16685">
        <property type="entry name" value="zf-RING_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52051">
        <property type="entry name" value="CXC_MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CXC MSL2-type" evidence="3">
        <location>
            <begin position="393"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="516" mass="55241" checksum="5F27F0E29F0E5235" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLX1</accession>
    <name>A0A401PLX1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0003223</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01000865">
        <property type="protein sequence ID" value="GCB74136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PLX1"/>
    <dbReference type="OMA" id="EVVQTWY"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1010:FF:000002">
        <property type="entry name" value="Transient receptor potential cation channel subfamily M member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF15">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="25">
        <location>
            <begin position="1455"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB74136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1665" mass="191432" checksum="648EC511EEC16C8D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNA0</accession>
    <name>A0A401PNA0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001041">
        <property type="protein sequence ID" value="GCB74624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNA0"/>
    <dbReference type="STRING" id="75743.A0A401PNA0"/>
    <dbReference type="OMA" id="HERVAMK"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF5">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 74B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113865" checksum="8CD67E0A9D8C2CBD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNC8</accession>
    <name>A0A401PNC8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Syntabulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0003672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001025">
        <property type="protein sequence ID" value="GCB74581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNC8"/>
    <dbReference type="STRING" id="75743.A0A401PNC8"/>
    <dbReference type="OMA" id="MEEWHAP"/>
    <dbReference type="OrthoDB" id="5807119at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019896">
        <property type="term" value="P:axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060074">
        <property type="term" value="P:synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028197">
        <property type="entry name" value="Syntaphilin/Syntabulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16208">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN/SYNTAPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16208:SF4">
        <property type="entry name" value="SYNTABULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15290">
        <property type="entry name" value="Syntaphilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB74581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="69819" checksum="6DA1C0708DE7731C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP28</accession>
    <name>A0A401PP28_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001101">
        <property type="protein sequence ID" value="GCB74801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP28"/>
    <dbReference type="STRING" id="75743.A0A401PP28"/>
    <dbReference type="OMA" id="REHNMIS"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF33">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="197"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="399" mass="44826" checksum="44AF7BC7A5E9DF1B" modified="2019-05-08" version="1">MEVFGCPYWADVINFDGYSPLSYMFRNKKMKTLKDIISLKFKTSENEGVIFHGEGQQGDYVTLEIKKAKLVLRVNLGSNQHSSINGDTSVTTGSLLDDHHWHSVIIERYGRNINFTLDRETQHFRTNGEFDHLDLDYELSFGGMPFSGKPSFNGKNFKGCMESINYNGINITDLARRGKLDTSKVGNLSFSCMESRAVPVFFNSSSYLLLPGHMNQDLFSVNFMFRTWNPNSLLLLSRFAPGYGMVEIDLSDGKVSISISVNQTKMNSIEMSAGFGLNDGQWHIIQFHAKENSAILTIDGDDASAVRTNSSMQIKTGDQYFFGGLALFECGNNSASLAYLTPQRNKSLANSAASRAVERNPENLHNSQQKRQKKRAECINPAWSSLDVEWCHLNFEVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ03</accession>
    <name>A0A401PQ03_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydantoinase B/oxoprolinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014995">
        <property type="protein sequence ID" value="GCB75200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ03"/>
    <dbReference type="STRING" id="75743.A0A401PQ03"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="368" mass="39891" checksum="6C6479C3C31FDF76" modified="2019-05-08" version="1" fragment="single">TILIEPDCTADITQHGDIKITIGSGKAHAIGPKLDTIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPAGGLVSNAPHIPVHLGAMQETVQFQINHLGDDLKEGDVILSNHPSAGGSHLPDLTVITPVFRKGVSRAVFFVASRGHHADIGGITPGSMPPHSKSLQEEGAVFISFKLVKDGVFQEEAVTEALLAPAQIPGSSGTRNLHDNLSDLRAQVAANQRGIQLVNELIDVYGLEVVQAYMFHIQNNAEIAVKEMLREFARRCRRQVAGLLEVESEDHMDDGTPIRLKVKINEAEGTAVFDFTGTGPEVFGNCNAPRAITLSALIYCLRCMVGQDIPLNQVGTTGHDWGNECLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQR2</accession>
    <name>A0A401PQR2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0016425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009911">
        <property type="protein sequence ID" value="GCB75453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQR2"/>
    <dbReference type="STRING" id="75743.A0A401PQR2"/>
    <dbReference type="OMA" id="FKAECSI"/>
    <dbReference type="OrthoDB" id="10251692at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000031">
        <property type="entry name" value="Ankyrin repeat, family A (RFXANK-like), 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF3">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB75453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="313" mass="34103" checksum="3209715747EC18BC" modified="2019-05-08" version="1">MAEVGNPATDAEPSGGENGNHSSFAEIPYIKVEPHADIHTEGGPSHNVAMGMKFVLPSRFDMNVCSRFVKSLNEEESKNIQDQVNSDLEVASVLFKAECNIHTSASPGIQVRHVYTPSVTKHFSPIKQSTTLTNKHRGNEISAAPLLLHSLSVHQLAAQGELIHLASRIEQDNLLNMQDEQGFTPLMWAAAHGQIAVVEFLLQNGGDPHRLANGRESALSLASSKGYSNIVNMLLDYGCDVNEYDWNGGTPLLYAVHGNHVKCVETLLEYGADPTVETDSGFNAMDMAVGLGFKNVQQVIEAHLLKLLLKIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRF2</accession>
    <name>A0A401PRF2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015118">
        <property type="protein sequence ID" value="GCB75709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRF2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="96" mass="10783" checksum="B80FA8A175094034" modified="2019-05-08" version="1" fragment="single">DSIASTPQDPISSLVAIINITTSPGTRKEPDIAEVKSSDRMCTNVTRSITFGRHELTPYRDVSIMDADDLERTDNDQRIHRYVQKGLPCIPRLRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRK3</accession>
    <name>A0A401PRK3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0020393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016424">
        <property type="protein sequence ID" value="GCB75759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRK3"/>
    <dbReference type="STRING" id="75743.A0A401PRK3"/>
    <dbReference type="OMA" id="KPVRGIC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="57"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB75759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38866" checksum="14D3AEDE44B6C3ED" modified="2019-05-08" version="1" fragment="single">ICSNMPVPCSGCDKKAAALRRPKTGHSLCKECFFWAFEEEVHQTILSAKLFQQGETVGIGASGGKDSTVLAHVLKVLNERYDYRLNLMLISVDEGITGYRDDSLETVKRNQQQYDLPLKIVSYEELYGWTMDQIVKKVGLKNNCTFCGVFRRQALDRGAMMLKVDKVCTGHNADDIAETVLMNFLRGDIARLRRCTSIITGSEGAIPRCKPLKYAYEKEIVLYAYFKKLDYFSTECVYSPNAYRGYARAFLKDLESIRTSAIMDVIHSGENLSIKEDVKMPTQGTCTRCGYISSQKLCKACALLEGLNRGLPKLGIGKHHKLHNRLLNKEPLTEDEEKKLGAINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTX4</accession>
    <name>A0A401PTX4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013976">
        <property type="protein sequence ID" value="GCB76523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTX4"/>
    <dbReference type="STRING" id="75743.A0A401PTX4"/>
    <dbReference type="OMA" id="FEDYPWR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097527">
        <property type="term" value="P:necroptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="196" mass="22489" checksum="5A3073994C3C4C11" modified="2019-05-08" version="1">MEYLELGSLRTVLQGKRQLSWQTCVRMALDAASGLYRMHQSIEKFKLHCSIDSTRFLVDQGLRVKLGDLELAKTETSIRRTSATSQGSKKMPFISPQQLGNINYPYDKPCEVYSFGIVLWEIASRILPFRGFTDEEIHRKVCEKMQEPLPSDCPNDLRELIDECRAYDPFERPKAGAIVDRLKNILNRISTVTNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU46</accession>
    <name>A0A401PU46_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0016594</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010116">
        <property type="protein sequence ID" value="GCB76669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU46"/>
    <dbReference type="STRING" id="75743.A0A401PU46"/>
    <dbReference type="OMA" id="LWRMRHK"/>
    <dbReference type="OrthoDB" id="6088892at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004875">
        <property type="term" value="F:complement receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000034">
        <property type="entry name" value="G-protein coupled receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002234">
        <property type="entry name" value="Anphylx_rcpt_C3a/C5a1-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000826">
        <property type="entry name" value="Formyl_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225">
        <property type="entry name" value="CHEMOTACTIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF24">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01104">
        <property type="entry name" value="ANPHYLATOXNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="28"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB76669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="352" mass="39580" checksum="F46B3380AB354F97" modified="2019-05-08" version="1">MTTDRVSVATHTFTIVVSLVTFFLGVPGNGLVIWVTAFKMKRTVNTVWFQGLALADFVFSLLLPFTVALTILDFHWPFGTAFCKINSGVAVLTMFSSVLTLTAISLDRCISVVLPVWSQNHRRPRLAALISLALWGAAFLLSIPTFFYRDTMKYRDITRCYTNFLTSAEGDALNSITGEDYKAMLKKLISIKDSRFKSLAIVRFVFGFLLPFLIIGASYTIIGLRLWRDRLAPSWKPFKVMIAIILAFLLCWAPHHTFIFLRLWHPPSPHLVLALRVGNPLSSSLASFNSCLNPILYICMGHNFREKVKRSCGAFLRKVLENAFVEDSMHFSATSRAKTKSMTLGDDNSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUR1</accession>
    <name>A0A401PUR1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GAE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0021044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017974">
        <property type="protein sequence ID" value="GCB76880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUR1"/>
    <dbReference type="STRING" id="75743.A0A401PUR1"/>
    <dbReference type="OMA" id="MRIKIMY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="8">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="17633" checksum="5F6583F54F9C6FD3" modified="2019-05-08" version="1">MAPELAPSFSGTMPLNVQAPQISQAPFLLDGLASQGVFNDLASGVPPVTAYCKGGLKIEFNFERSNTNPNVTVVTISATNSTEGDMTDFVFQAAVPKTFQLQLLSPSNNIIPARNAGAVTQVIKVLNPQKQQLRMRIKIMYNLNGSPVQDLAEVNNFPPQSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVL1</accession>
    <name>A0A401PVL1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0020541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016733">
        <property type="protein sequence ID" value="GCB77103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVL1"/>
    <dbReference type="STRING" id="75743.A0A401PVL1"/>
    <dbReference type="OMA" id="SHYLAIC"/>
    <dbReference type="OrthoDB" id="10003563at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB77103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="145" mass="16061" checksum="61953927BA61327E" modified="2019-05-08" version="1">MNQIETRLIDFRRLSHLAEREESLVGALGVRFSGKVIDCKAIMTSSDVNLLPALVPQDDQSSKLLRKSKESPFVPIGIAGFASVVAYGLYRLKTRGNSKMSVHLIHMRVAAQGCVVGAMTIGVLYSMYKEYVVKPRELKNAVLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW05</accession>
    <name>A0A401PW05_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0017585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011549">
        <property type="protein sequence ID" value="GCB77311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW05"/>
    <dbReference type="STRING" id="75743.A0A401PW05"/>
    <dbReference type="OMA" id="CYLPIVF"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000016">
        <property type="entry name" value="Derlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB77311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="255" mass="28993" checksum="95C41E387620AF82" modified="2019-05-08" version="1" fragment="single">IGCRGCQSGGGGEAMAAYQSLLQEYRRMPTVTRAYTTACVLTTAAVQLEFITPFQLYFNPDLIVKKYQVWRLLTNFLFFGPLGFSFLFNMIFLYRYCRMLEEGSFRGRTADFLLMFIFGGFLMTLFGIFASLFFLGQAFTIMLVYIWSRRNPFVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSVIVDLLGIAVGHIYYFLEDVFPNQPGGVKLLVTPGFLKAIFDVAEEDPNYNVLPEDQPGGFNWGQGQRLGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW52</accession>
    <name>A0A401PW52_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B-cell scaffold protein with ankyrin repeats</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0019273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with LYN, ITPR1 and ITPR2.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014167">
        <property type="protein sequence ID" value="GCB77360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW52"/>
    <dbReference type="STRING" id="75743.A0A401PW52"/>
    <dbReference type="OrthoDB" id="8192811at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050869">
        <property type="term" value="P:negative regulation of B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000017">
        <property type="entry name" value="B cell scaffold protein with ankyrin repeats 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052446">
        <property type="entry name" value="B-cell_PI3K-Signaling_Adptrs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041340">
        <property type="entry name" value="PIK3AP1_TIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267:SF13">
        <property type="entry name" value="B-CELL SCAFFOLD PROTEIN WITH ANKYRIN REPEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267">
        <property type="entry name" value="BANK1/PIK3AP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18567">
        <property type="entry name" value="TIR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIK3AP1 Toll/interleukin-1 receptor" evidence="7">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB77360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="20208" checksum="9C6E0E98A52C6064" modified="2019-05-08" version="1">MPCPVDTSSPDLLILYEEDAEEWSTYLKQIFSEALNPQSICSYDVGCPNDLKVTAADLLAYKCKLLVLTPGFLASLTTSKRIQLGKILQAPDEVVVLLCGVPSSDDLYKLVHAERGCWELSSDQDAQEYLSVVSCIINSGEATKFLNLDVLSLEVRDVFPMVMQAASIVIDAYFRTLKKTSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWQ0</accession>
    <name>A0A401PWQ0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016843">
        <property type="protein sequence ID" value="GCB77557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWQ0"/>
    <dbReference type="STRING" id="75743.A0A401PWQ0"/>
    <dbReference type="OMA" id="DAEQHFR"/>
    <dbReference type="OrthoDB" id="7414155at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049502">
        <property type="entry name" value="SBSN_GxHH_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21009">
        <property type="entry name" value="SBSN_GxHH_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="442" mass="44815" checksum="012789B69FB6DEE5" modified="2019-05-08" version="1">MGVDATAWGLGVDTTAQGQGVDTTPRGLGVDTAFRGLGEDNTARGPGVDTTSRGQGVDTTSRGQGVETTSRGLGVETTSRGLGVDTTSRGQGVETTSRGLGVETTSRDLGVDTAFRGLGEDTTALRLGVDTTSRGQGVETTSRGQGVDTTSRGQGVETTSRGLGMETTSRDLGVDTAFRGLGEDTTALRLEVDTTSRGQGVDTTSRGQGVETTSRGQGVETTSRGLGVDTTSRDLGMDTAFRGLGEDTTALRLGVDRTAKGLGVDTTAHGLGVDTISRGQGVDSTARGLVVDPTARGLGVDTTSRDLGVDTAFRGLGEETTAFSLGVDATARGLGMDTTAHGLGVDTISRALGVHTTARGLGLDTRARGLGVDTTARSLGVDTTSQGLGMDTTARSLGVDTTSRGLGVVKAFRGLGVDTTSRGLGVDTTSRGLGVDRAFRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXD0</accession>
    <name>A0A401PXD0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multicilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Multiciliate differentiation and DNA synthesis-associated cell cycle protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein Idas</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0019321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the geminin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014260">
        <property type="protein sequence ID" value="GCB77772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXD0"/>
    <dbReference type="STRING" id="75743.A0A401PXD0"/>
    <dbReference type="OMA" id="ATIAWED"/>
    <dbReference type="OrthoDB" id="9445365at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22590">
        <property type="entry name" value="McIdas_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1180">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022786">
        <property type="entry name" value="Geminin/Multicilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372">
        <property type="entry name" value="GEMININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372:SF3">
        <property type="entry name" value="MULTICILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07412">
        <property type="entry name" value="Geminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111469">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB77772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="367" mass="41400" checksum="6AE6CA25C7287185" modified="2019-05-08" version="1">MVELPIRTSGKKQPRVDRKKDHQKVNGTNSQVTIYSQAATNTPDSAFVTIDETVWQDLADCTSSLHQESSNEPAPQNQPLEGASEFDLQDFKDVGMMMCDPTSLMQPMSMTDAELPLSDYVSDLEACISSSISGVHDSLMEMNLQTDNSQTPEQFWKDVAEENQKALGDALEENEHLQVTLKRKQYEIVSLKERNVQLKELASKAKRLASILDKLMKQECQNGSDTMSEIFPSKASAKRQRVEGTYFDNQDCDKVDEILRDISEKCNVALHTLNDKDSKHFRGYHYSEETSYNESQEAINMYGCFNGLQTSMSCNLASLDTSELDNDMSFRTSIRDHCTIRTLAFPQGNAFTTRTPSGGFKFRWIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXY5</accession>
    <name>A0A401PXY5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0018531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012997">
        <property type="protein sequence ID" value="GCB77903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXY5"/>
    <dbReference type="STRING" id="75743.A0A401PXY5"/>
    <dbReference type="OMA" id="NIQSIRW"/>
    <dbReference type="OrthoDB" id="6353782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF59">
        <property type="entry name" value="HEPATIC AND GLIAL CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019569675" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="34"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB77903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="275" mass="30612" checksum="93E8E2B85F7DAEF9" modified="2019-05-08" version="1" fragment="single">LPLVVMRFRVFAQMTIFILFFLHLSQLQPGSFSAQVTRNSWVAATGSSILLPGTDKEFANLHWEFSNPSRTLPILDCGKDYQEIYDQYKTRVELNKSDGSLLLKDLHEADSGKYKITVDLDPSRTRILTLTVLDPLSIPHISGNGSLESHTITLICVVQSGIANSVRWTRGGLALPDDERYWLSEGNSTLTISNAQESDTGYYTCTFSNLVSQSNNSYQLTVKGHEIRTHLGLILPFGLCASVFLLVLRYGKPCRPKDLDPYLLTAVGAMALYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY61</accession>
    <name>A0A401PY61_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neural cell adhesion molecule 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0018538</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013015">
        <property type="protein sequence ID" value="GCB77983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY61"/>
    <dbReference type="STRING" id="75743.A0A401PY61"/>
    <dbReference type="OMA" id="PNITWHF"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000086">
        <property type="entry name" value="Neural cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000173">
        <property type="entry name" value="Neural cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009138">
        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="96"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="190"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="288"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB77983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42874" checksum="643256C843BF4C00" modified="2019-05-08" version="1" fragment="single">RAKLRIEPPTGNIDLNEDKVFICKVEGEAEELRWFDKLGEEIYPDASDRFSLESSEYDLQLLIRNAQVDDNGVYKCTAEAENGDEIERSISIKVIQRVTFDNVISNLEFDESDVATLDCIVTGIPEPTVSWTRDGQDVTRQDRFQKLENNSLVIRNIQPSDAGIYFCVGRIAARNEQESKSIAVKVNYAPRLISPAPEVVFTWLGNPVNVLCSVESFPQATFNWSHRGRELGESANVSIVANGDVSVSVVEVTVDSEADLGEYICNASNRLREVSRSIWVKEGGFPSAPQNLTVEPHSTTAQVSLGKPASDGGIPILGYKLEWKSDGAEWSSKMTESETFQIVELEPFTLYQFRAAARNGKGLGEYSKNVTAKTLSIREYTVSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZB2</accession>
    <name>A0A401PZB2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0017742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011786">
        <property type="protein sequence ID" value="GCB78461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZB2"/>
    <dbReference type="STRING" id="75743.A0A401PZB2"/>
    <dbReference type="OMA" id="SQKWDSA"/>
    <dbReference type="OrthoDB" id="29657at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF12">
        <property type="entry name" value="PROTEIN GPR107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019520868" description="GOST seven transmembrane domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="266"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB78461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="476" mass="53541" checksum="E9BD7F9F3D0D09F1" modified="2019-05-08" version="1">MAALSLSPLWGWSFLLCALFSTSVRGRIHRLILKDDVRQKIHLNTFGFFKNGNMTVEMTSLISKGFDFKTVENSALGLSLDRSKNDGFSSYLEEDIDFCFLKKKPPSDVPVTLFVFDFGKQQVRVQTTGKNQPKVTDVGTEGSQPTKDKSSKASVKPQSESEKVAGLLKKNETVKQFEEAQKAKPKPVTRAAEPKAQTIPLKEKNASYSFTFSLTINADEEQGLYSLYFHNCYTDKKPSLKSFQFDMDITIVEQNPGSYLSAGEIPLPKLYISMAFFFFLAGVVWVYILRKRSNDVFKIHWLMGALAFTKSLSLVFHAIDYHFISTQGYPIEGWAVVYYITHLLKGALLFITIALIGTGWAFVKHILSDKDKKIFMIVIPLQVLANVAYIIIESTEEGTTEYGLWKEILFLVDLLCCGAILFPVVWSIRHLQEMSALDGKGKEESRHRNGCYVGSLKQNTTSGYSQKWDSAGDTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZB4</accession>
    <name>A0A401PZB4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein S100</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S100 calcium-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0015834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the S-100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009170">
        <property type="protein sequence ID" value="GCB78456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZB4"/>
    <dbReference type="STRING" id="75743.A0A401PZB4"/>
    <dbReference type="OMA" id="ICIQCND"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00213">
        <property type="entry name" value="S-100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034325">
        <property type="entry name" value="S-100_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF134">
        <property type="entry name" value="PROTEIN S100-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB78456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="11692" checksum="0F9CD6023DE8D004" modified="2019-05-08" version="1">MCSKLTDLETCMQTMMAVFHKYACKDKDDKVFTLSNPELKELLSKELSGFVKGAADAEAVNKIMKKLDHDKDGEVNFQEFVVMVSSICIQCNDLLMAHIKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q139</accession>
    <name>A0A401Q139_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011901">
        <property type="protein sequence ID" value="GCB79013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q139"/>
    <dbReference type="STRING" id="75743.A0A401Q139"/>
    <dbReference type="OMA" id="ACKKNFT"/>
    <dbReference type="OrthoDB" id="1925875at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="7838" checksum="53CFF367E1EBCB9F" modified="2019-05-08" version="1" fragment="single">MALTKGFRVFEKQKPGCCSVLLESRNRQDCLLFQAGAVAILSTEEKETVKSHYVKIMDAYGCLGVLRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q150</accession>
    <name>A0A401Q150_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011930">
        <property type="protein sequence ID" value="GCB79127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q150"/>
    <dbReference type="STRING" id="75743.A0A401Q150"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03067">
        <property type="entry name" value="PDI_b_PDIR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000105">
        <property type="entry name" value="protein disulfide-isomerase A5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041865">
        <property type="entry name" value="PDI_b_PDIR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018967649" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18954" checksum="25A60C91078111A5" modified="2019-05-08" version="1">MAPRRQSGALGAAGTLQTICFLWLAVLSTCLMAAKVSPLIEKVDDHKELKKLTRTRNNVLVLYSKSAATAERPLKLLSDVAEAVKGQGTIAWVDCGNSESRKLCKKMKVEPASKKNGVELLHYKDGAFHVEYERPETFKSMVAFMRDPEGAPLWEENPEAKDVVHIDSEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q248</accession>
    <name>A0A401Q248_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016000">
        <property type="protein sequence ID" value="GCB79403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q248"/>
    <dbReference type="STRING" id="75743.A0A401Q248"/>
    <dbReference type="OMA" id="CESCTEA"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000019">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="14421" checksum="DAFD285CB428DDA4" modified="2019-05-08" version="1">MAEECITVGGVMDVNTALQEVLKTTYIHDGLCCGLREAVKVLDKRQAHLCVLAGNCDEAQYVKLVEALCAEHQINLITVDDNKKLGEWVGLCKIDREGKLCKAVGCNCVVVKDYGKDSQAKDVIDNYFRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4G2</accession>
    <name>A0A401Q4G2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0017121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010861">
        <property type="protein sequence ID" value="GCB80260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4G2"/>
    <dbReference type="STRING" id="75743.A0A401Q4G2"/>
    <dbReference type="OMA" id="TTWGFMV"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="143"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB80260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="302" mass="35848" checksum="AC695E6F643CE266" modified="2019-05-08" version="1">MYSIGSSRVFDPYVQVIQNANITQYIWDKSLLQPLWDYLRSNHQDALRSPLFPVVISVSTYFALCTFYMVLDLLAPRCPLVRRYKIHPEQHVTWEDIFKTLWHTGYNHLIFVFPAAAGQWYWRPPIPLQQEAPLVSEFLIGILGCTILFDFQYYFWHMMHHKVRWLYTTFHAIHHEYYAPFSWSTQYLSAWELVSVGFWTTLDPIILQCHCLTGFTFMVFNIWISVDDHSGYDFPWALHNLVPFGLWGGTVKHDAHHQKPQSHFAPFFAHWDWLCGTYCECKRSPAVQELRMKSRKASEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5C2</accession>
    <name>A0A401Q5C2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STIM1/2 Orai1-activating region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009706">
        <property type="protein sequence ID" value="GCB80558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5C2"/>
    <dbReference type="STRING" id="75743.A0A401Q5C2"/>
    <dbReference type="OMA" id="APIRPRH"/>
    <dbReference type="OrthoDB" id="9986177at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11722">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3550:FF:000001">
        <property type="entry name" value="Stromal interaction molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000011">
        <property type="entry name" value="Stromal interaction molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032393">
        <property type="entry name" value="SOAR_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF2">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16533">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STIM1/2 Orai1-activating region" evidence="3">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB80558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="550" mass="62164" checksum="C8850824EE554CB2" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5I6</accession>
    <name>A0A401Q5I6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0016284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009755">
        <property type="protein sequence ID" value="GCB80625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5I6"/>
    <dbReference type="STRING" id="75743.A0A401Q5I6"/>
    <dbReference type="OMA" id="HEACIFL"/>
    <dbReference type="OrthoDB" id="8574072at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042979">
        <property type="entry name" value="VWC2/VWC2L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059152">
        <property type="entry name" value="VWC2L_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46252">
        <property type="entry name" value="BRORIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46252:SF2">
        <property type="entry name" value="VON WILLEBRAND FACTOR C DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23333">
        <property type="entry name" value="VWC2L_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019289089" description="VWFC domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="7">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB80625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="178" mass="19612" checksum="4A0C9EEE08C07319" modified="2019-05-08" version="1">MAPGLAAECVLLLLLSPVLLSPAAAHQEDELEVDNTLGPANNDMDFDDYRGKGCVDDSGFVYKLGERFFPGHSNCPCVCTEDGPVCEQPECPQIHPKCSKVEHNGCCPECKEVKNFCEYRAKTYKVLEEFKPSPCEWCRCEASSEVHCVVADCAVPECVNPVYEPEQCCPVCKNGKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q694</accession>
    <name>A0A401Q694_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0022091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021155">
        <property type="protein sequence ID" value="GCB80881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q694"/>
    <dbReference type="STRING" id="75743.A0A401Q694"/>
    <dbReference type="OrthoDB" id="2135133at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="4">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB80881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="18880" checksum="1E2A055061304D03" modified="2019-05-08" version="1" fragment="single">MDEVLEGKLDREFQMQAERLRNYVLNSELESTMGGHKVNGQMLARMVETCVSSMCKGQRIILENLRDIVLCEKPTVELDKVTAVKGVKTASQTKMERIVPLTKPSAGSAMYDMQEPMCLIENSASGELRVNQEAVNILSEISQPVVVVAVVGLYRTGKSYLMNKLAGKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6K2</accession>
    <name>A0A401Q6K2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcium-activated chloride channel N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021230">
        <property type="protein sequence ID" value="GCB80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6K2"/>
    <dbReference type="STRING" id="75743.A0A401Q6K2"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcium-activated chloride channel N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10351" checksum="33DD37746DD40AA3" modified="2019-05-08" version="1" fragment="single">MCAEADVIIAEPYLKYGDEPYTQQYGGCGEKGQYIHFTPNFIRNSSLTQIYGPKEKVFVHEWAHLQWGVFDEYNQLVPYYLSNGKYEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6T2</accession>
    <name>A0A401Q6T2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022578">
        <property type="protein sequence ID" value="GCB81080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6T2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10473" checksum="114FF6E4AEA6DE40" modified="2019-05-08" version="1" fragment="single">WCSRALPAFITVLAVLVLLLILLHIWICKGGRSGKWDNKRQNEIFSLSETTQRQGRKERQTGELHETQTQRLHEGALRVSAINMLSSCPDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q765</accession>
    <name>A0A401Q765_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018761">
        <property type="protein sequence ID" value="GCB81210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q765"/>
    <dbReference type="STRING" id="75743.A0A401Q765"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="180" mass="20566" checksum="7845D6A1C52DD938" modified="2019-05-08" version="1" fragment="single">GALIATYVVSERQADIAGLIFIAPLVLMNPESATPMKIMFSKAVNHLLPNVPLGYINPRLTSRDEMQVNDYIRDPLNCHVPVRVRFAFEVLHALNNIERIFPNITVPMLILHGELDKFSDIRGSYIMFGKVASTDKTFKVFSNCYHELQNELPEVIAELLYLVDEWLEQRLPLLEATERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q892</accession>
    <name>A0A401Q892_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0022810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01024227">
        <property type="protein sequence ID" value="GCB81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q892"/>
    <dbReference type="STRING" id="75743.A0A401Q892"/>
    <dbReference type="OMA" id="QCELCAL"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000076">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF293">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="298" mass="34370" checksum="BA514A8D5EEAD731" modified="2019-05-08" version="1" fragment="single">VLLSHPIDDANMEGNTLKITDFGLAREWHKTTKMSTAGTYAWMAPEVIKTSTFSKGSDVWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPELFAQLMAECWDEDPHRRPQFASILEQLIAIEEQVLLEVPQESFHSMQEDWKLEIQEMFNELRAKEKELLCREEELKRAALQQKSHEESLRQREHALQQWERDVFERELSLLIYQMNEEKPNVKKRKGTFKKNKLKGIGGQRISNPIDFQHKLTVQASPQLNKKKGWLEIGTGSPTIISFVPRLRAIQCKRNLWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9X8</accession>
    <name>A0A401Q9X8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0022289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021967">
        <property type="protein sequence ID" value="GCB82170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9X8"/>
    <dbReference type="STRING" id="75743.A0A401Q9X8"/>
    <dbReference type="OMA" id="TARTIYH"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF20">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 2 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB82170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="24091" checksum="3F024915B81D815D" modified="2019-05-08" version="1" fragment="single">LLGVDKLLSYTLNEWLTDIRKNQLPGILGGVGPMHSFVQLVQGLKDLVWLPIEQYRRDGRIVRGLQRGAASFGTSTAMAALELTNRLVQTIQAAAETAYDMVSPGPTTHSLMRTKRISQHRLAHQPVDLREGVAKAYDVVKEGFTDTAHMIYETATREHEQRGMTGAVGGVLRQIPPAVVKPLIVATEATSNVLGGMRNQIQPDARQEESQKWRLSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAK8</accession>
    <name>A0A401QAK8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020774">
        <property type="protein sequence ID" value="GCB82415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAK8"/>
    <dbReference type="STRING" id="75743.A0A401QAK8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="14719" checksum="A662AE5487FDEF4C" modified="2019-05-08" version="1">MQADKAPGSDGIGLMQVDKAPGSDGIGLMQGDKAPGPDGIGLMQADKAPGSDGIGLMQADKAPGSDGIGLMQADKASGSDGIGLMQADKAPGSDGIGLMPADKASGPDGTNNNLFTKTPPCSSLKNESNAIFKQKYKGQKLKASNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBR3</accession>
    <name>A0A401QBR3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rabaptin coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01037420">
        <property type="protein sequence ID" value="GCB82757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBR3"/>
    <dbReference type="STRING" id="75743.A0A401QBR3"/>
    <dbReference type="OMA" id="MKVFIFH"/>
    <dbReference type="OrthoDB" id="79940at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003914">
        <property type="entry name" value="Rabaptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018514">
        <property type="entry name" value="Rabaptin_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179:SF7">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03528">
        <property type="entry name" value="Rabaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rabaptin coiled-coil" evidence="1">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="56" mass="6146" checksum="20428910E403B4BB" modified="2019-05-08" version="1" fragment="single">MASNVEALRLQLSEALAENENIKAIATVSESTKQEAIAQVKRQCQEEVASLQTIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD73</accession>
    <name>A0A401QD73_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01037259">
        <property type="protein sequence ID" value="GCB83306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD73"/>
    <dbReference type="STRING" id="75743.A0A401QD73"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF39">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="13440" checksum="C73DF8F53627C809" modified="2019-05-08" version="1" fragment="single">FFDETDEKWLSSLENTQWLEYVRLFLKHSAELTQWMYNENISVIIQEEEGRDLSCVIASVIQVMADPHFRTMLGFQSLIQKEWVVAGYRFLDRCDHLGESEKHEVRITPALPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD93</accession>
    <name>A0A401QD93_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Armadillo repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034779">
        <property type="protein sequence ID" value="GCB83368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD93"/>
    <dbReference type="STRING" id="75743.A0A401QD93"/>
    <dbReference type="OMA" id="VICIAPP"/>
    <dbReference type="OrthoDB" id="202764at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35438" checksum="D4D75314A71BEC68" modified="2019-05-08" version="1" fragment="single">MEFDSLDTILTETPLLSLLKVKELNNSVAPIGGSIVGCDLGVLLVNIFDLAPGRLTGCLTDVSVICIAPPPRDRLARTGLGVILDLAKDRDDAQLARVVTGILQHMFKHTEETSYLLITNGGLDSILYWCRSKDSTILRHCAIALANCAMHGGNANQRLMIEKKAADWLFPLAFSKDQLVRFHACLAITVLATNKEIEKEVVRSGTLELVEPFIASLHPEEFARNWLESTDNSQGRTAYDLQRLVQLLDSSTIEAQCMAAFYLCVEAGIKLKQRKTQILHEIGATQSLKRLVSYSGNVTISNLAKKALHLMGEKVPRRLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFV6</accession>
    <name>A0A401QFV6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0024972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01064982">
        <property type="protein sequence ID" value="GCB84222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QFV6"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
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        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB84222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="14260" checksum="8EA81A1EF10DAB6D" modified="2019-05-08" version="1" fragment="single">LNGCYEALDGGNTADALVDFTGGVSEPVALDEENCSGDLEKRKRLYQNLLKAHSRKSLISCSIRPESGDQLEAQMGCGLVKGHAYGVTDVRKVRIGEGLMSYFNKEKLYMVRMRNPWGSTEWNGPWSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHS1</accession>
    <name>A0A401QHS1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01108894">
        <property type="protein sequence ID" value="GCB84961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHS1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="55" mass="6200" checksum="2DE2E82EBE9DE920" modified="2019-05-08" version="1" fragment="single">MDLEPVMEDDDAAKGIKLMPLKPLTEYHQVIYCGGLLMMTKQGTSRKGLSWEKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIJ1</accession>
    <name>A0A401QIJ1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01131669">
        <property type="protein sequence ID" value="GCB85182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIJ1"/>
    <dbReference type="OMA" id="GQQETHE"/>
    <dbReference type="OrthoDB" id="8928177at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052671">
        <property type="entry name" value="Acrosomal_SP-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571:SF34">
        <property type="entry name" value="ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571">
        <property type="entry name" value="URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="286" mass="30367" checksum="3C34E78402AC4FB6" modified="2019-05-08" version="1" fragment="single">ELDGEQVDGEELDGEQVDGEQEDGEQEAGEQVDGKQVDGEQVDGKQVDGEQVDGEQVDGEQEDGEQEDGERVDGERVDGEQVDGEQEGGEQVDGKQVDGAQLDGVQVDGEQVDGELVDGEQVDGEQVDGELVDGEQVDGFQVDGEQVDGEQVDAEQVDGEQVDGEQQVDGEQEDGEQVDGERVDGEQEDAEQGDGKQVDGEQVDGEQADGELVDGEQVDGEQVDGVQVDGEQVDREELDGEQVDGEELDGKQVDGDELDGEQVNGEELDGEQVDGGQVDGTPNPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ36</accession>
    <name>A0A401QJ36_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosylmethionine synthetase central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0026083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01156645">
        <property type="protein sequence ID" value="GCB85377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ36"/>
    <dbReference type="STRING" id="75743.A0A401QJ36"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000011">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="5">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB85377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15089" checksum="C6A3F766BEC5A8CB" modified="2019-05-08" version="1">MASLLYFGTVAKTGMILLCGEITSRASVDYQKVVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRDGTLPWLRPDCKTQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ75</accession>
    <name>A0A401QJ75_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0026171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01166268">
        <property type="protein sequence ID" value="GCB85436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ75"/>
    <dbReference type="STRING" id="75743.A0A401QJ75"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB85436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="13092" checksum="50A2B9B6E8437E35" modified="2019-05-08" version="1" fragment="single">MVNNGSDQHASQFLITAGENVDYLDGVRTVFGEVTEGMDILMKINETFVDKDFYSSPEPTKEQLDSGRIGVDEEIDDTKGKTVEEIEEVLAEKEAKTRAILLEMVGDLPDAEIKPPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL61</accession>
    <name>A0A401QL61_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01243995">
        <property type="protein sequence ID" value="GCB86110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL61"/>
    <dbReference type="STRING" id="75743.A0A401QL61"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10169" checksum="A63B4903FC521DD3" modified="2019-05-08" version="1">MGPARSGPGLKGTTAGWRLPYCLSPCLFSPPTQPQDNEDLDHYEMKEEEPAEGKKSEDEGIGKENLAILEKIKKNQRQDYLNVRVGDLHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLS6</accession>
    <name>A0A401QLS6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01274261">
        <property type="protein sequence ID" value="GCB86339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLS6"/>
    <dbReference type="OMA" id="MDRTDKM"/>
    <dbReference type="OrthoDB" id="8889279at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="199" mass="23269" checksum="D88FD44E079FB1B9" modified="2019-05-08" version="1" fragment="single">AGNDYDQKSTPCKLLAEYQSERWDIIDQSERLDTKDQSERLDTMDQSERLDTMDQSERLDTMDQSERLDTMDQSERLDTMDQSERLDTMDQSERLDTMDQSERLDTMDQSGSLDTIDQSGRLDTMDQSRRLDTMDQSERLDTMDQSERLDTMDQSGRLDTMDQSKRLDTMDQSGSLDTMDQSERLDTMDQSGRLDTMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM24</accession>
    <name>A0A401QM24_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01291752">
        <property type="protein sequence ID" value="GCB86471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM24"/>
    <dbReference type="STRING" id="75743.A0A401QM24"/>
    <dbReference type="OMA" id="LMYMDLM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="119" mass="13457" checksum="B517C6D5EC14784A" modified="2019-05-08" version="1" fragment="single">MAIDLMAMDLMAMDLMAMDLMAMNLMAMDLMAMDLMAMDLMAMDLMAMDIMAMYLMAMDLMAMDLMAMDLMAMDLMAMDLMVMDLMAMDLMAMDLMAMELMAMDLMAMDLMAMDLMAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPA9</accession>
    <name>A0A401QPA9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0027995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01446308">
        <property type="protein sequence ID" value="GCB87259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPA9"/>
    <dbReference type="STRING" id="75743.A0A401QPA9"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB87259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="77" mass="9161" checksum="8345BA5AA5641052" modified="2019-05-08" version="1" fragment="single">QIMKDRWMNVGHEDDELKPYTDPEPDYKDPRRTEMMVNMGYSREEITESLVNQKYNDIMATYLLLGWKTSEVTERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPH1</accession>
    <name>A0A401QPH1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01429318">
        <property type="protein sequence ID" value="GCB87232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPH1"/>
    <dbReference type="OMA" id="VMSEGMT"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12481" checksum="7A78C5DA3D6F1C5E" modified="2019-05-08" version="1" fragment="single">MMHEEMVSEGMVSEEVLSEEVVSEVLVSEEIVNEGMVSEEVASEEMGSEKMMHEEMVSEEMVREEVVSEEVVREEMASEEMASEQMGSEEMVSEEVASDKMASEEMVSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI32</accession>
    <name>A0A401NI32_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0009188</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003684">
        <property type="protein sequence ID" value="GCB60517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI32"/>
    <dbReference type="STRING" id="75743.A0A401NI32"/>
    <dbReference type="OMA" id="LWFPDMM"/>
    <dbReference type="OrthoDB" id="9974792at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000005">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000010">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224">
        <property type="entry name" value="ES1 PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF19">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 21, PSEUDOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="443" mass="50325" checksum="87A142821BD7D29D" modified="2019-05-08" version="1">MSIIRPGRMKQNRVKQKVETQPASDADEGKKRRKTSSTPTIETLCACQVDWGNLHYDVILHIFQYLPLVDRACASSVCRTWNEVFHMPELWRRFEFELNQPATSYLKSTHPDLIQQIIKKHADHLQYVSFKVDSSTESAEAACDILSQLVNCSIKTLGLISTARPSFMNLSKSRFVSALTVVFVNSKSLSSIKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCYGLRELALNYYLLSDELLLALSSEKHVHLEHLRVNVVSENPGQTQFHSIKKSSWDALVRHSPKVSIVMYFFLYEEEFDSFFRDETPVTHIYFGRAVSKAMLGRIGINCPRLIELVVCANGLQPLDDELICIAERCKHLTAMGLGECEVSCSAFVKFVKICGRRLTQLSIMEEVLIPDQKYNLEQIHWEVSKYLGRVWFPDMMPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIG0</accession>
    <name>A0A401NIG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0006900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002414">
        <property type="protein sequence ID" value="GCB60658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIG0"/>
    <dbReference type="STRING" id="75743.A0A401NIG0"/>
    <dbReference type="OMA" id="INTGREM"/>
    <dbReference type="OrthoDB" id="2359033at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18493">
        <property type="entry name" value="BACK_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056184">
        <property type="entry name" value="TRAF_BTBD17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF12">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23651">
        <property type="entry name" value="TRAF_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019108137" description="BTB domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB60658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="482" mass="55416" checksum="3E50655A4CFFBC88" modified="2019-05-08" version="1">MFDSKSLSRMNCLLPFATLILLSAVTEGALKMDLTDDNTFATINHSSILIDHLQDLLYNSNSSDVMLKVYTGNSDEVKVFHAHHLLLILQSDVFEELLLNQSVTTLVLRETAECAALFEKLLRYLYCGEITILLNQAVPLHRLASKYHVGALQQGIIEYMSQQLARASPRGHVVSWYHYSLRIGDENLQERCKQFLAWNMSTVIHSKEWQTTSDDLMIALLQRSDLVVENELEIYYGVEEWIRRNQPDIMVAETVLKSIRYTMISPQHLFYIQKKSSIMNEHYSSIHNLFFLAFQFHSTTPPVFAKYFNVNCSLFIPRNYLSSSWGSQWVINNPVRDDRSTSFQTQLAPNNYDASKKVTWNALFSPRWLPVSVRPSYTYSGYGAARAFSPEDSRPRIIITPSTNSVSFAGVNFQKTILVRVKQDGRSYVKHIYDFHQSTEETGDFLLQADLQKPSSEYLIDKSLHLHIIIKPIYQSLIKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIY0</accession>
    <name>A0A401NIY0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005012">
        <property type="protein sequence ID" value="GCB60828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIY0"/>
    <dbReference type="STRING" id="75743.A0A401NIY0"/>
    <dbReference type="OMA" id="FVHITHF"/>
    <dbReference type="OrthoDB" id="5559822at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF6">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="11">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="77" mass="8935" checksum="1C9EA2FEBF24982F" modified="2019-05-08" version="1">MSEFWLCFNCCIAEQPQPKRRRRIDRSMIGEPTNFVHTSHMGAGDMFGDRMNSVIDHSVTWLTNNITQITLSSLKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ84</accession>
    <name>A0A401NJ84_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0012823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006325">
        <property type="protein sequence ID" value="GCB60932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ84"/>
    <dbReference type="STRING" id="75743.A0A401NJ84"/>
    <dbReference type="OrthoDB" id="7788762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19696">
        <property type="entry name" value="bHLH-PAS_AhR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000024">
        <property type="entry name" value="Aryl hydrocarbon receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF18">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR 1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="18022" checksum="335A12CC571E28A5" modified="2019-05-08" version="1">MERMQRALSAQVFWTRRAPARGNARSRCSSPRCRTGCAEPEPSFTDHNPEERALSLDSGRIDAAPGVRQSPVPINMYPGRKRRKPVQRAVKPVLADGIKSNPSKRHRDRLNCELDRLACLLPFTEDVTSSLDKLSILRLSVSYLRSKTFFRGELRGDMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK72</accession>
    <name>A0A401NK72_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the translokin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005076">
        <property type="protein sequence ID" value="GCB61311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK72"/>
    <dbReference type="OMA" id="DGMNELP"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000003">
        <property type="entry name" value="Centrosomal protein of 57 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF10">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP57L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB61311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="191" mass="21794" checksum="2CCA6AE02B68395B" modified="2019-05-08" version="1">MMSDGRQKLPVQRTPQNSRKTTYDSGKVKNGDLHFVSPYSSASSPTEGLTEILLALQDELGQMSFEHQDLLKQIQGTKNTDVREDLERELDCLVKRMEKKADQISKLRKHQDKVEKLKVKAKKMTREMADAKKRAKALDEMKEVPANPRGTEFSVKTTSAPGQKGKESLQLLRNAQKLQLTLRQNDITWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKG4</accession>
    <name>A0A401NKG4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0009316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the tectonic-like complex (also named B9 complex).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tectonic family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003778">
        <property type="protein sequence ID" value="GCB61337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKG4"/>
    <dbReference type="STRING" id="75743.A0A401NKG4"/>
    <dbReference type="OMA" id="AGDVKIC"/>
    <dbReference type="OrthoDB" id="2104337at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057724">
        <property type="entry name" value="TCTN1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF1">
        <property type="entry name" value="TECTONIC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25752">
        <property type="entry name" value="DUF1619_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019273656" evidence="6">
        <location>
            <begin position="23"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3 N-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="7">
        <location>
            <begin position="208"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="7">
        <location>
            <begin position="383"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB61337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="590" mass="63971" checksum="12C1A12925F1FC02" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLS5</accession>
    <name>A0A401NLS5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the YTHDF family. YTHDF2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005146">
        <property type="protein sequence ID" value="GCB61835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLS5"/>
    <dbReference type="STRING" id="75743.A0A401NLS5"/>
    <dbReference type="OMA" id="HAYRHTT"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000001">
        <property type="entry name" value="YTH domain family 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF8">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="11">
        <location>
            <begin position="398"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB61835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="567" mass="61819" checksum="354B274FB20E57BB" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMU7</accession>
    <name>A0A401NMU7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP-ribosylation factor-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0009473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003874">
        <property type="protein sequence ID" value="GCB62179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMU7"/>
    <dbReference type="STRING" id="75743.A0A401NMU7"/>
    <dbReference type="OMA" id="QEDISHM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04155">
        <property type="entry name" value="Arl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000281">
        <property type="entry name" value="ADP-ribosylation factor-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB62179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="20446" checksum="E9D3FFF3027DA691" modified="2019-05-08" version="1">MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWRNYFENTDVLIYVIDSADRKRFEETGQELAELLDEEKLSAVPVLVFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNIHAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNG0</accession>
    <name>A0A401NNG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0011459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005218">
        <property type="protein sequence ID" value="GCB62406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNG0"/>
    <dbReference type="STRING" id="75743.A0A401NNG0"/>
    <dbReference type="OMA" id="PNTECAN"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF27">
        <property type="entry name" value="SEMAPHORIN-3F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="3">
        <location>
            <begin position="49"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="327" mass="37358" checksum="71229427E9D0F37F" modified="2019-05-08" version="1">MSLNETWMTRTVKFEENLKCRASIATERSEGSCFFAIGWLQLPWTAFCPPGSSFKELQHSNTARHYTLLQNTTDYRILLMDEDHDRMYVGTKDYIVSLDLHNINREPLLIHWSISQQRRDECVLSGKDQNGECANFICLIEPWNRTHLYVCGSGAYHPVCTYVNRGRKAEDYIFHLEPGKVESGKGKCSYDPKLDSVSSLINGELYAGVYIDFMGTDAAIFRTMGKQTAMRTDQYNSRWLNDPAFVHAQLIPDSGERNDDKLYFFFREKSSDSGSSAIHSRIGRICLNDDGGHCCLVNKWSTFLKARLICSVPGPDGIETHFDELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP64</accession>
    <name>A0A401NP64_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006558">
        <property type="protein sequence ID" value="GCB62675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP64"/>
    <dbReference type="STRING" id="75743.A0A401NP64"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="142" mass="16501" checksum="C54B1831DD4705BC" modified="2019-05-08" version="1">MNSFFFCFKIKRLKEKTARKATRKKDQPEEETVAYLEQSDASDEFDPADLPDPDKYRDYKEHDSHDISEAEDNRSKPVEGGFKRKRNDSCSSNDECEEMIAAQKAKRRMNSEIDSDEHRPLDTGLSLAEDEELVLHLLNSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPD6</accession>
    <name>A0A401NPD6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tumor necrosis factor alpha-induced protein 8-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001264">
        <property type="protein sequence ID" value="GCB62726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPD6"/>
    <dbReference type="OMA" id="TMRSHAR"/>
    <dbReference type="OrthoDB" id="10055976at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.160:FF:000001">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757:SF5">
        <property type="entry name" value="TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757">
        <property type="entry name" value="TUMOR NECROSIS FACTOR INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23125" checksum="527086F29CD83109" modified="2019-05-08" version="1">MDLESGELSEGDLSSGGTESFNSKSLALQAQKKILSKMATKAMANMLIDDTSSDILDELYKVTRDYTSDKKEAHKVLKDLIKIALKIGILYRNNQFNQDEAEIVDKFKKKLNQAAMTAVSFYEVEFTFDRNILSGLLHECKDLLHELIERHLTPKSHGRIDHIFRLFAKVEFLSDLYNPEGVYKVYLQKICEGVNKLLDEGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPT0</accession>
    <name>A0A401NPT0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0000077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000013">
        <property type="protein sequence ID" value="GCB62908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPT0"/>
    <dbReference type="STRING" id="75743.A0A401NPT0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB62908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="141" mass="15576" checksum="DFB6D08F77DB1893" modified="2019-05-08" version="1">MSGRGKGGKGLGKGGAQQHRKVLRDNSQGLTKPASGRLARRGRVKHISGLSYEETRGVLKVFLENVIRNTVIYTEHGKRKTVTAVDVVYALKRQSRTLYGFSGGTTRPFRPNTTTKALIRASHHLTERAVTGNGSWNWECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NR41</accession>
    <name>A0A401NR41_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TPT transporter family. SLC35E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005333">
        <property type="protein sequence ID" value="GCB63358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NR41"/>
    <dbReference type="STRING" id="75743.A0A401NR41"/>
    <dbReference type="OMA" id="CIRRFTA"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="187" mass="20910" checksum="A4E7B854BAA54B36" modified="2019-05-08" version="1">MGQNFKMRIPITLGVVLNSYFDVKFNFLGILFAILGVLVTSVYQVWVGAKQHELQVNSMQLLYYQAPMSSAILMFIVPFFEPVTGEGGIFGNWSGTTLMMVLLSGIIAFLVNLSIYWIIGNTSPVTYNMFGHFKFCITLLGGYILFKDPLSLNQGLGILCTLCGILLYTHFKLSEQEEGQNKLAQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSA8</accession>
    <name>A0A401NSA8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0014676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007966">
        <property type="protein sequence ID" value="GCB63755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSA8"/>
    <dbReference type="STRING" id="75743.A0A401NSA8"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF6">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB63755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21627" checksum="2A86A7121AE9FE85" modified="2019-05-08" version="1">MDDAYRDRTTLMRGAKDIAKEVKKQTVKKASRGADHTQAEYNKTSYANFQDDDGYNYHGGTYGQEPQEDEGSSDATEGHDEEDEIYEGEYQGIPDVGQRKENQVAIGQPVSDEYKDREELDAERRADEEELAQQYELIIQECGHGRFQWALFFVLGLSLMADGVEVFVVGFVLPSAETDMCVENSSTGWLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSM8</accession>
    <name>A0A401NSM8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005396">
        <property type="protein sequence ID" value="GCB63860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSM8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="9471" checksum="7354354BE4183724" modified="2019-05-08" version="1">MNNFTGYLSVHTEAANIVELAKQVRGERFVELATDEAEELLQPHGEEPFAEDLVELMKLSEFKQEQEEDPKTRDDSRRHKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSW6</accession>
    <name>A0A401NSW6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0009752</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004062">
        <property type="protein sequence ID" value="GCB63988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSW6"/>
    <dbReference type="STRING" id="75743.A0A401NSW6"/>
    <dbReference type="OMA" id="LEGVRYC"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07861">
        <property type="entry name" value="STKc_CDK1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000231">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB63988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="301" mass="34659" checksum="E7B9A627A86BAACB" modified="2019-05-08" version="1">MDDYVKIEKIGEGTYGVVYKGRHKTTQQIVAMKKIRLESEEEGVPSTAIREISLLKELQHPNIVCLQDVLMQDARLYLIFEFLSMDLKKYLDSLPTRQMMEQMLVKSYLYQITQGIAFCHSRRVLHRDLKPQNLLIDSKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSARYSTPVDIWSIGTIFAEMATKRPLFHGDSEIDQLFRIFRTLGTPNNEIWPEVETLPDYKNTFPKWKAGSLSQVKNIDVNGLDLLAKTLIYNPARRISAKEALRHPYFDDLDKSNLPANIQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT40</accession>
    <name>A0A401NT40_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004069">
        <property type="protein sequence ID" value="GCB64063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT40"/>
    <dbReference type="STRING" id="75743.A0A401NT40"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46491" checksum="04497A47AAA5A0FF" modified="2019-05-08" version="1">MIYKRENPHVSLHYVMAYIGVQEKAFLICQVIHFHLGCSVKVMEFAYSHIVYNSQNTPSPNCRNREREQRHDRPAVIPDPVENQTYSSTSFRPPPTQARGSIHQYDNRFLKSPSNEENCLYATVPKSSHSRSQAKLPKPLAKTRKSIPIDDEDSQAPPLPPRPSSLTTHQLDATVPGTLNSHPQIPPPRPKRAFPAPKRSSSPMTKKANINVVSVNLGKLVDINDEGAQTVKAIYCQNCSAALSSISRIHQKYADIIWPCEFCKKHNVVTRSFSTIPNSQDVMYVSGSLNEDYMNVDDSLVVFCVDISGSMCATNEIEVADEGSRTVHISRLQSVQEAILRSLNHMTQTSPQKRVALVTFNDEVTIYGDGLCEPTRLSDYQLLDSDYLKTRGREYPVPRCIAESLHALNYRVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUU6</accession>
    <name>A0A401NUU6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000058">
        <property type="protein sequence ID" value="GCB64639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUU6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB64639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="88" mass="9972" checksum="BC945717EC07568B" modified="2019-05-08" version="1">MGRVLEGQVLLQGRDVEGRVLEGRILGGRVLEEHVLEERVLLQRRVLEGRVLEEQVLEGRVLLQGRVVEGRVLEEQVLEGWVLLQGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW63</accession>
    <name>A0A401NW63_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004168">
        <property type="protein sequence ID" value="GCB65111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW63"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="51" mass="5833" checksum="B75ACEC7932CD1FC" modified="2019-05-08" version="1" fragment="single">GETGKKAAAKPAQTVKKKQEEEEEEEDEDEEDEDEEDDDDDEEEGDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW92</accession>
    <name>A0A401NW92_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0013417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01006840">
        <property type="protein sequence ID" value="GCB65104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW92"/>
    <dbReference type="STRING" id="75743.A0A401NW92"/>
    <dbReference type="OMA" id="SMTQFGQ"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00826">
        <property type="entry name" value="nondecarbox_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="272"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB65104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="411" mass="44336" checksum="8E1F20771D294B2E" modified="2019-05-08" version="1">MAAAKSRVFVVGVGMTKFEKPGALEDVDYPDMAKEAAQKALADAGIAYNAVEQACVGYVYGDSTCGQRAIYHSLGTTGIPIINVNNNCSTGSTALFMARQLIQGGLADCTLALGFEKMERGSLSSKYTDRTNPMDKHCEVLNNKYGISAAPIAPQLFGSAGKEHMEKYGTKPEHFAKIAWKNHKHSTNNPYSQFQDEFSLDQVMKSRQIFEFLTLLQCCPTSNGAGAAVLASEKFVLRHGLESKAVEILAQEMITDLPSSFQENSCIKAVGFDMTKEAARKCFQKTGLQPNDVDVIELHDCFSANELITYEALGLCSEGKAGQLIDKGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEARKRQVPGAKVALQHNIGLGGAVVVTIYRMGFPQAARKESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW95</accession>
    <name>A0A401NW95_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MAP7 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004171">
        <property type="protein sequence ID" value="GCB65155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW95"/>
    <dbReference type="STRING" id="75743.A0A401NW95"/>
    <dbReference type="OMA" id="WVPRISG"/>
    <dbReference type="OrthoDB" id="10066352at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF2">
        <property type="entry name" value="MAP7 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB65155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="81117" checksum="29F1493353B9EBE0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWM6</accession>
    <name>A0A401NWM6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0000403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000074">
        <property type="protein sequence ID" value="GCB65276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWM6"/>
    <dbReference type="STRING" id="75743.A0A401NWM6"/>
    <dbReference type="OMA" id="TDINQRC"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB65276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117038" checksum="7901A20AB5A5FD94" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWT5</accession>
    <name>A0A401NWT5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0013443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006869">
        <property type="protein sequence ID" value="GCB65339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWT5"/>
    <dbReference type="STRING" id="75743.A0A401NWT5"/>
    <dbReference type="OMA" id="KHASKMV"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF177">
        <property type="entry name" value="CYTOCHROME P450 2J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB65339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53452" checksum="EE6FF531748D6EB4" modified="2019-05-08" version="1">MNLVNSGELGTGVHNFFVFHSSLPEKKLSKKYGNLFTCYIFCIPFVVINGFEIIQEALVQQGREFAGRPYLPLIEEITKGQGIIMAPYGRSWKQQRRFTLTALRNFGLGKIAFEEKILQEAQYLTEVFQASIGQPFNPNSKITSAVSNVICSIVLGKRFHYEDEVFTQLVELIDENMRLQTTIWALVYFVTPLIGYFPGPHQRIFKNQARINAFLQDFINQHKDTLNGEEIRDFIDAYLLEMEKEQNSPNCCLTEGNLMQIVNDLFTAGTETTTTTLQWAILYMMAYPDIQESCQKEIDQVIGWSRTPSMEDAPNMPYVNAVVHEVQRFGNVAPISVGHATTRDTSFRGYTIKKGTMILINMPSVLSEETQWKDPKHFNPGNFLNENGEFFKPDAFIPFSVGLRACPGEKLARMELFLFFASLLQNFEFYWPDKTSTPDLEGVYKLTLAPRPYKMAIRCRKPSDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX51</accession>
    <name>A0A401NX51_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004201">
        <property type="protein sequence ID" value="GCB65451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX51"/>
    <dbReference type="STRING" id="75743.A0A401NX51"/>
    <dbReference type="OMA" id="HWDGMAV"/>
    <dbReference type="OrthoDB" id="5971337at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042161">
        <property type="entry name" value="TTC34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44874">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44874:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117701" checksum="4C94B555BC9C60CD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZA4</accession>
    <name>A0A401NZA4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0011973</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005643">
        <property type="protein sequence ID" value="GCB66218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZA4"/>
    <dbReference type="STRING" id="75743.A0A401NZA4"/>
    <dbReference type="OMA" id="LKFAFRM"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000093">
        <property type="entry name" value="Calcineurin B homologous protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB66218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="22588" checksum="8E209E68F0A25535" modified="2019-05-08" version="1">MGSRASSLLREEEIEEIKKETGFSHSQITRLYSRFTSLDKGENGTLCREDFQRIPELAINPLGDRIINAFFPESEDQVNFRGFMRTLAHFRPIEDSDKSKDPLVPEPLNSRNNKLLFAFRLYDLDKDDKISREELLQVLRMMVGVNISEEQLGSIADRTIQEADQNGDLSISFTEFQKVLEKVDVEQKMSIRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0B3</accession>
    <name>A0A401P0B3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="38">G-protein coupled estrogen receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="39">G protein-coupled estrogen receptor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="40">G-protein coupled receptor 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="ORF">scyTo_0007895</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="44 45" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Dendritic spine membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="37">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="41">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="44">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002944">
        <property type="protein sequence ID" value="GCB66543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0B3"/>
    <dbReference type="STRING" id="75743.A0A401P0B3"/>
    <dbReference type="OMA" id="GLESIMC"/>
    <dbReference type="OrthoDB" id="5957382at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
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            <begin position="64"/>
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        <source>
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        <source>
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    <sequence length="357" mass="41174" checksum="15828C9E984765C8" modified="2019-05-08" version="1">MEVHLVSRILLFSNESELNKSSYCNETLHCGQVTENQRDSYFYNISLFLSCLYTIFLFPIGFIGNGLILVVNLNDHKKMTIPDLYFVNLAVADLILVADSLIEVFNLNDKYYDIAILCTFMSLFLQINMYSSIFFLTWMSFDRYLALAQSMKSGTLRTLRHAKWSCGLIWLTSILAAMMPFAVVQAHHTGEVHFCFADVMEIQWLEVTLGFVIPFFIIGLCYSLIVRILTNAQKHNRLWPRRQKALRMIVVVVLVFFICWLPENVFISLQLLQGTKDSSVSLKESMGHYYPLTRHIVNLAAFSNSCLNPIIYSFLGETFRDKLRLYMKRKASVSTVYRLCNNTLNWNIPVAAEESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1E3</accession>
    <name>A0A401P1E3_SCYTO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000128">
        <property type="protein sequence ID" value="GCB66930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="79" mass="8734" checksum="216BF27BDEA48F32" modified="2019-05-08" version="1">MKLAARAPEQRKYRAHLESKEQTLKGEQTATFSGEDLGGGHNGCPGENNRLRDEGRESTYWFGADMACGQQSGPCFRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2R5</accession>
    <name>A0A401P2R5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 121B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005767">
        <property type="protein sequence ID" value="GCB67397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2R5"/>
    <dbReference type="STRING" id="75743.A0A401P2R5"/>
    <dbReference type="OMA" id="VFMFKNV"/>
    <dbReference type="OrthoDB" id="5964337at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026624">
        <property type="entry name" value="CECR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42817" checksum="F45D30316092516C" modified="2019-05-08" version="1">MSAAAANESSRSAAPAPSEAEGNLRAAENDSLFIRNSSFRRNSQTSTASLSREVGAASNIKARPAFIITSGEFLQQSSACTSSPGPAASGRSLLYKGLCLLLLLCQGGLLDFYLIIFTDLYWCSWIATDLVVVAGWLIFFIKHSRRRGAGDKAAPGAGHSGQFAFAYLAWLIYVIACTPKIVLILETSILDLIELKVPLGTTGFKIVVMSSVPLLYTLINSVTEELGCQNSHRAQNYYSRTCLDLLDTFTLMELMLSGHIPSVYLKYTVTTVYFVAFFIPVLWLYELNSLQLHYKCVVFRFLSSSAVNAPLLAVRCFLVFLYDQQVSVFLLKNVFWLFCDCAEVLEGCCSVRRVRKYSSPPVQFTHCVSDNEMCAHGYMNTLAVTAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3E3</accession>
    <name>A0A401P3E3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004394">
        <property type="protein sequence ID" value="GCB67631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3E3"/>
    <dbReference type="STRING" id="75743.A0A401P3E3"/>
    <dbReference type="OrthoDB" id="15627at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032034">
        <property type="term" value="F:myosin II head/neck binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000041">
        <property type="entry name" value="LIM and calponin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551:SF3">
        <property type="entry name" value="LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551">
        <property type="entry name" value="LIM DOMAIN ONLY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="207"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB67631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="279" mass="31623" checksum="8F8E851693D5AFA2" modified="2019-05-08" version="1" fragment="single">VETESWQAEGKGRMQDEEERQWQKGGQQKLTWEQKETLGFKKDEDGQQENRDETEQNKLEKWHWQETKQLGSEEQRYMLNLQSEIDIFQMDKEAVSESQNQTDWQTPSSGHQQLPAQAARSPVITGRSWNTQEFPSFLEVQRKQQQGLQDGLKTGSLDRNWALQCSMMDRKKWSGSHENLQSGQSLPLPHSSPLPLQSPSRSVSGKKLCSTCGLPLGKGAAMIIETLSLYFHIQCFTCGICQGQLGDATTGTDVRIRNGLLNCNDCYIRSRTAGQPTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5A6</accession>
    <name>A0A401P5A6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008511">
        <property type="protein sequence ID" value="GCB68297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5A6"/>
    <dbReference type="STRING" id="75743.A0A401P5A6"/>
    <dbReference type="OMA" id="LQYGTQD"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="363" mass="39848" checksum="4A7B71E5C4587D26" modified="2019-05-08" version="1">MATLAVSLVYRHGRLMAGKRAKLTSCLQQKLCRPCPFSTISTKMNRAAIERSMPLSAWESFGIWLDDPVVLPPRISALQYKEKIANIGCVSQIGKRRENEDRFSIAELSAGLVCFAVFDGHGGTDAAEVCSRYIGHYIQQNLQRETDLEKVLLNSFLQMDSDFIQNVYGLKEGALLTSGTTATVALLNETLLIVASVGDSPAILCHEGKAKQLTDDHTPRRRDEQKRIKDCGGFIDWNSAGDPYVNGRLAMTRSIGDVDLKPFGVTARPDVNTVELDHTKDCFLILTTDGVSGIIEAQEVCDIVKRCQDPSEAAAVVNEQALQYGTQDNVTTMVVPFGAWGKHSTSLAHTSFGRMMVASSRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5R2</accession>
    <name>A0A401P5R2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0012289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005884">
        <property type="protein sequence ID" value="GCB68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5R2"/>
    <dbReference type="STRING" id="75743.A0A401P5R2"/>
    <dbReference type="OMA" id="VPQACCA"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19397">
        <property type="entry name" value="TGF_beta_BMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000003">
        <property type="entry name" value="Bone morphogenetic protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF135">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0891">Chondrogenesis</keyword>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0339">Growth factor</keyword>
    <keyword evidence="6" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="13">
        <location>
            <begin position="178"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="298" mass="34088" checksum="165A12210E98A9BE" modified="2019-05-08" version="1">MDIDLSVEYDKEIFHQRRHHREFKFDLSKIPEGEAVTAAEFRIYKDYTRERFVNETFQITIYQVLEENTESESDLFPLDTRTIWAAEEGWLVFDITATSNHWVVNPNNNLGLQLFVQTTTGQSVNPKMASLIGRLGPQNKQPFMVAFFKATEVHIRSTRSAGGKHKNQGRSRSSKSQESLRATSLAENSSSDQRQACMKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECSFPLNSYMNATNHAIVQTLVHLINPENVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6C4</accession>
    <name>A0A401P6C4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0013857</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01007249">
        <property type="protein sequence ID" value="GCB68675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6C4"/>
    <dbReference type="STRING" id="75743.A0A401P6C4"/>
    <dbReference type="OMA" id="EHDVEHW"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF7">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="13">
        <location>
            <begin position="127"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="14">
        <location>
            <begin position="294"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB68675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="482" mass="55240" checksum="204AB92DAB72D77B" modified="2019-05-08" version="1">MADENETATKEIEELDGCGSDCENEEEHALSKGNPGDDTGAKKKKKKPKRKKEKGGGKLDSDDQSKVNSLPAEKLQEIQKAIELFSVAQGPAKSMEEATKRSYQFWDTQPVPKLGEVVTVHGPIEPDKDNIRQEPYSLPQGFLWDALDLGNAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLPWHCGVRVVSNKKLVGFISAIPANIQIYDHLKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGSYQAVYTAGVVLPKPVGTCRYWHRSLNPRKLVEVKFSHLSRNMTMQRTMKLYRLPETTKTPGLRPMESKDVEGVCRLLREYLKLFHLTPAMNKEEVAHWFLPRENIIETYVVENHDGELTDFFSFYTLPSTIMHHPVHKSLKAAYSFYNVHTKTPLVDLMNDGLILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMAAEKVGLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6D7</accession>
    <name>A0A401P6D7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="13">HIU hydrolase</shortName>
            <shortName evidence="13">HIUHase</shortName>
            <ecNumber evidence="6 13">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0010432</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="6 13"/>
    <dbReference type="EMBL" id="BFAA01004496">
        <property type="protein sequence ID" value="GCB68640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6D7"/>
    <dbReference type="STRING" id="75743.A0A401P6D7"/>
    <dbReference type="OMA" id="HDGRCDA"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.180:FF:000004">
        <property type="entry name" value="5-hydroxyisourate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF11">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8 13" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB68640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13505" checksum="03ABA5B455B037F7" modified="2019-05-08" version="1" fragment="single">GDSPDCRMTPSPLTTHILNTAQGVPAAHVAVSVYRVEDKAWREIARGATNSDGRCPGLLTSETFVPGIYKMKFATDEYWQSLKMTSFYPYIEVVFNISDASQKYHIALLLTPFSYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7B5</accession>
    <name>A0A401P7B5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor Maf</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0000987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000203">
        <property type="protein sequence ID" value="GCB69027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7B5"/>
    <dbReference type="STRING" id="75743.A0A401P7B5"/>
    <dbReference type="OMA" id="HQHMRLE"/>
    <dbReference type="OrthoDB" id="5974330at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000016">
        <property type="entry name" value="MAF bZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013592">
        <property type="entry name" value="Maf_TF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08383">
        <property type="entry name" value="Maf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="238"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB69027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="323" mass="35890" checksum="94721AE36ECDD0BD" modified="2019-05-08" version="1">MASELAINNADLPNSPLAMEYVNDFDLMKFEVKKEPVDSEGNPGSHCNRIGGSLSSTPMSTPCSSVPPSPSFSAPSPGEQKAAHLEDFYWMTNYQQLNPDALSFTPEDAVEALINSAHQQMQAGFEGYRSQQQYAPAAGAGMAGDEMPPAGTVVPHHHHHQQQQQHHHHHHQGHQHPGGGVAALGTPNTGTATGGGTGGGMHPHLRNDDRFSDDQLVTMSVRELNRHLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHMLESEKTQLQQQVEHLKQEISRLVRERDAYKEKYEKLVTSGFRETGSSSDNPSSPEFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7B6</accession>
    <name>A0A401P7B6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004535">
        <property type="protein sequence ID" value="GCB69041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7B6"/>
    <dbReference type="STRING" id="75743.A0A401P7B6"/>
    <dbReference type="OMA" id="THSKRGE"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000005">
        <property type="entry name" value="Contactin associated protein-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF40">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="5">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="435"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB69041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="560" mass="62327" checksum="0C84C1C114CF752A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8E6</accession>
    <name>A0A401P8E6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">palmitoyl-CoA hydrolase</fullName>
            <ecNumber evidence="7">3.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01003197">
        <property type="protein sequence ID" value="GCB69431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8E6"/>
    <dbReference type="STRING" id="75743.A0A401P8E6"/>
    <dbReference type="OMA" id="RHTNSAR"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000009">
        <property type="entry name" value="Cytosolic acyl coenzyme A thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000010">
        <property type="entry name" value="Cytosolic acyl coenzyme A thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF24">
        <property type="entry name" value="CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="9">
        <location>
            <begin position="186"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640170-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="321" mass="35481" checksum="E376149D8AE89195" modified="2019-05-08" version="1">MEGSAKSFYQSPGCCIQVSRIMRPDDANIAGNVHGGTILKMIEEAGVIISTRHCNKQNDERCVAALARVERTDFLSPMSIGDVAHVSAEITYTSKHSVEIQVNVMAENILTGAKRLTNRATLWYVALSLENVDKVVEVPSIEYESSELQEEGRKRYEAQKLDRIETKLRSEDIILPAINVEPYTVGYSQSSLIHLVGPSDCALHKFVQGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHQKIQKGSVITVSGRMTFTSNKSMEIEVFVDVDHVMESPKGKASAVTAFFTYVSLDKEGKALPIPMLKVRIYLHLCYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8N2</accession>
    <name>A0A401P8N2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial brown fat uncoupling protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0008395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003203">
        <property type="protein sequence ID" value="GCB69499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8N2"/>
    <dbReference type="STRING" id="75743.A0A401P8N2"/>
    <dbReference type="OMA" id="IKYRGVW"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000008">
        <property type="entry name" value="Mitochondrial uncoupling protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="149"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="248"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB69499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37120" checksum="108D5C805261DF0F" modified="2019-05-08" version="1">MCNGVKVRITNCSQTSLQASTPPLKHFAKTVAKMVGLKPSSIPPTPGVRFLSAGTAACIADLITFPLDTAKVRLQVQGETTGSPGAGIAKSIKYRGVWGTVSTIIKTEGARSLYNGLVAGLQRQMSFASIRIGLYDSVKQFYTRGSDHASMMTRLLAGCTTGGLAVILAQPTDVVKVRFQAQRNLWGAPKRYNGTFQAYKSIAKDEGVRGLWKGTFPNITRNAIVNCSELVTYDIIKETILRKKLLTDTFPCHFISAFGAGFCATVAASPVDVVKTRYMNSAPGHYKSALNCAWTMLVSEGPTAFYKGFLPSYLRLGSWNVLMFVTYEQLKRAMMMYRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P961</accession>
    <name>A0A401P961_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000232">
        <property type="protein sequence ID" value="GCB69624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P961"/>
    <dbReference type="OMA" id="RISLFYC"/>
    <dbReference type="OrthoDB" id="10440912at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="11982" checksum="CC3F2D4F0432DC96" modified="2019-05-08" version="1">MGVGCAVRAGDADGGAVDVEVGDSGGDDDKEVGEAGSVACDRIGSEVHAAAVSAPLSGRGDVQLRNVADVVDTEPAEMSLVQNNPGKRISLFYCQTKNQAVMMNLSTSGEDGLDTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9W4</accession>
    <name>A0A401P9W4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>coproporphyrinogen III + O2 + 2 H(+) = protoporphyrinogen IX + 2 CO2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:18257"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="1.3.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18258"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01003252">
        <property type="protein sequence ID" value="GCB69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9W4"/>
    <dbReference type="STRING" id="75743.A0A401P9W4"/>
    <dbReference type="OMA" id="VHANWRY"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="419" mass="46776" checksum="176B74F2A69E9DDB" modified="2019-05-08" version="1">MSQLVALSALSRCGSRLALSNAGGAAACRPYSGARRLTGGFYKPFLLGSAALVGATVAGFGLSRSRAVLAAKSVRTPAERDQRELNEILQKCKHFMSDPVTDINKLLENKDDMRTKMELLVMDVQADVCKALAEVDGGQTFKVDRWHRKEGGGGISCVLQDGKVFEKAGVNVSVVFGNLSEEATKQMRSRGKSLKSKDGKLPFCAMGVSSVIHPKNPHIPTIHFNYRYFEIEEADGHKSWWFGGGTDLTPTYLNKDDAIHFHKTLKEACDKHDQSYYPTFKKWCDDYFTIKHRGERRGVGGIFFDDLDSPSAEGLFGFVQSCAKAVVPCYIPIVKKHLHDSYTPEEKAWQQLRRGRYVEFNLVYDRGTKFGLATPGSRIESILMSLPLTARWEYMHDPAKGTKEAEIIEVLKNPKDWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PA26</accession>
    <name>A0A401PA26_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Extended synaptotagmin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0008484</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the extended synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003257">
        <property type="protein sequence ID" value="GCB69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PA26"/>
    <dbReference type="STRING" id="75743.A0A401PA26"/>
    <dbReference type="OMA" id="GHMWPYL"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08391">
        <property type="entry name" value="C2A_C2C_Synaptotagmin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04050">
        <property type="entry name" value="C2B_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04030">
        <property type="entry name" value="C2C_KIAA1228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000025">
        <property type="entry name" value="Extended synaptotagmin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000093">
        <property type="entry name" value="Extended synaptotagmin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000114">
        <property type="entry name" value="Extended synaptotagmin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037752">
        <property type="entry name" value="C2C_KIAA1228"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037733">
        <property type="entry name" value="Ext_Synaptotagmin_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037749">
        <property type="entry name" value="Ext_Synaptotagmin_C2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF4">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="19">
        <location>
            <begin position="124"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="301"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="445"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="732"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="627"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="869" mass="99146" checksum="C3633C6E036F1454" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB78</accession>
    <name>A0A401PB78_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline ceramidase</fullName>
            <ecNumber evidence="12">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0001261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:41299"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41300"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:20857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an N-acylsphinganine + H2O = sphinganine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:33551"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33552"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BFAA01000275">
        <property type="protein sequence ID" value="GCB70373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB78"/>
    <dbReference type="STRING" id="75743.A0A401PB78"/>
    <dbReference type="OMA" id="EMLWCEN"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139">
        <property type="entry name" value="ALKALINE CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139:SF1">
        <property type="entry name" value="ALKALINE CERAMIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB70373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="13463" checksum="DFFE06850A924475" modified="2019-05-08" version="1">MEPVQEMLWCENVRVYKLGLLAGFWWALALLCWISDNLFCELWSAFNFPYLHCAWHILICLAAYLGCVCFAYFDAVSEIPEQGPVIKFWPSEKWAFIGVPYVSLLFAENKSQLKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBA9</accession>
    <name>A0A401PBA9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0008569</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003310">
        <property type="protein sequence ID" value="GCB70403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBA9"/>
    <dbReference type="STRING" id="75743.A0A401PBA9"/>
    <dbReference type="OMA" id="CKRIKKX"/>
    <dbReference type="OrthoDB" id="536399at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd16697">
        <property type="entry name" value="RING-CH-C4HC3_NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF1">
        <property type="entry name" value="NF-X1-TYPE ZINC FINGER PROTEIN NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="804"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="892" mass="99533" checksum="022FE7711FFC53F2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBE0</accession>
    <name>A0A401PBE0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003316">
        <property type="protein sequence ID" value="GCB70438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBE0"/>
    <dbReference type="STRING" id="75743.A0A401PBE0"/>
    <dbReference type="OMA" id="EWQEVHS"/>
    <dbReference type="OrthoDB" id="9940536at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="290" mass="32706" checksum="CB5FDE1F02E856C0" modified="2019-05-08" version="1">MGCGTSRAVSTQPEAGTEDSLERKRKIKNNRKSSRLNIIDDSPGSKVSEEDLITLPGAVQQSLPPLRKANGTLLQNGFNDDLALTASSLLKKNGPVHEIRERPRSVDILQELLVQGILNQAHSEEWQEVHSPLFDMKSTEGILKKPPTRLDKLRNETAKQKNVTIEEIENKMIAAEERRKMKEVKLKERLNKFNSSPVMMQDEPTEVPLEPDHANLEEVVEKINAKHKEIQQEQQEIAKENDESDDLVDKTGINQPERKVNAEDCCEVVELNDGHYLATKVADEVIVNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBK4</accession>
    <name>A0A401PBK4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FERM and PDZ domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0005687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001813">
        <property type="protein sequence ID" value="GCB70489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PBK4"/>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06769">
        <property type="entry name" value="PDZ_FRMPD1_3_4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000066">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000053">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049385">
        <property type="entry name" value="FAK1-like_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF1">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21477">
        <property type="entry name" value="FERM_C_FAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="204"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="205"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB70489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1840" mass="205717" checksum="94172630C3D424F3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBZ7</accession>
    <name>A0A401PBZ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maternal embryonic leucine zipper kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0008627</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01003348">
        <property type="protein sequence ID" value="GCB70637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBZ7"/>
    <dbReference type="STRING" id="75743.A0A401PBZ7"/>
    <dbReference type="OMA" id="NVCTPKS"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12198">
        <property type="entry name" value="MELK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14078">
        <property type="entry name" value="STKc_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14341">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000901">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000004">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034673">
        <property type="entry name" value="MELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048637">
        <property type="entry name" value="MELK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21594">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="12"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="20">
        <location>
            <begin position="604"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB70637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="653" mass="74603" checksum="C6584951BB8AF012" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCI3</accession>
    <name>A0A401PCI3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neuferricin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cytochrome b5 domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-binding protein which promotes neuronal but not astrocyte differentiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004780">
        <property type="protein sequence ID" value="GCB70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCI3"/>
    <dbReference type="STRING" id="75743.A0A401PCI3"/>
    <dbReference type="OMA" id="GHKHYGP"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="70"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="294" mass="32149" checksum="61345AA8F3DD867B" modified="2019-05-08" version="1" fragment="single">GSWRRGLGSWRRAPGAAAMLQPLLLCLLCVSVALLLPLDVWSLLNRCFAGWFEGAAGSPLGARSTPSRLFTKSELSRYTGEKGSEGLYLAVLGQVFDVSKGKKHYGPGGSYSFFAGRDACRAFVSGDFTENGLVDDVSGLSPSEMLSLQEWLAFYKKEYLFKGKLIGPYYDHTGEATQALIDIELTVMHCKKLKAESELENKIFPSCNSEWTSTKGGRVWCSSRSGGIERNWAGVPRKLYKPGLRNHRCACVRTTGPPSNQPSSAQNRGDLDNPTLQEYEGCHSLSDSCAIPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDC3</accession>
    <name>A0A401PDC3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004822">
        <property type="protein sequence ID" value="GCB71116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDC3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="96" mass="10380" checksum="0DC72ED0DC490B4F" modified="2019-05-08" version="1">MEHVRCRLAVQFTFSPALSKPGQRGQVKALQGYLHSGAARSVGEGVQEKPLHCRPSEGDLGCCPGPNSTAGEGLVSEQTDQMEEGRRKTWRQPGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDS8</accession>
    <name>A0A401PDS8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0005897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001906">
        <property type="protein sequence ID" value="GCB71277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDS8"/>
    <dbReference type="STRING" id="75743.A0A401PDS8"/>
    <dbReference type="OMA" id="PRSTNTN"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22139">
        <property type="entry name" value="F-box_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB71277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1229" mass="138138" checksum="7C626A276F8C660D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEB8</accession>
    <name>A0A401PEB8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myeloid-associated differentiation marker-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0005949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001937">
        <property type="protein sequence ID" value="GCB71466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEB8"/>
    <dbReference type="STRING" id="75743.A0A401PEB8"/>
    <dbReference type="OMA" id="TGGPYLN"/>
    <dbReference type="OrthoDB" id="8737882at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047123">
        <property type="entry name" value="MYADM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068:SF5">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="151"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB71466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="299" mass="32775" checksum="7368C8251859C6A6" modified="2019-05-08" version="1">MMEPGGPYLDSSALLSPLGVLRCLQALFGCITLSLVAHDGGFGAASGHFCMFAWGWCLALTALILSFEFTRLHSCLSISWDNFTIAFAMLATLMYVTATIIYPIYFVELECDQCQSRNFRISATSSSALACIAYAVEIHLTRAKPGQTGAYMATTSGLLKVVQAYVACILFGALLSGSEYSRYPATQWCVGVYSLCFIVTALVIALNVSGRAGLLRCPFDRVVVLYTFLATLLYLSAAVIWPVFCFDNKYGSMERPASCSLGDCAWDSQLIIAIFTYINLILYTVDLIYSQKIRYIAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEX8</accession>
    <name>A0A401PEX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E2 NEDD8-conjugating enzyme</fullName>
            <ecNumber evidence="14">2.3.2.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0001659</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the MRL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01000381">
        <property type="protein sequence ID" value="GCB71671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEX8"/>
    <dbReference type="STRING" id="75743.A0A401PEX8"/>
    <dbReference type="OMA" id="IRIAKXS"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16136">
        <property type="entry name" value="RA_MRL_Lpd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000033">
        <property type="entry name" value="NEDD8-conjugating enzyme UBE2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000048">
        <property type="entry name" value="Ras association (RalGDS/AF-6) and pleckstrin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000027">
        <property type="entry name" value="Ras association (RalGDS/AF-6) and pleckstrin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF15">
        <property type="entry name" value="RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="379"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="506"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="18">
        <location>
            <begin position="756"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="228"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB71671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="909" mass="103154" checksum="0DF64D279532DBF1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFH8</accession>
    <name>A0A401PFH8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0001732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000402">
        <property type="protein sequence ID" value="GCB71887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFH8"/>
    <dbReference type="STRING" id="75743.A0A401PFH8"/>
    <dbReference type="OMA" id="QHWPTSF"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="199"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB71887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="386" mass="42824" checksum="F3160C0DC60635F0" modified="2019-05-08" version="1">MAGVGDAGGLRRQRLLTHYDKSRNSYVEGIMEPQCKKRKTKAISTFTWELMPVLSDEELCEVELLEAYAAPIINKRQTSCLIKQLACIYPLNSLPHIKRVRTCRDKNTNHSLEIIICLLRDLNCTDVPNGEISLSDLFPDGKDIGIGLGEPFQVMIPACQPLTRPQFEAASQHWPTTFHENKQVTNALRGHLFNTEERAKVQTFMEKAIKAAKLGKEIGMEPVGAVVVNPATDEVIAVGHDCRNGPNPLLHAVMVCIDLVAYGQGGGAFNHDRYPNCHFKSEASFSGDHAFNTGKPLHPSEDHSPTGVPVNGLPYICTGYDLYVSREPCVMCAMALVHSRIRTVFYATSSPDGALGTKYKIHTKKDLNHHYDVFKGLLEGECQFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGV7</accession>
    <name>A0A401PGV7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002082">
        <property type="protein sequence ID" value="GCB72362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGV7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="11784" checksum="D7CE5C7B58133C24" modified="2019-05-08" version="1">MPEEWSQAFVTKEYEGQFSVANPPSLHIFGLWGRNPRKHGENVQTPHGQSTDGAHCGSSLVRRGTRHGDGVGGTLNDPGYTELNVTKIDASIVKPKLLRMTDSLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHW8</accession>
    <name>A0A401PHW8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">scyTo_0006447</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01002172">
        <property type="protein sequence ID" value="GCB72735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHW8"/>
    <dbReference type="STRING" id="75743.A0A401PHW8"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19402">
        <property type="entry name" value="TGF_beta_GDF9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000012">
        <property type="entry name" value="Growth/differentiation factor 9 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001332">
        <property type="entry name" value="Serine/threonine-protein kinase Nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019319862" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="26"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="23">
        <location>
            <begin position="274"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="444"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="778"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="857"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GCB72735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="944" mass="107788" checksum="B69A5D233773E4AD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHX6</accession>
    <name>A0A401PHX6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0002159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000523">
        <property type="protein sequence ID" value="GCB72743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHX6"/>
    <dbReference type="OrthoDB" id="9949564at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="262" mass="29848" checksum="5D24DD95E319C268" modified="2019-05-08" version="1">MCVAMCVALEIRTFIVHNQHLLPMKKQGTFWKAQALCCLCLVFLLPVAAAGKWCNNPDNFKWLRGKLQDEIDKLDDNLLPSMVKYSIFKDVNTAGLTYPCFIVVTAEQLNNTLLLLMSHFRANSYTYEQTQRVVKVLTNLYRECSDESSHRCVKPSTKAVTACRSDLFAYFRAVLNHYEYIFDQCHSVKETSKQSEGYCFFLEASNISVSSNCCLGTFSANRCLTNYQGGQERSYEPHQYLASVKQPVSAFLSMVLMDLEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK26</accession>
    <name>A0A401PK26_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000644">
        <property type="protein sequence ID" value="GCB73451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK26"/>
    <dbReference type="STRING" id="75743.A0A401PK26"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="16310" checksum="E0F93256366347B1" modified="2019-05-08" version="1">MNDRTEPRFVPFQNLNVTGFAKILKKYDKMFHATKGAGWQATQVEGSPVYTSKKIDQLITEVEGDIGVCVCQGDIGECVCVGVILECVCVSVSVILEYVCRCDIGVRVCRCDIGGDIGVCVSVRYWSMCVCRCDIGVCVCQCDVGVCVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKL5</accession>
    <name>A0A401PKL5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyl-CpG-binding domain protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methyl-CpG-binding protein MBD5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0002757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Core component of the polycomb repressive deubiquitinase (PR-DUB) complex, at least composed of BAP1, one of ASXL1, ASXL2 or (probably) ASXL3, and one of MBD5 or MBD6. Distinct combinations of ASXL and MBD proteins may preferentially bind specific histone modification marks. The PR-DUB core associates with a number of accessory proteins, including FOXK1, FOXK2, KDM1B, HCFC1 and OGT; KDM1B specifically associates with ASXL2 PR-DUB complexes. Interacts (via MBD domain) with ASXL1, ASXL2 and ASXL3 (via PHD domain); the interaction is probably direct, mediates association with other PR-DUB complex core components.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000709">
        <property type="protein sequence ID" value="GCB73677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PKL5"/>
    <dbReference type="OMA" id="MACVFQN"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000035">
        <property type="entry name" value="Methyl-CpG binding domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, DROSOPHILA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112:SF18">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MBD" evidence="12">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="11">
        <location>
            <begin position="1600"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="446"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1564"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1622"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1633"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1648"/>
            <end position="1659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB73677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1659" mass="176403" checksum="07A8F26F3AB8FEF4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PL09</accession>
    <name>A0A401PL09_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0002853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000735">
        <property type="protein sequence ID" value="GCB73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PL09"/>
    <dbReference type="STRING" id="75743.A0A401PL09"/>
    <dbReference type="OMA" id="EQGPHIY"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000025">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="243" mass="27356" checksum="95AEE907B8CDB886" modified="2019-05-08" version="1" fragment="single">MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKVLHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDIGPHIFQTCPSANYFDCKAMSIGARSQSARTYLERRMEEFQDCNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDIDFTIYDDDDVASFLEGLEERPQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLJ1</accession>
    <name>A0A401PLJ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0003051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01000802">
        <property type="protein sequence ID" value="GCB73968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLJ1"/>
    <dbReference type="STRING" id="75743.A0A401PLJ1"/>
    <dbReference type="OMA" id="CDPNKDM"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000293">
        <property type="entry name" value="SRSF protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000105">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF6">
        <property type="entry name" value="SRSF PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB73968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="569" mass="64252" checksum="EC1ED81012109CA2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLN3</accession>
    <name>A0A401PLN3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0003085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000815">
        <property type="protein sequence ID" value="GCB74001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLN3"/>
    <dbReference type="STRING" id="75743.A0A401PLN3"/>
    <dbReference type="OMA" id="MRSGSHP"/>
    <dbReference type="OrthoDB" id="9045962at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000095">
        <property type="entry name" value="Cadherin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000031">
        <property type="entry name" value="Cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF78">
        <property type="entry name" value="CADHERIN-LIKE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="95"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="215"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB74001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="646" mass="71861" checksum="D99ACBEA39ADC0D0" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PME1</accession>
    <name>A0A401PME1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0003389</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01000912">
        <property type="protein sequence ID" value="GCB74300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PME1"/>
    <dbReference type="STRING" id="75743.A0A401PME1"/>
    <dbReference type="OMA" id="YCEDAIR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000013">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000034">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF57">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="964"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1023"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="810"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="494"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="558"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="669"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="670"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="671"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="757"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="763"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="784"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="787"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="788"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB74300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130621" checksum="F13F0653F0A645F2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN37</accession>
    <name>A0A401PN37_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ST3 beta-galactoside alpha-2,3-sialyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0003651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001017">
        <property type="protein sequence ID" value="GCB74560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN37"/>
    <dbReference type="STRING" id="75743.A0A401PN37"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008373">
        <property type="term" value="F:sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF95">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE- ALPHA-2,3-SIALYLTRANSFERASE 4 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB74560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34617" checksum="C2B32C2EFF1EF244" modified="2019-05-08" version="1">MGFYFIIVAASGEISCKDVGTLLLLGWLISMKCRASWNKNKRLFRFVSVVLILLILTFHWNGFLWISLQLAKFHMKVSLPIQATQCSTWQSNNRSEQILPKFIRNTNLFLSIDGDWWKKPNYLFHTFPYGIKGNEVIVKKILVRTESHMPDEIDRLNCKRCVIIGNGNTLRNSSIGQTINEYDVVIRLNNAPVRGYEKDVGNKTTLRIFYPESATENTIAENNLDTLFVFVPFKTVDVRWLKAIVYNETKVGILDRNGNDSHGPHPETETFGITGVLLLCELMKWLRVASKYWCSKTLTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN95</accession>
    <name>A0A401PN95_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001025">
        <property type="protein sequence ID" value="GCB74583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN95"/>
    <dbReference type="OMA" id="ARHMSNK"/>
    <dbReference type="OrthoDB" id="9922947at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019137135" description="LRAT domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19391" checksum="EA47299C73F159DB" modified="2019-05-08" version="1" fragment="single">FCSSMLLVFLVVFCSDGVTMRSIRKHRRGNREVNNQHLPTYFQSVPQCSTMYNQYVVKAEKVVRPLKYLPWIMMGPLKHSGVRVTVAGGQKCLIHKGVEILARIGKSKTVVEDAKHLPFSWKVEEERPAYRRKMLEFIHACGEDYDVLTDNCHDCTERMMELTGASYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNW5</accession>
    <name>A0A401PNW5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001103">
        <property type="protein sequence ID" value="GCB74805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNW5"/>
    <dbReference type="OMA" id="LKHPPEA"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="385" mass="44889" checksum="75E007142EB0E02B" modified="2019-05-08" version="1">MYRYAFVMQRPLQSGMYRYAFAMQRPLQNGMYRYAFAKLRPSKAACIAMLSRCSAPAKRHVSLCFRDATPPPKRRVSLCFREAPPLQSGMYRYAFAMLHPLQSGMYRYAIAVLRPCKAACIAMLSLCSTTAKRRVSLCFRDATPPPKRHVSLCFRDAPPLQSGMYRYAFAKLSPLKSSVFRIPFAKLRPLQSGVYRYAFAKLRPLQSGVYRYAFVKLRPLQSGMYRYAFAMQRPLQSGMYRYAFAMQRPLQSDMYRYAFAMQRPLQSGVYRYAFTKLHPLQSGVYRYAFAKLCPLQSGMYRYVFAKLHPLQSGMYRYAFAMQRPLQSGVYRYAFAKLHPLQSGVYRYVFAMLRPLQSDMYRFAFAMQHPLQSGMYRYAFAMLHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPA2</accession>
    <name>A0A401PPA2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014910">
        <property type="protein sequence ID" value="GCB74957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPA2"/>
    <dbReference type="STRING" id="75743.A0A401PPA2"/>
    <dbReference type="OMA" id="RIAYHNY"/>
    <dbReference type="OrthoDB" id="6136870at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019122356" evidence="1">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="324" mass="31754" checksum="EA605A53146569C9" modified="2019-05-08" version="1">MFSQWLEMWLVTLSHCFAAGDVVSLVSDIAGDVSPVTDFVGDVVTLLGNAAVDVVSLVSDAVGDIVSLVSDAPGDVVSLVSDDAGDVLSLVSDVADHVVTLISDVAGDVDSLVNDVAGDVVTLVSDVAGDVVSLVSDVAGDVVSQVSDVAGDVGSLVSDVAGVVGSLVSDVAGDVGSQVTDVAGDVGSLVSDVAGVVVSLVSNVVGDVTLVIDVAGDVFHCDVTGDVVSLVSDVVGDVVSLVSDVVGDVVSLVSDDADDVSLVSDAVGDVVSDVAGDVVTLVRDVAGDVVSLVSDVAGDIVSLVSDAVGDVVSLVSDAAGEVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQK4</accession>
    <name>A0A401PQK4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011185">
        <property type="protein sequence ID" value="GCB75408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQK4"/>
    <dbReference type="STRING" id="75743.A0A401PQK4"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB75408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11034" checksum="6C43CB7018A7C542" modified="2019-05-08" version="1">MTAKHMEKSCDVLPKEDSEGLGEYLPYVLVKHLQFCGYDLEINQYMNYKMGVSALIWECAFVLCQYFQQEKMNFSGKKVIELGSGTGIVGILAVLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQW4</accession>
    <name>A0A401PQW4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0020924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017656">
        <property type="protein sequence ID" value="GCB75519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQW4"/>
    <dbReference type="STRING" id="75743.A0A401PQW4"/>
    <dbReference type="OMA" id="HEIDAKC"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16860">
        <property type="entry name" value="ING_ING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15584">
        <property type="entry name" value="PHD_ING1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000021">
        <property type="entry name" value="Inhibitor of growth 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028643">
        <property type="entry name" value="ING1_PHD_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF85">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB75519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="276" mass="32200" checksum="B2048B3B00138793" modified="2019-05-08" version="1">MLSPANGEQLHLVSYVEDYLDSIESLPFDLQRNVSLMREIDAKYQDILKELDEYYEKHKRETDVVQRRRILHYIQRALIRSQELGDEKIQIVNQMVELVENRSRQVESHVELFENCAESNDSNNKSSLERSRSEGTTPVEKPSAKRSRRQRNNENRENTSSNHDHEESSAGMPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNEECPIEWFHFSCVSLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRT8</accession>
    <name>A0A401PRT8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GRHL1/CP2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017722">
        <property type="protein sequence ID" value="GCB75820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRT8"/>
    <dbReference type="STRING" id="75743.A0A401PRT8"/>
    <dbReference type="OMA" id="EACFIIC"/>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRHL1/CP2 C-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="112" mass="12737" checksum="9E4BDABED18EF1B9" modified="2019-05-08" version="1" fragment="single">SVHPKLAIYVCQETEQNQENHQRKRESIEGVGSSCVYHAIFLEELTAIKLTEKIANLYSISPQQINQIYRQGPSGIHVLVSDEMVKNFHDEACFIICTSKAERSDGYNIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTA9</accession>
    <name>A0A401PTA9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017458</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01011362">
        <property type="protein sequence ID" value="GCB76374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTA9"/>
    <dbReference type="STRING" id="75743.A0A401PTA9"/>
    <dbReference type="OMA" id="CSGGRNE"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14340">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048622">
        <property type="entry name" value="BRSK1_2-like_UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21122">
        <property type="entry name" value="KA1_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21115">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRSK1/2-like UBA" evidence="12">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB76374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="329" mass="36814" checksum="7D5DB91425608D0E" modified="2019-05-08" version="1" fragment="single">MPARMEPRESRGLEQIQKHTWYQGGKNEPEPEQPIARKVMIRRLQSVSDIDPDVLDSMNSLGCFRDKNKLKHDLMFEEENQEKMIYFLLLDRKERYPSCEDEDLPPRNDIVYPSDILVFSCARSRSVSGASCGLSSSPLSSPRVTPHPSPRGSPLPTPLGTPVHTPKESPTSTPNATPPSSPGVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTEEMSSLTPESSPELAKKSWFGNFINLDKEEQIFVVIRDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKSVGGPTVFQKPVKFQVDITYAEGSEAQKENGIYSVTFTLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU08</accession>
    <name>A0A401PU08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013993">
        <property type="protein sequence ID" value="GCB76611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU08"/>
    <dbReference type="STRING" id="75743.A0A401PU08"/>
    <dbReference type="OMA" id="DVFTWQM"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="17822" checksum="50CB2A459F475BFD" modified="2019-05-08" version="1">MGQPGEQKVDIYRDTWVRFLGYANEVGEAFRALVPVGFVWASYGISTAYVTADAVDKGKKAAAAHGDKPGKSMSVGIAVVDTFIWQSLASVIIPGFTINRLCAASLLLLRKTTRWPLPMRKWTTTAIGLSAIPVIITPIDRSVDFLLDATLRKLYGAEEKHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV28</accession>
    <name>A0A401PV28_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015394">
        <property type="protein sequence ID" value="GCB76952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV28"/>
    <dbReference type="STRING" id="75743.A0A401PV28"/>
    <dbReference type="OMA" id="DMIQGHE"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23069">
        <property type="entry name" value="PDZ_ARHGEF11-12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000033">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF3">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="333" mass="36678" checksum="23330A619A1272DE" modified="2019-05-08" version="1" fragment="single">FPIRRLPRQGGSNLNKDLSPDKHDKKNSEKSPLYEFDPTGLVQRCVIIQRDENGFGLTVSGDNPVFVQSVKEDGAAVRAGVQQGDRIIKVNGSLVTHSNHVEVVRLIKSGSYVALTVLGRPPGSPQIPLTATDGDPGTFFFPGQQGAISPNPTFSPHSPSSSCPDRITSPMPVTEDNIVHSQKVEILRNMLGTEIRQLEQLKEKYMRNPSQQLLRDQQEVEKHIHQLQEQLSKATGSSSQDSSNFVRLSETLTIVERLTEDGDWEHEPQPQGESMGSDKCRVSFSRTESTITSPSTPSDGHFHRTSLSNSSAKDAGSVSESMDIDESQDWVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVW2</accession>
    <name>A0A401PVW2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Glutamine synthetase</fullName>
            <ecNumber evidence="6 17">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0018445</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15 16">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="6 17"/>
    <dbReference type="EMBL" id="BFAA01012848">
        <property type="protein sequence ID" value="GCB77232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVW2"/>
    <dbReference type="STRING" id="75743.A0A401PVW2"/>
    <dbReference type="OMA" id="IFLKPVC"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000011">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF45">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="18">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="19">
        <location>
            <begin position="158"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB77232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="419" mass="47389" checksum="1B89F4A1413467F4" modified="2019-05-08" version="1" fragment="single">EIREEALGQQVCFWRRMRISRCFLFLVKKCGNIKPANWRNQHTYKMATSASANLSKIVKKNYMELPQDGKVQAMYIWIDGTGESVRCKTRTLDKEPKAVSDLPEWNFDGSSTYQSEGSNSDMYLIPSAMFRDPFRKDPNKLILCEVLKYNRKPAESNLRNSCQKIMAMVSDEHPWFGMEQEYTLLGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGIHLSGTNAEVMASQWEYQVGPCEGIHMGDHLWMSRFILHRVCEDFGIIASFDPKPIPGNWNGAGCHTNFSTKSMRDEGGLKFIEECIEKLGKRHQYHIRAYDPKGGLDNARRLTGHHETSNINEFSAGVANRGASIRIPRSVGQEKKGYFEDRRPSANCDPYAVTEALIRTCLLGEAGDKPIENNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWC6</accession>
    <name>A0A401PWC6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Transcription factor E4F1</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Putative E3 ubiquitin-protein ligase E4F1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">RING-type E3 ubiquitin transferase E4F1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Transcription factor E4F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">scyTo_0015665</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01008983">
        <property type="protein sequence ID" value="GCB77431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWC6"/>
    <dbReference type="STRING" id="75743.A0A401PWC6"/>
    <dbReference type="OMA" id="SAMCARR"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001557">
        <property type="entry name" value="Transcription factor E4F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000086">
        <property type="entry name" value="transcription factor E4F1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002233">
        <property type="entry name" value="transcription factor E4F1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000875">
        <property type="entry name" value="zinc finger protein 236 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="21" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0498">Mitosis</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 26" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="28">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00067631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00075006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="GCB77431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="752" mass="83843" checksum="C48D6023E023F164" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWE5</accession>
    <name>A0A401PWE5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coenzyme PQQ synthesis protein F-like C-terminal lobe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0019996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015511">
        <property type="protein sequence ID" value="GCB77450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PWE5"/>
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    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="2">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="174" mass="20015" checksum="E193A0E32E3DFDB4" modified="2019-05-08" version="1" fragment="single">LLIAFKILNSTELVDQKIEEFLNSFYTKLTTMTQEAFSTQVTALIKLKLCEDTHLGEEVDRNWDEVLTQQYLFDRLTHEIQALKSFTQPDLIDWFQAHQGHTSKKLSIHVIGQGQQEPDATPEDATCDSKFMHGEACQLIFVPVSPQMEHIIPINDIAAFTSHLKLYPYHKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWI2</accession>
    <name>A0A401PWI2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016823">
        <property type="protein sequence ID" value="GCB77468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWI2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="8185" checksum="79641AC6D79EFB61" modified="2019-05-08" version="1">MVPQSVTSDLRSVQIDTGHDTPLARENQSIFLRQFRKTSSVLLWRQKWPKTLKSPNYPSPRRTENSRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX58</accession>
    <name>A0A401PX58_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retinoblastoma-associated protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009029">
        <property type="protein sequence ID" value="GCB77702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX58"/>
    <dbReference type="STRING" id="75743.A0A401PX58"/>
    <dbReference type="OMA" id="MEFLCKE"/>
    <dbReference type="OrthoDB" id="844594at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035189">
        <property type="term" value="C:Rb-E2F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048667">
        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.140:FF:000002">
        <property type="entry name" value="RB transcriptional corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF36">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01367">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="383" mass="43666" checksum="618F507843C4E08B" modified="2019-05-08" version="1" fragment="single">MPPKPPRRAAAGVAEESVSPGRHDNKDADFVLLCQSLKVGENVNERAWKIWESVSEVYNDGTILDAIRKYWGICIFIAAVDLNAVSFTLTELLKTLDLNVTEFLQLLKKMDVNLDTVSTKVNSVVLKLEKKYLVFTALFEKFKRICEEIFVEAPSFQASSETNKPVAKLCWITFLLATGKLLQMEDDLVLSFQLLLCVLEYFIKISPSAMIKEPYRSTANSINSSGPSRSSRRSQNRVIQTSNSTEVDLRVMEILCQENECNVEEVKNIYLKSFLPFLDNLKIPSSSGFPEIESLSRQYEELYHKNKDFDARLFLEHDKTLQLDPEERYDLESTPRKPHAEDGHTVIPPQTPVRTAMNTIQQLQMILNTADDKPSNTLEAYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX87</accession>
    <name>A0A401PX87_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TRAF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015579">
        <property type="protein sequence ID" value="GCB77718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX87"/>
    <dbReference type="STRING" id="75743.A0A401PX87"/>
    <dbReference type="OrthoDB" id="1737200at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000323">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB77718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="196" mass="22038" checksum="5F2A548E1A99967D" modified="2019-05-08" version="1" fragment="single">AHLKTCPFQHVQCTRSSCSELVRRRDLSDHLTNKCKHREVKCKYCQKDTTLAQLQTHKANECPYSLIASPKTCGAHVHKPELSALEFHLKSHLQTILRGDRQQSTLALNMTIRPSACGAVHVPALQLHRSLCRPDTGARFDVVHAGQLYSHRRPAPGRPVSGLSNRLFSDHPEDIRHVRLKPAGTTEQIQRTVAHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0F8</accession>
    <name>A0A401Q0F8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PI4-kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009229">
        <property type="protein sequence ID" value="GCB78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0F8"/>
    <dbReference type="STRING" id="75743.A0A401Q0F8"/>
    <dbReference type="OMA" id="IAKYYRI"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI4-kinase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PI4-kinase N-terminal" evidence="2">
        <location>
            <begin position="398"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="844" mass="95702" checksum="0C05C7A8F5E367AA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0L3</accession>
    <name>A0A401Q0L3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0020731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017193">
        <property type="protein sequence ID" value="GCB78959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0L3"/>
    <dbReference type="STRING" id="75743.A0A401Q0L3"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="13018" checksum="D25FA2C46FA4A0FE" modified="2019-05-08" version="1" fragment="single">VYNKDFCETFTVLNLDLKLVKSIIFNPEIDELITGGVGGVKFWKYKMNQKSNSKVVAMSNYELYLRADYPHMGGNWVTKVELDVATQQVFCCSVQALFCYDTEGKLLLEIPNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3I5</accession>
    <name>A0A401Q3I5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012149">
        <property type="protein sequence ID" value="GCB79987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3I5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="392" mass="42826" checksum="D93FAD23C7628257" modified="2019-05-08" version="1" fragment="single">LEVTSEGKTNENGIQKNVALEYTSQTQVPDARRSRLQNKNFPLYLKSKHHLSHISDSQPTSILNPSNGKGMEKTPNAHKSTGKELTSSAVQDTKLHMQGGTQSPVKQHDNHSPATVSPDGMSWAYPQCLDEPKDEEMSQPEEGETSIVSSSASQLSAASPSASQNLHSDKSHSPAPSELQSHQTSSLESKHLDVCPSPEQSSVKDSCLLEQVLGKEPIAKALCDLQVDIANFLTPSADFLEQILDNVPTDVTAAVTDENTCQQRETDASLLALSTTFGLLVDEGMNLLSKTMDNVHSSVQSGNKQMHTDMIHLHNVIHMGWVQLAEQMSSLIKVLTTLVHNQQPSSTLLHNVALQRTIAISEGHFADYLRCESTPRELRGDPSSLVHFQETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q465</accession>
    <name>A0A401Q465_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010825">
        <property type="protein sequence ID" value="GCB80168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q465"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10132" checksum="E450631B8A89A703" modified="2019-05-08" version="1">MILQLTPVLGELTLFSKSCLFMRNGMCLSSLAGRVTILRSRLGFHQTPLSDEKLSITRIIRKEDLLLLMWKDKSVLGQLLFYPGPLPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4I6</accession>
    <name>A0A401Q4I6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomal protein kizuna</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polo-like kinase 1 substrate 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0018060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kizuna family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012246">
        <property type="protein sequence ID" value="GCB80279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4I6"/>
    <dbReference type="OrthoDB" id="8015657at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026742">
        <property type="entry name" value="Centrosomal_kizuma"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16299">
        <property type="entry name" value="CENTROSOMAL PROTEIN KIZUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16299:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN KIZUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB80279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10393" checksum="3E9C000B01922D12" modified="2019-05-08" version="1">MHQKNHDWLQSAQWCVGIQIVGEYEDMLLKLNAAFFNFNRDRNKKERINPAQSKAFWGESDDSASDIEAILHPQTSEALEDNDDFNDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5E4</accession>
    <name>A0A401Q5E4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-responsive element-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0016272</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009735">
        <property type="protein sequence ID" value="GCB80599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5E4"/>
    <dbReference type="STRING" id="75743.A0A401Q5E4"/>
    <dbReference type="OMA" id="GHEQYTI"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030350">
        <property type="term" value="F:iron-responsive element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000011">
        <property type="entry name" value="Iron-responsive element binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000012">
        <property type="entry name" value="Iron-responsive element binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000005">
        <property type="entry name" value="Iron-responsive element-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
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    <sequence length="1001" mass="109764" checksum="54B681B9ADACB6E2" modified="2019-05-08" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    <sequence length="150" mass="16587" checksum="947642E5ABB5BB80" modified="2019-05-08" version="1">MNSVPSGEGNRSLSGNWLIQINYRETLTVNDEAATSEFDGSLHILWTETGRKNPTHQWHKCTNSADEVHLLPHWPRRLSETNVGCGLGTVSREQRAVVIDTCDKAVRLVNPHEPALCPASHNDCKASDATFYTTLELIHGVLLQSSGEVK</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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</entry>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
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                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="OMA" id="ERPVCKS"/>
    <dbReference type="OrthoDB" id="5974632at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="136"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="154" mass="17559" checksum="8A37D0A7D1A13FA8" modified="2019-05-08" version="1">MAKQLPHSQTEPARSWTSSTPSVQWPREHQLYRSFASETQVSVIHPPKLIPAQDLIAFEQGQLCSSGQPSGRQQPEAFRLLKVNIQPFESRNKCDSKKRLKRRRERRVTERPVCKSPQSDKQLASPDPPEHQEVESRTCVVKSLGLCSEMSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7S2</accession>
    <name>A0A401Q7S2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021502">
        <property type="protein sequence ID" value="GCB81422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7S2"/>
    <dbReference type="STRING" id="75743.A0A401Q7S2"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8925" checksum="F8C5084F1C304122" modified="2019-05-08" version="1" fragment="single">AMKRIYKACLKYPEWKQKHNPHFKPWVYPEQNTLPRVSLSDLSLQNASSLENIDESSLSEEKVHISDEEESYSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QA53</accession>
    <name>A0A401QA53_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0021571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019369">
        <property type="protein sequence ID" value="GCB82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QA53"/>
    <dbReference type="STRING" id="75743.A0A401QA53"/>
    <dbReference type="OMA" id="GYEWELI"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF177">
        <property type="entry name" value="CYTOCHROME P450 26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="10 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="277" mass="31195" checksum="136FA379133CA4BB" modified="2019-05-08" version="1" fragment="single">QGMQARDNLHKYLEKAISEKLQCKQDKDYSDALDILIDSAREHGKELTMQELKESTVELIFAAFATTSSATTSLILQLLQHPAVLEKLREELRHHGILHNGCKCEETPRMDTVVRLKYLDCVIKEVLRLLPPVSGGYRTALQTFELDGCQIPKGWSVLYSIRDTHDTSPVFQNVEVFDPDRFGEDRDENKGDRFSYIPFGGGIRSCLGRELAKLILKVLAMELASTSRFELATRTFPRMLTVPVVHPVDGLKVKFSGLDANQNEIDPETESMLGSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QA56</accession>
    <name>A0A401QA56_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0022641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023335">
        <property type="protein sequence ID" value="GCB82269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QA56"/>
    <dbReference type="STRING" id="75743.A0A401QA56"/>
    <dbReference type="OMA" id="MARDSYT"/>
    <dbReference type="OrthoDB" id="6491773at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000094">
        <property type="entry name" value="protocadherin gamma-C4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF133">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="138"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB82269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="239" mass="26437" checksum="E6CA014733C3B69D" modified="2019-05-08" version="1" fragment="single">IVANDTTNPTECCSSATLIIYIVDINDHSPEFPQQAYILSVKEHANIGTKIATVRATDPDSGSFGRITYSLLPKSIRNDFKVNSTTGVITVENNITLDREKRPIYYATLQATDGGNRIGTTALEIVLEDINDFHPVMARDSYTAFITENKDNELNIRIEAFDNDQEGTNNSEIRYTIAAGDYRQNFTIDPITGVLRSVGPIDREDMKSSLNGKIILIVEAYDLGIPKLSTTVNVTINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAS5</accession>
    <name>A0A401QAS5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0023083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026078">
        <property type="protein sequence ID" value="GCB82456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAS5"/>
    <dbReference type="OMA" id="MYENESV"/>
    <dbReference type="OrthoDB" id="75908at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053901">
        <property type="entry name" value="C5orf34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053899">
        <property type="entry name" value="C5orf34-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027830">
        <property type="entry name" value="C5orf34-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34531:SF1">
        <property type="entry name" value="CHROMOSOME 5 OPEN READING FRAME 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34531">
        <property type="entry name" value="ZGC:153352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15025">
        <property type="entry name" value="C5orf34-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22833">
        <property type="entry name" value="C5orf34_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019060053" evidence="2">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C5orf34-like N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C5orf34-like second" evidence="4">
        <location>
            <begin position="133"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB82456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="321" mass="35428" checksum="BB843F495D519BA2" modified="2019-05-08" version="1" fragment="single">APLVTVHLLELATMALVSLMVLYEDDSVEMQFTDGSSLQLSPCGSEFLFEKAPAPTMHPLHGSCRVRQRTSFVISTYKEQLLQALEFRNRFTSRPYLAADLIAAGKLSNMFFDISEVKWPGTVTEDALKIADSGRVTVSSLGGHAFLYLAPSRLEFTVEFLACVNQSPVSKRLIKAGRGWNSGPQQPLCHNLNKIKPVGFGVDRGGSGRKVQSSQSKSNGASYPLMLELRDGDSIRCKYIYQYTWVVQHHTVSSCPPEWHCPLKLALHHDCKQEKSRLDGAHNHRQSADKPLAPGVDVTQGTATALPKVLPLNCPAPHLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCG0</accession>
    <name>A0A401QCG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Band 3 cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030229">
        <property type="protein sequence ID" value="GCB83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCG0"/>
    <dbReference type="STRING" id="75743.A0A401QCG0"/>
    <dbReference type="OMA" id="CITSAVN"/>
    <dbReference type="OrthoDB" id="8946271at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015701">
        <property type="term" value="P:bicarbonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF47">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="1">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="151" mass="17587" checksum="F089410973F0927E" modified="2019-05-08" version="1" fragment="single">HRFEDVPGVRRHLVKRSTKGTVVHVGKDHSEPFPKAKKADRKPHEVFVELNELTVDKNHEMQWKETARWIKFEEDVEEETDRWGKPHVASLSFRSLLELRKTLAHGTVLLDLDQRSLPGIAHQVVEQMIISDQIKAEDRANVLRALLLKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEK7</accession>
    <name>A0A401QEK7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01044641">
        <property type="protein sequence ID" value="GCB83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEK7"/>
    <dbReference type="OrthoDB" id="10552642at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="761" mass="80739" checksum="F6944849054BF5B4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF17</accession>
    <name>A0A401QF17_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mannose-1-phosphate guanyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01052692">
        <property type="protein sequence ID" value="GCB83966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF17"/>
    <dbReference type="STRING" id="75743.A0A401QF17"/>
    <dbReference type="OMA" id="EIAHFGR"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480:SF1">
        <property type="entry name" value="ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="173" mass="17590" checksum="56F17EBD3E89EF76" modified="2019-05-08" version="1" fragment="single">VDDAEIGDDAEIGDDAEIGDDAEMGVDARVDDAVIVDDTELGDDAEIGDDAEIGDGAEIGDDAEIGDDAEIGGDAEIGDDAEIVDDAEIGDDAEILDAAEIGDDAVIVDDAVIGDDVEIGDDAEIGDDAEIGDDTEIGDDTEIEDDAEIGDDAEIGDDAEMGVDAVIVDDAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFG2</accession>
    <name>A0A401QFG2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01050549">
        <property type="protein sequence ID" value="GCB84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFG2"/>
    <dbReference type="STRING" id="75743.A0A401QFG2"/>
    <dbReference type="OMA" id="NDAMCPL"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="18870" checksum="CE16C48BD9055657" modified="2019-05-08" version="1">MGREQDHRKREQEHREREQEHAESEQEHGESEQEQREREQEHSEREQVHGEGEQEHGVREQEHRKGEQEHREREQEHGEREQAQRESEQEHGEREQEHREREQQNREREQEHGEREQEHGDREQEHRVREQEHTEREQEHRERAQDHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIG7</accession>
    <name>A0A401QIG7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0025847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01133056">
        <property type="protein sequence ID" value="GCB85189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIG7"/>
    <dbReference type="STRING" id="75743.A0A401QIG7"/>
    <dbReference type="OMA" id="PPLEQYR"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000251">
        <property type="entry name" value="FEZ family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000164">
        <property type="entry name" value="Fez family zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB85189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="306" mass="33537" checksum="8E177F43CB6933F8" modified="2019-05-08" version="1" fragment="single">MDNTYSHRCRAERLLGATSAGRESLQAGDGMISTSKPLAFSIERIMARTPEPKCAPYPNLLQGTVIKGEAKHVLHLNSSVPCMIPLLPLGYDSSSKVAPSGAELRKSHYDCARLVPSKADACSLSPPLEQYRLIRPRVVNQSSFHAMGALCYLNCGERPCAPPAAATIFNVHPMASYLLGSPLQALQQKAFLADRSKVVLQPSLERYPAAFKELSPAQIQHYVKESAQFLSEKLALKQSCKVSSHPPSSKPKVFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ18</accession>
    <name>A0A401QJ18_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01148791">
        <property type="protein sequence ID" value="GCB85375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ18"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8973" checksum="3A0A3A7AAFA6A2F6" modified="2019-05-08" version="1">MPVETGRAGIPVEQEEQGTLWRQEGQESLGRQKEQESLMSKEEQETLWRQEELESLWRQEELESLLRQEEQGSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLA1</accession>
    <name>A0A401QLA1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01243630">
        <property type="protein sequence ID" value="GCB86093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLA1"/>
    <dbReference type="STRING" id="75743.A0A401QLA1"/>
    <dbReference type="OMA" id="QANTKQC"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="278" mass="31251" checksum="6124953E22FB53BD" modified="2019-05-08" version="1" fragment="single">ANTKQRSPEVPQANTKQRSPDVTQANRKQRSPEVPQANRKQSSPEVPDANTKQRSPEVREADTKQRSPEVPEVNTKQRSSKVPQANTKQCSPEVPEVNTKQRSSKVPQANTKQRSPEVPQANTKQRLPEIPEANTKQRSPAVPEANMKQRSPEVPQANTKQRSPEVPEANTKQRSPAMPEANTKQRSPEVPEANNKQRWPEVPQANTKQCSPEVPEANTKQRSPEVPEANMKQRSPEVPQANMKQRSPEVPQVNTKQRSHEVTQANMKQCSPEVPERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNH0</accession>
    <name>A0A401QNH0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01370885">
        <property type="protein sequence ID" value="GCB86950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNH0"/>
    <dbReference type="STRING" id="75743.A0A401QNH0"/>
    <dbReference type="OMA" id="DALICTI"/>
    <dbReference type="OrthoDB" id="9942939at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16618" checksum="A747562D39B6B7A9" modified="2019-05-08" version="1" fragment="single">PEALIYTIPEALIYTIPEALIYNIPEALTYTIAEALIYTIPEALIYTIPEALIHTIPDALICTIPEAQIYTIREALTYTIPEALTYTIPEALIYTIPEALIYTIPEALAYTIPEALIYTIPESLIYTIPEALIYTIPVALIYTIPEALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNK2</accession>
    <name>A0A401QNK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01372269">
        <property type="protein sequence ID" value="GCB86955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNK2"/>
    <dbReference type="STRING" id="75743.A0A401QNK2"/>
    <dbReference type="OMA" id="TWGPERV"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="14634" checksum="EF668044EB8C8FF8" modified="2019-05-08" version="1" fragment="single">MEFQIAEEDPQTFPISVTWGPERVRNVRSKWEKVMTGNGLQLPNGLQLLYGLQLPNGLQLLNGLQLLNGLQLQNGLQLLNGLQLPNGLQLPNGLQLPNGLQLPYGLQLLNGLQLPNGLQLLYGLQLPNGLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNY1</accession>
    <name>A0A401QNY1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 90</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0027675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01382167">
        <property type="protein sequence ID" value="GCB87003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNY1"/>
    <dbReference type="STRING" id="75743.A0A401QNY1"/>
    <dbReference type="OMA" id="AISENNH"/>
    <dbReference type="OrthoDB" id="7977805at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB87003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24633" checksum="77C1C0D2D95A929F" modified="2019-05-08" version="1" fragment="single">VLTKHNDDEAYAWESLAGGSFTVKTYTGKGDGEYSADAVIRGTKVVLHLKEDQAESQDEGEKTKIEEVGSDEEGDGEKKDKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFCALLFIPRRAPFENKKKKNNIKLYVRRVFIMDSCKELILEYLNFVRGVVDSEDLPLNISREMLQQSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NFS9</accession>
    <name>A0A401NFS9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007388">
        <property type="protein sequence ID" value="GCB59813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NFS9"/>
    <dbReference type="OrthoDB" id="10232574at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB59813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="222" mass="22426" checksum="AE2CBC968C4CD9F0" modified="2019-05-08" version="1">MFDPPTALDPVWSDPPTALDQVMSGPPTELDPVLSDPPAAPDLVMSGPPTALDPVLSDPPTALDPVLSDPPTALDAVLSDPPTALDAVLSDPPTALDPVMSDPPTTLDAVLSDPPTALEPVLSDPPTALDAVLSDPSTALDPVMSDPPTTLDAVLSDPPTALDPVLSDPPTALDPVLSDPPKALDPVLSDPPTALDPVLSDPPTELDPVLSGSTCSTGSSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH99</accession>
    <name>A0A401NH99_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0014132</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Inflammasome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NLRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007475">
        <property type="protein sequence ID" value="GCB60246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH99"/>
    <dbReference type="STRING" id="75743.A0A401NH99"/>
    <dbReference type="OMA" id="SIQQEWA"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14" id="KW-1271">Inflammasome</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019248067" description="NACHT domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="32"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="18">
        <location>
            <begin position="277"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB60246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="108581" checksum="302780DA711905A7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHG2</accession>
    <name>A0A401NHG2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0011114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the ER membrane protein complex (EMC). EMC8 and EMC9 are mutually exclusive subunits of the EMC complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004941">
        <property type="protein sequence ID" value="GCB60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHG2"/>
    <dbReference type="STRING" id="75743.A0A401NHG2"/>
    <dbReference type="OMA" id="PHCAING"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF13">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="201" mass="23142" checksum="D2D6CD703CD3138A" modified="2019-05-08" version="1">MTLFRLTTQAYCKMLLHAAKYPHCAVNGILVAEKHKRKDGQPVLFVDCVPLFHGTLALAPMLEVALTLVDSWCKENNYIIAGYYQANERMKDTSPNQVAEKVASRIAENFSDAALIMVDNHKLTMECEEQSIVVYEHHENKWRCKDPNTDFCEDWSEVQRITTCLLDGKFYDSLVDFDNHMDDLRNDWTNPEVNKAVLHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI33</accession>
    <name>A0A401NI33_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Stannin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0003957</name>
        <name evidence="17" type="ORF">scyTo_0027179</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the stannin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001126">
        <property type="protein sequence ID" value="GCB60529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAA01297565">
        <property type="protein sequence ID" value="GCB86442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI33"/>
    <dbReference type="STRING" id="75743.A0A401NI33"/>
    <dbReference type="OMA" id="PCMERKA"/>
    <dbReference type="OrthoDB" id="9448252at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20257">
        <property type="entry name" value="Stannin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.20:FF:000001">
        <property type="entry name" value="stannin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.20">
        <property type="entry name" value="membrane protein stannin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015137">
        <property type="entry name" value="SNN_cytoplasm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015136">
        <property type="entry name" value="SNN_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015135">
        <property type="entry name" value="SNN_transmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038747">
        <property type="entry name" value="Stannin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027435">
        <property type="entry name" value="Stannin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28564">
        <property type="entry name" value="STANNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28564:SF1">
        <property type="entry name" value="STANNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09051">
        <property type="entry name" value="SNN_cytoplasm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09050">
        <property type="entry name" value="SNN_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09049">
        <property type="entry name" value="SNN_transmemb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Stannin transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Stannin unstructured linker" evidence="14">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Stannin cytoplasmic" evidence="15">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB60529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB86442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9007" checksum="C54F73DE526690F8" modified="2019-05-08" version="1">MDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRIGQSEDEESIVGEGETKEPFLLVQYSAKGPRVERKAKLTANGTEGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI72</accession>
    <name>A0A401NI72_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein brambleberry</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007526">
        <property type="protein sequence ID" value="GCB60564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI72"/>
    <dbReference type="STRING" id="75743.A0A401NI72"/>
    <dbReference type="OMA" id="DHSMSEF"/>
    <dbReference type="OrthoDB" id="5978806at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040346">
        <property type="entry name" value="GEX1/Brambleberry"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538:SF1">
        <property type="entry name" value="PROTEIN BRAMBLEBERRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019469025" description="Protein brambleberry" evidence="2">
        <location>
            <begin position="28"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB60564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="69731" checksum="049EDE27CAC163A2" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM18</accession>
    <name>A0A401NM18_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Single Ig IL-1-related receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0012989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006466">
        <property type="protein sequence ID" value="GCB61900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM18"/>
    <dbReference type="STRING" id="75743.A0A401NM18"/>
    <dbReference type="OMA" id="WCTNNFR"/>
    <dbReference type="OrthoDB" id="6075577at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF19">
        <property type="entry name" value="SINGLE IG IL-1-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019183360" description="Single Ig IL-1-related receptor" evidence="7">
        <location>
            <begin position="33"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="43"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="159"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="8">
        <location>
            <begin position="314"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB61900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="65077" checksum="047270E29FCC11E1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMM2</accession>
    <name>A0A401NMM2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0007167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002549">
        <property type="protein sequence ID" value="GCB62126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMM2"/>
    <dbReference type="STRING" id="75743.A0A401NMM2"/>
    <dbReference type="OMA" id="VCNDEIY"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000048">
        <property type="entry name" value="Glycosyltransferase 25 family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF8">
        <property type="entry name" value="PROCOLLAGEN GALACTOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB62126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36100" checksum="BE8E91B01D5C0CEE" modified="2019-05-08" version="1">MEKKSPAKDKEDNYQADVNMVLKNDSNSSTGRNIEVTLPACSHSEANAGSIEDRPLICLLLLSLTAIAGHGAHFPEETLAKESALLRPKVLLAIIARNAAHTLPHYLGCIERLDYPKDRIALWVATDHNTDNTTAILREWLKNVQKAYHYVEWRPLDHPKHYSDEIGPKHWSNSRFSHVMKLKQTALKTAREKWADYILFVDTDNVLTNEQTLNLMIAENLTVVAPMLDSHTLYSNFWCGMTPQGYYRRTPDYIPIREWKRTACYPVPMVHSTFLIDLRREATRKLAFYPPHPDYTWAFDDIIVFAFSCKVAGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN24</accession>
    <name>A0A401NN24_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0011439</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005203">
        <property type="protein sequence ID" value="GCB62270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN24"/>
    <dbReference type="STRING" id="75743.A0A401NN24"/>
    <dbReference type="OMA" id="CDIPPAW"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000089">
        <property type="entry name" value="5-hydroxytryptamine receptor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002231">
        <property type="entry name" value="5HT_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01101">
        <property type="entry name" value="5HTRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="343" mass="39008" checksum="3E96F97828AA70E5" modified="2019-05-08" version="1">MYINGSLLLNGSSGESRLKGQSFAVFRILVVCLLTLLILATFVWNFLVLVTILRVKTFHRVPHNLVASMAVSDVMVAALVMPLSLVNELFGRRWRLGRVLCHIWISFDVLCCTASIWNVTAIALDRFWSITRHLEYTLDTRKRISNVLIALTWALSAVIAFSPLFGWGEAYSAATQNCQVSQEPSYTIFSTCGAFYLPLSVVLFVYWKIYKAAKFRIGSRKRNVVVPMPEILQVKEASHQPQMECAVRHAALTFQADGEAWRQQKEKKAAVMVGILIGVFVLCWIPFFITELISSLCSCDIPPTWKSIFVWLGYSNSFFNPLIYTAFNKNYNNAFRCLFIKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNK7</accession>
    <name>A0A401NNK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0011461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005220">
        <property type="protein sequence ID" value="GCB62417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNK7"/>
    <dbReference type="STRING" id="75743.A0A401NNK7"/>
    <dbReference type="OMA" id="AMNDFHE"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18505">
        <property type="entry name" value="BACK1_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18506">
        <property type="entry name" value="BACK2_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18308">
        <property type="entry name" value="BTB1_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18309">
        <property type="entry name" value="BTB2_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000054">
        <property type="entry name" value="Leucine-zipper-like transcription regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000065">
        <property type="entry name" value="Leucine-zipper-like transcription regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000024">
        <property type="entry name" value="Leucine-zipper-like transcriptional regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000049">
        <property type="entry name" value="leucine-zipper-like transcriptional regulator 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="339"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="563"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="736" mass="84256" checksum="047F73A54FDDFD89" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSX7</accession>
    <name>A0A401NSX7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005410">
        <property type="protein sequence ID" value="GCB63998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSX7"/>
    <dbReference type="STRING" id="75743.A0A401NSX7"/>
    <dbReference type="OrthoDB" id="8957176at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB63998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10625" checksum="F15177AAEAFD8A89" modified="2019-05-08" version="1">MLPCWDTQTRMRGDDPFAGMRDLKRFSDRAAAGDFLLLRAAGIRDPNDHILSQEDFDEITDFNDLPTSLFACNVHQSVFEDEQGRGTIGIPLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTA1</accession>
    <name>A0A401NTA1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005417">
        <property type="protein sequence ID" value="GCB64074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTA1"/>
    <dbReference type="STRING" id="75743.A0A401NTA1"/>
    <dbReference type="OMA" id="HREEEMF"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000735">
        <property type="entry name" value="Lactation elevated 1 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB64074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39178" checksum="9CFAF742AF813E70" modified="2019-05-08" version="1">MAASRTPLVSIGRLSSLLNAETRRLKHKLCPTNRGSFKGYILPASNSASPDTGEREKSSAIAPSVEGPLEHYEWLIKQGKLNDDVHQRRVTQSLQKLHEALKGYSPDQQNFFSKFFETSKPPKGLYVYGDVGTGKTMVMDLFYSHATVKRKSRVHFHGFMLDVHQRIHRLKQTLPKRKPGLMAKSYDPIAPIAAEISDESWLLCFDEFQVTDIADAMILKQLFENLFHNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKNYCEAIKLNSETDYRKRYLPGAGKLYYLCSGPGMVAHEIKAGGNEENGNAKEFAMGRKAKSMEFLYLLGGCRICVPWESVGNSDVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTB1</accession>
    <name>A0A401NTB1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0000235</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000042">
        <property type="protein sequence ID" value="GCB64089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTB1"/>
    <dbReference type="STRING" id="75743.A0A401NTB1"/>
    <dbReference type="OMA" id="RSRCIAM"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001588">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gs"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000523">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF203">
        <property type="entry name" value="OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01102">
        <property type="entry name" value="5HT6RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0085">Behavior</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019412644" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="13">
        <location>
            <begin position="18"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="43"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB64089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="360" mass="41324" checksum="07E62D55772028E2" modified="2019-05-08" version="1">MLLINLFALATLWDGNASRTQISHQEMLVGTILTTVDLVTLLGNVVVFICPALEKKLRTVTYMFILSLATADLLVACLVMPFSIIYEVTGVWMFGRMFCKVWISFDVMFCTASIVTLCFISLDRYCSVVTPYRYTKQMSRSRCIAMTITIWVYSFMISFLPVMQGWNEIPGMDFENNRECVFVTNRIFAIVASALAFYIPFLIMCTMYFFIYQASRLKAVRVMSQTLDLHYHPDSRRQDNLQLEHKATRTMGIIISAFVLCWLPYFVFNICIAVSGSQFNSATINHVFKVITWFGYCNSTINPLLYAFLNRDFQRALKKMLVCRRWRARVDIGDDMVSIVTFTKTVQGAECSVKSMDGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVF2</accession>
    <name>A0A401NVF2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2</fullName>
            <ecNumber evidence="3">2.7.1.105</ecNumber>
            <ecNumber evidence="4">3.1.3.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">6PF-2-K/Fru-2,6-P2ase heart-type isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0007591</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesis and degradation of fructose 2,6-bisphosphate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Forms a heterodimer with PFKFB3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.105" evidence="3"/>
    <dbReference type="EC" id="3.1.3.46" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01002790">
        <property type="protein sequence ID" value="GCB64832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVF2"/>
    <dbReference type="STRING" id="75743.A0A401NVF2"/>
    <dbReference type="OMA" id="RWIQERC"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF48">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="16">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="244"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB64832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="457" mass="53339" checksum="5D9A1CED71961AD8" modified="2019-05-08" version="1" fragment="single">KHRTLLKLRTQILTKRSWASHMTNSPTLIVMVGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGQYRREAVKSYKSYEFFRHDNEEAMKIRKECALAALKDVKTYLTDEKAQIAVFDATNTTRERRDLILDFARDSEFKVFFVESVCDDPDVIAANIKEVKVSSPDYAECEEDRIMDDFLKRIECYTVTYEPLDPDDYDKDLSFIKVINVGRRFLVNRVQDYIQSKIVYYLMNIHVYPRSIYLSRHGESEYNSIGKIGGDSELSAHGKQYAEILRQFVKEQKIPDLKVWTSQLRRTIQTAEALGIPYEQWKILNEIDAGVCEELTYSEIQDRYPDEFALRDQDKYHYRYPGGESYQDLVQRVEPVIMELERQGNVLVVAHQAVMRCLIAYFMDKGADELPYLKCPLHTVLKLTPVAYGCKMETFYLNVKAVNTHRDRPQNVSLNRTREEALSTVPHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVL6</accession>
    <name>A0A401NVL6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deubiquitinase DESI2</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Desumoylating isopeptidase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PPPDE peptidase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Palmitoyl protein thioesterase DESI2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein FAM152A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">S-depalmitoylase DESI2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0014831</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01008112">
        <property type="protein sequence ID" value="GCB64921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVL6"/>
    <dbReference type="STRING" id="75743.A0A401NVL6"/>
    <dbReference type="OMA" id="VYWTKPG"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1720.30:FF:000001">
        <property type="entry name" value="desumoylating isopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF6">
        <property type="entry name" value="DEUBIQUITINASE DESI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PPPDE" evidence="18">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB64921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="196" mass="21737" checksum="E3CA4D4EC39CF9FA" modified="2019-05-08" version="1">MANELVILNVYDMYWINEYTTSLGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGDSTELGDTFKFKEAIVMGSTDFTEDDVERIVEELGKEYKGNAYHLMHKNCNHFSSAISEILCGKEIPRWVNRLAHFSSCIPFLQSCLPKEWLTPAALQTSVSQELQDGLGEREDAAASTSASASNSRSTLPTSGHHTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWU4</accession>
    <name>A0A401NWU4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006870">
        <property type="protein sequence ID" value="GCB65349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWU4"/>
    <dbReference type="STRING" id="75743.A0A401NWU4"/>
    <dbReference type="OMA" id="HAQIPFI"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115491" checksum="0F407D93C9108E21" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXA0</accession>
    <name>A0A401NXA0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0007731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002853">
        <property type="protein sequence ID" value="GCB65502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXA0"/>
    <dbReference type="STRING" id="75743.A0A401NXA0"/>
    <dbReference type="OMA" id="RIPRNKA"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000006">
        <property type="entry name" value="Putative AP-3 complex subunit mu-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="151"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB65502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="393" mass="44237" checksum="D6EA31079C3E5AC7" modified="2019-05-08" version="1">MIHSLFLINHTGDIFLEKHWKSVVSRSVCDYFFEAQEKAGEADNVPPVIPTPHHYLVSTHRDRIFFDYFGECTEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNTITGSSNVGDQLPTGQLSNIPWRRAGVKYTNNEAYFDVTEEIDAIIDKSGSTVFAEIQGVIDACIKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERVLSFIPPDGNFRLMSYHVSSQNLVAIPVYIKHNISFRESGSTGRFDVTIGPKQTMGKTVESVLMIIHMPKGVLNMTLTAAQGTYTFDPVTKMLIWDIGKITLPKLPTLRGVISLQSTAPKPEENPTISVQFRIQQLAVSGLKVNRLDMYGERYKPFKGVKYVTKAGKFQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZP8</accession>
    <name>A0A401NZP8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001497">
        <property type="protein sequence ID" value="GCB66339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZP8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="112" mass="11926" checksum="38D419807C4E6820" modified="2019-05-08" version="1">MTLPRLRLRNAAPPGPLMARRRAGATSPPPPRARVAHARRAGFAAKEKAARSWSPSCAAVFLFAAGALCLIPEPIRGAKARDRIYSTKTGPSAQTGPCQPKSPPKPNRFCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZX9</accession>
    <name>A0A401NZX9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0000598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Identified in the spliceosome C complex. Interacts with SNW1/SKIP. Interacts with CDC40/PRP17; this interaction leads to CDC40 isomerization. Interacts with RBM22.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01000110">
        <property type="protein sequence ID" value="GCB66448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZX9"/>
    <dbReference type="STRING" id="75743.A0A401NZX9"/>
    <dbReference type="OMA" id="PYHKANF"/>
    <dbReference type="OrthoDB" id="5916692at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="18439" checksum="934BA63D366E8D01" modified="2019-05-08" version="1">MSGIPPDTWQPQSITLDTTMGTILLELYWKHAPKTCRNFAELTRRAYYNGTKFHRVISGFVVQGGDPTGTGRGGSSIYGKHFEDEIHKDLKFTGAGILAMANAGPDTNGSQFFITLGPTPLLDGKHTVFGRVCHGLSVVKRIELVETNRDDRPTDDVIILKAIVNVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0C9</accession>
    <name>A0A401P0C9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0015011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008303">
        <property type="protein sequence ID" value="GCB66557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0C9"/>
    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF10">
        <property type="entry name" value="DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12232" checksum="BE67B8AAB9A60759" modified="2019-05-08" version="1">MFFLIFTINVCNEFCYVQSNIKALAAESESCDTGTTPPERCIFGFMMSISGFLGVVTIYVRYKQVETLNQGDGHSINKLNRTSLVLGLISCLGLCIVANFQVMIHLHGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2H0</accession>
    <name>A0A401P2H0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005756">
        <property type="protein sequence ID" value="GCB67296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2H0"/>
    <dbReference type="STRING" id="75743.A0A401P2H0"/>
    <dbReference type="OMA" id="KPRAFTR"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd18650">
        <property type="entry name" value="CD_HP1beta_Cbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18654">
        <property type="entry name" value="CSD_HP1beta_Cbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000007">
        <property type="entry name" value="Chromobox protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000009">
        <property type="entry name" value="chromobox protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB67296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="196" mass="22862" checksum="10C144E1F0EC6D6C" modified="2019-05-08" version="1">MASASLLNLRLDPMGKKQNKKKVEEVLEEEEEEYVVEKVLDRRIVKGKVEYLLKWKGFSDDDNTWEPEENLDCPDLIAEFLQSQKIAHDGIDKTEGPKRKAESDTETEENKNKKRREEQEKPRGFARALEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEEEEKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2X1</accession>
    <name>A0A401P2X1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0005134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001571">
        <property type="protein sequence ID" value="GCB67453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2X1"/>
    <dbReference type="STRING" id="75743.A0A401P2X1"/>
    <dbReference type="OMA" id="IHVCAKN"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="122" mass="13352" checksum="057D274EBFAD48E5" modified="2019-05-08" version="1">MAAKSIIRSKQAAEAVDGTLTEVVCTVFNDYIFVVVTQYGKMGTLISVTPHSVGNEISKPTFSTKILMGKDEPLIHVYAKHLVTFVSEESGNKPVLLALALKEANVDSIKSIKQLIQSCRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2X7</accession>
    <name>A0A401P2X7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0013711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007117">
        <property type="protein sequence ID" value="GCB67505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2X7"/>
    <dbReference type="STRING" id="75743.A0A401P2X7"/>
    <dbReference type="OMA" id="MIPKDFF"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF35">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54664" checksum="27C9DC19979CDF86" modified="2019-05-08" version="1">MEEAAERPSPPGGMEEELASPAGRMEEEGQMVEEERASPAGRMEEEGQMEEEERASPAGRMEEEGQMEEEEQRPSPTGGEGDGAPVSTPSPPCEMVDLGGRRLESLPEHILHMPALQNLYLEGNAISGLSEDFFHQLPNLLWLDLRNNKLTMLPLSIGDHRCLKTLLLEGNPIRKLPVELGNLTSLKALNLRKCPIVFPPEAIMHQGLIAILAFLRMPILKAGHDTEMPSIEKLQLNVRTESSLSFSDEKERQRFKTLKQKLIQEEKKEEPSQSKKVWGAGFLSTISSIPREKTPNLNALFPELTAYDMTIQTKRKHELRLAALKEHKQKQAFIEQRMKDQKTLRDWRNQAKLMQEMKETERKQWSAKERNKELLVKNAPYATDPNYYHIVKNVDLKGPPICESRRSMNSGKEMEDKRAAKDKELQERIQKHIKLMRERRKRQKGNPQEELEAAKRDLEIAANLKSSLARRKIIDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P323</accession>
    <name>A0A401P323_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Interferon/interleukin receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004383">
        <property type="protein sequence ID" value="GCB67500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P323"/>
    <dbReference type="STRING" id="75743.A0A401P323"/>
    <dbReference type="OrthoDB" id="10007376at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF91">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon/interleukin receptor" evidence="2">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="220" mass="25085" checksum="718A7BCBFD538A35" modified="2019-05-08" version="1">MIPVAALEKLNPRSSILAFKENNWYYARVMAISKTANSTWSLSERFCPLDKTIIRAPNVQHTAGDRSISILINLPQVPLKEGVQRSIKDIFATIKYEVQLNQSPSNKTVFSALNESAYFKIESLEPNTNYCAKVQLSLRKEIFSKQSQPAHFCIQTLQERTLTIVLSMAFVFFGAIITGIFCCWAYSYIKHRRTLPQSLAKPFFQQGLMTYIYIRLTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3L2</accession>
    <name>A0A401P3L2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0010288</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004402">
        <property type="protein sequence ID" value="GCB67701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3L2"/>
    <dbReference type="STRING" id="75743.A0A401P3L2"/>
    <dbReference type="OMA" id="FWAPIVK"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB67701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="13950" checksum="CF21CD237A09E61F" modified="2019-05-08" version="1">MAVAGLRASYHRVLDKIGLMLPPKLRRIYDHPAGPRTVFFWSPIAKCGLVIAGLADLARPPNKLSVSQSGVLCATGLIWSRYSLVIIPKNWGLFAVNFFLGCAGLTQLIRIAKYRYDLKSEGEHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P550</accession>
    <name>A0A401P550_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003092">
        <property type="protein sequence ID" value="GCB68238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P550"/>
    <dbReference type="STRING" id="75743.A0A401P550"/>
    <dbReference type="OrthoDB" id="8196042at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="371" mass="39724" checksum="E5BCF34266F63236" modified="2019-05-08" version="1" fragment="single">YYYQRGILAKVEGQRLVYQFKEMPKNLVNIDDGDPSSSSVTQENPPNLAAYMLPAASAARSPATVPQSIVMSSIQTQQPRVISRLMPSVKKVSLQPTTVVSSLKATVGETVQRSVHLLPPEVMKGVQTAQTMQQTSVLRTVQLVQSAPPLHKEQKVITRNEPVSTPIPSVRTIKVSSQVPVVVSPGTQRVGTVTLQTVPLTTVITSTDLAMSSPKFVFQTIPSSHPVTVLKENVALHRSSLSTKIVTPTSFAVHGTSDQQVLPTSPKVLNNGTQATSSPAAVSAATPVVTFAATSQQVVSQPQGTVFASVIKAPETKQAVARQECREEAAGTSQQGEHRAQQSHVIVLTNAGMLPSHMVFRAGEHRVVDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P593</accession>
    <name>A0A401P593_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Islet cell autoantigen Ica1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004461">
        <property type="protein sequence ID" value="GCB68315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P593"/>
    <dbReference type="STRING" id="75743.A0A401P593"/>
    <dbReference type="OMA" id="YCTVTIV"/>
    <dbReference type="OrthoDB" id="2126778at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006723">
        <property type="entry name" value="Islet_autoAg_Ica1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF3">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04629">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01237">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Islet cell autoantigen Ica1 C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="16230" checksum="490AAE82ABF24903" modified="2019-05-08" version="1">MDSQTNEKDEMALLNEILNGTSLEEGDFSKEWQAAFGEDLSFPNSPAAGESDQSPSPSGFLPSQLFDKSLGDASFSVASWAADGVSLQTTSQSKEQLNGLIENISKNPFKASQKNPTDLSTWFNLFADLDPLSNPDAIGRTDKQHELLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5Q6</accession>
    <name>A0A401P5Q6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008529">
        <property type="protein sequence ID" value="GCB68469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5Q6"/>
    <dbReference type="OMA" id="NRTEEYH"/>
    <dbReference type="OrthoDB" id="10010556at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038826">
        <property type="entry name" value="CCDC178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35088">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35088:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="11730" checksum="C9E3079ED42CEEF6" modified="2019-05-08" version="1">MVKLALAFMENTNRTEEYHQLQQTYKTAKLKLADTYNCRQKTEVCIKDYLQLSALHTKMHKALVDYYKQQGLYSQASIARSQALSHENAQEIIAVQVCCKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6T3</accession>
    <name>A0A401P6T3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-glucose:glycoprotein glucosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007268">
        <property type="protein sequence ID" value="GCB68837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6T3"/>
    <dbReference type="STRING" id="75743.A0A401P6T3"/>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF3">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="2">
        <location>
            <begin position="295"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="3">
        <location>
            <begin position="434"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="4">
        <location>
            <begin position="710"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB68837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128799" checksum="8313D0D7E47A574F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P712</accession>
    <name>A0A401P712_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0005383</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Golgi apparatus</location>
            <location evidence="15">Golgi stack membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01001667">
        <property type="protein sequence ID" value="GCB68906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P712"/>
    <dbReference type="STRING" id="75743.A0A401P712"/>
    <dbReference type="OMA" id="DWLYNGF"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
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        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="199"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB68906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="216" mass="24093" checksum="30B0587D482AD3CA" modified="2019-05-08" version="1">MGGVIRKLNVILKCPDSAMSGLLDWLYNGFTNMLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDNRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHAQARRVWKNYLPAINGIVFLVDCADHSRLAESKVELDALMTDETISNVPVLILGNKIDRSEAISEEKLREIFGLYGQTTGKGTVPLKELNTRPLEVFMCSVLKRQGYGEGFRWLSQYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7G6</accession>
    <name>A0A401P7G6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005944">
        <property type="protein sequence ID" value="GCB69010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P7G6"/>
    <dbReference type="OMA" id="XPPHAGK"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000010">
        <property type="entry name" value="neurobeachin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF64">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF4704" evidence="3">
        <location>
            <begin position="230"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="888"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="936"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1551"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1436"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1456"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1571" mass="174219" checksum="A866DA5B976FC57A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7K5</accession>
    <name>A0A401P7K5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-14</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">scyTo_0005419</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Early endosome membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01001680">
        <property type="protein sequence ID" value="GCB69102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7K5"/>
    <dbReference type="STRING" id="75743.A0A401P7K5"/>
    <dbReference type="OMA" id="TAGQESW"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04122">
        <property type="entry name" value="Rab14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000344">
        <property type="entry name" value="Ras-related protein Rab-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030702">
        <property type="entry name" value="Rab14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GCB69102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="261" mass="29264" checksum="192F91C8A153C48A" modified="2019-05-08" version="1">MAGGGGTVGRRRGIKKNNTQKPREKIRSKNCWWRLCVVLFCRRRAKMATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLISEPQPQREGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8B5</accession>
    <name>A0A401P8B5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial thiamine pyrophosphate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0008368</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>thiamine phosphate(out) + thiamine diphosphate(in) = thiamine phosphate(in) + thiamine diphosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:73383"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003189">
        <property type="protein sequence ID" value="GCB69358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8B5"/>
    <dbReference type="STRING" id="75743.A0A401P8B5"/>
    <dbReference type="OMA" id="LMKCGAG"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042723">
        <property type="term" value="P:thiamine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="118"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="223"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB69358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="343" mass="38285" checksum="99D1A4EA967C3226" modified="2019-05-08" version="1">MVGYDPGTQEGGRGLSSSEVAAAGSMSGLLTRVLINPLDVIKIRFQLQIERLSLFEPAAKYHGVLQATNTIFQEEGLQAFWKGHIPAQLLSISYGAVQFVSFEFLTKFVHNTVRYDSRNPTMHFVCGGLAACSATVTVQPLDTLRTRFVAQGEPKVRKWGFAFYKSLWHAVVTMYRKEGPLSFYRGLTPTVLAVFPYAGFQFAFYNIFQSISKWAVTPRQTRMGNIENLLCGSCAGVISKTLTYPFDLLKKRLQVEGFGQARAAFGPVQSYSGFLDCACQVAQREGLKGFFKGLSPSMLKAAISTGFSFFWYELFCDILDNRKESTGYQQHLNTDVRHKTPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8E0</accession>
    <name>A0A401P8E0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0013957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007332">
        <property type="protein sequence ID" value="GCB69340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8E0"/>
    <dbReference type="STRING" id="75743.A0A401P8E0"/>
    <dbReference type="OMA" id="VGRQRYT"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051223">
        <property type="term" value="P:regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000002">
        <property type="entry name" value="Sorting nexin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF1">
        <property type="entry name" value="SORTING NEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB69340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="165" mass="19174" checksum="AC0D4FB0B94A7212" modified="2019-05-08" version="1">MAEALPDTRRLLTKPQNLNDAYGPPSNFLEIDVGTPQTMGVGRQRYTTYEVRIKTNLPIFKLKESSVRRRYSDFEWLRNELERESKVVVPPLPGKALFRQLPFRGDDGIFDDSFIEERRQGLEQFINKVAGHPLAQNERCLHMFLQEEIIDKNYTPAKVKHAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8N8</accession>
    <name>A0A401P8N8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ephrin RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0001057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000223">
        <property type="protein sequence ID" value="GCB69453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8N8"/>
    <dbReference type="STRING" id="75743.A0A401P8N8"/>
    <dbReference type="OMA" id="RISWFIV"/>
    <dbReference type="OrthoDB" id="6250301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10425">
        <property type="entry name" value="Ephrin-A_Ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000005">
        <property type="entry name" value="Ephrin A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034252">
        <property type="entry name" value="Ephrin-A_Ecto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019765">
        <property type="entry name" value="Ephrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF4">
        <property type="entry name" value="EPHRIN-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01299">
        <property type="entry name" value="EPHRIN_RBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019364806" description="Ephrin RBD domain-containing protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="13">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB69453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="222" mass="25695" checksum="55E7A17726E0173A" modified="2019-05-08" version="1">MMNVELAVLLFLALWVCVWTEDSGKVVADRYAVYWNSTNPRFHRGDYTVDVCINDYLDIYCPHYDDSVPEEKTESYILYMVNFDGYRSCDHKDNGFKRWECNRPRTPNGPLKFSEKFQLFTPFSLGFEFRPGNEYYYISSPHPNIVGKPCLKLKVYVRPTNSCMEAIGVNEGDFDVNNSSVEASDDSIYESPEPYHNNNGITTFRISWFIVATALLLLFLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P936</accession>
    <name>A0A401P936_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0005506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001722">
        <property type="protein sequence ID" value="GCB69593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P936"/>
    <dbReference type="STRING" id="75743.A0A401P936"/>
    <dbReference type="OMA" id="NEDCTFK"/>
    <dbReference type="OrthoDB" id="8909943at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018814639" description="Fibroblast growth factor" evidence="2">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="207" mass="23335" checksum="65BDEFE8CFBACAFD" modified="2019-05-08" version="1">MGFSLADWISLQLAVLLAASLVRATPLGRTDSGAQLERGWARQIRLMHLYMEGNSKHLQMNPDGHIDSSNSQNYYTLLEIKAVEPGHVVIKGVRTGRYLCMDTEGSIFGSMTYCADDCNFKEEQLPTFYNVYHSPRHKKVLSLSLEKRPFIPNRELPPLSTFLPLEDQLPTTTHSRRNPEREANDTDPFGMRSGQQASPKLSRTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9V6</accession>
    <name>A0A401P9V6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0001144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the connexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000243">
        <property type="protein sequence ID" value="GCB69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9V6"/>
    <dbReference type="STRING" id="75743.A0A401P9V6"/>
    <dbReference type="OMA" id="CDSFPCP"/>
    <dbReference type="OrthoDB" id="8934037at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000001">
        <property type="entry name" value="Gap junction alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF20">
        <property type="entry name" value="GAP JUNCTION BETA-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0303">Gap junction</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="12">
        <location>
            <begin position="148"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="282" mass="32294" checksum="9877E59202C6EF3E" modified="2019-05-08" version="1">MNWPVFYTVLIGVNKHSTGIGRIWLSVLFIFRIMVLVVAAESVWGDEKTGFTCNTQQPGCNSVCYDQFFPISHIRLWALQLILVATPALLVAMHVAHKHHVEKKILRIKQLTGEAGEMDIEKVTKRKMHIIGSLWWTYVVSIIFRVIFEVAFLYIFYLIYPGFRMIRLVKCDAFPCPNTVDCFVSRPTEKTIFTIFMLVVSGVCVLLNIAEVGYLIIKACVRQCQKREPRSSKGAFYGRKFPQFRPNEINELLSNQESAFLKNSKMNAVRKSASNKDVCRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAH5</accession>
    <name>A0A401PAH5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0008504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003274">
        <property type="protein sequence ID" value="GCB70118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAH5"/>
    <dbReference type="STRING" id="75743.A0A401PAH5"/>
    <dbReference type="OMA" id="HRVEDKN"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB70118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30578" checksum="C53CA28C04E830C1" modified="2019-05-08" version="1">MRQARTSGTSTDSDQNQATGQNLSTDRKITISNHGGFKEKLAKMESTLNQANSSTSSTTIDWLVPHPFVCEKQFEFCGHPLNIARYFGGNLGFSASIWESALVLCQYFEQEKISFSGRKVIELGSGTGIVGILAVLLGGDVTMTDKENVLSQIEHNVSTNIPSTFRHRSKVCALSWGKDHIKFPADYDFILGSDIVYTSLTYPLLLETLLHLSNEPTIIYLASKLRTGNQSTTFHETLLPQHFNCQLVHRVEDKNINVYKVSKLGSKRRDDLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBX8</accession>
    <name>A0A401PBX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0001328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000294">
        <property type="protein sequence ID" value="GCB70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBX8"/>
    <dbReference type="STRING" id="75743.A0A401PBX8"/>
    <dbReference type="OMA" id="NFEWSGC"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19336">
        <property type="entry name" value="Wnt_Wnt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009142">
        <property type="entry name" value="Wnt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF101">
        <property type="entry name" value="PROTEIN WNT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01844">
        <property type="entry name" value="WNT4PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="438" mass="49412" checksum="2FB93A4C7DF1FF00" modified="2019-05-08" version="1">MSSRHKDRERNLRNKTQQAILMQHSTADIGATCDEVWEKEEELVEIEWIFLWAKIFFPKPVTNNLENYKRLVALYAIFFNEGFLNFAMTPVSVLRSLLVLVLALFATNASNWLYLAKLSSIASIQDEETCERLKGLINRQIQICKRNVEVMDSVRRGAELAIEECQHQFRNRRWNCSTVDTLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPDGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRPLMNLHNNEAGRKAILNNMRVECKCHGVSGSCEVKTCWKAMPPFRKVGNVLKEKFDGATEVEQRKVGSTKVLVPKNSQFKPHTDEDLVYLDSSPDFCDHDIRNGVLGTSGRQCNKTSKAIDGCELMCCGRSFNTEEVEIVERCSCKFHWCCFVKCKQCHKVVEMHTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCS3</accession>
    <name>A0A401PCS3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0008720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003386">
        <property type="protein sequence ID" value="GCB70922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCS3"/>
    <dbReference type="STRING" id="75743.A0A401PCS3"/>
    <dbReference type="OMA" id="FCMISSF"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF120">
        <property type="entry name" value="ZINC TRANSPORTER ZIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB70922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31488" checksum="5CEC60E13A286CE9" modified="2019-05-08" version="1">MNGTAVLAHMASNPVLTCHRLFLSLCSCFAGGVFLAACLLDVLPDYLSHINEELDKLQVNTIFPLPEFVMAVGFFLVLTLERIVLECHSSSLSASTPLIVHRARAATHCSDDHVNQCVRINCNSVETTDDHVHIDVNAHSAFRSFILFLSLSLHSLFEGLPIGLQQTESKVLQIFAAILIHKSIIVFSLALKLVQSNVPRGRVMLYIIIFAIMSPLGIVIGIIITQVKSASNALAQSILEGITAGTFIYITFLEILPHELNSTDERLLKLLGIIFGFSIMTMLSFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEF1</accession>
    <name>A0A401PEF1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0008846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="EMBL" id="BFAA01003475">
        <property type="protein sequence ID" value="GCB71475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEF1"/>
    <dbReference type="STRING" id="75743.A0A401PEF1"/>
    <dbReference type="OMA" id="QIGDQKR"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF15">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="242"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB71475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="409" mass="46370" checksum="71A54BF14305D924" modified="2019-05-08" version="1">MKFVRFLMKNTALANVPKHIDHFSKFSPSPLSIKQFLDFGSTNACEKTSFMFLRQELPVRLSNIMKEINLLPDRLLGTPSVQLVQSWYIQSLLDILEFYHRNPDDHSVLSGFTDALITIRNRHNDVVPTMAQGVIEYRESFLEDSITSQNVQYFLDRFYMSRISIRMLINQHTLIFGGTTNPAHPKHIGSIDPDCEVVDVIRDAYETAKLLCDQYYMDSPALEVDQYNAVNGSGPVHIVYVPSHLYHMLFELFKNAMRATVESHESSPRLPSIKVKVALGGEDVTIKMSDKGGGVPLSKIDRLFSYMYSTAPTPHLGSSRGTPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTDAVIYLKALSKDSVERLPVYNKSAWRHYQHSHEADDWCVPSSDPKNLAVHTIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEU0</accession>
    <name>A0A401PEU0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0001637</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000378">
        <property type="protein sequence ID" value="GCB71631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEU0"/>
    <dbReference type="STRING" id="75743.A0A401PEU0"/>
    <dbReference type="OMA" id="TAYDKNY"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000062">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000002">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01107">
        <property type="entry name" value="Na_K_ATPase_bet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF10">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00390">
        <property type="entry name" value="ATPASE_NA_K_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00391">
        <property type="entry name" value="ATPASE_NA_K_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB71631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="305" mass="35109" checksum="2374B5CE305459EC" modified="2019-05-08" version="1">MARAKGKEGDGGWRKFLWDSEKKQFLGRTGSSWFKIFLFYLIFYGCLAGIFVGTIQVLLLTISEFEPKYQDRVAPPGLSHTPYSFKTEISFSMSDPKSYESYVTSLNKFLDHYNDSSQGGNSPFEDCETVPTGYISRGPLDKSEGQKRACRFYRTWLLNCSGIQDPNYGYADGSPCIVTKLNRILNFYPKPPQNSSELPEKLRTNYNEFIIPIHCAAKKEEDRDNIGPVNYYGMGGYSGFPLQYYPYYGKRLQEKYLQPLVAIQFMNVTQNTEVRIECKVYGDNINYSDKDRFLGRFEIKFAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG84</accession>
    <name>A0A401PG84_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0006188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002042">
        <property type="protein sequence ID" value="GCB72160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG84"/>
    <dbReference type="STRING" id="75743.A0A401PG84"/>
    <dbReference type="OMA" id="SENECSY"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000003">
        <property type="entry name" value="kalirin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="27"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB72160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="323" mass="37025" checksum="2BC71C902AAF89D1" modified="2019-05-08" version="1">MAPMLPWLSTQCKDIAGPFRNDGLKVSDVMPIMKEKVAFVSGGRDKRGGPILTFPARSNHDRIKQDDLRQLVTYLASVPSEDVSKRGFTVIIDMRGSKWDLIKPLLKTLQESFPADIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLSKLVDPSQLTEEFDGTLEYNHDEWIELRLALEEFISSAVHLLSRLEDLQEMLARKEFPLDVEGSRKLIDEHTQLKKKVIKAPVEELDHEGQRLLQCIRCSDGFSGKNCISGSADFQSVVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKVRLHLYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGN9</accession>
    <name>A0A401PGN9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000449">
        <property type="protein sequence ID" value="GCB72297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGN9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8241" checksum="267721797152082B" modified="2019-05-08" version="1">MSCNGSHTKKLFNLLGWITIGTLTGHNRQGLQPRTSDQKGPQRRIRCSLLCVTNGDDDNETFQLYVAECLEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGT4</accession>
    <name>A0A401PGT4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000448">
        <property type="protein sequence ID" value="GCB72294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGT4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="11692" checksum="C5B9491022FD2620" modified="2019-05-08" version="1">MKATLKTVPNILESDLRSVKKTDALLIPLLMAARCELDKAVLLQHNLEKQNFTKQLLSDNLSSREMDVETKIIMQCVWRMGCFWVDYRHAVIVLFTIALKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGT5</accession>
    <name>A0A401PGT5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial phospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphatidylcholine-hydrolyzing phospholipase D6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phospholipase D6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0001943</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cardiolipin + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:44885"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000455">
        <property type="protein sequence ID" value="GCB72342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGT5"/>
    <dbReference type="STRING" id="75743.A0A401PGT5"/>
    <dbReference type="OMA" id="RIWEEFD"/>
    <dbReference type="OrthoDB" id="5205528at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09171">
        <property type="entry name" value="PLDc_vPLD6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB72342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="215" mass="23875" checksum="001905781E4466D7" modified="2019-05-08" version="1">MLLTAVSAWRGLVVVVGLSLAAEGLYYVISHLKRLRERRPAQVLFFPAPVTCVRPLLLSSPGHCRCGLSHRESALSCLTRLLISARRSLDVCVFTISSLELSSTVLAVHGRGVRVRVITDSDYMALAGSQVGTFRRAGIEVRHDQDTNYMHHKFALIDGLTLVTGSLNWSAQGIFGNKENVIIIENTDIVKAFVEEFGQLWNEYDPAKYSFSPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGU1</accession>
    <name>A0A401PGU1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Growth hormone-regulated TBC protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0006262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002080">
        <property type="protein sequence ID" value="GCB72345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGU1"/>
    <dbReference type="STRING" id="75743.A0A401PGU1"/>
    <dbReference type="OMA" id="RICHQAR"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000029">
        <property type="entry name" value="Growth hormone-regulated TBC protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF10">
        <property type="entry name" value="GROWTH HORMONE-REGULATED TBC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB72345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="222" mass="25468" checksum="D5042B51DB927715" modified="2019-05-08" version="1" fragment="single">INRTFPDNVHFRRTANPSLQDALFNILVAYGNHNKIIGYCQGMNFIAGYLLIVTKDEEKSFWLLDALIAKIVPDFYCPTMIGLKTDQEVLSQLVRMKVPAVAALMEKHNVMWTLVVGRWFICLFIDILPVETVLRIWDCLFYEGSKVTFRVALTLIKYHQASILEANNFLAVCEKFKEITHGALVKDCHVFMQKIFSEPGRLPLATITKLREWSRATIDGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHM1</accession>
    <name>A0A401PHM1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0006381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002138">
        <property type="protein sequence ID" value="GCB72589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHM1"/>
    <dbReference type="STRING" id="75743.A0A401PHM1"/>
    <dbReference type="OMA" id="GYTEEWL"/>
    <dbReference type="OrthoDB" id="260824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21150">
        <property type="entry name" value="PUA_NSun6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF34">
        <property type="entry name" value="TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="183"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="284"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB72589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="513" mass="55799" checksum="B600D298D4885253" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI83</accession>
    <name>A0A401PI83_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000538">
        <property type="protein sequence ID" value="GCB72837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI83"/>
    <dbReference type="STRING" id="75743.A0A401PI83"/>
    <dbReference type="OMA" id="HQEEMPQ"/>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF21">
        <property type="entry name" value="CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019532932" evidence="2">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB72837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="375" mass="42096" checksum="82EB659C050D0C40" modified="2019-05-08" version="1">MQLAFLIINRWLSRLGLATVGYAEKEQRLRHDQDYWSESEQEDADTPSTPKQESPPPPYDTYPRAPSVNCASPYLEPKHNRLSSTETSHSHSSHEEFRPEQVGGTESPVRKPGAWERRSWQDLIETPLTSSGLHYLQTLPLEDSVFCEAGLPTPEHRRQSTLPAQRCQIQDHYGPFPLAEGERWPGRSGGGGKPRSFTLPRDGGFSHSCQSSSIGVPGAQAELIQKQDIKEEKQEENEPTPEKIGDSLQDLYKALENASVSPLGEHRLSTKQEFKKSFVKRCDNPVINEKLHKLRILKSTIKAKEGEVAIIDKILDNPSLTSKEFQGWKQTYVELFMDICQNNAATESINGATEQAAPTPTPPLVHTHSYIETHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI99</accession>
    <name>A0A401PI99_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000535">
        <property type="protein sequence ID" value="GCB72818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI99"/>
    <dbReference type="OMA" id="TMSKQDT"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="115" mass="12828" checksum="BF9CE80CA1C3EE48" modified="2019-05-08" version="1" fragment="single">MTQDTTIQDTTTQDTTTQDTMTQDTTARDTMTQNTTTQDIMTQDTTTQDTTAQNTTAQDTTIQDTKTQDTTARDTTTQDTTARDTKTKDNMIEDTMTQDTTTLDSTARDTMIQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJG6</accession>
    <name>A0A401PJG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000614">
        <property type="protein sequence ID" value="GCB73274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJG6"/>
    <dbReference type="STRING" id="75743.A0A401PJG6"/>
    <dbReference type="OMA" id="CVIAFID"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000141">
        <property type="entry name" value="Thioredoxin domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="77"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB73274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="225" mass="26040" checksum="B536DEEBE9A1BFBE" modified="2019-05-08" version="1">MASNPSLAMLSKVLEQQMLQTTEIVEQHLDTEIEKFEKLDADELEKLREKRLESMKKAQHQKQEWLSKGHGEYKEIASEKDFFQEVKESKNVVCHFYRDTTFRCQIVDKHLAILAKKHFETKFIKLNAEKAPFLSERLRIKVIPTMVLVKDGKAKDYIVGFDDLGCTDNFTTETLEWRLGCAAIINYSGNLMEPPFQLQRKSGCITKMEKKAIRGKSNDSDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJX8</accession>
    <name>A0A401PJX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0002546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000644">
        <property type="protein sequence ID" value="GCB73444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJX8"/>
    <dbReference type="STRING" id="75743.A0A401PJX8"/>
    <dbReference type="OMA" id="CESHIMN"/>
    <dbReference type="OrthoDB" id="257992at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005228">
        <property type="term" value="F:intracellular sodium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000011">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000168">
        <property type="entry name" value="Potassium sodium-activated channel subfamily T member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF14">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY T MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="13">
        <location>
            <begin position="315"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB73444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="413" mass="47376" checksum="DCB9F0563717B1E7" modified="2019-05-08" version="1">MAGTKLKPSSSEPEAVMKAITQNAKDANVNSSPKAARRMGSFGSDYGPRVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKVLTCVLYIIRVLLDDPTQGIECSGCQNKNYSNSSSSDKIDWGSIFWVNRPLPLWGIQGNIWEQIFRVSFILEMINTVPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDLHRAIQRTQSAMSNQVSILICTLVCLVFTGTCGIQHLERAGDKLTLFKSLYFCIVTFSTVGFGDVTPQIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDLQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDDAEACFILSSRNEVDRTAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKG7</accession>
    <name>A0A401PKG7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000694">
        <property type="protein sequence ID" value="GCB73627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKG7"/>
    <dbReference type="STRING" id="75743.A0A401PKG7"/>
    <dbReference type="OMA" id="PPVQGKY"/>
    <dbReference type="OrthoDB" id="8958271at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8393" checksum="F3990CD51B34AD25" modified="2019-05-08" version="1">MSRTPSTSHEIQMDVFDNPPVQGKYAKRKSRFKRSDGSTSSDTTSNSFVRQDTTVVKKNIFQATQFLAPHGKANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKW6</accession>
    <name>A0A401PKW6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0002851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR0 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000734">
        <property type="protein sequence ID" value="GCB73769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKW6"/>
    <dbReference type="STRING" id="75743.A0A401PKW6"/>
    <dbReference type="OMA" id="LIQQNWA"/>
    <dbReference type="OrthoDB" id="9926883at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000031">
        <property type="entry name" value="Nuclear receptor subfamily 0 group B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033544">
        <property type="entry name" value="NR0B1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24081:SF8">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24081">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="10">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB73769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="271" mass="30625" checksum="9DD232CDDB9380AE" modified="2019-05-08" version="1">MACVSQSVSFDKCHCGQGSHSSILYSILNKDHPSESSCCHYRHHHHPSALGCSCEFRRRVVLKTPEHTCRLALEVLLKTLNFIKNLPSFCQLAEGDQVLLLQNCWTPLFVLGLAQERVDFEVAEAVAPSLLRKILLNQKVMDGQNQEAALNVPTLAEVQRVKIFLMKLWSMDVSTKEYAYLKGITLFNPDVPSLRMPQYILALQQEAQHTLNEFVSMVNNGDQARFARILLILSTLRMVSATSVAELFFRPVLGKVNMNDLLLEMLCTKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PL95</accession>
    <name>A0A401PL95_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0002972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000775">
        <property type="protein sequence ID" value="GCB73890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PL95"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB73890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7481" checksum="1A031C91D6AE0800" modified="2019-05-08" version="1">MHSEVEKFSSNSTWSQIQNLVEMRHLVEMHPLNNVQLFVAFVLCSGTMGESCVADGNSRVDLLKLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PME3</accession>
    <name>A0A401PME3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0003401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000917">
        <property type="protein sequence ID" value="GCB74312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PME3"/>
    <dbReference type="STRING" id="75743.A0A401PME3"/>
    <dbReference type="OMA" id="CGDPVHT"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06554">
        <property type="entry name" value="ASCH_ASC-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056994">
        <property type="entry name" value="TRI4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056993">
        <property type="entry name" value="TRIP4_3rd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23135">
        <property type="entry name" value="TRI4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23134">
        <property type="entry name" value="TRIP4_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating signal cointegrator 1 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Activating signal cointegrator 1 third" evidence="3">
        <location>
            <begin position="280"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB74312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="57239" checksum="06907877E02940E7" modified="2019-05-08" version="1">METLLRWCQEELVRKFSLEVNEELIQYILSIESAEEIEEYVIDLIQGTDGKKRTFIDELLKRWKRSQESLTPGQVQSYRKKDEVPDSSKAGDQLKKSKRKGRNKQEPLLASESQQPAEEVKTPMDLVKVQEANSASKKKTKYLSLYTKEGEDRLAVILPGRHPCECLGQMHKLINNCLSCGRIVCMQEGSGPCLFCGSLVCSKEEQEILVRDSNKSQRLRKKLMATTGAERAGNPDVLERELLPHQEMVLKAGLEKAVLHKDKLLEYDKTSARRTQVIDDESDYFAADSNQWLSKQEREALRKKEEELRELRHASRRTQPITIDFAGRRVLEDQGSLDQYYSRLDDLVEETKAGSQNNTSSKQVEWNKQQEQAEGRTWYTSHRGRLWIAATAKSPSTQEITAIEGTYRAMHARDIEFPKDYPTGCLLGCVDVTDCVSQEQYREQFTDQECGSPFVFVCTNPQELLVKFPIKGQHKIWKLDSRIHQGMKKALMRQKQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN39</accession>
    <name>A0A401PN39_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0003581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000989">
        <property type="protein sequence ID" value="GCB74491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN39"/>
    <dbReference type="STRING" id="75743.A0A401PN39"/>
    <dbReference type="OMA" id="HQQKAMN"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17004">
        <property type="entry name" value="CID_SCAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12462">
        <property type="entry name" value="RRM_SCAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000004">
        <property type="entry name" value="splicing factor, arginine/serine-rich 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000094">
        <property type="entry name" value="SR-related CTD associated factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034370">
        <property type="entry name" value="SCAF8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF1">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CID" evidence="10">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="497"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="875"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="795"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB74491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1153" mass="128695" checksum="59A4CCD03271BE33" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN64</accession>
    <name>A0A401PN64_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0003681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001028">
        <property type="protein sequence ID" value="GCB74590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN64"/>
    <dbReference type="STRING" id="75743.A0A401PN64"/>
    <dbReference type="OMA" id="RWLKGWE"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="401"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB74590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="933" mass="106118" checksum="672DD3244D787C61" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNF7</accession>
    <name>A0A401PNF7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0003729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the distal-less homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001048">
        <property type="protein sequence ID" value="GCB74638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNF7"/>
    <dbReference type="STRING" id="75743.A0A401PNF7"/>
    <dbReference type="OMA" id="HEYYPSQ"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000048">
        <property type="entry name" value="Distal-less homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022135">
        <property type="entry name" value="Distal-less_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF28">
        <property type="entry name" value="HOMEOBOX PROTEIN DLX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12413">
        <property type="entry name" value="DLL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="156"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB74638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="299" mass="34094" checksum="A49BC1EB2FE9AB14" modified="2019-05-08" version="1">MNLCFRKIDKRRLRCWRKSILSGTMSGTYEKKLPALLTDIQGSMGCHAAKDSPTLPESTATDIGYYNPQSCHPQHDYYPASAYSQPVNHYPYHQFNLNNIPGPASYSQKADYAYSNSYRQYGHFNRDPQMSAIERVSVKEEPEPEVRIVNGKPKKIRKPRTIYSSFQLAALQKRFQKAQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKLYKNGELTMEHSPNNSDSMACNSPPSPAVWESHSSTRNPLQHQTQQNSQSYLDDFNHWYPPHPSGSHLAATNSLHQPPPQSTGAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPP6</accession>
    <name>A0A401PPP6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012396">
        <property type="protein sequence ID" value="GCB75104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPP6"/>
    <dbReference type="STRING" id="75743.A0A401PPP6"/>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10469" checksum="51A9617598FC82E8" modified="2019-05-08" version="1">MSLVLHLKKISNLSGKYDRQIRITFRGYTHVTKKVKCELEAVFNEILVDLEVRYQPVEGAVGLWSEHDFVVDISDRNALIIENEGYQPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRY6</accession>
    <name>A0A401PRY6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0020958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BFAA01017741">
        <property type="protein sequence ID" value="GCB75899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRY6"/>
    <dbReference type="STRING" id="75743.A0A401PRY6"/>
    <dbReference type="OrthoDB" id="8878430at2759"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB75899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13701" checksum="AD6D112ADFB5E736" modified="2019-05-08" version="1" fragment="single">NGDFVALDLGGTNFRVLLVKIRSGKRRTVEMHNKIYAIPLEIMQGTGEELFDHIVHCISDFLDYMGMKGARLPLGFTFSFPCEQKSLDEGILLTWTKGFKATDCEGEDVVTMLRDAIKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS87</accession>
    <name>A0A401PS87_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012587">
        <property type="protein sequence ID" value="GCB76006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS87"/>
    <dbReference type="STRING" id="75743.A0A401PS87"/>
    <dbReference type="OrthoDB" id="9644022at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053282">
        <property type="entry name" value="RGS_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47079">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47079:SF1">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="119" mass="13763" checksum="36065F7A7A71FBB2" modified="2019-05-08" version="1">MIPIYIFKDSQWELQPELPSELRSNVTGFIKWLEEYRLPHFLQTDLYLHFVLCELLLDAEIPEIPESHINAVESTGSVSILQFSEDSESSESRSSKRDVNETEVNEQGSPMGEYQRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUM6</accession>
    <name>A0A401PUM6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012750">
        <property type="protein sequence ID" value="GCB76773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUM6"/>
    <dbReference type="STRING" id="75743.A0A401PUM6"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051766">
        <property type="entry name" value="TXND_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46135:SF4">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46135">
        <property type="entry name" value="NME/NM23 FAMILY MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="2">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="2">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="257" mass="30203" checksum="88E82BDB4A27F6F2" modified="2019-05-08" version="1" fragment="single">AGKIADYVKGVNAPVINKKIVAFLENEIEFYEKGVERQEVETIQLYDVEDEMEDFMQAAISKQVDKLFRVLVIKPNTLITGNDNVIKEQISEAGFQIMAEEMVHLTEEEAKELYEHKKHQRNFEEIVQTMSSGVCDILLLSEEGEMKDFEHEFDVQEAEMVKTNDEDSDIRELAYRLFSFFFPTVYEKFKKTEKTLAIIRPQLLQQQKGEILEEITNARFTIGRQKEIKLTEQQMTKFYSLNEEISLPREFVEYMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUX1</accession>
    <name>A0A401PUX1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010166">
        <property type="protein sequence ID" value="GCB76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUX1"/>
    <dbReference type="STRING" id="75743.A0A401PUX1"/>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17410" checksum="85CDADB994EBBEDF" modified="2019-05-08" version="1">MYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETDQGYKGLSIRSVCWKADRILAGTQDSEIFEVMVRERDKPLLIMQGHCEGELWGLAAHPKKPLVVTGSDDRSVRVCGSEKQQGNAEEAVERENSAWEEKEQEEKEAGTKASTMPSLQMGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVP0</accession>
    <name>A0A401PVP0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012825">
        <property type="protein sequence ID" value="GCB77133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVP0"/>
    <dbReference type="STRING" id="75743.A0A401PVP0"/>
    <dbReference type="OMA" id="MLAYVHY"/>
    <dbReference type="OrthoDB" id="8772552at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8185" checksum="3071C5634BE5677F" modified="2019-05-08" version="1">MGSSCGSDLLLPLSERLRLPIEQVNFAMCQLFGLFAAFLFRNYLHPSKTNHAIRHVIVTLLGLHFAFFCFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWY3</accession>
    <name>A0A401PWY3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015555">
        <property type="protein sequence ID" value="GCB77630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWY3"/>
    <dbReference type="STRING" id="75743.A0A401PWY3"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="590" mass="65270" checksum="15A7E491E6576311" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX47</accession>
    <name>A0A401PX47_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014250">
        <property type="protein sequence ID" value="GCB77724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX47"/>
    <dbReference type="STRING" id="75743.A0A401PX47"/>
    <dbReference type="OMA" id="WESHEQA"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="166" mass="19504" checksum="727BD154A3B8E1DC" modified="2019-05-08" version="1">MQEAQTKTIGKKAVENLHNQNEAKIHQKYEETEQVHAILHNKIQLLQEEARLAKNEVEKMNAIAEAEKLRSLELENKLHDNTWENHEKLRLWETNEFVLTEKNRIIDQLTQALRTKDLQIGQLNKENQNVVDNHVGDLEYRVEELTGTLRQKENEVEVSACFKLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY75</accession>
    <name>A0A401PY75_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-3-phosphate phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.21</ecNumber>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspartate-based ubiquitous Mg(2+)-dependent phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phosphoglycolate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0018558</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>sn-glycerol 1-phosphate + H2O = glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:46084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="EC" id="3.1.3.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>sn-glycerol 3-phosphate + H2O = glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:66372"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="EC" id="3.1.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.21" evidence="10"/>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01013043">
        <property type="protein sequence ID" value="GCB78099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY75"/>
    <dbReference type="STRING" id="75743.A0A401PY75"/>
    <dbReference type="OMA" id="DQENIHT"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043136">
        <property type="term" value="F:sn-glycerol 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF92">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="19">
        <location>
            <begin position="342"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB78099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="474" mass="51914" checksum="7A70F35743DEE1B9" modified="2019-05-08" version="1">MEASTQVVASVDALVFDCDGVLWKGESPIPGAVQLINRLQERGKRVFFLTNNSTKSRQMYGEKLRGLGFEARPEQVFGTAPCAALYLKQEARLQGSVYLIGGAALRGELQAQGIACTGSGPGPELTSEPMHVWLAEPLDPAVGAVLVGFDEHFTYMKLCRATRYLRNPACIFLATNTDTLLPLEGGGIPGTGCLVKAVEAAANRTAHVIGKPSTFMFECMVKEHGVDLNRTIMVGDRLDTDILMGSNCGLRTILTLTGVSTLEEVQADHLGAKAGIGLRILWGALLLLVVAAVIGVSAVGILNLRGNNRQVVQITFHDVQGAIISQSAVVNEEEDLVTYHIMDRNHTTVVLFDSKNGFVCYQPGGSNICLVRKMLAVDQENIHTVITAQEQKFNQLLLLRNETQFSRKYLGILSRNKVDPLTLGQHIDSLCNQIPVYWLQESNRPGRQRLIYFCIDICFPNNVCVSVCFYYLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q091</accession>
    <name>A0A401Q091_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0017773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0688 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011833">
        <property type="protein sequence ID" value="GCB78703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q091"/>
    <dbReference type="STRING" id="75743.A0A401Q091"/>
    <dbReference type="OMA" id="FGNVEIM"/>
    <dbReference type="OrthoDB" id="8730115at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031530">
        <property type="entry name" value="UPF0688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28491">
        <property type="entry name" value="UPF0688 PROTEIN C1ORF174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28491:SF1">
        <property type="entry name" value="UPF0688 PROTEIN C1ORF174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15772">
        <property type="entry name" value="UPF0688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="312" mass="35070" checksum="75B39FDC0A4300E6" modified="2019-05-08" version="1">MKTKQVGVRRSARLKNRELCSAASNTPKQDVKDDSSMQKTIVPSHEAMPALDKIVPSPGNHPSKKQKCERVETEEETGTAEQVLEDSAVILPHKPPHKSTEQNEKPIINEDCAEVTPAPLENEAPSTMIVEQRDTEIQVEHVAETEELINKNGPSTEMPIKKVLEVIDEGMVENKEDIEKTVRSVENDTERSNNMEIDQPPTGTSFKVDNSIFLDEDSNQPMPVGKFFGNVEIMQDLPQSVPLLDSVTRREYRRRHFIAKDEEDEELEDRAVGEREGEPRDLPSSENEVPVGTETKVNSLQQNTPDIVEKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1B1</accession>
    <name>A0A401Q1B1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0020178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015934">
        <property type="protein sequence ID" value="GCB79146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1B1"/>
    <dbReference type="STRING" id="75743.A0A401Q1B1"/>
    <dbReference type="OMA" id="ACFNPFI"/>
    <dbReference type="OrthoDB" id="9941925at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001402">
        <property type="entry name" value="Prolrel_pep_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF19">
        <property type="entry name" value="PROLACTIN RELEASING PEPTIDE RECEPTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01018">
        <property type="entry name" value="PRPRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB79146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="356" mass="40193" checksum="E36F09BA8665B51B" modified="2019-05-08" version="1">MTLNASIDNVTMVPLFLGLNLLFELKPLFIPLYTLLVIVACAGNLLLVVHISTTKKLHTTTNFLIGNLAASDLVMCIFCVPVTVSYAFETKGWIFGIFMCYFITLMQSTTVFVSVLSLTAIAVDRYVVVAYPIRQRIRPRYCAYIVAFIWLVSIGVSMPSSLHTNYIDLNQIGYNMIICEEAWVDLDRQRLLYSCIMLLLSYMLPLCAVSISYCAISCNLKKRNVPGAASCSHEKWSKKRRRTFWMLAISVLSFALCWIPLQTVNLIRDIDLNIIDKSYINVIQVSCHLVAMSSACYNPFIYASLHNKFRFQLNNIVCCNKKRANGTISSQTSRLNTCTSLDDRTIISLKGKLSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1L1</accession>
    <name>A0A401Q1L1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011960">
        <property type="protein sequence ID" value="GCB79275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1L1"/>
    <dbReference type="STRING" id="75743.A0A401Q1L1"/>
    <dbReference type="OMA" id="VMIYVNI"/>
    <dbReference type="OrthoDB" id="5872298at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="192" mass="21455" checksum="E3DDD61145C2D7B6" modified="2019-05-08" version="1">MLSNLRLGIVLIFTYLRLGIVLILTYLRLGIVLILTYLRLGIVLTLTDLRLGIVLILTYLKLGMLLILTYLRLGIVLILTYLRLGIVLILTYLKLGIVPILTSLKLGIVLILTYLRLGIVLILTYLRLGIVLIITYLRLGIVLILTYLRLGIVLIPHLPETGHCIDPHLPETGKCIDPHVPETGHCIDPSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1M2</accession>
    <name>A0A401Q1M2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014607">
        <property type="protein sequence ID" value="GCB79240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401Q1M2"/>
    <dbReference type="OMA" id="TAEAQIC"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="445" mass="47749" checksum="589C60229AB6EB16" modified="2019-05-08" version="1" fragment="single">VTYKMLSQFLGIHVNQAKQMLYYYVERKRKENSGAQLHVTYLLSGKAVENGTSCHKVAVVREDQLEAVPRSAEELARLQMSVQPPSRSSNESSGTGKPIVNGNAPVAPKNVPPQPKGIMGMFATKPSAKSHDKEAKGEPVLAKDGESAAPSGSKTTSKGNSFSNFFLKASAKKSSPPPNRAVKEEDPPTKSAAESPEKGEAPERGGCGVKPASEKGGAEERVPANVAAGRKPQAQAQKEKTLAKKEAVGKKQPKDGQSSKKTKRNAALASEAEEPSNKRRRRIKLPQSDSSDDELIPDSPEACDIKTPSPPHDEPIKEEDASPQCLSDVEVKPTCWESADEAAVMSSSSTMKSLSVRIVQLVYAEDNLQQNVTEKVYQSESCTDSESEFAAKQQESKNLSGPKPASMKSAAGGKEQPKEQKEKKAATSSRAGKQVSIMGFFKKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q234</accession>
    <name>A0A401Q234_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0019552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014666">
        <property type="protein sequence ID" value="GCB79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q234"/>
    <dbReference type="STRING" id="75743.A0A401Q234"/>
    <dbReference type="OrthoDB" id="21192at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="113" mass="13078" checksum="753D5B8B8ACD5EC3" modified="2019-05-08" version="1">MNDGVEVCRSNKSPWVCLMCSSVHCGRYVNGHAKKHYEDAQINSNNIKKSEKHEKEKLQHAVCMDCSSYSTYWYVKVKHQVLMQGCNKFFALLLMYTLVCRTGSILIFNAEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2R2</accession>
    <name>A0A401Q2R2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0016016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01009411">
        <property type="protein sequence ID" value="GCB79640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2R2"/>
    <dbReference type="STRING" id="75743.A0A401Q2R2"/>
    <dbReference type="OMA" id="DESXQMI"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000006">
        <property type="entry name" value="guanylate cyclase soluble subunit beta-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF17">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="417"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB79640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="633" mass="72125" checksum="0461F422A18333D1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3G7</accession>
    <name>A0A401Q3G7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemokine interleukin-8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009472">
        <property type="protein sequence ID" value="GCB79908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3G7"/>
    <dbReference type="OMA" id="MRISNIK"/>
    <dbReference type="OrthoDB" id="9948647at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019081942" description="Chemokine interleukin-8-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB79908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="10808" checksum="D407214C51115C3C" modified="2019-05-08" version="1">MVSKTSVTFFSIIALCLVFADAVPRLPTQRRCRCINQAEELQPSMGITNVNIFFKQGLCPNIEIIVNLQNRRICLNPDSKVGKKIIALMRKRMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q466</accession>
    <name>A0A401Q466_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010827">
        <property type="protein sequence ID" value="GCB80175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q466"/>
    <dbReference type="STRING" id="75743.A0A401Q466"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="11663" checksum="C3C466A36477252D" modified="2019-05-08" version="1">MSFSPDPPFYPHLHFSPVSSLSFNLNSLSCQESDTPKRRLKLSPESGNPSPEALPVATDTKTPTDQSPNSPCRLEAMNTDQCQTPVKRTVPKPVSEEKTSVDIVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4M8</accession>
    <name>A0A401Q4M8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="6">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Alpha-ketoglutarate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0018078</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:12189"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01012276">
        <property type="protein sequence ID" value="GCB80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4M8"/>
    <dbReference type="STRING" id="75743.A0A401Q4M8"/>
    <dbReference type="OMA" id="FEICTMA"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF7">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="18">
        <location>
            <begin position="121"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxoglutarate dehydrogenase E1 component/KDG C-terminal" evidence="19">
        <location>
            <begin position="483"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="638" mass="72592" checksum="FEA3B90F42593437" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q674</accession>
    <name>A0A401Q674_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019865">
        <property type="protein sequence ID" value="GCB80868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q674"/>
    <dbReference type="OMA" id="CQINDSG"/>
    <dbReference type="OrthoDB" id="8964756at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052949">
        <property type="entry name" value="PA_immunity-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999">
        <property type="entry name" value="ANTIBIOTIC RESISTANCE PROTEIN MCBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="14558" checksum="0D38D9C26740CFE4" modified="2019-05-08" version="1">MACNDLGLEECQSNESGLKECQSNDSGLEECQINDSGLEECQINDSGLEECQINDSELEEYQINDSGLEECQINDSGLEERQINDSGLEECQINDSELEKCQINDSGLEECQSNDSGLEEYQSNKWGLEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6U0</accession>
    <name>A0A401Q6U0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Hexokinase-2</fullName>
            <ecNumber evidence="6">2.7.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Hexokinase type II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">scyTo_0021326</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Monomer. Interacts with TIGAR; the interaction increases hexokinase activity in a hypoxia- and HIF1A-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.1" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01018693">
        <property type="protein sequence ID" value="GCB81090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6U0"/>
    <dbReference type="STRING" id="75743.A0A401Q6U0"/>
    <dbReference type="OMA" id="SYLVSWT"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000015">
        <property type="entry name" value="Hexokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000001">
        <property type="entry name" value="Hexokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000020">
        <property type="entry name" value="Hexokinase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF4">
        <property type="entry name" value="HEXOKINASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="26">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="27">
        <location>
            <begin position="60"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="26">
        <location>
            <begin position="306"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="27">
        <location>
            <begin position="509"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="28">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="GCB81090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="752" mass="83633" checksum="8ABD03D20D4DC5A6" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6Y7</accession>
    <name>A0A401Q6Y7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">ATP-sensitive inward rectifier potassium channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0022760</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023910">
        <property type="protein sequence ID" value="GCB81132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6Y7"/>
    <dbReference type="STRING" id="75743.A0A401Q6Y7"/>
    <dbReference type="OMA" id="HHIIDKS"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015272">
        <property type="term" value="F:ATP-activated inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000036">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000002">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003268">
        <property type="entry name" value="K_chnl_inward-rec_Kir1.1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF6">
        <property type="entry name" value="ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01321">
        <property type="entry name" value="KIR11CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 15" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="17">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="18">
        <location>
            <begin position="193"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="14">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB81132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44655" checksum="4E85512E16DF380C" modified="2019-05-08" version="1">MEFNVFFGIVFTDQKVFFHGMLKYLRRRFTRNLTERNRQRARLVSKDGRCNIEFGNIKEHSRIGFLVDIWTTVLDLKWRYQMTIFISAFLGSWFLFGLLWYAVAYVHKDLPEFSPTENHMPCVQNINGLTSAFLFSLETQVTIGYGFRCVTEQCGEAIFLLVTQSILGVIINSFMCGAILAKISRPKKRAKTITFSKSAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTLEGETIIMDQVNIDFIVDAGNENLFFISPLTVYHIIDKTSPFYEMSAETIKQQDFELVVFLDGTIEATSATCQVRTSYIPEEVFWGYRFSPIVSKSKEGKYRVDFSNFGKTVQVDTPHCAYCLQTEKEAKLKEKKAYDNPVFQLNEVNETKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Q2</accession>
    <name>A0A401Q8Q2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0021455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019071">
        <property type="protein sequence ID" value="GCB81750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8Q2"/>
    <dbReference type="STRING" id="75743.A0A401Q8Q2"/>
    <dbReference type="OMA" id="INACWEL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB81750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10328" checksum="FB122DF99EB8E570" modified="2019-05-08" version="1">MRECISIHVGQAGVQMGNACWELYCLEHDIQPDGQMTEEKAREEKSRTKDDSNTTFFSHTAFNKYVPRAVFVDLEPTVIGLYMVADFEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAJ3</accession>
    <name>A0A401QAJ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0022660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01023402">
        <property type="protein sequence ID" value="GCB82382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAJ3"/>
    <dbReference type="STRING" id="75743.A0A401QAJ3"/>
    <dbReference type="OMA" id="PVSMAIC"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
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            <begin position="380"/>
            <end position="605"/>
        </location>
    </feature>
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            <end position="113"/>
        </location>
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            <end position="262"/>
        </location>
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        <location>
            <begin position="279"/>
            <end position="358"/>
        </location>
    </feature>
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            <end position="11"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
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            <end position="327"/>
        </location>
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        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB82382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="605" mass="67259" checksum="4C3907F7B23068BE" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401QB47_SCYTO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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    </gene>
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        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
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                <person name="Nakagawa R"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="54" mass="5886" checksum="99BA959A0A5080B3" modified="2019-05-08" version="1" fragment="single">MSTPNINPSVDVFGLGGLCRDDPAFYRYTPAAVVLEQAEIRHGQNEKELSCSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401QCM6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
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                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01036923">
        <property type="protein sequence ID" value="GCB83139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QCM6"/>
    <dbReference type="OrthoDB" id="636773at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF1">
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401QCQ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">scyTo_0023823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034357">
        <property type="protein sequence ID" value="GCB83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QCQ1"/>
    <dbReference type="OMA" id="ACTGPMG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1091">
        <property type="entry name" value="COLLAGEN ALPHA-3(IV) CHAIN-LIKE ISOFORM X1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="109"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="11189" checksum="21D89D849F6184BC" modified="2019-05-08" version="1" fragment="single">GNIGFKGERGLPGTPGLSGIPGDQGPPGPAGVGVTGYPGEKGSQGFPGSAGIAGEAGQKGASGNAVNQPGPRGFPGPPGLTGEPGSRGDPGLPGAPGLHGAIGPKGDPGPTGIGFPGPTGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD84</accession>
    <name>A0A401QD84_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030736">
        <property type="protein sequence ID" value="GCB83287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
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        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="650" mass="68505" checksum="4F4458A21DB845A6" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDW8</accession>
    <name>A0A401QDW8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01044111">
        <property type="protein sequence ID" value="GCB83608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDW8"/>
    <dbReference type="STRING" id="75743.A0A401QDW8"/>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="9335" checksum="2C0125E3FD9A6A78" modified="2019-05-08" version="1" fragment="single">LENERKSEIVQVVKNPLKIKRLKKKQLRKIEKRDTLRILQQSQRQREDGQAKKSFRRRVGARVEGQAERQSARTVNGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEL6</accession>
    <name>A0A401QEL6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01040833">
        <property type="protein sequence ID" value="GCB83810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEL6"/>
    <dbReference type="STRING" id="75743.A0A401QEL6"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="10898" checksum="3152831B987D84A0" modified="2019-05-08" version="1">MCKLVTGCSCRQLECGLFPQKWSGPEKLLALDELIDRCETSQIKYMMQVIEPQFQRDFISLLPKEVRVDVGISTCELLMHNMSETIAFTSHTEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEN3</accession>
    <name>A0A401QEN3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01043498">
        <property type="protein sequence ID" value="GCB83831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEN3"/>
    <dbReference type="STRING" id="75743.A0A401QEN3"/>
    <dbReference type="OMA" id="QVICKHT"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8250" checksum="78D79C945549BDCA" modified="2019-05-08" version="1" fragment="single">LERALTEPQIQVICKHTLEALSYLHDIKVIHRDLKAGNILLTMEGDVKLADFGVSAKNSRTLQRRDSFIGTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIF8</accession>
    <name>A0A401QIF8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01137579">
        <property type="protein sequence ID" value="GCB85136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIF8"/>
    <dbReference type="OMA" id="TTRHQDN"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35684">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="222" mass="22924" checksum="670DB5A2C96AA3CB" modified="2019-05-08" version="1">MAVNILESQCGPNSLSTGVNIPESQCGPNLLSTGVNIPKSQCGPNVLSIGVNIPESQCRPNLLSIGVNIPKSQCGPNLLSTGVNIPQSQCGPNLLSIGVNIPERQCDPNLLSIRVNIPESQCDSNLLSIGVNIPESQCGPNLLPMGVNIPESQCDPNLLSIGVNIPESPCGPNLLSTGVNIAESQCGPNLLSMGVKIPQSHCGPNLLSMGVNIPESPCGPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIL5</accession>
    <name>A0A401QIL5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cholecystokinin receptor type A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholecystokinin-1 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0025819</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01130730">
        <property type="protein sequence ID" value="GCB85214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIL5"/>
    <dbReference type="STRING" id="75743.A0A401QIL5"/>
    <dbReference type="OMA" id="TISRCCA"/>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004951">
        <property type="term" value="F:cholecystokinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000596">
        <property type="entry name" value="Cholcy_rcpt_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF75">
        <property type="entry name" value="CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00524">
        <property type="entry name" value="CCYSTOKNINAR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB85214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="144" mass="16350" checksum="617DD8BC8F13FC05" modified="2019-05-08" version="1">MEMATLTPSTSAKLDRVRSNASESKLVAKKRVIRMLIVIVVMFFVCWMPVYTVNTWRAFDDLNAIRQLSGAPISFIHLLSYTSSCVNPLVYCFMNKRFRKAFLSTFSRCLRPLRVFKDLEEEPGTTGTSMSKFSYTTVSTVGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIX0</accession>
    <name>A0A401QIX0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01139496">
        <property type="protein sequence ID" value="GCB85320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIX0"/>
    <dbReference type="STRING" id="75743.A0A401QIX0"/>
    <dbReference type="OMA" id="WFMAKRD"/>
    <dbReference type="OrthoDB" id="9048614at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883:SF12">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47883">
        <property type="entry name" value="YIPPEE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="18979" checksum="4EF2AD50DA6AD8DC" modified="2019-05-08" version="1">MAVQSNQDPEVQAVQCNLEPEAMAVQSNLEPEAQAVQSNLEPEAKAVQSNQDPEVQAVQCNLEPEAQAVQFNLEPEAQAVLFKLEPEAQAVQSSLEPEAQAVQSNLEPEAQAVQSNQEPEAQAVQSNLEPEAQAVQSKLEPDAQAVQSNLEPKAHAVQSNLEPEAQAMQNKLEPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ95</accession>
    <name>A0A401QJ95_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01149836">
        <property type="protein sequence ID" value="GCB85433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ95"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="157" mass="18537" checksum="253CE6F47A0F1157" modified="2019-05-08" version="1" fragment="single">WHQEKHRRKKRWKRIRRKKRKSSSESSEFSSEDVKLVESEEEEEGQEEEESPVKARQVEPKKRRVRCWNPVQSIVLDVDRWVPVVESKPVPARESDSRQGCDSVTVKMEGQNRPGRPKSSKIWRNLSCGDRALPKAREPEKKLIEVRVLNRRNGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJE4</accession>
    <name>A0A401QJE4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01161745">
        <property type="protein sequence ID" value="GCB85483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJE4"/>
    <dbReference type="STRING" id="75743.A0A401QJE4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="11980" checksum="9CFED5B15ADD250F" modified="2019-05-08" version="1">MKQDEGGLRRVKEEEGGLKRVKQDEGGLKRVKHDDGGLKTVKQDEGGLKRVKQDEGGLKRVKEDEGGLNRVKLDEGGLKRVKQDEGGLKRVKQDEGRLKRVKYEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJH5</accession>
    <name>A0A401QJH5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01172453">
        <property type="protein sequence ID" value="GCB85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJH5"/>
    <dbReference type="STRING" id="75743.A0A401QJH5"/>
    <dbReference type="OrthoDB" id="9944211at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="12609" checksum="32475C1B8B615200" modified="2019-05-08" version="1">MGLSDMFRLANRIACNPGVLLSPPQAKGVFEKVGEATETALVCLVEKMNVFNTDVRSMTKVERANACNSVIKQLMKKEFTLEFSRDRKSMSVFCSPAKASRAAVGNKMFIKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJQ9</accession>
    <name>A0A401QJQ9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01174199">
        <property type="protein sequence ID" value="GCB85558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJQ9"/>
    <dbReference type="STRING" id="75743.A0A401QJQ9"/>
    <dbReference type="OrthoDB" id="7976202at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="63" mass="7192" checksum="843780697C758B49" modified="2019-05-08" version="1" fragment="single">YFKQIVKSARTNAAAGSQEENDDFLGCLDIPLSVSLTDRTEDWNRLPEQCTMQSWFISRHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJY4</accession>
    <name>A0A401QJY4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0026356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01187200">
        <property type="protein sequence ID" value="GCB85684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJY4"/>
    <dbReference type="STRING" id="75743.A0A401QJY4"/>
    <dbReference type="OMA" id="KLMQWLF"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB85684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10173" checksum="3CF4F85CD4720423" modified="2019-05-08" version="1">MTKLAEWLLGLALLGGGWATLTFDPLGLRLPLAGRQLLWPLPAYLLVAFGCYSLATVGYRLATFNDCRGASEELQTQIQEARRDLAARGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKD9</accession>
    <name>A0A401QKD9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01214299">
        <property type="protein sequence ID" value="GCB85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKD9"/>
    <dbReference type="STRING" id="75743.A0A401QKD9"/>
    <dbReference type="OMA" id="VEICIQP"/>
    <dbReference type="OrthoDB" id="6382204at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="326" mass="35698" checksum="9228607D62E513B0" modified="2019-05-08" version="1" fragment="single">LLKEGPNSSLLKGVPNSSLFKGGVKLIAIESGAKLIAIQRGVKLIAIESGAKLIAIERSARLITIERSAKRIATERSAKRIAIQRGVKLFTIERGVKFITIERSAKLIATERTAKLNEIERSAKPIAIQRSAKLIAIERSAKLITIERGAKLIAIERRAKLFTIERGAKFIAIERNAKLSAIERSAIFIAIQRSAKLIPIERSAKLIAIERSAQLITIERGVKHIAIESGAKLIAIESGAKLIAIERSARLITIKRSAKLIATERSAKLSTIERSAKLIAIERSAKLIAIERSAKLIAIERSAKLIAIERSVKLIAIERSAKLIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QN66</accession>
    <name>A0A401QN66_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01340126">
        <property type="protein sequence ID" value="GCB86748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QN66"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="56" mass="7367" checksum="65564B23396B4564" modified="2019-05-08" version="1" fragment="single">MSERERGERASEYESREDEYESREGEYERREGEYERREGEYERREREYERREREYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNC8</accession>
    <name>A0A401QNC8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01368094">
        <property type="protein sequence ID" value="GCB86875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNC8"/>
    <dbReference type="OMA" id="GIWEKEN"/>
    <dbReference type="OrthoDB" id="6418646at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="93" mass="10912" checksum="3603819FA52EEA45" modified="2019-05-08" version="1">MKENGIWVKENGTRVKENGIWEKENGTRVKENGTRVKENGIWVKENGIWVKENGTWVKENGIWVKEYGIWVNDNGIWVNDNGIWVKENGIWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPL7</accession>
    <name>A0A401QPL7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0028000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01447899">
        <property type="protein sequence ID" value="GCB87268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPL7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="145" mass="14292" checksum="00029CDD89AD4819" modified="2019-05-08" version="1" fragment="single">MTVVAVVGEEVVDADVAVGITVVAVVGEEVVDADVVGGMTVVAGVGEEVVDADDVGMSVVDGIGEEVVDADVVGMSVVDGIGEEVVDADDVGMTVVDGIGEEVVDADVVVGITVVAVVGEEVVDADVVVGMTVVVEEVVNADVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGA2</accession>
    <name>A0A401NGA2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007423">
        <property type="protein sequence ID" value="GCB59950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGA2"/>
    <dbReference type="STRING" id="75743.A0A401NGA2"/>
    <dbReference type="OrthoDB" id="29546at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09490">
        <property type="entry name" value="SAM_Arap1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052227">
        <property type="entry name" value="Arf-Rho-GAP_ANK-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899:SF1">
        <property type="entry name" value="ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB59950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="357" mass="39515" checksum="19E46790DB2EB9CE" modified="2019-05-08" version="1" fragment="single">MLSSSEASGDIADWLISIHLEQYADHFKQSGYFTVGDCKHLNNEILLHIGIVPTGHRKRILKHLSSVFPEADVSIVSKSPEKLLLESDNQGFALHNLTKISDRKVEETEKSIPVSKLRTMFAKGGLTSDCADPVNIDGCINSKNKIPTPPMQGFEVQQKFPVGKNLKGAFEPDDPSFNSCDPYDDVGNRPPLPPRVHHGTPPFKFTAESMLLPYDSVDSSNISITNEQATLVEMQSLTSTPPDLPLFEFQGKMVLNDLYDGWLDSSEQVTSCPLKASDLRNRPVPQRPGPYAAHGVTLHCTENSSLLKRRNLNLSHITSNDIPQSMLSAGMCTDENKASPISPYGETFLYHRPEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGJ2</accession>
    <name>A0A401NGJ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetochore-associated protein DSN1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006184">
        <property type="protein sequence ID" value="GCB60029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGJ2"/>
    <dbReference type="STRING" id="75743.A0A401NGJ2"/>
    <dbReference type="OMA" id="QDKSQSW"/>
    <dbReference type="OrthoDB" id="10044040at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40826" checksum="9E7EA4F7E32CD8CD" modified="2019-05-08" version="1">MEEGGSVKKRLRNSNQNTSLSQSSSPKRKCIKQQKPGNPEHVAKQEETPPSSSPLTRRSARLNPGRCADASLTPQEHDHANPTCHTKMSPASPSKEPEVSKAPSPNKQAKKSLLSQSWRRSSLKGGKGRKSLPPIHQDSTEICEGIRMDLPEDERLALLLQACLEYTLQKLQRTLETREDFSLEAFQTHVSGISNDVKRVVETMKIDGTLKKCTEKPDDVLPAPETEIMMKQLKDDIARLNAECKAWDRLLDVYQQNINAASDLGKVAVAGETLEPVMMMENSQIDVIKTKPDYRCYFDEDVTILQNMECIMDQLQLTMNLITRDRQEWDSSLQSISEELASRTFKGLEECPLQKFLTVMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIP3</accession>
    <name>A0A401NIP3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal biogenesis factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxisomal assembly protein PEX3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0009223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PEX19.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003707">
        <property type="protein sequence ID" value="GCB60727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIP3"/>
    <dbReference type="STRING" id="75743.A0A401NIP3"/>
    <dbReference type="OMA" id="HATCSET"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB60727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="303" mass="34312" checksum="2DFD2792CB041D12" modified="2019-05-08" version="1">MLPSLWSFIKRHKRKFLFTGAFVGGVYLLGKYAQKKIRDLQEQEAAEYIAQARRQYHFESNQRTCNMTGKNTFVTVRKLFFLPEGAPLAPPEVQQQYLSSIQHLLGDGLNELITVVKKAVQNVIGNVSLKQCVSLQELERYLGEIRQLVEHRGQSSEPETGSPLCWYLIPNEESTLASQACGLTEKDVTTLKLLNETRDMLESPDFNTVLNSCLNRGFSRLLDNMAEFFKPTEQELAQNGKINSLSNIQLPLAKIIPIINGQIHSTCSETPSHFVQDLLLMEQVKDFAANVYEAFSSPQQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ08</accession>
    <name>A0A401NJ08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0012811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01006309">
        <property type="protein sequence ID" value="GCB60849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ08"/>
    <dbReference type="STRING" id="75743.A0A401NJ08"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF22">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="201"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="330"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB60849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="670" mass="76284" checksum="E9CCFF945DD3166D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJQ2</accession>
    <name>A0A401NJQ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">StAR-related lipid transfer protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">START domain-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0011250</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with ATAD3A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005047">
        <property type="protein sequence ID" value="GCB61092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NJQ2"/>
    <dbReference type="OMA" id="WRYHCTE"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000005">
        <property type="entry name" value="Kinesin family member 16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000021">
        <property type="entry name" value="kinesin-like protein KIF16B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000022">
        <property type="entry name" value="StAR-related lipid transfer (START) domain-containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF1">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="18">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="19">
        <location>
            <begin position="4349"/>
            <end position="4471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="765"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1053"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1966"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2032"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2364"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2420"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3117"/>
            <end position="3136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3399"/>
            <end position="3419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3888"/>
            <end position="3917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3983"/>
            <end position="4011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="4154"/>
            <end position="4192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2032"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="3899"/>
            <end position="3914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="4001"/>
            <end position="4011"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB61092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="4491" mass="501675" checksum="BF25CBBC6968287A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJU0</accession>
    <name>A0A401NJU0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006356">
        <property type="protein sequence ID" value="GCB61146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJU0"/>
    <dbReference type="STRING" id="75743.A0A401NJU0"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF54">
        <property type="entry name" value="ANKYRIN-3-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB61146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="14468" checksum="BE18953237E88182" modified="2019-05-08" version="1">MSETSSISSGSTVGSGSRVLQLASKGDWCVLEQSLKSMDKGDRDITLTDEESGLTPLLIAVRESKLTIVERLFELGANQNDRSKDGRSALHIAAAHSKDEIVRLLLAKKLDPNLTGGVWIQLLYRQCALLICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQY4</accession>
    <name>A0A401NQY4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division cycle 40 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PRP17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0004378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001299">
        <property type="protein sequence ID" value="GCB63234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQY4"/>
    <dbReference type="STRING" id="75743.A0A401NQY4"/>
    <dbReference type="OMA" id="VQVYDHH"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB63234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="581" mass="65582" checksum="C867E0731CE277DC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT87</accession>
    <name>A0A401NT87_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0014721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008008">
        <property type="protein sequence ID" value="GCB64080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT87"/>
    <dbReference type="STRING" id="75743.A0A401NT87"/>
    <dbReference type="OMA" id="MANCFRA"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB64080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="613" mass="70428" checksum="0CDA8B0D076BE9CA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU15</accession>
    <name>A0A401NU15_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002744">
        <property type="protein sequence ID" value="GCB64347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU15"/>
    <dbReference type="OrthoDB" id="9424252at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028040">
        <property type="entry name" value="TopoVIB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14652">
        <property type="entry name" value="TYPE 2 DNA TOPOISOMERASE 6 SUBUNIT B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14652:SF2">
        <property type="entry name" value="TYPE 2 DNA TOPOISOMERASE 6 SUBUNIT B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15091">
        <property type="entry name" value="DUF4554"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="487" mass="54688" checksum="A71AB12846E1FBC5" modified="2019-05-08" version="1">MESADLNEKINSPGLKMTFEISETSRIVMTDCLTIERFLHRIGIVNENLDKFCRDGHTVLCDSTHYVTDFAYADDSHCCRLHPIAGKPFPLSIPNKLAEDGVCGVLEILSIAAICPCLKNYPNKPTRVSNVSVSFVESALITLKLTGLACPDISYTLRSILEDDCSERGDTQGQKLLLFLFIKYWDDFHLELVDVTGQQAIVDHLDQILHYNKDVVRKSIQPVLHQVLDEYLRFKKNQGRIQTATTVICDALQSILSMSTNRDFRAKSLQLLKVSSTQEMKTSLQNTLQNIVQNRFLPSRVCYTKRVHSGDGDRVQSNTDSASPGASQENRRDTAQVQRIHAELSHSESDPSFTLVDSDGLDWSADPPQVSAETDSHFGSFERRIGTRKRQLEADRMKPGTNPASSPFKKPVDGSYSQPRLENVSTGHISSRKPGVQVSIPPRLTSETTDSFGVQCSPKQTINRKPTEDQEEYLWLREVSNLSDWTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU45</accession>
    <name>A0A401NU45_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine palmitoyltransferase small subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein ADMP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Small subunit of serine palmitoyltransferase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0007529</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity. SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SPTSS family. SPTSSB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002747">
        <property type="protein sequence ID" value="GCB64377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU45"/>
    <dbReference type="STRING" id="75743.A0A401NU45"/>
    <dbReference type="OMA" id="NFKNMRE"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28612">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28612:SF1">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB64377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="9082" checksum="79E9C2EBDAB0D05F" modified="2019-05-08" version="1">MDVKGVKDTLSWLFYQYLLVTCSYVLEPWEQTVFNSVLLIIVAMVLYTAYVFIPIHIRLALEFFSGLGAGQLESTVAIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUX8</accession>
    <name>A0A401NUX8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006799">
        <property type="protein sequence ID" value="GCB64688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUX8"/>
    <dbReference type="STRING" id="75743.A0A401NUX8"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="290" mass="31246" checksum="56AB3DB39CFE07B2" modified="2019-05-08" version="1">MATDCTAEPDMEAAKEGESAPDPPAGLIGPAEQASSSEGQGDGGEPLAKVARLANDEGSPRLLAADLAERLEGCEAPAAPDRPATSDLPATPDLPVTSDLGSPPRDAGGQSAEAEEETQGDREAEYCPDHLEPDTRSEAETVLGREHEAPQCTESDTVYYQAGYDFTQQPQLLSGAWKEYTGVAENFLKGCKWAPDGSCILTNSADNTLRIYNLPSELYNREWDDLPEMSVLRQLVVTVVCDSPRAAEPLAFADRRLRAEAASVEEKDRRFTQIHVQGESRQQQLADDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV90</accession>
    <name>A0A401NV90_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0011797</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005490">
        <property type="protein sequence ID" value="GCB64762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NV90"/>
    <dbReference type="STRING" id="75743.A0A401NV90"/>
    <dbReference type="OMA" id="VVRFPXK"/>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06624">
        <property type="entry name" value="STKc_ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000054">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000067">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046872">
        <property type="entry name" value="DRHyd-ASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046873">
        <property type="entry name" value="HisK-N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043969">
        <property type="entry name" value="MAP3K_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025136">
        <property type="entry name" value="MAP3K_TRAF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF332">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19039">
        <property type="entry name" value="ASK_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20309">
        <property type="entry name" value="DRHyd-ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20302">
        <property type="entry name" value="HisK-N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13281">
        <property type="entry name" value="MAP3K_TRAF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="657"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1150"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1155"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1174"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB64762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1265" mass="142163" checksum="8DB7FEFA91290EAD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVG9</accession>
    <name>A0A401NVG9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0009887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004147">
        <property type="protein sequence ID" value="GCB64878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NVG9"/>
    <dbReference type="OMA" id="NQRDCHS"/>
    <dbReference type="OrthoDB" id="1939715at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009738">
        <property type="entry name" value="BAT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033184">
        <property type="entry name" value="PRRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038">
        <property type="entry name" value="BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038:SF4">
        <property type="entry name" value="PROTEIN PRRC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07001">
        <property type="entry name" value="BAT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAT2 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1261"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1422"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1482"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1640"/>
            <end position="1680"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1713"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1965"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="488"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="567"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="658"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1353"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1640"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1730"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1755"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1793"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1845"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1977"/>
            <end position="1990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB64878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2271" mass="250508" checksum="7C1A14A3405ABA6E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW38</accession>
    <name>A0A401NW38_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001414">
        <property type="protein sequence ID" value="GCB65098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW38"/>
    <dbReference type="STRING" id="75743.A0A401NW38"/>
    <dbReference type="OMA" id="PMGDKPG"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019466670" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="19843" checksum="7DE7130913B3BC4C" modified="2019-05-08" version="1">MLLEWWCGVQVRLLEWWCGVQVRLLGWWCGPQLRLLEWWCGAPGEAPGVVVRAPDEAPGVVVRAPGDAPGVVVWSPDEAPGVVVRAPDEASGVVVRAPDEASGVVVRAPDEAPGVVVRAPGEAPGVVVRAPDEAPGVVVRAPGEAPGVVVRAPGEAPGVVVWSPGEAPGVVMWGPGEAAHVLGQDSGKAAGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW80</accession>
    <name>A0A401NW80_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 25 member 32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitochondrial FAD transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0000382</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FAD(in) = FAD(out)</text>
            <dbReference type="Rhea" id="RHEA:76535"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000070">
        <property type="protein sequence ID" value="GCB65130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW80"/>
    <dbReference type="STRING" id="75743.A0A401NW80"/>
    <dbReference type="OMA" id="QLIYREE"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015711">
        <property type="term" value="P:organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000025">
        <property type="entry name" value="mitochondrial folate transporter/carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="121"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB65130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="316" mass="35346" checksum="15F305A95E00B418" modified="2019-05-08" version="1">MSSGAGQAPELSWTAAALRLFQLVKYENLVAGVSGGVLSTLVLHPLDLVKIRFAVSDGLRMRPKYNGIVHCIRSIWKQDGIRGLYQGVTPNVWGAGLSWGLYFFFYNAIKAYKQDGRSAQLSATQHLISAAEAGVVTLCITNPIWVTKTRLVLQYDAGVNPSKRQYKGMLHALLKIYQIEGIRGLYKGFVPGLFGTSHGALQFMAYEELKKEYSQYKKMAPDAKLNPLEYVTMAALSKVFAVTATYPYQVVRARLQDQHTQYSGVMNAVWRTWRNEGVHGFYKGVLPNVLKVTPACCITFLVYENVSQFLLDFHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWX1</accession>
    <name>A0A401NWX1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0011864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005556">
        <property type="protein sequence ID" value="GCB65366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWX1"/>
    <dbReference type="STRING" id="75743.A0A401NWX1"/>
    <dbReference type="OMA" id="KYPQKIP"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000149">
        <property type="entry name" value="microtubule-associated proteins 1A/1B light chain 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB65366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15282" checksum="B1BC16DB46D7C2E7" modified="2019-05-08" version="1">MRGMAVVHRTHGAQRFKHRKTFAARKEESTFIRSKYPQKIPVIVERYHGERHLKSLDKTKYLVPQDVIVSHFITIIRNRLALTPNQAFYLVVRNKSLSNMYATIAELDQEFQDSDGFLYISYASQEMFGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXJ2</accession>
    <name>A0A401NXJ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0004816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001447">
        <property type="protein sequence ID" value="GCB65592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXJ2"/>
    <dbReference type="STRING" id="75743.A0A401NXJ2"/>
    <dbReference type="OMA" id="MENRCTK"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02896">
        <property type="entry name" value="complement_C3_C4_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.130.20:FF:000001">
        <property type="entry name" value="Complement C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000155">
        <property type="entry name" value="complement C3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1940:FF:000001">
        <property type="entry name" value="Complement component C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041425">
        <property type="entry name" value="C3/4/5_MG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048848">
        <property type="entry name" value="C3_CUB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF81">
        <property type="entry name" value="COMPLEMENT C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21308">
        <property type="entry name" value="C3_CUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17790">
        <property type="entry name" value="MG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="4">
        <location>
            <begin position="361"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="5">
        <location>
            <begin position="611"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB65592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1228" mass="136797" checksum="65684C36924EF891" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY30</accession>
    <name>A0A401NY30_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CP072 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0004856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001459">
        <property type="protein sequence ID" value="GCB65764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY30"/>
    <dbReference type="STRING" id="75743.A0A401NY30"/>
    <dbReference type="OMA" id="NSFEEEC"/>
    <dbReference type="OrthoDB" id="5823474at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040308">
        <property type="entry name" value="HAPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31624:SF4">
        <property type="entry name" value="CHROMOSOME 16 OPEN READING FRAME 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31624">
        <property type="entry name" value="UPF0472 PROTEIN C16ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB65764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30809" checksum="B59EC5022C7E1F52" modified="2019-05-08" version="1">MEDKRDEHESEMQEHCPEHWFSKWERQCLAESEQEEQSQEERASLEEEQTQQKLWHLFQNSATAVAQLYKDRVCQQQGLSLWVPFQNAASAVTNVYKESIEAHRRSCDLGIQVGYQRRNKDVLAWVKKRRRTIRREDLISFLCGKAPPPRNTRAPPRLTVVTSPTRAPTTETSSSVETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSGSSNSSRRRNGLHDVDLNTFISEEMALHLDNGGTRKRTSAQCTDVITDSPTHKRNRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYL9</accession>
    <name>A0A401NYL9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0000519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000095">
        <property type="protein sequence ID" value="GCB65966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYL9"/>
    <dbReference type="STRING" id="75743.A0A401NYL9"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF236">
        <property type="entry name" value="PROTOCADHERIN GAMMA-C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="51"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB65966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="175" mass="18208" checksum="8821A450D5318B90" modified="2019-05-08" version="1">MFQIQAQVRDAGVPPLSSSATLNVIILDQNDNAPVIVSPSAQSGSAGVEVVPQSAGQGYLVTKIIATDADSGQNARLLYQILESTDPSLFSVAGNSGDIRTNRSILEQDGPTCLLVFLVMDNGQPSPSTTATIFLSILANVSEEASANGNLDTAPGYSIDRDIYLVAAFGSTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ28</accession>
    <name>A0A401NZ28_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008257">
        <property type="protein sequence ID" value="GCB66162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ28"/>
    <dbReference type="OMA" id="SIDHDTK"/>
    <dbReference type="OrthoDB" id="6092352at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="226" mass="25877" checksum="1672CF4AD79FFA93" modified="2019-05-08" version="1">MNECRRTSQVLSTTAASLISELTESEAAVFELPPWLALIEAKNTTELRFRQKLRESKDTIQTLKATFTNLQKTMAKLTQRRLLLKKENRTIRMGAILQLLDISPEVDFGTMIDSIDHDTKVLEPPKHPPLWFTILKNESFEFGTPEETNPLLQKLAFFHHFTASSVPSAEEKLCLLAVSLPAHQLLKLAVQDALLFIVQCIFKCSSRHVKQWFQYRKLPFTLLCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0W2</accession>
    <name>A0A401P0W2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0000639</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Postsynaptic cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the LRRTM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000122">
        <property type="protein sequence ID" value="GCB66751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0W2"/>
    <dbReference type="STRING" id="75743.A0A401P0W2"/>
    <dbReference type="OMA" id="FHLCEDA"/>
    <dbReference type="OrthoDB" id="5984255at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000005">
        <property type="entry name" value="leucine-rich repeat transmembrane neuronal protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF120">
        <property type="entry name" value="LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019273867" description="LRRCT domain-containing protein" evidence="13">
        <location>
            <begin position="38"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="14">
        <location>
            <begin position="315"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB66751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="525" mass="59196" checksum="54C3C55F376A43D8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0Y5</accession>
    <name>A0A401P0Y5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0005029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Endoplasmic reticulum membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
            <orientation evidence="1 5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001523">
        <property type="protein sequence ID" value="GCB66764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0Y5"/>
    <dbReference type="STRING" id="75743.A0A401P0Y5"/>
    <dbReference type="OMA" id="CGYFNPS"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="7">
        <location>
            <begin position="258"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="415" mass="47258" checksum="8374B2CE3DC1B4C2" modified="2019-05-08" version="1">MGVMLSCWRAKPSTIEVLEKIDKEINALEEFKEKNQRLQKIWVGRLVLYSSTLYIITFIIVYLWCFPEEWTARLTLALPGFLFPLLVWLIRKILIWLFCKRTERNTEALEDLKVQKKKILEEVMEKETYKNAKLILERFDPESKKAKELDQLTSGMPATPRPGQELRQRTSTQRGQVPSTPQDLKQGNPQALQTATPVPQLSTSAPGGPPEKTFQSVSHTPVLARRTMPPATSMPGMGLHPPGPPLARPILPRDRGAVDRIIEYLVGDGPQNRYALICQQCFSHNGMALKEEFEYVAFRCAYCFFLNPARKTRPQAPRLPDFNFEKRPRRDSQSSVGSQSAIIDGQPANEQNEVTEDQNVASLHNSNEVETDKEEPPTPVEIELRDDKEMEQGEQPKENVNDMEMSKDEESPVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1I4</accession>
    <name>A0A401P1I4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dual serine/threonine and tyrosine protein kinase</fullName>
            <ecNumber evidence="5">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Dusty protein kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Receptor-interacting serine/threonine-protein kinase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0005057</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01001538">
        <property type="protein sequence ID" value="GCB66963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1I4"/>
    <dbReference type="STRING" id="75743.A0A401P1I4"/>
    <dbReference type="OMA" id="WRIMTTS"/>
    <dbReference type="OrthoDB" id="122279at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044344">
        <property type="term" value="P:cellular response to fibroblast growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13975">
        <property type="entry name" value="PKc_Dusty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000244">
        <property type="entry name" value="Dual serine/threonine and tyrosine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051302">
        <property type="entry name" value="Dual_SerThr-Tyr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392">
        <property type="entry name" value="DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392:SF1">
        <property type="entry name" value="DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="656"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB66963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="931" mass="104639" checksum="CF37D402CDFC52F2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1N4</accession>
    <name>A0A401P1N4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">A disintegrin and metalloproteinase with thrombospondin motifs 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0010183</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004340">
        <property type="protein sequence ID" value="GCB67024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1N4"/>
    <dbReference type="STRING" id="75743.A0A401P1N4"/>
    <dbReference type="OMA" id="DLCNMTP"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1620.60:FF:000003">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000048">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013274">
        <property type="entry name" value="Pept_M12B_ADAM-TS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF40">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01858">
        <property type="entry name" value="ADAMTS1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="16 21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 24" id="KW-0732">Signal</keyword>
    <keyword evidence="11 19 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019092336" description="A disintegrin and metalloproteinase with thrombospondin motifs 1" evidence="24">
        <location>
            <begin position="24"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="25">
        <location>
            <begin position="223"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="18 22">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="19">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 22">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 22">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 22">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="21">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="327"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="344"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="536"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="540"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR613274-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB67024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="946" mass="103614" checksum="B54282A8797962FF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3I3</accession>
    <name>A0A401P3I3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glypican-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0012180</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Cell membrane</location>
            <topology evidence="2 16">Lipid-anchor</topology>
            <topology evidence="2 16">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glypican family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005802">
        <property type="protein sequence ID" value="GCB67699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3I3"/>
    <dbReference type="STRING" id="75743.A0A401P3I3"/>
    <dbReference type="OMA" id="CEDEEWA"/>
    <dbReference type="OrthoDB" id="10010764at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019803">
        <property type="entry name" value="Glypican_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF8">
        <property type="entry name" value="GLYPICAN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01207">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13 16" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="14 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB67699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="355" mass="40615" checksum="F06FD738B684CDB9" modified="2019-05-08" version="1">MEDNLTKRSRSEFEALVRNASRAVQVMLTAQYNSFDGYFKELLDHSEKNLLRKLSPMHGLLCFDNSKIFKDLFSELLHYYKGGSINLEDVLNEFWSRLMECQFKHQNPHSQISDEYLECMVKHAEQLRPYGEVPRFFKLRLTRVFIAARSFVRSLSLGTEVVKKVSQVPPSPECIRAMMRLMYCPHCRSMASVKPCNNYCLNILKGCLANQADLDSEWRNLIDSMIQVADRFNGPSNLESLVDTIFLKITEAVQTMIDNRARISSKVLQGCGNLKSVSKRSVDDDAKKRGKPYPVEERPVSLVTPAVDRLVTEVKMKLRDVKELWVTLPSALCSEKVTAGSANEDRCWNGQSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3X3</accession>
    <name>A0A401P3X3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0008127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003055">
        <property type="protein sequence ID" value="GCB67829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3X3"/>
    <dbReference type="STRING" id="75743.A0A401P3X3"/>
    <dbReference type="OMA" id="KECNSAT"/>
    <dbReference type="OrthoDB" id="5593455at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF8">
        <property type="entry name" value="F-BAR DOMAIN ONLY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="545"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB67829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="814" mass="87306" checksum="F5A0E30E3E9A6C16" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P432</accession>
    <name>A0A401P432_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Interferon alpha-inducible protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0008139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003061">
        <property type="protein sequence ID" value="GCB67884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P432"/>
    <dbReference type="STRING" id="75743.A0A401P432"/>
    <dbReference type="OrthoDB" id="9948818at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF25">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB67884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20466" checksum="98F0E1DA6F2A33C0" modified="2019-05-08" version="1">MNRRRRAHFPHPTSSPVPDHKQTSSKTTIGSPDCFHTRKTQSCVTLIQDYCHITAAMFRGTLSFFITYLLFSSTFATTDPPLDEDDSCGFIDALPYIVTGGGVAVFAGPAFLAALGFTPQGIAATSIGAAMMKIGAWWNGGGVAAGGLVATFQSLGAKAGTSSLGWLGAKAGYHYHKYVVCEKHQKSTSTDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4A4</accession>
    <name>A0A401P4A4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01004427">
        <property type="protein sequence ID" value="GCB67964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4A4"/>
    <dbReference type="STRING" id="75743.A0A401P4A4"/>
    <dbReference type="OMA" id="DFENHNG"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB67964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="13916" checksum="B12F5C3806261185" modified="2019-05-08" version="1">MVPKTAENFRQLCLKERGSGYKGSVFHRIIPSFMCQGGDFTNGNGTGGKSIYGSKFEDENFTLLHEKEGKISLLPVLDGDLMKNLLNGKHVVFGTVVDGMDIVRMMDGKGSKSGKPSAVVSIADCGELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4S7</accession>
    <name>A0A401P4S7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005850">
        <property type="protein sequence ID" value="GCB68117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4S7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="17556" checksum="DF893D30F236CB1B" modified="2019-05-08" version="1">MDTTITRENTTHQVRGTYSCDSANNVSISVKCVERARVHEEEEHGKSRRPEKAGAQGQQGFRLSKSMEREGEWREQEHRESMCIERAGVRREQEYGESSRLKRAWSEQEYGENKSTERVGVRRAQERGKSRRTERAESETEQEHIKNRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P514</accession>
    <name>A0A401P514_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Grh/CP2 DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0005270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001624">
        <property type="protein sequence ID" value="GCB68229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P514"/>
    <dbReference type="STRING" id="75743.A0A401P514"/>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="188" mass="22343" checksum="9FAC56F95D0E617F" modified="2019-05-08" version="1" fragment="single">MLFWHTQPEHFHHRQHHTATNYLRDALTFPVFKHDESNLPSGNGAKLLPFQYVLCTATSPAVKLHEETLTYLNQGQSYEICMFDNREPGDGQEIIDKYIKSIIRVVFHDRRLQYMEHQQLEGWRWSRPGDRILDMGSLYHCQIKVFKPKGADRKQKTEREKIEKRTVQEREKYQHSCDTTILTQMLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5P9</accession>
    <name>A0A401P5P9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007218">
        <property type="protein sequence ID" value="GCB68426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5P9"/>
    <dbReference type="STRING" id="75743.A0A401P5P9"/>
    <dbReference type="OMA" id="NESSMHE"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="408" mass="43686" checksum="3BB86AB587CD33DC" modified="2019-05-08" version="1" fragment="single">PSTESDEEIQLQIALSLSKEENEKELRVRSSLDEDDEEADENLQRALEQSRKENEIAEGRNESSMHELADIFGAPVTVMETRADPWDTCPQPWRSRNMASPPSTACPELWNTLGTNASIPSTATSWPSLDTNAAASPQMWDTDLWAQPPGPAATTQSSVDPWVTVSTTNTSSVLPESSTFDPFTNPGNSALDQFAESAWVHSAPTLSDSPAGKMDLLGEMIPNTKQNGSSSPDVFDMIEVGHSLKDSSNGPHRTPELFLDPNAASLVNLDSLLSAPSHTLKSKNPFHTSGGLGSISTSNPFQHSQQNKLTLKQIQGNAGFDQPTIMGSATAGMGMASMPFIAPLPMASSCMSTTMTHPSTFSGLAQRPGMMPATRMAVDIGHHFGQPLVPVSKAAVMPQPTTSLNPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5T2</accession>
    <name>A0A401P5T2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="17">ATP-PFK</shortName>
            <shortName evidence="17">Phosphofructokinase</shortName>
            <ecNumber evidence="17">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0005313</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17 18">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="17">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17 18">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homo- and heterotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01001639">
        <property type="protein sequence ID" value="GCB68494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5T2"/>
    <dbReference type="STRING" id="75743.A0A401P5T2"/>
    <dbReference type="OMA" id="LMECVDM"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00764">
        <property type="entry name" value="Eukaryotic_PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000001">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000043">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase, platelet type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041914">
        <property type="entry name" value="PFK_vert-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF14">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 17" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17 18" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="402"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="17">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="17">
        <location>
            <begin position="401"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="292"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="298"/>
            <end position="301"/>
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        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="527"/>
            <end position="531"/>
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        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="565"/>
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        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="572"/>
            <end position="574"/>
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        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
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        </ligand>
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    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="654"/>
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        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="660"/>
            <end position="663"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045436"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB68494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="780" mass="85305" checksum="AB33F50B3631426F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6P6</accession>
    <name>A0A401P6P6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein FAM171A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0010456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM171 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004514">
        <property type="protein sequence ID" value="GCB68811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6P6"/>
    <dbReference type="STRING" id="75743.A0A401P6P6"/>
    <dbReference type="OMA" id="GRWHHES"/>
    <dbReference type="OrthoDB" id="8762914at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043149">
        <property type="term" value="P:stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018890">
        <property type="entry name" value="FAM171"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049175">
        <property type="entry name" value="FAM171_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048530">
        <property type="entry name" value="FAM171_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31626:SF1">
        <property type="entry name" value="PROTEIN FAM171A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31626">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20771">
        <property type="entry name" value="FAM171A1-2-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10577">
        <property type="entry name" value="FAM171A1-2-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="137"/>
        </location>
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            <end position="94"/>
        </location>
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            <end position="661"/>
        </location>
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        </location>
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        </location>
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        <source>
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        <source>
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        </source>
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        </source>
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    <sequence length="663" mass="74078" checksum="BF41C5761F5EB8F8" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Tatsumi K"/>
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                <person name="Kageyama Y"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="GCB69258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="10923" checksum="2576AB402DBBB8CF" modified="2019-05-08" version="1">MVDGAPGQCVCNHLNPKKICSGKELLDFSKPTEFVPHKLKHRFQSSQTQETSRRKTYFNLSFLCSSPSLLRLHRPVRGITVIDGLGRCAAITGVEQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9W1</accession>
    <name>A0A401P9W1_SCYTO</name>
    <protein>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
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                <person name="Tatsumi K"/>
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                <person name="Kageyama Y"/>
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                <person name="Adachi N"/>
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                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000246">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401P9W1"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058839">
        <property type="entry name" value="WHD_HELB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF6">
        <property type="entry name" value="DNA HELICASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25894">
        <property type="entry name" value="WHD_HELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase B winged helix" evidence="5">
        <location>
            <begin position="233"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="4">
        <location>
            <begin position="739"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB69890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114975" checksum="EBCB21CB68501894" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PA23</accession>
    <name>A0A401PA23_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006067">
        <property type="protein sequence ID" value="GCB69952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PA23"/>
    <dbReference type="STRING" id="75743.A0A401PA23"/>
    <dbReference type="OMA" id="ENKQHIC"/>
    <dbReference type="OrthoDB" id="5597713at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF52">
        <property type="entry name" value="GRANZYME K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="9335" checksum="BAA60094CA23CBB9" modified="2019-05-08" version="1">MNLPSLHSNNIDKMSNPFCVELIIFTILFLTLQACVCTEIIGGRVIKPHSRPYMVSIQENKQHICGGALIARRWVLTAAHCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAT5</accession>
    <name>A0A401PAT5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003289">
        <property type="protein sequence ID" value="GCB70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAT5"/>
    <dbReference type="STRING" id="75743.A0A401PAT5"/>
    <dbReference type="OrthoDB" id="9378527at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF16">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="12336" checksum="7BEBC12C71BC5DFC" modified="2019-05-08" version="1">MADFDLIDALHESTPSVEPEVKRDFIASLEAEKYDDVVGESFTKENYVPLLDDDETKSPSLSEAKANAVVHLYGKTSPEQDGDGGQLAERSGASEQGPGDVPNGEHGVGKADDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB77</accession>
    <name>A0A401PB77_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004704">
        <property type="protein sequence ID" value="GCB70377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB77"/>
    <dbReference type="STRING" id="75743.A0A401PB77"/>
    <dbReference type="OrthoDB" id="206339at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060287">
        <property type="term" value="P:epithelial cilium movement involved in determination of left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055289">
        <property type="entry name" value="OFD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063:SF1">
        <property type="entry name" value="OFD1 CENTRIOLE AND CENTRIOLAR SATELLITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063">
        <property type="entry name" value="ORAL-FACIAL-DIGITAL SYNDROME 1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="241" mass="28812" checksum="D9287E8F123D8F96" modified="2019-05-08" version="1">MSQELQHFKDLKLAKVWIQEKEHSQKNIEEHRSKPDKMYQMQSETLITKEKNAIERPQKQQENLRDQRNKSLEQDLWRWELAVKSIEGTYEQKLKNELCRCQLELQEGYCKGTEKITVNEKVIEAEDIADYASLKREITELQAEINTLRKQLDEAENQKLCETLNQPTAAHLALQAELKKTEYPRKLAQGEYQNHKWIPEQQLQNEVEHYSKVRRQLLKYEDQTRRLNGQVNNLKLQLRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC01</accession>
    <name>A0A401PC01_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004750">
        <property type="protein sequence ID" value="GCB70648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC01"/>
    <dbReference type="OrthoDB" id="10030815at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="180" mass="20325" checksum="6B75EF04990E88DC" modified="2019-05-08" version="1">MAVATSTMEKRVVDFYLNKNRVIGGTIFPHKGIHKGFIIELRNCFSVLANADEEDQDTVEKKWSNITEAYTETAGKVIGFRHKKWLTRARWKKKEEDRSNHTMPVKDKHGGVITTEKEQVAKWVQCFEEALNQPEPDEPANSPASDDIGGMDTSPPIETEIPAALKAVKKTELTHCRQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC60</accession>
    <name>A0A401PC60_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0010838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004761">
        <property type="protein sequence ID" value="GCB70712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC60"/>
    <dbReference type="STRING" id="75743.A0A401PC60"/>
    <dbReference type="OMA" id="ETWKENM"/>
    <dbReference type="OrthoDB" id="6220511at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042421">
        <property type="entry name" value="C3orf33-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434:SF1">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="262" mass="29708" checksum="FB2DBA9A68947A7E" modified="2019-05-08" version="1">MLPGGAGFRLCYESLAAVMPEQGSNVLGGYLSQLGQFADEHIRAVQNLSTGLAVVGVVMFARSIRLFTKFTSAAEIPDRFIEKSVQLRGRVHHITRNGLEIEHIPITLPVISSLQRRWQSNGHLMVRLAGLQMTDEGRTWLREQIKPSQVVWFQPLRRENSFIDCIVRFNKGGFFLASLNEEILRNGLGRTVNIEGLNSNPKLYWRLQTKLLKAELNALKKDHITSTNDRFTVDWGPRIFTGGFIQQQMVQKFLGGNQDQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCJ6</accession>
    <name>A0A401PCJ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="12">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0005788</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety. The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle.</text>
    </comment>
    <comment type="function">
        <text evidence="12">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17018"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="12">Binds 2 lipoyl cofactors covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the pyruvate dehydrogenase complex (PDHc) that is a multi-enzyme complex composed of multiple copies of three enzymes, pyruvate dehydrogenase (subunits PDH1A and PDHB, E1 component), dihydrolipoamide acetyltransferase (DLAT, E2 component), and dihydrolipoamide dehydrogenase (DLD, E3 component) to which is added an additional protein the E3-binding protein (PDHX, E3BP). In terms of structural architecture, the E2 and E3BP components assemble into a 60meric central core with icosahedral symmetry. The central core is decorated with E1 and E3 proteins. Currently, two alternative models for the E2:E3BP stoichiometry are considered as being either 48:12 (E2(48)-E3BP(12)) or 40:20 (E2(40)-E3BP(20)). Interacts with PDK2 and PDK3. Interacts with SIRT4. Interacts with PDHB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="12"/>
    <dbReference type="EMBL" id="BFAA01001855">
        <property type="protein sequence ID" value="GCB70846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCJ6"/>
    <dbReference type="STRING" id="75743.A0A401PCJ6"/>
    <dbReference type="OMA" id="LQKVPQC"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000005">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5 12" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="235"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="15">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB70846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="654" mass="69957" checksum="C71B7D6751C80ECD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCZ1</accession>
    <name>A0A401PCZ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NEK6-subfamily protein kinase</fullName>
            <ecNumber evidence="14">2.7.11.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0005811</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.34" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01001870">
        <property type="protein sequence ID" value="GCB70994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCZ1"/>
    <dbReference type="STRING" id="75743.A0A401PCZ1"/>
    <dbReference type="OMA" id="RELVIMC"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08224">
        <property type="entry name" value="STKc_Nek6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000204">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000240">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF13">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="66"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB70994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="334" mass="38492" checksum="0607188B507F6C68" modified="2019-05-08" version="1">MKFQGSIATGLTKKASHRHATMEQQRNHPHALEVQSNHLYKSGTGYQQEAQRHTPTYDYHSSLADFQIVKKIGRGQFSEVYRATYLHNGKAVALKKVQVFEMMDAKARQDCINEIDLLKQLNHPNIIKYLDSFIENNELNIVLELADAGDLSQMIKYFKKQKRLIPERTIWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGAVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDVWSLGCLLYEMAALQSPFYGDKMNLFSLCKKIEQCDYPPLPTEHYSEKLRELVIMCINPEPDLRPDVSYMHQIAKQMHGWTQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD13</accession>
    <name>A0A401PD13_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003394">
        <property type="protein sequence ID" value="GCB70998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD13"/>
    <dbReference type="STRING" id="75743.A0A401PD13"/>
    <dbReference type="OMA" id="QENCTRQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="188" mass="22107" checksum="440415163CF64BBE" modified="2019-05-08" version="1">MARKDTGERAWKDSGERERKDTGERARKDTGERVRKDSGERVRKDSGERARKDSGERVRKDSGERAWNDSEERARKVCGERARKDTGERARKDCRERAQKDTGEKARKETEERTRKDTGARARKDSGERAWKDSGERVWKDCRERARKDCWEKEWKDSGSERARKGTGESARKDTGERAWKECRERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE05</accession>
    <name>A0A401PE05_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0001533</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cell membrane</location>
            <topology evidence="1 17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000348">
        <property type="protein sequence ID" value="GCB71339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE05"/>
    <dbReference type="STRING" id="75743.A0A401PE05"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF9">
        <property type="entry name" value="INTEGRIN BETA-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PSI" evidence="19">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="18">
        <location>
            <begin position="53"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB71339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="402" mass="44011" checksum="77AE96B2FC8A591F" modified="2019-05-08" version="1">MKQRVFVIATGSFPKPRHFPAKTFLSVVHILTIAVVAGKTGVRNKCTADKTNRCNECLRLGPECGWCFQKDFPDELLHRCDLITNLIQKGCNSDFIEFLEVKKIMEEESQSSQLSASKVSLQLQPGWRKDAKHLLLLITDQLSHLALDSKLGGIVLPNDGNCHLKDNMYTHSTIMEHPSVGLLVDKLLENNIHVIFAVQGSCINWYKDLLPLMPGAVAKQLNAEFSNLSELLEGAYKTLLSEVELQVDNLINGVYVNITAICPDGTEHPGHNKCKNVKASDIVSFNITVGMTDCYEGDKYIILKPVGYNETTVISAAYVLAMVNVKEGNANATPAGKVKAVTVHHPSCLAGQGRVKSAVEEGHVFVVDVIALNPEHLAICVRFALHVKIPVKTAGSVCSVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGD9</accession>
    <name>A0A401PGD9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL19m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L19, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0001864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000435">
        <property type="protein sequence ID" value="GCB72196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGD9"/>
    <dbReference type="STRING" id="75743.A0A401PGD9"/>
    <dbReference type="OMA" id="IHEIQVV"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000002">
        <property type="entry name" value="39S ribosomal protein L19, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB72196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="278" mass="32148" checksum="6FF73AB57E013FED" modified="2019-05-08" version="1">MAAVEAVVLGSRALSASKRVLFSPMRLLSSSTGDDKPSKFQPPSKPVIIDKTQSVATQRRFVSPEFIMRRGRTNPLKFSIERKDMIQRRKVLNIPEFYVGSILGVSMADTNANSKVNRFVGICTQRSGKGLGATFVLRNIIDGQGVEICYDMYSPRIQQIEVLKLEKRLDDNLMYLRDALPEYSTFDFNMKPLPYTTSSEVPINLLKVKMKPKPWSKRWERPQFKVQGIRFDLCLTEEQMEEAKKHDRPWLEHDMMREYDTSQIEKNMELYLQKGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGR1</accession>
    <name>A0A401PGR1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-aminobutyric acid receptor subunit alpha-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">GABA(A) receptor subunit alpha-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">scyTo_0006230</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="25">Postsynaptic cell membrane</location>
            <topology evidence="25">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002064">
        <property type="protein sequence ID" value="GCB72274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGR1"/>
    <dbReference type="STRING" id="75743.A0A401PGR1"/>
    <dbReference type="OMA" id="AXSITEV"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19052">
        <property type="entry name" value="LGIC_TM_GABAAR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000001">
        <property type="entry name" value="Gamma-aminobutyric acid A receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000002">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit alpha-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005432">
        <property type="entry name" value="GABBAa2_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047024">
        <property type="entry name" value="Gabra-1-6_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01615">
        <property type="entry name" value="GABAARALPHA2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0868">Chloride</keyword>
    <keyword evidence="15" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="22" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21 26" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 26" id="KW-0406">Ion transport</keyword>
    <keyword evidence="20" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 26" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="28">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="29">
        <location>
            <begin position="234"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="29">
        <location>
            <begin position="332"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="30">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00033009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="GCB72274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="433" mass="49205" checksum="9A7C5C73B202CFC3" modified="2019-05-08" version="1" fragment="single">RRGEPGSVEDEARNNITIFTRILDRLLDGYDNRLRPGLGERITEVKTDIYVTSFGPVSDTDMEYTIDVFFRQSWKDERLKFKGPMNILRLNNLMASKIWTPDTFFYNGKKSVAHNMTMPNKLLRIQDDGKLLYTMRLTVQAECPMHLEDFPMDAHACPLKFGSYAYTSAEVNYNWTNGPERSVEVAEDGSRLNQYDLLGQTVGEELVQSSTGEYKVMTTYFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKDKASVMKKNNAYAVAVANYAPNITKDSALPTIAKSATAEPKEAKPETKPQEAKKTFNSVSKIDRMSRIMFPVLFGTFNLVYWATYLNRELVVKGMSNDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGY6</accession>
    <name>A0A401PGY6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger and BTB domain-containing protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Zinc finger protein 238</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0001974</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000462">
        <property type="protein sequence ID" value="GCB72397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGY6"/>
    <dbReference type="STRING" id="75743.A0A401PGY6"/>
    <dbReference type="OMA" id="HCELINT"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18324">
        <property type="entry name" value="BTB_POZ_ZBTB18_RP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000114">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000220">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000021">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000892">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF18">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="16">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB72397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="524" mass="58390" checksum="63DCFDF3C4CD999F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHH3</accession>
    <name>A0A401PHH3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01002137">
        <property type="protein sequence ID" value="GCB72585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHH3"/>
    <dbReference type="STRING" id="75743.A0A401PHH3"/>
    <dbReference type="OMA" id="LMWISPF"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="31"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB72585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="208" mass="24004" checksum="10307BAF83536FDD" modified="2019-05-08" version="1">MLTDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCSIKPERAHHCSICKRCIRKMDHHCPWVNNCVGENNQKFFVLFTLYIALISVHALILCCFQFYFCIREQWSECSGFSPPVTVILIIFLCLEGVLFVTFTSVMFGTQLHSICNDETEIERLKNEKPTWERKLRWEGMKNVFGGQPSFLWINPFSGVRIRRLIPRRMKGGAEFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIT7</accession>
    <name>A0A401PIT7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000575">
        <property type="protein sequence ID" value="GCB73046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIT7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="78" mass="8895" checksum="882A90EBC2A639DD" modified="2019-05-08" version="1">MATQPFNVILRQCHRGTTTEYGTLHNVVDFEEGEALEQYRASEKEEESEVKEREEEEEYGENKHALAAQGGGQGQHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIX2</accession>
    <name>A0A401PIX2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002257">
        <property type="protein sequence ID" value="GCB73064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIX2"/>
    <dbReference type="OMA" id="KGLWGHI"/>
    <dbReference type="OrthoDB" id="199838at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="326" mass="37703" checksum="BF91AD04CCAECAFE" modified="2019-05-08" version="1">MQWGSCVLASASQNYAEAKVDQNEKLPVNSSPKQLLIDKVLARCRFGQLVKEKEQHAQNRKLEEDKERLMQELHKLQLQKKHLGPEFIVPSNAQDKHSALQARIIQIRNNLPTMEDRIQELRKNIFGGDNEKRQTSYNEDSIFEGAEPYQIRNINMVRSILSDVVEKLMDDYTRKAPDGMDPFTAEYPFAFLDFNSSYLAWKTAQEADAVMKEVMMDRVTNLVMEQFVLEVTLELSSEVVEEFFSVNQMSRSLAFDVIFNAVQEVGKQRQTQSGDEKFTASSDLLITLLLEQQKDRELRRKGLWGHIQDNHATKMPGNDHLQHERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJM8</accession>
    <name>A0A401PJM8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional activator Myb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0002476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000622">
        <property type="protein sequence ID" value="GCB73322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJM8"/>
    <dbReference type="STRING" id="75743.A0A401PJM8"/>
    <dbReference type="OMA" id="WEPATCG"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000042">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015395">
        <property type="entry name" value="C-myb_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012642">
        <property type="entry name" value="Tscrpt_reg_Wos2-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09316">
        <property type="entry name" value="Cmyb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07988">
        <property type="entry name" value="LMSTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB73322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="558" mass="63313" checksum="D95340130647B6AE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK55</accession>
    <name>A0A401PK55_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisome proliferator-activated receptor alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nuclear receptor subfamily 1 group C member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0002575</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000654">
        <property type="protein sequence ID" value="GCB73496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK55"/>
    <dbReference type="STRING" id="75743.A0A401PK55"/>
    <dbReference type="OMA" id="YDQCERN"/>
    <dbReference type="OrthoDB" id="7634782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010887">
        <property type="term" value="P:negative regulation of cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045923">
        <property type="term" value="P:positive regulation of fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06965">
        <property type="entry name" value="NR_DBD_Ppar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06932">
        <property type="entry name" value="NR_LBD_PPAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000013">
        <property type="entry name" value="Peroxisome proliferator-activated receptor delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000010">
        <property type="entry name" value="Peroxisome proliferator-activated receptor gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003074">
        <property type="entry name" value="1Cnucl_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003076">
        <property type="entry name" value="PPAR-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF197">
        <property type="entry name" value="PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01288">
        <property type="entry name" value="PROXISOMEPAR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01289">
        <property type="entry name" value="PROXISOMPAAR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="17">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="18">
        <location>
            <begin position="236"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB73496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="465" mass="52369" checksum="CE32D8F9C4E6C21A" modified="2019-05-08" version="1">MVDTQIHSNPLSPLENDSGTPLAGEFVQEMENVQDASQSVGDNSSETFSIDENLTSGNGPGSNETVPDTLTPASSPSSAIFPVTPLAQDEASTSSLSIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLDYDQCERNCKIQKKNRNKCQSCRFQKCLSVGMSHNAIRFGRMPQSEKEKLKAEILTLEQDVQNSQMADLKTLAKHMFEAYLKNFNMNKTKARAILTGKANIPPFVIHDMETLRLAEENLVSKQAVNGIQNKEAEVRIFQRCQCTSVETVRELTEFAKCIPEFINLDLNDQVTLLKYGVYEAMFAMLASIMNKDGLLVAYGNGFMTREFLKSLRKPFNEIMEPKFEFAMKFNALELDDNDLALFVAAIILSGDRPGLVNVSQIEQMQETIVQALRLHLHSNHPDAIYLFPKLLQKMADLRQLVTEHAQLVQKIKKTEADTFLHPLLQEIYRDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNG1</accession>
    <name>A0A401PNG1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001055">
        <property type="protein sequence ID" value="GCB74664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNG1"/>
    <dbReference type="STRING" id="75743.A0A401PNG1"/>
    <dbReference type="OrthoDB" id="9925752at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019530420" description="CWH43-like N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="66" mass="7394" checksum="3686CF6DAF9A536C" modified="2019-05-08" version="1">MTAWLILPVCLSVSTITALWVVYAVAVRNHHVCPVDNWIYNESCGAVSVYGERKECCTLNDIPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNL8</accession>
    <name>A0A401PNL8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0003817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001070">
        <property type="protein sequence ID" value="GCB74726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNL8"/>
    <dbReference type="STRING" id="75743.A0A401PNL8"/>
    <dbReference type="OMA" id="ANVACER"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18592">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000012">
        <property type="entry name" value="ATP binding cassette subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF196">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="201"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB74726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="639" mass="72533" checksum="54A7C4FFD24E8DD1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP27</accession>
    <name>A0A401PP27_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017427">
        <property type="protein sequence ID" value="GCB74869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP27"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="120" mass="12207" checksum="5A19ACB2E8C2DD4F" modified="2019-05-08" version="1">MGDVPSVNTAGGGISSLRSPGEESSQGSTDGDVIGQSPRAKVCDPHPEVISEPSEAIGGLASDSQALTGQSSGESNMIEGKKEAARSEADTATGRRRRHTGLLEASNSKQVKLTASPLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQF0</accession>
    <name>A0A401PQF0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017617">
        <property type="protein sequence ID" value="GCB75349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQF0"/>
    <dbReference type="STRING" id="75743.A0A401PQF0"/>
    <dbReference type="OMA" id="HRENTEW"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000013">
        <property type="entry name" value="IQ motif containing GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF10">
        <property type="entry name" value="RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="375" mass="42650" checksum="B216F09E46900AFD" modified="2019-05-08" version="1" fragment="single">MDERRRQNIAYEYLCHLEEAKRWIEACLGEELPPTTDLEESLRNGVTLAKLGHRFAPDVVPQRKIYDGELLRYKATGLNFRHTDNINHWLKAMDKIALPSIFYPETTDIYDKKNSPRVVYCLHAFSIYLFKLGLAPQIQDLYGKVNFTVHAAVIAINEAIERGMAEQTMLALHNPNAMLANLLDGLALVYQEVLYQAKSEKTANARNRVGVYKPEQDVYEELLTRAEIQGNVNKVNVHAAMEYVDEALEKGDVQALYSALQSEALGLREVHRENTEWYMEQLLIDREQKSLELGMMEPLEKEELQAAVEAANENANVHLCMMQAVSRINEAVRSGVPSQTVKELMNSSAKLPDVYPFAAGLYQRELAALQQQKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSJ6</accession>
    <name>A0A401PSJ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011306">
        <property type="protein sequence ID" value="GCB76078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSJ6"/>
    <dbReference type="STRING" id="75743.A0A401PSJ6"/>
    <dbReference type="OMA" id="NAISACF"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="421"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="704" mass="80722" checksum="F752827819CD05B0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSV3</accession>
    <name>A0A401PSV3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0015445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008763">
        <property type="protein sequence ID" value="GCB76187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSV3"/>
    <dbReference type="STRING" id="75743.A0A401PSV3"/>
    <dbReference type="OMA" id="HAQEWSS"/>
    <dbReference type="OrthoDB" id="513400at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="9"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB76187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="485" mass="53247" checksum="CC6606D74ADE8E2C" modified="2019-05-08" version="1">MLLEAAIAAKRKTYFGLAQISNGIFGKLVVAISMIGLMLGTCIAFFAVLHDLGANLYLALTGTPSTPWQCALALFTITSAVILPLSLEKNMSDSAWQSVFSLIFYLLLIIVLLAYCLNSVLSGDMVMENVRLWQWSGIATSLPIFATSFCCHPLVLPIFFNLRGQSVVQMNGVFKRATIITFTLYTVVGLCGYLPLTEAVPGDILAALPPSFVTYGIRAIFYISLALSFPMIILPCRQAISTLFIEQQKDDGTFSVSGDMPFHQHVTATVFIVYCTMSLGILVPDVETVLGIMGTTMGSFICFICPSVIHAKLRKHTFTGSLVLGVGILLLLIRVSSIIDLNGKNFHLQVALKSRAADESGNAKPEYRNKDPVLPGLMRNGGEKQFKRQGRGLITRPGEANAKSVVTRETDGSEEAVKHREAGTSMEERLKELKERERRKALKILSEIRQKAKRSNPPGRTHAQEWSSPDTVPADRLKRNQQIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSZ1</accession>
    <name>A0A401PSZ1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015236">
        <property type="protein sequence ID" value="GCB76254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSZ1"/>
    <dbReference type="STRING" id="75743.A0A401PSZ1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="187" mass="20788" checksum="768BDD916D6F71DF" modified="2019-05-08" version="1">MIHIRDFRIRHVRTRDDPYPRRSYGRHPAHVLGVFDGDHVLGMFDGDQVLGVFDRDHVLGVFEGDHVLGMFDGDHVLGVFDGDHGLGVFHGYHVLGVFDGDHVLGVFDGDHVLGVFDVDHVLRVFDGNPVLAVYNGGHVLRVFDGDRVLGVFDGDHVLGVFDGAMFCECLMGTMAWECLMGTVFWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTZ2</accession>
    <name>A0A401PTZ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TP53 regulated inhibitor of apoptosis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:36435"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010098">
        <property type="protein sequence ID" value="GCB76575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTZ2"/>
    <dbReference type="STRING" id="75743.A0A401PTZ2"/>
    <dbReference type="OMA" id="KHKYDQC"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9049" checksum="3277F8D13B6C55BD" modified="2019-05-08" version="1">MNSVGTECLELKRGYDLCFNRWFAEKFLKGERSADPCSELFKQYQECVKKAIKEKEIPIEGLEFMGSKREKPHGNAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUE1</accession>
    <name>A0A401PUE1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012747">
        <property type="protein sequence ID" value="GCB76759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUE1"/>
    <dbReference type="STRING" id="75743.A0A401PUE1"/>
    <dbReference type="OMA" id="IDVITWK"/>
    <dbReference type="OrthoDB" id="409644at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8627" checksum="C48F3E9167AA03A2" modified="2019-05-08" version="1" fragment="single">KYAALDVNIIPSLLILVDDPGPKVRLNAIKVITTVSESPEGRRLLLDHVAFLQEKLQDPSEAVRKAVKIAIDIITWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUF4</accession>
    <name>A0A401PUF4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoplasmin core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0018373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoplasmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012742">
        <property type="protein sequence ID" value="GCB76732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUF4"/>
    <dbReference type="STRING" id="75743.A0A401PUF4"/>
    <dbReference type="OMA" id="GQECYES"/>
    <dbReference type="OrthoDB" id="6075101at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004301">
        <property type="entry name" value="Nucleoplasmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024057">
        <property type="entry name" value="Nucleoplasmin_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747:SF18">
        <property type="entry name" value="GEO09167P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747">
        <property type="entry name" value="NUCLEOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03066">
        <property type="entry name" value="Nucleoplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin core" evidence="5">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB76732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="174" mass="19237" checksum="5C9C707C0BB2AA75" modified="2019-05-08" version="1">MTSNKNSKPDMTVAVLWSCELNAGQTTQKFQISDDEIWEHQLALKTICLGVGAKDELNIVEIVPENEGAAVPIAALQLSILPMTTISGIELTPPVTFRLKSGSGPVYVTGQNLVLEDYSWDDEEEDMVEEEEEEEEEVETPPKPAKRSATTKKAGLSKKKKMEAEKTEEKRSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWB5</accession>
    <name>A0A401PWB5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014177">
        <property type="protein sequence ID" value="GCB77398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWB5"/>
    <dbReference type="STRING" id="75743.A0A401PWB5"/>
    <dbReference type="OMA" id="MCVEIDS"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB77398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="204" mass="21594" checksum="71131436FD611FBB" modified="2019-05-08" version="1" fragment="single">ARSQQAITESFDVIAQTLAQSQQAITESINSIAQVMAQSQQAIAESIDGIAQVMAQSQQAITESIGSNALMLARYQQAIAESIDSIAQMMARYQQAIAESIGGIAQVMARYQQAITESIGSIAQMLAQSLQAITESIGGIAQMVAQSQQAIAESIDSIAQVMAQSQQAIADSIDSIAQMVAQSQQAITASAGVRNFRAARRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWB7</accession>
    <name>A0A401PWB7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0019281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. PAR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014180">
        <property type="protein sequence ID" value="GCB77415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWB7"/>
    <dbReference type="STRING" id="75743.A0A401PWB7"/>
    <dbReference type="OMA" id="LMENPRE"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000007">
        <property type="entry name" value="hepatic leukemia factor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF24">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB77415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="288" mass="32794" checksum="E88AADEDAF9F5E35" modified="2019-05-08" version="1">MTDLGLGFQRLCTDIAVQLLFLWLLVAVGSIYPRPFKTDKELAASVFFRKDEDKEKNVDEAASSNTAASASLMPTIWDKTIPYDGETFHLEYMDLDEFLLENGIPDGSSQFALQDSLLPVVELEEKALSPTLSSLSRSMTYSEVDSDEGDERKPVRTTPNSDLDVIDVLVNFDPDPTDLALSSVPGGELFNPRKHKFSDEELKPQPMIKKARKIYVPTEQKDDRYWARRKKNNVAAKRSRDARRLKENQITVRAAFLEKENSALRLEVLELRKEVARYKTIISKYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY12</accession>
    <name>A0A401PY12_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016964">
        <property type="protein sequence ID" value="GCB78034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY12"/>
    <dbReference type="STRING" id="75743.A0A401PY12"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10807" checksum="10855606BD7FA796" modified="2019-05-08" version="1" fragment="single">MNKTSKGHIAFVIMILEILIFFLSLYFGLKSKETPPYSFERAVVAADAERCSEIGRDILKQNGSAVDATIATMLCNGLMNVHSMGIGGGFIMIIYNAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZG1</accession>
    <name>A0A401PZG1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amiloride-sensitive sodium channel subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0020105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015748">
        <property type="protein sequence ID" value="GCB78423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZG1"/>
    <dbReference type="STRING" id="75743.A0A401PZG1"/>
    <dbReference type="OMA" id="NATHENM"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF19">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB78423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38341" checksum="61652869174EDCC6" modified="2019-05-08" version="1" fragment="single">TLHLDENEYNPYLFTSMGAKIVIHDQNEQPFVEDMGIEIQTATETAMGLDKTVLKRLSSPYSDCTVDGFDVPVINLYNKTYSLQMCLHSCFQMEMVRSCGCAHYAKPLPPEAEYCDYTKYPGWISCYYRLRNQFIQEQLVCQKTCRPACHSKEWTMTISDAEWPSSPSEEWILHLLSWEKGLRGNRTLRKNELANLGIFYKDLNQRNISETAANDIVTLLSNFGGQLGLWMSCSVVCIIEIVEVFIFDMFLIIGRKCVQTVRKWWQKEQEELPPTISNSAHGAPFCISDEDPPTFNSALQLPRPPCPDTLPPTYETLRIRSSFIPDISTVESCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZI7</accession>
    <name>A0A401PZI7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0019430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014442">
        <property type="protein sequence ID" value="GCB78564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZI7"/>
    <dbReference type="STRING" id="75743.A0A401PZI7"/>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="110" mass="12318" checksum="E9404380E514BB6B" modified="2019-05-08" version="1">MGYILSVAVAPHQGGECPLQHFNSLLCLSWLQRYADGVLLFHNDDVLRRMQASCGRKIEQVPALEPQISFSDMNTHIASCLAALMHPVRSLRTPRYDILGKESAKEFLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1G4</accession>
    <name>A0A401Q1G4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Polycystin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">scyTo_0017857</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011952">
        <property type="protein sequence ID" value="GCB79225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1G4"/>
    <dbReference type="STRING" id="75743.A0A401Q1G4"/>
    <dbReference type="OMA" id="REWYIRT"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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            <position position="482"/>
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        </source>
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    <sequence length="684" mass="79290" checksum="3AE9F054676A238D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q203</accession>
    <name>A0A401Q203_SCYTO</name>
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        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="176" mass="20364" checksum="1AB2B6465DB0FEAD" modified="2019-05-08" version="1">MEKEEDAIQAIANLDEKEFNGNKLRVQLSRSTYGKSGGQRDVCQRCGRQGHQARDCHSSRHSQYNPQQLQSQYHPSYYSYYDYDYGHGSYYDYYEDYQAAGAAPSYAPLDYVRERSPSRLSTPAPAAAANSCTLYERTRLSPLSLPKYQNEKFVDDSISRYDQFDYDNTTDTRYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q219</accession>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="GCB79457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.740.10:FF:000001">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.740.10">
        <property type="entry name" value="Coagulation Factor IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017857">
        <property type="entry name" value="Coagulation_fac-like_Gla_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035972">
        <property type="entry name" value="GLA-like_dom_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000294">
        <property type="entry name" value="GLA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050442">
        <property type="entry name" value="Peptidase_S1_coag_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278">
        <property type="entry name" value="COAGULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278:SF26">
        <property type="entry name" value="COAGULATION FACTOR VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00594">
        <property type="entry name" value="Gla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00001">
        <property type="entry name" value="GLABLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00069">
        <property type="entry name" value="GLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57630">
        <property type="entry name" value="GLA-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00011">
        <property type="entry name" value="GLA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50998">
        <property type="entry name" value="GLA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Gla" evidence="5">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="14440" checksum="9F863C1C84B3191A" modified="2019-05-08" version="1" fragment="single">CTVPLLCSLNQPCVFSKNNLSTILTTAGEILKMQTKALEYRQKLLRHNQHLLEQMKPEAVRFLSRFRRANHFAEEFKAGNLERECLEETCSKEEVREIFEDDVQTNLFWDFYTGTCSLTYLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2V1</accession>
    <name>A0A401Q2V1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0016993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010706">
        <property type="protein sequence ID" value="GCB79688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2V1"/>
    <dbReference type="STRING" id="75743.A0A401Q2V1"/>
    <dbReference type="OrthoDB" id="8610216at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF9">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB79688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="486" mass="55367" checksum="14ADD9AA9EF10049" modified="2019-05-08" version="1">MNHQPDHRKAKISKSCPPSLRIEDTEQLLKEFYRESLSSIETDHWLDLMDSESNSAKRNSNPYLDYFNDVDTAANFKLHGAEYDLIQKIEKQKIQEDSRNAINCEDERNKNWEDGNNQHEELPGIESQPQAYDSYNEGKDWQCVYTLGCGKFGEVTLVYDKNKKLTCAAKKVPKKYYRREELEIWRSLKATNIVQLLGAVRHGDFVTFFMELVNGDNILLSDTEQRLLLCDFTFAKKLPLGQFTPKGEAPVGTPTHMAPEVALSAGHDWRADVWSATCTFLHMINGRHPWVKKFADIYVLLKVIAEESPPYFEIPPSCHILVDSLIKRGLMVNQYERPFAATLRDEAADVMTQISGLQFIFGEQYAEVSSPLCNENMSEYPSQTKLELSSILKDLKDPSPGSDLKPESENKVNEVQLVVGNTSENQQSLQRKIEDTTEKEKKNANSSKPCGANIENQISTSKRNQQFFHGKVKRLQSCPVTAITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q304</accession>
    <name>A0A401Q304_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013435">
        <property type="protein sequence ID" value="GCB79746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q304"/>
    <dbReference type="STRING" id="75743.A0A401Q304"/>
    <dbReference type="OrthoDB" id="5950832at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="165" mass="18196" checksum="B8BF572EE73DC4A4" modified="2019-05-08" version="1">MESSVFEMMEDSVFEMMEGSVLRMMEGSVLSMMEGSVSDMMEGSVLRMMEGSVLRMMEDSVLDMMEGSVLDMMEGSVLNMMEGSVLDMEGSVLRMMKGSVLDMEGSVLDIMEGSVLRMMEGSVLDMMEGSVLRMIEGSVLEMLESSMLGVMEGLVLRMMEGSVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3E4</accession>
    <name>A0A401Q3E4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014792">
        <property type="protein sequence ID" value="GCB79896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3E4"/>
    <dbReference type="STRING" id="75743.A0A401Q3E4"/>
    <dbReference type="OMA" id="WARMASF"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000029">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33593" checksum="32414366B98EAC8C" modified="2019-05-08" version="1" fragment="single">DVTITNDGATILKLLEVEHPAAKVLCELAELQDKEVGDGTTSVVIIAAELLKGADELVKQKIHPTSIIGGYRLACKEAVRYIQENLTINMDELGRECLVNAAKTSMSSKIIGVDADFFANMVVDAAHAVKFTDAKGQARYPIKAINLLKAHGRSQRESLLVNGYALNCTVGSQAMTKRIINAKIACLDFSLQKTKMKLGIQVVISDPEKLDQIRQRESDITKERIHKILATGANVILTTGGIDDMCLKYFVDAGAMAVRRCLKKDLKRIAKASGGKYKNQTCWELQYMKRETELTFQYVDLKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3G6</accession>
    <name>A0A401Q3G6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">YAP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013497">
        <property type="protein sequence ID" value="GCB79932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3G6"/>
    <dbReference type="STRING" id="75743.A0A401Q3G6"/>
    <dbReference type="OMA" id="CWANINY"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000001">
        <property type="entry name" value="Transcriptional enhancer factor TEF-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YAP binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB79932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="22478" checksum="1984A5386EFB0C81" modified="2019-05-08" version="1" fragment="single">YNKHLFVHIGQTNHSYSDPLLESVDIRQIYDKFPEKKGGLKELYGKGPHNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTITCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSTSEHGAQHHTYRLMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3Z7</accession>
    <name>A0A401Q3Z7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0019656</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014838">
        <property type="protein sequence ID" value="GCB80074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3Z7"/>
    <dbReference type="STRING" id="75743.A0A401Q3Z7"/>
    <dbReference type="OMA" id="IPCERSY"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000119">
        <property type="entry name" value="Zinc finger and BTB domain containing 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000422">
        <property type="entry name" value="Zinc finger and BTB domain containing 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000364">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF32">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB80074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="211" mass="23791" checksum="324DC4B191DF3C97" modified="2019-05-08" version="1" fragment="single">DGWGLVCVAECGVHYSQFSPSGSVVCTVPERHRARSESPGKNEERKQPNSQTDEAPLFGVSGYEEYLRDQEVAERWYRYNPRLTCLYCGKSFNQKGSLDRHMRLHMGITPFVCRICGKKYTRKDQLEYHIRKHTGNKPFHCHVCGKSFPFQAILNQHFKKNHPGCTLLDGLHSISPETTTKGQNGEESPPQDEAKAIGELIHASVSTTGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4M3</accession>
    <name>A0A401Q4M3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009603">
        <property type="protein sequence ID" value="GCB80323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4M3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="110" mass="12865" checksum="71FD14DAC11CAC28" modified="2019-05-08" version="1">MGSTWLEKIRLNWGKVNDMTDFKSGLTKILKKHTIVFNGDLRSMKYISVKLKIKEESQTKYLKAREAVKAITNIQYLEYNDENPPVWFGYDNKGNELVTSKEEEEKTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q539</accession>
    <name>A0A401Q539_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress-induced-phosphoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0018131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012342">
        <property type="protein sequence ID" value="GCB80496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q539"/>
    <dbReference type="STRING" id="75743.A0A401Q539"/>
    <dbReference type="OMA" id="MYSAREN"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="9">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="9">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB80496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="569" mass="64809" checksum="8DCFF5D4C7ACC497" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6N9</accession>
    <name>A0A401Q6N9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018678">
        <property type="protein sequence ID" value="GCB81064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6N9"/>
    <dbReference type="STRING" id="75743.A0A401Q6N9"/>
    <dbReference type="OMA" id="CGSTNQY"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="216" mass="24735" checksum="A4563463DB916BA6" modified="2019-05-08" version="1">MEERKTDEGKIEEEKTEEGKTEEGKDEEGKTEEGKTEEGKFEEGKTEEGKKEERKIEEGKVEEGKTEEGRFEEGKTEEGMVEERKTEEGKIEEGKTEEGKIEEGKTEEGKTGEGKVEEGKTEEGKNEEGKTGEGKVEEGMVEEGKTEERKTEEGKTEEGKTEEGKIEEAKTVMGRLRKGRLRKGRLRKGRLRKGRLRKGKLWKGRLRKGRLRKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q774</accession>
    <name>A0A401Q774_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0022474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022670">
        <property type="protein sequence ID" value="GCB81222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q774"/>
    <dbReference type="STRING" id="75743.A0A401Q774"/>
    <dbReference type="OMA" id="HFPKLAW"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF29">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGAT4 conserved region" evidence="4">
        <location>
            <begin position="12"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="5">
        <location>
            <begin position="258"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB81222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="45317" checksum="2D1846647197849D" modified="2019-05-08" version="1" fragment="single">SETCNFVLAPQEYLTIGISTVRRMRGNYLMDTIQSIFEKSSFRELEQMVVVIYLADFDVSWNLKTAADIKARFASHIDAGRLLIIQCPRHIYPTLEGLKRNYNDPMERVQFRSKQNVDYAFLVNFCSGLSDYYLMLEDDVLCAQNFLSSMQTFIDSAMGSSWTTLTFSKLGYIGKLYHSVDLPKLARFLLMFYDDMPCDWLLAHFHKVKTQPSEIRFRPSLFQHMGTYSSFIGSRNSLKDDEFEENVGGLPDNPPALLFTDIPVYNTHLPVMVYNFGAGQFWGKSPKEGNYFLIVFKHPVKVIKIYIWTGSPEHKRDILHSGVVQVGRDVVSENNNQNCKSYRELGAFNAGKFEMENVTTQNSEPIDCVRVVVSKDQVEWLIISKVNIWIEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7G9</accession>
    <name>A0A401Q7G9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0023280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01027952">
        <property type="protein sequence ID" value="GCB81335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7G9"/>
    <dbReference type="STRING" id="75743.A0A401Q7G9"/>
    <dbReference type="OMA" id="WPKAGEH"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018526">
        <property type="entry name" value="Glyco_hydro_29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF45">
        <property type="entry name" value="PLASMA ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00385">
        <property type="entry name" value="ALPHA_L_FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB81335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="22614" checksum="FFEAC5F8D832ED7D" modified="2019-05-08" version="1" fragment="single">FTLWGSKYSWNWNALDSGPHRDLVGELADAVRNRTQLRFGLYHSLFEWFNPAFLQDAANVFKTNKFPTTKSLPELYEIVNKYRPEILWSDGDGNAPDTYWNSTGFLDWLYNHSPVRNTVVTNDRWGYGTICKHGGFYTCADRYNPGHLLAHKWENCMTLDRKSWGYRREAKLSDYLPIEQLVKVKPTPLSVCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7H6</accession>
    <name>A0A401Q7H6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LAMB1/2/3/4 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018830">
        <property type="protein sequence ID" value="GCB81322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7H6"/>
    <dbReference type="STRING" id="75743.A0A401Q7H6"/>
    <dbReference type="OMA" id="MTWRESC"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056558">
        <property type="entry name" value="LAMB1-4_helical"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23219">
        <property type="entry name" value="LAMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAMB1/2/3/4 helical" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="229" mass="26284" checksum="35A5C775ABD7E9F1" modified="2019-05-08" version="1" fragment="single">IENIANYVLSIKIPITPEEVKNKSKQIQDILSEIKDLDKALEKLNRHSEEAKILLKRAIKAENATQRIPSPKQLKKDLDDIKEVQKNVKDTVQKITDNLNDVQTKISQAGRKIESCFDKLMDLMNSVTKLQNEVEELENKISNNKKVSGMVMKKASEAKTQAEEAEQENTNNQQFLMRNPRTTDLEKKIQDGNKKIMEKTDYLSSLEQNVTAIKTEIEEKVSYYTDCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7V6</accession>
    <name>A0A401Q7V6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAZ1 C-terminal region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022817">
        <property type="protein sequence ID" value="GCB81446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7V6"/>
    <dbReference type="STRING" id="75743.A0A401Q7V6"/>
    <dbReference type="OMA" id="ATNPNKM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056615">
        <property type="entry name" value="FAZ1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23404">
        <property type="entry name" value="FAZ1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="2">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="20593" checksum="9341F66FB735DAF4" modified="2019-05-08" version="1">MGANPNKVATNPNKMATNPNKLANPNKMATDPKKVATNPNKMATNPNKLANTNKMATNPNKMAANPNKMAANPNKTASNPNKMAAKPNRTGANPNKMASNPNKLANPNKMATNPNKMGANPNKMATNPNKMGANPNKMVTNPNKLANPNKMATKPNKMGANPNKMAINPNKMATNGHLPKQDGCQTKHDGCQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q812</accession>
    <name>A0A401Q812_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">P-type phospholipid transporter</fullName>
            <ecNumber evidence="5">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0021412</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01018941">
        <property type="protein sequence ID" value="GCB81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q812"/>
    <dbReference type="STRING" id="75743.A0A401Q812"/>
    <dbReference type="OMA" id="ACCELDE"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140327">
        <property type="term" value="F:flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000012">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF52">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE FETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="209" mass="24053" checksum="E8AA099DB9F5D962" modified="2019-05-08" version="1" fragment="single">LLVYQAQSPDEGALVTAARNFGFVFRSRTPETITIVEMGETKIYELLSILDFDNVRKRMSVIVRHPDKKLYLYCKGADTIVFERLNSSSQQLRDITTSHLDEFAGDGLRTLALAYKELDEESFDNWQKRYQEASIALENRDEQLSELYEEIEKDLKLLGATAVEDKLQDGVPQTIQTLSKANIKIWVLTGDKQDLRVMFIIRILFDILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q982</accession>
    <name>A0A401Q982_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0021915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01020480">
        <property type="protein sequence ID" value="GCB81935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q982"/>
    <dbReference type="OMA" id="HYPLGCG"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB81935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="719" mass="75199" checksum="DC81E97507622A00" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q992</accession>
    <name>A0A401Q992_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0022257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021818">
        <property type="protein sequence ID" value="GCB81945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q992"/>
    <dbReference type="STRING" id="75743.A0A401Q992"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB81945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="50" mass="5856" checksum="243D243841397AB5" modified="2019-05-08" version="1" fragment="single">LKKQYPQYPLKIPAKRIFGDNFDPAFIKQRRAGLNEFIQKLVSHPSLSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9M5</accession>
    <name>A0A401Q9M5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0023327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01028453">
        <property type="protein sequence ID" value="GCB82079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9M5"/>
    <dbReference type="STRING" id="75743.A0A401Q9M5"/>
    <dbReference type="OMA" id="QMQHESS"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB82079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="96" mass="11070" checksum="0A5A0AF702950F59" modified="2019-05-08" version="1" fragment="single">DMHGVLVKLGEFLGKPLSEDVIRTIANHSKFDNMKQNNMSNYSFVPEELMDQKKSNFLRKGIAGDWKSHLTAAQTEHFNSIYAQKMEGLNFPFYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC28</accession>
    <name>A0A401QC28_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0023701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01032694">
        <property type="protein sequence ID" value="GCB82940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC28"/>
    <dbReference type="STRING" id="75743.A0A401QC28"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000658">
        <property type="entry name" value="Serine/threonine-protein kinase 11-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB82940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15601" checksum="B4348B8492EB929C" modified="2019-05-08" version="1" fragment="single">MPQAAQQLPLVKTKAPLSLTPPALSNSPHPQPLSELEYVNLSYNLLEKVPVFSSCSRVQLTTLLLRNNELENINGVEHLSHLKHLDLAYNMISEHSQLAPLSQLHSLKELFLEGNPVCYQKAHRPSTIHHLSPKAAFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCM8</accession>
    <name>A0A401QCM8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01033068">
        <property type="protein sequence ID" value="GCB83155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCM8"/>
    <dbReference type="STRING" id="75743.A0A401QCM8"/>
    <dbReference type="OMA" id="LWINGSG"/>
    <dbReference type="OrthoDB" id="8881103at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="279" mass="30709" checksum="783EF1CF57C65570" modified="2019-05-08" version="1" fragment="single">FLLWINGSGTVLHINGTVHNAGTPLCPPGPNSKPTENPTSLHIQPDIPSLTSEFQKFSPFGLDEVASKEKRDGDLTTEVDYLAQIPPLGGSARSSAASILTNSTIEYNAYYPPSNYYTSLTKEQSLESQESSTLSSPSDSLNQVPNTTSCSPVVGSSSLFQFPIGKILDEETEATTQNQEHNLFRPEQSTPGFYDSPHYPESQGSIGQTDMVSPVPSPLQISNRSPLIEKERSPDREQVNRIVMSVNDKWHYCHNSDVLVGSRAMRDRHLRLLGYTILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF09</accession>
    <name>A0A401QF09_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01052607">
        <property type="protein sequence ID" value="GCB83944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF09"/>
    <dbReference type="OMA" id="QWREASG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="251" mass="31308" checksum="6955BE1F70BE8564" modified="2019-05-08" version="1">MERDGWREMDGERRMERDGWRETVGERRMWRDGWREMDGEKDGETDGERWEERDGWRERRMERDGWRKMNGQRWMKRDGWGETDGERRMESRMGRRMERDGWREMDGERRMERDGWRETDGVRRMERDGWRETYGERRMERDGWREGWGDGWREMEGGRWMERGTDGERWMERDEWTEMDEERRMGRDGWRETDGERWMERDGWGDGWGEMDGEMDGEGWRETDGVTDGERWMERDGSREMDGERRMERDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG21</accession>
    <name>A0A401QG21_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01065772">
        <property type="protein sequence ID" value="GCB84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG21"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="71" mass="8237" checksum="45001C2AE110E7AE" modified="2019-05-08" version="1">MTARWEQDEHTTQLQQGENGENVRHNYSKVGTGRTYVTITAKWERGERTSQLQQSGKGENVRHNYSKVRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGG4</accession>
    <name>A0A401QGG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01070507">
        <property type="protein sequence ID" value="GCB84518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGG4"/>
    <dbReference type="STRING" id="75743.A0A401QGG4"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="44" mass="5043" checksum="49E2684FE2E6B468" modified="2019-05-08" version="1" fragment="single">VVEQGMFVKHCKVEVYLTELKLCENGNMNTVITRRFSKADIIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGY6</accession>
    <name>A0A401QGY6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01086246">
        <property type="protein sequence ID" value="GCB84603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGY6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7661" checksum="AF452185159C8800" modified="2019-05-08" version="1" fragment="single">MENDLVVKDDLVVEDDLVMEDFLVMKYDLVMEDDVVLEDDLVMENDLVVKGDLVVEDDLVVEDDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHK7</accession>
    <name>A0A401QHK7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01094520">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CPLANE1"/>
    </dbReference>
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        <property type="entry name" value="CILIOGENESIS AND PLANAR POLARITY EFFECTOR 1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="12258" checksum="923F385924B7845A" modified="2019-05-08" version="1" fragment="single">PDGEEMMSVLLQDLYRQKVKMLKRIVQSIGPTEQHVWERAEESLRDQEDQPYDRFSLGTSLSRSSLTDTRRSQNQGDGDTSDNISGECQDLSEWQDSIQQLTGTGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKC1</accession>
    <name>A0A401QKC1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
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        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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            <taxon>Scyliorhinus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
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            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01211510">
        <property type="protein sequence ID" value="GCB85867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QKC1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="62" mass="6522" checksum="073AA3740E1EDB4E" modified="2019-05-08" version="1" fragment="single">IHMYAVGVGDADITELRSIVTDGDSKNIVYAESFDSLTQFEGALADVICIAASKPDVSDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKL4</accession>
    <name>A0A401QKL4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01210788">
        <property type="protein sequence ID" value="GCB85910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKL4"/>
    <dbReference type="STRING" id="75743.A0A401QKL4"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="145" mass="15401" checksum="E5BA867A64A814CE" modified="2019-05-08" version="1" fragment="single">MEEDPAFRRGRLRWLQQEQQRFQNLQQQQISKRLRKHTGPGRFIPPHDCKLRFPFKSNPEHRYSWGPGSGFGAPSDPGLASDPGLASDPGLASDPGLASDPGLASDPGLPCAPGLASDPGLPSDPGLAAPVAPSPAGQYRVAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM28</accession>
    <name>A0A401QM28_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB86430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM28"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="87" mass="10715" checksum="DC18CDAA23CDD2CC" modified="2019-05-08" version="1">MKEGERECHETKESVRVRKETKMGERERNETKEGERERQERKEGERERNETKEGERERNEMKEGEREQNEMKEGESERKETKEGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMA6</accession>
    <name>A0A401QMA6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMA6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="186" mass="22076" checksum="9DF6BF45EF250B83" modified="2019-05-08" version="1" fragment="single">MQCGIQYGIQYGMQCGILCGIQYEIQCRIKYGMQYEIQYEIHFGIQFGMHVECGMECSVEYCVEYSVECGMKCSVEYCVEYNVEYSVDYSIDCSMKCSVEYCVEYSMECRVEYSMEYSMECSVAYSVECSMEYILEYSMEYSMEYCMDFNVECSMEFSVEYSVECSMEYVLEYSMEYSMEYSMDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMM8</accession>
    <name>A0A401QMM8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01325976">
        <property type="protein sequence ID" value="GCB86659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMM8"/>
    <dbReference type="STRING" id="75743.A0A401QMM8"/>
    <dbReference type="OrthoDB" id="10638306at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="257" mass="31049" checksum="A8752BA6DAD9CACD" modified="2019-05-08" version="1" fragment="single">YTERKPDISQYNFPNKSINYTERKPDISQYNIPNRSINDTERKPDISQYNFPNNSINYTERKPGIREYNFPNNRINYRERKPDISQYNFPNNSIIYTERKSDISEYNYPNHSMNYTERKPGISQYNIPNNNSINYTERKPDISEYNFPNNSINYTERKPDISEYNYPNHSINDTEKTRHQSIQLPQQQQYQLHREKTRHQSRQLPQQQYQLHREKARHQSIQLSHQQYQLHRENQTSVTTAFPTTVSTTQRENQTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNQ2</accession>
    <name>A0A401QNQ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01382238">
        <property type="protein sequence ID" value="GCB87005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNQ2"/>
    <dbReference type="OMA" id="NETMQGE"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="14010" checksum="1A584EE6DC2AEAA1" modified="2019-05-08" version="1" fragment="single">KRAKRDEGGERERNETKEGERERNETKKVKVSETRRRRVKENEKRNKTKEGESERNETKEGEREQSETKVCERERNETMQGEIERNERKEGERERNETKEGERERNKMKEDERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NG62</accession>
    <name>A0A401NG62_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006161">
        <property type="protein sequence ID" value="GCB59917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NG62"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB59917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="314" mass="31431" checksum="25E7EF4CA2A9D861" modified="2019-05-08" version="1">MLTNAVTYGYMTGKVPADGILPAAGIVPAAAGIAPVAAGIVPAVGIVPATGIVPAAASIVVAAAGIVPAAGIVPTAVDIVLTAPNIPTAAGIVPAASVVPAAGIVTAAGIVTFASIVLLLGLFLLLTLFLLLVLPLLLLVVFLLLVLILLLELCLLLLVLFLLLVLLLLLFCCCLHCTCCFFSTAGIVPVTGVVFLPCCWWFIADIVAAADIVLAAVGIVLAAVGIVFAAVGIFLAAGIVPAAVGIILAAGIIPAAGGIVPAAGIFPAAVALFLLLVRYVLLLLFHIGVQYEVTKLLPFLCWKLAAAKCSSRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH44</accession>
    <name>A0A401NH44_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0011077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004920">
        <property type="protein sequence ID" value="GCB60151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH44"/>
    <dbReference type="STRING" id="75743.A0A401NH44"/>
    <dbReference type="OMA" id="NELEPHR"/>
    <dbReference type="OrthoDB" id="5877502at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF21">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB60151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="629" mass="71153" checksum="F685015161A0B039" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH45</accession>
    <name>A0A401NH45_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein zer-1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Zyg-11 homolog B-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zyg-11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002372">
        <property type="protein sequence ID" value="GCB60184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH45"/>
    <dbReference type="STRING" id="75743.A0A401NH45"/>
    <dbReference type="OMA" id="QIRRKHA"/>
    <dbReference type="OrthoDB" id="5783533at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000111">
        <property type="entry name" value="Protein zer-1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="8">
        <location>
            <begin position="198"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="7">
        <location>
            <begin position="406"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="771" mass="88580" checksum="16E24FC9D608A4A0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH67</accession>
    <name>A0A401NH67_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002373">
        <property type="protein sequence ID" value="GCB60207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH67"/>
    <dbReference type="OMA" id="CAPYRIP"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10004">
        <property type="entry name" value="OS06G0538200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10004:SF8">
        <property type="entry name" value="OS06G0538200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="411" mass="41359" checksum="1B1AEB1B8A9F01F9" modified="2019-05-08" version="1">MATQVENVDVMHAAAERAAAEHAAAEHAAAEHAAVERAAAERAAAERAAAEHAAAGRAALECTAAERAAAERAAVERAVAEHAAAVRVAPERAAAEHAAAEHAALERAAAVRVAPEQHAAAVRVAPERAAAEHAAAERAALERAAAEHAALERAAAERAAAERVAPEHAAAEHAAAERAALEPAAAEHAAVERAAEEHAAAVRVAPERAALERAAAECAAAERAAVERAAEEHAAAVRVAPERAALERAAVERAAEEHAAAEHAAAERAALEPAAAERAAAERAAVEHAAAEHAAAVRVAPEHAAAEHAAAERAAPGHAAAERAAAERAALEPAAAERAAVERAAAERAAPGHAAAEHAAAERAALEPAAAEHAAVERAAEEHAAAVRVAPEHAAAEHAAAKRAALERPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH75</accession>
    <name>A0A401NH75_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0009133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the intercrine beta (chemokine CC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003648">
        <property type="protein sequence ID" value="GCB60217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH75"/>
    <dbReference type="STRING" id="75743.A0A401NH75"/>
    <dbReference type="OMA" id="ITSRRIM"/>
    <dbReference type="OrthoDB" id="8870994at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000012">
        <property type="entry name" value="C-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000827">
        <property type="entry name" value="Chemokine_CC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF108">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00472">
        <property type="entry name" value="SMALL_CYTOKINES_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4 9" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018819289" description="C-C motif chemokine" evidence="9">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB60217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="11009" checksum="8C377DB782607E75" modified="2019-05-08" version="1">MSALRKLVVTLLFSMLVLDMLDDSASAMDCCLRYSKKRLPFRLISGYVEQQSNEICDIDAIIFYTIGGQAICANPDSRWVKVALKLLSKKLEEMSLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHT1</accession>
    <name>A0A401NHT1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0014169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007505">
        <property type="protein sequence ID" value="GCB60430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHT1"/>
    <dbReference type="STRING" id="75743.A0A401NHT1"/>
    <dbReference type="OMA" id="ICANTNI"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000010">
        <property type="entry name" value="Thyroid peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF63">
        <property type="entry name" value="EOSINOPHIL PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019366161" description="Sushi domain-containing protein" evidence="4">
        <location>
            <begin position="37"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="580"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB60430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="712" mass="80915" checksum="9B895F8255C1F56F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIB1</accession>
    <name>A0A401NIB1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibrosin-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007534">
        <property type="protein sequence ID" value="GCB60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIB1"/>
    <dbReference type="OMA" id="HPNISAR"/>
    <dbReference type="OrthoDB" id="10060000at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF20">
        <property type="entry name" value="FIBROSIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15336">
        <property type="entry name" value="Auts2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02044">
        <property type="entry name" value="FIBROSIN1LPF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="947"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112284" checksum="9B7CF2088582A826" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIW7</accession>
    <name>A0A401NIW7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0014230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007566">
        <property type="protein sequence ID" value="GCB60820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIW7"/>
    <dbReference type="STRING" id="75743.A0A401NIW7"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF73">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC4-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="405"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="4">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="728" mass="81392" checksum="3D465869A93F272E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ03</accession>
    <name>A0A401NJ03_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0009243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003721">
        <property type="protein sequence ID" value="GCB60854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ03"/>
    <dbReference type="STRING" id="75743.A0A401NJ03"/>
    <dbReference type="OMA" id="CMPLTGP"/>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014839">
        <property type="term" value="P:myoblast migration involved in skeletal muscle regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902723">
        <property type="term" value="P:negative regulation of skeletal muscle satellite cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010592">
        <property type="term" value="P:positive regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010759">
        <property type="term" value="P:positive regulation of macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF9">
        <property type="entry name" value="AKIRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB60854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="184" mass="20740" checksum="C547CA8067485D05" modified="2019-05-08" version="1">MACGATLKRSVEFDALLSPQSQSPKRRRCMPLTGPGAGAPSPQKYLKSEPAAFGGESSSAHRLTPEQIFQNIKQEYNRFQWRRQLEGSFNQSETNSSAEGSPNTLLLNAPSSPGTLSKKDQPLFTLRQVGIICERLLKDHESKIREEYEQVLNTKLAEQYDAFVKFTHDQIMRRYGERPASYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK07</accession>
    <name>A0A401NK07_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005064">
        <property type="protein sequence ID" value="GCB61204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK07"/>
    <dbReference type="STRING" id="75743.A0A401NK07"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="139" mass="14956" checksum="8112EF5BDF28F0D6" modified="2019-05-08" version="1">MSDGDTVKECEESGRDTVKEREVSGGDTVKECEESGGDTLKVREVSGGDTVKEREESGKNTVKEHEERGGYTVKESEVSGGDTVKECEESGGDTVKEREVSDGDTVKEHEESGRDTVKEREVSGGDTVKECEESGGDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLM7</accession>
    <name>A0A401NLM7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylmalonic aciduria and homocystinuria type D protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002515">
        <property type="protein sequence ID" value="GCB61762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLM7"/>
    <dbReference type="STRING" id="75743.A0A401NLM7"/>
    <dbReference type="OMA" id="NGAKEMC"/>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37044" checksum="8704C94CE5717A02" modified="2019-05-08" version="1">MAVGLETVDPDRGGGRWTLPDRRSVQKPSKMAKALCTKARLVTYLPGVHTLVRRIATIRTFSTAGSSGSDEPYIAVMPPDKGLQTIWPDEKMGPFGPQDQRFQLPGNIGFESHINGIANQKRISTHRTLPDVLTEPLTSEKHEFILAQFVNEFQGNEAESQPQEVTTAENYFENAKVECAIQTCPELLRKDFQSMFPDAPVAGFTVLTVTQRSINDMTIWNEAVEEEREQLLEKFISGAKEICYALRSEGYWADFIDPSSGLAYFGPYSNNTLFETDERYRHLGFRIEDLGCCKVIQHKLWGTHVFVGSLFTNAPTDCLVMKKLQGNSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN12</accession>
    <name>A0A401NN12_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin-G-associated kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0007201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002564">
        <property type="protein sequence ID" value="GCB62281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NN12"/>
    <dbReference type="STRING" id="75743.A0A401NN12"/>
    <dbReference type="OMA" id="QDPKNIC"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14564">
        <property type="entry name" value="PTP_GAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000001">
        <property type="entry name" value="cyclin-G-associated kinase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000008">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF34">
        <property type="entry name" value="CYCLIN-G-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="967"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="822"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113838" checksum="50DE7384A47411CA" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNI3</accession>
    <name>A0A401NNI3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007792">
        <property type="protein sequence ID" value="GCB62414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNI3"/>
    <dbReference type="STRING" id="75743.A0A401NNI3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="7956" checksum="300DCACC54922C8A" modified="2019-05-08" version="1">MTAAMDSLQTLSSDTATLAMQQAMMAGHAGDDSLDGTDEDEIEEEEEEEEEDDNGELQTTNVNDLGLDNSDSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNI4</accession>
    <name>A0A401NNI4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0009507</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM231 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003898">
        <property type="protein sequence ID" value="GCB62387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNI4"/>
    <dbReference type="STRING" id="75743.A0A401NNI4"/>
    <dbReference type="OMA" id="PALYTRY"/>
    <dbReference type="OrthoDB" id="426438at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019306">
        <property type="entry name" value="TMEM231"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605">
        <property type="entry name" value="CHST5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10149">
        <property type="entry name" value="TM231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="259" mass="29794" checksum="1011EA2041C512D5" modified="2019-05-08" version="1">MAIYEIYSHPSLVRYKTSVFTKATLFLLIVVALTYIPPLLVAYRSHGFWLKISTYEEQPNVRFQYQVLMIVGTSTSGDFLAWSTFANFNNLQGDNLRFPLVTAMEEDQNLDGKMDRLNFRLELPLQPSEQVYNVQFILTFSYKLFRMSTFMMQSMAYAYFSSSIPGSQFTVNGDLKLHQREPLRHKGVDTRYNVSIFNDGSPFASAYDVARVIASYQDRNVTTTFSNQYPVWTAGRAADAPFVINAVIRYPVEIITYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPZ5</accession>
    <name>A0A401NPZ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Neurotrypsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0011545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005283">
        <property type="protein sequence ID" value="GCB62945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPZ5"/>
    <dbReference type="STRING" id="75743.A0A401NPZ5"/>
    <dbReference type="OMA" id="CTHISTH"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000019">
        <property type="entry name" value="Neurotrypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="226"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="341"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="472"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="157"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="366"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="379"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB62945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57619" checksum="3C5331A35457844B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRB9</accession>
    <name>A0A401NRB9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0009652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01004002">
        <property type="protein sequence ID" value="GCB63364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRB9"/>
    <dbReference type="STRING" id="75743.A0A401NRB9"/>
    <dbReference type="OMA" id="WSSYYEM"/>
    <dbReference type="OrthoDB" id="443524at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB63364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="491" mass="56369" checksum="D8A36BAA006FD338" modified="2019-05-08" version="1" fragment="single">WSYLELSTNGTYNDSIQAYAAGVVEAAVTKQYIYMHWMNTLFHYCGPFKYQTAYCEKLKNYIETNLAWIEDQLARVGDEAYWHQVRLILLQLQGLEDSYNNHVAFPQGKFNIRPFGFILFQMAGDLEDLELVFNKTDSSKAFGSGSCSALIKLLPGNKDLLVSHDTWTNYQTMLRIIKKYKLSFKFTPGGDSPIPGEEQAFSSYPGTLFSGDDFYIMSSRLVALETTIGNNNAHLWKFVQPIGAVMEWIRNLVANRLAESGAEWAGIFKNFNSGTYNNQWMIVDYNYFTPGYFNIKKNLLTILEQIPGQIAIADKTEELMQRGYWASYNIPYFEEIFNASGKQILVQEYGDWFSYNKTPRAQIFRRNQTLVTDMESMVKLMRYNNFKNDPLSECGQCNPKRNGENSISARSDLNPANGTYPFSALGQRSHGGTDMKVTSFELHKTYQMIAVNGPTWDEVPAFQWSKSPFSKLMHMGHPDLWKFLPVLVQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS49</accession>
    <name>A0A401NS49_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0007429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002692">
        <property type="protein sequence ID" value="GCB63743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS49"/>
    <dbReference type="STRING" id="75743.A0A401NS49"/>
    <dbReference type="OMA" id="NIFQFPS"/>
    <dbReference type="OrthoDB" id="311720at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB63743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13191" checksum="30E91D598D6D827C" modified="2019-05-08" version="1">MSLYSSLPHNISQSLTKFGGSLFIGNKTRDSGGGHTSIPANEMVSSLPLQMALYFNVFFFPFWWVSEVTMLQLKYSMLPGYYQWLLLAAVIILTLIECVRLFLGYLGNLQEKVSALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT46</accession>
    <name>A0A401NT46_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0014714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008001">
        <property type="protein sequence ID" value="GCB64032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT46"/>
    <dbReference type="STRING" id="75743.A0A401NT46"/>
    <dbReference type="OMA" id="KMRHVGI"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB64032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="11498" checksum="52DBEA186D56BCCD" modified="2019-05-08" version="1">MGDPEKGKKIFVQKCVVCHTIEKGGKHMVGPNLWGLFGRKTGSAAGFTYTDANKTKGITWGENTLMDYLENPKKYIPGTKMLFAGIKKKNERADLIAYLKQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUC2</accession>
    <name>A0A401NUC2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0007536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPSB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002753">
        <property type="protein sequence ID" value="GCB64440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUC2"/>
    <dbReference type="STRING" id="75743.A0A401NUC2"/>
    <dbReference type="OMA" id="CHHDSEN"/>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03718">
        <property type="entry name" value="SOCS_SSB1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF8">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30893" checksum="80D5F8D7C331BC23" modified="2019-05-08" version="1">MGQRVTVGLKTVDVRDPSYRPLRHEQQGLDYCKPTRLDMLLDMPPATCEVQLLHSWNNDDRSLNVFVKEDDKLIFHRHPVAQSTDGIRGKVGYTRGLHVWEITWAMRQRGTHAVVGVATIDAPLHSVGYTALVGSNCESWGWDLGRNKLHFDGKNQPSQTYPAFLEPHETFIVPDVFLVVLDMDEGTLSYIVDGHYLGVACRGLKGKKLYPVVSAVWGHCEIRMRYINGLDPEPLPLMDLCRRSVRVALGKDHLNEIHSLPLPASLKSYLLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVI6</accession>
    <name>A0A401NVI6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000064">
        <property type="protein sequence ID" value="GCB64879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVI6"/>
    <dbReference type="STRING" id="75743.A0A401NVI6"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="110" mass="12518" checksum="C4794B3887BB611B" modified="2019-05-08" version="1">MADEDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGSRNTPAGIQEGEPFSEDATQFTKELVLQHEWQDEGEKMSKFLLFLALLQLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVV8</accession>
    <name>A0A401NVV8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WDR72-like alpha-solenoid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002804">
        <property type="protein sequence ID" value="GCB64997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVV8"/>
    <dbReference type="STRING" id="75743.A0A401NVV8"/>
    <dbReference type="OMA" id="NETHCTM"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057848">
        <property type="entry name" value="WDR72_alpha-sol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF2">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23123">
        <property type="entry name" value="WDR72_alpha-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR72-like alpha-solenoid" evidence="3">
        <location>
            <begin position="234"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB64997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="438" mass="49223" checksum="C72990DBDE0472C9" modified="2019-05-08" version="1">MLLYRTCAEPCCIGCDQSAFPEPTLQPFTVLPVKTKWSDSTIHVLLFDISAICEQLLVYQGKEPKLQNAVQNHETLKRLTNIDGKKPPMSLKRNKTIAPPCQTNGSVKDSVREHLFYSENNTNGLAREGAGISKQKTKPKGAKRVATSAVKKMDVNMARDTAKLLISCLFPWGVDRDLDELCMKHLGMFEPRCPVSFGLLSQDDYLSLLLPGWYQVNREVIKDCVFCSKISNKVVELAKQVSNITQAHAVSMAETLNDGAEGNFQSEMTSYLLSVILLVNIQMKMPFLSKGNETHCTMRQQKGDFQRGKGDTSQPSIPALPGEMMQNRTFYPSSSLSKEKNFDILSNLIASWQVQSVELLEAIQAMLLAEVQRVFRTLRKKPISRQPVIRAQNGSSEAQTILQTEHVELRDTQQNASTVMPNRLREWPMSRICFCKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWL6</accession>
    <name>A0A401NWL6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAST kinase domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein TBRG4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transforming growth factor beta regulator 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAST kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001426">
        <property type="protein sequence ID" value="GCB65258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWL6"/>
    <dbReference type="STRING" id="75743.A0A401NWL6"/>
    <dbReference type="OMA" id="LCILQQA"/>
    <dbReference type="OrthoDB" id="6501018at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23739">
        <property type="entry name" value="TBRG4-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF59">
        <property type="entry name" value="FAST KINASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019410894" description="FAST kinase domain-containing protein 4" evidence="8">
        <location>
            <begin position="27"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="RAP" evidence="9">
        <location>
            <begin position="529"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB65258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="599" mass="67796" checksum="8A0214D358A269BC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWR3</accession>
    <name>A0A401NWR3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Protogenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0004756</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in anteroposterior axis elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily. DCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001428">
        <property type="protein sequence ID" value="GCB65300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWR3"/>
    <dbReference type="STRING" id="75743.A0A401NWR3"/>
    <dbReference type="OMA" id="AAQIINY"/>
    <dbReference type="OrthoDB" id="438268at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050768">
        <property type="term" value="P:negative regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000930">
        <property type="entry name" value="immunoglobulin superfamily DCC subclass member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000189">
        <property type="entry name" value="Neogenin isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000828">
        <property type="entry name" value="Protogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000987">
        <property type="entry name" value="Protogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000455">
        <property type="entry name" value="Protogenin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000551">
        <property type="entry name" value="Protogenin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000299">
        <property type="entry name" value="protogenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000456">
        <property type="entry name" value="protogenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF47">
        <property type="entry name" value="PROTOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="127"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="226"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="413"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="509"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="610"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="716"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="814"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1104"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB65300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="133548" checksum="3156C902D42CC228" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZF3</accession>
    <name>A0A401NZF3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0010072</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the connexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004270">
        <property type="protein sequence ID" value="GCB66235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZF3"/>
    <dbReference type="STRING" id="75743.A0A401NZF3"/>
    <dbReference type="OMA" id="NWANMAA"/>
    <dbReference type="OrthoDB" id="9930281at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000002">
        <property type="entry name" value="Gap junction protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034634">
        <property type="entry name" value="Connexin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031862">
        <property type="entry name" value="Cx40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF12">
        <property type="entry name" value="GAP JUNCTION ALPHA-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16791">
        <property type="entry name" value="Connexin40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118220">
        <property type="entry name" value="Connexin43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0303">Gap junction</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="14">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="15">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB66235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="391" mass="44291" checksum="6974C6AB0A95DF0F" modified="2019-05-08" version="1">MGDWSFLGRLLENAQEHSTVVGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCENVCYDKAFPISHIRFWVLQIIFVSTPTLIYLGHVLHIVRMEDKRKEREEDIRKAQSQADKELLLKNGKKKLPFRDDHGKIRIQGALLRTYVFNIIFKAMFEIGFILGQYILYGFELRPLYRCDRWPCPNTVDCFISRPTEKTIFILFMLVVACVSLFLNLMEIYHLGWKKLRQGVTNRQTPHLEQKPEPLTPVTRTVPSTFSYPYFPDAAEGPNPYPGAPPTEFKMAPLSEDRSPYVVYNNKLAAEQNWANMAAEQTRQLIPDASNGKQEHALPAPANQESAPVGGAARGNGHLTTTVEMHEPPANDTRPLSRASRASSGRARSDDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P052</accession>
    <name>A0A401P052_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0000602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000111">
        <property type="protein sequence ID" value="GCB66480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P052"/>
    <dbReference type="OMA" id="FAWREGQ"/>
    <dbReference type="OrthoDB" id="306254at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028750">
        <property type="entry name" value="CEP350/CC187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958:SF3">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN 350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="2364"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="67"/>
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    </feature>
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        </location>
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        <location>
            <begin position="1117"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1774"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1779"/>
            <end position="1792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB66480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2918" mass="325409" checksum="F0BC6CD6D7F9CA34" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0R7</accession>
    <name>A0A401P0R7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002959">
        <property type="protein sequence ID" value="GCB66700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0R7"/>
    <dbReference type="STRING" id="75743.A0A401P0R7"/>
    <dbReference type="OMA" id="SANEDEX"/>
    <dbReference type="OrthoDB" id="10045773at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23817">
        <property type="entry name" value="RWD-RWDD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042770">
        <property type="entry name" value="RWDD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275:SF1">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="179" mass="20369" checksum="E8010CFDCA3A502B" modified="2019-05-08" version="1">MTANEEQTMELEALRSIYEGDECFKELCPASFQYRVGNRGDPKAFLLEISWPEMYPELPPNISLNAFFNNSISSSIKQNIIGKLQEQVEANLGTAMVYTLFEWAKENQEQLMENHHPVVGAMTASLTENTVISNSSVAKKKEKKEQLSKSQKKKLADKTDNRGELPRGWNWVDVIKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1R2</accession>
    <name>A0A401P1R2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0010188</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01004341">
        <property type="protein sequence ID" value="GCB67040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1R2"/>
    <dbReference type="STRING" id="75743.A0A401P1R2"/>
    <dbReference type="OMA" id="YSACKVE"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000014">
        <property type="entry name" value="Histone acetyltransferase KAT2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 14" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="410"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="647"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB67040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="740" mass="85052" checksum="0D735CF90D4F85EF" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1U7</accession>
    <name>A0A401P1U7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002987">
        <property type="protein sequence ID" value="GCB67063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1U7"/>
    <dbReference type="STRING" id="75743.A0A401P1U7"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000092">
        <property type="entry name" value="Calcipressin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF6">
        <property type="entry name" value="CALCIPRESSIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11497" checksum="D1A2C995586B39D1" modified="2019-05-08" version="1">MPVQKMEWELVVLVACEVNEQIFTNQEVQERFEALFRVYDEQATFQLFQSFQRVRINFSSQEAAARARIELHESDFNGSKLKLYFAQVQSCNLTKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P204</accession>
    <name>A0A401P204_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras association domain-containing protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">New ras effector 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0007994</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, MRAS, RAP1B, RAP2A and RALA. Interacts with RRAS2. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS. Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002992">
        <property type="protein sequence ID" value="GCB67117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P204"/>
    <dbReference type="STRING" id="75743.A0A401P204"/>
    <dbReference type="OMA" id="ECRGLIQ"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21892">
        <property type="entry name" value="SARAH_RASSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000048">
        <property type="entry name" value="Ras association domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000032">
        <property type="entry name" value="Ras association domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF9">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ras-associating" evidence="13">
        <location>
            <begin position="112"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="14">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB67117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="259" mass="29742" checksum="1C4AD7DD3F61F3CF" modified="2019-05-08" version="1" fragment="single">THQVCKNFIKLDCQQAEQFSEEKICPEDTVVQPGSENVTPKEEKPKVLTEKEIKRKIEEYNGKAKNCLGMRLNPDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDVLKEVNPAEITNKRTSFYLPLDAIKQLHISSVTTVNEVITGLLKKFMVIDNPQKFALFYQTKKGNDVHLQKLKENEHPLLIRLLAGPDTTVSNFALKENETGEVEWDAFSVPELQNFLIILEKEEKERIQQVQQKYITFRQRLEKALKEVGKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P249</accession>
    <name>A0A401P249_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0010212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004356">
        <property type="protein sequence ID" value="GCB67192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P249"/>
    <dbReference type="STRING" id="75743.A0A401P249"/>
    <dbReference type="OMA" id="SHCECYE"/>
    <dbReference type="OrthoDB" id="5988548at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF63">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="12">
        <location>
            <begin position="146"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB67192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="484" mass="56150" checksum="BB440386A74FDDBB" modified="2019-05-08" version="1">MGSIRFHYFCYGCLFSSLIWTFLLFIYFNLNWEKYTFSNVPFQGNPGLMQKFKPPITHSPEWVPEFQKHGVQFMKPIRNELKKIELFPELGRIFNEADLEVRDMGYQKHAFNMLISNRLGYHRDIPDSRDPKCKEKSYPVNLPSASIIICFYNEALSALLRTLHSILDRTPAYLLHEIILVDDRSDFVELKDELEKYIDNNQLKKVKLIRNVMREGLIRGRMVGSSHATGDVLVFIDSHCEVNKMWLQPLLTLIKEDSSTVVCPLIDIINADTLIYSSSPIVKGGFNWGLHFKWDPVPVSLLNGPGATEPFKSPTMAGGLFAMNRDYFNKLGQYDSGMDIWGGENLEISFRIWMCGGQLKIVPCSRVGHIFRKWRPYGSPGGTDTMAYNSLRLSHVWMDEYKEQYLSLRPDLRKQSYGDITERLNLRKKLNCTSFKWYLDNVYPEMNVNGPNERAKIQQPLFINKSPKRSKILQQGRVRFNRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2F1</accession>
    <name>A0A401P2F1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005759">
        <property type="protein sequence ID" value="GCB67314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2F1"/>
    <dbReference type="STRING" id="75743.A0A401P2F1"/>
    <dbReference type="OMA" id="CAHIAYS"/>
    <dbReference type="OrthoDB" id="10072648at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031447">
        <property type="entry name" value="MNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15732">
        <property type="entry name" value="PROTEIN MOONRAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15732:SF4">
        <property type="entry name" value="PROTEIN MOONRAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15718">
        <property type="entry name" value="MNR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="658" mass="74767" checksum="B7B0B79C656D46B6" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2L0</accession>
    <name>A0A401P2L0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucoside xylosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.2.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glycosyltransferase 8 domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0010236</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1-&gt;3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56064"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:14611"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:140575"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
            <dbReference type="EC" id="2.4.2.42"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.42" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01004370">
        <property type="protein sequence ID" value="GCB67337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2L0"/>
    <dbReference type="STRING" id="75743.A0A401P2L0"/>
    <dbReference type="OMA" id="IPIHKEY"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140563">
        <property type="term" value="F:UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06430">
        <property type="entry name" value="GT8_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000042">
        <property type="entry name" value="Glucoside xylosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051993">
        <property type="entry name" value="Glycosyltransferase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46012:SF3">
        <property type="entry name" value="GLUCOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46012">
        <property type="entry name" value="IP22168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019040533" description="Glucoside xylosyltransferase 1" evidence="15">
        <location>
            <begin position="38"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB67337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="521" mass="60331" checksum="5E9E1482C75ED810" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2Y7</accession>
    <name>A0A401P2Y7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Anthrax toxin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0005138</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001573">
        <property type="protein sequence ID" value="GCB67477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2Y7"/>
    <dbReference type="STRING" id="75743.A0A401P2Y7"/>
    <dbReference type="OMA" id="CCMVVIK"/>
    <dbReference type="OrthoDB" id="10035766at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01474">
        <property type="entry name" value="vWA_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000024">
        <property type="entry name" value="Anthrax toxin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017360">
        <property type="entry name" value="Anthrax_toxin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008399">
        <property type="entry name" value="Anthrax_toxin_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008400">
        <property type="entry name" value="Anthrax_toxin_rcpt_extracel"/>
    </dbReference>
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        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059">
        <property type="entry name" value="ANTHRAX TOXIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059:SF13">
        <property type="entry name" value="ANTHRAX TOXIN RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05586">
        <property type="entry name" value="Ant_C"/>
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    </dbReference>
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        <property type="entry name" value="Anth_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038023">
        <property type="entry name" value="Anthrax_toxin_receptor_2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019443471" description="Anthrax toxin receptor" evidence="17">
        <location>
            <begin position="39"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="48"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038023-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB67477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="493" mass="54344" checksum="8924A2D4700F6A75" modified="2019-05-08" version="1">MRPWRTVAVHHRICPGIRSFVFFVSAFLILTGPGTVQSEEKSCHGAFDLYVVLDKSGSVANNWDEIYGFVEALVKRFVSPQMRLSFIVFSSRADVKMAITSNRKEINDGLAALKNVIPAGDTYMHLGIKAASQQIMKQKDLKTVSAIIVLTDGELVELVLPYTIREADDARKLGAVIYCVGVKDFKEQQLEKVADSPNHVFPVNGGFQALKGIIDLILKKSCTEVLEVEPSSACAGQEFEVVLRGNGFMAGRGTDLILCRYYINASTILTERPSIKATDNYLLCPAPVLQEVGQTMDVSVSLNDGQSFISSSVTITATACSDGTAVLIAIFTILLLLGIALLWWFWPLCCMVVIKDPPPPPPPRKEEPEPDPVAKSKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTDEGARLEMAKNAVVTVPDVEEEPLAPRQPKLPPSNYPPSTQWYDPIKGRLDALWALLRRQYHLVSLMRPQTGDEGRCINFSRVQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3R8</accession>
    <name>A0A401P3R8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0015155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008455">
        <property type="protein sequence ID" value="GCB67774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3R8"/>
    <dbReference type="STRING" id="75743.A0A401P3R8"/>
    <dbReference type="OMA" id="RICCNEI"/>
    <dbReference type="OrthoDB" id="6766775at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="3">
        <location>
            <begin position="2"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="336" mass="39443" checksum="F3E1887103D1D86C" modified="2019-05-08" version="1" fragment="single">STIKFNTILTENRKLREEINILRVNKEIYTKLYNKLSTKLQEQKKIMKEIVEESVQAYDQRMEAETRIHAVKERSAKDILLYNTEIKELMRIIDHEAKLKDFMLIKFRQLTREDHSKDKVGKKTAQEIEYEAYEEVHNQLKHVTGKDNLYSLGPEFVATEEKNYALFNFINEINIQLEQKQEKIQNIKNDILQIENQRRQSEEDLHDRIKEIEDNLESTTQQINKYEIMQTQVNKTLDELKSGIEPISKKIHCDLTPIQQKLCGNEGILDYNALNYLVGRTTHQEHASDIQAYDEKVITDTPDVFLTCWDCCVGKLALQYLDSSSINAKVVKTINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3S4</accession>
    <name>A0A401P3S4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0012190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005812">
        <property type="protein sequence ID" value="GCB67805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3S4"/>
    <dbReference type="STRING" id="75743.A0A401P3S4"/>
    <dbReference type="OMA" id="KMDLHAE"/>
    <dbReference type="OrthoDB" id="6145717at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031650">
        <property type="entry name" value="CCDC73"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15818">
        <property type="entry name" value="CCDC73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="687" mass="76081" checksum="865813C5DEB2F17E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P671</accession>
    <name>A0A401P671_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01004495">
        <property type="protein sequence ID" value="GCB68625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P671"/>
    <dbReference type="STRING" id="75743.A0A401P671"/>
    <dbReference type="OMA" id="GESNDWG"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF25">
        <property type="entry name" value="CARBONIC ANHYDRASE 5B, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB68625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="295" mass="33574" checksum="FCB53523C24E0DA6" modified="2019-05-08" version="1">MVFSFRAIQAFLKRFPVRDLWIPMRNCNLACCTQNINKAKQQERQNPVPVPSGVRQSPIDISTDDSVYDPQLKPLKISYDPSNCLLLRNNGYFFQVEFEDSKDSSVISSGPLKNQYRLKQFHFHWGSKSDRGSEHTVNNQVYPAELHLVHWNPVKCNNSGEAILSENGLAVVGVFLKLGKRHDSLQKLVDALPAVKHKDAAVDFFNFDPACMIPPCSDYWTYPGSLTAPPLTECVTWVIMKDPIEVSPDQLAMFRSLFYTSVGEKQKNMVDNYRPVQPLMKRTVYSTIPSFHNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P690</accession>
    <name>A0A401P690_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001649">
        <property type="protein sequence ID" value="GCB68628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P690"/>
    <dbReference type="STRING" id="75743.A0A401P690"/>
    <dbReference type="OMA" id="LMHIVFF"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015650">
        <property type="term" value="F:lactate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17430">
        <property type="entry name" value="MFS_MCT3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000077">
        <property type="entry name" value="Proton-coupled monocarboxylate transporter 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004743">
        <property type="entry name" value="MCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00892">
        <property type="entry name" value="2A0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF27">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB68628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="469" mass="50621" checksum="967ED59BBBC21935" modified="2019-05-08" version="1">MGAIVADDGPPTVKAPDGGWGWAILIGSFVITGFSYAFPKAVSVFFKELIKEFHIGYSDTAWISSILLAMLYGTGPLCSVLVNRFGCRPVMMVGGLFASAGMILASLCTSIIQVYMTAGVITGLGLALNFQPSLIMLNRYFDQRRPLANGLSAAGSPVFLCCLSPLGQTLSKKFGWRGGFLILGGLLLNCCACAALMRPLKPTRKEQEKIDQAKKMQEGKKKKLLDFSVFKDRGFLIYTIAASIMVFGLFVPPVFIVNYAKDTGVPDTDAAFLLTILGFVDIFARPFCGVLAGLKQVRPRCVYLFSFAMIFNGITDLGGSFSQGYGGLTVFCIFFGMSYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAMAVLVGPPGAGKLFDTTKNFKHVFYLAGSEVVLSAFVLAIGNFFCLHKSTEPPAKEQKENEEEGEQKRETADSIEVDQFLKDETGNNGEIVPTPETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6A9</accession>
    <name>A0A401P6A9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0005343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001651">
        <property type="protein sequence ID" value="GCB68657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6A9"/>
    <dbReference type="STRING" id="75743.A0A401P6A9"/>
    <dbReference type="OMA" id="AFDWSTH"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB68657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16611" checksum="006705D976DCA523" modified="2019-05-08" version="1">MRGLPELMWAGSAIWKNVEDFTGPRERSDLGLITFDLSADLKPIFDWNVKQLFLYLSAEYKTKNNALNQVVLWDKIVLRGDKTKLDLKDVKSKYFFFDDGNGLKGNENITLTLSWNVVPNAGILPLVTGSGHSSAAFPDSYEMTKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7W2</accession>
    <name>A0A401P7W2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcobalamin-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0012376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic cobalamin transport proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005962">
        <property type="protein sequence ID" value="GCB69160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7W2"/>
    <dbReference type="STRING" id="75743.A0A401P7W2"/>
    <dbReference type="OMA" id="QCVKDSG"/>
    <dbReference type="OrthoDB" id="9440006at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027954">
        <property type="entry name" value="Transcobalamin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14478">
        <property type="entry name" value="DUF4430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcobalamin-like C-terminal" evidence="10">
        <location>
            <begin position="304"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="350"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="382" mass="43657" checksum="0A2DE019CA094B09" modified="2019-05-08" version="1" fragment="single">VKIFTNWFKCVSCNYHKEVFFLKNIMQPRRLLLISCMQALFLTVRLRPSTGLVALYLLALRASCEDLDSLQEALPYLKNKLRAEKSHTNHHNVPLTNLYQYSLGVLALCVNNVRVDHSVLSGLMPHEHHHHWIDTEAMMVLALKCVHESKVPNNDTWMYSDARRTKVQTAMNKLIQKIQNRQAENGKIGNIYSTSVALQALLAVRDKARWLKGKEKLLIEAQKGAFHNPMALSQLLPVLHEKTYLDIGQMDCSKERDGQKHSHSVTASHQTEPNSTRQTGFVNLTVRNINRAVVYTAELPLYQGTSLLGVLNEAKRNDTNFNFETKQTLWGPFLTSVHHLKAQDTARTYWHLITGENTPLKKGIKDYHPQPGEHILLQLSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8T3</accession>
    <name>A0A401P8T3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flotillin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0012437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006007">
        <property type="protein sequence ID" value="GCB69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8T3"/>
    <dbReference type="STRING" id="75743.A0A401P8T3"/>
    <dbReference type="OMA" id="MGNVQTV"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045661">
        <property type="term" value="P:regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000003">
        <property type="entry name" value="Flotillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="133"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="474" mass="52557" checksum="B4BA4EEAD2EC6E07" modified="2019-05-08" version="1">MYSELVNSFVLMLFGNLGHFYKTVRLMQISNKLGNNEDKSSKWGETCIYLQRRWEPAMIQEDGGCCGSDQKQYVIGGWAWAWWCVSQTQRISLEIMTLQPKCEDVETAEGVALTVTGVAQVKVMTEMELLAVACEQFLGKSVQETKSVVLQTLEGHLRAILGTLTVEAIYQDRDQFAQLVREVAAPDVGRMGIEILSFTIKDVYDKVEYLSSLGKSQTAIVQRDAEIGVAEAERDAGIREAECKKEAMDVKYSADTKMADSKRAFEMQKASFNQEINMKKAEAQLAYELQGAKEQQKIRQEEIEIEVVQRKKQIDIEEKEIARMDKELIGTVKRPAEAEAFRMQQIAEGQKVKQVLIAQAQAEKIRKIGEAEASSISAIGKADAEKMRLKAAAYQQYGNAAKVALVLNALPKIAAEVTAPLAKTDEIVILGGDSNRVTSEITRLLAEVPASVHALTGVDLTKVPLIQKLTNAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAT3</accession>
    <name>A0A401PAT3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A</fullName>
            <ecNumber evidence="17">2.4.1.145</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">scyTo_0005635</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-{alpha-D-Man-(1-&gt;6)}-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-{alpha-D-Man-(1-&gt;6)}-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69631"/>
            <dbReference type="Rhea" id="RHEA-COMP:17739"/>
            <dbReference type="Rhea" id="RHEA-COMP:17740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:187880"/>
            <dbReference type="ChEBI" id="CHEBI:187881"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:69632"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16057"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="EC" id="2.4.1.145"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16058"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69635"/>
            <dbReference type="Rhea" id="RHEA-COMP:17741"/>
            <dbReference type="Rhea" id="RHEA-COMP:17742"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:187882"/>
            <dbReference type="ChEBI" id="CHEBI:187883"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:69636"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = an N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69615"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="Rhea" id="RHEA-COMP:17732"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:187873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:69616"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = an N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69627"/>
            <dbReference type="Rhea" id="RHEA-COMP:17737"/>
            <dbReference type="Rhea" id="RHEA-COMP:17738"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:187878"/>
            <dbReference type="ChEBI" id="CHEBI:187879"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69628"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = an N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69619"/>
            <dbReference type="Rhea" id="RHEA-COMP:17733"/>
            <dbReference type="Rhea" id="RHEA-COMP:17734"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:187874"/>
            <dbReference type="ChEBI" id="CHEBI:187875"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:69620"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69623"/>
            <dbReference type="Rhea" id="RHEA-COMP:13532"/>
            <dbReference type="Rhea" id="RHEA-COMP:18198"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137207"/>
            <dbReference type="ChEBI" id="CHEBI:187877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:69624"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.145" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01001780">
        <property type="protein sequence ID" value="GCB70230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAT3"/>
    <dbReference type="STRING" id="75743.A0A401PAT3"/>
    <dbReference type="OMA" id="ELERHWI"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008454">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF4">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MGAT4 conserved region" evidence="29">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="30">
        <location>
            <begin position="221"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00093220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00093225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00093235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00093244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="GCB70230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="365" mass="42001" checksum="C9E3EF91EF7C232D" modified="2019-05-08" version="1">MCTAAATDLDYVHSVVGSLEKEFFAEINAGLIEVISPPSAYYPDLTNLKETFGDSKERVRWRTKQNLDYCFLMMYAQKKGIYYVQLEDDIVAKDHYFSTMKNFALQLASEDWMVLEFSQLGFIGKMFQSPDLNLIVEFILMFHKEKPIDWLLDHVLWVKVCNPEKDAKHCERQRSNIRIRFRPSLFQHVGLHSSLAGKIQKLTDKDFMKPLLHKMHVNPPAEVSTSLKAYQGHSLDKAYLGEDFFWGITPLAGDYILVKFDKPLNIDRYLFHTGNTEHPGDLLLNTSVEILPYKDSGSELLQETKESRNKRTEDGFFRIGRFANGVAEGAIDQRMNPITAIRLSVLQDSNVWVLLDEIQLKKAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAU9</accession>
    <name>A0A401PAU9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">5-hydroxytryptamine receptor 3A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">5-hydroxytryptamine receptor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Serotonin receptor 3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Serotonin-gated ion channel receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">scyTo_0001229</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3B or HTR3C or HTR3D or HTR3E. The homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo. Interacts with RIC3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000267">
        <property type="protein sequence ID" value="GCB70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAU9"/>
    <dbReference type="STRING" id="75743.A0A401PAU9"/>
    <dbReference type="OMA" id="SENEGEW"/>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19063">
        <property type="entry name" value="LGIC_TM_5-HT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000020">
        <property type="entry name" value="5-hydroxytryptamine (serotonin) receptor 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000017">
        <property type="entry name" value="5-hydroxytryptamine receptor 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008132">
        <property type="entry name" value="5HT3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008133">
        <property type="entry name" value="5HT3_rcpt_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049944">
        <property type="entry name" value="LGIC_TM_5-HT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01709">
        <property type="entry name" value="5HT3ARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01708">
        <property type="entry name" value="5HT3RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 27" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 27" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 27" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="29">
        <location>
            <begin position="17"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="30">
        <location>
            <begin position="232"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00068982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00078864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00080492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00083210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="GCB70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="377" mass="43690" checksum="92A08121BEEAEE32" modified="2019-05-08" version="1">MKKSGNQTAGPTPGLLQLSDYLMANYSKGVRPVRDWRKTTTVAIDVMVYAILNVDEKNQVLTTYIWYRQVWTDEFLMWNPKDFDDIKQISIPTANIWVPDILINEFVDVGKSPEIPYVYVDNGGRVKNYKPIQVVTACSLDIYNFPFDVQNCTFTFTSWLHNIRDINISLWRSPEVVKYDRSVFMNQGEWELLYVDTQFNEFNLERGVSDGYAEMRFFLVIRRRPLFYAVSLLLPSIFLMVMDIIGFYLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLTETILIVRLVHKQDLQPHVPEWVKRLVLEKATILLCLRNKKWFHSTSQNSETPENPRDRKGSTGWWNKRQGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF53</accession>
    <name>A0A401PF53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0001697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000390">
        <property type="protein sequence ID" value="GCB71763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5984008at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="39"/>
            <end position="248"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB71763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="257" mass="29696" checksum="6D34999D216697A5" modified="2019-05-08" version="1">MMERIGPIFEMLEGTSLVCWMAFHRGIFELVEGGTVGAEELAFKFAVNNINRNRTLLPNTTLTYDIQRINIYDSFEASRKACDQLSLGVVAIFGPSHSSSSNAVQSICNALEVPHIQIRWKHHPMDNRDSFYTNFYPNYSSLSHAILDLVQFLKWRTATVVYDDSTGLIRLQELITAPSRYNIRLKIRQLPIDSTDARPLLKEMKRGREFRIIFDCSYTMAAQILKQAMSMGMMTEYYHYIFTTLVINFSDLFEHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFK6</accession>
    <name>A0A401PFK6_SCYTO</name>
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        <recommendedName>
            <fullName evidence="4">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PFK6"/>
    <dbReference type="OMA" id="CTIWRRN"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="66362" checksum="4D2A22F9D660D97E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG98</accession>
    <name>A0A401PG98_SCYTO</name>
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        <recommendedName>
            <fullName evidence="3">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="75743"/>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000432">
        <property type="protein sequence ID" value="GCB72170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="SHEGEAN"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Doublecortin domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Doublecortin domain containing 2B"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF9">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Doublecortin (DC)"/>
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    </dbReference>
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        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="3">
        <location>
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            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB72170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="543" mass="61187" checksum="3391010192965688" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401PH24_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
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        <name type="common">Cloudy catshark</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
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            <taxon>Carcharhiniformes</taxon>
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            <taxon>Scyliorhinus</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000468">
        <property type="protein sequence ID" value="GCB72433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH24"/>
    <dbReference type="STRING" id="75743.A0A401PH24"/>
    <dbReference type="OMA" id="DDNCTSG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000017">
        <property type="entry name" value="TBC1 domain family member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.230:FF:000002">
        <property type="entry name" value="TBC1 domain family member 16 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000020">
        <property type="entry name" value="TBC1 domain family, member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF547">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="494"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB72433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="833" mass="95605" checksum="0B25D798113F452D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHB5</accession>
    <name>A0A401PHB5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0002041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000487">
        <property type="protein sequence ID" value="GCB72522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHB5"/>
    <dbReference type="STRING" id="75743.A0A401PHB5"/>
    <dbReference type="OMA" id="SWNMPIT"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB72522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8978" checksum="7AD26B6C8DC32C2A" modified="2019-05-08" version="1">MVLLPSGSPHILTVFWGVVDGVVPWFISKGSNRGVINTMMVTSAVCCYLFWLIAILSQLNPLFGLQLKNETIWYLRHNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHR8</accession>
    <name>A0A401PHR8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0002124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000512">
        <property type="protein sequence ID" value="GCB72676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHR8"/>
    <dbReference type="OMA" id="WPWAFEA"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF2">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="35"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB72676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="27143" checksum="011EFAF56B15CDD7" modified="2019-05-08" version="1">MEWNPGALIVGVSFGGFKLINRGLGYVPAPESALRNTWKWRNICTSMLHSVVTGIWSVLCFYIHPRMAEDLIDTHSPSSHGLVSLSIGYFIHDFTDLLWNQKCQNSWELLFHHAVVITCFGTSVSLCSYIGFAVVALLVEINSIFLHLRQILLMANMCQTTCFRINSIINLGTYVIFRISTLAWMTRWLVLNRNNVPLVIYTIGSVGLTIMTMMNIVLFYRLLRSDFLKSSREGKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI13</accession>
    <name>A0A401PI13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-glucosylgalactosylhydroxylysine glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.107</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acid trehalase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0002183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(5R)-5-O-[alpha-D-glucosyl-(1-&gt;2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:11068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12753"/>
            <dbReference type="Rhea" id="RHEA-COMP:12754"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:133443"/>
            <dbReference type="ChEBI" id="CHEBI:133452"/>
            <dbReference type="EC" id="3.2.1.107"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.107" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01000528">
        <property type="protein sequence ID" value="GCB72772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI13"/>
    <dbReference type="STRING" id="75743.A0A401PI13"/>
    <dbReference type="OMA" id="WTSVPDH"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047402">
        <property type="term" value="F:protein-glucosylgalactosylhydroxylysine glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000023">
        <property type="entry name" value="Protein-glucosylgalactosylhydroxylysine glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.420.10:FF:000003">
        <property type="entry name" value="Protein-glucosylgalactosylhydroxylysine glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="10">
        <location>
            <begin position="305"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB72772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="718" mass="80800" checksum="B1C187F3DB30D691" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ91</accession>
    <name>A0A401PJ91_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002291">
        <property type="protein sequence ID" value="GCB73203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJ91"/>
    <dbReference type="STRING" id="75743.A0A401PJ91"/>
    <dbReference type="OMA" id="CAFFNDV"/>
    <dbReference type="OrthoDB" id="9944532at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053072">
        <property type="entry name" value="BEN_domain_protein_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35068">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35068:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40887" checksum="0DBB94D99608B02A" modified="2019-05-08" version="1">MELTERERSRKSRSFKRVNEDYQDDNHSDSSNENTGRAHDVLSVTGDVCEGLKKQVSGMRCLLNNKVNSIGIHQPLMPGREKLKVELGASDLTWLQHNTHQTNVRLDEPHSSQSIVWKDIQVPTQNSCVSGRYSGEDSRSSKPVIDAITERLQGMPESNGRSYSTLGSNCCMCSCQPTLLAILQELRTLRELMQGQAGPQGTMHVPLSHSNNFRSSLLRTKIIKKRLIHRNKPAAAQANPKIHNPDISLPQTERNRSIPTKRLTTENNPRQAPPNGVEGYISELDSRQNSDLFKIDRLPGPTDWIQILQDQIARARNRLKRGAVLQPFESSGKMGSNFLLNTGASTNTASSSDRWDASEPVCTVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJI6</accession>
    <name>A0A401PJI6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000613">
        <property type="protein sequence ID" value="GCB73261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJI6"/>
    <dbReference type="OrthoDB" id="9950396at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12413" checksum="D7895875B4163FD3" modified="2019-05-08" version="1">MEINKAHAKIRFDAFKTVNRIGANSQKWYGAKPQGTIGTLLQILPHQEYKDAEEDEPIPKLPSATVRMDTNHWIAFSVKNTVAKPLNQKTANTSAAKESPEHKRKGSPYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJM7</accession>
    <name>A0A401PJM7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000620">
        <property type="protein sequence ID" value="GCB73315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PJM7"/>
    <dbReference type="OMA" id="NMSFECL"/>
    <dbReference type="OrthoDB" id="9995375at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20436">
        <property type="entry name" value="Tudor_TDRD15_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047450">
        <property type="entry name" value="Tudor_TDRD15_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF7">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="60"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="297"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="527"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="801"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="1860"/>
            <end position="1921"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB73315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2059" mass="235017" checksum="813ACE77BCCBB9DB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK57</accession>
    <name>A0A401PK57_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0002569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01000650">
        <property type="protein sequence ID" value="GCB73485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK57"/>
    <dbReference type="STRING" id="75743.A0A401PK57"/>
    <dbReference type="OMA" id="ELFICFH"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000003">
        <property type="entry name" value="OTU domain-containing protein 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="150"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB73485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="296" mass="34175" checksum="4AD4538F6786212F" modified="2019-05-08" version="1">MEEIETEEEKLFKKHRKEKKELQAKIQAMKNAVAKNDKKRRKQLVEKVAKFEAELELRHEEELKQLTRSLDKPSTVESSTNEITNLELEIENEKTIEQSRISKAQKRREKKAAQDKEREERIAEAEIENLKGARHLENQKLAEILAKRQLQIKQIPSDGHCMYKAIEDQLKKQNSLLTLAELRIQAAEYMRSHVDDFLPFLSNSNTGDMYTPEEFEKYCDEVANTAAWGGQLELRALSHVLKMPVEVIQADSAPVTIGEEYGSKPVILVYMRHAYGLGEHYNSVEQLTDLPAEDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK76</accession>
    <name>A0A401PK76_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0002584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01000657">
        <property type="protein sequence ID" value="GCB73505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK76"/>
    <dbReference type="STRING" id="75743.A0A401PK76"/>
    <dbReference type="OMA" id="FTMGNGL"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB73505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="167" mass="18167" checksum="E43159FB345850DA" modified="2019-05-08" version="1">METRKKPRVYLDIAACGNMLGHVVIELRADVVPKTAENFRALCTGEKGFGYKGSICHRIIPEFMCQGGDFTKHDGTGGKSIYGEKFKDENFKLEHTGAGILSMANAGPNTNGSQFFICTAHTLWLNGKHVVFGKVIEGYEVVKKMEKLGSGEGKTSSTVSIINCGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKN2</accession>
    <name>A0A401PKN2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein THEM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000714">
        <property type="protein sequence ID" value="GCB73694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKN2"/>
    <dbReference type="OMA" id="YFIRCAF"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="17839" checksum="A33CDE07D16FC6DC" modified="2019-05-08" version="1" fragment="single">MWFVVALFSVLPFTFFDFWYFMRGILVFLVASLDAPVKDILKEQTVRSIVLLQDIDFLGHMNNSRYLRECDFARISLYIRNGMFHVTRKLKANMVLGAATIRYRRSLRLFEQFKIRSRILCWDEKAFYIEQEFISCRDSFVCATMLCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLP2</accession>
    <name>A0A401PLP2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000832">
        <property type="protein sequence ID" value="GCB74047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLP2"/>
    <dbReference type="STRING" id="75743.A0A401PLP2"/>
    <dbReference type="OrthoDB" id="9937592at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="229" mass="26186" checksum="7DFFA3CE04B76832" modified="2019-05-08" version="1">MPSSPEGMAKGMEESGIEAPPKPASPSKELQIQFPADTNSRWHTCGPERESKSNINTSLKVMPVEEQNTSVNSNESLLDYSSTKDESESLLKDQPKENNLKMSFSPWSKLLNMYSKMKKSPIPKFHSKENSQELLKEDGQRIQLIVYRCNESNPLVFSHFRTTDSVGFVEMEIKKMLDVQNEVRLWKKGLNDETSLLQRSDSTLKDAGILREQVLLLEEKDVHESRSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLU1</accession>
    <name>A0A401PLU1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000855">
        <property type="protein sequence ID" value="GCB74102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLU1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="79" mass="9526" checksum="EDAF155226BBBADC" modified="2019-05-08" version="1">MHTAQCFIILEMNETFSELFGTEMCKDCRRRERAPETDRQTDTHRERKNYTCVTSSFCHNKQDNRVYFSDWSCVKPHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMG2</accession>
    <name>A0A401PMG2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0003382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000910">
        <property type="protein sequence ID" value="GCB74293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMG2"/>
    <dbReference type="STRING" id="75743.A0A401PMG2"/>
    <dbReference type="OMA" id="WNSHELF"/>
    <dbReference type="OrthoDB" id="9946672at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07699">
        <property type="entry name" value="IgC1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000283">
        <property type="entry name" value="Immunoglobulin kappa constant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019049129" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="136"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB74293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="25493" checksum="1CC5C2A870E37BAB" modified="2019-05-08" version="1">MSNWIRVVIALVFCVVCLNAEITVNQPLSMSASIGSNVQISCTMSGQSLGSNTVSWYKQIPGNTPQLLVYYWSGSSIYRGPGISERYSGSVSGNTGTFTMSNAQSEDAADYYCAMWYSSLFFGKGTRLSVGNPQAPSAAVLPPSSDQITAKNTATLVCLVSGFNPGAAEIEWTVDGSVRGNGVETSRIQQEADNTFSVSSYLTLSASEWNSHELFSCLVKHEALANPLKRSISRSGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNE4</accession>
    <name>A0A401PNE4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001050">
        <property type="protein sequence ID" value="GCB74647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNE4"/>
    <dbReference type="STRING" id="75743.A0A401PNE4"/>
    <dbReference type="OMA" id="TECNAWS"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="222" mass="25252" checksum="918841D6227B3170" modified="2019-05-08" version="1">MLKVTAESLEECQMTRQSLWKNAQVHGKVPGRMHKFTAKSLEECSSTQQSPWKNARVLSKVPGRMLEFSAKTLEEFSRSLPSPWKNARVLGKDPGRMITVTAKTLEECSSSRQSPWKNARVLGKDPGRMLAVIAKSLEECSSSRQRPWKNARRHCKVPGRMHKFTTKFLEECTSSRQSSWKNAQDHGKVPGRMVEVTAKSLEECRKSRQNPWKNSRVQGTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQI2</accession>
    <name>A0A401PQI2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MCM3-like winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0019758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015045">
        <property type="protein sequence ID" value="GCB75384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQI2"/>
    <dbReference type="STRING" id="75743.A0A401PQI2"/>
    <dbReference type="OrthoDB" id="9950605at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM3-like winged helix" evidence="2">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="189" mass="21641" checksum="B442E248C1D57B1C" modified="2019-05-08" version="1">MSKTIDLQDSEAAIELVQFAYFKKVLEKGKKRHKEESDVETEEEEMSQEDGDSKKRRKAQTEDGKGRKRRRELKEGEQYDPYDFSDAEGETPDIPPRTPKTPEAEERMDTDDGAVKKPVLSDQRLKEFKAALLDAFKSAHAQSLGMQTLMASINKDNKEPFSDVEVQTALDKMQEDNQIMVSDHIIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQU7</accession>
    <name>A0A401PQU7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0015330</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01008650">
        <property type="protein sequence ID" value="GCB75490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQU7"/>
    <dbReference type="STRING" id="75743.A0A401PQU7"/>
    <dbReference type="OMA" id="CEVCATS"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15732">
        <property type="entry name" value="FYVE_MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14586">
        <property type="entry name" value="PTP-MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000073">
        <property type="entry name" value="myotubularin-related protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046352">
        <property type="entry name" value="MTMR3_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF66">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="16">
        <location>
            <begin position="155"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="1142"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1014"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="324"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="349"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="412"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB75490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1221" mass="137312" checksum="C330EBE92571C915" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQY3</accession>
    <name>A0A401PQY3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metallophosphoesterase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0019024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013778">
        <property type="protein sequence ID" value="GCB75539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQY3"/>
    <dbReference type="STRING" id="75743.A0A401PQY3"/>
    <dbReference type="OMA" id="SENCKGK"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF0">
        <property type="entry name" value="METALLOPHOSPHOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB75539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16985" checksum="0BA728804566F68F" modified="2019-05-08" version="1" fragment="single">HYPLYRVSDAECTGEDSASAEEKKLLFREKYDTLSLEASKKLLWWFHPRLVLSGHTHSACMVLHAEHLPEISIPSFNWRNRNNPSFLLASITATDFTLSKCFLPRESTIWAIYLTAAVVMANLILFHFNFWQWMMHYLINKHKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT15</accession>
    <name>A0A401PT15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008778">
        <property type="protein sequence ID" value="GCB76270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT15"/>
    <dbReference type="STRING" id="75743.A0A401PT15"/>
    <dbReference type="OrthoDB" id="6430345at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09567">
        <property type="entry name" value="SAM_kazrin_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09570">
        <property type="entry name" value="SAM_kazrin_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037614">
        <property type="entry name" value="Kazrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037615">
        <property type="entry name" value="Kazrin_SAM_rpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037616">
        <property type="entry name" value="Kazrin_SAM_rpt_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776:SF1">
        <property type="entry name" value="KAZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776">
        <property type="entry name" value="KAZRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="156"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="324" mass="36649" checksum="455BD6D7B797BF2C" modified="2019-05-08" version="1">MQASVCVSVQASVCVSVQTLVLLSLNDDDLELGLGVNSSMHRRKLRLAIEDYREAENGKGLSKASELDHHWVAKAWLNDVGLLQYSQAFHNHLVDGRVLNSLTKRDLEKYLNVSKKFHQISLLLAIELFRQWEFDREILHERRTWCENHNVDPLVWTNQRVIKWVREIDLKEYADNLLNSGIHGAVLVLEPTFNSEAMATALGIPSNKHIIRRHLFEELNLIVNPARHGLMQESERLGQLCYAQQGSLGHNHTGENVLGDPEDETSRKYKAGRGPMESMKAFGGKDLGFHETHSPRPRGDSEETLSRPACSSLQTFTGIDVTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTR6</accession>
    <name>A0A401PTR6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intraflagellar transport protein 25 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heat shock protein beta-11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Placental protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0015502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27. Interacts with IFT88.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IFT25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008819">
        <property type="protein sequence ID" value="GCB76502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTR6"/>
    <dbReference type="STRING" id="75743.A0A401PTR6"/>
    <dbReference type="OMA" id="MWTRNAK"/>
    <dbReference type="OrthoDB" id="271080at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000081">
        <property type="entry name" value="Intraflagellar transport protein 25 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033558">
        <property type="entry name" value="IFT25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB76502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="15657" checksum="FBCB5B74CACC92C8" modified="2019-05-08" version="1">MKQDFGLTVAGTQVVLAASGDEKHPPENIIDGNSETFWITTGMFPQEFILSFANLIKISSVKIHCYNVHSLSIEKSVARDPIDFEPLTNSELERSEEQLQMEEFTQVGTSATHLRFLIKSGFDHFVSIHKVTVEGTEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXM9</accession>
    <name>A0A401PXM9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0015725</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cell membrane</location>
            <topology evidence="1 17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009059">
        <property type="protein sequence ID" value="GCB77858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXM9"/>
    <dbReference type="STRING" id="75743.A0A401PXM9"/>
    <dbReference type="OMA" id="CVMLFTY"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043149">
        <property type="term" value="P:stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000075">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000258">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000021">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF26">
        <property type="entry name" value="INTEGRIN BETA-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PSI" evidence="19">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="18">
        <location>
            <begin position="22"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB77858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="575" mass="64037" checksum="D2AB6766E93BE195" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXV6</accession>
    <name>A0A401PXV6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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        </lineage>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="249" mass="27602" checksum="1590C449E35C7B0B" modified="2019-05-08" version="1" fragment="single">ADAGVELSAPLAEPSGEDDQKETQEPSELAKQEVLVQYLKDALSFASKIEGAIEIVSKFLSSKNPSVVQETIQFFVTISEFGISQALVGMREMLPLVWSKEAGVKEAVTDAYRRLYLNEESSKPQALVQNLTALIFDSNVDSIKCLEQLVSEFVQKNEIKPAVIQLLWERLTEKVATTPSERRAAVILLGMAARGEPEIVGSNLETLYVVGLGPRVREQQDYQLARDTCLAISKLSQGKKVSRRQYQNL</sequence>
</entry>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Galeoidea</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017023">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    <proteinExistence type="predicted"/>
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            <end position="85"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17141" checksum="1C7889CE76C6E0AC" modified="2019-05-08" version="1" fragment="single">TSIFTPIKGSVTNVRINSTLTTQEVIALLLQKFKIENDPNDFALYVVHASEEKIKLQNTAFPLWERFLHGPSRNIVKIFLMDKGAEEISIDVAQYIKFELTVLKAILQKLTEEEQKHIGNAQLRYKVEKRSLIRQLQRRMMVRAETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ55</accession>
    <name>A0A401PZ55_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011778">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB78424.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="89920" checksum="3FE2DD8F34E05313" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401PZU9_SCYTO</name>
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        <recommendedName>
            <fullName evidence="2">Chaperone DnaJ C-terminal domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="3 4">
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011822">
        <property type="protein sequence ID" value="GCB78646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PZU9"/>
    <dbReference type="OMA" id="FFCREEN"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF519">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chaperone DnaJ C-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16496" checksum="ED3545A5B9D6E5C6" modified="2019-05-08" version="1" fragment="single">EISLGFGGPQGRGAKKQDPHIEKDLYLSLEDLFHGCLKKIKISRRTMNEDGHTSSIKDKILTIQVKQGWKLGTKITFPKEGDQGPNNIPSDIIFVLKEKPHKFFCREENDLIFCAPISLAKALTGHTVQIETLDGRFLSIPINDIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0L1</accession>
    <name>A0A401Q0L1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0015904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009261">
        <property type="protein sequence ID" value="GCB78922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0L1"/>
    <dbReference type="STRING" id="75743.A0A401Q0L1"/>
    <dbReference type="OMA" id="MESELCQ"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000902">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000309">
        <property type="entry name" value="zinc finger X-chromosomal protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF15">
        <property type="entry name" value="REDUCED EXPRESSION 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB78922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="313" mass="35082" checksum="A89640462ABC60FC" modified="2019-05-08" version="1">MDTRTMGKPWKCGDCGKGFRSPSELETHRRSHTGERPFTCSQCGKGFTNSSDLLTHQRVHSGERPFTCSECGKGFTNSSNLLRHRRVHSGERPFTCSVCGKGFRDSSILLAHQRVHSGESPFTCSVCGKEFTQSSNLLRHRRVHSGERPFTCSVCGKGFRDSSDLLAHQRVHTGERPFICFTCGKGFGDSSTLQTHQRVHTGEKPFTCSICGKGFTQLSNLLRHQQVRSRERPFTCSTCKKGFSDLSTLLTHQRVHTGEKPFTCSVCGKGFSRSSNLLTHQRVHTGEKPFTCSDCGKEFIQSSHLLRHQRVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1V7</accession>
    <name>A0A401Q1V7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0020198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015983">
        <property type="protein sequence ID" value="GCB79348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1V7"/>
    <dbReference type="STRING" id="75743.A0A401Q1V7"/>
    <dbReference type="OrthoDB" id="8783244at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF98">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB79348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7890" checksum="955208A825C0FA46" modified="2019-05-08" version="1" fragment="single">MLWFAFVNGFSGQILFERWCIGLYNVIFTALPPFALGIFERTCSQENMLRFPQLYRITQNADCFNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2D4</accession>
    <name>A0A401Q2D4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017327">
        <property type="protein sequence ID" value="GCB79483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2D4"/>
    <dbReference type="STRING" id="75743.A0A401Q2D4"/>
    <dbReference type="OMA" id="HEMSTCP"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF2">
        <property type="entry name" value="AMP DEAMINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="237" mass="27411" checksum="BD3DD2A12BFB436F" modified="2019-05-08" version="1" fragment="single">KKSLRLIRSHSLSLQIPTSDVTFSVDSPSLTPQTPIQNVPLFGIQLPYDVPEFQRVTITGDYCAGITVEDYEHAARGLIKALFIRKKYMRLAYQLFPRTTGQYLQSVGNDLWLEEDEVLPDFHPPPRDGEDPYDLSGAPDNLEYVARMKEGIIFVYENKEMLEQDEPKSLPYPDLQTFTLDLNHVLALIADGPTKTYCHRRLNFLGSKFYLHEMLNEMAELRELKCVPHRDFYNVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2J5</accession>
    <name>A0A401Q2J5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-PDSW</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase PDSW subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB10 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012022">
        <property type="protein sequence ID" value="GCB79543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2J5"/>
    <dbReference type="STRING" id="75743.A0A401Q2J5"/>
    <dbReference type="OMA" id="KSYRQNC"/>
    <dbReference type="OrthoDB" id="6017729at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019377">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10249">
        <property type="entry name" value="NDUFB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB79543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="189" mass="22375" checksum="8D1EAE983A34D3C8" modified="2019-05-08" version="1">MRMRSAHCPPPLVGAMPDDWDKDIYQQPASRTPAVDKKTGLPNPAVIVGKLFYYSVDLPVTTFREWVERQREKNKFYYYHQQFRRVPDITDCQFGDYLCYYEAEMQWRRDYKVDQEIMGILQERLRACQQREGNSYIQNCAKELEQFKLGAKGYQSRYGDLGAYGSARRCLMKQKHRMIEEREKAASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2Z6</accession>
    <name>A0A401Q2Z6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014762">
        <property type="protein sequence ID" value="GCB79807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2Z6"/>
    <dbReference type="STRING" id="75743.A0A401Q2Z6"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="71" mass="7952" checksum="93E7916041D85F0F" modified="2019-05-08" version="1">MTMKQEGYMLPGNMSAQTSLLDSAIDPQFSEGMTVMTQRMEGGTSITQQVTRTMMTSGTITKQMERKFYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5A9</accession>
    <name>A0A401Q5A9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009713">
        <property type="protein sequence ID" value="GCB80569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5A9"/>
    <dbReference type="STRING" id="75743.A0A401Q5A9"/>
    <dbReference type="OMA" id="CEAIHNS"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22288">
        <property type="entry name" value="CWC27_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="142" mass="16980" checksum="E230E3AB9F0F623B" modified="2019-05-08" version="1">MDYFKEHRLIEGYHCEAIHNSAPNSAVAEYLIERKKYEELRRQKPKNGSSREEQTLALLDRFKVKLTKAISETPEEEPVQTEGEDDQGWLSHVLQFEEQTRKVKDANIQDEDTFEIHDPRNPVNKRRREESKKIMKEKKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5R3</accession>
    <name>A0A401Q5R3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009808">
        <property type="protein sequence ID" value="GCB80687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5R3"/>
    <dbReference type="STRING" id="75743.A0A401Q5R3"/>
    <dbReference type="OMA" id="QTHIFRK"/>
    <dbReference type="OrthoDB" id="8936120at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF235">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="184"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="304" mass="33989" checksum="12167A60D61DAB1E" modified="2019-05-08" version="1" fragment="single">GVAQRVNTQGSHTLQHLFIHKVTGVPRFSMAGMLDDLQTQYYDSSLGTTEPRQQWMADSFADDYWSKQTKIAETLHHLLSSNLDAYLKRFNVQYIQGLWSCTQQNNMSTIGLVKIYSVYGEIQCQMATEHCSGTGIIKDFLKDIFQKIRITNVDLVQSLNDSCVQNMQRTLQAGKAALERKVAPEVLVFNDISSDEVPMTLLCLVTPFYPRAINATWLQNGEPVPDDLTMTVVPNHDGTYRMEILVDLEDNDPRGYTCQAQHSSLSKTLRVEAGKLPENDRAQRVAIRHSCASSLALWGGAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5T2</accession>
    <name>A0A401Q5T2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0023224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01027373">
        <property type="protein sequence ID" value="GCB80736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5T2"/>
    <dbReference type="STRING" id="75743.A0A401Q5T2"/>
    <dbReference type="OMA" id="GHCCSRL"/>
    <dbReference type="OrthoDB" id="264520at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF299">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB80736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="630" mass="69433" checksum="95EF3332E1BCBA2E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6M7</accession>
    <name>A0A401Q6M7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TSP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027735">
        <property type="protein sequence ID" value="GCB81028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        <property type="entry name" value="TSP_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSP C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="14328" checksum="F0E9B87330933B8E" modified="2019-05-08" version="1" fragment="single">YTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGLQLKAVKSRTGPGEHLRNALWNTGTTHDQVTLLWKDPRDVGWKDKTSYRWQLMHRPQVGYIR</sequence>
</entry>
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    <name>A0A401Q7F4_SCYTO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000288216">
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    </dbReference>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Myosin, subunit A"/>
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    </dbReference>
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        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF15">
        <property type="entry name" value="RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB81324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="202" mass="23835" checksum="3C2CAF5F73022163" modified="2019-05-08" version="1" fragment="single">STISGVTAAYNREQLWVANETLITKLQARCRGYLVRRGYSDRLNFLKKQQPAILTIQSNWRGHKQAQAYKKRLQYLKDNADSAVKIQSLVRMHQAKKKYQDRIKYFKDHEPDIVKIQAFIRANKARDDYKTLINAEQPPMAVVRKFVHLLDQSDQDFQEEVEMMRLREEVVTRIRSNQQLENDLNMMDIKIGLLVKNKITLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7M8</accession>
    <name>A0A401Q7M8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025377">
        <property type="protein sequence ID" value="GCB81379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401Q7M8"/>
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    <dbReference type="Proteomes" id="UP000288216">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
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    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="14806" checksum="C24DA0AFDD3C1A61" modified="2019-05-08" version="1" fragment="single">ARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRVIRGKTDYGLMIFADKRFARADKRGKLPRWIQEHITDGNLNLTVDEAVQISKHFLRHMAQPFRQEDQLGLSLLSLDQLESEEILQKIQQISHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q893</accession>
    <name>A0A401Q893_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RETREG1-3/ARL6IP-like N-terminal reticulon-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024218">
        <property type="protein sequence ID" value="GCB81581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q893"/>
    <dbReference type="STRING" id="75743.A0A401Q893"/>
    <dbReference type="OMA" id="GWWKFHN"/>
    <dbReference type="OrthoDB" id="6416122at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006613">
        <property type="term" value="P:cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22559">
        <property type="entry name" value="Arl6IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052114">
        <property type="entry name" value="ER_autophagy_membrane_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057282">
        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952:SF0">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952">
        <property type="entry name" value="ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="6">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="132" mass="15353" checksum="FFDE10DCE273199C" modified="2019-05-08" version="1" fragment="single">ASETAQLEEHLEGWGEVMLAADRILRWEKPWFPAIMMLVVSVVFLLIYWLDPSVLTGVSCAIMMICLADYLVPTIASKMFGSNKWTTEQQQRFHEICSNLVKTQRRIVGWWRRLFALKEEKPKMVRINPVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8X4</accession>
    <name>A0A401Q8X4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S100/CaBP-9k-type calcium binding subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023050">
        <property type="protein sequence ID" value="GCB81816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8X4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S100/CaBP-9k-type calcium binding subdomain" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16620" checksum="C239A14E514C1F72" modified="2019-05-08" version="1" fragment="single">VARSPLVANGSEGPSQYGWGTEGSGGYKWLAQTARHSHRSPQTNFLSQIICGCTNVRMGSLRGHVNGINDIFLKYSREDNDHDKLNRSELRNLFKAEMPELKAGELDSLVDMIMEMEAADDKQVDRTEFFLIASCLILGKAPKQCCKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9H2</accession>
    <name>A0A401Q9H2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WASH complex subunit 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019231">
        <property type="protein sequence ID" value="GCB82020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9H2"/>
    <dbReference type="STRING" id="75743.A0A401Q9H2"/>
    <dbReference type="OMA" id="AMAWNVE"/>
    <dbReference type="OrthoDB" id="10261210at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028283">
        <property type="entry name" value="WASH-7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027307">
        <property type="entry name" value="WASH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14746">
        <property type="entry name" value="WASH-7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH complex subunit 7 C-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="109" mass="12987" checksum="C185A790991E77DC" modified="2019-05-08" version="1">MIAGVAYILKLLDQYQEFDSLQWFQSVREKYLREKNAVVKQQNVQSTNQDEKLMQTMNLTQKRLDIYLQEFELLYFSLSSARIFFRGDQSAAEESQERKEKEGKYSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAY1</accession>
    <name>A0A401QAY1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0022346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022189">
        <property type="protein sequence ID" value="GCB82522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAY1"/>
    <dbReference type="STRING" id="75743.A0A401QAY1"/>
    <dbReference type="OrthoDB" id="10003276at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF41">
        <property type="entry name" value="DBH-LIKE MONOOXYGENASE PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="5">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB82522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13791" checksum="450A3F412D864B9C" modified="2019-05-08" version="1" fragment="single">TLIYPDEAGFPLGGLEDKAYYMLQIHYDNPTQQAGVFDRSGFKLHLTTDLRKFDIGILWTGIQVAQFLIIPPKASSFKNYGYCDTSPVNKEEGKKYTDMQIFGSILHTHLTGSKIRILQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCX8</accession>
    <name>A0A401QCX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030648">
        <property type="protein sequence ID" value="GCB83239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCX8"/>
    <dbReference type="STRING" id="75743.A0A401QCX8"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 2D-like PUA RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="eIF2D winged helix" evidence="2">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24753" checksum="60EFDBEE99E4B27E" modified="2019-05-08" version="1" fragment="single">LMLPGVVVPPSGLPEVQQGDLCAVNLVENRAPVAVGLVTIPTAEMIAADMKGKGVITLHTYLDELWAFGEKTSPPVIPHVYCESGETGHQTEEEEDEENEEGTDDIKHVTAELDSIENDTADMGSLGFNVENESEHASSATGQTHDSKAHGSEIVDLKEIIKDTGNDQDTGNDQDTGNDQDSTEITGTVQEQMDELLLQCSLHALKFKVKKADLPLLTSTFLKVHVYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDV7</accession>
    <name>A0A401QDV7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0024151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01040222">
        <property type="protein sequence ID" value="GCB83598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDV7"/>
    <dbReference type="STRING" id="75743.A0A401QDV7"/>
    <dbReference type="OMA" id="NIYPENK"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB83598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="14026" checksum="434505D05FF61494" modified="2019-05-08" version="1" fragment="single">LAYVDSQGEHINLVQMTFLKLLSASARQNFTYNCQHSVGWYDAASDSYDKALRFLGSNDEEMSHDNNPYIKAIYDGCTLSKGLEKTVLEINTPKVDQVPIMDLLVSDFGSSNQRFGFEVGAVCFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEM2</accession>
    <name>A0A401QEM2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C-beta C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01040696">
        <property type="protein sequence ID" value="GCB83767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEM2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase C-beta C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="65" mass="7805" checksum="7D6D9EBE6069AFCC" modified="2019-05-08" version="1" fragment="single">LEPLTIDELKTHKAFVKVQKKQEKELKELERKCQKKKDVIQKYSSSFSELRKKSFSLSKGHKKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF82</accession>
    <name>A0A401QF82_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01050379">
        <property type="protein sequence ID" value="GCB84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QF82"/>
    <dbReference type="OMA" id="QRDTETQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="376" mass="43500" checksum="57EA6FDC0F204257" modified="2019-05-08" version="1" fragment="single">TETETQRDTETQTEVQRGTDRDRGTDRDTDRDIDTDRGRDRDTDRDTDRDTHTDTDRGRDADRDTNTETDRHRDTDRDSGSDTDRDTDRDTETDRDRERDTARDTDRNTDRDTDRDTDRDTDRDTYRDTGTTGTQTQRERYRHRQRGRQIHRHRQRQNHRQRHRHTKTQTQTETQTETQAETQAETQTQTGTQTQTGTQADTETQNSTQTQTETQTETATETATETATQTDTDGGTDRDTNRDIDTDRDTDRDTDRDRDTGTDRDTGTDIDRETDRNSDRDSGTDRDIDTDRDRDTGTDIDRDANRDRDTGTDRDTGTDRDTGTDSDRDTGTDTDTDTDRETDRNTDRERIGQTQAETQAEIYHSALPGETVGGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFB1</accession>
    <name>A0A401QFB1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">scyTo_0024811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
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        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB84032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="101" mass="11223" checksum="28695146134E038F" modified="2019-05-08" version="1" fragment="single">MQCDSRRSALLCTVCPCHQAARCRQSCSPCLACWVRRDPSSGHFLHVALADVEKTATPRKLFLKTASLDAMSESLKKCYIYLNQTSRSFAAVIQALDGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFP9</accession>
    <name>A0A401QFP9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
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        <lineage>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01050930">
        <property type="protein sequence ID" value="GCB84183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFP9"/>
    <dbReference type="STRING" id="75743.A0A401QFP9"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="35" mass="4213" checksum="7200F5F6F51B4D41" modified="2019-05-08" version="1" fragment="single">MEQYANNLEELVEDRTQAYLEEKRKAEALLYQILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG48</accession>
    <name>A0A401QG48_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01065721">
        <property type="protein sequence ID" value="GCB84323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG48"/>
    <dbReference type="STRING" id="75743.A0A401QG48"/>
    <dbReference type="OMA" id="VYGICAQ"/>
    <dbReference type="OrthoDB" id="10070383at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="59" mass="7184" checksum="0BDEC5051514145D" modified="2019-05-08" version="1" fragment="single">MIDKQISDWRQKCEEIQTELESSQKECRQYATELFKLKTSYEELIEQLDSLKRENKTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG82</accession>
    <name>A0A401QG82_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01060778">
        <property type="protein sequence ID" value="GCB84352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG82"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8925" checksum="CC5019F14FA59E3B" modified="2019-05-08" version="1" fragment="single">MFYFFDLVLVCLLQDFERKTKALRESCIELSKEITQRKREIKTTKEEVENKMDDVKNMQIELEKKLEDEEHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGU0</accession>
    <name>A0A401QGU0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Magnesium transporter MgtE intracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01088132">
        <property type="protein sequence ID" value="GCB84648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGU0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158791">
        <property type="entry name" value="MgtE N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Magnesium transporter MgtE intracellular" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="17242" checksum="E8DF76AE49A2C553" modified="2019-05-08" version="1">MQVLMWCEQDLVPNQASEQQQASVLNQASEQQQASVLNQASEQQQASVLNQASEQQQASVLEQASVLEQASVLEQASVLAQASMLAQAPVLALVCTAQASMLAQASVLALVCWEQASARFHKLCRLLQTCPWQGPERQGQRGGPGFCGQAGRRWAGHWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH58</accession>
    <name>A0A401QH58_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01084223">
        <property type="protein sequence ID" value="GCB84647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH58"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="217" mass="23875" checksum="F653DE7805E8540C" modified="2019-05-08" version="1">MRGDSSSLVEPRSDQTLPEEEGHLLEEELLDAMEDGVSSAGTAEEVNPSDERMRTEESIRLVEGDGNVAEEHHPAAQRNPNPRPGEEFIRIRDHQLQAAEESPGLGPGPGLGPGPGLETVGLTSRASEPADKGLDAVQERGRPAGQSDHLTGPDMYKVNPFKQDFRSLRWLNHFDRSQLKALQKALKREFALIQGPPGTGGWLRIIRLSLRVKRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIK8</accession>
    <name>A0A401QIK8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01135777">
        <property type="protein sequence ID" value="GCB85197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIK8"/>
    <dbReference type="STRING" id="75743.A0A401QIK8"/>
    <dbReference type="OrthoDB" id="10009851at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042799">
        <property type="entry name" value="TLNRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47133">
        <property type="entry name" value="TALIN ROD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47133:SF1">
        <property type="entry name" value="TALIN ROD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="348" mass="37322" checksum="7AF69B3BCB16D20B" modified="2019-05-08" version="1">MDCGGWEGALDPDSPVAYNESRLVYISDSCKRKIQHVADQLLSCDARPVESNSLSSCGESFEKCRDTIIARTKGLAILVHELQYLVPVGKDEEVGRGLLELCNLVVALVECSAHAGYLAALEVPGARPARPGPVEPYKVSVLEQEVEQHCSCLGSLPLGQLSPARLADVSQGVGRALRGLTDCCGPAGEAGRDALAREQLRLGLRGASCCARALLACVRELRAAPSERARARCVVFSRPLLQSVHALVGLATEPQFLGRPAHLPAEGRSVHANILEAARRVVSSCLLFVQWIRDVAQLSSSGARVPTFREQVKSLTGAVSDSCNLLSQVLRDNDTLNLFNPWNGNSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ50</accession>
    <name>A0A401QJ50_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01149224">
        <property type="protein sequence ID" value="GCB85402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ50"/>
    <dbReference type="STRING" id="75743.A0A401QJ50"/>
    <dbReference type="OMA" id="FEAPLMD"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16966" checksum="6066D8187EA7CC1B" modified="2019-05-08" version="1" fragment="single">FDEFDDPVFAEFDDPVFTEFDNPVIPEFDDPIFDEFDDRVFAEFAGLVFAEFDDRVFTEFDNPVIPQFDDPIFDEFDDPVFAEFDDPVFAEFDDRVFTEFDDPVIPEFDDRVFAGFEAPLMDVSDGLAVERFTNLAPGATASPGSFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ90</accession>
    <name>A0A401QJ90_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01167516">
        <property type="protein sequence ID" value="GCB85435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ90"/>
    <dbReference type="STRING" id="75743.A0A401QJ90"/>
    <dbReference type="OMA" id="KISCHQD"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="15908" checksum="82CA1109F8C035E9" modified="2019-05-08" version="1" fragment="single">DTDAQDTDAQDTDTQDTDAQDTDTQDTDAQDTDTQDTDIQDTDTHDTDAQYADAQGTDAQDTDIQDTDAQDTDAQDTDAQGTDAQDTDAQDIDIQDTDAQDTDAHDTDAQDSDGQRTDAQDTDAQDTDAQDTDPQDTDIQDTDTQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJT1</accession>
    <name>A0A401QJT1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01178531">
        <property type="protein sequence ID" value="GCB85593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJT1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="11557" checksum="1544A3C7DD951B74" modified="2019-05-08" version="1" fragment="single">MTDDALLLIEDPLILIEEPLIFIEDALLIEASLLLIEYSLLLTDDALILIEDPLLLTDNPLFLIENALLLIEDLVNVIEVHLILIEDAFLLIEDPLIFIEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMI1</accession>
    <name>A0A401QMI1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01324151">
        <property type="protein sequence ID" value="GCB86637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMI1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12234" checksum="30B46CC86C62D5D5" modified="2019-05-08" version="1">MSWSETCRGHKRVMVGNVSGSAPCRDQKLYSGRKRVVVGSVSWSETCRGRKRVLVGNLPWSEPCPGRNRVVVGTASWSEPPPGQNRLLVGNSSWTETRPGRKLVLVGTVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPS5</accession>
    <name>A0A401QPS5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0028004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01448976">
        <property type="protein sequence ID" value="GCB87328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPS5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="142" mass="15880" checksum="31F1789A7417C2D4" modified="2019-05-08" version="1" fragment="single">ETDSNISKTEREEDPETDSHISKSGREQDPVSDSNTSKSGREEDLETESNMLKSGREEDPKTDCNISKTGREEDPKTDCNISKTVREEDPKTDCNISKSGREEDPGTDSNISKSGREGDSETYSYISKTEREEDPETNSNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NFX9</accession>
    <name>A0A401NFX9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004869">
        <property type="protein sequence ID" value="GCB59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NFX9"/>
    <dbReference type="STRING" id="75743.A0A401NFX9"/>
    <dbReference type="OMA" id="HHQMLVL"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="2">
        <location>
            <begin position="144"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32384" checksum="75CFED1F8C8F726B" modified="2019-05-08" version="1">MRLSLAALSGRAVRITGIRSQELNPGLRDFEASFIRLMDKVTNGSRIEINETGTTLYYQPGILLGGKIEHDCHPQRSIGYYLEALLCLAPFMKRPLKAILKGVTNDQTDPSVDTLKVTALPLMQRFGVDGEGLELKVIRRGMAPGGGDIYIYTDHMKGANSGKSPGFGLSLVAETINGTFLSAELASNPQGQGSPVLPEDLGQNCAKLLLEEVYRGGCVDSINQSLALLYMALGQQDVSKVQIGPLSPYTIEFLRHLKSFFQIVFKIEAQPMEEQKGGDKVLMTCIGVGFSNISKTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGP4</accession>
    <name>A0A401NGP4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Nuclear factor of activated T-cells 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">T-cell transcription factor NFAT5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0012677</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer when bound to DNA, completely encircles its DNA target. Interacts with CIDEC; this interaction is direct and retains NFAT5 in the cytoplasm. Does not bind with Fos and Jun transcription factors. Interacts with DDX5 and DDX17; this interaction leads to DDX5/DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX5/DDX17-enhanced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006193">
        <property type="protein sequence ID" value="GCB60090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NGP4"/>
    <dbReference type="OMA" id="PYQNQVI"/>
    <dbReference type="OrthoDB" id="5346094at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07882">
        <property type="entry name" value="RHD-n_TonEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000174">
        <property type="entry name" value="Nuclear factor of activated T-cells 5, tonicity-responsive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000002">
        <property type="entry name" value="Nuclear factor of activated T-cells 5, tonicity-responsive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008366">
        <property type="entry name" value="NFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015646">
        <property type="entry name" value="NFAT5_RHD_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533">
        <property type="entry name" value="NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533:SF10">
        <property type="entry name" value="NUCLEAR FACTOR OF ACTIVATED T-CELLS 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01789">
        <property type="entry name" value="NUCFACTORATC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RHD" evidence="22">
        <location>
            <begin position="178"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="648"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1063"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1115"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1162"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1233"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1118"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1175"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1234"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1251"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00072227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB60090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1455" mass="158582" checksum="697C6BE93DE15373" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHE7</accession>
    <name>A0A401NHE7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc finger FYVE domain-containing protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0012715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006226">
        <property type="protein sequence ID" value="GCB60293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHE7"/>
    <dbReference type="STRING" id="75743.A0A401NHE7"/>
    <dbReference type="OMA" id="ENERCEF"/>
    <dbReference type="OrthoDB" id="1936617at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHY5</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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            <end position="426"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1568" mass="172782" checksum="C75AC50770FB2686" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI43</accession>
    <name>A0A401NI43_SCYTO</name>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
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    <organism evidence="14 15">
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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        </lineage>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
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            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01269">
        <property type="entry name" value="PTB_TBC1D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000003">
        <property type="entry name" value="Putative TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2750:FF:000002">
        <property type="entry name" value="TBC1 domain family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000076">
        <property type="entry name" value="TBC1 domain family member 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021785">
        <property type="entry name" value="DUF3350"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF18">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11830">
        <property type="entry name" value="DUF3350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PID" evidence="12">
        <location>
            <begin position="157"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="13">
        <location>
            <begin position="687"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="934"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB60539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117921" checksum="2356CC8DC4EDCD92" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIB2</accession>
    <name>A0A401NIB2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0014199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007536">
        <property type="protein sequence ID" value="GCB60616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIB2"/>
    <dbReference type="STRING" id="75743.A0A401NIB2"/>
    <dbReference type="OMA" id="NRSCSQQ"/>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000176">
        <property type="entry name" value="Intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="8">
        <location>
            <begin position="122"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="7">
        <location>
            <begin position="230"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="396" mass="45253" checksum="EFBA4BE84D1784B9" modified="2019-05-08" version="1" fragment="single">KRFASGSTDKSIIIWTSKLEGILKYTHNDSIQCIAYNPVTHQLASCSSSDFGLWSPEQKSVSKHKVNSKITCCSWTNDGQYLAISLFNGVVSIRSKSGEEKVRIERPGAVPIWSICWNPSKDEHTDILSVADWGQRLSFYQLSGKQIGKDRALNFDPCCVSYFTKGEYIVMGGSDKQVSLYTKDGVRLGSIGEQQSWVWTCRVKPDSNYVVVGCQDGTIAFYQIIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIRCRELVKKIAIYKNRLAIQLPEKILIYELFSEDNTDMHYRVKEKIAKKFECNLLVVCSQHLILCLEKRLQCLSFSGVKEREWLMESLIRYIKVIGGPSGREGLLVGLKNGQMLHRLETDYVICLLKRCCRGKIMKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJM1</accession>
    <name>A0A401NJM1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006344">
        <property type="protein sequence ID" value="GCB61076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJM1"/>
    <dbReference type="STRING" id="75743.A0A401NJM1"/>
    <dbReference type="OMA" id="ETHIRNC"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="109" mass="12312" checksum="9A6E381F072CCF54" modified="2019-05-08" version="1">MGGELYNCKDPAVWRSVFTLYSDVVEEKTTTSKGRKAGKLAALDKWYQEELPRAVSGRTEKYLTHAELVQLMEWKLTISETHIRNCAKAIEHVTIPGVCSLESILVLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJT4</accession>
    <name>A0A401NJT4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rho-related GTP-binding protein RhoJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0014283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007606">
        <property type="protein sequence ID" value="GCB61122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJT4"/>
    <dbReference type="STRING" id="75743.A0A401NJT4"/>
    <dbReference type="OMA" id="RNTFPTG"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000438">
        <property type="entry name" value="Rho-related GTP-binding protein RhoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB61122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24178" checksum="B77B41ECA6D623E4" modified="2019-05-08" version="1">MPGVAKEQQRPRPPPRQQQRDMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVTITVGGKQHLLGLYDTAGQEDYNQLRPFSYPNTDVFLICFSVVNPASYHNVKEEWVSELKACMPHVPYVLIGTQIDLRDDPKTLARLIHMKEKPITYEQGVKLAKEIGAQCYLECSALTQKGLKTVFDEAILTVFHPKKRKRGCAKCRVCCAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLB7</accession>
    <name>A0A401NLB7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001197">
        <property type="protein sequence ID" value="GCB61668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLB7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="213" mass="23904" checksum="CC10998A1BB2F460" modified="2019-05-08" version="1">MMPSNTNTNPALEEGVDTQMNDEQPEKNRNKEKRRGRPGRKRKQTMVFSFLWHRASCVQDNRVYMRPNQQSLKGPLEAATIKVDINEASSEMVATPKCQSSQESSSQVHNGEVESNQQDIGNSQQFGERSVPENGDRAKSVPEAQNVKGQESNEESTSLDGEAEIDLEMENGCYTPKDGQDSEKGENEKVPSTLRKKYKKRQLEAAEKGLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLD1</accession>
    <name>A0A401NLD1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007683">
        <property type="protein sequence ID" value="GCB61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLD1"/>
    <dbReference type="STRING" id="75743.A0A401NLD1"/>
    <dbReference type="OMA" id="KKFQQVH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36963">
        <property type="entry name" value="HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36963:SF2">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="568" mass="52862" checksum="A7648E8026ECCF79" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM75</accession>
    <name>A0A401NM75_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cerebellar degeneration-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006472">
        <property type="protein sequence ID" value="GCB61952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM75"/>
    <dbReference type="OMA" id="GCRARQK"/>
    <dbReference type="OrthoDB" id="10059415at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026079">
        <property type="entry name" value="CDR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232">
        <property type="entry name" value="CENTROCORTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232:SF1">
        <property type="entry name" value="CEREBELLAR DEGENERATION-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB61952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="53528" checksum="60C7898852825750" modified="2019-05-08" version="1">MLTDSIIEDFELREEEPWYQQQQNMEHDLHLAAELGKTLLDRNTELEEALQQMYGTNQEQLQEIEYLTKQIELLRQMNEQHAKVYEQLDVTARELEVTNQKLVMESKASQNKIISLAETIDGLQSHVDELQRQLEELKDGSRKEGTEQRRAMHSLPCLKELYDLRKYFVYDHLFAAEITSDEAQVSPLEDENERLKKNMSMLQAQLTLERQRREGMEQEYSLLLRENGELEKSLSDLDDYKQSIQELESKVVELRQRSQEPADFVSVVDNLLPESFLFSGKDSSDLVHFSGIKLCVNGVGSQTEHGPPNLSETLLKNSSDEDPVRGHEQTCIRRAEAVRQRGISLLNEVDEQYIALQMKYNELLSRCHRPEDTLSHKAVQTSRRISQDQSGKAAQCEQQTSANEELLRSEPAACTAPLPIVELASSFSNTQPEYKVLFKEIFSCIRKTKAEINENRSKYKSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM91</accession>
    <name>A0A401NM91_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0007143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002536">
        <property type="protein sequence ID" value="GCB61996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM91"/>
    <dbReference type="STRING" id="75743.A0A401NM91"/>
    <dbReference type="OMA" id="LLEEAXK"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000151">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000010">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF4">
        <property type="entry name" value="NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="123"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="335"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB61996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="63522" checksum="E190584E202CC819" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMC8</accession>
    <name>A0A401NMC8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Voltage-dependent calcium channel alpha-2/delta subunit conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007738">
        <property type="protein sequence ID" value="GCB62033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMC8"/>
    <dbReference type="STRING" id="75743.A0A401NMC8"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF25">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-2/delta subunit conserved region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="153" mass="17632" checksum="4FBB72A6CA488718" modified="2019-05-08" version="1">MKLEFFQKKFWTASRQCASLDGRCTISCDDEIINCYLIDNNGFILVSENFDETGTFFGEVEGAVMNKLLMMGSFKRITLYDYQAMCRATVDNSDSAHSLLDPYYVFFAAIKWIMTELILFLVEFNLCSWWNSDFTVKELVKAGLELMIAELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMD5</accession>
    <name>A0A401NMD5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0009442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003854">
        <property type="protein sequence ID" value="GCB62009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NMD5"/>
    <dbReference type="OMA" id="CSIRINA"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000262">
        <property type="entry name" value="HEAT repeat-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF2">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1309" mass="141172" checksum="DECDD09DBD8A6A5B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQH6</accession>
    <name>A0A401NQH6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001290">
        <property type="protein sequence ID" value="GCB63130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQH6"/>
    <dbReference type="STRING" id="75743.A0A401NQH6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="14365" checksum="F05E9A467AB596F1" modified="2019-05-08" version="1">MVLQVSKILLYQKVNRGRFWDGYDSLMCYMNFRPGFKTEAAVRYRAPLLWSALIPLGIGGNTAYILLGMAEDAKLNTRKVLTLSAMYTGPDEIPKIIEEAVGWKGKEFWDEMELFSLILPQRPMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQM4</accession>
    <name>A0A401NQM4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0013165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006622">
        <property type="protein sequence ID" value="GCB63188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQM4"/>
    <dbReference type="STRING" id="75743.A0A401NQM4"/>
    <dbReference type="OMA" id="CRDESIQ"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13226">
        <property type="entry name" value="PH-GRAM-like_Eap45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000203">
        <property type="entry name" value="Vacuolar protein sorting 36 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000241">
        <property type="entry name" value="Vacuolar protein sorting 36 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000170">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB63188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="386" mass="43841" checksum="3FFCFB239FB1AF08" modified="2019-05-08" version="1">MDRFVWASGLLEINETLVIQQRGVRLYDGDEKTKFDLGTVVLSTHRLLWREQKKHDCCIALLLSQIIFFEEQAAGIGKSAKIVVHLQPIPPNKEAGPYQSSKYSYIKLSFKEHGQIEFYRRLSEELSQKRWERISVSQPMQSPGRSQAGRVRAAGIVGIERKLEEKRKETDKNITEAFEDLSKLMKKAKEMVDLSKLIANKIKDKQGDISEDETIRFKSYLLSMGIANPVTRETHGSGTHYHMQLAKQLSGILQAPVEEQGGMMALTEVYCLTNRARGMELLSPEDLVNACKMFEALNLPMRLRIFDSGVMVVQLQSHNEDEMIASAVETVSERGFISSEEYAKLVGISVLLAKERLLLAEKVGHLCRDDSVESLRFYPNLFLTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQV9</accession>
    <name>A0A401NQV9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcriptional repressor CTCF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">11-zinc finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">CCCTC-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">CTCFL paralog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0007366</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CTCF zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002652">
        <property type="protein sequence ID" value="GCB63260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQV9"/>
    <dbReference type="STRING" id="75743.A0A401NQV9"/>
    <dbReference type="OMA" id="CQANIAD"/>
    <dbReference type="OrthoDB" id="9888716at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000222">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000283">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000373">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000420">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000049">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000123">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF34">
        <property type="entry name" value="ZINC FINGER PROTEIN 672-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="565"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB63260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="721" mass="82424" checksum="603E85A92DCF570B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQX7</accession>
    <name>A0A401NQX7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005330">
        <property type="protein sequence ID" value="GCB63313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NQX7"/>
    <dbReference type="OMA" id="GQVTQGW"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specific factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002223">
        <property type="entry name" value="Cleavage and polyadenylation specific factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000100">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000118">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000544">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="30"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="497"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1436" mass="161900" checksum="A386B035B4A371FA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRA7</accession>
    <name>A0A401NRA7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006653">
        <property type="protein sequence ID" value="GCB63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRA7"/>
    <dbReference type="STRING" id="75743.A0A401NRA7"/>
    <dbReference type="OMA" id="MCHKAKL"/>
    <dbReference type="OrthoDB" id="29657at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF12">
        <property type="entry name" value="PROTEIN GPR107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="13626" checksum="59EB2AC117CCC538" modified="2019-05-08" version="1" fragment="single">AAVNLAKLKLFRHYYVMIVCYIYFTRIIAILIKIIVPFQWKWLYQFLDELATLVFFSLTGYKFRPASDNPYLQLPQNEEDVEMDEVVTTTGIMEGIKKVNQTSNGPAEQRGEQNRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRT5</accession>
    <name>A0A401NRT5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005364">
        <property type="protein sequence ID" value="GCB63611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRT5"/>
    <dbReference type="STRING" id="75743.A0A401NRT5"/>
    <dbReference type="OMA" id="PHWRRTS"/>
    <dbReference type="OrthoDB" id="8749238at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01385">
        <property type="entry name" value="CLAUDIN14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="234" mass="25691" checksum="420D91CD95DC2098" modified="2019-05-08" version="1">MAHMGIQIIGFFLGLFGLFGTLVATVLPHWRRTAHVGADIIMAMEFMKGLWMECVWQSTGIYQCQVHRSQLALPPDLQAARAMMVISCLLSALATCISIMGMKCTVCLKESSSKNSIAVSGGICYILAAIMCLIPVSWSTNDLIRDFYNPMIPPGNKYEMGEALYIGFVSTSVMLIGGTLLCLSCPQQRNGWPYQPRDSFVQTAPPCRLPAVCKGNPTSQPLASHSSYRLHDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSU0</accession>
    <name>A0A401NSU0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inter-alpha-trypsin inhibitor heavy chain H2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0000218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITIH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000038">
        <property type="protein sequence ID" value="GCB63946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSU0"/>
    <dbReference type="STRING" id="75743.A0A401NSU0"/>
    <dbReference type="OMA" id="DSEEAVX"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030212">
        <property type="term" value="P:hyaluronan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01461">
        <property type="entry name" value="vWA_interalpha_trypsin_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000013">
        <property type="entry name" value="inter-alpha-trypsin inhibitor heavy chain H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010600">
        <property type="entry name" value="ITI_HC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF14">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06668">
        <property type="entry name" value="ITI_HC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019376880" description="Inter-alpha-trypsin inhibitor heavy chain H2" evidence="9">
        <location>
            <begin position="19"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="11">
        <location>
            <begin position="60"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="314"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB63946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="106652" checksum="EA998958CECEE118" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTG9</accession>
    <name>A0A401NTG9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0004558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001353">
        <property type="protein sequence ID" value="GCB64176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NTG9"/>
    <dbReference type="OMA" id="CPETIIT"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000017">
        <property type="entry name" value="KN motif and ankyrin repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047184">
        <property type="entry name" value="KANK1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021939">
        <property type="entry name" value="KN_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168:SF19">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12075">
        <property type="entry name" value="KN_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1225"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1258"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="970"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1321"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="971"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB64176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1344" mass="146898" checksum="D9AC025D33950AA8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU44</accession>
    <name>A0A401NU44_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000050">
        <property type="protein sequence ID" value="GCB64395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU44"/>
    <dbReference type="STRING" id="75743.A0A401NU44"/>
    <dbReference type="OMA" id="DQWAMDG"/>
    <dbReference type="OrthoDB" id="406096at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="21117" checksum="470B34D331C9C872" modified="2019-05-08" version="1">MHGSIVDGQHGSIVDSTIASQFQGPRFDSGLGVYKNLEARLMLLMYHVKASAQASISKIKDQWAMDGYVSAEPDGATYVFQGFIQGEDYGQFGVQRLGLNSTHGSNSPNPPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSAEGKAVRFDPNLNTVCTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU63</accession>
    <name>A0A401NU63_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000050">
        <property type="protein sequence ID" value="GCB64384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU63"/>
    <dbReference type="STRING" id="75743.A0A401NU63"/>
    <dbReference type="OMA" id="DWFSGMN"/>
    <dbReference type="OrthoDB" id="5804959at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="2">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="9659" checksum="AEBBF5B18CA75F64" modified="2019-05-08" version="1">MKEGVKDWFSGMNLPPPIISSKNWLRLHFVSDNNHRHRGFSAQYQVKKSIDFKSRGVKLFPGKDNSNKFSICESTFLLPFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU84</accession>
    <name>A0A401NU84_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008053">
        <property type="protein sequence ID" value="GCB64446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU84"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="108" mass="12602" checksum="8E67A45048937D7B" modified="2019-05-08" version="1">MTGSRTRAHQLWTQKQDWIENQGTPSLDPETGLDQEPGYTISGSRNRTGSRTRTHHLWIQKQDTHLWIQKQDTPSLDPETGLDLEPVHTISGSRNRTHHLWIQKQDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVY8</accession>
    <name>A0A401NVY8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor BTF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0004705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001411">
        <property type="protein sequence ID" value="GCB65040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVY8"/>
    <dbReference type="STRING" id="75743.A0A401NVY8"/>
    <dbReference type="OMA" id="RMQQSVR"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="79"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB65040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="204" mass="22424" checksum="BA7842143AD7DD5A" modified="2019-05-08" version="1">MDAIPPPRRQLIGWSPVSRPPSLSISAILLTACFLWVRANIIRGNTMNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGQVIHFNNPKVQASLSANTFAITGHAETKQITEMLPGILSQLGADSLTSLRKLAEQLPRQVLDNKTPKAEDIDEEDDDVPDLVENFDEASKNEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXE5</accession>
    <name>A0A401NXE5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0007739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002857">
        <property type="protein sequence ID" value="GCB65536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401NXE5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SH2_BLNK_SLP-76"/>
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        <property type="entry name" value="B-cell linker protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoreceptor_sig_adapters"/>
    </dbReference>
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        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="B-CELL LINKER PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SH2 DOMAIN CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="453"/>
            <end position="560"/>
        </location>
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            <begin position="37"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="74"/>
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        <location>
            <begin position="83"/>
            <end position="97"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="563" mass="62331" checksum="FC2C37CC43EC5AF2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYZ6</accession>
    <name>A0A401NYZ6_SCYTO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">scyTo_0011948</name>
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        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005625">
        <property type="protein sequence ID" value="GCB66075.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="292" mass="31283" checksum="4EE279856BED59D8" modified="2019-05-08" version="1">MCAYRICVESGMCVNVACVESGMCVHMACVESGMCVHMACVVSGMCVHVACVESGMCVHMACVESGLSAQGVCGVWYVCAHGVFGVWNVCVLGVFGVWYVCALGVCQAWYVRAQGVCGVWYVCALGVCVVSGMCVHRACVESGMCVHLACVVSGMCVHWACVESGMYMHRACVESGKCVRRACVESGMCVRRACVESGMCAYRMCVESGMCVRMACVESGMCVHMACVESGMCEHMACVVSGLSAQGVCSVWYVCAHGVCRVWYVCARGMCRVWYVCAHAMCSVWFVCTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ94</accession>
    <name>A0A401NZ94_SCYTO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">scyTo_0000560</name>
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    <organism evidence="2 3">
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        <name type="common">Cloudy catshark</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000101">
        <property type="protein sequence ID" value="GCB66189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401NZ94"/>
    <dbReference type="OrthoDB" id="8962274at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="14231" checksum="E3454D32302A1557" modified="2019-05-08" version="1">MVLEKGVAQRPGWKLDEELLGNQVYCEKIEKVIKEYVGFNRTGEVSKAVVWVSLKAVVRGEVILFKARVDKEERLERQRVIDEMLEVVRSYAEDGGPAKLEKRKEPQASFDRLSTRKAVRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0E4</accession>
    <name>A0A401P0E4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Carcharhiniformes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008310">
        <property type="protein sequence ID" value="GCB66605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0E4"/>
    <dbReference type="STRING" id="75743.A0A401P0E4"/>
    <dbReference type="OrthoDB" id="27593at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="376" mass="41704" checksum="5472E28D8C7C58A8" modified="2019-05-08" version="1">MDLEHRRIRQGRKRQRLREMHISNGEEMEPLKDCLQESPCLKNHITIRKEDSVLPDLMLIGKKRINTSLGPGAAERPNGEEGRAEEKQDAETQRDAAHPLCRQQGLRSKADLKRQCALPFIEWNAERDPQLHFRASQSELTPGRGSAESLPPYHASEDSGHALFGRQVMGKADSWPHQSLATKSNFTTTSKSDGSLETLLAKSERGESSGLQRRPSQGSDQEKTTRRKVRVYSTDSPSDESFSSESLDCGSIFSGTLFDNDLKDNDFLMNSFSLEDDAGPSDDSASSDELPSDSLPGLEPDPEIPCHLPATDSLRPMSCIAGCIEQEKRRFSASELINRLHLSQKKVAQALKLSKSLSGRSISREKTSALSFEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0J4</accession>
    <name>A0A401P0J4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Progesterone immunomodulatory binding factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002953">
        <property type="protein sequence ID" value="GCB66648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0J4"/>
    <dbReference type="STRING" id="75743.A0A401P0J4"/>
    <dbReference type="OMA" id="XVLTKEF"/>
    <dbReference type="OrthoDB" id="299638at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026205">
        <property type="entry name" value="PIBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950:SF0">
        <property type="entry name" value="PROGESTERONE IMMUNOMODULATORY BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950">
        <property type="entry name" value="PROGESTERONE-INDUCED BLOCKING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="633"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="89889" checksum="37CC9ABC0E0F06BC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0M3</accession>
    <name>A0A401P0M3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004306">
        <property type="protein sequence ID" value="GCB66654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0M3"/>
    <dbReference type="STRING" id="75743.A0A401P0M3"/>
    <dbReference type="OrthoDB" id="6077228at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF5">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="2">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="142" mass="16256" checksum="51518E551ED9C645" modified="2019-05-08" version="1">MDKSSGSSEIKWSSVSLPLDLIVGKFRLPTLARLSQGEYIEGLSEQDLLLIHSCRQWTTVTAHSLEEGHYVIGPKIDIPLQYLGKFKLLDQDRDVREPVQYFNSVEEVANVFPDRVFVMEAITFSVKVSGVKSEIYLFRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1C5</accession>
    <name>A0A401P1C5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial genome maintenance exonuclease 1</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MGME1</name>
        <name evidence="10" type="ORF">scyTo_0013632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGME1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01007053">
        <property type="protein sequence ID" value="GCB66914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1C5"/>
    <dbReference type="STRING" id="75743.A0A401P1C5"/>
    <dbReference type="OMA" id="DCVAKYQ"/>
    <dbReference type="OrthoDB" id="5777131at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008297">
        <property type="term" value="F:single-stranded DNA exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000005">
        <property type="entry name" value="Mitochondrial genome maintenance exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03030">
        <property type="entry name" value="MGME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK endonuclease-like" evidence="9">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB66914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="350" mass="39881" checksum="CE5D959AF701BDF2" modified="2019-05-08" version="1">MNYFIVPNAAMCKVLENSFKQHWGAVRKELVFQCHNLSTFPTLRCQGKGLSKYEQVDPKKYASLVRSVVSTKVSPQTPETLLGEDSLLYGPVRRSKPANDEPEPESPQNLAPFLNSECQIAEHEPGSVLKLPLQILSKRNCSKTNLSSVTRILQLTMSLEQAFYLERWKRRMITELGQDGFKEYTKNILNRGKLFHTALEESLLSTKIPKTDDEEIAGYLHSVQDILADVKGTRALESVVSHLPLQYMGLVDCVAEYRGKLCVIDWKTSEKPKPYFRNTFDNPLQVAAYAGALNHDDNYNFQVERGLIVVAYKDGSPAHAHFMDRELFLTCWKKWLFRLKKYKDKIGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4K2</accession>
    <name>A0A401P4K2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mediator complex subunit Med12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0010342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004435">
        <property type="protein sequence ID" value="GCB68037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P4K2"/>
    <dbReference type="OMA" id="IICEEDW"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021989">
        <property type="entry name" value="Mediator_Med12_catenin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12144">
        <property type="entry name" value="Med12-PQL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="10">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="597"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1292"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1578"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1795"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1975"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1908"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1292"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1600"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1622"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1799"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1976"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB68037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2018" mass="227451" checksum="34E8C40B98B55BEF" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P563</accession>
    <name>A0A401P563_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003095">
        <property type="protein sequence ID" value="GCB68285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P563"/>
    <dbReference type="STRING" id="75743.A0A401P563"/>
    <dbReference type="OMA" id="HMIRWRI"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23344">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23344:SF50">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="9">
        <location>
            <begin position="173"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB68285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="509" mass="59327" checksum="E9C4595804E9BBFC" modified="2019-05-08" version="1">MERQIILTLKNLCSTCVTGIYGCQWKKNPPRPNKKKERIWWLVLSCTFGICVFWFYCWWAMRNDYSNLNEHLFEKMHRWLDWSVILLTLAAFIFSYLLLLMILALCHFALGLLLYLHWINKVAILILVLLILILMIVIGIKWKEEWDTIGLSLQVTAPFLHIGAVVGVTSVAWVVIAQFFQSKRRQNTIMSFEETVKCEASTFETDVRISYDGVPFLMHDSTFERTTDIAEVFPKKVRSDVSNFTWSEIQKLNAGKWFLKKDPYSTVRTLSEESRRNASKQHVCSLADLLHLAAKKKKYVMFDLRPPTNLCHPYHNNSHSIVVETILLSLIHQNQILWLPDNKTDTPKDFQMIAGEKLAPETLRKENIRTINIRYSSISFSEIRNYAAKNISTNLYVVNERWLFSTLWCARVSSVTTNACHIFKNMNEPIWHINPGTYLAMWIITDLVSFLLIVSIYFIQRSKYKKIKGEPQSYQPELLAETGEPQSYQPELLAETEVKMKEDSEDTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6U1</accession>
    <name>A0A401P6U1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0015258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:15991"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008571">
        <property type="protein sequence ID" value="GCB68836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6U1"/>
    <dbReference type="STRING" id="75743.A0A401P6U1"/>
    <dbReference type="OMA" id="YICPHED"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="HMG_CoA_Rdtase"/>
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        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
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        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
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    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="3" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="3" id="KW-1207">Sterol metabolism</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="61"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049909"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB68836.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="667" mass="75055" checksum="BE2B6F24006C905D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7A5</accession>
    <name>A0A401P7A5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0000979</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB68983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
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        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="I-set"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019043474" description="Ig-like domain-containing protein" evidence="14">
        <location>
            <begin position="45"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="354"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB68983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="640" mass="72091" checksum="02174EE0DB28874D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7P5</accession>
    <name>A0A401P7P5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0005426</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001683">
        <property type="protein sequence ID" value="GCB69128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P7P5"/>
    <dbReference type="OMA" id="DRTIAQX"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000543">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000009">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF13">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1974"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2253"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2582"/>
            <end position="2780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="894"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3207"/>
            <end position="3244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3437"/>
            <end position="3478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3736"/>
            <end position="3763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="894"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB69128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="4590" mass="525592" checksum="2DCA0288645DD2CD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P849</accession>
    <name>A0A401P849_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004564">
        <property type="protein sequence ID" value="GCB69284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P849"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="47" mass="5404" checksum="5F3280436BE72D44" modified="2019-05-08" version="1" fragment="single">HTSDRMWDLHKSTGVITGTVLAFLLLSFIVWAIIRRRKAIQEKPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9P0</accession>
    <name>A0A401P9P0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dedicator of cytokinesis protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004635">
        <property type="protein sequence ID" value="GCB69887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P9P0"/>
    <dbReference type="OMA" id="MEDWISI"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060997">
        <property type="term" value="P:dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF71">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="119"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="614"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="1629"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1224"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB69887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2092" mass="237720" checksum="9F295C2AE4EF667B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB33</accession>
    <name>A0A401PB33_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Double-stranded RNA-binding protein Staufen homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0001246</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000272">
        <property type="protein sequence ID" value="GCB70319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB33"/>
    <dbReference type="STRING" id="75743.A0A401PB33"/>
    <dbReference type="OMA" id="GMTHITE"/>
    <dbReference type="OrthoDB" id="10056847at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19879">
        <property type="entry name" value="DSRM_STAU1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19887">
        <property type="entry name" value="DSRM_STAU1_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000014">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000024">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000013">
        <property type="entry name" value="double-stranded RNA-binding protein Staufen homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF2">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="108"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="221"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="321"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB70319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="641" mass="70335" checksum="F018828B84D74026" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB99</accession>
    <name>A0A401PB99_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0008564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003309">
        <property type="protein sequence ID" value="GCB70391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB99"/>
    <dbReference type="STRING" id="75743.A0A401PB99"/>
    <dbReference type="OMA" id="PYNLITH"/>
    <dbReference type="OrthoDB" id="6252992at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2 C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="7">
        <location>
            <begin position="344"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB70391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="500" mass="55376" checksum="DAE3B6B2A2A2D1F3" modified="2019-05-08" version="1">MGETQAGKKPDILHIKTEKEETSDFNAQCVMKDENRNQNRELKNYHLGNNSFAAGQSAGHNISSPDTCSVSNGYRKRSSSVPDDQCSSSSIMSHCNNGKVHIAELHHSPHPMSRGSCLTGSLVENTMKPSDVSTGEYCIGSAKLANHDRSGSNLGPLLDSDYARSLTHNRVNSDVGNPELHCDPPEPSGQEGVLEFLHTILKADVVDEIFSNVRLANETDVEVLTENLSGKEDLLLDAGIQTNARLYFSAGGWAAVSATLEVLGTLERSKGDQDMEDRITEDGLSQDERFSARGQCFVSDSGPELMIINPYPSCNMLNAAAMDEEQIVVAHVPALLPSADDKKRKVKYPVTKGEIRRRIIPPEKMSKTVIKSYLRLRRDNRFDIRQLLDLPVTGYDRTLHTSFTRLCEGEAKTLTENFHQLNLGYFPVDECASTIAEHAAASEIYAARQVIDDLDTIMDSFMWQEHPYNLITHGFGPQNIKVVLDLVKLLLRESLRKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCP5</accession>
    <name>A0A401PCP5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MiT/TFE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001858">
        <property type="protein sequence ID" value="GCB70879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCP5"/>
    <dbReference type="STRING" id="75743.A0A401PCP5"/>
    <dbReference type="OMA" id="GIPMANT"/>
    <dbReference type="OrthoDB" id="6242697at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18926">
        <property type="entry name" value="bHLHzip_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000003">
        <property type="entry name" value="microphthalmia-associated transcription factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021802">
        <property type="entry name" value="MiT/TFE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF4">
        <property type="entry name" value="MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11851">
        <property type="entry name" value="DUF3371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="278"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB70879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="489" mass="54647" checksum="BD0C0F76BC6C6468" modified="2019-05-08" version="1">MFRPCPFQSFYINSSEPQGSAKPPLTSSNMTSRILLRQQLMREQMQEQERREQQQQQQAAQFIQQRVPVSQTQAINVSVPTSLPTNTQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLGNKLSNQALSMPCSNQPSDHAMPPGTGSSAPNSPMAMLNISSNCEKEMDDVIDDIISLESSYNDEILGLMDPGIPMANTLPVPGNMLDVYSNPGMAAPAITISNSCPANLPNIKRELAESMVAGMELHFKSPSMKMHNALLPEAEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRRLQKEQHRAKDFESRQKKLEHANRHLLLRIQELEMQARAHGLPLVNPSGLCSPDLTGRNIKLELVRNECHNDSLQHHSDLSRTTTLNLADGTLTFNDNLGHAVTYNAPTKMGSKLDDILMDDTLSPVEATDPLLSSVSPGASKTSSRRSSMSMEDSENGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCU0</accession>
    <name>A0A401PCU0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003388">
        <property type="protein sequence ID" value="GCB70936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCU0"/>
    <dbReference type="STRING" id="75743.A0A401PCU0"/>
    <dbReference type="OMA" id="KMEMTRK"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20579">
        <property type="entry name" value="CYCLIN_CCNE1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000024">
        <property type="entry name" value="G1/S-specific cyclin-E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 8" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="11">
        <location>
            <begin position="300"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB70936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="472" mass="53962" checksum="A478C6B60A7B6930" modified="2019-05-08" version="1">MTTSSSRERALDSRQRFKGSSAGAVAWLSRSGAGSEREPARGGLIREIFNTPSTPKMPRKSEIINQSTKAEETKEIVLRSRKRKANVAICLQDLDEVTEVQTTKPYEKEACWNTVSNCIRPYRLNSTLHKNPDDVVTSNSISYVECRFKNVLVTPTRASPLPVLCWGNCDEVWNILLKKEQAYLRDKDVLQKHPLLQPKMRTILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQQNVVKTRLQLIGISALFIAAKLEEIYPPKLHQFAYVTDGACTEEEILNMELVVLKALKWSLCPITIVSWLNIYMQVAYLQEIYEILIPQYPQEMFVQVMELLDLCILDLKCLEFTYGVTAASALYHFSSYELVHKVSGFEWSEIEGCVKWMVPFAMALREMGSIKLKKLKGVWPEDLHNIQTHSNSLSLLDKAHTKQALLLEQSRCSPVPSGILTPPQSSKKHNSGVGPHEHHLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD21</accession>
    <name>A0A401PD21_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DET1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003398">
        <property type="protein sequence ID" value="GCB71020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD21"/>
    <dbReference type="STRING" id="75743.A0A401PD21"/>
    <dbReference type="OMA" id="NGLNHTQ"/>
    <dbReference type="OrthoDB" id="18339at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB71020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="63968" checksum="8B93100933E2BEFC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDF4</accession>
    <name>A0A401PDF4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001889">
        <property type="protein sequence ID" value="GCB71139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDF4"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="148" mass="16164" checksum="AA19789F5042F3A8" modified="2019-05-08" version="1">MGTVSSIRFRRGAGEQNASSRRLRPQKAKGCRSHAGRAEPRRGRGACSRETDPNRGAADRQLGSDSHPAPCNLNKENPHGQLDEDSNVDGKSPLDFGTAFGTNDPGKPTVRICTMESSPTEMKDVDSSCLEFLKPDNPEKMWIRLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDH2</accession>
    <name>A0A401PDH2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000334">
        <property type="protein sequence ID" value="GCB71162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDH2"/>
    <dbReference type="OrthoDB" id="10398484at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="175" mass="19949" checksum="DD2CB471772131A6" modified="2019-05-08" version="1">MIRSSESTSIVNSLQENDILEKLTLVEEHQELNNISDHPKETDITKLNDTSDHTKRPDITKFKDTPDNTKDTVTKMFKNESAKTRGTDLEHTKSDYGTTECTQRYGCETKGQLNNTLQFNDKKVFELAVTLDKPYSMESNTDGIRATDCKTVCGKTATIRDKTDKCVYRQYKVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEB0</accession>
    <name>A0A401PEB0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox protein Nkx-2.5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Homeobox protein NK-2 homolog E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0008843</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003471">
        <property type="protein sequence ID" value="GCB71456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEB0"/>
    <dbReference type="STRING" id="75743.A0A401PEB0"/>
    <dbReference type="OMA" id="CNASYSC"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000078">
        <property type="entry name" value="NK2 homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF28">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-2.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB71456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="327" mass="37091" checksum="0BAB5CC7CA7E8EC1" modified="2019-05-08" version="1">MFSGAATSTPFSVKDILNLQQHPDMASLSESTGLDLPPSPASCMLARTKQQHYSDTQAMATYNELLPKLNSCKNHPNYSSSSFANNYLEMDSREAKPSNGATGNTKGKKEFYKCLKHFHFMYNVKCRLMEVNTGKEGQKSDEADRPRRRRRKPRVLFSQAQVYELERRFKQQKYLSAPERDHLANILKLTSTQVKIWFQNRRYKCKRQRQDKSLEMVGLPPPRRIAVPVLVRDGKPCLGESSPYNSPYNMNISPYAYGTYANYTNYSGAATTANYSCNYPSVQAMPPSTATSSFMNMNFTVNELNSAVQTQIHQNTGVSTLHGIRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEK7</accession>
    <name>A0A401PEK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G protein-activated inward rectifier potassium channel 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cardiac inward rectifier</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Heart KATP channel</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Inward rectifier K(+) channel Kir3.4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">KATP-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Potassium channel, inwardly rectifying subfamily J member 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0008867</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21">Membrane</location>
            <topology evidence="1 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003489">
        <property type="protein sequence ID" value="GCB71556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEK7"/>
    <dbReference type="STRING" id="75743.A0A401PEK7"/>
    <dbReference type="OMA" id="ISMRDDK"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015467">
        <property type="term" value="F:G-protein activated inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000019">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000005">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003277">
        <property type="entry name" value="K_chnl_inward-rec_Kir3.4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF52">
        <property type="entry name" value="G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01330">
        <property type="entry name" value="KIR34CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 21" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 21" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <keyword evidence="8 21" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="24">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="25">
        <location>
            <begin position="199"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="20">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB71556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="440" mass="50082" checksum="83997C2F7C6D184B" modified="2019-05-08" version="1">MAGDSRVLPNTGMDIRATTRESKKLPKQARDNILTTDRTRLFAEPKKIKQRYVDKDGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLIFTLVFTVTWLFFGFIWWLIAYIRGDLDHLEDPTWTPCVDNLNGFVSAFLFSIETETTIGYGHRVITEKCPEGIILLLIQAILGSIVNALMVGCMFVKISQPKNRAETLMFSNRAVISLRDEKMCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINEKSPFWEMSRSQLEKEDFEIVVILEGMVEATGMTCQARSSYSDSEVLWGHRFNPVLTLEKDFYEVDYNSFHETYETNTPDCSAKQVAAMKRAGQVLPELSCPHLPSKEVEAAKEENAGKGHLSTNSPTAKTEPFSPIEDSEYCTGFSARFIQGLEEAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF65</accession>
    <name>A0A401PF65_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 39A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0008909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003521">
        <property type="protein sequence ID" value="GCB71734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PF65"/>
    <dbReference type="STRING" id="75743.A0A401PF65"/>
    <dbReference type="OMA" id="RFKQLIF"/>
    <dbReference type="OrthoDB" id="5862608at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902902">
        <property type="term" value="P:negative regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901097">
        <property type="term" value="P:negative regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB71734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="55223" checksum="FF99FDCB8383571E" modified="2019-05-08" version="1">MPGGRRGPSRQQLSRSALPSLQTIVGGSCGNGTGMRNRNGSAIGLSAPPITALITPEPVRHCRIPDLPTDGCLVFELLFFIYLLMALLVQYINIYKTVWWFPYNHPAASTSLSFHLIDYHLAAFITIMLARRLVWTLVSEASQTSTTSIMWYTLLIVARLVLLTLCGWVLCWTLVNLFRNHSVLNLLFLGYPFGVYVPLCCFHQENRTQPLPAECGFLLNDQLETVMVRPKDFFTLLRESFREQFNNPTSIPAHTCPLSPDLIRNEVECLKADFNKRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCEHLIMVWVNAFVMLMSQLLPPRYCDLLHKSAAHLGKWQKMEHGSYSNTPQHIWSETTIWPQGVLVRHNRCLYKAVGPYNVAVPSDVSHARFYFLFHKPLRILNLLILIEGSVVLYQLYSLLRSEKWNHILSLALILFCNYYVLFKLLRDRIVLGKAYAYPLGTIGLKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI90</accession>
    <name>A0A401PI90_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytosolic carboxypeptidase 1</fullName>
            <ecNumber evidence="16">3.4.17.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">ATP/GTP-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Protein deglutamylase CCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">scyTo_0006486</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:60004"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:60005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:63792"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="Rhea" id="RHEA-COMP:16436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:149556"/>
            <dbReference type="EC" id="3.4.17.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:63793"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.24" evidence="16"/>
    <dbReference type="EMBL" id="BFAA01002196">
        <property type="protein sequence ID" value="GCB72824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI90"/>
    <dbReference type="STRING" id="75743.A0A401PI90"/>
    <dbReference type="OMA" id="LEYNMPS"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06906">
        <property type="entry name" value="M14_Nna1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000024">
        <property type="entry name" value="ATP/GTP binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3120:FF:000001">
        <property type="entry name" value="cytosolic carboxypeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033852">
        <property type="entry name" value="CBPC1/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF24">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25571">
        <property type="entry name" value="TPR_CCP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="23">
        <location>
            <begin position="831"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="324"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1193"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="21">
        <location>
            <position position="1085"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GCB72824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1213" mass="137163" checksum="1FE4B3FE1096B60D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJR7</accession>
    <name>A0A401PJR7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Solute carrier family 12 member 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0002498</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000628">
        <property type="protein sequence ID" value="GCB73355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJR7"/>
    <dbReference type="STRING" id="75743.A0A401PJR7"/>
    <dbReference type="OMA" id="GEYQREY"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000040">
        <property type="entry name" value="Solute carrier family 12 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF54">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="248"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="539"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="658"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="885"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="776"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB73355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="106512" checksum="9E70CE901B8AAD08" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLZ4</accession>
    <name>A0A401PLZ4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000869">
        <property type="protein sequence ID" value="GCB74150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLZ4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="9142" checksum="505BCA4BFAAC756B" modified="2019-05-08" version="1">MDTIGANFKNRFLLPSTPKDIQPDIGVVPFSGILGAYASMLQHSPILASEALQNDASCVQSGFSLRRKETAYKDQQEKRKEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PM83</accession>
    <name>A0A401PM83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAM91 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0003278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000882">
        <property type="protein sequence ID" value="GCB74191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PM83"/>
    <dbReference type="STRING" id="75743.A0A401PM83"/>
    <dbReference type="OMA" id="CRSKIMW"/>
    <dbReference type="OrthoDB" id="275996at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="374"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB74191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="93909" checksum="425314177C03ED3E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMC6</accession>
    <name>A0A401PMC6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAIN-B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0003319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000891">
        <property type="protein sequence ID" value="GCB74231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMC6"/>
    <dbReference type="STRING" id="75743.A0A401PMC6"/>
    <dbReference type="OMA" id="HCVVWDD"/>
    <dbReference type="OrthoDB" id="5989160at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007422">
        <property type="term" value="P:peripheral nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000004">
        <property type="entry name" value="Adhesion G protein-coupled receptor B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008077">
        <property type="entry name" value="GPCR_2_brain_angio_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF41">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01694">
        <property type="entry name" value="BAIPRECURSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GAIN-B" evidence="6">
        <location>
            <begin position="116"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB74231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="288" mass="31949" checksum="491B49A5202306EC" modified="2019-05-08" version="1">MIQVIRTMLGLMERKNFYSGDLLFSADILRNVTDTFKRASYIPASGDIQKFFQIISYMLEAENREKWDDALQVAPGSIYLMRVVEDFIHVVGQGLKVFQSALIVTDNLVTSIQREPVSAVSSDISFPMKGRRGMKDWARNSEDKLYIPKEVFMVSSSEIDDSAYYIIGAVLYRTLGLILPVAKKSMAINSKVLAVTVRPQPKASQPVVVELSHLINGTSNPHCVVWDDSKTDSGPGSWNPQSCETVKTQAAHTICLCNQLATFAILAQKPRDSMSCPPEPAKRPTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNL9</accession>
    <name>A0A401PNL9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0003762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01001056">
        <property type="protein sequence ID" value="GCB74671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNL9"/>
    <dbReference type="STRING" id="75743.A0A401PNL9"/>
    <dbReference type="OMA" id="NCYDSEG"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16206">
        <property type="entry name" value="EFh_PRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000017">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000001">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF85">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="511"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="627"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB74671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="963" mass="109202" checksum="4D55578B4355AC09" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPW8</accession>
    <name>A0A401PPW8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thymosin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0018969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013694">
        <property type="protein sequence ID" value="GCB75169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPW8"/>
    <dbReference type="STRING" id="75743.A0A401PPW8"/>
    <dbReference type="OMA" id="CERQPIM"/>
    <dbReference type="OrthoDB" id="2151618at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.520:FF:000001">
        <property type="entry name" value="Thymosin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12021">
        <property type="entry name" value="THYMOSIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12021:SF26">
        <property type="entry name" value="THYMOSIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00500">
        <property type="entry name" value="THYMOSIN_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB75169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6834" checksum="794E1C459BE71878" modified="2019-05-08" version="1" fragment="single">RLRVSEAARHTGLTEMEDKPDFREVASFDKSKLRKTDTEVKNTLPTKETIDQEKKAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQI8</accession>
    <name>A0A401PQI8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0015314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008632">
        <property type="protein sequence ID" value="GCB75388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQI8"/>
    <dbReference type="STRING" id="75743.A0A401PQI8"/>
    <dbReference type="OMA" id="ICANERR"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000024">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit ERF3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EFTu-like" evidence="6">
        <location>
            <begin position="136"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GTP-eEF1A C-terminal" evidence="7">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB75388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35876" checksum="EC8AB94A72386BAC" modified="2019-05-08" version="1">MPEVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVSWSQDRYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKERADNCSWYTGLPFIPYLDNLPHFNRISNGPVRVPIVDKYKDMGTVVLGKLESGLIGKGHQLVMMPNKHNVEVLGLLSDDVETETADPGENLKIRLKGIEEEEILPGFILCDHGSLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVQIAALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLIPEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQX1</accession>
    <name>A0A401PQX1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011204">
        <property type="protein sequence ID" value="GCB75513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQX1"/>
    <dbReference type="OMA" id="HQRLYNS"/>
    <dbReference type="OrthoDB" id="9909100at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="198" mass="21185" checksum="58D5E9D59ECC7E92" modified="2019-05-08" version="1">MGPAGASENGTENTVGPLSSTAERRPTASPQGPRETQSSPSPSGRPGVPSPPLTETPASTTRTCCEAPALSGENDTETEKRQYRKTLGVFVGLAVVLLLVFGLVYLIYNRTQKDDPFSHQRLYNSDPVLSLDVSVEPADRFYGSLTSDLGREGQGDHVTSQRALNQSAGEAKGPNSPLQTRDEIQLKPLSESSVKIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR03</accession>
    <name>A0A401PR03_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FATC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008663">
        <property type="protein sequence ID" value="GCB75554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR03"/>
    <dbReference type="STRING" id="75743.A0A401PR03"/>
    <dbReference type="OMA" id="MCLIELA"/>
    <dbReference type="OrthoDB" id="431717at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033152">
        <property type="term" value="P:immunoglobulin V(D)J recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF68">
        <property type="entry name" value="DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FATC" evidence="1">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="13092" checksum="C9AED25EBEB68BC3" modified="2019-05-08" version="1" fragment="single">NFERNQLKKEGSWSKEVNTNEINWYPKQKVNCAKRKLEGANPSAITRDELRLGHEKSKAYTSYIAVAMGDQDHNVRAREPEEGLSVECQVDCLIDQATDPNILGRVWVGWEAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRQ4</accession>
    <name>A0A401PRQ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0019809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015137">
        <property type="protein sequence ID" value="GCB75802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRQ4"/>
    <dbReference type="STRING" id="75743.A0A401PRQ4"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048156">
        <property type="term" value="F:tau protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000029">
        <property type="entry name" value="myc box-dependent-interacting protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF4">
        <property type="entry name" value="MYC BOX-DEPENDENT-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="173"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB75802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="246" mass="26599" checksum="460092838F6D6450" modified="2019-05-08" version="1" fragment="single">FEAPGPLQDEGSLLDFDFDPLKPESSPVVRAASPVSQSIPWDLWEPEKSASNSMAMDHSPSMAMGDGPSESSFAVDWSAQPHLQENKGVTAEAAEPDNASSEVTMKGAEEKAAPVTSEGKSEPKEDVLENETGADVATAKDVLPAVVTETLPATTNGAVYDTVPSEEIEMPPGFQFKVRALHDYNATDSDELNLKAGDVVLVLAHENPEEQDDGWLMGIKEIDWIQQKDLKSAKSVFPENFTERVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS24</accession>
    <name>A0A401PS24_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016454">
        <property type="protein sequence ID" value="GCB75903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS24"/>
    <dbReference type="OrthoDB" id="9947983at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1171" mass="124847" checksum="2945E3063E03855C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSK9</accession>
    <name>A0A401PSK9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metaxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0017427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011314">
        <property type="protein sequence ID" value="GCB76114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSK9"/>
    <dbReference type="STRING" id="75743.A0A401PSK9"/>
    <dbReference type="OMA" id="ANYFFGN"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03212">
        <property type="entry name" value="GST_C_Metaxin1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017410">
        <property type="entry name" value="Metaxin1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF30">
        <property type="entry name" value="METAXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038150">
        <property type="entry name" value="Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="10">
        <location>
            <begin position="173"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB76114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="257" mass="29344" checksum="9210BE3CC07161BD" modified="2019-05-08" version="1">MASPMELMCWGGDWGLPSVHTDSLIVLAYAKFSRAALKVHFINNPWKTPTGDIPVLTSDNTNVVQPKNILNFLRKQKYNADYELSAKEGADTLAFIALMEEKLRPALLHTFWVDIENYCNLTRPWFASRIPFPLNFYLPGQMSRSAMNQIVLTKGEPPFYNLKDVEAQIYRDAKECLNLLSYRLGESNFFFGKIPTSFDAFAFGFLAPLCKAELPNAHLQKHLHQLHNLCQFCENILTQYFIQNSTDGRQSSQQPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUK2</accession>
    <name>A0A401PUK2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0015557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008875">
        <property type="protein sequence ID" value="GCB76814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PUK2"/>
    <dbReference type="OMA" id="PFSCIVS"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="48"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="224"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="317"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB76814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="512" mass="55216" checksum="4839024C8C2BD97D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUK4</accession>
    <name>A0A401PUK4_SCYTO</name>
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        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017508</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011447">
        <property type="protein sequence ID" value="GCB76807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUK4"/>
    <dbReference type="STRING" id="75743.A0A401PUK4"/>
    <dbReference type="OMA" id="CTKYEDA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08805">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000010">
        <property type="entry name" value="Ankyrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000002">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF71">
        <property type="entry name" value="ANKYRIN 1, ERYTHROCYTIC A ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
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            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
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            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
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            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
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            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="12">
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            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="12">
        <location>
            <begin position="569"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="11">
        <location>
            <begin position="862"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="945"/>
            <end position="970"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB76807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="970" mass="106451" checksum="A4DFCD04313AAA38" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYV1</accession>
    <name>A0A401PYV1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0018585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB78286.1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="immunoglobulin superfamily member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin superfamily member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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        <property type="entry name" value="LRFN"/>
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    <dbReference type="InterPro" id="IPR032675">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF4">
        <property type="entry name" value="MATRIX-REMODELING-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
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    </dbReference>
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        <property type="match status" value="8"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
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        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
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    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019030581" description="Ig-like domain-containing protein" evidence="12">
        <location>
            <begin position="31"/>
            <end position="2733"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="439"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="519"/>
            <end position="612"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="1757"/>
            <end position="1846"/>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="1854"/>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="1949"/>
            <end position="2041"/>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="2049"/>
            <end position="2142"/>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="2145"/>
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    <feature type="domain" description="Ig-like" evidence="13">
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    <feature type="domain" description="Ig-like" evidence="13">
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="2540"/>
            <end position="2629"/>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="2637"/>
            <end position="2728"/>
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        <location>
            <begin position="639"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        <location>
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        </location>
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        <location>
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        <location>
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        <location>
            <begin position="656"/>
            <end position="668"/>
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            <begin position="1204"/>
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        <location>
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        <location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2733" mass="300476" checksum="4B517441211C04C4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZL6</accession>
    <name>A0A401PZL6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011808">
        <property type="protein sequence ID" value="GCB78572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PZL6"/>
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    <dbReference type="OrthoDB" id="7881616at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
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        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
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        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40792" checksum="D4354A7D356AA2A5" modified="2019-05-08" version="1" fragment="single">SASPTQNQVIAGWKMYPQIPQYLVSRSEMHQFIERCMKAVGVKNSHAMALADVLVEGDYRGHYSHGLNRLDIYLKDMKSGICAKDGEPVIEKSTVATALVNGNNLMGPVVGNFCMDLAIQKAKEVGIGWVSAYGSNHYGIAGFYSMQALKCGFIGMSCTNTSPLVVATRAKECTLGTNPISVAAPALDGDSFVLDMATSAVALGKIEVQQRRNEEVPEGWGCDSNGKATTNPTQILTGGGQLPLGGSEATSGYKGYGLSMLVEVFCGMLSGSHYSNNIRRWKETDKVANLGQCFFAINPGCFAPNFEKRMSDLLNIHRTLEPSDPSLPVLIPGDPEALHIAECDHHGAIPYHVNVVDHMNSVAKELGVDLLPTNRTIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZN0</accession>
    <name>A0A401PZN0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0018618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013138">
        <property type="protein sequence ID" value="GCB78540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZN0"/>
    <dbReference type="STRING" id="75743.A0A401PZN0"/>
    <dbReference type="OMA" id="PPILICK"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="207" mass="23510" checksum="120ED956CEEBD59F" modified="2019-05-08" version="1">MCQPAQARISQHGQSCMSDCTCDEFCPECSVELSLDVKCNEDQTRHVTSRDLLSNNSRVIPVTSRSRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVSFEYDPDNALRHTVYPKPEEWPKSEYSELDDEEIQAPYDPNGKPERFFFNVESSGALRPETIVLSALSGLKKKLSDLQTMLSHEIQSDVLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0E2</accession>
    <name>A0A401Q0E2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009236">
        <property type="protein sequence ID" value="GCB78810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0E2"/>
    <dbReference type="STRING" id="75743.A0A401Q0E2"/>
    <dbReference type="OrthoDB" id="384877at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF4">
        <property type="entry name" value="PLEXIN-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="4">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="347" mass="38708" checksum="E4BACE5E7441FB20" modified="2019-05-08" version="1">MDPVKDVSLYVLLFNTLAALVVEVYPEDVFKFQTHIDNIAVSANGRVFVATENYLHQLNQSLKLEVLNQTGPLLDGPCVEQQGCCVKWNKTANMNKILVVDETRTRVLTCGTLRLGACNVRKLHNINQYETDQRPNVAAFHPEASTIAFLVKAQPVDYLVTATTSTGKFSRFVPPTCKVGSNYNENSDGTILLRNPTENVGDPKFLAFTEGESGDAAVKLNEAVELQYIHGFQWQKHIYILFNANNSVPEIIHMAISEYRVATVHSFSQATLLYPTSKKQALGVLSSALINLSSSQAFMVAIFSQQRQSENSPLYFYNLTQFNGYKKGGKSYFEIPNLKVSFLMVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q170</accession>
    <name>A0A401Q170_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009307">
        <property type="protein sequence ID" value="GCB79147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q170"/>
    <dbReference type="STRING" id="75743.A0A401Q170"/>
    <dbReference type="OMA" id="TGGANWI"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="58543" checksum="4CA1BA06A1C62E85" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q174</accession>
    <name>A0A401Q174_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Extended synaptotagmin-like protein 1b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0019492</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the extended synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014577">
        <property type="protein sequence ID" value="GCB79108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q174"/>
    <dbReference type="STRING" id="75743.A0A401Q174"/>
    <dbReference type="OMA" id="DIPDCYC"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08391">
        <property type="entry name" value="C2A_C2C_Synaptotagmin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04050">
        <property type="entry name" value="C2B_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000025">
        <property type="entry name" value="Extended synaptotagmin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000106">
        <property type="entry name" value="extended synaptotagmin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037733">
        <property type="entry name" value="Ext_Synaptotagmin_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037749">
        <property type="entry name" value="Ext_Synaptotagmin_C2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF3">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="168"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="310"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB79108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53793" checksum="4B8DEAACB62ACAC9" modified="2019-05-08" version="1" fragment="single">VLQQAWPFVGQYLEKLLVNSIAPIIRNSNNHLQTFAFTKVSFGVKPLKVHGVQVHTGTDKRQVTLDLHISYIGDCEINVEVKKYFCKAGVNGIQLHGMLRVILEPLIGNMPLVGAVTLFFIRRPVLDINWTGLTNLLDIPGLSSKSDTVLMDTIASFLVLPNRITCPLIGELHVAELRSPLPRGIVRIHLIEAASLESKDTYVKGFIKGKSDPYAIVRVGTQAFMSKTISESMNPKWNEMYEVIVHEVPGQLLEIEMFDKDPDQDDFLGRMQLDLGEVMKNQIVEEWFTLKDVERGKVRLKLEWLSLYSDPAKLEQALIVNNSITVQNSEEPSSAIMVVYVDQAQDLPLKQGTREPNALVQISLLDKTFESRTVYNTNSPAWEDAFTFFVQNPNQQDLDIQVKDDDRQLSLGSLSISLSQLLMSPDMSFDQWFPLEHSGRNSQIYLKIIMRFPFVSVFSLRLQVIIQYVLQLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2R7</accession>
    <name>A0A401Q2R7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013413">
        <property type="protein sequence ID" value="GCB79675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2R7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="10473" checksum="3190A9F5B7E6383B" modified="2019-05-08" version="1">MDYSHSLARIALDPGSNRQSYECLRTYPVCVLPPQGKSSKTAKRGSPDLPQAAGEGNGSEEIVYATLKVNGGPTAKYKAEPADNSVLYAAVKFRPEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2Z5</accession>
    <name>A0A401Q2Z5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009427">
        <property type="protein sequence ID" value="GCB79736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2Z5"/>
    <dbReference type="STRING" id="75743.A0A401Q2Z5"/>
    <dbReference type="OrthoDB" id="10266080at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF2">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="96"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="303" mass="34409" checksum="FA4F2298C87AC755" modified="2019-05-08" version="1" fragment="single">MEQERRSLGLGNGAGLEMTDFEKGQGRRSLTLRRGAGLGITDNVNRMLRSTRRSLRLKVRSCVFCVSKAGIERSISVEEKKPEQEASRYSAQSFFEYLVVVSLKKSGAAYEPQIAYQFPKRENLMRSQKEEEENLLKAIPLFCFPDCNTWAPLTEYESETFSFVLTKMDGSRKFGYCRRLLPRGGGARLPEVFCIISCLGCFGLFSQILDEVEKRRQISLAVIYPFMQGLREAAFPAPGKTVSVKSFIPESGTEIIKLTRPSDSRLEHVDFSSLFKHLSEENVIQIFASLLLERRLIFLAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q301</accession>
    <name>A0A401Q301_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0017948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB79738.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CNF-like_PLA2_Inhibitor"/>
    </dbReference>
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        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
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        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914:SF9">
        <property type="entry name" value="COILED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="LU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="5">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="5">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="5">
        <location>
            <begin position="220"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="370" mass="39197" checksum="C43BCB30591BC949" modified="2019-05-08" version="1">MLLSVCIAEIENRTLNGLECMGCLAVNGTCANLLSVVKCKGQQDRCAHTSGLLQGAFLTTYELKGCVSDFICRNPNNALGFYGINPTIGFYCCKDNLCNLVSRNFTKPDPTASPSSDPTQNMLHEVQPLNCNQCSGMSGTCIFESSTCKLGTTVCRTTSSTQIDGGMTKKQISNSCGPCSDPVSFNCGSVVVSQSSNCCDTDLCNTQVDTAPLNDTANGLQCRGCFSNSSDSCRDSEQTVKCVGAENRCMNVSGITDRLPGFTFFGKGCVSAQICQAVDSMIEFRMRFNELPTCCKGDFCNGDPEIGTSTPEPVITKSPVTPEISSKGPADSKGNVGCIVGSVIGVIVGFLIMVGVCCLCHKYKRESGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q371</accession>
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        </recommendedName>
    </protein>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013449">
        <property type="protein sequence ID" value="GCB79790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401Q371"/>
    <dbReference type="OMA" id="FMSHEPI"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cargo receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:clathrin adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47695:SF5">
        <property type="entry name" value="DISABLED HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47695">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PID"/>
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    </dbReference>
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        <location>
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            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="39"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="255"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="273"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="652" mass="68979" checksum="D5BD7C99649189EA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4Q9</accession>
    <name>A0A401Q4Q9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
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                <person name="Tatsumi K"/>
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                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
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                <person name="Terakita A"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012289">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401Q4Q9"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="12618" checksum="29A8E774ECCAF731" modified="2019-05-08" version="1" fragment="single">ATEEVVSADSVDSAIQQVVSSGGQQVITIVTDDIQLSSLRAASDCVNQPIIVTMQDGQQVLTVPATDIAEETVVTEEPLMKRHCVEVIENHAETTEIEIQESSGTESCTLRTVRFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q592</accession>
    <name>A0A401Q592_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0016240</name>
    </gene>
    <organism evidence="11 12">
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        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Carcharhiniformes</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009697">
        <property type="protein sequence ID" value="GCB80535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q592"/>
    <dbReference type="STRING" id="75743.A0A401Q592"/>
    <dbReference type="OMA" id="AICCQKF"/>
    <dbReference type="OrthoDB" id="10040416at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052477">
        <property type="entry name" value="Orphan_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272:SF6">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 139-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB80535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="324" mass="37193" checksum="71C854DEC15D00E6" modified="2019-05-08" version="1">MHGQVTGPVYAIYYPVLAAFGVPANLVTIVILSLGKCGLSKCITRYLVGMAVTDLLVIITGVILNRISVMYFPVRFLSITPVCSLKIALTYAARDSSVWLTVAFSFDRFIAICCQKFKTAYCTEKRAAIVIVILCVLSCVKNIPWYFVYEPLYMIKDTPWYCNIRTAFYSELAWTAFDWIDRILNPCIPFLLMLLFNALTVRHILSTLQIRRRLRSQSNAKKQSDPEMESRRKSIVLLFTISGSFVLLWMTYIVNFLYVRTTQDYKISGFNDPKFILQESGNMLQLLSCCTNTCIYAVTQSKFREQFMEILRYPMNLINKVAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q778</accession>
    <name>A0A401Q778_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTBD10/KCTD20 BTB/POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026592">
        <property type="protein sequence ID" value="GCB81254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401Q778"/>
    <dbReference type="OrthoDB" id="10034757at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTBD10/KCTD20 BTB/POZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="43" mass="4859" checksum="B97929845B3789F1" modified="2019-05-08" version="1" fragment="single">MFTSGREYNVTQPNSKGEYEIAEGVTSTVFRAVLRYDTALTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q832</accession>
    <name>A0A401Q832_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026783">
        <property type="protein sequence ID" value="GCB81535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="WDRRRWG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="636" mass="76129" checksum="EBDD623317E9E7AD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9V9</accession>
    <name>A0A401Q9V9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019303">
        <property type="protein sequence ID" value="GCB82146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9V9"/>
    <dbReference type="STRING" id="75743.A0A401Q9V9"/>
    <dbReference type="OMA" id="CECTLAY"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000040">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052155">
        <property type="entry name" value="Biofilm_reg_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44757:SF2">
        <property type="entry name" value="BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44757">
        <property type="entry name" value="DIGUANYLATE CYCLASE DGCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="272" mass="30830" checksum="6F80476EEB4B2AAB" modified="2019-05-08" version="1" fragment="single">VLLVFAKEDSQSTGFCWACDRAGYKCNVVRTPEAALECFLDKNHEIIVIDQRHSTYFDAETLCRSIRATKSSENAVVVAVAKRPQGNQEENSVRPLIAAGFTRWYIENPSIIACYNELIQLEFGEVRAQFKLRASSTIFTALEQSQESIEITNEDNIIQYVNPTFEVMMGYQREELIGKELTEVPKSDKNKADLLDTINSYIKKGKEWQGMYYGRKRNGDSIQQNVKITPVIGQGGKIRHYVSIKRPCNENKADKSQLCDRVQAESQTGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QA29</accession>
    <name>A0A401QA29_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024632">
        <property type="protein sequence ID" value="GCB82222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QA29"/>
    <dbReference type="STRING" id="75743.A0A401QA29"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF19">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE HHAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="12015" checksum="6AFEA440943D312E" modified="2019-05-08" version="1" fragment="single">DVADFEWVMWFTKFRNYILFALSGHVLFGKAVSMAAPQHRSLYFMTYGILAVLATMGTSYLVLILAHCILLYSVALAKQKWLCFVAGLCNLATFKIEPVSSWQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC26</accession>
    <name>A0A401QC26_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0023699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01032685">
        <property type="protein sequence ID" value="GCB82931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC26"/>
    <dbReference type="STRING" id="75743.A0A401QC26"/>
    <dbReference type="OMA" id="CKEGQWV"/>
    <dbReference type="OrthoDB" id="431034at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000022">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF31">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB82931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="112" mass="12682" checksum="75E7797DC1E7C790" modified="2019-05-08" version="1">MCLLYQVCKYDYVEVHSGLSSDSKLHGRFCGPETPGIITSQFNNMRIEFKSDNTVSKKGFKGHFFSDKDECSVDNGRCQQQCLNTLGSYVCQCRHGFALHENGLDCKEGQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCY5</accession>
    <name>A0A401QCY5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0023435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029343">
        <property type="protein sequence ID" value="GCB83241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCY5"/>
    <dbReference type="STRING" id="75743.A0A401QCY5"/>
    <dbReference type="OMA" id="FIAFIPH"/>
    <dbReference type="OrthoDB" id="8672326at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB83241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12652" checksum="D21BC4B962A9641D" modified="2019-05-08" version="1" fragment="single">LLRKHPELPLSFSGRFLNVYQPLQLGGIKEPLPYHNDQLRFTGFTGCIRNLIVDSKVYDLANPAEFLDSAPGCAVTDGVCHSAGTFSCGIQGKCLGEWGSFSCDCKPGYTGYKCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDP8</accession>
    <name>A0A401QDP8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0024340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01043776">
        <property type="protein sequence ID" value="GCB83483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDP8"/>
    <dbReference type="STRING" id="75743.A0A401QDP8"/>
    <dbReference type="OMA" id="NQMAREW"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB83483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16658" checksum="0FFBF00072EC822A" modified="2019-05-08" version="1">MALKQINKELQDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNSNSNGSICVDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE00</accession>
    <name>A0A401QE00_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01045245">
        <property type="protein sequence ID" value="GCB83547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE00"/>
    <dbReference type="STRING" id="75743.A0A401QE00"/>
    <dbReference type="OMA" id="DMMEQTK"/>
    <dbReference type="OrthoDB" id="10258312at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="51" mass="5921" checksum="0470ADB36EEBD760" modified="2019-05-08" version="1" fragment="single">LAIQLDENEALKTALQSTLKAKEEDLKLYYDTMGQVKQVFLQALRQHKEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEH9</accession>
    <name>A0A401QEH9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GOLGA6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01045867">
        <property type="protein sequence ID" value="GCB83763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEH9"/>
    <dbReference type="STRING" id="75743.A0A401QEH9"/>
    <dbReference type="OMA" id="HARGGWI"/>
    <dbReference type="OrthoDB" id="8886319at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026737">
        <property type="entry name" value="GOLGA6L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23143:SF30">
        <property type="entry name" value="SPERMATID ASSOCIATED LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23143">
        <property type="entry name" value="TRICHOHYALIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12831" checksum="F3A9CD25AA94EA75" modified="2019-05-08" version="1">MNREGIDEQREGIDEQREGIDEQRGDIDEQREGIDEQREGIDEQREGIDEQRGDIDEQRGDIDEQREGIDEQRGDIDEQRGDNDEQRGGIDEQRGDNDEQRGGIDEQRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QES5</accession>
    <name>A0A401QES5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01056279">
        <property type="protein sequence ID" value="GCB83889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QES5"/>
    <dbReference type="STRING" id="75743.A0A401QES5"/>
    <dbReference type="OMA" id="VHETRNQ"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="27084" checksum="583B9BCA3023069B" modified="2019-05-08" version="1">MGRESRNTGRERRNREGEQEHGEREQEQREREQEHSEREQEHGEVEQKHGVREQEHRKREQEHREREQEHGEREQEQGEREQEHGEREQEHSEREKDHGEGEQEHGEREQEQREREQEHGEREQEHGERDQEQREREQEHGEREQEQREREQEMREREQEHREREQEHREREREPGVREQEDRERAQEHGEREAGIWGERAGTQGERAGTQGERAGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QET8</accession>
    <name>A0A401QET8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01056113">
        <property type="protein sequence ID" value="GCB83873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QET8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="163" mass="18731" checksum="A737667FF984342E" modified="2019-05-08" version="1">MLIDDAFVLIEDYSLLIEDPLFLIEDALMLITNPLMFTEDALLLIIDALLTEDHLLLIEDALLLFEDALLLIEDTLMLIADPLMLIEHPLMLIEESLLLIEDALLLIEDHLMLIDDPFLLIEDYSLLIEDALLLIEDSLMLIDDSLMLIDDRFLLIEDPMMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFJ8</accession>
    <name>A0A401QFJ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TBC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01057218">
        <property type="protein sequence ID" value="GCB84134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFJ8"/>
    <dbReference type="STRING" id="75743.A0A401QFJ8"/>
    <dbReference type="OrthoDB" id="73307at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045799">
        <property type="entry name" value="TBC1D23_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19430">
        <property type="entry name" value="TBC1D23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TBC1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10332" checksum="98705CAF3B92FD02" modified="2019-05-08" version="1">MSTGTLLLRALYLDEIDSSSMSDDDRKEMVNIQTWVNKPDIKHHFPCSEVKETGHMFPRCVMANLQVQLYFRHLQSRVALLKKGIEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGH2</accession>
    <name>A0A401QGH2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0025044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="BFAA01068924">
        <property type="protein sequence ID" value="GCB84470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGH2"/>
    <dbReference type="STRING" id="75743.A0A401QGH2"/>
    <dbReference type="OMA" id="KHFLFEY"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB84470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="108" mass="12201" checksum="9A2EC06DDDC03170" modified="2019-05-08" version="1">MGRFTRVQQKDEEKFIEGEDFCLTEVENGGTLCSRKGVNLPEAALDLPAVSEQDVKDLLFGLDHGVDMVFASFIRKAEDVRAIRRVLGERGKQLKIISKIENHEGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHJ5</accession>
    <name>A0A401QHJ5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01107710">
        <property type="protein sequence ID" value="GCB84845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHJ5"/>
    <dbReference type="STRING" id="75743.A0A401QHJ5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="50" mass="5565" checksum="C56D05B7350D718E" modified="2019-05-08" version="1" fragment="single">SFSVKLAETTDPDKKQMLQRINKAVESSLKSLEEAMQQALSSKEIGNRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIB1</accession>
    <name>A0A401QIB1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0025720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01119793">
        <property type="protein sequence ID" value="GCB85129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIB1"/>
    <dbReference type="STRING" id="75743.A0A401QIB1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070837">
        <property type="term" value="P:dehydroascorbic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB85129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9351" checksum="4D3E42A3463231E6" modified="2019-05-08" version="1" fragment="single">LERLRGTSDTDRQIEEMKKEKEEIQKEKTITVMQLFRKSSCRQPIIIALMMHMSQQFSGINAVSDTASPWRLAAPQIEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ39</accession>
    <name>A0A401QJ39_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01151634">
        <property type="protein sequence ID" value="GCB85392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ39"/>
    <dbReference type="STRING" id="75743.A0A401QJ39"/>
    <dbReference type="OMA" id="CPDRCSD"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="388" mass="40718" checksum="02798F5BE16730DA" modified="2019-05-08" version="1" fragment="single">MSPGENTSEDSCEDSCEDSCETSCVDNCVDSCEDSCEDSCEDSCADSCADSCADSCADSCADSCADSCADSYADSYADSYADSYVDSCVDSCVDSCVDSCVDSCVDSCVDSCVDSCVDSCVDSCVDSCEDCCEDSWEDSCEDSWEDSCEDSCIDSCADSCEESCADSCVDSCEDSCADSSKDRCVESSVDSCEDSSEDSCVDSCEDSCEDSCEDSCEDSCEDSCVDSCETSCVDSCVDSCGTSCETSCEDSCEDSCEDSCEDSCEDSCEDSCVDSCMDSCEDTSQDSSEDSCEDSGVDSCEDSCVDSCVDSCEDSCVDSCVDSCVDSCVDSCVDSNVDSWEDCCEGRCMDSCEDSCEDSCVDICVGSSVDSCVDSCVDSNVDSWEDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK49</accession>
    <name>A0A401QK49_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01193337">
        <property type="protein sequence ID" value="GCB85759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK49"/>
    <dbReference type="STRING" id="75743.A0A401QK49"/>
    <dbReference type="OMA" id="MYPDVIP"/>
    <dbReference type="OrthoDB" id="9950536at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="174" mass="17775" checksum="3DB624AFF8978055" modified="2019-05-08" version="1">MFRDSAPRMFGDSIPGMFVDSTTAMFADCTPGMTGDSTLGIFGNRIPGIFADSTPEMLGDSTPGMFGDSAPGMTGDSTPGMTGDSTPGMFADSTPGMFRDSSPGMTGDSTPGMFGDSTRGMTGDTNPGMFGDSTPGMFGDSTLGMTGHSTPGMFGDSTLGMFGDSTRGMTALWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLA2</accession>
    <name>A0A401QLA2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01246623">
        <property type="protein sequence ID" value="GCB86112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLA2"/>
    <dbReference type="OMA" id="TTADHSC"/>
    <dbReference type="OrthoDB" id="10071928at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052671">
        <property type="entry name" value="Acrosomal_SP-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571:SF34">
        <property type="entry name" value="ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571">
        <property type="entry name" value="URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="206" mass="22398" checksum="67F2F0E33A1C6862" modified="2019-05-08" version="1">MQYSAARRNAVGCSAAQYRAVQCSAVQSSTAQSSAVQHSTVQSSAVQRSTEQCSTAQHRAEQRSTEQCSTAQHSTEQYRAVQYSAAQYRAVQCSAVQRSTAQHRAVQYSAAQSSAVQRSTVQCSTAQHSTEQYSAAQHSTEQCSTAQHSTAQHSTAQYSTEQRSTVQSSAVQRSTVQRSTVQRSTVQSSAVQRSTVQRSTEQRSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLC1</accession>
    <name>A0A401QLC1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0026903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIB43A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01256514">
        <property type="protein sequence ID" value="GCB86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLC1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008805">
        <property type="entry name" value="RIB43A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05914">
        <property type="entry name" value="RIB43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="52" mass="6086" checksum="37658EFDD1C00648" modified="2019-05-08" version="1" fragment="single">MKEAQDEAEWDLQRILAARAALALQEKEAEEARRLRQELDTYNNQLAKEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNC9</accession>
    <name>A0A401QNC9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01375137">
        <property type="protein sequence ID" value="GCB86917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNC9"/>
    <dbReference type="STRING" id="75743.A0A401QNC9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="112" mass="12546" checksum="FD5639B23DCA714C" modified="2019-05-08" version="1" fragment="single">PGHHDPDTATQDTTTQTPRPRKQRPRHRDPGNNDPDTATQDTTTKDTTTQDTTTQVTMTQDTTTQDTTTQDTTTQVTMTQDTTTQETMTQDTTTQDTTTQVTMTQDTRLRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNE9</accession>
    <name>A0A401QNE9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01371553">
        <property type="protein sequence ID" value="GCB86930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNE9"/>
    <dbReference type="OMA" id="MGRMWIS"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="21988" checksum="FABAB562F5498671" modified="2019-05-08" version="1" fragment="single">RERERHGERDTERDRERETERERERETETERHRERERNTETERETETERDRERETERETQRQRETENERQRETENERQRMRQRETENERQRERQRERQRERQRERQRERQRDRERDRERYRERDRERDRERETERQRDRERETERERPRERDRERETETERQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNW1</accession>
    <name>A0A401QNW1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01400224">
        <property type="protein sequence ID" value="GCB87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNW1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="162" mass="20130" checksum="97352CA649E286F0" modified="2019-05-08" version="1" fragment="single">ERERKEMKEGERERNETKEDERERNETKEAERERNEMMEGERERNERKECERVRIQTKEGERERKESKEGERERNETMEDERDRNVAKEGERERNEMKAGERERNEGEREQNETKEGERERNETKDVERERYDMKEGERDRNEMKEGKRERNETSEGEREGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPH6</accession>
    <name>A0A401QPH6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01444359">
        <property type="protein sequence ID" value="GCB87284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPH6"/>
    <dbReference type="STRING" id="75743.A0A401QPH6"/>
    <dbReference type="OrthoDB" id="9447832at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16267" checksum="3A8720760459C907" modified="2019-05-08" version="1" fragment="single">TRAPISTKNTRDPISTKTPELRSTPKTPELRSIPKTAELRSTPKTPELRSAPKTPELRSIPKTPELRSAPKIPELRSTPKTPELRSAPKSPELRSAAKPTELRSAPKTPELRSTPKTPELRSTPYTLELRSTPKTPVLISTPKTPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH32</accession>
    <name>A0A401NH32_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004922">
        <property type="protein sequence ID" value="GCB60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH32"/>
    <dbReference type="STRING" id="75743.A0A401NH32"/>
    <dbReference type="OMA" id="RKTCARD"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903898">
        <property type="term" value="P:negative regulation of PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902237">
        <property type="term" value="P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036493">
        <property type="term" value="P:positive regulation of translation in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11902">
        <property type="entry name" value="SH3_Nck2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11903">
        <property type="entry name" value="SH3_Nck2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000110">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000126">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000027">
        <property type="entry name" value="Cytoplasmic protein nck1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035560">
        <property type="entry name" value="Nck2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035561">
        <property type="entry name" value="Nck2_SH3_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF12">
        <property type="entry name" value="CYTOPLASMIC PROTEIN NCK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="219"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35100" checksum="C99878D5880381C5" modified="2019-05-08" version="1">MFLHRWFHTGLGKTKRKTCARDASPTPSTDAEFSSNGGSSDRIYDLNIPAYVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGGYNGQVGWFPSNYVVEEVDEATADSPSFFTSRLGAAVSNGQTTKVLHMVQTLYPFSSVTEEELNFEKGEIMDVIEKPENDPEWWKCQNSKGQIGLVPKNYVVILNDGPAVSSSHAPQICYTGPSSTGKFAGKEWYYGSVTRHLAEMVLNERGIGGDFLVRDSESSPSDLSISLKASGKNKHFKVQLVDGVYCIGQRRFNTMDELVEHYKKAPIFTSERGDKLYLIKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHY8</accession>
    <name>A0A401NHY8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004969">
        <property type="protein sequence ID" value="GCB60484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHY8"/>
    <dbReference type="OMA" id="YDEISVH"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF6">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB60484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="411" mass="45949" checksum="96987AD141A5A21C" modified="2019-05-08" version="1" fragment="single">MAVGMLKEMALRWFTETQAALILQNGRLPEWFHGFVTRKEAESVLRDRDIGHFLIRLSDRAIGYILSYKGADRCRHFVIQQLKNGRYMIDGSIHTHKSLTALIAYYMTEVIQPFGEVLTESCSQDERSSLYDHISFNLPHNPCSEEAESKEPAARRPGGHPQSEEVPRRPPAIPPKKNRILTARRMNSSLESMSSNSEGLDIAPPLPVRTSLVFEEESQEGVIYGRVHKFKSNKKPLPAASGEDCRIKDSSKNPFHSAEANGRKSQPAGQPPYPSVETNGGIYSLAMEPQPIYSDVFEPTHWPSDVVYTEVDLKQRKMGTVPTGSGNNYATIAVPTEQSCQPVEGKHLNLATPPSTPPRLSPNLNHRVKSSSPTHSSQKREASRKLSPTLRPLPQPADFNERTQIKDSSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQQ1</accession>
    <name>A0A401NQQ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005310">
        <property type="protein sequence ID" value="GCB63172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQQ1"/>
    <dbReference type="STRING" id="75743.A0A401NQQ1"/>
    <dbReference type="OMA" id="DRSICVV"/>
    <dbReference type="OrthoDB" id="10036828at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13338">
        <property type="entry name" value="FERM-like_C_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01777">
        <property type="entry name" value="FERM_F1_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.60:FF:000002">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000075">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037827">
        <property type="entry name" value="SNX27_FERM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037835">
        <property type="entry name" value="SNX27_RA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="169"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB63172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="52671" checksum="AE660F5E7EE32386" modified="2019-05-08" version="1" fragment="single">NGVNVEGATHKQVVDLIRAGDRELILTVLSVPQQEADRLDPGDDSSGNIYYDYSEKRAVPISIPGYKHVERNGEKFVVFNIYMAGRQLCSRRFREFTILHQNLKREFSDFHFPKLPRKWPFSLSEQQLDARRRGLEEYLEKVCSISVLGESDVMQEFLADSSESINGLSDVDLRIALPDRNIITVTVKKNSTAEEVYRAAQEHLRMDSITASFFTLFEVVDHFFERKLVPNEFPHKLYIQNYTSAAAGTCLVIRKWLFTMAQEELLNDNDLAVTYFFHQAVEDVKKGRIRVGDKSYQLQKLSEQHKKVMYLNMIRTCEGYNQIVFPHCRCDSRRKGHVMAAISIQHFKLHACTEDGQLENQVIMFEWDEMHQWDTDEEGMAFCFEYIRGEKKPRWVKIFTPYFNYMHECFERVLCELRWRKEVSHQSSALDVVGFVFLAGSDVALCKVHLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQT4</accession>
    <name>A0A401NQT4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0011585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005317">
        <property type="protein sequence ID" value="GCB63225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQT4"/>
    <dbReference type="STRING" id="75743.A0A401NQT4"/>
    <dbReference type="OMA" id="CYPLKYR"/>
    <dbReference type="OrthoDB" id="5959645at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15055">
        <property type="entry name" value="7tmA_TAARs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000030">
        <property type="entry name" value="trace amine-associated receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="46"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB63225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="350" mass="39369" checksum="11C3735D1B87E8FD" modified="2019-05-08" version="1">MNSAHLDNCSTYGNSSGKTPLTIWQTMEHVATFSILAIITVGTTFGNLLIIISIAYFTKLRTPTNAFIMSLAAADFLVGVTVMPFSMSKVVFGWHFGKTFCKVHTIMDVLLCTSSILHLSCIAFDRFYAVCYPLKYRFRMSQRRVTVLLLICWILPVSVSIVPLLLDVNLRGLDLQLEPHGCMFIVNIPYAVSASLVSFFVPMLVMLMAYGKIFQVARMQAKQTCSIGNGFQGNSARTRQSGSMKKERKAAKTLGIIIGCFLLCWLPFFITNIANPLLGYPMHHDLLEVFLWLGYINSTFNPLLYAFFNKSFRRAFCLIMGCKIFTNDCQNNNLSDPTIRRNTQLATLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NR29</accession>
    <name>A0A401NR29_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TRPM SLOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0007372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002656">
        <property type="protein sequence ID" value="GCB63302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NR29"/>
    <dbReference type="STRING" id="75743.A0A401NR29"/>
    <dbReference type="OMA" id="WRGDRED"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF6">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="962"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="11">
        <location>
            <begin position="117"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="12">
        <location>
            <begin position="379"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="750"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB63302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1158" mass="132166" checksum="39BCAD68401C4C65" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NR48</accession>
    <name>A0A401NR48_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006642">
        <property type="protein sequence ID" value="GCB63322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NR48"/>
    <dbReference type="OMA" id="QECGSHH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="209" mass="21785" checksum="B82490AD215A0FEE" modified="2019-05-08" version="1">MVAFLLVAAALEDALQLYELELLKEEEAAAAERAAEERAAAERAAEERAAAERAAEERAAEERAAEERAAEERAAAEGAAAERAAEERAAAKRAAEERAAAERAAAERAAGERAAAKRAAEERAAEEHAAAERAAEERAAAERAAAERAAGERAAEERAAAERAAAERAAAERAAEERAAAERAAAERAAGERAAAKRAAEGQECGSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUB0</accession>
    <name>A0A401NUB0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0013347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006773">
        <property type="protein sequence ID" value="GCB64481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUB0"/>
    <dbReference type="STRING" id="75743.A0A401NUB0"/>
    <dbReference type="OMA" id="CHQKESH"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02339">
        <property type="entry name" value="ZZ_Mind_bomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000044">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000004">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042056">
        <property type="entry name" value="MIB1/2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB64481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19924" checksum="2A5AFEAB24AB60CF" modified="2019-05-08" version="1">MEVGMRIVRGVDWKWGNQDDGEGHVGTVVEIGRQGSTTTPDKTVVVQWDCGTRTNYRTGYQGAYDLLLYDNAQIGVRHPNIICDCCKKHGIMGMRWKCQVCFDYDLCTQCYMINKHDLTHSFERYETAHSQALADEVLRLVEVLEGNDVYGTITQIMEMEGKKKHILFIYLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWQ3</accession>
    <name>A0A401NWQ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal assembly factor 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0004757</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001428">
        <property type="protein sequence ID" value="GCB65301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWQ3"/>
    <dbReference type="STRING" id="75743.A0A401NWQ3"/>
    <dbReference type="OMA" id="ELAAWHF"/>
    <dbReference type="OrthoDB" id="348005at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06469">
        <property type="entry name" value="p23_DYX1C1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000176">
        <property type="entry name" value="dynein assembly factor 4, axonemal isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000015">
        <property type="entry name" value="dynein assembly factor 4, axonemal isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037894">
        <property type="entry name" value="CS_DYX1C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052004">
        <property type="entry name" value="Dynein_assembly_factor_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 4, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492:SF1">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="CS" evidence="13">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="93"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB65301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="427" mass="49182" checksum="73ACF1F1C59D1B7E" modified="2019-05-08" version="1">MPLLVRDYTWDQTETQIFITVPLKGVRAGKADIFCTEDYLKVNFPPFLFEVVLFASIDESKSSAKVGNGVIIFTLYKKESGMWEQLPTVEVSKEKLQKKRENAILAAQNKAQEAATEKAIKKRGNEKYSLEKMMKIEEDNRKQIEEMKEQERRNATKELEEWKLQKHEEEELKRKEELKRKEELKIARHKIEAEKRRMKKEDNKIQNIGSRRPNRHSVNRGTTGNIFAENSKEQIIPSPRSAGNIQIHFTPRVFPTALRESLVDEEEEWLRKQAEARRAENANIANLKDLKEEEKNPDWLKDKGNKLFASGDYLAATNAYNLGIQLNNKLPVLYLNRAACHLKLRNLHKAIEDSSTALDLLTPAVPDNASSRLKAHIRRGAAFCELELYVEGLQDYEAALKIDPSNKTIQEDAEKIRHVIQGTPPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWY4</accession>
    <name>A0A401NWY4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein BRAWNIN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0004777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UQCC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001434">
        <property type="protein sequence ID" value="GCB65388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWY4"/>
    <dbReference type="OMA" id="AVHRYYR"/>
    <dbReference type="OrthoDB" id="6139781at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027858">
        <property type="entry name" value="BRAWNIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28492">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC691921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28492:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14990">
        <property type="entry name" value="DUF4516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB65388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7502" checksum="5C9FBADC09068FAE" modified="2019-05-08" version="1">MPAGVSWPRYLKMLGSSILAMFAGAEVVHRYYRPDLSIPEIPPKPGELKTELLGLKSKVQTHNSEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX36</accession>
    <name>A0A401NX36_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006878">
        <property type="protein sequence ID" value="GCB65420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX36"/>
    <dbReference type="STRING" id="75743.A0A401NX36"/>
    <dbReference type="OMA" id="ISDANQW"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF5">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16625" checksum="8AEA86498A71DD5D" modified="2019-05-08" version="1">MGFDAAINYKQDNIVEKLREYCPAGVDVYFDNVGGDISNTVIGQMNQNSHIILCGQISQYNKDVPYPPPLPPDTKAILKERNIARERFLVLDYSDKHEVGLVLLSQWLKEGKLKVRETVVKGLENIGAAFESMMKGGNIGKQIVLVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXQ9</accession>
    <name>A0A401NXQ9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Arylsulfatase K</fullName>
            <ecNumber evidence="12">3.1.6.1</ecNumber>
            <ecNumber evidence="14">3.1.6.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glucuronate-2-sulfatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0007762</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate. Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.</text>
            <dbReference type="EC" id="3.1.6.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="12"/>
    <dbReference type="EC" id="3.1.6.18" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01002865">
        <property type="protein sequence ID" value="GCB65645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXQ9"/>
    <dbReference type="STRING" id="75743.A0A401NXQ9"/>
    <dbReference type="OMA" id="TKAVMIR"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015024">
        <property type="term" value="F:glucuronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000039">
        <property type="entry name" value="arylsulfatase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051849">
        <property type="entry name" value="GAG-degrading_sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46615">
        <property type="entry name" value="ARYLSULFATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46615:SF1">
        <property type="entry name" value="ARYLSULFATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018984451" description="Arylsulfatase K" evidence="19">
        <location>
            <begin position="30"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="20">
        <location>
            <begin position="48"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB65645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="548" mass="62289" checksum="71DA44AC3AEA0DE2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYL5</accession>
    <name>A0A401NYL5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0000516</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000095">
        <property type="protein sequence ID" value="GCB65961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYL5"/>
    <dbReference type="STRING" id="75743.A0A401NYL5"/>
    <dbReference type="OMA" id="ANAKRYC"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF236">
        <property type="entry name" value="PROTOCADHERIN GAMMA-C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019371254" description="Cadherin domain-containing protein" evidence="10">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB65961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="296" mass="32399" checksum="314494AEF62B439A" modified="2019-05-08" version="1">MADSQSNNAWKFMVMVFVELICAVDVVSAQIRYSVPEEMEQGAVIGNIAEDLGLNLATLSGRKGRLVADYTKRYLEVNLENGLLLANERIDRDKLCGPITTCVLSFQIVFENSPEMYRGEVEIVDINDNSPSFPESVVLLRMAESMAPGSSFPLESALDPDVGKNAVSVYNISPNEHFCLKVKFVDDGTKIVQLLLEKPLDRERQSSFQLMLTATDGGSPSRSGTARILITVLDSNDNAPTFAREIYKVSLIENSPRGTLVVSVHATDLDEGSNAEVRDTCGKGTAVSMAEFNLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYQ9</accession>
    <name>A0A401NYQ9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006948">
        <property type="protein sequence ID" value="GCB66042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYQ9"/>
    <dbReference type="STRING" id="75743.A0A401NYQ9"/>
    <dbReference type="OMA" id="HHNDECY"/>
    <dbReference type="OrthoDB" id="9442762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="217" mass="25095" checksum="E563DAC3B89A3D75" modified="2019-05-08" version="1" fragment="single">RHPPLNTTTRVPYILDVQYPPTTTLLSTTVPPIYSTAGITSLSTFTQRLPIPPKNMESVKSDSLGTIIGGVVGGTLFLMLVVIIIIMFYLRHRRTFRGDYYTKQFTGAADIQKDSQMDVLQSNRIEPYTDYEKSEQKLEPNNIFQDYPIEVQKSKWQSEDNINNRYTEGVEIPVDCYEDRKIPNAPQYLHDDYYDENEDDLVSHLDGSIISRREWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ63</accession>
    <name>A0A401NZ63_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec16 Sec23-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0004922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001485">
        <property type="protein sequence ID" value="GCB66178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ63"/>
    <dbReference type="STRING" id="75743.A0A401NZ63"/>
    <dbReference type="OMA" id="GNPQIPM"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF13">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="7">
        <location>
            <begin position="127"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="758" mass="83444" checksum="4B303364726F8945" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZM3</accession>
    <name>A0A401NZM3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005652">
        <property type="protein sequence ID" value="GCB66304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZM3"/>
    <dbReference type="STRING" id="75743.A0A401NZM3"/>
    <dbReference type="OMA" id="VRFFESF"/>
    <dbReference type="OrthoDB" id="437530at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF46">
        <property type="entry name" value="HOMEODOMAIN-INTERACTING PROTEIN KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB66304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="375" mass="43594" checksum="26AB2AF805BA4EB5" modified="2019-05-08" version="1">MLRMLGSVDSDRFHIVRFFESFNDDTKLCLVFELLEQSLYEYQKDNSFLPLPIRHIRSITKQLLIALQKLKELSIVHTDIKPENIMLVEQAQFPFKVKVIDFGSACILSEIQQIKGPYIQSRFYRSPEILLGLPFCEKLDMWSLGCVMAELHLGWPLYPGTNEYDQIRYIVEMQGLPSDHLLEVASKTHHFFKKARQPNSTYQWTLKTVDEYQAETMVQPLETRTKTMHSLDHLVAINSSKTMFPDRELKAELFDQQTMVALIKKILTFDPGQRIAPNVAIKHPFLTMQKLKSKYKHTKYYEASSQALGAALRYEENEKEKQVVCCQRFKQSCYFSNETYEQVFSQQKSQITNKQTDTENVDGAADNEFGKQVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0F5</accession>
    <name>A0A401P0F5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0010125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004302">
        <property type="protein sequence ID" value="GCB66615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0F5"/>
    <dbReference type="STRING" id="75743.A0A401P0F5"/>
    <dbReference type="OMA" id="PNAVRNT"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14516">
        <property type="entry name" value="1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14516:SF3">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="310"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="489" mass="54357" checksum="FAF91CC6313237F3" modified="2019-05-08" version="1">MLGLRRLLLKSRFGLRLQHTAPIAVKNEPVFDFKQGSSERQALDKALHDLKGKTLEVPCVVGGEHVWTKDIQYQLCPFNHSHKVAKFCYADKDLINKAINAALSAHREWDLKPVEDRAQIFYKAADLISGLRRAELLARTMFGQGKTVIQAEIDAAAELIDFFRFNAKYAVELQHEQPISEPPSTNSTLYRSLEGFVAAVSPFNFTAIGGNLAGAPALMGNVVVWKPSDTAMAASYTVYKILLEAGLPPNVIQFVPSNGPVFGDTITESEHLAGINFTGSVPTFKTLWKLVSEKLDKYRTFPRLIGVDDFETFFSAVIDDKSFARIKKWIEHAQSSPNLTIIAGGKCDDKTGYYVEPSIIESKDPHDPIMREEIFGPVIAIYVYPDNKYQEILHLIDTSTPFGLTGAVFAQDKNVVAEACKVLRYSAGNFYINDKSTGSVVAQQPFGGARISGTNDKAGGPHYILRWTSPQSVKETHTPLTKWKYPYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0H2</accession>
    <name>A0A401P0H2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calx-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0013597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FRAS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007017">
        <property type="protein sequence ID" value="GCB66619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P0H2"/>
    <dbReference type="OMA" id="RHGYLFN"/>
    <dbReference type="OrthoDB" id="430044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000008">
        <property type="entry name" value="FRAS1-related extracellular matrix protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045658">
        <property type="entry name" value="FRAS1-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF15">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 3 PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19309">
        <property type="entry name" value="Frem_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019054496" description="Calx-beta domain-containing protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="335"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="454"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="563"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="700"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="827"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="944"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1188"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1420"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1532"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1655"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="10">
        <location>
            <begin position="1753"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="10">
        <location>
            <begin position="1871"/>
            <end position="1982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB66619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2008" mass="224002" checksum="EC497B3205C8BEC9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0X5</accession>
    <name>A0A401P0X5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005705">
        <property type="protein sequence ID" value="GCB66785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0X5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="44" mass="4416" checksum="48733607EC26C445" modified="2019-05-08" version="1" fragment="single">GGWAGPGDGRGLANGQRSRRRSQGAGAEGLTGAAVFQVPKIIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P145</accession>
    <name>A0A401P145_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Collagen alpha-1(XXI) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0010158</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004324">
        <property type="protein sequence ID" value="GCB66856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P145"/>
    <dbReference type="STRING" id="75743.A0A401P145"/>
    <dbReference type="OMA" id="WLVNISN"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000068">
        <property type="entry name" value="collagen alpha-1(XXI) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000041">
        <property type="entry name" value="Collagen alpha-1(XXI) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF90">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXI) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019166093" description="Collagen alpha-1(XXI) chain" evidence="14">
        <location>
            <begin position="17"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="31"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB66856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="491" mass="54445" checksum="07C0B0CB2D601E92" modified="2019-05-08" version="1">MFLIFLLLLLQELSAAVEDDVRSSCRTAPNDLVFILDGSFSVGPKDFEIVKNWIVNISSSFEIGTTFTKVGVIQYSDHPLLEIALDKHRSNEDLMKAMDAILYRGGNTRTGKAITFGVNNVFATSTRAANAVTKVAIVLTDGKSQDDVKHSAEEARRNKIILFAIGVGQEIEDAELQAIANKPSSTYVFHVKDYTGISRIREIMKQKLCEETVCPTRIPVASRDEKGFDILVGLDIRKKASKIQGSYSRKKAYSVTPQSDLTDKTRDIFPDGLPPSYVFVSTLRLKRPATKEKWDLWRILALDGTIQTAITLNGEDNTVVFYTTHMMNETQSVTFTSPLIKALFDENWHLLRVLVTERDVTLYLDDKLVETRQLEPVLGIFVSGRTQIGKYFGKEATVPFEVQKLRIYCDPEQNQRENACEIPAVCDSSLDDVSSTPPPCTCTPGPAGPQGLKGEHGAPGEHGNPGSPGADGKPVSTKWFTHLYLKNLCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P161</accession>
    <name>A0A401P161_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Heat shock factor protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Heat shock transcription factor 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0012061</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-binding transcription factor that is essential for male fertility, spermatogenesis and meiotic prophase progression in spermatocytes under non-stress conditions. Positvely and negatively regulates gene expression to ensure progression of meiotic prophase beyond pachytene stage in spermatocytes. Plays a role in male germline meiotic sex chromosome remodeling and silencing through regulation of SMARCA4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005711">
        <property type="protein sequence ID" value="GCB66851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P161"/>
    <dbReference type="STRING" id="75743.A0A401P161"/>
    <dbReference type="OMA" id="VVSHEME"/>
    <dbReference type="OrthoDB" id="6418155at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000531">
        <property type="entry name" value="Heat shock transcription factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF278">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="20">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB66851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="417" mass="46545" checksum="43D0EE295E555C25" modified="2019-05-08" version="1">MSPVVSHEMEEFLLSTPINPNNFPAKLWRIVNSPRYRSIRWDPRGEGLIVDQQLFESELLTPIKNVSNGANLEPDTDLLFKTTNFTSFIRQLNLYGFRKMGQGSGEHPVPGELGAGDGLLHHFHNPSFKQDHPELLINMKRLTSANKAKLAAGLQVNTRPPNRFQRYLTNSMDSIGQTKGDRHGPVTVGQLQRTFRRDSLSPYPFMSPSHNQSPLHTVSIKSLSSSNTGGLDRTPIPPRTWHSSIGLVAGQMDTSSSSPFSDKAIPFSVIQRFPTEVTYTLQPNPNNVHVQQGTQEIGATGQKYTGYLTSPQYHQAFYPTAVLQCCPPNSHLDPMTGCPNTNTSSYPNYNYYQVRLLSKDSAIYEVLAQKCPEQHIESEKASWNSHTHALDGKEEQMTGNTRLTDIEQSNIEALGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1C0</accession>
    <name>A0A401P1C0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005716">
        <property type="protein sequence ID" value="GCB66911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1C0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB66911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="65" mass="7156" checksum="3C767FAC7C7FB012" modified="2019-05-08" version="1" fragment="single">LNNHFNSSDHQVLNQRKVLTIEESSHGSCVKLGSLYSVIKVVNATQKESTEDLTGDNRIKTENAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2Y8</accession>
    <name>A0A401P2Y8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007118">
        <property type="protein sequence ID" value="GCB67515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2Y8"/>
    <dbReference type="STRING" id="75743.A0A401P2Y8"/>
    <dbReference type="OMA" id="DTDHVGQ"/>
    <dbReference type="OrthoDB" id="8964506at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.180">
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="287" mass="31484" checksum="A2651B324935E83D" modified="2019-05-08" version="1">MVDMDSIGQKDMDHVGQLDTDHVGQLDTNHVGQVDKDHAVQVDMEHVDLVDADSIDMVDKDHNGQLDKDHVGQVVQNHVGQVDTDYVDHVGQVDTDHVGQVDTDHVGQVDTDHVGQVDTDHVGQVDTDYVGQVDTDYVGQVDTDCVGQVDTDHVGQVDMDNVGQVDTDYVGQVDTDHVGQVDMDYVGQVETDHVGQVDMDYVGQVDTDYVGQVDTDYVGQVDTDYVGQVETDHVGQVDMDYVGQVDTDHVGQVDMDHVGQVDTDHVGQVDMDYVGQVGTIMLARWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3H3</accession>
    <name>A0A401P3H3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0012173</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005796">
        <property type="protein sequence ID" value="GCB67661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3H3"/>
    <dbReference type="STRING" id="75743.A0A401P3H3"/>
    <dbReference type="OMA" id="TMVRVCE"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000012">
        <property type="entry name" value="protein tyrosine phosphatase type IVA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB67661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="173" mass="19575" checksum="8F35F11D10C6DD8C" modified="2019-05-08" version="1">MARMNRPAPVEVSYKHMRFLITHNPTNATLGAFIEELHKYGVTTVVRVCDATYDKSPVENEGIEVIDWPFDDGDPPPSKIVEDWLNLLKTKFTEQPGCCVAVHCVAGLGRAPVLVAVALIESGMKYEDAIQFIRQKRRGAINSKQLLYLEKYRPKMRLRIKAHNNHKNSCAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3S0</accession>
    <name>A0A401P3S0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger and BTB domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0000767</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000158">
        <property type="protein sequence ID" value="GCB67768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3S0"/>
    <dbReference type="STRING" id="75743.A0A401P3S0"/>
    <dbReference type="OMA" id="IEMVAGI"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF15">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB67768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54756" checksum="211D3A1C919E7B9E" modified="2019-05-08" version="1">MEQIEYMLSSTMDLSTNYFHVEFPNFTNTLLQKLNQQRQEGQLCDIAIQVQGHLFRAHKAVLAATSPYFCDQVLLKNSNRILLPDIMNPKAFENVLLFCYTGKLVLPATDIVSYLTVASFLQMWHVVDKCTELLKVRPAVHFQKSNHLNDHQSPSSSNFNGSVEPSEVGAMGQPEFHKTVNGDSKAEENGSEGSPKEDDMSPPQLMDHDNLPSNSSGEHDNLSTEMNSQDGEEGASDTAEYPYSRPIYSQPSIMPHKRWVYVKQEKFEQDYGDGTIHPTAEEQRVSESENITQAEPVIQSSSIDDSFNIVAAKTQEIFKEGREHSSYDEQADYYGSSVDEFSADRGDINVTGHHQDPLTAAEMQVNRLPGYGIEPELGTGVSEKTTQSGFTAVVYKLYPCQCGKNFTHKSQRDRHMSMHLGLRPYGCGVCGKKFKMKHHLVGHMKIHTGIKPYECHICGKKFMWRDSFHRHVTSCTKLYQIPDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4Y1</accession>
    <name>A0A401P4Y1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0008185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003086">
        <property type="protein sequence ID" value="GCB68168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4Y1"/>
    <dbReference type="STRING" id="75743.A0A401P4Y1"/>
    <dbReference type="OMA" id="PLHTCIP"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000037">
        <property type="entry name" value="C-type lectin domain family 18 member A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019149963" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="218"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB68168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39698" checksum="7C1373A440A8DFC6" modified="2019-05-08" version="1">MNGAAVLPVLLASLALAAADTEPGKGTLHWGLKELTPKEGFAILAHHNRLRSKVQPPAANMQKMLVWATSSEIGCGKRTCFQNGEWIDVVICAYSPGGNWEINGRTIIPYKEGPSCSLCTSRMSGCFKSWDHHGGLCEVPRNPCRMSCSNRGQLNVSSCRCECLPGFTGRYCQVRCSLQCIHGRYKEEECSCMCDVGFGGALCGEKMEFPFHTCDTRIDGDCFMVSPEADTYYGAKNKCQERGGILAQVKNQKVQDIMAFYLTQLENTNEVTDPDFETRNFWIGLTYKTSRDSFRWDSGELPTFSSFAFGQPDNQGFGNCVELQLSSAFNWNDQRCKTRNRYICQFSEKHVAQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5B7</accession>
    <name>A0A401P5B7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0000867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000178">
        <property type="protein sequence ID" value="GCB68341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5B7"/>
    <dbReference type="OMA" id="VETTNDH"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12472">
        <property type="entry name" value="RRM1_RBMS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12475">
        <property type="entry name" value="RRM2_RBMS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000014">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034406">
        <property type="entry name" value="RBMS3_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="139"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB68341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="420" mass="45849" checksum="CB0E3F64787E6C29" modified="2019-05-08" version="1">MGKRLEQQPMYPQYTYYYPHYLHTKQSYAPAPHPMAPPSPSTNSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKASGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKMPPGVPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGETGMALTYDPTAAMQNGFYSSPYSIATNRMIAQTSITPFIAASPVSTYQVQSTSWMPHQPYVMQPAGAVITPTMDHTMSMQPASMMGPLTQQMNHLSLGTAGTYMTAAAPMQGTYIPQYTPVPPAAVPVEGVVADTSPQTVAPSSQEASGQQQQIPVETTNDHAPTYSYQQAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6R6</accession>
    <name>A0A401P6R6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003142">
        <property type="protein sequence ID" value="GCB68831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6R6"/>
    <dbReference type="STRING" id="75743.A0A401P6R6"/>
    <dbReference type="OMA" id="REYYATV"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02649">
        <property type="entry name" value="nuc_hydro_CeIAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="325" mass="35882" checksum="704DCE70A53450E4" modified="2019-05-08" version="1">MTDSKMANKKLLLLDVDCGVDDAQAMMMALAAPNVQILGITCCHGNTTIDNVCRNVLRVLKVCRGTEIPVFRGACRSLLGQTLNASDYHGKDGLGDVPDPNSPGLEHVQTEHAVNAMIRIVTEHTGQISLVAVGPLTNVALAIKMDPTFSTKLKHLYIMGGNMEGRGNTTICGEFNFVSDPEAASIVLNQFACPIYIATWEYTKRHFLPWGFFHEWINQGTEKACFMKAITENSVKRMKIKQSDKEVHRREGFVSCDSFAVAAAIDGSVVTEYMQCGVSVELQGELTRGMMVLDTLNLQKKQNRAFIMVKCDLEKLKQLMMSALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7S1</accession>
    <name>A0A401P7S1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0013929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007308">
        <property type="protein sequence ID" value="GCB69162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7S1"/>
    <dbReference type="STRING" id="75743.A0A401P7S1"/>
    <dbReference type="OMA" id="VKRNKMG"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08033">
        <property type="entry name" value="LARP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000158">
        <property type="entry name" value="La ribonucleoprotein domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF61">
        <property type="entry name" value="LA RIBONUCLEOPROTEIN DOMAIN FAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="72"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="7">
        <location>
            <begin position="415"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB69162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="484" mass="54372" checksum="EFC00D15DF4E2F00" modified="2019-05-08" version="1" fragment="single">FAMSSSDSPVSWLGSPASCSSPVQVRGQGRPSRIRKRIGSEDAEEFHCNSDQHNSCDPSETNDECLEYNEWIPPNSDKIQKIIAQVEFYLSDENLAVDSFLLKHMKKNKMGYISIKLLTSFKKVKCLTKDWKVTAYALNYSKLLEINQEGTKIRRKNPVPEFLLSVPPSKRILAWDLYKDSPGNNSEIHGHVNIMETAMKIFSVHGPISSIRILQPGREIPAELKKYTLKYPEVGTKICILVEYEYYEGAKKAYEELGKKHCHNGENLKVVILTGKGTKKINSIDTDESDDLKKSNPKKPPKRPAKIEQMQCTMGEFIYSSSESDGANSPAYVQRYLQHKICDAYNCNSQISSTTSLSQSWSDHYCGQCISRRSLVYHHPSPLADFVAQGVWPSPGTSPEFTKKFHDHLSDSGNCSGSPWVQRRKLAANQATSLEINQTTYKQLVRKHQSGTGLPSGLVRLPFGPDGTKGFHNSIGRGRIVLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8B8</accession>
    <name>A0A401P8B8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001701">
        <property type="protein sequence ID" value="GCB69352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8B8"/>
    <dbReference type="STRING" id="75743.A0A401P8B8"/>
    <dbReference type="OMA" id="AMCHIRR"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="11">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB69352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="196" mass="22928" checksum="0DCA548CE4A66239" modified="2019-05-08" version="1">MFCEKAIELIRELQRAADGQLPAFNEDGIRQVLEEMKALYEQNQTDVNEAKSDGRTDLIPTIKFRHCCLLRNKRCVLAYLYDRLLRIRSLRWEYGSVLPSGIRFHFAAEETEWFNQYKKSLATYMRSIGGEGGLDITQDMKPPKSLFIEVRCLKDYGEYEIDDGTTVLLKKNSQHFMPRWKCEQLIRQGVLEHVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P938</accession>
    <name>A0A401P938_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0008419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003217">
        <property type="protein sequence ID" value="GCB69622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P938"/>
    <dbReference type="STRING" id="75743.A0A401P938"/>
    <dbReference type="OMA" id="NQHRYIE"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000030">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="144"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB69622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="317" mass="35627" checksum="9C9504C5EF17A6FF" modified="2019-05-08" version="1">MSKCKEDGSYTPTVAIVRIPDSEDACDSEPEVAGGGPRDHRAPRGRRMLIFLDMICIVLASLPFFMVEFNGVTPYRRGFYCDDESISYPHKEEETISDPVLCTAGILITVIAIVVGESYRVRFLNEQSKSFVSNPYVSMIYKQAGSFLFGCAVSQSLTDLAKVAVGRLRPHFLDVCRPDFTKINCSQGYIEDYDCSATPSAETEARKSFYSGHASFAMYTLLYLAFYLEARFTWKGARLLRPLLQSLLVMMAFYTGLSRVSDYRHHPSDVLVGFLQGVIIAYWIAFHISEMFKSKKQTVKESNVCADNSIQTNHTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PA42</accession>
    <name>A0A401PA42_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0001167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000252">
        <property type="protein sequence ID" value="GCB69988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PA42"/>
    <dbReference type="STRING" id="75743.A0A401PA42"/>
    <dbReference type="OMA" id="YPMHQSV"/>
    <dbReference type="OrthoDB" id="1585644at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000073">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="10">
        <location>
            <begin position="244"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="480" mass="54676" checksum="D519E5345F09EAEC" modified="2019-05-08" version="1">MTGEKAERITNGRSARRDHRLFKEEAEQDDEAARTKNRTKLFANHKLIKSPAFTTDATATRGEDFPVHECVFKGDIRRLSSSIRTHNIAQKDLHGNTPLHLAVMLGHKECAHLLLAHNAVVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRENVEEKRPRLLKALKELGDFYLELHWDFQSWVPLLSRILPSDACKIYKQGINISFTLRSRSTQGNGHKSMSSLYLPLPTTENHGTFCGTQESEMETEEEVDILMSSDIYSATLSTKSITFTRAQTGWLFREDKTERVGNFLADFYSVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNLMEQNFEPVRRQSLSPPPANTITWEEYISAESGKAPHLGRELVCKESKKTFKATIAMSQEFPLGIDSLLNVLEVIAPFKHFNKLREFVQMKLPPGFPVKLDIPVFPTITATVTFQEFRYDGFNDSIFNIPSDYNEDPSRFPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAW2</accession>
    <name>A0A401PAW2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006106">
        <property type="protein sequence ID" value="GCB70255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAW2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="34" mass="3821" checksum="C96BB6C56C33C55D" modified="2019-05-08" version="1" fragment="single">TQQSTNAESRIDPPEAKTPLRQATPSFQSPFYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB55</accession>
    <name>A0A401PB55_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000274">
        <property type="protein sequence ID" value="GCB70352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB55"/>
    <dbReference type="OrthoDB" id="6107088at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="216" mass="24554" checksum="62956B46A9F2DBFD" modified="2019-05-08" version="1">MQNKQPHQDASARNMTGIYLGMQGSPLKFTHISAVPPLFRRRSLERAKTSVEYQRYKKIEMLRLVETRPGFKGAVVKPKVKSVSPEVELHPHYHSKSPLLTAEQLRSLTRRVLRDFAIPEQSNGDMSGRRSKSSGLLNSPRKPPNSSRQSNIQGLSIVMNPGRTDDPYRVTLAKQELMRTKPGYQEVCESTVPFHPERSNHNRQLRSSGAHHLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD89</accession>
    <name>A0A401PD89_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase NUDT19</fullName>
            <ecNumber evidence="11">3.6.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nucleoside diphosphate-linked moiety X motif 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">scyTo_0010928</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates. Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(6Z)-octenoyl-CoA + H2O = S-(6Z-octenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67528"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:172383"/>
            <dbReference type="ChEBI" id="CHEBI:172384"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:67529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67540"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:172388"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:67541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-tetradecenoyl-CoA + H2O = S-(9Z-tetradecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65060"/>
            <dbReference type="ChEBI" id="CHEBI:172389"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:67545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67536"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:172387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:74034"/>
            <dbReference type="ChEBI" id="CHEBI:172386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:67533"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67524"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:172385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:67525"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="3.6.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:64989"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67592"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="Rhea" id="RHEA-COMP:17276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
            <dbReference type="ChEBI" id="CHEBI:172371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:67593"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:50045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:49976"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132011"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:49977"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>choloyl-CoA + H2O = S-choloyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132020"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:50037"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132015"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:50025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:50033"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexanoyl-CoA + H2O = hexanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:49980"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
            <dbReference type="ChEBI" id="CHEBI:132012"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:49981"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>malonyl-CoA + H2O = malonyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:172363"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132013"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:50017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67464"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:172362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:67465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>succinyl-CoA + H2O = succinyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67472"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:172364"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:67473"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50028"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132017"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:50029"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.77" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01004817">
        <property type="protein sequence ID" value="GCB71093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD89"/>
    <dbReference type="STRING" id="75743.A0A401PD89"/>
    <dbReference type="OMA" id="GFMPSAH"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="31">
        <location>
            <begin position="70"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="GCB71093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="422" mass="49431" checksum="B82A2F94D02AED5F" modified="2019-05-08" version="1">MRVRLWIRWLKLNTQTTYFHLYNIKLCITPSTTRNKMNRDLRYWKEAATVILAAGVRNNFVNTSATSTQTCRPPISVPKRERTLTHSRLETALFDYTVLMLQRSAKSSFMPNAWVFPGGTVDPSDFSSEWIQIFQPLCEPPNFKIGTVRQPPKRPPILAMDRRKLGSEIPGEVAFRICAIRETFEESGILLVKPNAPDKCLKSQEALQYDQKELAIWRPLLQKNAENFMKLCRELDCIPNIWALKEWSNWLTPTYPKGKRFDTVFFICCLQEIPFTLHDDRETIQHNWMSPLDFIEGYNSGKFYVPPPQWHELGRLCRLPYLQELQRFSQDRALDGCERWFPIRLVASDGFATLYPGDELYPEDPDYTGEREMDICSSKTLEQLRLEVTRLHRIELRDRHAIALYVNIEPPYKHVHPLTMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDC4</accession>
    <name>A0A401PDC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0008769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01003412">
        <property type="protein sequence ID" value="GCB71115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDC4"/>
    <dbReference type="STRING" id="75743.A0A401PDC4"/>
    <dbReference type="OMA" id="CVIYDMM"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05575">
        <property type="entry name" value="STKc_SGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000065">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000030">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="188"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB71115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="521" mass="58857" checksum="42E32C297F67C7E5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE23</accession>
    <name>A0A401PE23_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0005915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001918">
        <property type="protein sequence ID" value="GCB71359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE23"/>
    <dbReference type="STRING" id="75743.A0A401PE23"/>
    <dbReference type="OrthoDB" id="2142729at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB71359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="11200" checksum="E72DFCEE800759EF" modified="2019-05-08" version="1">MLYDIDFDLYLENHKTWLASKKFQNNRDDPAYCVEELEIQTINKEFAGKQRIFQQSMAQIVIELALVNQHKGSLVQQLNEQEKSLHQIPLESQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE99</accession>
    <name>A0A401PE99_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hsp90 co-chaperone Cdc37-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003466">
        <property type="protein sequence ID" value="GCB71428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE99"/>
    <dbReference type="STRING" id="75743.A0A401PE99"/>
    <dbReference type="OMA" id="EFWELKQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF2">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="129"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="296"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="367" mass="43420" checksum="1F20A090055F5793" modified="2019-05-08" version="1">MMDYRPGFPAAASDNDDEEEAADEEEGQRYKLFPNMACQSQVHMGGVESVCHKQQELVKRTMECRWRLAEAQQRLCDLELHNSESLEQERAKAQTEFWELKQKEDEWRQKEEELIWNERLSSWNIDTDSKEGFNKSVINKKIKCKEVEEDGKNVTFAQKYNQQIRHFGMLKRWVDSQRYLSDHPHLICQETANYLIKWCFHLKEEEKQALMEQVAHQAVVMQFIIELGRSLQEDPRGCFRQFFEKAKVAEEGYMEAFNTELAEFIQRVRDFAEAKTAETITIHNVARHLNHLDVHRLPPMEVFESLPQELKRCFQLKDVHVLQNMLSNMNPQVAEHYLQCCIDAGLRIYNTKEAKEERNEEPNMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFG4</accession>
    <name>A0A401PFG4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fanconi anemia group B protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000399">
        <property type="protein sequence ID" value="GCB71861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFG4"/>
    <dbReference type="STRING" id="75743.A0A401PFG4"/>
    <dbReference type="OMA" id="LAFHRVC"/>
    <dbReference type="OrthoDB" id="1917888at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033333">
        <property type="entry name" value="FANCB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28450">
        <property type="entry name" value="FANCONI ANEMIA GROUP B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28450:SF1">
        <property type="entry name" value="FANCONI ANEMIA GROUP B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="104784" checksum="DAB6BA472CD6B289" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHS8</accession>
    <name>A0A401PHS8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with GFM2. Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002161">
        <property type="protein sequence ID" value="GCB72686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHS8"/>
    <dbReference type="STRING" id="75743.A0A401PHS8"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000007">
        <property type="entry name" value="ribosome-recycling factor, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.20:FF:000003">
        <property type="entry name" value="ribosome-recycling factor, mitochondrial isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="9">
        <location>
            <begin position="99"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB72686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="262" mass="29151" checksum="2984CC338CB49B36" modified="2019-05-08" version="1">MSIVLRQMYQLGATLYKFRPLLMRSAVESRVGPAAVFLDNCKQCGALHVSLSRPLATKKTKVKSKGQPGPRVNINAALVEDIINLNELKQEMLEIIENLKNDYGKNLSIRTSPGALDHITVTTNNGKFPLNHLGQISLKSPQLILVNMMSFPEATMAATKAIRESGMNLNPEVDGTLIRVPIPKVTREHRENLAKLAKQFTNKSKESLRKMRTNAIAQVKKSKDSVSEDTIRLLEKQIQQMADDVVADMDKHLTAKTKELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI01</accession>
    <name>A0A401PI01_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytoplasmic dynein 1 intermediate chain 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cytoplasmic dynein intermediate chain 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Dynein intermediate chain 1, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0002168</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000525">
        <property type="protein sequence ID" value="GCB72756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI01"/>
    <dbReference type="STRING" id="75743.A0A401PI01"/>
    <dbReference type="OMA" id="KQEVKEX"/>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000108">
        <property type="entry name" value="cytoplasmic dynein 1 intermediate chain 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000026">
        <property type="entry name" value="cytoplasmic dynein 1 intermediate chain 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF34">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB72756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="580" mass="65356" checksum="2521261CA1365080" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI32</accession>
    <name>A0A401PI32_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitogen-activated protein kinase kinase kinase 4</fullName>
            <ecNumber evidence="4">2.7.11.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">MAPK/ERK kinase kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0006470</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01002187">
        <property type="protein sequence ID" value="GCB72790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PI32"/>
    <dbReference type="OMA" id="ETRICYR"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000122">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1296"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1199"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1205"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB72790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1561" mass="177517" checksum="3E4408B23BE7156F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJA3</accession>
    <name>A0A401PJA3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Selenide, water dikinase 1</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Selenium donor protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Selenophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0006669</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogenselenide + ATP + H2O = selenophosphate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the selenophosphate synthase 1 family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01002291">
        <property type="protein sequence ID" value="GCB73202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJA3"/>
    <dbReference type="STRING" id="75743.A0A401PJA3"/>
    <dbReference type="OMA" id="IRMDTCV"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000006">
        <property type="entry name" value="Selenide water dikinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000003">
        <property type="entry name" value="Selenide, water dikinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="SELENIDE, WATER DIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256:SF2">
        <property type="entry name" value="SELENIDE, WATER DIKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0711">Selenium</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="21">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="22">
        <location>
            <begin position="193"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB73202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="392" mass="42948" checksum="FD3AE8352D5B4D66" modified="2019-05-08" version="1">MSVRETFNPEHYELDKNFRLTRFAELKGTGCKVPQDVLLRLLEALQENHYQEDEQFLGAVMPRLGIGMDTCVIPLRHGGLSLVQTTDYFYPIVDDPYMMGRISCANVLSDLYAMGVTECDNMLMLLGVSNKMSSKERDKVMPLIIQGFKDAADEAGTSVTGGQTVLNPWIILGGVATTVCQPNEFIMPDNAVPGDVLVLTKPLGTQVAVAVHQWLDIPEKWNKIKLVVTQEDVELAYQEAMMNMARLNRTAAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETSGGLLICLPREQAARFCAEIKSPKYGEGYQAWIIGIVEKGNRSARIIDKPRIIEVAPTVATQNVNPTPGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJL8</accession>
    <name>A0A401PJL8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 128</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ferry endosomal RAB5 effector complex subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">KLRAQ motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0006721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002314">
        <property type="protein sequence ID" value="GCB73324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJL8"/>
    <dbReference type="STRING" id="75743.A0A401PJL8"/>
    <dbReference type="OMA" id="XFSQYLH"/>
    <dbReference type="OrthoDB" id="5566667at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040024">
        <property type="entry name" value="PPP1R21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049372">
        <property type="entry name" value="PPP1R21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019343">
        <property type="entry name" value="PPP1R21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019348">
        <property type="entry name" value="PPP1R21_six_helix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448">
        <property type="entry name" value="SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10205">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21636">
        <property type="entry name" value="PPP1R21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10212">
        <property type="entry name" value="PPP1R21_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01254">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 21 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="109"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="558"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB73324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="784" mass="89770" checksum="F4A3B9394BD82201" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJV3</accession>
    <name>A0A401PJV3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0002513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01000631">
        <property type="protein sequence ID" value="GCB73381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJV3"/>
    <dbReference type="STRING" id="75743.A0A401PJV3"/>
    <dbReference type="OMA" id="FYMFTRV"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000471">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="464"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB73381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="620" mass="70178" checksum="C40D4CAEDC11AF6D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKY7</accession>
    <name>A0A401PKY7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neurofascin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0002872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000742">
        <property type="protein sequence ID" value="GCB73790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKY7"/>
    <dbReference type="STRING" id="75743.A0A401PKY7"/>
    <dbReference type="OMA" id="XPTPDIA"/>
    <dbReference type="OrthoDB" id="10010359at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000367">
        <property type="entry name" value="Neural cell adhesion molecule L1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000038">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000078">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000114">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000238">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000347">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF35">
        <property type="entry name" value="NEUROFASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019162529" description="Neurofascin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="135"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="233"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="326"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="417"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="511"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="609"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="715"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB73790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="97316" checksum="25FD8544C0A191F9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLE0</accession>
    <name>A0A401PLE0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="14" type="ORF">scyTo_0003022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probably involved with other LSm subunits in the general process of degradation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000791">
        <property type="protein sequence ID" value="GCB73939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLE0"/>
    <dbReference type="STRING" id="75743.A0A401PLE0"/>
    <dbReference type="OMA" id="DQFANLM"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB73939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="122" mass="14012" checksum="2B92BF07020868DA" modified="2019-05-08" version="1">MGILKKHLVVLRDGRTLIGYLRSVDQFANLVLHRTVERIHVGRKYGDIPRGIFVVRGENVVLLGEIDLERETDTPLQKVSIEEILEAQRVQQHEKQEAEKAKSEALKERGLSIPRTDTLDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLS9</accession>
    <name>A0A401PLS9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Extracellular sulfatase</fullName>
            <ecNumber evidence="10">3.1.6.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0003125</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01000830">
        <property type="protein sequence ID" value="GCB74041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLS9"/>
    <dbReference type="STRING" id="75743.A0A401PLS9"/>
    <dbReference type="OMA" id="GFDYAKX"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002063">
        <property type="term" value="P:chondrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014846">
        <property type="term" value="P:esophagus smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035860">
        <property type="term" value="P:glial cell-derived neurotrophic factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032836">
        <property type="term" value="P:glomerular basement membrane development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030201">
        <property type="term" value="P:heparan sulfate proteoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060384">
        <property type="term" value="P:innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000003">
        <property type="entry name" value="Extracellular sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014615">
        <property type="entry name" value="Extracellular_sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024609">
        <property type="entry name" value="Extracellular_sulfatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF1">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12548">
        <property type="entry name" value="DUF3740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036665">
        <property type="entry name" value="Sulf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018825323" description="Extracellular sulfatase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="16">
        <location>
            <begin position="43"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Extracellular sulfatase C-terminal" evidence="17">
        <location>
            <begin position="532"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via 3-oxoalanine" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="11">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB74041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="866" mass="100411" checksum="8C7859E58C4C1F8B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PM15</accession>
    <name>A0A401PM15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 85 kDa-like CC4 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0003271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000881">
        <property type="protein sequence ID" value="GCB74184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PM15"/>
    <dbReference type="STRING" id="75743.A0A401PM15"/>
    <dbReference type="OMA" id="CHTWLPD"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000357">
        <property type="entry name" value="Cilia and flagella associated protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000271">
        <property type="entry name" value="cilia- and flagella-associated protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058190">
        <property type="entry name" value="CC4_CEP85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24555">
        <property type="entry name" value="CC4_CEP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 85 kDa-like CC4 coiled-coil" evidence="3">
        <location>
            <begin position="813"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="712"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB74184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1066" mass="123171" checksum="1E8950637CF5AF98" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PM81</accession>
    <name>A0A401PM81_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000889">
        <property type="protein sequence ID" value="GCB74218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PM81"/>
    <dbReference type="STRING" id="75743.A0A401PM81"/>
    <dbReference type="OMA" id="RCDSKSA"/>
    <dbReference type="OrthoDB" id="5978964at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="199" mass="22185" checksum="0DD683D491B588DA" modified="2019-05-08" version="1">MASSKNLERGQGQESASAQGSKKNEKFSLCLNVAGIDPRSVKVTITGRKLEISGQHVRKFKQGELGISRYNYCGFSNELRLPPNLDLNTLAATVTDDVIITIEAYHYSIGILVEVQDKDDDFFHPRMLPIVYKYTTASNPLTEDNKNKERSFWTPCLFPIPGTRCDSKSALVSVCHHPLPGSLCSYSPSNINFPKSERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN46</accession>
    <name>A0A401PN46_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0003626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001007">
        <property type="protein sequence ID" value="GCB74535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN46"/>
    <dbReference type="STRING" id="75743.A0A401PN46"/>
    <dbReference type="OMA" id="MNCINTA"/>
    <dbReference type="OrthoDB" id="10249393at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="111"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB74535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="306" mass="34582" checksum="54CC6FC55C099B02" modified="2019-05-08" version="1" fragment="single">KDVSDPGFNVDQKQIELQLELWRDKSLYAYQAQAVCMTRLLHEIKTLRTQVTSQKEQIKALTSDLEKAHKTNLQMEKIFLDYKLKKNFELLDMNCINTAGASPVQWDSAAEEFKQIEQQFMKSMEQESRLKNIQFVVTSVLKANLSEDTREMVEGCMNSMQEPMYRTIMYYCGGLNCAERLQHIIETGFSKEDFSDGIYGQGLYFSPNASTACMLSVPGLILVANVCIGNTETVMTKNRERDSASNGFDSILVPGRLCDEASFPNSRIAQEYVIFSPLQALPVGLLMYRSTASSDHSHEGSHHASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP26</accession>
    <name>A0A401PP26_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0019667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014858">
        <property type="protein sequence ID" value="GCB74858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP26"/>
    <dbReference type="OMA" id="GFNECIR"/>
    <dbReference type="OrthoDB" id="8407241at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000001">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF107">
        <property type="entry name" value="CRYGMX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB74858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="175" mass="21485" checksum="04E50F3CBB7B4FB0" modified="2019-05-08" version="1">MGKIIFYEDRNFQGRHYECSSDCADLSPFFSRCNSIRVESDWWVVYEKPNYMGYQYVLSRGEYPDYQRWMGFNECIRSCRSYPHSRGGSYKMRIYERPDFGGQMMEFMDDCPSVYDRFRYRDIHSCQVMDGYWIFYEHPNYRGQQYFLRPGEYRRYSDWGGFNSTIGSFRRMRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPB3</accession>
    <name>A0A401PPB3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-binding protein 5</fullName>
            <shortName evidence="4">SH3BP-5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0018925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Functions as guanine nucleotide exchange factor (GEF) for RAB11A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with GDP-bound and nucleotide-free forms of RAB11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Colocalizes with RAB11A on cytoplasmic vesicle membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SH3BP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013622">
        <property type="protein sequence ID" value="GCB74945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPB3"/>
    <dbReference type="STRING" id="75743.A0A401PPB3"/>
    <dbReference type="OMA" id="ANEEGKY"/>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF8">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="61"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB74945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="272" mass="30931" checksum="EB87595A7D0E2911" modified="2019-05-08" version="1">MGITSHRLLLVLKAQQETQKAALRYERAVSMHNAAREMVYVAEQGLMADRNRLDPTWQEMLNHATSKVNEAEEERLRSEREHQRVTQMCQEAEGRVQELQKSLKRVIIKSKPYFELKAQFNQILEEHKAKVTALEKQVSQAKTKYSVALRNLEQISEQIHARRLQRLGCRRASPVGAEARPAYLEEERGEAAMVVDKASAHTPLGAEGPPSDTISVLSFQTIASDLQKFDSVEHLEELSDALSLDSDDLTRDTDRLKGPSSFFFKHHRSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPI7</accession>
    <name>A0A401PPI7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0018942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013648">
        <property type="protein sequence ID" value="GCB75018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPI7"/>
    <dbReference type="STRING" id="75743.A0A401PPI7"/>
    <dbReference type="OrthoDB" id="6083617at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF46">
        <property type="entry name" value="DISPANIN SUBFAMILY A MEMBER 2B-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB75018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="172" mass="18383" checksum="400827249E441537" modified="2019-05-08" version="1">MRHPGNRGSRQIVVGETPTMEGVKSPHQGMIEVENSCGQAGTTIPLSVRWDQAGSLPPGDEESGGRSPSPTGRSDYVTIQIQSLTTPSPAPPKVPDYLGCSLFATMFCFLPLGVAALVYSVKTWSANRAGTTAAARRNLMISRQLNIGAVLIGLIVHFVWVARLIITVIERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQP6</accession>
    <name>A0A401PQP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">succinate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0020362</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01016353">
        <property type="protein sequence ID" value="GCB75448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQP6"/>
    <dbReference type="STRING" id="75743.A0A401PQP6"/>
    <dbReference type="OMA" id="TLIDETW"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB75448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="147" mass="16730" checksum="64E33C16D29B2A5C" modified="2019-05-08" version="1" fragment="single">CMQSHAAVFRTGSVLKEGCEKLGELYGSLDDIKTFDRGIVWNSDLIETLELQNLMLCALQTIYGAEARKESRGAHAREDFKMRIDEFDFSKPLQGQEKKSFNEHWRKHTISRVDPKTGKVTLEYRSVIDTTLDAKDCASVPPAIRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR96</accession>
    <name>A0A401PR96_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0015354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008674">
        <property type="protein sequence ID" value="GCB75631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR96"/>
    <dbReference type="STRING" id="75743.A0A401PR96"/>
    <dbReference type="OMA" id="MFSETRI"/>
    <dbReference type="OrthoDB" id="6353782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF59">
        <property type="entry name" value="HEPATIC AND GLIAL CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="6">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB75631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="307" mass="34471" checksum="B6D262EA53755B79" modified="2019-05-08" version="1">MGNPIELPVAVGSSVLLPGFTDQHFQNVDHVKWTFSQTRILNYDEATQTATFINSYKNRCTFYRSNGSLLLRNITRNDEGRYEVQINLNEIRSRMIQLKVFGLPPLIHHTMVLSIVALISATAIFFGIILQCLHNEMQKMDFQRKALLFLQVAAMLSFIILFAALLCWLQAGGTSAVTVFMLVILSLLLILTTLSACSMNGWVIETFKQILNTKCCRVTLDAVTPMGGLIVICTSSILLWEINKLAGKGCEPSPDLHLRISLAVVVPIVISVLIFGIYVRQCRISREERAWRDDMQCQDNISLKDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRA9</accession>
    <name>A0A401PRA9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009945">
        <property type="protein sequence ID" value="GCB75650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRA9"/>
    <dbReference type="STRING" id="75743.A0A401PRA9"/>
    <dbReference type="OMA" id="ERRYKPG"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="60"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB75650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="613" mass="68995" checksum="57826B4A472EBCD8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRG1</accession>
    <name>A0A401PRG1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hedgehog N-terminal signalling domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015117">
        <property type="protein sequence ID" value="GCB75703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRG1"/>
    <dbReference type="STRING" id="75743.A0A401PRG1"/>
    <dbReference type="OMA" id="CVVNVEF"/>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050387">
        <property type="entry name" value="Hedgehog_Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000320">
        <property type="entry name" value="Hedgehog_signalling_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Zn_M74/Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889">
        <property type="entry name" value="HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889:SF31">
        <property type="entry name" value="PROTEIN HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01085">
        <property type="entry name" value="HH_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="Hedgehog/DD-peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hedgehog N-terminal signalling" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="12901" checksum="F92833B2FEC46901" modified="2019-05-08" version="1">MGCGPGRGYGSRRRQNRKLTPLSYKQFIPNVAEKTLGASGKSDSKINRNASRFKELIPNYNPDIIFKDEEKSGADRLMTQFGCVVNVEFGCVVNVQFGCVVIVEFCCVVNVEFGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRV8</accession>
    <name>A0A401PRV8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015148">
        <property type="protein sequence ID" value="GCB75858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRV8"/>
    <dbReference type="STRING" id="75743.A0A401PRV8"/>
    <dbReference type="OMA" id="VQDDHSC"/>
    <dbReference type="OrthoDB" id="10066782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="386" mass="42904" checksum="3045E87C87E40E1F" modified="2019-05-08" version="1" fragment="single">CRIDIHSILSTCSLVQDDRSCTLVQDDRSCSLVQNDRSCSLVQDDHSCSLVQDDRSCSLLEDDPSCSLVQDDHCCSLVQDDHSCSLVQDDHPCSLVHDDCSCSLVQDDRSCSLVQDDRSCSLVQDDRSCSLVQDDRSCSLVQNDRTCSLVQDDHSCSLVQDDRSCSLLQNDPSCSLVQEYRPCSLVQDDRSCSLVQDDRCCSLVQDDRSCSLIQNGRSCCLVQDGRSCCLVQDGRSCCLVQDDRSCSLVQDDRSCSLVQDDRSCSLVQDDRSCSLVQDDHSCSLGKDDHSCPLVQDDHSCSLIQDGRSCSRMAAPAPCCTLTLVAISSRSIRGWRLLRTFTQHSWSGDSSRSTIQGTGTRAQSHTVWSMRRVRDDAEQRLLEREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSC2</accession>
    <name>A0A401PSC2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01008731">
        <property type="protein sequence ID" value="GCB75993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSC2"/>
    <dbReference type="STRING" id="75743.A0A401PSC2"/>
    <dbReference type="OMA" id="YRYCVDG"/>
    <dbReference type="OrthoDB" id="8957712at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001738">
        <property type="entry name" value="TRAF2 and NCK interacting kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="8">
        <location>
            <begin position="963"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="726"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB75993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1276" mass="144875" checksum="55281BB2A41BF9D8" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSM3</accession>
    <name>A0A401PSM3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0020980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01017791">
        <property type="protein sequence ID" value="GCB76115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSM3"/>
    <dbReference type="STRING" id="75743.A0A401PSM3"/>
    <dbReference type="OMA" id="RCFTITF"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000088">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF209">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB76115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="15193" checksum="750CB527C692B683" modified="2019-05-08" version="1" fragment="single">LHDDEDVKFMLKGSKLKKVKSGTWKKNRWMKLQEDGLSIWCESRNKAPPTFSVMDIRAIQEGHQSEVMKKHCNSFSAKQCFTIVFMGSRTTLDLVATSEEEGRRWVQGLKKLIQRVETMSQREKIEQYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV05</accession>
    <name>A0A401PV05_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0016632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010174">
        <property type="protein sequence ID" value="GCB76970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV05"/>
    <dbReference type="STRING" id="75743.A0A401PV05"/>
    <dbReference type="OMA" id="SHWHERC"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000072">
        <property type="entry name" value="Four and a half LIM domains protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042997">
        <property type="entry name" value="Fhl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47029">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47029:SF2">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB76970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="181" mass="20569" checksum="0BF4FE99F9CE5E5C" modified="2019-05-08" version="1">MVNCQLVNQLPAGTKSFEHGGSHWHERCFTCSRCLKEIGTGSFIPKGDDIYCTSCNEKKFSKHCVHCRKAITSGGLTYRDEPWHTECFVCKTCRKQLGGQRFTAHENYIYCTDCYGNFIAKKCGACHKPVTGFGGAEVVTYEDRQWHSECFKCKKCYGSLVNKRFVTHNRDVYCPDCGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV54</accession>
    <name>A0A401PV54_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0019227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014086">
        <property type="protein sequence ID" value="GCB77020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV54"/>
    <dbReference type="STRING" id="75743.A0A401PV54"/>
    <dbReference type="OMA" id="LLRYWEC"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF2">
        <property type="entry name" value="PROTEIN YIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB77020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="18945" checksum="68CB1D4F0C3339FD" modified="2019-05-08" version="1" fragment="single">GILSLLRPGNLSVPQAPKQRVRPPAPSTMDPNQLFDDTSAAAQPPQPGSYTVQGIDMGLPINSFLGEPVADFAMAYGTTIASQGKDIVHKELNRFVSVNKLKYFFTVDTRYVSKKLALLMFPYTHQNWELGYRVDSRLTPREDFHANAPDLYIPNFLLRYWECVRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWA4</accession>
    <name>A0A401PWA4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0017595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011569">
        <property type="protein sequence ID" value="GCB77388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWA4"/>
    <dbReference type="STRING" id="75743.A0A401PWA4"/>
    <dbReference type="OMA" id="MCENSVR"/>
    <dbReference type="OrthoDB" id="9946218at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="85"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB77388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="184" mass="20935" checksum="8C4B2C1A18323CFE" modified="2019-05-08" version="1">MDSSEVEPGTSTADSAAESSLVVEESFFSTLDIFLFSLIAGFAIYWFVFRKKKVEIPDYKTLQPQVQTIRETSFIEKMKKTGKNIVVFYGSQTGTAEEFANRLSKDAQRYGMRGMATDPEEYDMSELNRLTEIENTLAIFCMATYGEGDPTDNAQDFYDWMQETDLDLTGVKYAVSIKENKQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX52</accession>
    <name>A0A401PX52_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0015690</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>H2O2(out) = H2O2(in)</text>
            <dbReference type="Rhea" id="RHEA:74375"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009014">
        <property type="protein sequence ID" value="GCB77623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX52"/>
    <dbReference type="STRING" id="75743.A0A401PX52"/>
    <dbReference type="OMA" id="FWIPVAS"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023275">
        <property type="entry name" value="Aquaporin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF7">
        <property type="entry name" value="AQUAPORIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02015">
        <property type="entry name" value="AQUAPORIN3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019208082" description="Aquaporin" evidence="15">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB77623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13905" checksum="D708E7A53FA726A4" modified="2019-05-08" version="1" fragment="single">AIGTAALILCILIIVDPLNNLVPTGLEAFTIGCVVLMIGWSMGLNSQYSLNPARDIGPRLFTAIAGWGSEVFSAGNYWFWIPVASPIIGAILGVLIYRFIVGLRAEAKTSCSPNAEQNVKLLSQKPKGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXS9</accession>
    <name>A0A401PXS9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VASP tetramerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0020043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015625">
        <property type="protein sequence ID" value="GCB77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXS9"/>
    <dbReference type="STRING" id="75743.A0A401PXS9"/>
    <dbReference type="OrthoDB" id="31170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000003">
        <property type="entry name" value="protein enabled homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VASP tetramerisation" evidence="6">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB77908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="57" mass="6476" checksum="B3E3A9D1FE56EDAA" modified="2019-05-08" version="1" fragment="single">SKSTSSGPANTNGVQTEILDYDRLKQDILEEMRKELQKLKEELINAIRQELSKSNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXZ7</accession>
    <name>A0A401PXZ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7802 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012999">
        <property type="protein sequence ID" value="GCB77913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXZ7"/>
    <dbReference type="OrthoDB" id="188749at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056704">
        <property type="entry name" value="DUF7802"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982">
        <property type="entry name" value="AGAP005361-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982:SF1">
        <property type="entry name" value="SPIROCYCLASE, AVEC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25085">
        <property type="entry name" value="DUF7802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7802" evidence="2">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10538" checksum="6FE4A9B87B7BBCA4" modified="2019-05-08" version="1">MVDWSWWVTLRDPRDIWVKHPTLILNELAFYVVALLSLKHAVRNGGRWKYLWVATIIHGVTTEAVSYLLPDVDSFWHAQSSVMFLGKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY42</accession>
    <name>A0A401PY42_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 15">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0016775</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 15"/>
    <dbReference type="EMBL" id="BFAA01010371">
        <property type="protein sequence ID" value="GCB78020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY42"/>
    <dbReference type="STRING" id="75743.A0A401PY42"/>
    <dbReference type="OMA" id="YWTAAQQ"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="17">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="16">
        <location>
            <begin position="131"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB78020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="402" mass="44517" checksum="475BB24D24EE5D8B" modified="2019-05-08" version="1" fragment="single">RFSAANMSFVKVAEHSDFPLQNLPFGVFSTGDNPTHRIGVAIGDQILDLSIVKHLFTGSALSKHQDVFAQPTLNSFMALGRKAWKEARAFLQQFLSADESTLRDNKELRKKAFVAQSSASMHLPAHIGDYTDFYSSRQHATNVGIMFRGKENALMPNWLHLPVAYNGRASSVIVSGTPVRRPMGQTRPDETKPPVFGACKLLDIELEMAFFIGPGTKLGETIDISQAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTISPWVVSMEALQPFIVANPTQDPKPLPYLCSDDPYTFDINLFVSIKGEAMPEKATVCRSNFKHMYWTLRQQLAHHTVNGCNVRPGDLLASGTISGPAVESFGSMLELSWKGTKAIDLGNGQTRKFLQDGDEVTLTGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZW7</accession>
    <name>A0A401PZW7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PI3K/PI4K catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0018640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013162">
        <property type="protein sequence ID" value="GCB78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZW7"/>
    <dbReference type="STRING" id="75743.A0A401PZW7"/>
    <dbReference type="OMA" id="HETDIAY"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000005">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="90"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB78658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="373" mass="42926" checksum="535261777C0049F1" modified="2019-05-08" version="1">MKTNIYTDEEGNHKDPDIGELLEQLIEEITGSLSGPAKDFYQREYDFFDKITNVSAIIKYLLLMQYSQFKQVIKHFPKKIVNGLCVCCKIPKCLRSCSGCTDDSTERDDSETICWQAAIFKVGDDCRQDMLALQIIGLFKNIIQLVGLDLFVFPYRVVATSPGCGVIECIPDCKSRDQLGRQTDFGMYDYFRNQYGDESTLAFQKARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDRKGHLIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVKGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKQRFNPNVSEREAANFIMKVIQNCFLSNRSKTYDMIQYYQNQIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0B0</accession>
    <name>A0A401Q0B0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011857">
        <property type="protein sequence ID" value="GCB78815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0B0"/>
    <dbReference type="STRING" id="75743.A0A401Q0B0"/>
    <dbReference type="OrthoDB" id="9990458at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF5">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB78815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="14220" checksum="FD2D339690D5271B" modified="2019-05-08" version="1">MCKLHTDSTFKGICKIIDHFPEDADYEQDTAEYLLRIVRASSVFPILSVGLLFLGGVCVAAGEFYKSKHNVVLSSGIFFVAAGLSFFNGFMWINQISWISANAFVLFNFDSKLYNHLFTTDYSNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q179</accession>
    <name>A0A401Q179_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transferrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0016911</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the transferrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010583">
        <property type="protein sequence ID" value="GCB79100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q179"/>
    <dbReference type="STRING" id="75743.A0A401Q179"/>
    <dbReference type="OMA" id="EAQPRTH"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000095">
        <property type="entry name" value="Lactotransferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016357">
        <property type="entry name" value="Transferrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018195">
        <property type="entry name" value="Transferrin_Fe_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF31">
        <property type="entry name" value="SEROTRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002549">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00206">
        <property type="entry name" value="TRANSFERRIN_LIKE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00207">
        <property type="entry name" value="TRANSFERRIN_LIKE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0410">Iron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019203368" description="Transferrin-like domain-containing protein" evidence="14">
        <location>
            <begin position="19"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="15">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="15">
        <location>
            <begin position="356"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="369"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="411"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="463"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="489"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB79100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="704" mass="76869" checksum="290E05EB5CB61F6D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1R7</accession>
    <name>A0A401Q1R7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009337">
        <property type="protein sequence ID" value="GCB79294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1R7"/>
    <dbReference type="STRING" id="75743.A0A401Q1R7"/>
    <dbReference type="OMA" id="CKEQPEY"/>
    <dbReference type="OrthoDB" id="9949340at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052642">
        <property type="entry name" value="CC-FHA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18853:SF9">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18853">
        <property type="entry name" value="FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="377" mass="43440" checksum="E4CE84F30838010B" modified="2019-05-08" version="1" fragment="single">MEDSDDCIDCKEQPEYSAASDGVPWYVAVLHEKEKCVLILEDKVKILSQFEAESKRKDGIIANLQKEVAELIEELNKSSDSNSLKTQAQATVTMQEKVNKLKEMESDNKRKDGIIAKLRDEVWQQGLQISHLRFESSISITDTMLDESFSVMPRDYVWESKSELSEIIEHPSGELNTQENFDQVGIQFVVNPADEDASDHDEEEYEMVDHGAETRESEFFDSEEASDHELEGKPEELTKLIYQNESLKKKLKEMRQHYNMSRGAIISINRSKSLAEAQLQTTEANMERLQKELKERCYQLHDMSNKLVAELQSELTMKTEETVKMKTEIDLLRLHDAAEDVRKKQLESDYDSVTAEGKLMQRELQDLQIALKFTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q244</accession>
    <name>A0A401Q244_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Growth hormone-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017331">
        <property type="protein sequence ID" value="GCB79499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q244"/>
    <dbReference type="STRING" id="75743.A0A401Q244"/>
    <dbReference type="OrthoDB" id="9890215at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025871">
        <property type="entry name" value="GHBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12772">
        <property type="entry name" value="GHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Growth hormone-binding protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="322" mass="34598" checksum="D4AB41083E3601C1" modified="2019-05-08" version="1" fragment="single">KGKIDEVNSIFANHLSYKSDLYIDDPWVEFIDIDLDDPDGKAEMADTDRLLGQGHLKSNKCLSVKDDDSGRDSCYEPDVSDEVTTGKHSEFSSLQLEASKRKEDVKSDNGVPFDISGADATWSQQPNSEGCDCSKSQLVTTDKGLSTVTKHGLSQPAPHSPLGNQGSFGKMDFYAQVSDITPTGGVLLSPGQQNKLQVSQAKDTSPDTKAGQKTKPPDKAYTSEADAMQLCALSSGKLGRHDAGEDLNLSSYFTTEGLASVTVGSCKQTGNSRHPTIPAPDYTSIHMVDSQQSLLLNPNEPSNNQPIQAGYLMPEQLGNVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2L4</accession>
    <name>A0A401Q2L4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014705">
        <property type="protein sequence ID" value="GCB79632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2L4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="398" mass="41851" checksum="709E73230EAFF6E6" modified="2019-05-08" version="1">MWCHSVHGGPEGAASRCATLASRCATLASRCATLASHSATPGISLCHARHLAVPRWHLTLPRPASHCATLASRCATPGISLCHARHLAVPRPASHSATPGISLCHTGISLPRPASSCATPGISLCHTGISLCHARHLAVPRPASRCATPGISLCHAGISLCHAGISLCHAGISLCHAQHLAVPHWHLAVPRPASRCATLASHSATPGISLCHAGISLCHARHLAVPRWHLTLPRPASRCATLASHCATPGISPCHARHLALPRPASRCATLASHCATPGISLYHARHLAVPRWHLAVPRWHLAVPRPASRSATPDISPCHAGISLCHARHLALPRPASRCATPGISLCHARYLAVPRWHLAVPRPASRCATPGISLCHARYPGEGASRMEKNPGKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2U4</accession>
    <name>A0A401Q2U4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014708">
        <property type="protein sequence ID" value="GCB79643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2U4"/>
    <dbReference type="STRING" id="75743.A0A401Q2U4"/>
    <dbReference type="OMA" id="IFINYEA"/>
    <dbReference type="OrthoDB" id="9927450at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF8">
        <property type="entry name" value="FSD1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="17105" checksum="446D01D3FDB0C46C" modified="2019-05-08" version="1" fragment="single">TGDAVIESGQHYWEVKSQKDCKSYSIGVSYRNLGKFDQLGKTVTSWCVHINNWLQTSFAAKHNNKAKFMDTQVPDKIGVYCDYDGGHISFYNADTKQLLHTFKTKFAQPVIPAFMVWCGGLNLYTGLQVPSAIKSFQKGDGGLGGSENSLIGLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2X4</accession>
    <name>A0A401Q2X4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0016023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009421">
        <property type="protein sequence ID" value="GCB79704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2X4"/>
    <dbReference type="STRING" id="75743.A0A401Q2X4"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB79704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="10934" checksum="9896A2C6BDA327E9" modified="2019-05-08" version="1">MMSSPCGDDREVAALLTEDTKMSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPGTCKADIDGVCLSRCVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3L0</accession>
    <name>A0A401Q3L0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0018849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013509">
        <property type="protein sequence ID" value="GCB79966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3L0"/>
    <dbReference type="STRING" id="75743.A0A401Q3L0"/>
    <dbReference type="OMA" id="FIEMADD"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB79966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="175" mass="17819" checksum="5CDD74E95726281E" modified="2019-05-08" version="1">MTDRNDDRKLFVGGLSFDTDEQALEAVFSKYGDVVDARVIKDKCTLASRGFGFVTFENSENASDAMKALNGQSLDGRQIRVDHAEKKSGDGGYGGGRGGGGGYRRGGSSYGGYGSSGGYGGGGGYSTGYGGGGGGYGGGGGYGGGGGYGSSNYKQYEYKGSGNSRGGSYERYSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3M1</accession>
    <name>A0A401Q3M1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CATSPERD/E C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0017044</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell projection</location>
            <location evidence="12">Cilium</location>
            <location evidence="12">Flagellum membrane</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CATSPERD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010769">
        <property type="protein sequence ID" value="GCB79940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3M1"/>
    <dbReference type="STRING" id="75743.A0A401Q3M1"/>
    <dbReference type="OrthoDB" id="5968869at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097228">
        <property type="term" value="C:sperm principal piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028751">
        <property type="entry name" value="CATSPERD/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053814">
        <property type="entry name" value="CATSPERD/E_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33722:SF3">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33722">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22850">
        <property type="entry name" value="CATSPERD-E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CATSPERD/E C-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB79940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="15443" checksum="E5E87A1A54F31953" modified="2019-05-08" version="1" fragment="single">PYLSGCETNNITFYKIPRSALREPVENDVTVAYNRKIFGCPIRVYYKTPFKPVLKLYMGEKFINIVYANYIIWEVQGRTDFYYNTTMREAGCQQEAQTWKSMLYYHKGSYLNREDIWGPWVNVIFLMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q428</accession>
    <name>A0A401Q428_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0017079</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010804">
        <property type="protein sequence ID" value="GCB80091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q428"/>
    <dbReference type="STRING" id="75743.A0A401Q428"/>
    <dbReference type="OMA" id="ECESTMR"/>
    <dbReference type="OrthoDB" id="5981530at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000019">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF74">
        <property type="entry name" value="LP13728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="168"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB80091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="485" mass="54422" checksum="69427714EFD24333" modified="2019-05-08" version="1" fragment="single">NAFQGMNNESLTLKLYKNGFEDVQSHAFNATKLDKLELNENKNLRTIHNDAFRGAIGPDVFFGNDYSHPGLPPLQLGERSLQNHSSVAKKHPSSQNGSHFHENMPDAEYEHLEEIYENSVSFDYGFCHSKVDLVCTPEPDAFNPCEDIMGYNILRVLIWFINILAIVGNFVVFTVLVISQNKLTVPRFLMCNLAFADLCMGLYLLLIASVDLSTRSQYYSYAIDWQTGAGCASAGFFTVFASELSVYTLMVITFERWHTITHAMQMDRKLRLRHAIVIMSGGWIFSLVVATLPLVGISNYMKVSICLPMDIETPMSQAYVIFLLVLNVMAFIIICVCYIKIYLAVKNPDFVSKNSDAKIAKRMAILIFTDFMCMAPISFFAISAAFKSPFITVTNAKILLVLFYPLNSCANPFLYAIFTKAFRRDFFILLSRFGYCEMQAHIYKTDNSSSKSGTKENSGAAVKLTTFSVQDLPPGASAEFCCGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5B2</accession>
    <name>A0A401Q5B2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apolipoprotein A-IV</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Apolipoprotein A4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0016259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein A1/A4/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009715">
        <property type="protein sequence ID" value="GCB80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5B2"/>
    <dbReference type="STRING" id="75743.A0A401Q5B2"/>
    <dbReference type="OMA" id="QAKMSPY"/>
    <dbReference type="OrthoDB" id="9048614at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042627">
        <property type="term" value="C:chylomicron"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034362">
        <property type="term" value="C:low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034361">
        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060228">
        <property type="term" value="F:phosphatidylcholine-sterol O-acyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055090">
        <property type="term" value="P:acylglycerol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033700">
        <property type="term" value="P:phospholipid efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000074">
        <property type="entry name" value="ApoA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF1">
        <property type="entry name" value="APOLIPOPROTEIN A-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01442">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0162">Chylomicron</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB80573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="406" mass="46761" checksum="55EC13F6A122C9F2" modified="2019-05-08" version="1">MVIDVLETALVRERACGIGTLNLRRGRGEAEKQKSCLMCTLFKKSAMFPRAILVLLAANLLSGSQAEVNEGQVQDAFWDYISQLTNDAKDSIDQIQGSEISQQLHHSLKDNLETVNGYAENLRQKLAPLTDELHLKMKVDTENLQQRIREELHILRTKLSPFADGVQQRLSRNLKEFHQKLTPYTEELGQQLRNNAEELRQTVIPYTKVLQDKLKENAENLRDVLAPYTEVLQQEINENVDNLRQKVTINAEEFRSKFDEKVEELRNSLAPFANDVQVKMNQQIGEMTQRVVPYAEELQAKVNENLEVLKQGLVPYVTELKANFNKNIGSMTQNLAPYIDDLNSNINQRVAEFQQNMAPYSEQLNQIISQNMEEMQAKLGQYTDVHQDLHLQLTDLWDKFHQNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7C6</accession>
    <name>A0A401Q7C6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Dynein light chain Tctex-type 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0022483</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022701">
        <property type="protein sequence ID" value="GCB81268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7C6"/>
    <dbReference type="STRING" id="75743.A0A401Q7C6"/>
    <dbReference type="OMA" id="NIVTCAV"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21463">
        <property type="entry name" value="DLC-like_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF20">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="18" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0243">Dynein</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-0944">Nitration</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00072460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB81268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="11689" checksum="AE3A245B785C163D" modified="2019-05-08" version="1" fragment="single">VVFSADEASNIIKECVDSIIGGIDYNHSKINQWTAAVVEQSLMHLVKMGKPFKYIVTCAIMQKSGAGLHTASSCYWDSSTDGSCTVRWENRTMYCVISVFAVSIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8A8</accession>
    <name>A0A401Q8A8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020294">
        <property type="protein sequence ID" value="GCB81604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8A8"/>
    <dbReference type="OrthoDB" id="8718740at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="87" mass="9690" checksum="8E2BE1669A488A7B" modified="2019-05-08" version="1" fragment="single">VVHLDSTKEEEEEEEEPKIPMQTQYYDMAAPESSPYSEKSTTGAKDYDIQYAELDTTALASSHPSPRTSIHAGGDLVEYATIQPNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8H6</accession>
    <name>A0A401Q8H6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Death effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0022215</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021651">
        <property type="protein sequence ID" value="GCB81661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8H6"/>
    <dbReference type="STRING" id="75743.A0A401Q8H6"/>
    <dbReference type="OMA" id="FQIVGAQ"/>
    <dbReference type="OrthoDB" id="6422954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008625">
        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08790">
        <property type="entry name" value="DED_DEDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000004">
        <property type="entry name" value="Death effector domain-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038856">
        <property type="entry name" value="DEDD/DEDD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15205">
        <property type="entry name" value="DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15205:SF2">
        <property type="entry name" value="DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DED" evidence="14">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB81661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="142" mass="16378" checksum="65D089F45E109A50" modified="2019-05-08" version="1" fragment="single">MADAKGSGQQWPEEQVNSEHGLYSLHRMFQIVGAQLTHRDVRVLSFLFVDVIEDYERGMIRSGRDFFLALERQGRCDETNFRQVLQLLRIITRHDLLPYVTLKRRKTVSPDPVDKYLEDTSVTYVMPRTLAATRGGDYGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9P1</accession>
    <name>A0A401Q9P1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020590">
        <property type="protein sequence ID" value="GCB82099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9P1"/>
    <dbReference type="STRING" id="75743.A0A401Q9P1"/>
    <dbReference type="OMA" id="LQRGHCF"/>
    <dbReference type="OrthoDB" id="9990458at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="79" mass="8631" checksum="3E632AAC18DCFF9E" modified="2019-05-08" version="1" fragment="single">MTALGLQRGHCFRINYFPEDDDYDQEGSEYLLRIVRASSLFPILSAILLLLAGLCVGAGKLYSSKHNIILSAGILFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QA88</accession>
    <name>A0A401QA88_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial translation release factor in rescue</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0021578</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts (via C-terminus) with MTRES1 (via S4 domain). Associates with mitoribosomal S39 large subunit, peptidyl tRNA and nascent chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019387">
        <property type="protein sequence ID" value="GCB82299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QA88"/>
    <dbReference type="STRING" id="75743.A0A401QA88"/>
    <dbReference type="OMA" id="MSIKSWR"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000054">
        <property type="entry name" value="Chromosome 12 open reading frame 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019358812" description="Mitochondrial translation release factor in rescue" evidence="12">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="13">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB82299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="172" mass="19662" checksum="B67DB5A5CAE97651" modified="2019-05-08" version="1">MTSSILYNFVLSLARAQALSVRQWNLSSSAKTFLEVEHTCLLMPIAGKKGFPDLPVVVEDELDEQFVRGRGPGGQATNKTSNCVVLKHIPSGIVVKCHQTRSVDQNRKIARTILQEKLDVHYKGENSEIMKQKQEQQWKKQEKKRKAKDNLERKRQFKDILEVSSDVTEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB86</accession>
    <name>A0A401QB86_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020978">
        <property type="protein sequence ID" value="GCB82641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB86"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="8493" checksum="9FAE1E614F2E1864" modified="2019-05-08" version="1">MQKLEIEFEKEALAKEASERKTELQREKRIRQDALMKKYLGHMDKKEKLRDQTMARVQLRVLMEQSIFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBK1</accession>
    <name>A0A401QBK1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01036176">
        <property type="protein sequence ID" value="GCB82764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QBK1"/>
    <dbReference type="OMA" id="WGWELGR"/>
    <dbReference type="OrthoDB" id="9947453at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF15">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="33"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="233" mass="25057" checksum="FAAA2DA870B68B93" modified="2019-05-08" version="1">MGLKLVKSLKEEKEAGQSQGLQQFRGLGVPVPANLELLLDLPPVPREEQIHHTWSSWDRSPNMRPTGDVAESDELTARRRAVPDSTDCARGRVGYRQGLHVWRVGWPPGQRGSHAAVGVGTAAARLQAPGYRVLLGGAGDGQSWGWELGDNRLHHAGKAGRRYPEAPGGALPVPEDFLAVLDSDAGTLGFIVDGEYLGVAFDGLKGKALYPMVSCVWGNTSVTLTYVNTLESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBR0</accession>
    <name>A0A401QBR0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01031202">
        <property type="protein sequence ID" value="GCB82835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBR0"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="61" mass="7538" checksum="9D3065F51D812771" modified="2019-05-08" version="1" fragment="single">CCEDCQQWVPGVMFGARKRRFKFYCAECRARRRELGRKLNYYKVRMRCVVPQLLWSYWQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCR9</accession>
    <name>A0A401QCR9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034448">
        <property type="protein sequence ID" value="GCB83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCR9"/>
    <dbReference type="STRING" id="75743.A0A401QCR9"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13641" checksum="294B78F2F406FCDD" modified="2019-05-08" version="1" fragment="single">ERPRISTSTLDLASLRELPEGTFGKEYVRFLDVNRVTPDSRMPVKFVDDEELAYVIQRYREVHDFMHTLLGMPTNILAIINDETTKLCQFSISWIEMAAKTDGLKVPFAGCKGMNNEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCY4</accession>
    <name>A0A401QCY4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Chondrichthyes</taxon>
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            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01035760">
        <property type="protein sequence ID" value="GCB83202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCY4"/>
    <dbReference type="STRING" id="75743.A0A401QCY4"/>
    <dbReference type="OMA" id="QYKFDMV"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="14375" checksum="C358837752481BE7" modified="2019-05-08" version="1" fragment="single">INSSVMQGRAGAIQAAITIEMSSDVVTSFDISVEGLNGQLPNLDLVNLFTSFCQKNGVLCTIQGKLPRMDGETLEGYKHSLNTMMLMVLKQGSGKSQGDHGLFLRYHIEAVTIRAINSFRQYKFDMVTVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD83</accession>
    <name>A0A401QD83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bcl-2 Bcl-2 homology region 1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029559">
        <property type="protein sequence ID" value="GCB83358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD83"/>
    <dbReference type="STRING" id="75743.A0A401QD83"/>
    <dbReference type="OMA" id="QHIGDEL"/>
    <dbReference type="OrthoDB" id="6080198at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF42">
        <property type="entry name" value="APOPTOSIS REGULATOR BAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="3">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="14422" checksum="587F4CD096781C00" modified="2019-05-08" version="1">MRTGVTLLRGFIVERTNRRAEGCENPLTITELGGKENELCNPDVKRLGVCLRQIGDELDGNMELQRMIENIGSKCPKEMFFKVAKEQFADGVINWGRVVTLFYFACKLVVKVQLLSVGEGRRGVDAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE96</accession>
    <name>A0A401QE96_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0024318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01043191">
        <property type="protein sequence ID" value="GCB83738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE96"/>
    <dbReference type="STRING" id="75743.A0A401QE96"/>
    <dbReference type="OrthoDB" id="6355676at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023257">
        <property type="entry name" value="Liver_X_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF509">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02034">
        <property type="entry name" value="LIVERXRECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB83738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="158" mass="18217" checksum="608B35D397FC1351" modified="2019-05-08" version="1" fragment="single">EQQPAKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKSAQYSCKNSGQCQMDMYMRRKCQECRLRKCRQAGMLEQSRGGTERHQSVYRYLPERERGLRDTSQCTDISLRERGLRGTSQCTDISLREKLRDTSQCTDISLRERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEW8</accession>
    <name>A0A401QEW8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01048829">
        <property type="protein sequence ID" value="GCB83968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEW8"/>
    <dbReference type="OrthoDB" id="6132998at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8375" checksum="6284BADE6A3F3AC9" modified="2019-05-08" version="1" fragment="single">ARLPPSLTQSQREGRFCETLQRTEPFPQEYWYNTRLGTMSKSIESIMNDVDSSRCVGIEISNKSRSYILTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGC0</accession>
    <name>A0A401QGC0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01072802">
        <property type="protein sequence ID" value="GCB84468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGC0"/>
    <dbReference type="STRING" id="75743.A0A401QGC0"/>
    <dbReference type="OrthoDB" id="442428at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="90" mass="10463" checksum="84EAFF6C29D5DD52" modified="2019-05-08" version="1">MCDFAGRISTSQWALAVESVLHLHLPWRTLRSRLVRVTAEGSVEYFSSFEDLQIEQPMKEVQPNLIETMYRHRADLEIIFGMIDKDHSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGW4</accession>
    <name>A0A401QGW4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01069657">
        <property type="protein sequence ID" value="GCB84583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGW4"/>
    <dbReference type="STRING" id="75743.A0A401QGW4"/>
    <dbReference type="OMA" id="SEEMSWV"/>
    <dbReference type="OrthoDB" id="8964719at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="377" mass="37951" checksum="7578F656EDE0DB51" modified="2019-05-08" version="1" fragment="single">MSGVVSEEMSGTVSEEMSGTVSEEMSGAVCEMMSGTVSEVMSGAVSDVMSGAVSEAMSGVVSEVMSGAVSEVMSGVVSEELSGTVSEVMSGAVSEEMSGAMSGAVSEEMSGAVSEEMSAAVNEEMSGVVSKEMSGAVSELISGAVSDVMSGAVCEVMSGVVSEEMSGAVSEEISGAVSEEMSGVVGVEMSGTVSEEMSWVVSEEMSGMVSEVMSGAVSEEMSGKVSEEMSGMVSEVMSGAVSEEMSGAVSEEMSGAVSEVMSGVVSEVMSGAVSEGMSGTVFEEMCGTVLEEMCGTVSEEMSGAVREVMTGALSEEMSGTMSEEMSGKESEGMSGTVFEEMCGTVSEVMRGTVSEVMSGAVREVMTGALSEEMSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHR4</accession>
    <name>A0A401QHR4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01100522">
        <property type="protein sequence ID" value="GCB84900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHR4"/>
    <dbReference type="STRING" id="75743.A0A401QHR4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="7449" checksum="935F3D7E112F1275" modified="2019-05-08" version="1" fragment="single">ALTLDSDEDIMEKFISGLHEVFITFPKEVMTILLEVKVGHDPDVCGEITGEKGMGEAKANGVLLLTKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIJ6</accession>
    <name>A0A401QIJ6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01136610">
        <property type="protein sequence ID" value="GCB85163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIJ6"/>
    <dbReference type="OMA" id="PDISQYS"/>
    <dbReference type="OrthoDB" id="6142108at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026135">
        <property type="entry name" value="C6orf15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15817:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2300002M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15817">
        <property type="entry name" value="STG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="324" mass="35000" checksum="F1FA6068F243C26F" modified="2019-05-08" version="1" fragment="single">DISQYPSSSDPDISQCPRSSDPDISQYPSSSDPDISQYPSSSDPDISQYSSSSDPDISQYPSSSDPDISQYPSGSDADISQYPSSSDPDISQYPRSSDPDISQYPRSSDPDISQYPSGSVTDISQYPSSSDPDISQYPSSLDPDISQYPSSSDPDISQYPSSSDPDISQYSRSSGPDISQYSQSSDPDISQYPSSLGPYISQYPSSLDPDISQYPSSLDADISQYSRSSDPDISQYSRSSDPDISQYPSGSDPDISQYPSSSDPDISQYPSSSDPDISQYPSSLDPDISQYPSSLDPDISQYPSSSDPDISQYPSSLDVFSVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIK2</accession>
    <name>A0A401QIK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01129331">
        <property type="protein sequence ID" value="GCB85200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIK2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="6732" checksum="291F09F2C27FB63C" modified="2019-05-08" version="1" fragment="single">SAAVERAEVESGAVECAAAVSAAVECAAMERAAVERAEVERAAAESVAVERAAAESAAAERAAVESAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK65</accession>
    <name>A0A401QK65_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01206161">
        <property type="protein sequence ID" value="GCB85779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK65"/>
    <dbReference type="STRING" id="75743.A0A401QK65"/>
    <dbReference type="OMA" id="PAQCRRD"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="150" mass="16918" checksum="5FD1E0CDC68B6E99" modified="2019-05-08" version="1" fragment="single">TQPSVAETQPSVAETLPSVAETQPSAAETQPSDRDPGQCRRDPAQCDRDPAQCRRDPAQCRSDPAQCRRDPAQCRSDPAQCRRDPAQCRRDPFQCDRDPAQCRRDPAQCRRDPAQCRRDSAPCHRDPAQCRRDPAQCRRDPAQSRRDPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPH0</accession>
    <name>A0A401QPH0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01435705">
        <property type="protein sequence ID" value="GCB87228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPH0"/>
    <dbReference type="OrthoDB" id="8947651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="12973" checksum="F5951B5983524929" modified="2019-05-08" version="1" fragment="single">TGETDNPDAGAMDNPDAAAMDNPDAGAMDNPDTGETESPDAGETDNPDAGAMDNPDAGGTDNPDTGWTDNPDTGAMDNPDTGWTENPDTGETDNPDAGAMDNPDAGAMDNPDAGAMDNPDTGETESPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPS8</accession>
    <name>A0A401QPS8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0028035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01455252">
        <property type="protein sequence ID" value="GCB87332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPS8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13716" checksum="103267E57AF1C9EA" modified="2019-05-08" version="1">MELDTDTGNGAGYSHLEWSWLQTPGMELVTDTGNGAGYRQPPGMVLVTDRHREWSWLQTDTGNGAGYRQTPGMELDTDTSNGAGYRHREWSWIQTDTRNGASNRQTPGMELVTDRHQEWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGB7</accession>
    <name>A0A401NGB7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor TFIIB cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0011037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004891">
        <property type="protein sequence ID" value="GCB59973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGB7"/>
    <dbReference type="STRING" id="75743.A0A401NGB7"/>
    <dbReference type="OMA" id="RHCITED"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="234" mass="26097" checksum="436D2F9D03BA77B6" modified="2019-05-08" version="1">MHTGRRPSGLCGAALLVAARMHDFRRTVKEVIRVVKVCESTLRKRLNEFEETPTSQLTIDEFMKIDLEEECDPPSFTAGKRKIRLQQLEQELSKKLVDFEGEIASYQDEIETELEITRPRYRGAYATYAKGDALDDGASVTSSGLGEEEGEDEELTAVANHLNKDFCDDFLNEEQPKDNDKTEEKKELEPPPKPPNISSLLGPLPTAASLGLKESIEECIAADEPESSKDACFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGM9</accession>
    <name>A0A401NGM9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0012674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01006189">
        <property type="protein sequence ID" value="GCB60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGM9"/>
    <dbReference type="STRING" id="75743.A0A401NGM9"/>
    <dbReference type="OMA" id="KEAAQCW"/>
    <dbReference type="OrthoDB" id="10069378at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000001">
        <property type="entry name" value="Basic phospholipase A2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF4">
        <property type="entry name" value="GROUP 10 SECRETORY PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="84"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="107"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="130"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="207" mass="24042" checksum="87268C65F4E10314" modified="2019-05-08" version="1">MKGVNFQFLFNNSEIRGNDGVGGFKQLALVPDHLRQLENHQLILFPSLDLPALSSMESLHFSLFLLLSVHVTAVQEHHRRQARSIWDLAGMIRCSTKRSISYLMYGCHCGIGGKGRPKDGTDWCCFDHDCCYANAERAGCRPKSDSYNWYCRYNTPRCGFSFDHCKRMICECDMKLSLCLKKNVYWKRYALWPNFLCGRRKPHCYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIR4</accession>
    <name>A0A401NIR4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0009227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003710">
        <property type="protein sequence ID" value="GCB60747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIR4"/>
    <dbReference type="STRING" id="75743.A0A401NIR4"/>
    <dbReference type="OMA" id="GERRAHC"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF12">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB60747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="250" mass="28264" checksum="32FA0A8AA7B1DFE9" modified="2019-05-08" version="1">MFQLPILNFSPQQVAGVCETLEESGDIERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHTGNFRELYHLLENHKFTKESHGKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQILSQASVRSLSEEDAAVEPLVGASSPAASLCSVSERSKAATSAISITSSDSDCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ96</accession>
    <name>A0A401NJ96_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable ATP-dependent RNA helicase DDX41</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAD box protein 41</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0004029</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Identified in the spliceosome C complex. Interacts with ERCC6. Interacts with FAM50A. Interacts with STING1. Interacts with CGAS. Interacts with several spliceosomes components such as PRP19 or CDC5L.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01001152">
        <property type="protein sequence ID" value="GCB60958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ96"/>
    <dbReference type="STRING" id="75743.A0A401NJ96"/>
    <dbReference type="OMA" id="QMKMPII"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="223"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="418"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB60958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="633" mass="71376" checksum="650A8710C1F784F0" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKZ7</accession>
    <name>A0A401NKZ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0009358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003797">
        <property type="protein sequence ID" value="GCB61527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKZ7"/>
    <dbReference type="STRING" id="75743.A0A401NKZ7"/>
    <dbReference type="OMA" id="ALTHWGQ"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000010">
        <property type="entry name" value="Myosin regulatory light chain 2, atrial isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB61527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="192" mass="21718" checksum="47BB62A371172517" modified="2019-05-08" version="1" fragment="single">RLGMTWSIDICIQQQEHKMASRKAARGKASSKQNQRSSSNVFSMFEQSQIQEFKEAFGCIDQNRDGIISKQDLKETFVQLGKLNTKDEELEEMLKEGKGPMNFTVFLSLFGEKLNGSDPEETILNAFKLFDPQGTGHVNKDEFKTLLMSQADKFSAEEVQQMFAVTPIDVAGNIDYKSLCYIITHGDEKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM95</accession>
    <name>A0A401NM95_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0009434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003851">
        <property type="protein sequence ID" value="GCB61972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM95"/>
    <dbReference type="STRING" id="75743.A0A401NM95"/>
    <dbReference type="OMA" id="NLANDRP"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000174">
        <property type="entry name" value="cold-inducible RNA-binding protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB61972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="151" mass="16941" checksum="2DE5204AD083A275" modified="2019-05-08" version="1">MSDEGKLFVGGLNFDTDEQSLEQLFSKYGEVRDVLVIKDKDTHKSRGFGFVTFENPDDARDALAMNGKSVDGRQIRVDQAGKGSGGRSRNYQSGQSRSYGFRGGRGSRGFYRDGDRSGRSSYRNDYYNSYGYNSSAGKSYREDYDSYATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NME5</accession>
    <name>A0A401NME5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0014424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007735">
        <property type="protein sequence ID" value="GCB62019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NME5"/>
    <dbReference type="STRING" id="75743.A0A401NME5"/>
    <dbReference type="OMA" id="ENQCIYV"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="493"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="894" mass="99535" checksum="37137A12A4708654" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPJ8</accession>
    <name>A0A401NPJ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DDX54</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAD box protein 54</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0009584</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts in a hormone-dependent manner with nuclear receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01003941">
        <property type="protein sequence ID" value="GCB62811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPJ8"/>
    <dbReference type="STRING" id="75743.A0A401NPJ8"/>
    <dbReference type="OMA" id="QCHRESP"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000784">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="138"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="337"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB62811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="646" mass="73012" checksum="6C0DA5363FDAA484" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRB1</accession>
    <name>A0A401NRB1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007918">
        <property type="protein sequence ID" value="GCB63389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRB1"/>
    <dbReference type="STRING" id="75743.A0A401NRB1"/>
    <dbReference type="OMA" id="MSLKQNR"/>
    <dbReference type="OrthoDB" id="6158176at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="11447" checksum="72D6816214A72829" modified="2019-05-08" version="1">MSLKQNRRRRLMAPLGEVGNYLGVQDAIPFGNVPVLPVDNPVLLSDHLGQSEGGLSRGSVTDLAHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRQDHSRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRC0</accession>
    <name>A0A401NRC0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004006">
        <property type="protein sequence ID" value="GCB63399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRC0"/>
    <dbReference type="STRING" id="75743.A0A401NRC0"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB63399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="215" mass="24471" checksum="FCB8187A8F995C8B" modified="2019-05-08" version="1" fragment="single">HNPSQPAPNQCDEEVVEGDQMEVLDRVNKNDDQILAHLSPRLHQALIEACAEKRGFHAVFSNTLPVRLASAMMLPYTLPLESAVSFTIKMLEWLPDLPEDIDWMKGQIASILWYVVTNAKTKVGHHISTRLQNSTRLQKSQSLFILQAPSTYKSVKKWVRSNTSVMDLISKCEAYQRHLWLSLPLVNWNVQASLYQQDLDRGLEMKPSAVHGDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSN7</accession>
    <name>A0A401NSN7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0013259</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01006704">
        <property type="protein sequence ID" value="GCB63870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSN7"/>
    <dbReference type="STRING" id="75743.A0A401NSN7"/>
    <dbReference type="OMA" id="TVRWIDD"/>
    <dbReference type="OrthoDB" id="285418at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000049">
        <property type="entry name" value="Dual specificity protein phosphatase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020420">
        <property type="entry name" value="Atypical_DUSP_subfamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46495:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46495">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01910">
        <property type="entry name" value="ADSPHPHTASEB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB63870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="21421" checksum="F7C490CF4C036534" modified="2019-05-08" version="1">MNPHSTVKSISSLHSVQPTPRLWGLALITRNLYLSNAVASHNQSLLQASGVTCIINVTPEVISSMFPGIEYINIPVADSPSAQLKEYFDMVADKIHLVESLRGRTLLHCAAGVSRSPTLCLAYLMKYHQMSLLGAHAWLKARRPIIRPNSGFWKQLIEYEDGLFGKTSIKMVMSPLGVIPDIYEEETRGMIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTR5</accession>
    <name>A0A401NTR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008032">
        <property type="protein sequence ID" value="GCB64266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTR5"/>
    <dbReference type="STRING" id="75743.A0A401NTR5"/>
    <dbReference type="OrthoDB" id="448492at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000086">
        <property type="entry name" value="Cold shock domain-containing protein C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052069">
        <property type="entry name" value="Ca-reg_mRNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962">
        <property type="entry name" value="CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962:SF3">
        <property type="entry name" value="CALCIUM-REGULATED HEAT-STABLE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="175"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB64266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="256" mass="27820" checksum="E0B281F1A91B0F1C" modified="2019-05-08" version="1">MNGVWPSFVSVLPDHASWKPLLVAHHVRASENEFSEVTAAPAAVALMWEAGGCHEDSRGVKAAMRVAKSTVDAVSGLRVKLYVVFLTVEKPEAALHVWKKLWWARPIITSQSTSPQSPASSQPLSPSSAALHTPENTRIRERSPSPMRGFLIPSPLPTRRTRTMSATARAAEGPVFKGTCKCFSRCKGHGFILPADGGAEIFVHISDIEGEYVPMEVSYKVCSIPPKNEKIQAVEVVITHQAPGTKHETWSGHATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU37</accession>
    <name>A0A401NU37_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002750">
        <property type="protein sequence ID" value="GCB64411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU37"/>
    <dbReference type="OrthoDB" id="9624097at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="124" mass="14120" checksum="E1FF6BDD4B1EA888" modified="2019-05-08" version="1">MEKTNSPIAANSESSTEEISESDSLDSEVQLEMEPYLVRRLSFHALQLPPLAFRLAEQYDWERKSETEHIPRPTTLPLKTLPLIAITAADNSRTEIDYEGTADEDGYIQNPAHRDSWPLKVVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUZ4</accession>
    <name>A0A401NUZ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cyclin-dependent kinase 5 activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0007577</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4. Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Heterodimer of a catalytic subunit and a regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Endomembrane system</location>
            <topology evidence="17">Lipid-anchor</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002778">
        <property type="protein sequence ID" value="GCB64711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUZ4"/>
    <dbReference type="STRING" id="75743.A0A401NUZ4"/>
    <dbReference type="OMA" id="IKKTPHP"/>
    <dbReference type="OrthoDB" id="7676799at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000025">
        <property type="entry name" value="Cyclin-dependent kinase 5 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009324">
        <property type="entry name" value="Cdk5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB64711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="302" mass="33851" checksum="7C9E7FFB4A8639EC" modified="2019-05-08" version="1">MGTVLSLSPSYKKAPLYEDGSASVGQYTAVQNSKNSKEKNGKRHSIISVLPWKRIVAVSSKKKNSKKVNPNNYQNNVTHLNNENLKKSLSCANLSTFAQPQAPVQRTSQQLPSSKSNISSVKTPHNGSVSSISPKRVIVQASTSELLKCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFVTPANVVFVYMLCRDVISSEVATEHELQATLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSIINAMSGKMLQINADPHFFTQIFADLKKESNQDDRGRILIGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVB1</accession>
    <name>A0A401NVB1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002785">
        <property type="protein sequence ID" value="GCB64784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NVB1"/>
    <dbReference type="OMA" id="NINTHDM"/>
    <dbReference type="OrthoDB" id="8447576at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052466">
        <property type="entry name" value="DNA_MethProtect_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14709:SF2">
        <property type="entry name" value="GLUTAMINE AND SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14709">
        <property type="entry name" value="GLUTAMINE AND SERINE-RICH PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="1585"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="531"/>
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        <location>
            <begin position="532"/>
            <end position="547"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="554"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1794" mass="196841" checksum="CE2BEBFE6725F123" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXR3</accession>
    <name>A0A401NXR3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Glutathione synthetase</fullName>
            <shortName evidence="15">GSH-S</shortName>
            <ecNumber evidence="4 15">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0013487</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:72075"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:189406"/>
            <dbReference type="ChEBI" id="CHEBI:189750"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:72076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4 15"/>
    <dbReference type="EMBL" id="BFAA01006909">
        <property type="protein sequence ID" value="GCB65671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXR3"/>
    <dbReference type="STRING" id="75743.A0A401NXR3"/>
    <dbReference type="OMA" id="FEAHKNM"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="18">
        <location>
            <begin position="224"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="419"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB65671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="483" mass="54319" checksum="F164A734D539807B" modified="2019-05-08" version="1">MYGRLPSLSLPRRADGEVILPPVAPDDVLHNSGLIQQLAVAAKDAALLRGVLMRTKEDPSSTESTSYAPFSLFPSPVPKKLFTEAYEVQQDFNMLVDRISQDSEFLTKALASTVQVDEFTAGLFSIYKQVLEEGITQTITLGINRSDYMFDRGQDHSTSLKQIEINTIAASYAGLAERVPDVHRHVLNFWGKSDEAAKILTNNAVKGIAEGIAKAWQLYGSPEAVVLFLVEKVSRNIFDQRCLEMELWYKNIRVIRRQTLDIYERGSLDDEKRLFVDGYEIAIAYFRTGYSPEDYHNDDCWVARLLIERSKAIKCPDIATHLAGTKKIQQELARSGMVEKFLTDCPKSAERIRATFVGLYSIDEGPEGDEIIKKAVEDPEGFVLKPQREGGGNNIFGEELKQLLGNIKDGPKRSAYILMDRIKPQTVKNYLLHPGSALKLSECVVELGVFGVYIRPILVTAKLVYQTRTMSQLPRSEKEREMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYE5</accession>
    <name>A0A401NYE5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aspartate dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the L-aspartate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005606">
        <property type="protein sequence ID" value="GCB65870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYE5"/>
    <dbReference type="STRING" id="75743.A0A401NYE5"/>
    <dbReference type="OMA" id="LAFIWNR"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011182">
        <property type="entry name" value="L-Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873:SF6">
        <property type="entry name" value="ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873">
        <property type="entry name" value="L-ASPARTATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="Asp_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005227">
        <property type="entry name" value="Asp_dh_NAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate dehydrogenase" evidence="3">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="256" mass="28840" checksum="1C5EFA0B3528A7D9" modified="2019-05-08" version="1">MKSMPPRKTRITAHRSLLRRVSQQRPRGKISPEASMAQERNVRRIGIIGFGHLGQYLAGMIEEEGHQHGFELAFVWNRHQKKMDGNVRKELQLEDLNKFVARCADLIVEVAHPQIIKDYGEEFLKHADCMVGSPTAFADQEVDTRCREAARRYGHTLYIPSGALWGALDIQKMANRGTLKALKVTMSKHPDSFMLQGHMHELKERTKGQRTVLYDGPVRNLCPLAPNNVNTMAAAALAGHNLGFERVQGCLVADPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYG0</accession>
    <name>A0A401NYG0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004240">
        <property type="protein sequence ID" value="GCB65894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYG0"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="7605" checksum="F10D58A05638CFFE" modified="2019-05-08" version="1">MGKVVILLVKDIYYPILAAFGLPANLMTIVILSRGNCGLSKCITAYMGEKYNIIPETQYRYSGDQKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ36</accession>
    <name>A0A401NZ36_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0007830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002906">
        <property type="protein sequence ID" value="GCB66136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ36"/>
    <dbReference type="STRING" id="75743.A0A401NZ36"/>
    <dbReference type="OMA" id="IRCCDTE"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF24">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB66136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="159" mass="17666" checksum="45E30518D0ED382D" modified="2019-05-08" version="1">MEKLRRVLSGQDDEEQGLTAQVLDSTSLSFGTRVKWFAICFAVGVCCSILGTILLWLPNGIKLFAVFYTLGNIAALSSTCFLMGPLKQLKKMVDPNRLIATIVMLVCFILTLCAVFWWQKKGLALLFCVLQFLATTWYSLSYIPFARDAVIKCCTSCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZK3</accession>
    <name>A0A401NZK3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shootin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002922">
        <property type="protein sequence ID" value="GCB66285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZK3"/>
    <dbReference type="OrthoDB" id="6129359at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028227">
        <property type="entry name" value="UPF0449"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15136">
        <property type="entry name" value="UPF0449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14301" checksum="F7506ACDC2144A84" modified="2019-05-08" version="1">MTWRGRGIRRRRRDSDSRMRRCYDVKKQEASEGCEELLTPARAAVSMPDVETQYQQSKAYVELNQHLQEELSELASQSEELKKAEELLDLSISEIKEKNFQNWGYVLTDGSPESSQLGGTLFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P066</accession>
    <name>A0A401P066_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kringle-containing protein marking the eye and the nose</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0012018</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005673">
        <property type="protein sequence ID" value="GCB66497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P066"/>
    <dbReference type="STRING" id="75743.A0A401P066"/>
    <dbReference type="OMA" id="RACYWTI"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF26">
        <property type="entry name" value="KRINGLE-CONTAINING PROTEIN MARKING THE EYE AND THE NOSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 11" id="KW-0420">Kringle</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="15">
        <location>
            <begin position="33"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="131"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB66497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="328" mass="36111" checksum="8CB55FB356B925BA" modified="2019-05-08" version="1">MKNPDNDVRPWCYVAEYEDGVYWKYCDIPTCHMPGYLGCFKDNGDPPPLSGSSETSNKLTIQTCITFCRSKRFKLAGMESGYACFCGNDADYWKHGEANSTECNHVCFGDHTQPCGGDGRINIFDAMIGACGGNYSTDAGIIYSPDFPDNYASGRVCYWTIQVAGASLIRFDFALFDIQDSSDMVEFLDGRSNDVLARFDGRNRPYDSLNVSASFVILYFYSDRVNQAEGFAVLYKAIKDSPRAQPPASKNDINASDVITERVGPGTNAARSSKILYFITASPSQSNQNMPVWTIYALAALLTLTAVAMVSKILLHLTVKKTVPTSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0M5</accession>
    <name>A0A401P0M5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0000625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000119">
        <property type="protein sequence ID" value="GCB66669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0M5"/>
    <dbReference type="STRING" id="75743.A0A401P0M5"/>
    <dbReference type="OMA" id="TYDRMYT"/>
    <dbReference type="OrthoDB" id="5843397at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008037">
        <property type="term" value="P:cell recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042271">
        <property type="term" value="P:susceptibility to natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05881">
        <property type="entry name" value="IgV_1_Necl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000013">
        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000184">
        <property type="entry name" value="cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF2">
        <property type="entry name" value="CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="120"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="228"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB66669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="419" mass="46514" checksum="2DB2329B41D53D3D" modified="2019-05-08" version="1">METLSIFVKPRAAQEIEADAQNLVTDDVEVVEGEVATISCRVKNNDDSVIQLLNPSRQTIYFRDVRPLKDNRFQLVNFSSSELRVSLSNVSLVDEGRYCCQLYTDPPQEAFATITVLVPPETPTIDANKDIVSEGEEVEFTCSATGSKPAASIKWLKGDQEMRESTGNVEEDPREEKLFNVTSKLVLKVSRLDDGLPITCKVDHPAVKDIQTMKDLQAQRYLDVQYKPQVQVTRSYPQGLTREGDTLELVCTANGKPQPKLTWQRLEEEVPDRAILTENLVLESLNKTDNGTYRCKAFNDVGESYDDYVLYVYDAPTTIPPPTTTTTTTTTIPTITEDSRAGTEVPRSVDHAVIGGVVAVVVFAILCLLIVLGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSDEKKEYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0N0</accession>
    <name>A0A401P0N0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Chromosome region maintenance 1 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0015033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008322">
        <property type="protein sequence ID" value="GCB66686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0N0"/>
    <dbReference type="STRING" id="75743.A0A401P0N0"/>
    <dbReference type="OMA" id="TSETICK"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001255">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB66686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="988" mass="113392" checksum="DDC4AA2DB9E8B896" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P118</accession>
    <name>A0A401P118_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0015050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008341">
        <property type="protein sequence ID" value="GCB66852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P118"/>
    <dbReference type="STRING" id="75743.A0A401P118"/>
    <dbReference type="OMA" id="HIFFQHG"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000002">
        <property type="entry name" value="F-box only protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="3">
        <location>
            <begin position="67"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB66852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="30138" checksum="63D5C7EFDB12D51E" modified="2019-05-08" version="1" fragment="single">PPPRPSQRMATLEDLHEDVLAEILCHVPGKDLILNCRLVCRLWRELVDRTHIWKEKCIRERAFKRNFHFTTPNDWMKLYFIPLAVNLIKNPSAEEDFRFWSIDESGGDDWKVETLPGGHGQNHPNKILNKYFVTSYQLCRKSQIIDLSTHGLWSSLLDFIQPKIVVSDWYAARHDCGCVYALEVELLSKDRTAICSYKSEEITIPQWSDAKWNQITHVFENYGPGVRYVHFSHEGRDTQFWAGWYGVRVTNSSVTVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P179</accession>
    <name>A0A401P179_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MORN repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000126">
        <property type="protein sequence ID" value="GCB66871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P179"/>
    <dbReference type="STRING" id="75743.A0A401P179"/>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36200" checksum="2C660C6773403E2C" modified="2019-05-08" version="1" fragment="single">NGDHYQGDWVLDRRQGHGILQYADRSLYEGQWRNDLFNGQGSMIHCSGVTYDGMWINGRPATEATKLVILGEGIQEVVQGSPFTIEVQLQNNEGELTKAENGRVLQIWAGVKHIKLSLTGSDTFLEMVDLEESLFETPFGFDAIRYPLMEYVPEPDKVKGSSADSSRSEITTVGSLGTGDSDVNESKLDLVAATGKPQDSLHDTPDPSPVNKERGTNQEEEALYGSQLYPGAEKDSIPALANQRAESGSAAFWNIALAGPPASYRPFMILDELEKKTSKKLSSRALSDRTTVSQEKISESRWVLQLNQYKSLCVALNSMPCAWGEAASSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P195</accession>
    <name>A0A401P195_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0005044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001531">
        <property type="protein sequence ID" value="GCB66877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P195"/>
    <dbReference type="STRING" id="75743.A0A401P195"/>
    <dbReference type="OMA" id="LIWEQRT"/>
    <dbReference type="OrthoDB" id="418634at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090557">
        <property type="term" value="P:establishment of endothelial intestinal barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905605">
        <property type="term" value="P:positive regulation of blood-brain barrier permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06727">
        <property type="entry name" value="PDZ1_ZO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865:SF11">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN ZO-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="291" mass="32921" checksum="5B5CAC0C14BEC36E" modified="2019-05-08" version="1">MAVRFQDQSVEMEETLIWEQRTVVINRDSKKGFGIAISGGKDKPNVSTGETAILISDVVRSGPAEGKILIKDRIVMVNGISMDNVPSSVAIQCLKSSGKSAKITVKRPCKVQIPVTNRASATSYHSSRSDYVHDDASDEDEDYDPADRRLRRIQNQNLYHDDYHHSSDYDRDSGRNDSYDRSPSPSRSYNRSPSPSRRHDRSPSPSRRHDRSPSPSRNYNHQQKKQDYHSREHIREQSPAGNYHDDLEQPDSQYDSNATKKPIKSFLIKNNANEGEISVNGKPEIQVGNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1C6</accession>
    <name>A0A401P1C6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0012075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. BTN/MOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005718">
        <property type="protein sequence ID" value="GCB66928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1C6"/>
    <dbReference type="STRING" id="75743.A0A401P1C6"/>
    <dbReference type="OMA" id="GTPIFIC"/>
    <dbReference type="OrthoDB" id="9986391at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="88"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="9">
        <location>
            <begin position="299"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB66928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54523" checksum="2F8CCFEF8A7920B1" modified="2019-05-08" version="1">MSAVGFISPPSGRLYPSGVSSWSNHVWEALVVGIITASVTSWIAYRQRRLDSPRSDRRVSLPAELLLQVAILAGAVFASYLNGSQRGPFTVKGPDSLTVAHLGEDVVLSCLVVPFRQDMKLWVEWKDLDTGATILTCESDRTEQCLALGGRAHLFVGQPPAGNMSIGLRGVKESDAGTYRCTVSSNGHSSHVDMELAMVAFGRKPGLSITQSDESVVAYACQSEGWYPEPDIIWKDSFGNSLVPLSTVTKVRDEQGLYNVDIQYRTTDSVSSTVTCIIYNKLGNVKKMSTAYVVDFLPHAQFRVSEAEWSRIRSFQVSLTLDPDTANPWLILSEGGTSVSDSNERQHLPENPERFLVSHCVLASEGFAAGKRYWETEVGQKETWDLGLASETVSRKGKVKGVPGAGHWSLSHLSKTEYQTVDSPPRTLPLGQNPTVVGVYLNYERGQVSFFDAGGQLHLYTFAANFTERLYPFFCPGLHNWQKNAEPLHLRNPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1F9</accession>
    <name>A0A401P1F9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0015062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008358">
        <property type="protein sequence ID" value="GCB66956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1F9"/>
    <dbReference type="STRING" id="75743.A0A401P1F9"/>
    <dbReference type="OMA" id="MRWQVYA"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF17">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB66956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="180" mass="20717" checksum="66C8E3CB5E8D7F1C" modified="2019-05-08" version="1">MSDRPRGAARRRGQTPRRRSPLRVSPEPSPQRRRSPGRSPPGRSPARSARGRRTLTSPRRRSPVRQLRRPGDGPPPQRRRFRPGTRALMEIRKYQKTTDLLIRKLPFSRLVREVACRFTRGIHFRWQANALLALQEASEAFLVLLLEDANLCTLHAKRVTLFPKDVQLARKLRGIQEGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P352</accession>
    <name>A0A401P352_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003029">
        <property type="protein sequence ID" value="GCB67541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P352"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="96" mass="10954" checksum="6FFFB1D8EBD13D7B" modified="2019-05-08" version="1">MEAALKPDKLSLDPHAPRADHLFNCWLQCFEAYLEASSAFAKTDADRLNLLYSRHDYGLFDLITGTTTYADAIVKLKSRWTIFGFRVLLLAHDSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3K7</accession>
    <name>A0A401P3K7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Acetylcholine receptor subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0008102</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Pentamer of two alpha chains, and one each of the beta, delta, and gamma chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003046">
        <property type="protein sequence ID" value="GCB67712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P3K7"/>
    <dbReference type="STRING" id="75743.A0A401P3K7"/>
    <dbReference type="OMA" id="RKMINTR"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19029">
        <property type="entry name" value="LGIC_ECD_nAChR_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000048">
        <property type="entry name" value="Cholinergic receptor nicotinic epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000010">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000012">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022272972" description="Acetylcholine receptor subunit gamma" evidence="20">
        <location>
            <begin position="18"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="242"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB67712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57979" checksum="C53FF830F5E41D14" modified="2019-05-08" version="1">MALPLLLTFGLLLGVRSNVEEKLLNTLMANYDKRILPAKFYGDIIDVTLKLTLTNLISLNEKEETLATNVWIEIQWSDYRLSWNTSDYAGVDLVRIPSSMVWLPEIVLENNVDGQFEIAYYANVLVSNMGSIFWLPPAIYRSACPIAVTYFPFDWQNCSLIFRSQAYNAREINLILSEEEGQLIEWIHIDPEDFTENGEWTIKHKPAKKNINSQFTVDDIEYQEIIFFLIIQRKPLFYVINIIIPCVLISSLVVLVYFLPAQAGCQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLIGKYLIFVMIVCTSIVTNCVIVLNVSLRTPNTHSMSEKIKHVFLELLPQYLGMHLEASEDSWDTPQPRRRSSFGIMLKAEEYILKKSRSELMFERQRGRHGLKRLDKATAGADIDIGTTVDLYRNLAHFAPEIKTCVDACNFIAKSTKEQNDFGSENENWILIGKVIDKACFWIALLLFFIGTVTIFLTGHFNLAPEFPFAGDPRKYAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4S6</accession>
    <name>A0A401P4S6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0008179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003081">
        <property type="protein sequence ID" value="GCB68096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4S6"/>
    <dbReference type="STRING" id="75743.A0A401P4S6"/>
    <dbReference type="OMA" id="HEMITLA"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF26">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB68096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="363" mass="40998" checksum="4546D05AA5152AE4" modified="2019-05-08" version="1">MSRKHPASDVNESSVAAKKTRKTITLEMKLEVLKRFEAGERAVAIGRALGLPPTTVRTIRGNTDKIKQSAQSVAPLSAGRISRTRSSIMENMERLLEVWIKDQNQRNVPLSLMVIQTKAKSFFNDLQNEQGGSSQSESFSASRGWFERFKKRSCLHNIKVTSEAAIAAVDEFPSQLKRIIEEGGYSPKHVFNFEAGLSWKRVPQRTYISKEEKAECASNHRGSFDIVPEVQHEMITLAREVGFDEVEEANMVESLVSHGEKSTSEDLMQLESQPVEDEVGAETSSPRVLSTKRLSRAFQLIEEAMEIFTESDPNKERSAKVNRAINDGISCYKEIYRLKKKETVQQSLDKFFKDIDDPGRLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5G4</accession>
    <name>A0A401P5G4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrroline-5-carboxylate reductase catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0012267</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71771"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:71773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:71769"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the STEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005870">
        <property type="protein sequence ID" value="GCB68336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5G4"/>
    <dbReference type="STRING" id="75743.A0A401P5G4"/>
    <dbReference type="OMA" id="RENIMPD"/>
    <dbReference type="OrthoDB" id="550646at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008823">
        <property type="term" value="F:cupric reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000051">
        <property type="entry name" value="STEAP2 metalloreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239:SF8">
        <property type="entry name" value="METALLOREDUCTASE STEAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="22">
        <location>
            <begin position="95"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="21">
        <location>
            <begin position="323"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB68336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="63348" checksum="85B94B4CA776EB1F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6Y6</accession>
    <name>A0A401P6Y6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCSER family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000197">
        <property type="protein sequence ID" value="GCB68884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6Y6"/>
    <dbReference type="OrthoDB" id="10046062at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029627">
        <property type="entry name" value="CCSER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22461:SF1">
        <property type="entry name" value="SERINE-RICH COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22461">
        <property type="entry name" value="SERINE-RICH COILED-COIL DOMAIN-CONTAINING PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB68884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="9242" checksum="E1D9E5F6BD264282" modified="2019-05-08" version="1">MLSQDVLNRLGSCDLDEDDLMLDLEFLEDQRHQSDNTATKHFVCHEDFNHSIKSCVEILHVPAELKMKFEGTKVPETPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P761</accession>
    <name>A0A401P761_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000200">
        <property type="protein sequence ID" value="GCB68956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P761"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="78" mass="8821" checksum="9E678D0CB416E632" modified="2019-05-08" version="1">MGHSLTSSFSSEVRKQLKETLSRMQRDHKSSAEELSVNVTLNDKASEVVRTKQTIAFKNSQTSCNMNTNGAWEQLTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7Y7</accession>
    <name>A0A401P7Y7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0005440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001691">
        <property type="protein sequence ID" value="GCB69228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7Y7"/>
    <dbReference type="STRING" id="75743.A0A401P7Y7"/>
    <dbReference type="OMA" id="GDAITWP"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000475">
        <property type="entry name" value="Olfactory receptor C family, g2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000752">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF528">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00592">
        <property type="entry name" value="CASENSINGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019266502" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="12">
        <location>
            <begin position="18"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="13">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="13">
        <location>
            <begin position="134"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="GPCR family 3 nine cysteines" evidence="14">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="13">
        <location>
            <begin position="503"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="GPCR family 3 nine cysteines" evidence="14">
        <location>
            <begin position="769"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB69228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="97175" checksum="CE1D82A0931DF76E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P888</accession>
    <name>A0A401P888_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with eif4g1, eif4g2 and slbp; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with eif4g1 which is bound to their 5'-end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MIF4GD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003189">
        <property type="protein sequence ID" value="GCB69359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P888"/>
    <dbReference type="STRING" id="75743.A0A401P888"/>
    <dbReference type="OMA" id="VNDWVCL"/>
    <dbReference type="OrthoDB" id="6357832at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF17">
        <property type="entry name" value="MIF4G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="219" mass="25451" checksum="3823D92529296E4A" modified="2019-05-08" version="1">MHCGGCGWGFRQRNVKSFCDSCFTEPASVDLEKVASVIIEQSMKDLVFSKEAGRICYTIVQAENKQSGNSNFRRNILTRLQQEFLLKEQLRERSVNDWVCLVTFICNIFDYLKVNNMPMMALVNPVYDCLMRLTHPDSLQNEEEVDCLVLQLHRIGEQLQKMNAQRMDELFCQLRDGFLLLHQPSSLSRLLLLEIIEFRAGGWKMSENAQKYYYSEVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9M4</accession>
    <name>A0A401P9M4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 235</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0005544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001738">
        <property type="protein sequence ID" value="GCB69790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9M4"/>
    <dbReference type="OrthoDB" id="9626630at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039951">
        <property type="entry name" value="TMEM114/TMEM235"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20516">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 114/235 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20516:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB69790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17446" checksum="62A1DF810A61424A" modified="2019-05-08" version="1">MQKGEDCSDKGTSPATLSDIWNRMTVGIVCLTAGLTGLSSFVFLTVAIGTDYWYVIDVSNSRYSYGEDWEDLNSHSGLWRICEGKNACIALIDPFGEESQNVPESQRHLLLMQKVFVILLPLSLVVLVIGGICGLVSSLAHGLYMLLFTGSYFLVGGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAF0</accession>
    <name>A0A401PAF0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006084">
        <property type="protein sequence ID" value="GCB70070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAF0"/>
    <dbReference type="STRING" id="75743.A0A401PAF0"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF277">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="20418" checksum="90C134D43DBE6D2F" modified="2019-05-08" version="1">MTTHARRGKSPRVLQQVKYDLATAMASHRVQLSRRMSQASSDSRSPRLCRRRPNTCCFCWCCCCSCLTVRNKDKHDCSRRSSIISQMESLQKHEESLSLEEVTAWSQSFEQLLKHRTGRNILMEFLQSEHSDENILFWLACEELKQEDHKATIAEMAKSIYLDYISILSPKEVSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAX6</accession>
    <name>A0A401PAX6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of cell cycle RGCC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000268">
        <property type="protein sequence ID" value="GCB70276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAX6"/>
    <dbReference type="OMA" id="EVCQYEQ"/>
    <dbReference type="OrthoDB" id="9887289at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029252">
        <property type="entry name" value="RGCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32193">
        <property type="entry name" value="REGULATOR OF CELL CYCLE RGCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15151">
        <property type="entry name" value="RGCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12371" checksum="DF2AF2949EF7655C" modified="2019-05-08" version="1">MDSNDAVNSVWNENEFDALLNEFNTVMEDLSCSTNNGVQYEEHLNQMKKMSTANAADSGIDDSDSTGSSAGSSLNCSIEKLNSVDTTTSKAKLGDTRDLEDFIADLDQTLAEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB37</accession>
    <name>A0A401PB37_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004698">
        <property type="protein sequence ID" value="GCB70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB37"/>
    <dbReference type="STRING" id="75743.A0A401PB37"/>
    <dbReference type="OMA" id="TSMEEQH"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000008">
        <property type="entry name" value="rho guanine nucleotide exchange factor 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF49">
        <property type="entry name" value="KALIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="226"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="43884" checksum="83561D80953EFE2E" modified="2019-05-08" version="1" fragment="single">VLEPGCCFLTNLKDHFGFNSMNSSKPPHDEEKQAKAIKGTKYVLNELVQTEKVYVKDLGAVIEGFMKKMEEKGIPDDMKGKDKIIFGNLQQIYEWHKNYFSGELEKCLQEPDHLAKLFIKHERRLDMYSVYCQNKPKSEYIVVEYDAYFEEVKLDLGETFSLSDYLIKPVQRITKYQLLLRDFLKYSEQAGIECSEIMKAVDVMYHVPKRCNDLMNLGRLEGFKGKLTAQGKLLQQDTFYVTEEDSGVLSRSKERRVFLFEQVLIFSELLNKSSSTPQYQFKNSIKITNLHIEDNVDNEVCKFALRSQGTSERFILRAADSGICQAWVHDINKVLDMQQRFLTALQSPIDYQRKELAWKQIHTNQDLGKGSNALLNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB63</accession>
    <name>A0A401PB63_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neuroendocrine convertase 2</fullName>
            <ecNumber evidence="14">3.4.21.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Prohormone convertase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Proprotein convertase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0001251</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.</text>
            <dbReference type="EC" id="3.4.21.94"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.94" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01000274">
        <property type="protein sequence ID" value="GCB70349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB63"/>
    <dbReference type="STRING" id="75743.A0A401PB63"/>
    <dbReference type="OMA" id="LAKQWHS"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000020">
        <property type="entry name" value="neuroendocrine convertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000004">
        <property type="entry name" value="Proprotein convertase type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF13">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 19 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 19 20" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 19 20" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019175474" description="Neuroendocrine convertase 2" evidence="21">
        <location>
            <begin position="26"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="22">
        <location>
            <begin position="462"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="18 19">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="18 19">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="18 19">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB70349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="639" mass="70473" checksum="8E72794965AAA154" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBC7</accession>
    <name>A0A401PBC7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Nuclear receptor subfamily 1 group D member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0001275</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the msl-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000279">
        <property type="protein sequence ID" value="GCB70420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBC7"/>
    <dbReference type="STRING" id="75743.A0A401PBC7"/>
    <dbReference type="OrthoDB" id="7634782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07166">
        <property type="entry name" value="NR_DBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000047">
        <property type="entry name" value="male-specific lethal 1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000013">
        <property type="entry name" value="Nuclear receptor subfamily 1 group D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2000">
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="1066" mass="119344" checksum="3F876764E96CB022" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
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            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
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                <person name="Adachi N"/>
                <person name="Nishimura O"/>
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                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="GCB70929.1"/>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDZ3</accession>
    <name>A0A401PDZ3_SCYTO</name>
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        <recommendedName>
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        </recommendedName>
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    </gene>
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        <lineage>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004856">
        <property type="protein sequence ID" value="GCB71338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDZ3"/>
    <dbReference type="STRING" id="75743.A0A401PDZ3"/>
    <dbReference type="OMA" id="CNELWIA"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000150">
        <property type="entry name" value="Glucosidase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019001950" description="EF-hand domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB71338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="384" mass="42998" checksum="42BFC48A06C7F7D8" modified="2019-05-08" version="1">MAVPVSLLLAARSLLLLSLSSAAAVEVKRPQGVSLSNRHFYDEYRPFTCLDGSKTIPFDEVNDDYCDCKDGSDEPGTSACPNGSFHCTNAGHKPQYIPSSRVNDGICDCCDTTDEYNSGASCENTCKEQGRKEKETLQKMAEIAKEGLLFKQQLIEEAKRSRQDKQQALTDLQKKKETWEANVESLKAVKEAVEKPELEAKEIHKKAWDEVQAARKLEKEKAKAAETFKELDDDEDGFVSISEIQTHPELDSDGDGVVSEQEAESVLGGVRQVDVTSFRDAIWAGIQDKYKSEAAVEIPTLPEIPAEEVEDGHSTPHREEWKKDDRDEDDDDGGGEEHDDDGDEDEEEEEGGEEDYKHHVTRKNSDPNIKPWDPLRILLVRRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEZ6</accession>
    <name>A0A401PEZ6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001966">
        <property type="protein sequence ID" value="GCB71668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEZ6"/>
    <dbReference type="STRING" id="75743.A0A401PEZ6"/>
    <dbReference type="OrthoDB" id="6088188at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="233" mass="25751" checksum="352FBC5738722B83" modified="2019-05-08" version="1">MANALTSLYSHVSKTPVQKIGPAHQFSFSPDKSIGGASNKQHERKQPAGKAVQKLRKTITKLCLYGASRDLESPKHKTGSPSRKSPGLELSGELSLKAKSAKTEVQGLGTVCKQAFNSRDSGSPQPKGEGDQKPNSAKIKEMWREDTGRSRLYGFSTESDQSWEMEFHSKQEHSNPVPIDSSDTVWSCGEIVKQPIDIQEIKPISFHWTSQSSSEESEALKHDLNLHTDPEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFU6</accession>
    <name>A0A401PFU6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Jumonji</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Jumonji/ARID domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0001775</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000411">
        <property type="protein sequence ID" value="GCB71978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFU6"/>
    <dbReference type="STRING" id="75743.A0A401PFU6"/>
    <dbReference type="OMA" id="XFNGSTR"/>
    <dbReference type="OrthoDB" id="8951118at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16870">
        <property type="entry name" value="ARID_JARD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000007">
        <property type="entry name" value="Jumonji, AT rich interactive domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000005">
        <property type="entry name" value="Jumonji, AT-rich interactive domain 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF113">
        <property type="entry name" value="PROTEIN JUMONJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjN" evidence="14">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="13">
        <location>
            <begin position="622"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="15">
        <location>
            <begin position="880"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="195"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1199"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1224"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB71978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1239" mass="137674" checksum="E67295645D79C773" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG12</accession>
    <name>A0A401PG12_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyroglobulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0001814</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Monomer. Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus. Homooligomer; disulfide-linked; stored in this form in the thyroid follicle lumen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000423">
        <property type="protein sequence ID" value="GCB72072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PG12"/>
    <dbReference type="OMA" id="SIYVPQC"/>
    <dbReference type="OrthoDB" id="6409105at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006590">
        <property type="term" value="P:thyroid hormone generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052001">
        <property type="entry name" value="MHC-II_Gamma/Thyroglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093">
        <property type="entry name" value="HLA CLASS II GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093:SF19">
        <property type="entry name" value="THYROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-0405">Iodination</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0765">Sulfation</keyword>
    <keyword evidence="11" id="KW-0795">Thyroid hormone</keyword>
    <keyword evidence="5" id="KW-0893">Thyroid hormones biosynthesis</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="467"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="521"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="787"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="940"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="1018"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="1342"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="16">
        <location>
            <begin position="2018"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="908"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1053"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB72072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2289" mass="255122" checksum="27B583B1E838F755" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG80</accession>
    <name>A0A401PG80_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0001839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000428">
        <property type="protein sequence ID" value="GCB72136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG80"/>
    <dbReference type="STRING" id="75743.A0A401PG80"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000001">
        <property type="entry name" value="Clustered mitochondria (CluA/CLU1) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002593">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="362"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB72136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127569" checksum="A12DC85B695574E4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGG1</accession>
    <name>A0A401PGG1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002053">
        <property type="protein sequence ID" value="GCB72230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGG1"/>
    <dbReference type="STRING" id="75743.A0A401PGG1"/>
    <dbReference type="OMA" id="CANGLHE"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053080">
        <property type="entry name" value="PP1_regulatory_subunit_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46899">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46899:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="16669" checksum="FC59A6899746F542" modified="2019-05-08" version="1">MKYYSAAVSRYPAVSLPSARTVRFPNDIVFQDHIRQGDLEQVGRFIRARKVKLDTVYLSGMAALHEAVLSGNLECVKLLIKYGADIHQKDENGWTALHISCSDGHIEVAKYLLSQGARVDIVNDNGEVPMDLIDPEDVKLRALFELRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGJ7</accession>
    <name>A0A401PGJ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">GalNAc alpha-2,6-sialyltransferase VI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">ST6GalNAc VI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Sialyltransferase 7F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0001896</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-O-[alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-seryl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65280"/>
            <dbReference type="Rhea" id="RHEA-COMP:16760"/>
            <dbReference type="Rhea" id="RHEA-COMP:16761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:156395"/>
            <dbReference type="ChEBI" id="CHEBI:156397"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:65281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-O-[alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65284"/>
            <dbReference type="Rhea" id="RHEA-COMP:16762"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:156396"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:65285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acyl-sphing-4-enine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)]-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acyl-sphing-4-enine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:88073"/>
            <dbReference type="ChEBI" id="CHEBI:88079"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41972"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78445"/>
            <dbReference type="ChEBI" id="CHEBI:78571"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41973"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:78569"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41976"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78452"/>
            <dbReference type="ChEBI" id="CHEBI:78572"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41977"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a globoside MSGG + CMP-N-acetyl-beta-neuraminate = a globoside DSGG + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:140623"/>
            <dbReference type="ChEBI" id="CHEBI:140624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:56089"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000443">
        <property type="protein sequence ID" value="GCB72257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGJ7"/>
    <dbReference type="STRING" id="75743.A0A401PGJ7"/>
    <dbReference type="OMA" id="FWGPPVK"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009988">
        <property type="term" value="P:cell-cell recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001574">
        <property type="term" value="P:ganglioside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000009">
        <property type="entry name" value="alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906:SF6">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB72257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="319" mass="36120" checksum="24156514A4FC1AD5" modified="2019-05-08" version="1">MTPVKPESTLCLAKVILLFNLLQVESYVVATAIFVLTTLLIIYSSSSGNDSLHYKGEFISHAVSRTPINVKKWATKDGYFPVIGNKTMRLHCGQCALITSSSHLLGSEMGSEIDKTECTIRMNDAPTTGYEKDVGSKTTLRVVAHSSVYRVIRKPQEFLNKSQETVCIFWGPPQKMLKNSRGNVYRLIHQAGLAFSSMSAFVIAPKRMQQFDDLFQRATGRDRKKSHSWLSTGWFTMVIAIELCDHVQVYGMAPPNHCRVAPPKHVPYHYYEPKGPDECKTFVGNERAKKGNHHRFITEKDVFAEWAKLYNVSFLHPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHM3</accession>
    <name>A0A401PHM3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0002090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000499">
        <property type="protein sequence ID" value="GCB72611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHM3"/>
    <dbReference type="STRING" id="75743.A0A401PHM3"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="12">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="13">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB72611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="339" mass="39003" checksum="8717DFF1E41AED44" modified="2019-05-08" version="1">MEEASKRKKRSKSEVDEAELLTVPEGWKEEPFTKADNIYGLLEESSFATLFPKYREAYLKECWPLVQSALKEHYITATLDLIEGSMTVSTTKKTFDPYAIIKARDVIKLLARSVPFEQAIRIFQDDVACDIIKIGSLVSNRDRFVKRRLRLLGPKGSTLKALELLTNCYIMVQGNTVSALGPYSGLKEVRKVVFDTLKNIHPIYNIKTLMIKRELAKDAELRTQNWERFLPKFKHKNLNKRKEPRKKRVKKEYTPFPPPQPESKIKEAETAAKRKEERNKAFIPPKEKPVVKVKKAAEVKINVQVLKEKVKTAKKKKLGAPAAEEIAQKIAQKEKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHX3</accession>
    <name>A0A401PHX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0006424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002161">
        <property type="protein sequence ID" value="GCB72689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHX3"/>
    <dbReference type="STRING" id="75743.A0A401PHX3"/>
    <dbReference type="OMA" id="YCRMPDR"/>
    <dbReference type="OrthoDB" id="300500at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042814">
        <property type="entry name" value="Morn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB72689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="17962" checksum="A5083743F01FE54B" modified="2019-05-08" version="1">MAETRYEGGMKDGMFHGQGTLYFPNGSKYVATWDSGAIIEGDYIFADGLEYEEDWTYCDSYDRRFYTEICNGLKPAGRSQLTNLDPPRTIPEGHYDCGDGFYNPVTRVITGYNNKFLRNADDDEHEWIVRTCRKGWDQITGYKPELHQQQLPKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHX8</accession>
    <name>A0A401PHX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Lipoxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0006451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002173">
        <property type="protein sequence ID" value="GCB72740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHX8"/>
    <dbReference type="STRING" id="75743.A0A401PHX8"/>
    <dbReference type="OMA" id="NNGQYDW"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001885">
        <property type="entry name" value="LipOase_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00467">
        <property type="entry name" value="MAMLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="13">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="14">
        <location>
            <begin position="113"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Essential for stabilizing binding to COTL1" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601885-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601885-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601885-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB72740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="70818" checksum="2F2B7BEF588291BB" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIY0</accession>
    <name>A0A401PIY0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0002339</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000581">
        <property type="protein sequence ID" value="GCB73079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIY0"/>
    <dbReference type="STRING" id="75743.A0A401PIY0"/>
    <dbReference type="OMA" id="QHHASWH"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061053">
        <property type="term" value="P:somite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000109">
        <property type="entry name" value="Homeobox protein MOX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB73079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="301" mass="33756" checksum="462BE6427240DC88" modified="2019-05-08" version="1">MDHTIFSCLRSSHAPAQSLHHFSQSPLTLHGRSDHVAFPDLSPSCIITGFPNEENMFTAQRHHHHLHHHHRGHPQQQQQQQQQQAAAQATWHIPQISSPPPLARHTLCIQSESGPPELGSNPSSLVDSNPTLAPNNPNVASCVSGDYGRLAVTPVETEKRHSKRKGDGSETQECSYKGEMNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAVAREKELVNVKKGTLLPSELSGISTSGAHHAGDILSNDESQDSDHSTELGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJU7</accession>
    <name>A0A401PJU7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0006761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002334">
        <property type="protein sequence ID" value="GCB73414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJU7"/>
    <dbReference type="STRING" id="75743.A0A401PJU7"/>
    <dbReference type="OMA" id="WLNSTEW"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000001">
        <property type="entry name" value="Sentrin-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF11">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="394"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB73414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="588" mass="67460" checksum="0FECBFC6104B426F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK29</accession>
    <name>A0A401PK29_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002347">
        <property type="protein sequence ID" value="GCB73461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK29"/>
    <dbReference type="STRING" id="75743.A0A401PK29"/>
    <dbReference type="OMA" id="GEMNIPA"/>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF7">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB73461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="24949" checksum="C989D3A20EC1F6CD" modified="2019-05-08" version="1">MIVLPCSPPSQRDLGVQVHRSLKGATQVEKVVKKAYGMLAFIGRGIEYKNWQLNKQQLQVVKERFQAFLNGETQIVADEAFWNAIQSYYESFLKSDRVARMVHSGGCSANDFRDVFKKNIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDLRSKPARMALSAVSELILSKEQLYEMFQQILGIKKIEHQLLYNACQVSCETRFSLSLRSMALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKM2</accession>
    <name>A0A401PKM2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0002718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000696">
        <property type="protein sequence ID" value="GCB73638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKM2"/>
    <dbReference type="STRING" id="75743.A0A401PKM2"/>
    <dbReference type="OMA" id="FRCHNIG"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF58">
        <property type="entry name" value="CERAMIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="10">
        <location>
            <begin position="70"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB73638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="264" mass="30607" checksum="3477574F95C3E387" modified="2019-05-08" version="1" fragment="single">SCLNAAVAECRDCGLQLSKRTLLENASLTAAEGLLFLICAVGWTVLRKAASRYLFQPLARWCDLPSRDAAKMPESAWKLVFYMASWSYSTYLLFLTDYPFFHDPPSVFYEWRASVDVPQDIAIAYLAQCSFYGHAIYATVYMDAWRKDSVVMLVHHMITLALIAFSYAFRYHNVGILVLFLHDINDILLEFTKLNVYFKNRAGVRHRLNDIVSNIGCCTFAISWFWFRLYWFPLKVLYATCYSSLQSVPNIPFYFFFNILLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKS7</accession>
    <name>A0A401PKS7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calx-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0002817</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRAS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000723">
        <property type="protein sequence ID" value="GCB73736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PKS7"/>
    <dbReference type="OMA" id="WEVAMPA"/>
    <dbReference type="OrthoDB" id="430044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000005">
        <property type="entry name" value="Extracellular matrix protein FRAS1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000003">
        <property type="entry name" value="Fraser extracellular matrix complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000006">
        <property type="entry name" value="Fraser extracellular matrix complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000035">
        <property type="entry name" value="Fraser extracellular matrix complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF1">
        <property type="entry name" value="EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2529"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="106"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="226"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="341"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="460"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="583"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="704"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="825"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="937"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="14">
        <location>
            <begin position="1164"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="14">
        <location>
            <begin position="1289"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="14">
        <location>
            <begin position="1414"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="14">
        <location>
            <begin position="1533"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="14">
        <location>
            <begin position="1655"/>
            <end position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB73736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2633" mass="295587" checksum="A83281414E79AD64" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLQ0</accession>
    <name>A0A401PLQ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Decorin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bone proteoglycan II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0003150</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">May affect the rate of fibrils formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 14">Secreted</location>
            <location evidence="1 12 14">Extracellular space</location>
            <location evidence="1 12 14">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 14">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000841">
        <property type="protein sequence ID" value="GCB74066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLQ0"/>
    <dbReference type="STRING" id="75743.A0A401PLQ0"/>
    <dbReference type="OMA" id="FRCIYER"/>
    <dbReference type="OrthoDB" id="1111193at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016352">
        <property type="entry name" value="SLRP_I_decor/aspor/byglycan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF14">
        <property type="entry name" value="DECORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002490">
        <property type="entry name" value="SLRP_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12 14" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12 14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018809804" description="Decorin" evidence="12 14">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="45"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002490-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB74066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="393" mass="44057" checksum="0D01A0C356AE1F4E" modified="2019-05-08" version="1">MRVIISLAFLVVASWAKPFHQTQLLDFMLEDEGSGFLPESEGPMCPFGCQCHRRVVQCSDLGLTTVPENIPKDTTLLDLQNNKITEIKENDFKNLKNLHALILVNNKIGTVHPKAFVPLVKLQKLYMSKNLLKEIPANMPPSLHELRIHENEITKVKKNVFDNLSQVYALEMGSNPLKNSGIESGAFNGLKKLSFIRLSDAVLTAVPKGLPSTMSEIHLDGNKISHMKADSLKGLHNLARLGLSFNEIIAVDNGTLDHVPYLRELHIDNNALRKVPAGLGDHRYIQVVYLHNNLITAVGVNDFCGLDYYAKKNLYSGISLFNNPVPYWEIQPSTFRCAMNRAVIQLGNFKEGQHGQKIFRGVEEKLFPPEGDRNLEPLPERMVEAGALTMFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLW7</accession>
    <name>A0A401PLW7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0003190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000855">
        <property type="protein sequence ID" value="GCB74103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLW7"/>
    <dbReference type="OMA" id="SENNFWE"/>
    <dbReference type="OrthoDB" id="9943525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027871">
        <property type="entry name" value="DUF4603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611:SF3">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15376">
        <property type="entry name" value="DUF4603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB74103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="991" mass="110020" checksum="1ACC39F4A84AC42E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN11</accession>
    <name>A0A401PN11_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0003583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000991">
        <property type="protein sequence ID" value="GCB74493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN11"/>
    <dbReference type="STRING" id="75743.A0A401PN11"/>
    <dbReference type="OMA" id="HHFLFYT"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000035">
        <property type="entry name" value="28S ribosomal protein S9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB74493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="382" mass="44129" checksum="02642E302A889F8A" modified="2019-05-08" version="1" fragment="single">AACSGRLVGFLRSCCGCAMAMNAPTYGRMSTLMRSICSSSSLHKKSMAATFHAKYTEEFIKQQIEEFNIGKRHLANMMGEDPETINQEDIDRAIQYLFPSGLFDKKARPLMKHPLEVFPKQKAVQWGEDGRPFSYLFYTGKQSYYSLMHDTYEQFLNVQIYEDQLRTKGLFSLDTKPVNLVGSRWLIKEELEEMLVEQISHHDYMHFLQLLERMLSLSYCSIKEEYVLKFRRKMEDQSKKQIIEPLQFDENGIAFSKGEGQRKTAKATVIVRDHGSGKITVNGVDYLMYFSSLQEREQLMIPFQFLDRLGMHDMECTVYSGGPSAQTGAIRLASSRALLSFITEKEMESMRQAGLLTPDPRVRERKKPGQEGARRKFTWKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPH8</accession>
    <name>A0A401PPH8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <shortName evidence="7">HIB-CoA hydrolase</shortName>
            <shortName evidence="7">HIBYL-CoA-H</shortName>
            <ecNumber evidence="7">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0018940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="7"/>
    <dbReference type="EMBL" id="BFAA01013645">
        <property type="protein sequence ID" value="GCB75008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPH8"/>
    <dbReference type="STRING" id="75743.A0A401PPH8"/>
    <dbReference type="OMA" id="CWEKESS"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB75008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="144" mass="16029" checksum="B81D89FEE2A706F5" modified="2019-05-08" version="1" fragment="single">VRALSRLQIVQKHLMSTNANLEKEVHLVKSGCAGIIILNRPKTLNSLNLSMIRQIYPKLKEWEQDNETSLVLIKGAGEKAFCAGGDIRAVTEAGKVGDRLAEDFFREEYILNNAIGNCRIPYVALIDGITMGGIPKYTEVITWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPL9</accession>
    <name>A0A401PPL9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 255A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein FAM70A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0018950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM255 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013666">
        <property type="protein sequence ID" value="GCB75073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPL9"/>
    <dbReference type="OMA" id="TEVCKAG"/>
    <dbReference type="OrthoDB" id="10034004at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028014">
        <property type="entry name" value="TMEM255"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33721:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 255A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33721">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 255B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14967">
        <property type="entry name" value="FAM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB75073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="117" mass="12279" checksum="D12660BDB78B54C1" modified="2019-05-08" version="1" fragment="single">MQRPLTQQVTGLTLHDSVGLFNKRKKASVLVSGALLIASVLILTVGLAATTRTLNVSVGGYYPGVILGFGSFLGLIGANLLENKRQMLVASIVFISFGVLASFCCAIVDGVFAARHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPT8</accession>
    <name>A0A401PPT8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017556">
        <property type="protein sequence ID" value="GCB75137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPT8"/>
    <dbReference type="OMA" id="ELICYNY"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158791">
        <property type="entry name" value="MgtE N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="167" mass="18733" checksum="ACFDCA98ADD8D0B8" modified="2019-05-08" version="1">MRRSHLQKKKERENRFSKQPEEEKTAEIIAEITEITEEITAEITEEITAEITEEITVEITEGITEEITEEIRAEIRAEIRAEISAEISAEISAEISAEISAEISAEISAEIAAEIAAEIAAEIAAEIAAEITEEITEEITEEITADITEAITEEITEEVFHQYKWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR18</accession>
    <name>A0A401PR18_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium/glucose cotransporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0017358</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011212">
        <property type="protein sequence ID" value="GCB75562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR18"/>
    <dbReference type="STRING" id="75743.A0A401PR18"/>
    <dbReference type="OMA" id="CQKYCGS"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000051">
        <property type="entry name" value="Low affinity sodium-glucose cotransporter-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF151">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB75562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52567" checksum="A5DB8FD229B61592" modified="2019-05-08" version="1" fragment="single">GLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAMREKYMNAITSQTTDPTLNISASCYTPREDSFHLFRNPISGDIPWPGLVFGLTILAIWYWCTDQVIVQRCLSAKNMSHVKAGCVLCGYLKLLPMYLMVFPGMISRILYTDVVACVVPSICKEYCDAEVGCTNIAYPRLVVKLMPMGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIWTKIRPKATEKELMLAGRVFTLVLIGISIAWIPIVQTAQSGQLFDYIQSITSYLGPPIASVFLLAIFVKRVNENGAFWGLIFGLAVGLSRMIPEFVFGTGSCVSPSNCPVVICGIHYLYFAIILFVVTCLMVLIVSFLTKPIDDIHLYRLCWSLRNNTEERIDLDNDNWKNEDNDSKMDMDEASETPQNVSCWKTAYNWFCGFEQQAKKLSKEEQEALQQKLTDISEKPLWRNVVNINAVILLTVCIFFWAYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTN4</accession>
    <name>A0A401PTN4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0020481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016590">
        <property type="protein sequence ID" value="GCB76506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTN4"/>
    <dbReference type="STRING" id="75743.A0A401PTN4"/>
    <dbReference type="OMA" id="MFHANMD"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="5 6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB76506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="251" mass="27299" checksum="6216EDC040FD7377" modified="2019-05-08" version="1">MESSSEQAESLKGEYTTENYQQNLDTQVAFTHNINIPKQISDCPHATLLENIISRLNILEREVSILRQQCSGNCLGESSASGRIDYAPMCNGHGNFSMETCDCSCEFGWTGKGCLVQCCPSNCSGHGQCVDGECLCDRGYTGQDCSELRCPRDCSGHGLCVDGQCVCEEPYKSEDCGQLKCPRECSGHGQCINDSCLCYETYTGEDCHQMRCLNDCSNKGLCNHGVCSCQDGYTGEDCGEGKASYCVVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUA2</accession>
    <name>A0A401PUA2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal-induced proliferation-associated 1-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008851">
        <property type="protein sequence ID" value="GCB76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUA2"/>
    <dbReference type="STRING" id="75743.A0A401PUA2"/>
    <dbReference type="OrthoDB" id="9335786at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12930" checksum="1E513BF2BE648209" modified="2019-05-08" version="1" fragment="single">QRASLFGVDDSDHRPDSLLLDGSIQADRHPSPLAVHRREESPTTLSGKVTELEMLLNELRDDLRRAKEDRAALQEEVQHLREDNLRLQEESHTASAQLKKFTEWVFNTIDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUF8</accession>
    <name>A0A401PUF8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 13">Adenylosuccinate lyase</fullName>
            <shortName evidence="13">ASL</shortName>
            <ecNumber evidence="7 13">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0017501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="7 13"/>
    <dbReference type="EMBL" id="BFAA01011435">
        <property type="protein sequence ID" value="GCB76745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUF8"/>
    <dbReference type="STRING" id="75743.A0A401PUF8"/>
    <dbReference type="OMA" id="NTPNIGW"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="14">
        <location>
            <begin position="382"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB76745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="489" mass="55761" checksum="4272F73F73CE93FC" modified="2019-05-08" version="1">MAAGPERGDGGDWELRRYRSPLVSRYSSPEMAFNFSELKKFNTWRRLWLYLARAEKELGLPITQEQLQEMESNLENIDFKMAAEEERKLRHDVMAHIHTFAHCCPNAAAIIHLGATSCYVGDNTDLIVLRDGFDILLPKLARVISRLADFSQKHADLPTLGFTHYQPAQLTTVGKRCCLWLQDLCMDLRNLERARNELRFRGVKGTTGTQASFLQLFEGDHSKVEELDRLVTEMAGFKQTYLVTGQTYSRKVDIDSLAVLSSLGATVHKLCTDIRLLANLKEMEEPFEKDQIGSSAMPYKRNPMRSERCCSLARHLMVLLLDPLQTASVQWFERTLDDSANRRICLAESFLTADIILSTLQNITEGLVIYPKVIERHIRHELPFMATENIIMAMVKAGENRQDCHERIRVLSQQAAAVVKHEGGDNDLISRIRDDAYFSPIHGQLEALLNPTSFVGCAPRQVTRFLEQEVRPLLVHYASQMELKVELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV78</accession>
    <name>A0A401PV78_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0018416</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01012805">
        <property type="protein sequence ID" value="GCB77036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV78"/>
    <dbReference type="STRING" id="75743.A0A401PV78"/>
    <dbReference type="OMA" id="TSHYPIN"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000002">
        <property type="entry name" value="Probable histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF51">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="16">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB77036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="325" mass="35290" checksum="EA746E0D2BDA1AB3" modified="2019-05-08" version="1" fragment="single">NLFPTLGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFKQPIVDTFDIRILMAKSVKYTVNFLEAKENDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSQMTVWLSTAPTEPLTHWYQVRCLLQSPLFTKAGDTLSGTAVLNANKRQSYDISILAQVDQTGSKSSNVLDLKNPFFRYTGTTPSPPPGSHYVSPSETMWNTSASYNLSSGLAVSGVPTAYDLSSVIASGSGVSHNNLIPLANTGIVNHTHSRLGSIMSTGFIQGSSSGGQGGVIASTSHYPINSQFTMGGAAISMASPMSISTNTMHYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW53</accession>
    <name>A0A401PW53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0016672</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010249">
        <property type="protein sequence ID" value="GCB77367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW53"/>
    <dbReference type="STRING" id="75743.A0A401PW53"/>
    <dbReference type="OMA" id="MTIFVMD"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="17">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB77367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="504" mass="55879" checksum="6030C05EE307971A" modified="2019-05-08" version="1">MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKAAIDLEEMASGLNKRRMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCTKLAYYFQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIAAEGVEKFKKENFEIIIVDTSGRHKQEDSLFEEMLQVSNAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEELIDKLKHGQFTLRDMYEQFQNIMKMGPFSQIMGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDNKDGAKLFSKQPGRIQRVARGAGVTTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVNPSQMAKLNQQMAKMMDPRVLHHMGGMAGLQTMMRQFQQGATGNMKGMMGFNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWI7</accession>
    <name>A0A401PWI7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014196">
        <property type="protein sequence ID" value="GCB77497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWI7"/>
    <dbReference type="STRING" id="75743.A0A401PWI7"/>
    <dbReference type="OMA" id="ITMELHN"/>
    <dbReference type="OrthoDB" id="2316821at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052089">
        <property type="entry name" value="Ankyrin-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46071">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46071:SF3">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="217"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="410" mass="46126" checksum="2B704D5280F1A835" modified="2019-05-08" version="1">MLLEKGADPLAGSIGKSGISASLQGIINPFSQAAAHGHRNVLQKLLSQPDTLNSDIMSLEDILAEGAEDSKQQLPKAGLTRSSKARRKALQDALYQSAEHNYLDITMELHNLGVPWTLYSWLKSLETSLIQHRWSIALNLLKEFDAVKDVYSQDMITWGLTLMFDIFRLSKNDAVLRQLAAIFSYCYGPYPIPAIQESDKKIKATVEPIRLNNREQSDIIFLVEGKPFYGHRAQLSAASPRFKKLIAFCPAADVETCSPIQINDIKYSTFQCLVQYIYDGGTERLDISKSQALEVLSASSVFKLNLLTRHCETICARNLTLADSIHTYQHAKVLKANELVSYCNGYFLKNMLPLLEQDSFQQMVQSQTENYQDLLTDLQQALASRMQAVHRPVAKETTIINYLDLFLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYZ2</accession>
    <name>A0A401PYZ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0019395</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01014393">
        <property type="protein sequence ID" value="GCB78351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYZ2"/>
    <dbReference type="STRING" id="75743.A0A401PYZ2"/>
    <dbReference type="OMA" id="WTHICRE"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000035">
        <property type="entry name" value="PHD transcription factor Rum1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000001">
        <property type="entry name" value="Putative lysine-specific demethylase 5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF3">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="16">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="15">
        <location>
            <begin position="78"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB78351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="178" mass="20545" checksum="76A29A1B2D1B02C2" modified="2019-05-08" version="1">MNPAVEFIPPPECPVFEPTPEEFADPFSFINKIRRIAERTGICKVRPPQAWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKFWELQGSTLKIPHVERKILDLFLLNKLVAEEGGFELVCKERRWSKIAHMMAYPPGKALGSLLRSHYERILYPYNLFQSGASLLVSVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q067</accession>
    <name>A0A401Q067_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013188">
        <property type="protein sequence ID" value="GCB78771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q067"/>
    <dbReference type="OrthoDB" id="9836301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043444">
        <property type="entry name" value="TESPA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469:SF14">
        <property type="entry name" value="PROTEIN ITPRID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469">
        <property type="entry name" value="SPERM SPECIFIC ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="10820" checksum="8B68B8CA16AE146D" modified="2019-05-08" version="1" fragment="single">DYNQQSVQEWLNTSCTLHANEHRPQSPQRTGILKRMYSIEDDLMLGIEANLYPSGMQNMSVQDYMRTLHTCSEKQTLSRWNSVASATSVASGPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0X4</accession>
    <name>A0A401Q0X4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017215">
        <property type="protein sequence ID" value="GCB79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0X4"/>
    <dbReference type="OMA" id="HIACLLM"/>
    <dbReference type="OrthoDB" id="9947971at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="17275" checksum="3E3CF1BE32EC4807" modified="2019-05-08" version="1">MIAFLHKNMFAALDIECSLDFSGISCRRNNTTQKILIGVGVALSVVVVVGVLSCCCCGCCRSSQQQPTVVTAVTCAQQMPVYPPGRGYQPVPLQLSPAQLAMPTAPYSNHYPAAYPNYCQPPTYQEAASMGQPQYYPATQPYYNLGANTVDNPAFVDPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1Q0</accession>
    <name>A0A401Q1Q0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Dynein heavy chain region D6 P-loop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0020775</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017291">
        <property type="protein sequence ID" value="GCB79359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1Q0"/>
    <dbReference type="STRING" id="75743.A0A401Q1Q0"/>
    <dbReference type="OMA" id="RQMDNPC"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="15">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="16">
        <location>
            <begin position="236"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="14">
        <location>
            <begin position="659"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="17">
        <location>
            <begin position="804"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB79359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="96872" checksum="8E0F8112FD455E43" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3R8</accession>
    <name>A0A401Q3R8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein FAM161A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0017047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAM161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010772">
        <property type="protein sequence ID" value="GCB79953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3R8"/>
    <dbReference type="STRING" id="75743.A0A401Q3R8"/>
    <dbReference type="OMA" id="RENRWPY"/>
    <dbReference type="OrthoDB" id="2150121at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051655">
        <property type="entry name" value="FAM161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019579">
        <property type="entry name" value="FAM161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501:SF3">
        <property type="entry name" value="PROTEIN FAM161A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10595">
        <property type="entry name" value="FAM161A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="596"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="618"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB79953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="655" mass="76643" checksum="E394254E7B6F60B0" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q469</accession>
    <name>A0A401Q469_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="29">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">scyTo_0017098</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 29">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Golgi apparatus</location>
            <location evidence="28">trans-Golgi network membrane</location>
            <topology evidence="28">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Membrane</location>
            <topology evidence="29">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Presynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Synapse</location>
            <location evidence="26">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 29">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="29"/>
    <dbReference type="EMBL" id="BFAA01010827">
        <property type="protein sequence ID" value="GCB80176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q469"/>
    <dbReference type="STRING" id="75743.A0A401Q469"/>
    <dbReference type="OMA" id="ATERCIF"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="25" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 29" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="24" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="21 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0770">Synapse</keyword>
    <keyword evidence="11" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="12 29" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="30">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00037864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="GCB80176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="347" mass="40293" checksum="9E8829026802BA18" modified="2019-05-08" version="1">MTLNWINYFSSSAQKFIGVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLGLNIVPRTKVVYLASETFNYSAIDRVKSRGKKLALEKVPKVGQRFHRIGLPPKVGSFQLFVDGYKDADFWLRRFEAEPLPNKTNRQLQLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDSASSKDADWVVVKEPVIKIAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLVLPKISDPNFVKDLEEDLYELFKKDPGFDRGQFYKQISVMRGQILNLTQALKDGKSPLMLIQIPPVIVETTRSHHRSSDLYTQSFQSRKPFFTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4I4</accession>
    <name>A0A401Q4I4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010873">
        <property type="protein sequence ID" value="GCB80280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4I4"/>
    <dbReference type="STRING" id="75743.A0A401Q4I4"/>
    <dbReference type="OMA" id="TFIDKCM"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="12">
        <location>
            <begin position="382"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB80280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="741" mass="83773" checksum="CF4077595A74F98A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5L6</accession>
    <name>A0A401Q5L6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009793">
        <property type="protein sequence ID" value="GCB80674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5L6"/>
    <dbReference type="STRING" id="75743.A0A401Q5L6"/>
    <dbReference type="OMA" id="RMAKCTT"/>
    <dbReference type="OrthoDB" id="10053061at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF81">
        <property type="entry name" value="PROTEIN RETINAL DEGENERATION B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="643" mass="71754" checksum="2B91D5D9B65ABA0E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q619</accession>
    <name>A0A401Q619_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026242">
        <property type="protein sequence ID" value="GCB80787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q619"/>
    <dbReference type="STRING" id="75743.A0A401Q619"/>
    <dbReference type="OMA" id="ELYNTIM"/>
    <dbReference type="OrthoDB" id="9950513at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042888">
        <property type="entry name" value="GPSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47617">
        <property type="entry name" value="G-PROTEIN SIGNALING MODULATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47617:SF1">
        <property type="entry name" value="G-PROTEIN-SIGNALING MODULATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="297" mass="31589" checksum="5475E95E98ACCE6C" modified="2019-05-08" version="1" fragment="single">TKRLTPDFSDREVFLDLVWEVQSRRLNDQRCSFRKKVKDRRAYRSMPSTPLDKEKPFFPSMSSLQTEEFFDLIAYSQSRRLNDQRADFEDSPTVELSSPFPEDIVEYLAPVGRAASQTQRGEAPAAIPAERNQNPAEEEEIPAEGAEGPAEGAKSPAEGAGGPAEGAEGPTEGAKSPAEGAGGPAEGAGSPAEGAGCPAEGAERPEEVDASPAEEAGSPSRGTERPADGAESPAGEAENPSGGADSPGEKGEAPAEEENNPAEREELPAEKVKKEPEDELYNTIMTHQVQGNKRVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7P4</accession>
    <name>A0A401Q7P4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-hydroxytryptamine receptor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serotonin receptor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0021391</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018882">
        <property type="protein sequence ID" value="GCB81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7P4"/>
    <dbReference type="STRING" id="75743.A0A401Q7P4"/>
    <dbReference type="OMA" id="WMPFFTV"/>
    <dbReference type="OrthoDB" id="5959645at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032098">
        <property type="term" value="P:regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15055">
        <property type="entry name" value="7tmA_TAARs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000030">
        <property type="entry name" value="trace amine-associated receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001520">
        <property type="entry name" value="5HT4_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01059">
        <property type="entry name" value="5HT4RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="49"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB81415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="357" mass="39625" checksum="600F20514659EADE" modified="2019-05-08" version="1">MENISSSFNVTSPPGWRTAGQCLSSTGTSAVKPGLYIFITVIMIATMVGNCLVVLAIFYFKKLRSITNAFVLSLAVADFLVGIMVMPYSMIRTIEGCWHFGPIFCQIHSSLDVMFCTASILHLSCIALDRYYAVCDPLAYHCKMSPGKVVILLFVCWTVPAAISFIPIMLQLHKFSVAPDLSTKSSCVFRVNPIYAVCASVIAFYLPMFIMLAAYWKIYRAARKQAIQIGAVDNQIQGCASGFVTAHTHKQSIKRERKAAKTLGIIIGAFLVFWLPFFTANIVDPFLGYKLGRVTWEVLIWLGYSNSSLNPFLYAFFNRSFRRAFLTIISCKICAPRSLQNIDLSNSKPGAAQESVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q800</accession>
    <name>A0A401Q800_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022853">
        <property type="protein sequence ID" value="GCB81496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q800"/>
    <dbReference type="STRING" id="75743.A0A401Q800"/>
    <dbReference type="OMA" id="NASIMIF"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="191" mass="20963" checksum="7FD31699FBF01028" modified="2019-05-08" version="1" fragment="single">VQNGVALIRPPGHHAERDVACGFCFFNNVALAARFAQNLVGHKIKVLILDWDVHHGNGTQHMFEDDPSVLYISIHRYDNGSFFPNTEDADYTKVGIDAGEGFNVNIPWNGSKMGDAEYMTAFHRLVMPISYQFQPDLVLVSAGFDAAQGDPLGGCKVSPECYAHLTHMLLGLAGGRVVMALEVREASLYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q957</accession>
    <name>A0A401Q957_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021802">
        <property type="protein sequence ID" value="GCB81919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q957"/>
    <dbReference type="STRING" id="75743.A0A401Q957"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF15">
        <property type="entry name" value="RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="255" mass="29463" checksum="1FE80ECED1F506F0" modified="2019-05-08" version="1" fragment="single">QPIIGNLLYYRYMNPAIVAPDAFDIIDISAGGGGLTTDQRRNLGSIAKVLQHAASSKLFDKENCHLGSVNDYLSQAHMKFREATPDGALFSQDTDHQRAMQRRTIRDAKTPEKMKRDQVQSEENQMSLKEKKERIEQSLKKLATLGKVNPQNKYQDLINDVAKDIRNQRRYRQRRKAELVRLQQTYSGLISKTAFFEEQIDYYNQYIKTCMDNLASKGKFKNVIFDICPTEEVGDFEVKAKFMGVQMDSFMLHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9A2</accession>
    <name>A0A401Q9A2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019188">
        <property type="protein sequence ID" value="GCB81958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9A2"/>
    <dbReference type="OrthoDB" id="10423823at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10503" checksum="6DEB27FF54EEE7EA" modified="2019-05-08" version="1" fragment="single">WNDIRRGSNQQTHKGTYSAIATSKTGPNKGIYDSVQLYCNMQQPNSVRTPGHEYTNVLDLAACEFIYYDLTKERIILPMNNIHFSHQIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAY0</accession>
    <name>A0A401QAY0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022206">
        <property type="protein sequence ID" value="GCB82539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAY0"/>
    <dbReference type="STRING" id="75743.A0A401QAY0"/>
    <dbReference type="OrthoDB" id="64868at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF64">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="113" mass="13045" checksum="7D86042544EB26E3" modified="2019-05-08" version="1" fragment="single">HLQKGINTWKSMQFKEWVLSHPGQVVLTVSQIMFNRDCETCFSGSKPQSQLQDVHLVLMSRLDVLADLMSTPLRAFQETVLETLLTIIVHCRDILSELIDKNISKADDFEWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB83</accession>
    <name>A0A401QB83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0022380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022323">
        <property type="protein sequence ID" value="GCB82643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB83"/>
    <dbReference type="STRING" id="75743.A0A401QB83"/>
    <dbReference type="OMA" id="ELADFEC"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_RZ"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="8">
        <location>
            <begin position="696"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB82643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="796" mass="89733" checksum="23886FFB8B82431E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBH6</accession>
    <name>A0A401QBH6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022353">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="9819" checksum="D4FF502B3DA5A560" modified="2019-05-08" version="1">MEHPEEPPEEHPEEHPEEHPEEHPEEHPEEHSEEHPEELPEENPDDPMEYPEEFPEEIPEEQPEEQPEEQPEEHPEECPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDB6</accession>
    <name>A0A401QDB6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029576">
        <property type="protein sequence ID" value="GCB83371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401QDB6"/>
    <dbReference type="OMA" id="PNCRILG"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="93" mass="10886" checksum="1C75F3F8FFE4EDAA" modified="2019-05-08" version="1" fragment="single">ELVEYYQTHSLKESFKQLDTALRFPYKQRDRTIQRSNSRNAVFNPRPIGMATARYNFAARDMRELTLREGDVVKIYSKIGGDQGWWKGEAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFC3</accession>
    <name>A0A401QFC3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01058330">
        <property type="protein sequence ID" value="GCB84085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFC3"/>
    <dbReference type="STRING" id="75743.A0A401QFC3"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="8115" checksum="33A36DB70EECBE61" modified="2019-05-08" version="1" fragment="single">MFTPNCFILLKQKREKKEALLLFYNRTAEAKVRSIIEYVSDLLESGRDKFLVFGHHRLVLDALCATLGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG12</accession>
    <name>A0A401QG12_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01059267">
        <property type="protein sequence ID" value="GCB84325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG12"/>
    <dbReference type="STRING" id="75743.A0A401QG12"/>
    <dbReference type="OMA" id="ANFTNAR"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="508" mass="50518" checksum="F9DF2C748E493302" modified="2019-05-08" version="1" fragment="single">GVTLTLTSVILTGVTLTLTSVILTGVTLTLTGVTLTSVILTGVTLTGVTLTLTSVTLTSVILTGVTLTLTGVILTGVTLTSVTLTIVILTGVILTGVTLTLTGVILTGVTLTLTSVILTSVTLTLTSVILTGVTLTGVTLTLTSITLTGVTLTGVTLPLTSVILTGVILTSVTLTLTSVILTGVTLTSVILTGVTLTGVTLTLTSVTLTGVILTSVTLTLTGGILTGVTLTSVTPTIIILTGVTLTLTGVILTGVTLTSVILTGVTLTLTSVILTGVTLTSIILTCVTLTGVTLSLTSVILTGVTLSLTSVILTGVTLTGVTLTLTSVILTGVTLSLTSVILTGVTLSLTSVILTGVTLTGVTLTGVTLTGVTLTLTSVTLTGVTLTSIILTGVTLTDVTLTSIILTSVTLTGVTLPLTSVILTGDTLTGVTLTLTGVTLTGVTLTGVTLTSVTLTGVTLILTGVKLTSVTLTPGMLTSVTLILTSVKLTSVTLTHVTLTRVTQPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG81</accession>
    <name>A0A401QG81_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0025148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01073636">
        <property type="protein sequence ID" value="GCB84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG81"/>
    <dbReference type="STRING" id="75743.A0A401QG81"/>
    <dbReference type="OMA" id="SECEVVR"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="26423" checksum="1E0414EA5BA340CC" modified="2019-05-08" version="1">MFEKYGEVSECEVVRNYAFVHMEKLSQATRAIKALHRSNVHGAHVTVGVANARTRNTTKVFVGNLAEPVSGAAVKELFQRFGRVVDLDVARTFAFVYMEQERQALAAIQALDGTTLQGQNMFVQLSRSNPSQETWGAGQEGGGRGMAYGQEGGGRGMAYHPHYRPGPPHFAAYYDQPPAYDAYRPMPRGRPFGGQPPAYMMEQQHRRPAPPGMMRPGPQQYLRAPPFVNGYGSRLRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGD5</accession>
    <name>A0A401QGD5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01074251">
        <property type="protein sequence ID" value="GCB84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGD5"/>
    <dbReference type="STRING" id="75743.A0A401QGD5"/>
    <dbReference type="OrthoDB" id="10048737at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="46" mass="5354" checksum="6631E1718FEF5EBE" modified="2019-05-08" version="1" fragment="single">MDEEESNMSTATRVFKAMYSAFQDDMDLKADLRSDTLDTREDCELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH12</accession>
    <name>A0A401QH12_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="64" mass="8027" checksum="9308743B2CFAA671" modified="2019-05-08" version="1" fragment="single">MEKENKKIRDKARKERNEVVRQLVAFIRKRDRRVQAHRKRLEEQNAEKVKRFEELRKQQKLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIF0</accession>
    <name>A0A401QIF0_SCYTO</name>
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        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
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                <person name="Tatsumi K"/>
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                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
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                <person name="Tanegashima C"/>
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                <person name="Murakumo K"/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="32534" checksum="0983C5BE1E171FD8" modified="2019-05-08" version="1" fragment="single">SNRERHTQRETERDRDRDRERQRERQSQRETQRDRETEREREGETERETERETESERDRERQRETERQRETERDRERERQRERQSQRDRERERQRERHTERDRERQRERQRERDTERHRETERKTDTERDIETERDRERERERDRQRDRERQRETHIDRDIETERERERQSETQRDRDRERDRERDRERHRERESEREPETERETERETETERDTERQRDREGARLGERDRVREQQRETHTERDRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401QIT5_SCYTO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
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                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="144" mass="14569" checksum="5F29D3176925318F" modified="2019-05-08" version="1">MSSEEDVGNVSDEEDIGNVSDEEDVGGVSGEEGFGNVSGEEDIENVSGEEDVGNVSDHEDVGNVSDEEDVGGVSIEEGFGNVSGEEDVGNVSGEEDVGNVSGEEDVCNVSGEEDVGDVSGEEDVGSASCEEDVGNLSGEDDLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKV7</accession>
    <name>A0A401QKV7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Onimaru K"/>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
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                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
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            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="141"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="55"/>
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    </feature>
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        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="141" mass="17125" checksum="974CD2596C874AB8" modified="2019-05-08" version="1">MEGRKEGRKKGRKEEGKEGRKEGRKEGRKDGRKDGRKKGRKKGRKKGRKKGRKKERKEERKEERKEERKEEREEERKGERKEGKKEGKKEGKKEGKKKERKKEKRKGRRKERKKESRKESRKAGKKERKEESCFLNLSSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM60</accession>
    <name>A0A401QM60_SCYTO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01304036">
        <property type="protein sequence ID" value="GCB86511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM60"/>
    <dbReference type="STRING" id="75743.A0A401QM60"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="278" mass="28755" checksum="DC0883AAF2B571DC" modified="2019-05-08" version="1" fragment="single">SSRNVNVLNGTSGIKSRNEQNAPSGEVLKDGNDPEVTNEEIDSNVSNDNDASGKIARNGDELNAASGEISRAGNELNAASGEISRAGNELNSRNANVLNGTSGIKSRNEQNAPSGEVPKDGNDPELTNEEIYTNVSKENDTSGTIARNGNELNAASGEISRAGNELNAARGEISRAWNKLNAASGEMSRAGNEQNPNSGEIPRAGNKLNAASGEISRTGNKLNSASGEISRAGNKLNAARGEISRAGNELNAAKGEIFRAGNELNAASGEISRAGNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM68</accession>
    <name>A0A401QM68_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0027185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01298190">
        <property type="protein sequence ID" value="GCB86470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM68"/>
    <dbReference type="STRING" id="75743.A0A401QM68"/>
    <dbReference type="OMA" id="CYEEKIR"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF231">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="2">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="VLIG-type G" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB86470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="63" mass="6842" checksum="8840E115E9568C2A" modified="2019-05-08" version="1" fragment="single">MDTRFYDCYEEKIRPCIDLIDSLRRLGVDKDLALPAIAVIGDQSSGKSSVLEALSGVSLPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMU7</accession>
    <name>A0A401QMU7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01341219">
        <property type="protein sequence ID" value="GCB86737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMU7"/>
    <dbReference type="STRING" id="75743.A0A401QMU7"/>
    <dbReference type="OrthoDB" id="418358at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="63" mass="7429" checksum="D7424C3761FC23C1" modified="2019-05-08" version="1" fragment="single">LIEDLRKELEYLQIFQLDSERAVWSRNPASNAIEISFRSKEMELEYEAKRLKQVNQAGLCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHC4</accession>
    <name>A0A401NHC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Neutral ceramidase</fullName>
            <ecNumber evidence="2 7">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0014138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="2 7"/>
    <dbReference type="EMBL" id="BFAA01007478">
        <property type="protein sequence ID" value="GCB60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHC4"/>
    <dbReference type="STRING" id="75743.A0A401NHC4"/>
    <dbReference type="OMA" id="EYTTMAG"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000001">
        <property type="entry name" value="N-acylsphingosine amidohydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="9">
        <location>
            <begin position="470"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="629" mass="69398" checksum="918B55DCEAD44EEF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJC6</accession>
    <name>A0A401NJC6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0014265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007590">
        <property type="protein sequence ID" value="GCB61001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJC6"/>
    <dbReference type="STRING" id="75743.A0A401NJC6"/>
    <dbReference type="OMA" id="ALNIMPP"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000002">
        <property type="entry name" value="transcription factor 7-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013558">
        <property type="entry name" value="CTNNB1-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08347">
        <property type="entry name" value="CTNNB1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="313"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="10">
        <location>
            <begin position="313"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB61001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="535" mass="58719" checksum="072261D232CB5A99" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJE5</accession>
    <name>A0A401NJE5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HELP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0014269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007593">
        <property type="protein sequence ID" value="GCB61021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJE5"/>
    <dbReference type="STRING" id="75743.A0A401NJE5"/>
    <dbReference type="OMA" id="SSKXGHM"/>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000040">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000044">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000024">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="5">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="6">
        <location>
            <begin position="185"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="5">
        <location>
            <begin position="577"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="756"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB61021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="91204" checksum="BD5ABF621A5B475B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJR5</accession>
    <name>A0A401NJR5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Upstream-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0004049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the grh/CP2 family. CP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001161">
        <property type="protein sequence ID" value="GCB61103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJR5"/>
    <dbReference type="STRING" id="75743.A0A401NJR5"/>
    <dbReference type="OMA" id="SXSVRPR"/>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09537">
        <property type="entry name" value="SAM_CP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000036">
        <property type="entry name" value="upstream-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF13">
        <property type="entry name" value="UPSTREAM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="11">
        <location>
            <begin position="60"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB61103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="503" mass="56839" checksum="6C9FDA3C76D68393" modified="2019-05-08" version="1">MAWVLKMDEAIESGLVHDFDSSLSGIGQELGSGAYSMSDVLALPIFKQEDSNLPSENETKHPPFQYVLYSATSPAVKLHDETLTYLNQGQSYEVRMLDNRKIGDLPEISGKMVKSIVRVVFHDRRLQYSEHQQLEGWKWNRPGDRLLDLDVPMSVGIIDPRTNPAQLNTIEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQIDTFKENETGEYTDHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAQEKEKYQPSYETTILTECSPWPDNAYVNSSPSTTPTFTSGQVSTYSVPDSNSSSPNHQDEGTTQFVVEQLCPTATIQEAQQWLHKNRFSTYARLFSNFSGSDLLKLTRDDLVQICGSADGIRLFNALKARSVRPRLTIYVCQESQHARGISQLASLQDNENGEGDSRAIYVYHAIYLEELTTAELAKKIATIFNISPNQINQVYRQGPTGIHVLVSDQMVHNFQDESCFVISTVKAENTEGYHVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NK81</accession>
    <name>A0A401NK81_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SOWAHA-C winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0004071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SOWAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001173">
        <property type="protein sequence ID" value="GCB61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NK81"/>
    <dbReference type="OMA" id="WECLQNG"/>
    <dbReference type="OrthoDB" id="60433at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058889">
        <property type="entry name" value="WHD_SOWAHA-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25877">
        <property type="entry name" value="WHD_SOWAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SOWAHA-C winged helix-turn-helix" evidence="6">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB61286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="704" mass="78570" checksum="3FB446DC3DDF12AA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLS8</accession>
    <name>A0A401NLS8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007711">
        <property type="protein sequence ID" value="GCB61851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLS8"/>
    <dbReference type="OMA" id="SVWCMIC"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF34">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019452595" description="ZP domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28777" checksum="D0D90D96B9D222A3" modified="2019-05-08" version="1" fragment="single">GEEFLSEMPSVGTHGWMCLLMILCPAASASQKTECIKLNPCKCIMEDGSGVINLAAMGDADGFLERGKPLTASGGESDPEILYSFSPCLPFSEPVEFAFECLNVAVCLVTRHQPQSGETVDFLNFGMHEDNEFSYDNISQTLTVIYPASHSSPLRTVVRFNCSSSYSVVVSRDAANPSLFQISVDSPCACPNGCKPQDVGPGTIISVVFSVTVTAYFLIGLCALNPVRTPNGIEIIPKEHIWCSLCYACVERKGRKRRKYLQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM88</accession>
    <name>A0A401NM88_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005168">
        <property type="protein sequence ID" value="GCB62005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM88"/>
    <dbReference type="STRING" id="75743.A0A401NM88"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="110"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="374" mass="40858" checksum="1893A03601915415" modified="2019-05-08" version="1">MLALHDSYIMCEVGSSRWDLGCELESSRWVSWVCGLVFTIGTSALMLALHDGNLIVSLAFHDGNLGVRLYLHDVLMLALHDGYIRCEIGPSYHSRKEDGTVSSLVLQCVQVETIGDAYMVVAGVPEKTKYHAHNICDMALDMVRSIGHLKDPSTGSNIQIRVGVHSGMVVAGVVGHKMPRFGLYGDTVHSASAMESNGKEMHIQLSGSTYEHLIDSPFIFERRGTITIKGNVEIETYWLTGKRDKDANAQAACPQYENQAISTTTLSPLSSVGGKGELMNPIKMRDDEATVELLPREMVISTGSLGKSMKGISTNEDSFCQGHYKESFLENAPEEMTQQQECAQCDATLEPCGDSFSASQNGAMSIKTQLCHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNC3</accession>
    <name>A0A401NNC3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Torsin-1A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0007229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002573">
        <property type="protein sequence ID" value="GCB62391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNC3"/>
    <dbReference type="STRING" id="75743.A0A401NNC3"/>
    <dbReference type="OMA" id="FYCNIWE"/>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002370">
        <property type="entry name" value="Torsin family 3, member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017378">
        <property type="entry name" value="Torsin_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF3">
        <property type="entry name" value="TORSIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038079">
        <property type="entry name" value="Torsin_2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019006687" description="Torsin-1A C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="8">
        <location>
            <begin position="305"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038079-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="364" mass="41626" checksum="4E02E8B86E406E1B" modified="2019-05-08" version="1">MNFQWLPLLCWWLQAVKGNLFQEQLGTFSEIFHSLPGQFWNSECESKELTDISKQNANTLEAWSFFIHEIEGWYCSVQECCESGDCRLTNNITGLEHDLSKKLHGQHLAKEVVVKAVKGFSATKSPEKALALSFHGWSGTGKNFVAKIIADNLYRDGLRSECVHFYIAPFHFPHANMVDIYKGQLQQFILTAVQQCKQSLFIFDEAEKLHPGLIDAIKPYIDHYDHVDGVDFRKSMFIFLSNVGGNSINSLTLEFWRAGQNREEITMDDLEHQIQREVATSRGGFARSGLVTENLIDFFIPFLPLEYKHVKLCVRDALRSRGIKYDLDILDEVAKGLLYVPKEEKLFAAKGCKSVSQRVNFFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNQ2</accession>
    <name>A0A401NNQ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Basigin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0000035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Basolateral cell membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000005">
        <property type="protein sequence ID" value="GCB62474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNQ2"/>
    <dbReference type="OMA" id="TITGHKW"/>
    <dbReference type="OrthoDB" id="5970915at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000291">
        <property type="entry name" value="Neuroplastin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF107">
        <property type="entry name" value="BASIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01856">
        <property type="entry name" value="BASIGIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB62474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="358" mass="39884" checksum="69D9A24A4A1002F4" modified="2019-05-08" version="1">MEDNVELNCEVIGKPTPEIQWWGIEGNDSEVMSQLYDGARQQRVKINSSYNIDAKSSIKITNLSIEDTGTYECRASNDPDRNDLQKRPKIKWIRSQATLIVIEHPIIVTNPPILESGDILTETTLRCNLTNPPSSIEGHVWQKDGLDIPDTSDKATSTIMEYKLSAVDAKHSGAYSCHYFTTPAVNNTIHVKALPGVSSDKKSEYGNEGDVGVLTCKSSGYPLVENWMWSRLSAGGVQELIVNGTKKFQIKSSVNKTELRIHPLTIDADQGNYICNATNEIGTRGETLHLRVRGRFAALWPFLGIVAEVIVLVAIIFIYEKRRKPDEISDDDEQGSAPLKSNASMNHKDKNVRQRNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP34</accession>
    <name>A0A401NP34_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0007262</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002592">
        <property type="protein sequence ID" value="GCB62619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP34"/>
    <dbReference type="STRING" id="75743.A0A401NP34"/>
    <dbReference type="OMA" id="RCLMGYF"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF41">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="251"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB62619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="525" mass="59970" checksum="B25067606C69511D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP88</accession>
    <name>A0A401NP88_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002596">
        <property type="protein sequence ID" value="GCB62669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP88"/>
    <dbReference type="STRING" id="75743.A0A401NP88"/>
    <dbReference type="OMA" id="ISKSYMR"/>
    <dbReference type="OrthoDB" id="9927177at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23407" checksum="CCBF0F64C9D4C5F7" modified="2019-05-08" version="1">MGQRWSVQPRVSSQRVRRRNLRNFFWQFPVILVGGSAVGKTSIVLRLTEGTFREELQKTIGVDYYIHILETTPTVRVKLQVWDTAGGKEHRTITQSHLQAILGGLLVFDLTNRQTLDYLRNWLDETGPVLDQDECIFILVGHKSDLPAERQISQEEAEQIAADLGLRYIETSAKDGTNIHEAFLILASTIAQAVKTEVTEVKGGGFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPN4</accession>
    <name>A0A401NPN4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0014551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007848">
        <property type="protein sequence ID" value="GCB62851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPN4"/>
    <dbReference type="STRING" id="75743.A0A401NPN4"/>
    <dbReference type="OMA" id="RNLPVIW"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF8">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P25-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="5">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="184" mass="20394" checksum="1FA744C67BD7B764" modified="2019-05-08" version="1">MENYQKTKITELPCPHPIANLPKDIIEMKVKEGSKIRNLMGYAIGKMESASTTEILFTGTGKAVSKAITCVEIMKRRLKGLHQITKLFYKQVEELWEPIVSEAGLDSLTVKRNLPAICILLSKDTLHANEPGYQAPGSFDALWIHSLKEEALTQRKKRRGGDGLGKGGKHPGSGRGERPKKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPU0</accession>
    <name>A0A401NPU0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centrosomal protein of 164 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000013">
        <property type="protein sequence ID" value="GCB62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPU0"/>
    <dbReference type="STRING" id="75743.A0A401NPU0"/>
    <dbReference type="OMA" id="NMLTEKW"/>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051841">
        <property type="entry name" value="MT-Golgi_org_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902:SF27">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 164 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902">
        <property type="entry name" value="NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="953"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="142823" checksum="12C2665FD233A3B0" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPX3</accession>
    <name>A0A401NPX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ST3 beta-galactoside alpha-2,3-sialyltransferase 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0013129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006591">
        <property type="protein sequence ID" value="GCB62930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPX3"/>
    <dbReference type="STRING" id="75743.A0A401NPX3"/>
    <dbReference type="OMA" id="PESATYN"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008373">
        <property type="term" value="F:sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF8">
        <property type="entry name" value="TYPE 2 LACTOSAMINE ALPHA-2,3-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB62930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21680" checksum="BC0E81A8035C24C5" modified="2019-05-08" version="1" fragment="single">LNSGPVIGYEDDVGNKTTFRFSYPESVFSDHGQYDPNTTLVFVPFKALDLRWLKEVLLKQKVSMRGFWKKIPVQLIYKNSQIRILKPSIVQKAAFELLKLPTHVPWPKPPQYPTTGIIAITMALMMCDKVHIAGFKYDVYNPNSTLHYYGSETMSTMKKMVYHNITAEQMFLKKLKSSNTIFDLTGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQN3</accession>
    <name>A0A401NQN3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000018">
        <property type="protein sequence ID" value="GCB63175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQN3"/>
    <dbReference type="STRING" id="75743.A0A401NQN3"/>
    <dbReference type="OMA" id="CLIKFQK"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042475">
        <property type="entry name" value="VSIG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45046">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45046:SF1">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="78"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="201"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB63175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="376" mass="41701" checksum="7B8076A31BEDA1B0" modified="2019-05-08" version="1">MLLSRTLLDLVDKASSQTFDRQKLESHDEMDGRQINIQRIWEGPGLGLQQTKLLLRMPWKHIRLVLLLFLTSDFDAVQSISVTTDQPNVVVNVGNNATLDCTYRTYAESLFSLEWRFAPGPKADAKSDKILYYIDGKTYRIGHQANRIKLIDQNPTHGVASIRIENTQSSDTGRYSCDINNPPDTSGPSEAFINLVVQVPPSTPECKVIGGPYLRNNVTLLCRSEEGWPMPRYTWSEINPSAVKSSSKFTIKDSNKGSLFLRNLTMEHSGTYICVASNVLGERSCQLVLTVTVKNEAGAIVGAVIGTLVGLLLIAVVTYHLLRQKRKNPKVPVVGHELREDAVAPGKEANSHLLTSSVHSHETNTNSMNSKYNIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS48</accession>
    <name>A0A401NS48_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004034">
        <property type="protein sequence ID" value="GCB63677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS48"/>
    <dbReference type="OrthoDB" id="8784811at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB63677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="145" mass="16912" checksum="01A9316D2B2BB6DA" modified="2019-05-08" version="1">MQLLLSLMPHFLNIKKPKDKSNPAPVSTEAETLAYFDSVIADFDQESKPKVQPADDTYLDVDFVIASSTSEHSLHSNWLLKSPRRYSIDVAHLAKMDHLPRRHSDSIRMSFKRFERRPMYLPKLVESPMHTLRFKPKARNEDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS80</accession>
    <name>A0A401NS80_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004043">
        <property type="protein sequence ID" value="GCB63761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS80"/>
    <dbReference type="STRING" id="75743.A0A401NS80"/>
    <dbReference type="OMA" id="TTHANCY"/>
    <dbReference type="OrthoDB" id="10039395at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF125">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019491058" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53614" checksum="3DD586E0D648D689" modified="2019-05-08" version="1">MNASHRILVLTLTVCLIQGATAADGWNAEFPQSLSALQGRSVIFNCSFQYPYQEKIPAADITAKWLGAPCEFGSTVFYSNEKNEYTGVELIGDLSQKNCSLHISNVQTTHANCYCFRFEIKGKDNWTEKPCLNLSVYARPGKPIISSSTELVERMNSSLICSSSNVDRKAQASLNWYGIAGQAAGQCKGEAQSTLRSCHSFIPSYQDHNKIVKCSITYRKFPYSDEGNITLDVKYKPYDVNISQAGMSFICMAKANPQAQIIWNYTGNVKPVISDSFNNSTLTLQTTSDICISCQAQNKYGLIRSEQYCFKSTQPSFLPLVITGSVVGVLLLLGIVLLIRRKYFFRESKPEIESEQMFHNEIQHPKQERISVINGEYDNMCMSESPAVNKSAPRGDSADALVYASIQFGKKPAGLDPEHPKTEQAICSSIQQDNQVADSSVYENVEKYTTSSEEASISKKDSEDAILYAGIVFKDNPLQSTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSC0</accession>
    <name>A0A401NSC0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0014673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007964">
        <property type="protein sequence ID" value="GCB63747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSC0"/>
    <dbReference type="STRING" id="75743.A0A401NSC0"/>
    <dbReference type="OMA" id="KECYVEL"/>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF10">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="202"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="342"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB63747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="576" mass="64336" checksum="C70B087F6ED9949A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSW1</accession>
    <name>A0A401NSW1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Chaperonin 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0007462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homoheptamer arranged in a ring structure. 2 heptameric Hsp10 rings interact with a Hsp60 tetradecamer in the structure of a back-to-back double heptameric ring to form the symmetrical football complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002709">
        <property type="protein sequence ID" value="GCB63950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSW1"/>
    <dbReference type="STRING" id="75743.A0A401NSW1"/>
    <dbReference type="OMA" id="KVFYRQW"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="11156" checksum="48DE3C39CD13E7B4" modified="2019-05-08" version="1">MAGQAFKRFLPLFDRVLVERVAAETVTKGGIMLPEKSQGKVFQATVVAVGPDSRVKNGDVHPVNVQVGETVLLPEYGGTKVVLEDKDYYLFRDGDILGKYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTR4</accession>
    <name>A0A401NTR4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0004572</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71771"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:71773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:71769"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the STEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001358">
        <property type="protein sequence ID" value="GCB64252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTR4"/>
    <dbReference type="STRING" id="75743.A0A401NTR4"/>
    <dbReference type="OMA" id="EKRQFIQ"/>
    <dbReference type="OrthoDB" id="550646at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008823">
        <property type="term" value="F:cupric reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000051">
        <property type="entry name" value="STEAP2 metalloreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239:SF6">
        <property type="entry name" value="METALLOREDUCTASE STEAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="22">
        <location>
            <begin position="85"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="21">
        <location>
            <begin position="313"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB64252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61945" checksum="7A4B422474B2AA05" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTV9</accession>
    <name>A0A401NTV9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0013315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006754">
        <property type="protein sequence ID" value="GCB64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTV9"/>
    <dbReference type="STRING" id="75743.A0A401NTV9"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001135">
        <property type="term" value="P:regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="91"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58747" checksum="C1CEA880E56DFF78" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUC6</accession>
    <name>A0A401NUC6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008053">
        <property type="protein sequence ID" value="GCB64442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUC6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="71" mass="7910" checksum="61E52FFEA0C6B6CC" modified="2019-05-08" version="1">MLQSSASRSWMMGVILGAGVAVVLIATTILIVHRRLQERSVAIHIFLCWNLKAKDKKETKNADHCKTVLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUN5</accession>
    <name>A0A401NUN5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0000287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000055">
        <property type="protein sequence ID" value="GCB64552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUN5"/>
    <dbReference type="STRING" id="75743.A0A401NUN5"/>
    <dbReference type="OMA" id="VNCKHES"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000121">
        <property type="entry name" value="ETS translocation variant 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006715">
        <property type="entry name" value="ETS_PEA3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF196">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04621">
        <property type="entry name" value="ETS_PEA3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="208"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB64552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="350" mass="40827" checksum="46AB474AC325770E" modified="2019-05-08" version="1" fragment="single">LQDLSASVFYPACSQHRSLAQVPDNDEQFVPDFQSENLVFHGLPLKIKKEPQSPCSELSTACSHEQPFKFSYGEKCLYNVRFRRQLSEPCHSFPPPHGLPREGRPMYQRQLSEPNIPFPPQGFKQEYHDPVYEHATMISAPANQSFPQPMMIKQEPRDYAYDSGCMYEKGPRHFYDDTCVVPEKFDSDIKQEPGVYREGPTYQRRGSLQLWQFLVALLDDPANSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPVLKTDIERHINEEDTVPLSHFDENMAYIQDSGCCNPHPYNEAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVC2</accession>
    <name>A0A401NVC2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0007592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01002790">
        <property type="protein sequence ID" value="GCB64833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVC2"/>
    <dbReference type="STRING" id="75743.A0A401NVC2"/>
    <dbReference type="OMA" id="VDEYCAW"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000096">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000006">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0834">Unfolded protein response</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="12">
        <location>
            <begin position="146"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB64833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="345" mass="38464" checksum="1A161E548B13C615" modified="2019-05-08" version="1">MKGVETQPPVGGGGRRWSRPRDRRIWVGGAYVTSVLALLKNTMLRLRCKAKNGTHLMQGLTSVSCVQELKDKVEELTGIPCALQKIMVGFPPSNLELRNGELPLKDCPIKSGDTLIVEEERDTLKIKASASKFGAKSSDKDAFPQLARHVVPADNSCLFTSIHYVVEGGVCEPTCAPEMRNLIAQIVASDPDSYTEAVLGKSNWDYCNWIRQNDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDVGYTKRVLLLYDGIHYDPLNRQFEDPETPPQTIFSTADDVVLAQALELADEARRKRQFTDLNKFTLRCVICQKGLVGQLEAREHAKETGHTNFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWC0</accession>
    <name>A0A401NWC0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Janus kinase and microtubule-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0000390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the JAKMIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000071">
        <property type="protein sequence ID" value="GCB65170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWC0"/>
    <dbReference type="OMA" id="KFRVNDY"/>
    <dbReference type="OrthoDB" id="6424487at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024836">
        <property type="entry name" value="JAKMIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031994">
        <property type="entry name" value="JAKMIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18935">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18935:SF7">
        <property type="entry name" value="JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16034">
        <property type="entry name" value="JAKMIP_CC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Janus kinase and microtubule-interacting protein C-terminal" evidence="5">
        <location>
            <begin position="439"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="400"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="708"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB65170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="791" mass="93262" checksum="9C740273371037F2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXU5</accession>
    <name>A0A401NXU5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tribbles homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0007771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002869">
        <property type="protein sequence ID" value="GCB65692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXU5"/>
    <dbReference type="STRING" id="75743.A0A401NXU5"/>
    <dbReference type="OMA" id="CQDQLVP"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000153">
        <property type="entry name" value="Tribbles homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000253">
        <property type="entry name" value="tribbles homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF15">
        <property type="entry name" value="TRIBBLES HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB65692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="346" mass="39091" checksum="39FA7AC27B8DDE56" modified="2019-05-08" version="1">MSIQRSSPISIVRYGRSRHKTHHEYEELSCVRTSDCSQSFSPNLGSPTPPETPNSSHCISQIGQYLLLEPLEGDHVLGAVHLHSGEELVCKVFDVGRYQETLAAYFYLSAHESINQITEILLGEQRAYVFFEKSHGDMHSFVRTCKRLKEDEAARLFYQITSAVAHCHDNGVVLRDLKLRKFVFKDEERTLVKLESLEDACILNGEVDALSDKHGCPAYVSPEILNTNGSYSGKAADVWSLGVMLYTMLVGRYPFHDVEPSSLFSKIRRGQFNIPETLSPRAKCLIRSILRREPLERLTSREILDHPWFASDFASSSSGYGANEKEAVDQLVPDVNMDVELDPFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXY0</accession>
    <name>A0A401NXY0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcriptional repressor CTCF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">11-zinc finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">CCCTC-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">CTCFL paralog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0009998</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CTCF zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004224">
        <property type="protein sequence ID" value="GCB65731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXY0"/>
    <dbReference type="STRING" id="75743.A0A401NXY0"/>
    <dbReference type="OMA" id="ACKECTY"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000222">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000283">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000373">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000420">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000049">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000123">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF81">
        <property type="entry name" value="CCCTC-BINDING FACTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB65731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="558" mass="64867" checksum="D1A79A171201AB2B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY21</accession>
    <name>A0A401NY21_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein sprouty homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0004858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sprouty family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001460">
        <property type="protein sequence ID" value="GCB65771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY21"/>
    <dbReference type="STRING" id="75743.A0A401NY21"/>
    <dbReference type="OMA" id="CNTRAPG"/>
    <dbReference type="OrthoDB" id="10038884at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365:SF10">
        <property type="entry name" value="PROTEIN SPROUTY HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
        <property type="entry name" value="SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB65771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="324" mass="35633" checksum="7EA45F01914766CC" modified="2019-05-08" version="1">MEARIQHGGGGSLVVIQQPSLDSRQRLDYERELQRTAILSLDQIKAIRTSNEYTEGPAIAKKATSLSSSRITQRHDKHERTHEVIPINVNNNYEHRSTHHTHAGHHSSTRMPVLSRSTSTGSAASSGSNSSASSEQGLLGRSPPIRLTSSHHRADRTIRTQPKASACTTEVPKCLGKEDLAKHRFICEQCGKCKCRECTAPRTLPSCLACNKQCLCSAESMVEYGTCMCLVKGIFYHCSNDDEDSCADNPCSCSHSHCCSRFLCMGLMSLFLPCLLCYLPAKGCIKLCQGCYDRVNRPGCRCKNSNTVYCKLKSCPTPGEDKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYY7</accession>
    <name>A0A401NYY7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC1 domain family member 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Akt substrate of 160 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0000546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000098">
        <property type="protein sequence ID" value="GCB66083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYY7"/>
    <dbReference type="STRING" id="75743.A0A401NYY7"/>
    <dbReference type="OMA" id="YTPRRRM"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000003">
        <property type="entry name" value="Putative TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2750:FF:000002">
        <property type="entry name" value="TBC1 domain family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021785">
        <property type="entry name" value="DUF3350"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF14">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11830">
        <property type="entry name" value="DUF3350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="407"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="760"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB66083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="801" mass="90259" checksum="992803DFC6D3EC0C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZE3</accession>
    <name>A0A401NZE3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0010070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004269">
        <property type="protein sequence ID" value="GCB66225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZE3"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB66225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="8934" checksum="5943DBFE8ABBA5BD" modified="2019-05-08" version="1">MAGARQSGFPIGWSPAKRLSYWLEPSYATFLLADGCFLSRMRILGVSIGAGAAPFQRYLDSSLQLGLGTATSMVNIDCSKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZP7</accession>
    <name>A0A401NZP7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-related protein Rab-21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0004950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001497">
        <property type="protein sequence ID" value="GCB66341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZP7"/>
    <dbReference type="STRING" id="75743.A0A401NZP7"/>
    <dbReference type="OMA" id="IVXMIET"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04123">
        <property type="entry name" value="Rab21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000550">
        <property type="entry name" value="ras-related protein Rab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041833">
        <property type="entry name" value="Rab21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB66341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="214" mass="23650" checksum="F850652606F043CF" modified="2019-05-08" version="1">MAAAATSYCFKVVLLGEGCVGKTSLVLRYCENKFSDKHITTLQASFLTKKLNISGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRRMLGSEICLCIVGNKTDLEKDRNVSVEEAEEYAVSVGAKHFHTSAKVNKGIEELFLDVCKKMLEVAQAEEAARGNNPSRAVHTRRGVQIIDDEPQPLSNGGCCSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P020</accession>
    <name>A0A401P020_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0007879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002937">
        <property type="protein sequence ID" value="GCB66453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P020"/>
    <dbReference type="STRING" id="75743.A0A401P020"/>
    <dbReference type="OMA" id="DIHETIM"/>
    <dbReference type="OrthoDB" id="9930943at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057456">
        <property type="entry name" value="Znf_C17orf113"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF11">
        <property type="entry name" value="PR_SET DOMAIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25431">
        <property type="entry name" value="zf-C17orf113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C17orf113 probable zinc finger" evidence="3">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="613"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB66453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="732" mass="83676" checksum="2C23ABB4EB285081" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1M4</accession>
    <name>A0A401P1M4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004342">
        <property type="protein sequence ID" value="GCB67045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1M4"/>
    <dbReference type="STRING" id="75743.A0A401P1M4"/>
    <dbReference type="OMA" id="LENHHKQ"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="14350" checksum="2A3B6FF3D7B35C2E" modified="2019-05-08" version="1" fragment="single">MRPSEWGQPAFDLRAPLLRFAVQPALGRRSQWEKMAATQDVHVRICAQEIIKYDLEIKALVQDIRDSPGPLSLLTELNAKVKEMFQQLRLRIQDLEQMAKEQDKESDKQILLAEVENHRKQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P226</accession>
    <name>A0A401P226_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alpha-mannosidase</fullName>
            <ecNumber evidence="17">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0013663</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01007078">
        <property type="protein sequence ID" value="GCB67143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P226"/>
    <dbReference type="STRING" id="75743.A0A401P226"/>
    <dbReference type="OMA" id="ITHYYAM"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000009">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000002">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF57">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="18">
        <location>
            <begin position="458"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB67143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1105" mass="126895" checksum="4142716C5DFEE33D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P280</accession>
    <name>A0A401P280_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0013673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007085">
        <property type="protein sequence ID" value="GCB67210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P280"/>
    <dbReference type="STRING" id="75743.A0A401P280"/>
    <dbReference type="OMA" id="WMFWAML"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB67210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="561" mass="63267" checksum="3F64A4BB3BA29E1A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P348</accession>
    <name>A0A401P348_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007123">
        <property type="protein sequence ID" value="GCB67575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P348"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB67575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="148" mass="13429" checksum="D68CFCFB35EB6D12" modified="2019-05-08" version="1">MNTGRTDVEAKLHYFVADVGVDAAVGPVGVEADAAGVDDVADSAVELDIVVGSAVDAEAGSAVGAEAGSAVGAEAGSAVGAEAGSAVGAEARSAVGGMARSAVGGMARSAVGAEAGSAVGGVDAVVVSAVDDDAAVVSAGVAVSAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P387</accession>
    <name>A0A401P387_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0000751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000152">
        <property type="protein sequence ID" value="GCB67615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P387"/>
    <dbReference type="STRING" id="75743.A0A401P387"/>
    <dbReference type="OMA" id="DAKAKPC"/>
    <dbReference type="OrthoDB" id="9333799at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1080" mass="125251" checksum="4B308CDA9E5200EB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P3T1</accession>
    <name>A0A401P3T1_SCYTO</name>
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        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="75743.A0A401P3T1"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
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        <property type="entry name" value="TRC8_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF191">
        <property type="entry name" value="RING FINGER PROTEIN 145 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13705">
        <property type="entry name" value="TRC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="166"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="197"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="354"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="392"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="427"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
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            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB67771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="769" mass="86428" checksum="EB7A5E2C2CE8F952" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P428</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
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            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401P428"/>
    <dbReference type="OMA" id="HGEMTES"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="398" mass="47441" checksum="1A6CFFE1C3D042B4" modified="2019-05-08" version="1">MITQDTVTQDTESQDTETQDTETQDTETQDTETQDKETQDKETQDTETQDTETQDTETQDSETQDRDTQDKETQDTETQDTETQDTETQDTETQDTDTQDRETQDRETQDKETQDTETQDTETQDRDTQDRETQDTETQDKETQDRETQDKETQDTETQDTETQDSETQDRDTQDRETQDRETQDKETQDTETQKPRTQKPRTQKPRTQKPRTRTPRTEKPRTEKPRTEKPRTQKPRIRKPRTRKPRTQKPRIRKTRTRKPRTRKPRTQKARTQKPRTRTPRTEKPRTKKPRTEKPRTQKPRIRKPRTRKTRTQKPRTQKPRTRKPRTRKPRTGTPRTEKPRTVKPRTRKPNLLQLAKGEERRDEIGQNRTKSDEIGEVQKPSEQVGDDQGESEDVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P517</accession>
    <name>A0A401P517_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">POPDC1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0010360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the popeye family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004451">
        <property type="protein sequence ID" value="GCB68186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P517"/>
    <dbReference type="STRING" id="75743.A0A401P517"/>
    <dbReference type="OMA" id="TAETECC"/>
    <dbReference type="OrthoDB" id="425611at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006916">
        <property type="entry name" value="POPDC1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055272">
        <property type="entry name" value="POPDC1-3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101">
        <property type="entry name" value="POPEYE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101:SF15">
        <property type="entry name" value="POPEYE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04831">
        <property type="entry name" value="POPDC1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="POPDC1-3" evidence="8">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="343" mass="39431" checksum="90215097323FE7D3" modified="2019-05-08" version="1">MLRDNSSLIETILYDNLECNVLKNGSEGAIYHLANVMFTLGYMSGSGFFGLVYIFSLLGVGFFIQSIWGWVDACGVDIFMWCLLLFVLCLLQLAHIGYRLRKVTFEEDFANLYKALFRPLDVPLTAYKEIVRCCDAEVTSLACDQNYAVEGKTAIDRLSLLLAGRVRVTLDHQFLHYIFPYQFLDSPEWESLRPNEEGNFQVTLTAETECCYVTWKRRKLYLLLAKHHYIARLFSVMLGNDIADKLYSLIDKLYCRGGVRYDIRLPSLYHVLAPPVEAEKEKIAESPHHVPQSSFKPQESPFKKPWPDSNDLIGEDSTSLVLEDFADMTGSFMEYTSEREYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7V1</accession>
    <name>A0A401P7V1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004550">
        <property type="protein sequence ID" value="GCB69188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7V1"/>
    <dbReference type="STRING" id="75743.A0A401P7V1"/>
    <dbReference type="OMA" id="MCEDTER"/>
    <dbReference type="OrthoDB" id="6482909at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18469">
        <property type="entry name" value="BACK_KLHL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030582">
        <property type="entry name" value="KLHL30_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF398">
        <property type="entry name" value="KELCH-LIKE PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="94"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="648" mass="73264" checksum="D3D594464691CAE9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7Y5</accession>
    <name>A0A401P7Y5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 26 member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0012385</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>bromide(in) + chloride(out) = bromide(out) + chloride(in)</text>
            <dbReference type="Rhea" id="RHEA:75335"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>iodide(in) + chloride(out) = iodide(out) + chloride(in)</text>
            <dbReference type="Rhea" id="RHEA:72379"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrate(in) + chloride(out) = nitrate(out) + chloride(in)</text>
            <dbReference type="Rhea" id="RHEA:75339"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:72275"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>oxalate(out) + 2 chloride(in) = oxalate(in) + 2 chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:75095"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>sulfate(out) + 2 chloride(in) = sulfate(in) + 2 chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:75091"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005973">
        <property type="protein sequence ID" value="GCB69245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7Y5"/>
    <dbReference type="STRING" id="75743.A0A401P7Y5"/>
    <dbReference type="OMA" id="YHLARIT"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000015">
        <property type="entry name" value="Sulfate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="19">
        <location>
            <begin position="549"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB69245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="723" mass="79784" checksum="21D682C2BBD1BD58" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8E2</accession>
    <name>A0A401P8E2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007335">
        <property type="protein sequence ID" value="GCB69363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8E2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB69363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7572" checksum="5E8AD29F2EEE51AD" modified="2019-05-08" version="1">MGKRIPSAASGTSPPCRRFLLAPFPWTRACLLPQEPEKGHRCLEKYLGLVARLEMRLQHETHRGGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8K0</accession>
    <name>A0A401P8K0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrolipoamide dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0013974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007347">
        <property type="protein sequence ID" value="GCB69465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8K0"/>
    <dbReference type="STRING" id="75743.A0A401P8K0"/>
    <dbReference type="OMA" id="INHEAEG"/>
    <dbReference type="OrthoDB" id="8638425at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="9">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="10440" checksum="DA03C93F93A563AB" modified="2019-05-08" version="1">MGIPYKIGKFPFAANSRAKTNNDTDGLVKILSHKETDRMLGAHILGSGAGEMINEATLAMEYGASCEDVARVCHAHPTVSEAFREANIAAAFGKAINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9K5</accession>
    <name>A0A401P9K5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dr1-associated corepressor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dr1-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Negative cofactor 2-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0010621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Heterodimer with DR1. Binds BTAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004621">
        <property type="protein sequence ID" value="GCB69770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9K5"/>
    <dbReference type="STRING" id="75743.A0A401P9K5"/>
    <dbReference type="OMA" id="APAPMAC"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000032">
        <property type="entry name" value="dr1-associated corepressor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="14">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB69770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="215" mass="23752" checksum="256BA1CDD4A13A21" modified="2019-05-08" version="1">MPSKKKKYNARFPPARIQKIMQTDEDIGKFAAAVPVIISQALELFLDSLLTKACHVTQLRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGENEDNHMEGDKAPQRGRKPGSGQRNTNGGVGSKVKDNKQSSTESEQEDESEECEMDEEEMSRSSTDKPGDPIQSPLSLFSTPLPTLPMPMCSPVMSNLPMPAPAPMACNEDGKEDDDYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9M0</accession>
    <name>A0A401P9M0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EVA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EVA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001737">
        <property type="protein sequence ID" value="GCB69773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9M0"/>
    <dbReference type="STRING" id="75743.A0A401P9M0"/>
    <dbReference type="OMA" id="ISCAPHP"/>
    <dbReference type="OrthoDB" id="8956386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052461">
        <property type="entry name" value="EVA1_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039500">
        <property type="entry name" value="EVA1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48422:SF2">
        <property type="entry name" value="PROTEIN EVA-1 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48422">
        <property type="entry name" value="PROTEIN EVA-1 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14851">
        <property type="entry name" value="FAM176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EVA1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB69773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="174" mass="19739" checksum="71B6DA1156276207" modified="2019-05-08" version="1">MDVPKAEVALITNSIQAYMHIKANPEKAALYFITGVCFGLILTLCLLVIRISCHTRSRTTAPVKRKVEEGSEEEDDEEDEEEDELDSVPPTTTDMTLANHTQTNTSSNVNVFTSAEELERAQLLEERERIIREIWRSGQPDILGSGCHQFELELLPNGGQREHRTWSPNSEHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC21</accession>
    <name>A0A401PC21_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0005748</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001834">
        <property type="protein sequence ID" value="GCB70671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC21"/>
    <dbReference type="STRING" id="75743.A0A401PC21"/>
    <dbReference type="OMA" id="KCDHNGF"/>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062158">
        <property type="term" value="F:chloride:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002249">
        <property type="entry name" value="CIC-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01118">
        <property type="entry name" value="CLCHANNEL7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="741"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB70671.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="805" mass="88558" checksum="C9683E46DF590DB3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCD4</accession>
    <name>A0A401PCD4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="42">Triacylglycerol lipase</fullName>
            <ecNumber evidence="42">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="42">Pancreatic lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="ORF">scyTo_0005776</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="44 45" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39955"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:39956"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40475"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:35020"/>
            <dbReference type="ChEBI" id="CHEBI:76478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40476"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:76978"/>
            <dbReference type="ChEBI" id="CHEBI:88066"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:47865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:88153"/>
            <dbReference type="ChEBI" id="CHEBI:88155"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:48025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + dodecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48516"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:90337"/>
            <dbReference type="ChEBI" id="CHEBI:90359"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:48517"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoyl-3-beta-D-galactosyl-sn-glycerol + dodecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48540"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:90340"/>
            <dbReference type="ChEBI" id="CHEBI:90515"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:48541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:90457"/>
            <dbReference type="ChEBI" id="CHEBI:90768"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:48693"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:90453"/>
            <dbReference type="ChEBI" id="CHEBI:90769"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:48697"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48536"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:90342"/>
            <dbReference type="ChEBI" id="CHEBI:90514"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:48537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13189"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15754"/>
            <dbReference type="ChEBI" id="CHEBI:17615"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.26"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13190"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + H2O = acyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48372"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28396"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:90310"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:48373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:84465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:44665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75937"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:47869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1-&gt;6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:90463"/>
            <dbReference type="ChEBI" id="CHEBI:90774"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:48709"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:90477"/>
            <dbReference type="ChEBI" id="CHEBI:90770"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:48701"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycerolipid metabolism; triacylglycerol degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="18">Glycolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 42">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Zymogen granule membrane</location>
            <topology evidence="19">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 41">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="44">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="42"/>
    <dbReference type="EMBL" id="BFAA01001850">
        <property type="protein sequence ID" value="GCB70786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCD4"/>
    <dbReference type="STRING" id="75743.A0A401PCD4"/>
    <dbReference type="OMA" id="WSGTRDF"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042589">
        <property type="term" value="C:zymogen granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047714">
        <property type="term" value="F:galactolipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000003">
        <property type="entry name" value="Triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF165">
        <property type="entry name" value="PANCREATIC LIPASE-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 39" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13 40 42" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 42" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 42" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 39" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="45" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 42" id="KW-0964">Secreted</keyword>
    <keyword evidence="42" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="42">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018818461" description="Triacylglycerol lipase" evidence="42">
        <location>
            <begin position="18"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="43">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="38">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="38">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="38">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="21"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="317"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="40">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00049352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00049420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="RuleBase" id="RU362046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="SMART" id="SM00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="EMBL" id="GCB70786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="471" mass="52471" checksum="463E210CF387B074" modified="2019-05-08" version="1">MLWLIIVAFTLGNTVKAAEVCFDKLGCFTDDVPWGGTKQRPIKKLPWFPENINTRFLLWTRQNPAAFQEITAINPSTIKSSNFDPTHKTRFIIHGYIDKGEESWLSDMCKAMFEVEDVNCICVDWVRGSRTLYDQAVNNARVVGAEMAYLIDVLEKDFNYTRSEVHIIGHSLGGHAAGETGRRIPGIGRITGLDPAKPFFKNTPIEVRLDISDAVFVDVIHSNGAPLIPYLGFGLFEPVGHLDFYPNGGELMPGCDKNIISTIIDVNGIWEGTRNFAACNHLRSYKYYTESITTRNGFVGIPCTNYDDFTAGSCSSCPTEGCPTMGHFADTYFFGNGTTEPKFFLNTGAAPSFARWRYKVSVQITCTREIRGFFKIALYGSKVNSRQYQIAKALLQSGKTFTADIDLENDIGEIIKVKFLWNNLFPNLFGPKIGAETVTILRIYDQQTFKFCGTGGVGEDVLQTVLPCSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCP6</accession>
    <name>A0A401PCP6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ADP-ribosylation factor 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0008706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with ARL14EP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003382">
        <property type="protein sequence ID" value="GCB70885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCP6"/>
    <dbReference type="STRING" id="75743.A0A401PCP6"/>
    <dbReference type="OMA" id="INYRELR"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB70885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="18436" checksum="48003F9D31B209EF" modified="2019-05-08" version="1">MRILMLGLDAAGKTTALYKLKLRKPVSTIPTVGFNVETVTYRKVCFNVWDVGGQDKIQPLWRHYYTGTQGLIFVVDCADRDRIDEARQELYRIINYRELRDAIIMIFANKQDLPDAMKPHETQEKLGLTRIRDRNWYVQPSSATTGDGLFEGLTSNYKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCR4</accession>
    <name>A0A401PCR4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone PARylation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0008714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003384">
        <property type="protein sequence ID" value="GCB70905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCR4"/>
    <dbReference type="STRING" id="75743.A0A401PCR4"/>
    <dbReference type="OMA" id="NEAHLAN"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB70905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39283" checksum="06CBC27F6D16E7A0" modified="2019-05-08" version="1">MAGRGKRKAASRSSESKNPVAEDGKKNRGDNAGIPEEVRRDVQDLYKLQMPEDFYHFWEFCEKLNPENPCEALNLSLGLRLVGPFDILAGKPKGTKNPQPNYLLHWRYFYDPPEFQTVINGDSETQYHLGYFRDTPEELPVFVGANVAKNGCSIAQMGDNLFSAVNLLLSRRLKEMSNKSPSSVLKELETKLTALAKKLGYSLEQKTKEMKQRDRKIATRTFHGAGLIVPIDKTGVGYRELPETDGSLKKICKAIVEAPSDEARIKAFAPVQEIITYIQFANDECDYGMGYELGIDLFCYGSHYFHKVVQQLLPLAYKLLKRHLFAEIIEIHLSNRTWDDLDQLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE18</accession>
    <name>A0A401PE18_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">WWC3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0005931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001926">
        <property type="protein sequence ID" value="GCB71400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE18"/>
    <dbReference type="STRING" id="75743.A0A401PE18"/>
    <dbReference type="OMA" id="LDNAMEM"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046621">
        <property type="term" value="P:negative regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035330">
        <property type="term" value="P:regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08680">
        <property type="entry name" value="C2_Kibra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000001">
        <property type="entry name" value="Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037771">
        <property type="entry name" value="C2_WWC"/>
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        <property type="entry name" value="WW_dom"/>
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        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
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    <dbReference type="InterPro" id="IPR057747">
        <property type="entry name" value="WWC1_hairpin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF25">
        <property type="entry name" value="PROTEIN WWC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25802">
        <property type="entry name" value="WWC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="679"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="313"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="843"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB71400.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1171" mass="133069" checksum="B7F1C3F71C3B9ACA" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF26</accession>
    <name>A0A401PF26_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0006046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001973">
        <property type="protein sequence ID" value="GCB71709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PF26"/>
    <dbReference type="STRING" id="75743.A0A401PF26"/>
    <dbReference type="OMA" id="NEGMRIC"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="UniPathway" id="UPA00062"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB71709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="165" mass="18851" checksum="1662F281BE82427D" modified="2019-05-08" version="1">MPEVTRAVTNVICLLCFNSTYEKGDPEFEKMLEYSQGIVNTVGKDSLIDIFPWLQLFPNEDLHTLKQCIAVRDSILQKKFEEHKANYSSDSINDLLDALLKAKMNAENNNSSAYAERLTEDHLLMTVADIFGAGVETTSTTLAWMIVYLLHYPEVEETFKDIQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF87</accession>
    <name>A0A401PF87_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0006060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001979">
        <property type="protein sequence ID" value="GCB71758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PF87"/>
    <dbReference type="STRING" id="75743.A0A401PF87"/>
    <dbReference type="OMA" id="ISSCRTY"/>
    <dbReference type="OrthoDB" id="8407241at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000001">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF107">
        <property type="entry name" value="CRYGMX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB71758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="256" mass="31746" checksum="2711853D85F7565F" modified="2019-05-08" version="1">MAKIIFYEDRNFQGRHYECSNDCADLSPYFSRCNSMRVMSDWWVMYERPNYMGYQYVLSRGEYPDYQRWMGFNDNIGSCRTYPYIIFYEDRNFQGRHYECSSDCADLSSYFSRCNSMRVMSDWWVMYERPNYMGYQYVLSRGEYPDYQRWMGFNDSISSCRTYPYYRGGNYRMRIYERPDFGGQMMEFMDDCPSVYDRFRYRDIYSCHVMDGYWIFYEHPNYRGRQYFMRPGEYRRYSDWGGYNSTIGSFRRMRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFF6</accession>
    <name>A0A401PFF6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0001720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000398">
        <property type="protein sequence ID" value="GCB71851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFF6"/>
    <dbReference type="STRING" id="75743.A0A401PFF6"/>
    <dbReference type="OMA" id="IWHSAIQ"/>
    <dbReference type="OrthoDB" id="9925886at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000188">
        <property type="entry name" value="Interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF10">
        <property type="entry name" value="X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB71851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="14191" checksum="E4E582E3C91915CA" modified="2019-05-08" version="1">MSLTVAENDSGLCYSSMIRNLEKAEITKSKELLCREIEDFITEDQDLDIVWYKECLPKSWRSTVLQKRNTLVIQKVQEDDLGNYTCELKYKNKLVRRTTELRITEGALPFRINEDLKPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH00</accession>
    <name>A0A401PH00_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002095">
        <property type="protein sequence ID" value="GCB72410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH00"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8213" checksum="BC4D37DCEB3547A3" modified="2019-05-08" version="1">MATQTTPFQGVGGGTHIEQELRALGSGEGHPISIVLKMTLAFNFCLPAGDLCCLSRCRTFSTDPKDIQITLNVRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHI8</accession>
    <name>A0A401PHI8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IF rod domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0006360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002132">
        <property type="protein sequence ID" value="GCB72554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHI8"/>
    <dbReference type="STRING" id="75743.A0A401PHI8"/>
    <dbReference type="OMA" id="RDETEGM"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050405">
        <property type="entry name" value="Intermediate_filament"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652">
        <property type="entry name" value="GLIAL FIBRILLARY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652:SF21">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 13-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="27"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="31"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB72554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="260" mass="29967" checksum="6211F279827B61A2" modified="2019-05-08" version="1" fragment="single">MSAGDDPLDFSLLDAVSDEFKISRTDEKEKLIDLNNRFVNYIEKVRSVEQQNKMLNAELQELKGKGNSKIGSIYEQELKKLRQEVDQISKDKAKIEVERDNLLDDVHTLKAKLRSELQQREEAESNLTDFREDVDEATLACADLQRKIDALQDEIIFLKKLHEEEIRNLESQEQNQQAKIEMDVARPDLSSALQEARSQFDKLASRNISETETWYKSKISDLSQNIARNNEALRLAKQEANDNRREAQTLKCEVEALKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHR5</accession>
    <name>A0A401PHR5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0002113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000506">
        <property type="protein sequence ID" value="GCB72651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHR5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="105" mass="11605" checksum="6DE124CB15C63E9A" modified="2019-05-08" version="1">MGRTWLKRIKPDWADVNLMSDSEAGPTKILKNQKVAAAENALTAAVAKAQRSSAGSKTTKAQAAVTNVGQGRETKGEELTEDADECFVKNECQRYTEQFREDIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ26</accession>
    <name>A0A401PJ26_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0002363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000593">
        <property type="protein sequence ID" value="GCB73129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PJ26"/>
    <dbReference type="OMA" id="XVRAARE"/>
    <dbReference type="OrthoDB" id="6084525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000030">
        <property type="entry name" value="Kinase D-interacting substrate of 220 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000195">
        <property type="entry name" value="Kinase D-interacting substrate of 220 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="4">
        <location>
            <begin position="564"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="5">
        <location>
            <begin position="1278"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1604"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1658"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1765"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1664"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1785"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1812"/>
            <end position="1827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB73129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1882" mass="207793" checksum="11BD7913C90A5096" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN59</accession>
    <name>A0A401PN59_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0003663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001022">
        <property type="protein sequence ID" value="GCB74572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN59"/>
    <dbReference type="STRING" id="75743.A0A401PN59"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031852">
        <property type="entry name" value="Vik1/Cik1_MT-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF65">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16796">
        <property type="entry name" value="Microtub_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="475"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="549"/>
            <end position="556"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB74572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="589" mass="67597" checksum="7688F83E572FCCAA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQF1</accession>
    <name>A0A401PQF1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0018207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012458">
        <property type="protein sequence ID" value="GCB75354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQF1"/>
    <dbReference type="STRING" id="75743.A0A401PQF1"/>
    <dbReference type="OMA" id="QTMIANT"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF3">
        <property type="entry name" value="MYOSIN VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB75354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="11684" checksum="5E56D08C194751A1" modified="2019-05-08" version="1" fragment="single">VRQNPAERNYHIFYALLAGADPQQKEALHLSEAECYRYLGQSGCVRDENLDDNLVFEKVMDAFLVMGFDREEIQDVFKLLSGVLRLGNIEFVTAGGAQISTKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQH7</accession>
    <name>A0A401PQH7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Arrestin domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0016413</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009899">
        <property type="protein sequence ID" value="GCB75370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQH7"/>
    <dbReference type="STRING" id="75743.A0A401PQH7"/>
    <dbReference type="OMA" id="IHAGRHE"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000005">
        <property type="entry name" value="Arrestin domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000007">
        <property type="entry name" value="Arrestin domain-containing protein 3 mRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF49">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="15">
        <location>
            <begin position="187"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB75370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="417" mass="46920" checksum="D683290F6BDD9611" modified="2019-05-08" version="1">MVLGKVKSFTISYDCPNDNNIPVYASGDSVSGRVIIEVTGEIRVRSLTIHARGQAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDLLIGHERDDDDSEEDLTTIPSGRHEYPFSFELPQIPLATSFEGKYGSVRYWVKAELHRPWMLVMKVKKEFTVFEHIDINTPLLLSPQAGTKEKTLCCWFCSSGPISLSAKIERKGYTPGESIHIFAEIENCSSRMVVPKAAIYQTQTFYAKGKMKEVKHLVANLRGESLSSGKTESWNGKLLKIPPVSPSIVDCSIIRVEYSLTVYVDIPGAMNLTLNLPLVIGTIPLHPFGSRTSSVSSQCSVNLNWLSLALPERPEAPPSYAEIVSEQQRRNNFATIAVRDELERVFEGPLFAYIQEFRYQPPPVYSEIDPNPDQANQNREINPCCSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR20</accession>
    <name>A0A401PR20_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0020370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016380">
        <property type="protein sequence ID" value="GCB75563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR20"/>
    <dbReference type="STRING" id="75743.A0A401PR20"/>
    <dbReference type="OMA" id="HICAATV"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB75563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="66" mass="6877" checksum="D7D1182BAC2659A9" modified="2019-05-08" version="1" fragment="single">NILEKEGVRSLFRGLGPNLVGVAPTRAIYFAAYASAKEGFSRVLEPGTAMLHICAATVAGISLAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR42</accession>
    <name>A0A401PR42_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009936">
        <property type="protein sequence ID" value="GCB75598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR42"/>
    <dbReference type="OrthoDB" id="8916439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="152" mass="17677" checksum="AE7DA21DEDF5AEB5" modified="2019-05-08" version="1">MTDPRARAPAVWAIRQVERRAGRPHGDGRLVLVAIRYNLRRELAFGMEVKRLLELRLRQLERTLRGKEERIVQLETENALLHLKLAKCRGSVKDSKEETTCLRRHLEDVRNIQKNTGCQLSQLFAGVKKTTHLRKKGNVYRFSRSLLANPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRC3</accession>
    <name>A0A401PRC3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Signal-induced proliferation-associated 1-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017691">
        <property type="protein sequence ID" value="GCB75672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRC3"/>
    <dbReference type="STRING" id="75743.A0A401PRC3"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021818">
        <property type="entry name" value="SIPA1L_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11881">
        <property type="entry name" value="SPAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Signal-induced proliferation-associated 1-like protein C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB75672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="177" mass="19518" checksum="A3CB963E7282C6B9" modified="2019-05-08" version="1" fragment="single">RHHSDVCEITQTKLRGSVRDLRSPKRSSKSTIEEDLKKLINLDSPPPDMGKDGKPSLPDTPTTRKPLHRTLSDESIYSGQREPSFSNTHASLLDQALPNDVLFSSTHPSLHYTLPGLELSASDGSLSDIHERRRQPLPDPGLMPLPDTAMGLEWSNLVDAAKAFEGQNLCVVVAVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSE7</accession>
    <name>A0A401PSE7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0015420</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008742">
        <property type="protein sequence ID" value="GCB76066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSE7"/>
    <dbReference type="STRING" id="75743.A0A401PSE7"/>
    <dbReference type="OMA" id="YLMFWIF"/>
    <dbReference type="OrthoDB" id="5966748at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004949">
        <property type="term" value="F:cannabinoid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000072">
        <property type="entry name" value="Cannabinoid receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000810">
        <property type="entry name" value="Canbinoid_rcpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002230">
        <property type="entry name" value="Cnbnoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00522">
        <property type="entry name" value="CANABINOID1R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00362">
        <property type="entry name" value="CANNABINOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 18" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="14 18" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="155"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB76066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="494" mass="55202" checksum="1E64A8424AAC1AC1" modified="2019-05-08" version="1" fragment="single">FFPPIACWKETAHTFPTLKAMMKSLLEALSDTTFRTITTDLLYIASNEVQYDDTKVDLNMTKLGYVTQNLHSSLGKGNAYLEKMTAGEELLSNANVYDSMNATNYLYNQSIMNDESTITCGENFMDMECFMILTPSQQMAVAVLALTLGTFTVLENVLILCVIIRSRSLRYKPSYHFIGSLAVADLLGSVIFVYSFVDFHVFQRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHKPLAYKRIVTRPKAVIAFTVMWTVSIIIAVLPLLGWNCKKLNSVCSDIFPLIDETYLMFWIGVTSILLLFIIYAYVYILWKAHVHAVRMIQRGTQKSIIVQVTEGGKVQTVRLDQTRMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLVKTIFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFCSCKGASAQPLENSLESDCQQKQGNHPGTMQTAARTCIKSTVKVAQVAISVSTETSAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSV1</accession>
    <name>A0A401PSV1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0020987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017815">
        <property type="protein sequence ID" value="GCB76214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSV1"/>
    <dbReference type="STRING" id="75743.A0A401PSV1"/>
    <dbReference type="OMA" id="FGCLAMD"/>
    <dbReference type="OrthoDB" id="8694217at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00098">
        <property type="entry name" value="IgC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05768">
        <property type="entry name" value="IgC1_CH3_IgAGD_CH4_IgAEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000463">
        <property type="entry name" value="Immunoglobulin heavy constant gamma 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="114"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="320"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB76214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="468" mass="51013" checksum="082C258E6F3210FB" modified="2019-05-08" version="1">MMTVIAATPSPPTLYNLVSSCQQHNTNGSVTFGCLAMDYSPEITSLTWKKDGQLITTGVKKYPSVRNKKGTYTLSSQLTITESEGACSNISCEVRHSGSDKSIGMKCPRPVNTPNVLLTVSFRDKITRQKFATVVCSIIDFRPKSIAVKWLKNGQPMGSGIVTSPPCEVNGNFSVSSQLTVSAREWFSKAVYTCQVTHQEVTQSRHITASDPSLCTDASVTLLPPPIEQVLLEATVTLTCVISNAPYGVNVSWSEAKKPLKSEIAEQPGADTESVVSKLNISTQAWLSGAVFDCVVSHQDLPTPLRNSMRKKTDPNPREPSVSVLLPSAEDASAQRFVSLSCLVRGFSPREIFVKWTVNDKPVNPGNYKNTEVMAENGNSSFFMYSLLSIAAEEWASGASYSCVVGHEAIPLKIINRTVDKSSATTERIWTEDNEDDNGNIWTTASTFITLFFLSMSYSAAVTLVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTD6</accession>
    <name>A0A401PTD6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SERTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008796">
        <property type="protein sequence ID" value="GCB76362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTD6"/>
    <dbReference type="STRING" id="75743.A0A401PTD6"/>
    <dbReference type="OMA" id="TESPCKG"/>
    <dbReference type="OrthoDB" id="5976204at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029708">
        <property type="entry name" value="SERTAD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14272">
        <property type="entry name" value="SERTA DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14272:SF4">
        <property type="entry name" value="SERTA DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06031">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="1">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="350" mass="39110" checksum="0B7B6E6D7E4FAE7B" modified="2019-05-08" version="1">MTLVISMSRLCDLPTEGPSDIPEYVPVWEESFSKTTASSHQTKYGEPTESPCKGISNLLTTSKIAYFKRKYVEDGDLHPPAHTCCQRARTLAVPEDRTHILRLSLEKLRFIEDPEVFLRRSVLINNLLKRIRGEMQNDWYLSACSFGETPPNDWFGTQELTYRKRLRIAKEYENSLHDCCFYQDCGNQYSVIPFSVYNGDGAPSSLPSCSRQGMDCSEVYGAHNAHPRNDVATSVVSDIYENIGKLYDKEINEEDEHQKGSSAAKHTSSDRPLPLVCSDKGVDCSATGFRNDGMVPPESPLDSAILKQHVGDRKLCSVKEAKFESACFVMAGASNLTSIAKSTCRVSDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTR3</accession>
    <name>A0A401PTR3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0018350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012695">
        <property type="protein sequence ID" value="GCB76520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTR3"/>
    <dbReference type="STRING" id="75743.A0A401PTR3"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF497">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="216" mass="23871" checksum="92623AF32987E810" modified="2019-05-08" version="1">MPRYCLFGDTVNTASRMESTSLPQKIHISSVTFAALVQDDAYEIELRGETELKGRGKMKTYWLIGNKNYSVQNDSLVCHWNPRIKKKNENGDSMSSVQQSGGSSLVQTPSNRTTPLSIMEISANGHAGAKSLQKADSQLALSSLQSSEHSQPHSPNSENGVALHSRNPDQEQELYLKGTSSVESEPFTTKPDVTHIDHENRHLEKSELLPGFVNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTX2</accession>
    <name>A0A401PTX2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0019906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015304">
        <property type="protein sequence ID" value="GCB76574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTX2"/>
    <dbReference type="STRING" id="75743.A0A401PTX2"/>
    <dbReference type="OMA" id="TCETRII"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003836">
        <property type="term" value="F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051757">
        <property type="entry name" value="Beta-gal_alpha2-3_sialyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46032">
        <property type="entry name" value="ALPHA-2,3-SIALYLTRANSFERASE ST3GAL I ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46032:SF2">
        <property type="entry name" value="GAL BETA 1,3-GALNAC ALPHA-2,3-SIALYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB76574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8787" checksum="7339FD19FC130C13" modified="2019-05-08" version="1" fragment="single">MYRRVKSYIKADRDKLSVFGYGVDKDGNWHHYWENNRLAGAFHITGVHNATCETRIISHLAEIGKIQLYRGRHGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVU8</accession>
    <name>A0A401PVU8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0020556</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="12"/>
    <dbReference type="EMBL" id="BFAA01016774">
        <property type="protein sequence ID" value="GCB77256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVU8"/>
    <dbReference type="STRING" id="75743.A0A401PVU8"/>
    <dbReference type="OMA" id="IHLDLRC"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000009">
        <property type="entry name" value="mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="153"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB77256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="644" mass="74995" checksum="C9DB7994CC2C82E8" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVX5</accession>
    <name>A0A401PVX5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0019253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014129">
        <property type="protein sequence ID" value="GCB77213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVX5"/>
    <dbReference type="STRING" id="75743.A0A401PVX5"/>
    <dbReference type="OMA" id="PCSNIAL"/>
    <dbReference type="OrthoDB" id="9946382at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF5">
        <property type="entry name" value="INTERFERON GAMMA RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon/interleukin receptor" evidence="4">
        <location>
            <begin position="131"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB77213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40064" checksum="54CF5385C1A18C8B" modified="2019-05-08" version="1">MMDTAMSPEDDSAKEEGEPCQPSIDASYQLPRPVNVSLVSHNFKTVLTWAYVNETPEKANFTVHFTDYLTGQWQLYPPCSNIALHHCDVTKAFSVNLTASNSYYTKIKAITQLHQSQFTFTKRFSFKQNATIGAPTVEVKIRGQQIFLRCIYPIVQNLTTETGQKVGRDFRCNICVWQKGHNESRKKSCPNKKSKLKLNITQSRVTLCVSAQVNSKQWEMKAEWSTQKCFQVQSLNLQETLIILLVVIAFFLGLVTASIIWKLLKKELVLPKSLMLIVKTINPYADMKIEEDAVSIVIKYEEVIPVECDHFFEEAAKPITDPEVTESLTVDLKYAGKDWTYDRPQTLFNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWZ7</accession>
    <name>A0A401PWZ7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016861">
        <property type="protein sequence ID" value="GCB77628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWZ7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="136" mass="14971" checksum="A5B884FA69ACE9CC" modified="2019-05-08" version="1" fragment="single">IPHNSPFKLSLLLIPLLILLLFLLVSFIIFRKKRGHSWLIGCTRSSERKDCGLASTAGTDPAHQQSAPEQGDSCTYAEIDRRTGDKRFTINAPEDPQPDSCTYASVVIGSNREDQGGKRLRVADSEENVIYAAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ07</accession>
    <name>A0A401PZ07_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015741">
        <property type="protein sequence ID" value="GCB78387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ07"/>
    <dbReference type="STRING" id="75743.A0A401PZ07"/>
    <dbReference type="OMA" id="MHEGRRE"/>
    <dbReference type="OrthoDB" id="2570713at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="66788" checksum="3B3A81D5D91D8106" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ50</accession>
    <name>A0A401PZ50_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013106">
        <property type="protein sequence ID" value="GCB78398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ50"/>
    <dbReference type="STRING" id="75743.A0A401PZ50"/>
    <dbReference type="OMA" id="TSEREHW"/>
    <dbReference type="OrthoDB" id="199041at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14647" checksum="C4A3003107185CB8" modified="2019-05-08" version="1" fragment="single">GIDEWQDTGFRYDMISCLNLLDRCDRPLSLLKDIRNALEPSKGRLILAMVLPFQPYVENGGKWERPSEYLEVTGETWEEQVASFSNDVFSKVGFAIESFTRLPYLCEGDLHNDHYVLDDVVFILKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZB6</accession>
    <name>A0A401PZB6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018376">
        <property type="protein sequence ID" value="GCB78499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZB6"/>
    <dbReference type="STRING" id="75743.A0A401PZB6"/>
    <dbReference type="OrthoDB" id="6107607at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="6422" checksum="EA8CAA1007B1405C" modified="2019-05-08" version="1" fragment="single">MEWFTVYEHYRRAQCSVSELVVGNEYFFRVFTENMCGLSDEACQSKDSVYIQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1R9</accession>
    <name>A0A401Q1R9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0016938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010625">
        <property type="protein sequence ID" value="GCB79306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1R9"/>
    <dbReference type="STRING" id="75743.A0A401Q1R9"/>
    <dbReference type="OMA" id="RRPYCIK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21977">
        <property type="entry name" value="HMG-box_BHMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47658">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47658:SF1">
        <property type="entry name" value="MEIOSIS INITIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="478"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="478"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB79306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="564" mass="64478" checksum="9196C83F8CA40799" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q238</accession>
    <name>A0A401Q238_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016013">
        <property type="protein sequence ID" value="GCB79452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q238"/>
    <dbReference type="STRING" id="75743.A0A401Q238"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF449">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB79452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20567" checksum="B77E073BD013505B" modified="2019-05-08" version="1" fragment="single">MNSIAILVNGQWQNQSGTLPVQDIISNTSDLLGNDSLWENMEKEQRLLSASILLQSMKDLVIATGLNLPDQGKKNSTSKNIGGVWDYCRISALLFPGSIFLDVSGGSTALQHDQKHQEFEMYPDGYGSHTNCWLDAKTGLVWSFLGPVYLIIAVNTVLFFTFLWILKREVAKRDTQVSKLNDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q2L5</accession>
    <name>A0A401Q2L5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014719">
        <property type="protein sequence ID" value="GCB79669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q2L5"/>
    <dbReference type="STRING" id="75743.A0A401Q2L5"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF15">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="12724" checksum="3A136B8E5ED81253" modified="2019-05-08" version="1" fragment="single">TQKSWIEDVFYKRECGKIITSSKDSHRCLPGCQICQNLVRCCCGRLVGDHPGLDSKLPIYLSARDDGQEEWCVQKHTIASPTDAYGTVDFQDGAYSYRAKLRKSLSNSNFGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4Q2</accession>
    <name>A0A401Q4Q2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IF rod domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0018083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012282">
        <property type="protein sequence ID" value="GCB80348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4Q2"/>
    <dbReference type="STRING" id="75743.A0A401Q4Q2"/>
    <dbReference type="OMA" id="FRDWSIY"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF344">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="64"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB80348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="412" mass="46655" checksum="EE4DA20ACC1E4CAC" modified="2019-05-08" version="1">MTYRGYTSLSSHGGSMSMRRSMPLQSSASSISGYGQRMTVSRMSRVANLGSSAAGIGMGGVGSQKETMQDLNDRLATYLEKVRSLETGNAKLELQIKEHLDARGPSFRDWSIYEKPLNELRKEVYDMTVDNARFILQIDNARLAADDFRVKWESELTIRQSVENDINGLRKVIDDTNIGRLHLETEIESLKEELIYIRKNHEEEVRALRSQVADSSVHVEVDSTPGPDLSKVLAEIRKEYEGVAQKNKDDAESWYKNQMDSYKVEVKHNTDELRSAKLQVTELHRQIQSLEVELESLLSMKNSLEGSLRDTELRSEMELQTINGMIAKLEGDLLQIRGDMQSQVREYEILLNIKMKLEAEIATYRRLLDGEDINTLVESTSGVTSQTIKKTIVTTQKVVDGKIVSDETVQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4Z2</accession>
    <name>A0A401Q4Z2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009653">
        <property type="protein sequence ID" value="GCB80444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4Z2"/>
    <dbReference type="STRING" id="75743.A0A401Q4Z2"/>
    <dbReference type="OMA" id="SHMALQL"/>
    <dbReference type="OrthoDB" id="8788044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031510">
        <property type="entry name" value="DLEU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36961">
        <property type="entry name" value="LEUKEMIA-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36961:SF1">
        <property type="entry name" value="LEUKEMIA-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15760">
        <property type="entry name" value="DLEU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="173" mass="19487" checksum="F38FF90C583C384D" modified="2019-05-08" version="1">MHRALQVCIAHQQSALAILHQYLQDQRHLGPEPPSPGQTTRNRFKAACSTREPAPSSTSSRRRTLLQVARESKLTRLIGLTSELLYLEQNSLSQLQEPHFQLDCKLSAELRNLCNRMATRADCLQLDADLKAIERCLIDIVHQLTISLSSTSSESHPHAVDVLKRLSNKFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q640</accession>
    <name>A0A401Q640_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0022084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021137">
        <property type="protein sequence ID" value="GCB80854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q640"/>
    <dbReference type="STRING" id="75743.A0A401Q640"/>
    <dbReference type="OMA" id="FRAANIC"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000043">
        <property type="entry name" value="UDP-N-acetylhexosamine pyrophosphorylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF6">
        <property type="entry name" value="UDP-N-ACETYLHEXOSAMINE PYROPHOSPHORYLASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB80854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42613" checksum="048B81B486779612" modified="2019-05-08" version="1" fragment="single">PSPRSERPLSQFWNKTPRCFHEISENHVAVLLLAGGQGTRLGVQYPKGMYDVGLPSAKTLYQIQAERICKVQQLAEQKLGKKCTVPWYIMTSEFTLEPTQKFFTLHNYFGLVKSNVVMFEQQMLPAVDFNGKIILEQKGKIAMAPDGNGGLYRALTNNKILEDMDRRGIRFVHVYCVDNILVKMADPAFIGFCVEKGADCGAKVVEKAYPTEPVGVVCCVDGINQVVEYSEVSQATVEQRNADGRLTFNAGNICNHFFTVDFLKSVTEEFEPQLKCHVAVKKIPHVDEKGNPVKPEAPNGIKMEKFVFDVFQFSKKFVVFEVLREEEFSPLKNAENAGNKDTPSSARRALLWQHYRWAVQAGAHFLDQKGNRISPLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q653</accession>
    <name>A0A401Q653_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021133">
        <property type="protein sequence ID" value="GCB80848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q653"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="33" mass="3743" checksum="1CB65E3E3886A265" modified="2019-05-08" version="1" fragment="single">DGNRADDTKDEVAVESYVVQRYIENPYLIGESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6H6</accession>
    <name>A0A401Q6H6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01026417">
        <property type="protein sequence ID" value="GCB80985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6H6"/>
    <dbReference type="STRING" id="75743.A0A401Q6H6"/>
    <dbReference type="OMA" id="CIANIKP"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="134" mass="14080" checksum="49A79344221E1002" modified="2019-05-08" version="1" fragment="single">CGHCQNLAPEWKKAAFALKGIVKVGAVDADKHQSLGGQYGVQGFPTIKLFGINKNKPDDYNGARSAQGITDAALNSLRSIVQDRLGGKGGSSSSGKKSSGSGSGQKDVIELTDDTFDENVIGSSDIWMVEFYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q985</accession>
    <name>A0A401Q985_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021817">
        <property type="protein sequence ID" value="GCB81942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q985"/>
    <dbReference type="OMA" id="KGMNDPI"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="204" mass="21934" checksum="E211611A2AD85260" modified="2019-05-08" version="1" fragment="single">SDDAEEFQKQGLSHSKHPPPLELTSDSDSETEIEESAGGRGNEGGGLINTCVYEEEEDPESKPCTPSSACISISIKPKLRTRTREKMDSSLGVETPQDKPSGTEPGKGMNDPICKEPEEDMNGPISTEPGKGMNDPICKEPEEDMNGPISTEPGKGMNDPIGTEPGKGMNDPICTEPGKGMNDPIGTEPGDLEEQDERKETVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QA07</accession>
    <name>A0A401QA07_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023266">
        <property type="protein sequence ID" value="GCB82157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QA07"/>
    <dbReference type="STRING" id="75743.A0A401QA07"/>
    <dbReference type="OMA" id="CKYSARW"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="55" mass="6487" checksum="1A946FB654035FEB" modified="2019-05-08" version="1" fragment="single">SQLNSDLRHFLKQVFSKGSADFELQDRIRQNLYIRVVPYPRLSSISDMEHVLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAU1</accession>
    <name>A0A401QAU1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019497">
        <property type="protein sequence ID" value="GCB82499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAU1"/>
    <dbReference type="STRING" id="75743.A0A401QAU1"/>
    <dbReference type="OrthoDB" id="9421762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033182">
        <property type="entry name" value="MIC26/MIC27_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14564">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019106374" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8130" checksum="5A0C5E6695E1C205" modified="2019-05-08" version="1" fragment="single">VVQLAVSRTSLALLSVPVFAQSVKPEKGLLKIDQLSLYTTPAENYRFVEAEPSLLEERISGLRKLVGPYTTGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCH1</accession>
    <name>A0A401QCH1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Attractin/MKLN-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030310">
        <property type="protein sequence ID" value="GCB83071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCH1"/>
    <dbReference type="STRING" id="75743.A0A401QCH1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="3">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13486" checksum="0E56D32CA2F06F19" modified="2019-05-08" version="1" fragment="single">FDLNDVLGDLIRYNFTSNQWHRSSLSPSPAGRHSHTVVEWKGRMLLFGGQLANGSLANDIWLYDPLAESWKLLSAANSQCPPGLAAHTATVVEQYLYVHGGECVWGEIGLISEVWMCRIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCI4</accession>
    <name>A0A401QCI4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARMET C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01034176">
        <property type="protein sequence ID" value="GCB83052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCI4"/>
    <dbReference type="STRING" id="75743.A0A401QCI4"/>
    <dbReference type="OMA" id="TIEKEXK"/>
    <dbReference type="OrthoDB" id="5597848at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000003">
        <property type="entry name" value="Mesencephalic astrocyte-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045333">
        <property type="entry name" value="ARMET-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990">
        <property type="entry name" value="ARMET-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990:SF10">
        <property type="entry name" value="MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019117610" description="ARMET C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET C-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="115" mass="12898" checksum="79D62D25D53B0EF7" modified="2019-05-08" version="1">MLLASGVAAAFVFLVAPSGALKEGECEVCLSFLERFYNSLTEQEDRQSDCDLKYDKQVDLSTVDLKKLRVKELKKILEEWGESCKGCAEESDFIRKITDLVPKYAPLAAKSRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCI8</accession>
    <name>A0A401QCI8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01038116">
        <property type="protein sequence ID" value="GCB83094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCI8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="61" mass="7157" checksum="F516F2EB0653B2AE" modified="2019-05-08" version="1" fragment="single">KCFELEKNDKVQNVTESMQMPTIEYKDILIKDYSKYLHIQIIDNMNGAAHQHHINPGNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCY9</accession>
    <name>A0A401QCY9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain hydrolytic ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01033240">
        <property type="protein sequence ID" value="GCB83233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCY9"/>
    <dbReference type="STRING" id="75743.A0A401QCY9"/>
    <dbReference type="OMA" id="WNVIPAN"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF66">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16632" checksum="7813555AC5080334" modified="2019-05-08" version="1" fragment="single">TPDRKWLIFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSPQMSLIFEPMDLEVASPATVSRCGMVYMEPLMMGWKPVMVSWMNKMPPGVRPMHKELIEGLFDRMVPACLQFVRKAAKVTSWLSVFRFKWNVIPANMLTHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD90</accession>
    <name>A0A401QD90_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0023453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029507">
        <property type="protein sequence ID" value="GCB83326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD90"/>
    <dbReference type="OrthoDB" id="10618657at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="323" mass="34890" checksum="CDAA360D6B0038CA" modified="2019-05-08" version="1">MSVIDKTKTRRGVIGKTLTHVAVIDKTVTHLGVIDKTLTYLCVIDKTVTHIGVIEKIVTNLGAIVKTVTHLDVIGKTVTHLGVIDKTVTDFGVIDKIVTHLGVIDKRLTHLGVIDNALTNLGVFDKTFTHLGVIDKTVTHLGVIYTIVIHLGAIVQTVTHLDVIGKTVTHLGVIDKTVTDFGVIDKIIVTHLGVIDKTVTHLGVIDMALTHLGVIEKIVTNLGVNDKTITHLDVIDTIVIHLGAIVKTVTHLDVIGKTVTHLGVIDKTVTDFGVIDKIVTHLGVIDKRLTHLGVIDNALTHLGVFDKTLTHFGVIDKIVMHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDA4</accession>
    <name>A0A401QDA4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0023457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01029534">
        <property type="protein sequence ID" value="GCB83344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDA4"/>
    <dbReference type="STRING" id="75743.A0A401QDA4"/>
    <dbReference type="OMA" id="DGVHTYD"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF60">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="45"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB83344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="380" mass="41592" checksum="8AF46F13191EB79F" modified="2019-05-08" version="1">MAALRCLSRLLPVARSPLAQGLAGNRRSYSKGQQPFGKMYGGRITVTLIPGDGIGPELMQHVAHVFQATHVPVEFEEVRVDSSASDSRDINAAIEAIRRNRVALKGNFETAVDLIAKHRRSLNVFFRTELDLFASVNHYRSLQGVASRAGPLDIVVVRETTEGEYAHLEHESVHGVVESLKIITRKRSIRLAEFAFNYARRHGRSRLVVVHKANIMKLADGLFMQCCREVAAGYPEIEFSDVIVDNATMQLVSRPSQYDVMVTPSLYGVVINNICAGLVGGPGLVPGASYSHDCAVFQTAIRNTAPRLAKRNVANPTAMLLAGCLMLDHLQLSTHATIIRDAIIKAVTDAKIHTADIGGRASSTDMVDYIIDRIAKVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QED4</accession>
    <name>A0A401QED4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0024245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01041926">
        <property type="protein sequence ID" value="GCB83745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QED4"/>
    <dbReference type="STRING" id="75743.A0A401QED4"/>
    <dbReference type="OrthoDB" id="387093at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB83745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="9137" checksum="878F3C5020429FF5" modified="2019-05-08" version="1" fragment="single">RQCGCCWAFGVVANIESMWFIKTKQLLELSEQELVDCDTLDLACKGGYPYNAFNSIIKLGKETSPRKEMDRVGEGGLAFAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH94</accession>
    <name>A0A401QH94_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01095258">
        <property type="protein sequence ID" value="GCB84745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH94"/>
    <dbReference type="STRING" id="75743.A0A401QH94"/>
    <dbReference type="OMA" id="DIMRHIG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="131" mass="14531" checksum="66E0AF167BE0A0FB" modified="2019-05-08" version="1" fragment="single">LRVSTGEHDEELRVSAGEHDEELRVSAGEHDEELIVSAGGHDELRVSASEHDEEIRVSAGEHDEEIRVSAGERYELRVSAGEHDEELRVSAGEHDEELRVSAGEHEQLRVSVGEHDEELRVSAGEHDELPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHK1</accession>
    <name>A0A401QHK1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0025406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:60004"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01092170">
        <property type="protein sequence ID" value="GCB84813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHK1"/>
    <dbReference type="STRING" id="75743.A0A401QHK1"/>
    <dbReference type="OMA" id="NEANAHN"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF45">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE NNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="7">
        <location>
            <begin position="121"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB84813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="268" mass="31233" checksum="1D6A40364ED85E70" modified="2019-05-08" version="1" fragment="single">MVMVDGLGGSYEYELTLRTDLYTDKHTQWYYFRVQNTRPGVTYRFTIVNLMKSNSLYNQGLKPLLYSEREAQQRQMGWHRVGKDIRYYKNNLSEEGRSLYSLTWTFQFPHRNDTCYFAHSYPYTYSDLQRYLATIANDPIQSQYCKLRVLCRSLAGNTVHILTITSPSRNQESGPTKKAVVVTARVHPGETNGSWVMTGFLDHILGNSDDAQLLRDMFIFKVVPMLNPDGVITGNYRCSLTGRDLNRNYRTLLRDSFPCVWHTRNMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI27</accession>
    <name>A0A401QI27_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01117197">
        <property type="protein sequence ID" value="GCB85010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI27"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="146" mass="16268" checksum="A36E5A745F203565" modified="2019-05-08" version="1">MSLSKYHYRRVAVGASLSKCHYRSITVEVAMAKSHSRCVAVKVSQLKSRCRGVAVEVSLSMCRCLGFSVKCQCRSAAVEVSLSRFQCEVSMSKCRCRSVAIKVSLPMYHCRGIMIDVSLLKYRCRNVTSEVSLSKCHCRCVALEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLD5</accession>
    <name>A0A401QLD5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01239280">
        <property type="protein sequence ID" value="GCB86133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLD5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031372">
        <property type="entry name" value="CAMSAP_CC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17095">
        <property type="entry name" value="CAMSAP_CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="245" mass="26061" checksum="D19134D20AE92908" modified="2019-05-08" version="1">MTSFVERKQLKARGRRWSRAGGHPAEAQQDPGGWEGQSRGGSSPEAFQLRKLLEEKRREIRAQIRAMEALSARQWQTLGRRAFRGLMREQEVGAEGQAAAGNGAGCEEGGGPGRGPVPSEASNYHSTMGKLSGSLIAVQDELEHLAVREPPRPDLEHNQGPEQREIGDPSAGRLRGAGGGPGRASQSPCGRHSDRLEAGTPAGRHPPGTDTGGAQEPEETSGNVGERNPPENHAGAAEQSQVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLI5</accession>
    <name>A0A401QLI5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01266385">
        <property type="protein sequence ID" value="GCB86245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLI5"/>
    <dbReference type="STRING" id="75743.A0A401QLI5"/>
    <dbReference type="OMA" id="KLKYVRH"/>
    <dbReference type="OrthoDB" id="28829at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF16">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="79" mass="8699" checksum="F63AA9D3E9B8480E" modified="2019-05-08" version="1">MGSVGGLGGDYMKESVLALEHVSTEQIQEVEEDLDLLYDSLELYNPSDSGPEMEETESVLSTPKPKLKYVRHLEAAPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLR6</accession>
    <name>A0A401QLR6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT LRR and PYD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0026941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Inflammasome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01261314">
        <property type="protein sequence ID" value="GCB86253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLR6"/>
    <dbReference type="STRING" id="75743.A0A401QLR6"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1271">Inflammasome</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="NACHT LRR and PYD" evidence="7">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB86253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="20336" checksum="3ABF02AB955BAEA5" modified="2019-05-08" version="1" fragment="single">SVVYTFPHLTIQEFVAALAQFLTPDPGDIGKLLSEAHIKGDGRFEIFLRFVAGLSSPQAARPLETFLGQFLHQTTCRVIDWVKEKVEGQIGNTESESGKRNPLNTFHYLFESQNKALAQKTVGSVEIITFSELRLTPIDCAVLSHVIGLCDTIKHLDLVGCYIQCEGLQRLEPVLHKCKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMR8</accession>
    <name>A0A401QMR8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01313562">
        <property type="protein sequence ID" value="GCB86603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMR8"/>
    <dbReference type="OrthoDB" id="5870064at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="269" mass="30865" checksum="E802FD54E063A314" modified="2019-05-08" version="1" fragment="single">LPHLAPQALVLRYLAPRALELRYLAPWAPELPYLAPRAPELPYLAPRALELPYLDLRAPELLYLAPRALVLPYLAPRALELPYLDPQALVLPYLAPRALELPYLAPRALELPYLAPRALVLLYLAPQAPELPYQAPRAPELPYLAPWAVELSYLNPRAVKQAYLAPRAPDLPYLAPWALVLLYLDPQALVLPYLAPWALVLPYLAPWALVLPYLAPGPRYCLTWLLGLRYCITWLPGLWYCFTWIPRLWYCLTWLPGLWYCLTWLPGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI66</accession>
    <name>A0A401NI66_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pleckstrin homology-like domain family A member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Imprinted in placenta and liver protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0011156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PHLDA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004980">
        <property type="protein sequence ID" value="GCB60572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NI66"/>
    <dbReference type="STRING" id="75743.A0A401NI66"/>
    <dbReference type="OMA" id="CMERTGK"/>
    <dbReference type="OrthoDB" id="9630709at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042832">
        <property type="entry name" value="PHLA1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478:SF8">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB60572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19367" checksum="2F450AEEBAC9E674" modified="2019-05-08" version="1" fragment="single">YFLSVSAPAAGSSNLSPRAGSFFSQPRLEEEVARMKKITDGAQVIKEGVLEKRGDNLLQLWKKKYCVLTRDSVGLFPDCQTRSRRKELSLQQIRTVDCVERTGKYIYFTVVTTDNKEMDFRCLGESCWNSAITMALIEFKNRKAIQTFKSRQESETPSPDQQEKVLGRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIX0</accession>
    <name>A0A401NIX0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005011">
        <property type="protein sequence ID" value="GCB60818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIX0"/>
    <dbReference type="STRING" id="75743.A0A401NIX0"/>
    <dbReference type="OMA" id="VKDIMMC"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="431"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="795"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="917" mass="101302" checksum="4C3C65F0CF927E7A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJR9</accession>
    <name>A0A401NJR9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0011262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005057">
        <property type="protein sequence ID" value="GCB61151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJR9"/>
    <dbReference type="STRING" id="75743.A0A401NJR9"/>
    <dbReference type="OMA" id="QEERWRV"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16475">
        <property type="entry name" value="RING-H2_RNF121-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000074">
        <property type="entry name" value="Ring finger protein 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF1">
        <property type="entry name" value="E3 UBIQUITIN LIGASE RNF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB61151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="246" mass="28592" checksum="654A6036B3FFD28C" modified="2019-05-08" version="1" fragment="single">LVTLFQMWVVPLYFTAKLHWWRFLVIWVLFSIITAFITFRATRKPLEGTTPRLVYKWFLLLYKLSYASGIVGYAGVMFTLFGINLLFRIKPEDGMDFGVSLLFYGLYYGVLSRDFAEMCADYMASTIGYYSASGMPTKHLSNEICAVCGQKIFVDVNEEGIIENTYMLTCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGINYSLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJS7</accession>
    <name>A0A401NJS7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil alpha-helical rod protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-helical coiled-coil rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0014278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a regulator of keratinocyte proliferation or differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007603">
        <property type="protein sequence ID" value="GCB61097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJS7"/>
    <dbReference type="STRING" id="75743.A0A401NJS7"/>
    <dbReference type="OrthoDB" id="193258at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009800">
        <property type="entry name" value="HCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46822">
        <property type="entry name" value="COILED-COIL ALPHA-HELICAL ROD PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46822:SF1">
        <property type="entry name" value="COILED-COIL ALPHA-HELICAL ROD PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07111">
        <property type="entry name" value="HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB61097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="13107" checksum="A6FA1B588E0F6B23" modified="2019-05-08" version="1">MQTSGKLQEEQHQRELQRLGNKLRELERDKNLLVATLRQEGLLSQYKKSRAAAIHSSAALREDEELARPLPHSQASKAGGQAYNKGSLAEVLDELQALSAAVIGDQEEADTNREEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKH2</accession>
    <name>A0A401NKH2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003782">
        <property type="protein sequence ID" value="GCB61373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKH2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="6788" checksum="11A0B652F5841ED1" modified="2019-05-08" version="1">MPARGEGVSNSNGAERARGVVGRSRVATAARGPGHSDERAERPRSRDRVAVPAVTSAAPAAPVEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKJ5</accession>
    <name>A0A401NKJ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0014330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007646">
        <property type="protein sequence ID" value="GCB61406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKJ5"/>
    <dbReference type="STRING" id="75743.A0A401NKJ5"/>
    <dbReference type="OMA" id="HERECTM"/>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015108">
        <property type="term" value="F:chloride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF89">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0868">Chloride</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB61406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="21672" checksum="7045B8C661F845A7" modified="2019-05-08" version="1">MERQVKVLHLREKVSSLAALLLETNHGGFPVIYQLEQAHEEVFIGSITRLELCRILENEMLFETQNEGTYKQHAELNYNEISVKFLNSTKINLLLNKYRTDNQYKDYYVNLKPYINQSAMTVHAHFSLQRTYIIFRTLGLRHLTVVDLRNHVLGIITRKDLMAFRLEEKLLQSENLESYNDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKU5</accession>
    <name>A0A401NKU5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005097">
        <property type="protein sequence ID" value="GCB61485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKU5"/>
    <dbReference type="STRING" id="75743.A0A401NKU5"/>
    <dbReference type="OMA" id="ENNNRAD"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10497">
        <property type="entry name" value="MH2_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="10">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="11">
        <location>
            <begin position="271"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB61485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="465" mass="52201" checksum="1B2F46D6A965FFC3" modified="2019-05-08" version="1">MTMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGHNDPPMPQNAAFPVSFQQPNTHPFPNSPNRSYPSSPGSSTYPHSPASSGPSSPFQMPADTPPPAYMPPDDQMTQDSSQPMDTSNVLVPTIPPNIINRADVQPVAYEEPKHWCSIVYYELNNRVGEAFQASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNA7</accession>
    <name>A0A401NNA7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA 2-O ribose methyltransferase substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0007213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002568">
        <property type="protein sequence ID" value="GCB62334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNA7"/>
    <dbReference type="STRING" id="75743.A0A401NNA7"/>
    <dbReference type="OMA" id="FLKFHKY"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18106">
        <property type="entry name" value="SpoU-like_RNMTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053888">
        <property type="entry name" value="MRM3-like_sub_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22435">
        <property type="entry name" value="MRM3-like_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="6">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB62334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="349" mass="38778" checksum="8352D8F39368462A" modified="2019-05-08" version="1">MAALRGNVSRWAVVLTPGRRHVRTLRRRPLEVLKVVTIAKSKKFRDQQGKILVEGRRLIIDALGAGALLQTLFFSTVDSLKELPLEKLKHVKLIKVKFEEIKMWSDLVTPQGAMGIFVRPDHSKMKYPSVQQEHTIPLSLIGDNIRDPGNLGTILRSAVAAGCSKVLLTKGCVDVWEPKVLRAGMGAHFRIPVISNLEWDVVPNYLATSTRVHVADHSHWSAGKSVVPRKSHAAGDQSWASHTRQTEEQEGGTEDREREFLLSLPEVEARCYHRTWAEGQTAIVIGGETQGLSLEALLLAQKMRGQRLYIPMIPGVDSLNSAMAASILLFEGRRQLLSSVANGNRTERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNK9</accession>
    <name>A0A401NNK9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01006535">
        <property type="protein sequence ID" value="GCB62460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNK9"/>
    <dbReference type="STRING" id="75743.A0A401NNK9"/>
    <dbReference type="OMA" id="NTIRWLR"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB62460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="335" mass="37280" checksum="F6F857F257418F78" modified="2019-05-08" version="1" fragment="single">NRNLKTLLSIGGWNFGTQKFSTMVSKSENRQIFIKSVIRLLRGYGFDDLFSHRYLDFFNVMTYDFVGSGNIVTGENSPLYPLPNNKHYTNLYFNVNFTMNYWRIQGAPAEKLNIGFPTYGHTFRLTTSDHGIGAPSGGPGPAGKYTRSTGSLAYYEICTLLKSGTSIWNAPQVVPYGYKGDTWIGYDNVKSFRDKAEWLTKNNFGGAMVWTLAMDDFSGSFCNQGPYPLINALHTGLGISSACVPSKTTLKPAVPVTQPPGSGFCANKSNGFYADPKDKTKFYQCDDGVTYLKNCIPGSRQEQTFETLTQTRSTAPQYLQSFRHLTGKHRESGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP15</accession>
    <name>A0A401NP15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0004276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001257">
        <property type="protein sequence ID" value="GCB62620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP15"/>
    <dbReference type="STRING" id="75743.A0A401NP15"/>
    <dbReference type="OMA" id="FHHEYEK"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="230"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="448" mass="50290" checksum="CAD27BE69341DB46" modified="2019-05-08" version="1">MDQEYERRLLRQTHFQNVSENMLSLSALSTRPVTSNSPATVPRKTGDRFIPTRASSNWSINFHTINENGKSPNQNRKTKEANSDNGKDGVAYAALLKNELLGAGIEKVSDPQTEDRRFQMPMQERRNLFRYALSTKRSTTESGNEISPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSAINVLSVGLGACVYLWSACTSQVTRLCDLSIDGALAWNADQLSSGSRDRLILQRDVRTPPLQMERRLQGHRQEVCGLKWSPDHQHLASGGNDNKLFVWNNSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTCQPLQCVDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAISPDGEAIVTGAGDETLRFWNVFSKTRSTKESKSVLNLFTRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPI2</accession>
    <name>A0A401NPI2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005258">
        <property type="protein sequence ID" value="GCB62752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPI2"/>
    <dbReference type="OrthoDB" id="9904304at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044609">
        <property type="term" value="C:DBIRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007071">
        <property type="entry name" value="AKAP95"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12190">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN AKAP 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12190:SF1">
        <property type="entry name" value="DBIRD COMPLEX SUBUNIT ZNF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04988">
        <property type="entry name" value="AKAP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB62752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="244" mass="27273" checksum="21ECC0B5318D6275" modified="2019-05-08" version="1">MHPLPSSSPRDIEMPACVAIGFRYGDPDLIISDSDVIIQPLPGGSPQWRSNRKYAEAGPTKSLKEQKVAVAEKARKAAVVKAQASGARIKTTKAQHIVTNSNKKLRITSKHLIIRKLSSSLERTWQFGKRAADSFHATIVNKNKKIADRKQQEQKESAQKHMKDVWMGVAPNNQMKRVGAAQSADCNTNIPFLFESVQQHLKSNEHINSKKNYHNLALVNNPTLKAKFDMFLKGENPFGNPQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPQ4</accession>
    <name>A0A401NPQ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006577">
        <property type="protein sequence ID" value="GCB62817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPQ4"/>
    <dbReference type="STRING" id="75743.A0A401NPQ4"/>
    <dbReference type="OMA" id="IYEHDDQ"/>
    <dbReference type="OrthoDB" id="6157531at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043299">
        <property type="entry name" value="LRATD1_LRATD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46341">
        <property type="entry name" value="PROTEIN FAM84B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46341:SF1">
        <property type="entry name" value="PROTEIN LRATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="2">
        <location>
            <begin position="115"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB62817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="271" mass="29955" checksum="0297CB5F33810D31" modified="2019-05-08" version="1">MGNQIDRITHLSYSELPTGDPSGIEKDELRVGVAYFFSDEEDEVDAERAPSERQWKEPVAGQDEAAATAVAGAGELEYSAFCRQECIFSKLGGSQDLTVYPVNSLLPSCRAGDLLELPAGGQPPHWAVYVGGSQVVHLHPGRREIRQEHLAEVGGGRLGARVVNTWYRYRALPPELVVQNARGHLGLAGRDICWSDSESFAAWCRFGKREFKAGGEAQGGGGRYFLKLHLSDNWVHTLNFASLEDLIREKRRKDASGKIRVLKELSVLNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPV0</accession>
    <name>A0A401NPV0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CREG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005277">
        <property type="protein sequence ID" value="GCB62894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPV0"/>
    <dbReference type="OMA" id="HASSWGC"/>
    <dbReference type="OrthoDB" id="9869319at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000004">
        <property type="entry name" value="Cellular repressor of E1A-stimulated genes 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF15">
        <property type="entry name" value="PROTEIN CREG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018995185" description="CREG-like beta-barrel domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="7">
        <location>
            <begin position="122"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB62894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="295" mass="32895" checksum="1E98908E3ACE07A4" modified="2019-05-08" version="1">MAVLSLFSLALLAWLAHRSRGYVIVNSVSWAVTNQEETVSAEEEEDNEGVDVLPNRLFASSSSIWKAEPYPAAAVYQEQVANGRAVAELPSPKEVPSFPSRMFSYRREGLGAKGPEQVPPEPPQQEKALTARRLLHSSNWGFLAILSSLDKIKGMPFGSIFSISDGLLDNSTGIPFFCVSPVDPTVSDLMNNPSASLTLSEAETDYCRQNLIDLEDSRCARLTLTGQVVTVPTDEIEFAKQAMFSRHPVMKKWPPDHNWFFMKMNIQHVWLQDWFGGVTIIPLEDYYKANPANVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQD7</accession>
    <name>A0A401NQD7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox protein engrailed-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0011566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Engrailed homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005296">
        <property type="protein sequence ID" value="GCB63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQD7"/>
    <dbReference type="STRING" id="75743.A0A401NQD7"/>
    <dbReference type="OMA" id="QTNRYIT"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000167">
        <property type="entry name" value="Homeobox protein engrailed-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000747">
        <property type="entry name" value="HD_engrailed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019549">
        <property type="entry name" value="Homeobox-engrailed_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019737">
        <property type="entry name" value="Homeobox-engrailed_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10525">
        <property type="entry name" value="Engrail_1_C_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00026">
        <property type="entry name" value="ENGRAILED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00033">
        <property type="entry name" value="ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU510713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB63074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="274" mass="30796" checksum="CBFE21C4BB36F1CF" modified="2019-05-08" version="1">MEEQKDQNNRVESRESSEAESVSLSPPFHSPQIQPHPAAQPPHRNTNFFIDNILRPDFGCKKDRDRAQTSGRENVNPLTRPLGASSVSPSLDCTDNSSQPSKQPQPKQNEGNGTNPAKYAENTGSALMLVGSNAEPKSNSDGNKSASAANLMWPAWVYCTRYSDRPSSGPRTRKLKKKKSEKEDKRPRTAFTAEQLQRLKAEFQTNRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKASGLKNSLALHLMAQGLYNHSTTTVQDEKEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRU7</accession>
    <name>A0A401NRU7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005361">
        <property type="protein sequence ID" value="GCB63579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRU7"/>
    <dbReference type="STRING" id="75743.A0A401NRU7"/>
    <dbReference type="OMA" id="RIVQKSC"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB63579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10495" checksum="CE13CD9D6AC1E8E1" modified="2019-05-08" version="1">MVATAQTRRTFVNSAISFLRQHRFDGLDLDWEYPGSRDSPPEDKHRFTLLIKDLKEGFEQEAESSGQNRLLVIAAVAAGKPSIDAGYEIAEVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRV6</accession>
    <name>A0A401NRV6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0011646</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005362">
        <property type="protein sequence ID" value="GCB63589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRV6"/>
    <dbReference type="STRING" id="75743.A0A401NRV6"/>
    <dbReference type="OMA" id="ICTEHAI"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB63589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="445" mass="49860" checksum="A21C0A1D22027541" modified="2019-05-08" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGNYNGDSDLQLNRINVYYNEASGGRYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGHSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGLGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEIEQDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRW1</accession>
    <name>A0A401NRW1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0011644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005362">
        <property type="protein sequence ID" value="GCB63587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRW1"/>
    <dbReference type="STRING" id="75743.A0A401NRW1"/>
    <dbReference type="OMA" id="AQQTWEG"/>
    <dbReference type="OrthoDB" id="9940651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB63587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22572" checksum="2F43F3C368D97540" modified="2019-05-08" version="1">MGSVVLELVALFLAVHGLICVILTCTLPLWKVPAFIGANIVTAQQTWEGLWMDCVWQGTGELVCNTFDSMLILGQELQVARALTTTAGVLGALGILVSVAGASWTKVVQSVPCKGRIVSAAAFLYLVTGIMQLIPVARYASSIVRDFRSTAVPDAVKRELGPSLYIGMTAGLLFIASSALLWSSCYTSRTQRTATHYTHGQANYDESHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRX2</accession>
    <name>A0A401NRX2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0009693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004032">
        <property type="protein sequence ID" value="GCB63648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRX2"/>
    <dbReference type="STRING" id="75743.A0A401NRX2"/>
    <dbReference type="OMA" id="MAMIDGR"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="4">
        <location>
            <begin position="49"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB63648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="157" mass="17723" checksum="B684C0D071A6C894" modified="2019-05-08" version="1">MGDMTNSAVDFYPKNQRGESNHAGEFGCSLDELRSLMELRGSEAVQKIQDTYGDMNGFCRRLKTSPTEGLAGNPADLENRRLIFGRNFIPPKKPKTFLQLIWEALQDVTLIILELAAIISLGLSFYQPPGERSESLCDCVNRAKWDMVEILYFKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRZ6</accession>
    <name>A0A401NRZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0007413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002683">
        <property type="protein sequence ID" value="GCB63629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRZ6"/>
    <dbReference type="STRING" id="75743.A0A401NRZ6"/>
    <dbReference type="OMA" id="FWDSSTA"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04145">
        <property type="entry name" value="M_R_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB63629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23527" checksum="5A640098C2AB1C55" modified="2019-05-08" version="1">MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDGQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKVTSEQGREMAAKYNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKAKWRGDRTAGSNKLQCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTU5</accession>
    <name>A0A401NTU5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myelin basic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Myelin membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the myelin basic protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000048">
        <property type="protein sequence ID" value="GCB64308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTU5"/>
    <dbReference type="STRING" id="75743.A0A401NTU5"/>
    <dbReference type="OMA" id="TTHKAHQ"/>
    <dbReference type="OrthoDB" id="8862162at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000548">
        <property type="entry name" value="Myelin_BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11429">
        <property type="entry name" value="MYELIN BASIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11429:SF0">
        <property type="entry name" value="MYELIN BASIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01669">
        <property type="entry name" value="Myelin_MBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00212">
        <property type="entry name" value="MYELINMBP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00569">
        <property type="entry name" value="MYELIN_MBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="349" mass="38207" checksum="458B060D3EFFECA6" modified="2019-05-08" version="1">MGNLSGKHDYHHSATDQSAKAVCEAETRSLTMDPPEDNEVFAEADVNQNNGSSSKPKKMVATGSKNVEDPKNAWKSPNTAEAAVRPHLVRLFSRDAPGREDNTFKDRPSESEDLQAIQEDSSVPVADSDLMEVQKLSSQSSAKKGQVAKQMASASASDHAKQAGGAHSRQRDSGLLDQLGKFFGQEGPRRVPEKGKEPARSVLMAPTTHKAHQGARRQTDDSAVVHFFKNMMSPKRAPAQQKKSNDRINISAVSSDRILTFKRGPEQVELSLNLSGVLMDKGHIMGHLVLPSQKKRIEDGKMAQELSHPFSKWGEKVKVHLRDVKSTSMSAAERNASKMKNIPLLGVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTZ1</accession>
    <name>A0A401NTZ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tripeptidyl-peptidase 2</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tripeptidyl aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tripeptidyl-peptidase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0004590</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01001365">
        <property type="protein sequence ID" value="GCB64358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTZ1"/>
    <dbReference type="STRING" id="75743.A0A401NTZ1"/>
    <dbReference type="OMA" id="XRICEVI"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04857">
        <property type="entry name" value="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.710:FF:000001">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3170:FF:000001">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000009">
        <property type="entry name" value="tripeptidyl-peptidase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034051">
        <property type="entry name" value="TPP_II_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022232">
        <property type="entry name" value="TPPII_C_art"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12583">
        <property type="entry name" value="TPPII_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="34"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="351"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="16">
        <location>
            <begin position="460"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="17">
        <location>
            <begin position="592"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="14">
        <location>
            <begin position="715"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II C-terminal" evidence="15">
        <location>
            <begin position="961"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="944"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB64358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134040" checksum="29D7B4D65020D69B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU01</accession>
    <name>A0A401NU01_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001366">
        <property type="protein sequence ID" value="GCB64373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU01"/>
    <dbReference type="STRING" id="75743.A0A401NU01"/>
    <dbReference type="OMA" id="DFPKCVE"/>
    <dbReference type="OrthoDB" id="10040207at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027886">
        <property type="entry name" value="SPMIP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31393">
        <property type="entry name" value="C5ORF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31393:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15093">
        <property type="entry name" value="SPMIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB64373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="585" mass="66895" checksum="9344D0E4EB5D4F3B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVD6</accession>
    <name>A0A401NVD6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Specifically androgen-regulated gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0007593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002790">
        <property type="protein sequence ID" value="GCB64835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVD6"/>
    <dbReference type="STRING" id="75743.A0A401NVD6"/>
    <dbReference type="OMA" id="HSEPQSW"/>
    <dbReference type="OrthoDB" id="9898538at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026152">
        <property type="entry name" value="SARG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21555">
        <property type="entry name" value="SPECIFICALLY ANDROGEN-REGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21555:SF1">
        <property type="entry name" value="SPECIFICALLY ANDROGEN-REGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15385">
        <property type="entry name" value="SARG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="59892" checksum="7FBCBB1B22A436AD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWE1</accession>
    <name>A0A401NWE1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0004725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001418">
        <property type="protein sequence ID" value="GCB65154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWE1"/>
    <dbReference type="STRING" id="75743.A0A401NWE1"/>
    <dbReference type="OMA" id="WNITYLL"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB65154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="273" mass="30147" checksum="FAF9BB01D84E0E41" modified="2019-05-08" version="1">MAGKVLETVGKFGLGLAIVGGVVNSALFNVDAGHRAVIFDRFRGVQNKVSGEGTHFLIPWVQRPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPMSDQLPRIYTTIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSEDLTERASAFGLVLDDVSLTHLTFGKEFTEAVELKQVAQQEAERARFVVEMAEQHKKAAVISAEGDSKAAELIANSLSKFGDGLIELRKLEAAEDIAFQLSRSRNVTYLPSGQSTLLQLPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWG1</accession>
    <name>A0A401NWG1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0400 (RTT103) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006854">
        <property type="protein sequence ID" value="GCB65216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWG1"/>
    <dbReference type="STRING" id="75743.A0A401NWG1"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032337">
        <property type="entry name" value="RPRD1A/B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16566">
        <property type="entry name" value="CREPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="331" mass="37638" checksum="1C7B3FFB082F114E" modified="2019-05-08" version="1">MLSMESRRVNCIQHVVVGEQTCQLYPAMLSMGRRRVNCIQHVVDGEQTCTITYQIAIELLTFLFQFLSTAKPSRKLTFLYLANDVIQNSKKKGPEFTKDFAPVLVDAFSHVSSESDENCKKHLERVLTIWQERMVYENNFIDQLKQIVSTEKKTKKRTFEQIQEEDDDDYLSNSTPKEPPETEDLIKSLQELENAASGDAAVRQKIASLPPEVQDVSLLDKIADKESADRLSKTVDEACMLLADYNGRLAAELEDRKQLARMLADYIRSQNEILAEKERKLEEYKHKLAKVTQVRKELKSHIQSLPDLSQLPNVTGGLAPLPSAGDLFSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWL5</accession>
    <name>A0A401NWL5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0004749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001426">
        <property type="protein sequence ID" value="GCB65263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWL5"/>
    <dbReference type="STRING" id="75743.A0A401NWL5"/>
    <dbReference type="OMA" id="RCKANDL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0558">Oxidation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB65263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="450" mass="50260" checksum="80372FDE5D560ADE" modified="2019-05-08" version="1">MKTGHPVEALGKRCHVRTPCKEERCKANDLCQYQALNTKTHEDAYLQPRIEEALQVLKDFLPHLPDGISSRLGTMGDEEIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVSIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLIKILTERGYSFTTTAEREIVRDVKEKLCYVALDFETEMVMAATSSTLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMETTGIHETTFNSIMKCDIDIRKDLYANTVLSGGSTMYPGIADRMQKEITALAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQMWITKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWY3</accession>
    <name>A0A401NWY3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecto-NOX disulfide-thiol exchanger 1/2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002839">
        <property type="protein sequence ID" value="GCB65383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWY3"/>
    <dbReference type="STRING" id="75743.A0A401NWY3"/>
    <dbReference type="OMA" id="QGMFQRM"/>
    <dbReference type="OrthoDB" id="10039782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056611">
        <property type="entry name" value="ENOX1/2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF6">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23267">
        <property type="entry name" value="ENOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ecto-NOX disulfide-thiol exchanger 1/2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="206" mass="23626" checksum="1A9BBD720F634412" modified="2019-05-08" version="1" fragment="single">LASQACALKEENDSLRWQLDAYRNEVELLKQEQGMFQRMDENHTKDQQLQFQQQAMQGMQQQLLTLQGEYRKKESELEKIKEENSHVQVLLSTLKEKEMNGFTLSVSTQGSQTSEGGPAARPLKSEKEALLVGIISTFLHVHPFGANIEYLWSYLQRLDAKISSGEIEMLLVQLPHMFKQEFTGVGATLEKRWKFCAFEGIKTISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXW2</accession>
    <name>A0A401NXW2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylserotonin O-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Hydroxyindole O-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0004842</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.4" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01001455">
        <property type="protein sequence ID" value="GCB65707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXW2"/>
    <dbReference type="STRING" id="75743.A0A401NXW2"/>
    <dbReference type="OMA" id="ADFSLHM"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017096">
        <property type="term" value="F:acetylserotonin O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030187">
        <property type="term" value="P:melatonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000358">
        <property type="entry name" value="Acetylserotonin O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0471">Melatonin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="11">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="10">
        <location>
            <begin position="119"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB65707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="306" mass="34669" checksum="E4A368CAA798B51A" modified="2019-05-08" version="1">MEVSKQELEYPQMLLNYMDGFMISKTMFAACELGVFDLLLEVGGPLSSNAIAERLGTSADGMDRLLAACVGLRLLEVKEHQGEVLYSNTDLSQMYLTKASPRTLYYSVAYYSHTIYHCFSHLTDAIREGKSQYERAFGISSMELFESLYRSEEEMLKFMQLMNSIWNICGKDVVTAFDLSTFTNIFDLGGCTGAIAKECISAYPRSRVTIYDLPKVVEMAGRYFVSPDEERITFHEGSGVLLIEALLEEDRRGPITTQLYSLNMLVQTEGKERMPSEYLKLLESAGFKDVQIRKTGKIYNVIFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY39</accession>
    <name>A0A401NY39_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Core shell protein Gag P30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008211">
        <property type="protein sequence ID" value="GCB65775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY39"/>
    <dbReference type="STRING" id="75743.A0A401NY39"/>
    <dbReference type="OrthoDB" id="9049599at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050462">
        <property type="entry name" value="Retroviral_Gag-Pol_poly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33166">
        <property type="entry name" value="GAG_P30 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core shell protein Gag P30" evidence="1">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="205" mass="23489" checksum="8CC57D17586E702B" modified="2019-05-08" version="1">MQAILGNLLTPDERQMVRQAGMRIWERENPAVGGVPAIQGEVKYPIARPPWDPQTPAGRQEMVDYRKLIVKGIRESVPKGQNVEKAFENRQEKDEAPAIFLQRLRRSIQQYSGMDPESDAGQQVLRANFVTKSWPDIKKKLEKLEDWNDKSMNELLKEAQEVYVRKKDEKTKGKAKLMMQVVSKLWKRSGIVKVETGEGEEAGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYT8</accession>
    <name>A0A401NYT8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000096">
        <property type="protein sequence ID" value="GCB66010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYT8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="97" mass="11418" checksum="82D46F5E7154F19C" modified="2019-05-08" version="1">MMMQRKLRINVRYVPGRVTCRRQEEEVVVVVEVAPGRARSWQREWQREQQRPERPDPRWAFSGCHVPLSEKGSDLSRSPDEFAGNLRALTDPHFCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZT0</accession>
    <name>A0A401NZT0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0014985</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008282">
        <property type="protein sequence ID" value="GCB66360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZT0"/>
    <dbReference type="STRING" id="75743.A0A401NZT0"/>
    <dbReference type="OMA" id="FVQMEST"/>
    <dbReference type="OrthoDB" id="1166527at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB66360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="126" mass="14030" checksum="2E112078AF4F63F8" modified="2019-05-08" version="1">MPEAAGKGIAPKKGPKKAATKKRVKGEKKRKKSRKESYSIYIYKVLKQVHPDTGISSSAMSVINSFVNDIFERIACESSRLIRYSKRQTISSREIQTTVRLLLPGELAKHAVSEGTKAVTKYTSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0H7</accession>
    <name>A0A401P0H7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0005004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001516">
        <property type="protein sequence ID" value="GCB66662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0H7"/>
    <dbReference type="STRING" id="75743.A0A401P0H7"/>
    <dbReference type="OMA" id="HEPNVGE"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB66662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="181" mass="19535" checksum="AC185D65528ED879" modified="2019-05-08" version="1" fragment="single">ENMVRGLDEDETNYLDEVSRQQVLLEKQRRDEDAKELKECKSARTKLAENTESKKDAEKKATTKPVENKSKFSQAKLLAGAVKRKSSASSDIPKKQKTDNIVGSGHDDDDSCDQAQSDFLTGPAIQHPSASVCVGILPGLGAYSGSSDSDAESSSDSDIIISTGGRIISSVFRSHPFTESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1S9</accession>
    <name>A0A401P1S9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0007991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002990">
        <property type="protein sequence ID" value="GCB67099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1S9"/>
    <dbReference type="STRING" id="75743.A0A401P1S9"/>
    <dbReference type="OMA" id="GLVHECK"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19717">
        <property type="entry name" value="bHLH_TS_NGN2_ATOH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032655">
        <property type="entry name" value="Ngn-2_bHLH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF171">
        <property type="entry name" value="NEUROGENIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB67099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="232" mass="25391" checksum="525ED182D7CB6479" modified="2019-05-08" version="1">MAPQSDRCPYKEQGSGKYFQCPTPASTLMPPGGLSVPSEEEMEEGEEEEEPSAARGECKRRPRGRGKARSPKVVQKIKKSRRIKANNRERNRMHNLNGALDALREVLPAFPEDAKLTKIETLRFAHNYIWALTEALRLAEPLVGGPAGEQVGCVGPKQQYLDSGLSSPSPGASGSSWNSFSSPSSSSYTCTLSPGSPAPSEDTYFGQPESIYVHSKQQSDFLQNSSPFHEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2V2</accession>
    <name>A0A401P2V2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0015120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008419">
        <property type="protein sequence ID" value="GCB67475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2V2"/>
    <dbReference type="STRING" id="75743.A0A401P2V2"/>
    <dbReference type="OMA" id="YNSFHTE"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000017">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000047">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010578">
        <property type="entry name" value="SIM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF19">
        <property type="entry name" value="SINGLE-MINDED HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06621">
        <property type="entry name" value="SIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51302">
        <property type="entry name" value="SIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Single-minded C-terminal" evidence="11">
        <location>
            <begin position="277"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB67475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="79875" checksum="F713BC8BB9C287D6" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P424</accession>
    <name>A0A401P424_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prothymosin alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0010314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pro/parathymosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004418">
        <property type="protein sequence ID" value="GCB67871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P424"/>
    <dbReference type="STRING" id="75743.A0A401P424"/>
    <dbReference type="OMA" id="QKTHEDN"/>
    <dbReference type="OrthoDB" id="9950660at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004931">
        <property type="entry name" value="Pro/parathymosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22745">
        <property type="entry name" value="PROTHYMOSIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22745:SF0">
        <property type="entry name" value="PROTHYMOSIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03247">
        <property type="entry name" value="Prothymosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB67871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11917" checksum="0774B85B4DF55899" modified="2019-05-08" version="1">MSDTKSDSKVEISVERVPKDLKKTQEVEPENGKGDTPANGNAGNEENGEEVEENADEVENEESEDIGEDDEEEDEEGDDEECEGAAEKRVAEDAEDDVAKKKQKTDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P562</accession>
    <name>A0A401P562_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Urotensin-related peptide 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urotensin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004456">
        <property type="protein sequence ID" value="GCB68248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P562"/>
    <dbReference type="OMA" id="WKYCVTD"/>
    <dbReference type="OrthoDB" id="9041662at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001483">
        <property type="entry name" value="Urotensin_II"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00984">
        <property type="entry name" value="UROTENSIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019058860" description="Urotensin-related peptide 1" evidence="6">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB68248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15626" checksum="66317E3A60559097" modified="2019-05-08" version="1">MYTWTLICAAAILSAAGRLKALPVFPESSRIQEEFDPRMTEDAVGFLSNDLPSLGARRMADLYSVLPKQEEMVLDMGAAGPQEDTVETLGDNANLVDDMMALLWKLTAAQKLQHPRYTKSVKAALKPRKRACFWKYCVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5I7</accession>
    <name>A0A401P5I7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lateral signaling target protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003104">
        <property type="protein sequence ID" value="GCB68405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5I7"/>
    <dbReference type="STRING" id="75743.A0A401P5I7"/>
    <dbReference type="OrthoDB" id="20035at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051118">
        <property type="entry name" value="LST-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465:SF2">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="92193" checksum="B3B86FE1114D4163" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6P1</accession>
    <name>A0A401P6P1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="3">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0013874</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01007260">
        <property type="protein sequence ID" value="GCB68786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6P1"/>
    <dbReference type="STRING" id="75743.A0A401P6P1"/>
    <dbReference type="OMA" id="LHDFPHF"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF22">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="13">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="12">
        <location>
            <begin position="201"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB68786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="855" mass="89691" checksum="8BC30C06439E567C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P734</accession>
    <name>A0A401P734_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0005386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001667">
        <property type="protein sequence ID" value="GCB68913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P734"/>
    <dbReference type="STRING" id="75743.A0A401P734"/>
    <dbReference type="OMA" id="PMMQQID"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB68913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14834" checksum="E90EADEFC83CA376" modified="2019-05-08" version="1">MVSALDDLGVETAEEATEPSEPDINELCKDMFTKMSAYLQGELTATCEDYKLLENMNKLTGLKYLEMKEIAVNINRNLKDLNQKYASLQPYLDQINQIEEQVTALEQAAYRLDAYSKKLEAKFKKLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9P8</accession>
    <name>A0A401P9P8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="20">2.1.1.357</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">H3-K36-HMTase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Nuclear receptor-binding SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">scyTo_0008467</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60308"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.357"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.357" evidence="20"/>
    <dbReference type="EMBL" id="BFAA01003246">
        <property type="protein sequence ID" value="GCB69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P9P8"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140954">
        <property type="term" value="F:histone H3K36 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15648">
        <property type="entry name" value="PHD1_NSD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15659">
        <property type="entry name" value="PHD5_NSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20164">
        <property type="entry name" value="PWWP_NSD1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19210">
        <property type="entry name" value="SET_NSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000004">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000025">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000093">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000201">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041306">
        <property type="entry name" value="C5HCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047426">
        <property type="entry name" value="PHD1_NSD1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047432">
        <property type="entry name" value="PHD5_NSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047423">
        <property type="entry name" value="PWWP_NSD1_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047433">
        <property type="entry name" value="SET_NSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17982">
        <property type="entry name" value="C5HCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="27">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="25">
        <location>
            <begin position="1163"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="25">
        <location>
            <begin position="1260"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="27">
        <location>
            <begin position="1316"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="AWS" evidence="29">
        <location>
            <begin position="1450"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="26">
        <location>
            <begin position="1502"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="28">
        <location>
            <begin position="1626"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="831"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1100"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1409"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="868"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1117"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1409"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="30">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00066810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="GCB69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1802" mass="201473" checksum="37B6B88B893DF79A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PA81</accession>
    <name>A0A401PA81_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nuclear receptor subfamily 6 group A member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0005604</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001767">
        <property type="protein sequence ID" value="GCB70077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PA81"/>
    <dbReference type="STRING" id="75743.A0A401PA81"/>
    <dbReference type="OMA" id="GYYACSV"/>
    <dbReference type="OrthoDB" id="10006908at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07169">
        <property type="entry name" value="NR_DBD_GCNF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="207"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB70077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43406" checksum="2E0F7480E2EAAD0F" modified="2019-05-08" version="1">MKQESNFMEDDRTDQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANNSWSNNGDSDHSSPGNGISEGNQPSPVSTPSSRSMELNGYTALRDQFMGTPVTAHYQYLPHLFSYAAHSGLLPPQPRNLDPQSHTLVSQLVGAEDLEPLGTPMLIEDGYKVTQAELFALLCRLADELLFRQIGWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYDRQIFGDLADVTSKYAPSDDELQRFSEEGMEVMERLIYLFRKFQQLKVSNEEYVCMKAINFLNQALALNTVESILTFYQSSVEVKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAM6</accession>
    <name>A0A401PAM6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006095">
        <property type="protein sequence ID" value="GCB70168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAM6"/>
    <dbReference type="STRING" id="75743.A0A401PAM6"/>
    <dbReference type="OMA" id="FRYTTHI"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF7">
        <property type="entry name" value="PROTEIN ATG16L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB70168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="142" mass="16008" checksum="9CD16FFF6D78A8C7" modified="2019-05-08" version="1" fragment="single">CVLSGHSAKVTAAKFKCYYREAVTGSHDRTIRVWDLSKTACIHSIPVLSRCSDVVCSDSFIISGHFDKKVRLWDSRARMKTSEIPLQGKVTSLDINPDRTQLLSCSRDDLLNVTDLRMNENRLELRAGGFKCGADWTKAIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAW9</accession>
    <name>A0A401PAW9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0001235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000268">
        <property type="protein sequence ID" value="GCB70267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAW9"/>
    <dbReference type="STRING" id="75743.A0A401PAW9"/>
    <dbReference type="OrthoDB" id="9990815at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB70267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="463" mass="52034" checksum="C4FFF58812A528B4" modified="2019-05-08" version="1" fragment="single">QKTVLFQFVVKFFPPDPGQLQDELTRYLFAQQIKRDLVAGRLHCNDNSVALLLSHIIQAEVGDFNEEQDGTHLQSKIYIPNQERLIHKIMNFHQKLAGRTQKQLAEYMSKGDFKKVPFERRSCTVQSEEDSSVTDLELGRQVKGLPPDLVDTGQSGDTLGKVWQRPAEMGRKESAVDIVFTSELERSRPEADPVLEPSSSSVYTSYASDSGTEAKKYPVQLQKSRQSFHGNRTRKDTDADELTCGNSPEFTIRSQCFSDNFPELDVFVSQSRRVPRHISMDEEIVRPSGMARPISLPARNFLANHGLYQRAVMRGSYGNTLNAVKEEESQQDDSLQPSKRSHSQSDMKTLGLLHVPELTPMANYLPLGWRPNSNKLRPAHMLQRKDALQTTERYISSGTESSDSDSEIISPYFHPRLFGKALRSSALKGGRFSSVSLQSGEGASSDRNAAEGMSHLTIYTDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PAX7</accession>
    <name>A0A401PAX7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0010737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004688">
        <property type="protein sequence ID" value="GCB70275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PAX7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="111" mass="12690" checksum="41ED452B71977F89" modified="2019-05-08" version="1">MFTINRITISTVGKIGKLIYQHVELCHEHAFCINDATQNPNRLLMSAHRRSIHDVEMPALGMDEHSKKSYITRLKSNSEHQLLWAKNGGDFRSTEVLKDGDTLQDKSELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB89</accession>
    <name>A0A401PB89_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0010773</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004707">
        <property type="protein sequence ID" value="GCB70396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB89"/>
    <dbReference type="STRING" id="75743.A0A401PB89"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07847">
        <property type="entry name" value="STKc_CDKL1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000191">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF15">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="15">
        <location>
            <begin position="399"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="681"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="220"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="311"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="975"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="711"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB70396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="116762" checksum="5D539D201A7D0155" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBU2</accession>
    <name>A0A401PBU2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0001320</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Golgi apparatus membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="EMBL" id="BFAA01000291">
        <property type="protein sequence ID" value="GCB70585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBU2"/>
    <dbReference type="STRING" id="75743.A0A401PBU2"/>
    <dbReference type="OMA" id="YRNPERM"/>
    <dbReference type="OrthoDB" id="6072411at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23437">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000019">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 18" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="527"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB70585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="653" mass="74595" checksum="9F0832B030201192" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE09</accession>
    <name>A0A401PE09_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0001547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000355">
        <property type="protein sequence ID" value="GCB71390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE09"/>
    <dbReference type="STRING" id="75743.A0A401PE09"/>
    <dbReference type="OMA" id="GGWINDI"/>
    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019527007" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB71390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="597" mass="66789" checksum="171E1C3435EFB56A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGA2</accession>
    <name>A0A401PGA2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM C-terminal PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003593">
        <property type="protein sequence ID" value="GCB72157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGA2"/>
    <dbReference type="STRING" id="75743.A0A401PGA2"/>
    <dbReference type="OMA" id="ADEMAPC"/>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM C-terminal PH-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB72157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="295" mass="33522" checksum="014CE3B1858899C6" modified="2019-05-08" version="1" fragment="single">ESQESVVGFNMLNYRACKILWKSCVEHHTFFQAKKPLPQEKKILSNYFTLGHRNQNRTVNNQVCHRVIGGMVWNPILRKSLSVEQLETRSLPSRSPPSTPDWPSPRLRHDAQKPRHSSVDNLATEMAYITESEEVFYNYKANIPVIANENDPEPCQKHASHNWSEEQQSPKIVAGDEMQQQFSHCIKRQRRSFTHSENGIDTVAPSDDHLSVSVSHPLDGVDLQFLETYGLKAPNADEMAPCQYYCDDKTNLANTDDSLLWVRMIPDEGKFGFNLKGGVDQKMPLIVSRVSSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGQ5</accession>
    <name>A0A401PGQ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0001926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000451">
        <property type="protein sequence ID" value="GCB72312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGQ5"/>
    <dbReference type="STRING" id="75743.A0A401PGQ5"/>
    <dbReference type="OMA" id="YKMCGRS"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049407">
        <property type="entry name" value="Usp38-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF660">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21246">
        <property type="entry name" value="Usp38-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="505"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB72312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1068" mass="120100" checksum="584B695EDFB48A8E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHB1</accession>
    <name>A0A401PHB1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delayed-rectifier potassium channel regulatory subunit KCNS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Delayed-rectifier K(+) channel alpha subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Delayed-rectifier K(+) channel alpha subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Delayed-rectifier potassium channel regulatory subunit KCNS2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Delayed-rectifier potassium channel subunit Kv9.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Delayed-rectifier potassium channel subunit Kv9.2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Potassium voltage-gated channel subfamily S member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">scyTo_0002015</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000476">
        <property type="protein sequence ID" value="GCB72474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHB1"/>
    <dbReference type="STRING" id="75743.A0A401PHB1"/>
    <dbReference type="OMA" id="CSGRYHE"/>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18426">
        <property type="entry name" value="BTB_POZ_KCNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000029">
        <property type="entry name" value="Potassium voltage-gated channel subfamily S member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000029">
        <property type="entry name" value="potassium voltage-gated channel subfamily S member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF61">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="26">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="432"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00065612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00080555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GCB72474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="475" mass="54344" checksum="3868BBE28D5F0B81" modified="2019-05-08" version="1">MVNETIRTWDPKFEDQAINVNVGGLKRRLSSSTLSKFPNTRLGQLLKCDSEESILRICDDYDVSKKEFYFDRHPGLFPYVLNFYQTGKLHLMDELCVFSFSQEIEYWGINEFFLDSCCRYRYHDRKTESRRKNWDEESDVSSIDTSPDEISDFNRDLLIFRGLKYGNYRKQLWLTLENPGYSIPSRLFSFLSISVVLGSIATMCIHSMPEYQILDEYEDKIDDPRLQIVEHFCIAWFSMEVCSRMLLSPNIKRFCFHPLNMIDIVSVLPFYFTLLVHLIFGHTTDLENLGKVVQVLRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLGVGVCVFSGMAYTAEKDEDVGLDTIPACWWWGTVSMTTVGYGDVVPITVAGKLAASGCILGGILVVALPITIIFNKFSHFYRMQKALEDAVRGSRLSGRQTEGDGAGEGDALEMEVERGQLDDRESRDPERLEKEGASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PI34</accession>
    <name>A0A401PI34_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0006474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002188">
        <property type="protein sequence ID" value="GCB72795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PI34"/>
    <dbReference type="STRING" id="75743.A0A401PI34"/>
    <dbReference type="OMA" id="CAVPKKG"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12394">
        <property type="entry name" value="RRM1_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="161"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="264"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB72795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="408" mass="45546" checksum="AC8AC9EE25B1582B" modified="2019-05-08" version="1">MGKKERKESKGMSEETGSYVVGQVANSLFWKQAGQCKLTPLVTLFTTPSSATQPVFTPVPTNKVSCKKRKLAEDESDVTNKGKQQKLEKRKPVHDKQLTAAERKLAQREDALRAADEEGEGKRRRNPKRSEEAAQGKLPYAAAMPKGNAANHALERIKNRRTLFIGNLPSECSKQMVTAMFKEFGPIESVRFRSVAPVEPNMSRRLATIQKKIHPKRNNMNAYIVFEQDSDAVRALTRNGYEIQTGFHIRVDLASGSNIHDHRRSIFLGNLSYEIGEDEVRDHFCECGEIESVRIVRDRVSGMGKGFGYVLFQSTDAVTLALELNNSELKGRKVRVSHSMKKDTAVKTRTRSPWGTAMKARAEKKTPLAKGFAGVMAKPAEGKKAKKKKKGQKSKSNQGKASKSRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJL9</accession>
    <name>A0A401PJL9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pleckstrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0002480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000623">
        <property type="protein sequence ID" value="GCB73329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJL9"/>
    <dbReference type="STRING" id="75743.A0A401PJL9"/>
    <dbReference type="OMA" id="GTCVIDW"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP_dom"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF1">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEP"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="40"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="156"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="264"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB73329.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42503" checksum="E9F400293763E4F4" modified="2019-05-08" version="1">MMTATHALGSTFLFIHQDEDDHVHHQECLVVLWWGTVFNSWKAVWVVLYEDVFEFYSKKDDGSPKGIIPLKGSMVTSPCLNYSKRLFVFKFHTAKNQDHFLQATHLEERDAWVKDIKRAIECIEGGQKFARKSTRKSIKLSENINLGALYLSMKDPETGVKELKLQKDKKVFNHCFAGASVIDWLLSSNFVRNRREGLMLAAALICDAYIQPAEEKAKAAAEQASESCFVDDSDAYYFFADSGFFSEGSSSDDDELLKEEFRGVIIKQGCLLKQGHRRRNWKVRKFVLRDDPAYLHYYDPTADDQDQPLGSIHLRNCVVTATDGPPDGKKSEVKRNLFEIITADEVHYLIQAATREELAEWIKVIKSVASTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJT6</accession>
    <name>A0A401PJT6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0002509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM149 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000631">
        <property type="protein sequence ID" value="GCB73375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="VPATRNK"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022194">
        <property type="entry name" value="DUF3719"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039630">
        <property type="entry name" value="FAM149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997:SF2">
        <property type="entry name" value="PROTEIN FAM149A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12516">
        <property type="entry name" value="DUF3719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3719" evidence="3">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB73375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="693" mass="76808" checksum="B1C1C6C2B98E7FC6" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLJ3</accession>
    <name>A0A401PLJ3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000800">
        <property type="protein sequence ID" value="GCB73961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PLJ3"/>
    <dbReference type="OMA" id="EQHNSPA"/>
    <dbReference type="OrthoDB" id="5990677at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039878">
        <property type="entry name" value="RBM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="813"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="885" mass="100125" checksum="3B8681ECD581596E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLM0</accession>
    <name>A0A401PLM0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">3'(2'), 5'-bisphosphate nucleotidase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Inositol monophosphatase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Myo-inositol monophosphatase A3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0003104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01000823">
        <property type="protein sequence ID" value="GCB74020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLM0"/>
    <dbReference type="STRING" id="75743.A0A401PLM0"/>
    <dbReference type="OMA" id="PEITIIC"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052834">
        <property type="term" value="F:inositol monophosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000007">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF4">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB74020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="234" mass="25404" checksum="3C1D06C45D947358" modified="2019-05-08" version="1">MLISEEHDTSKVNKSLTWNYEIPNLIQESIVNARMVSTESVTVWIDPLDATQEYTEDLKHFVTTMVCVAVDGKPVIGVIHKPFSKYTAWAMVDGASNIHPRKAYNEKTPTVIVSRSHAGAVKSYCQGAFGNGTTILPAGGAGYKVLSLLDSGEGTQLDSADVYIHVTFIKKWDICAGNAIMKALGGQMTTIEGDFIDYSDFSSNNGGLVASIGIDHHALLKRLPDLKSLALKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLZ2</accession>
    <name>A0A401PLZ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sideroflexin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0003188</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alanine(in) = L-alanine(out)</text>
            <dbReference type="Rhea" id="RHEA:70719"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteine(in) = L-cysteine(out)</text>
            <dbReference type="Rhea" id="RHEA:29655"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-serine(in) = L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:35031"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000855">
        <property type="protein sequence ID" value="GCB74101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLZ2"/>
    <dbReference type="STRING" id="75743.A0A401PLZ2"/>
    <dbReference type="OMA" id="GRREYKM"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF8">
        <property type="entry name" value="SIDEROFLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB74101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="428" mass="47187" checksum="8D3FC9A3F82BF203" modified="2019-05-08" version="1">MVDSRTCGPAVASADCVTCAEALRPAAPPPTLAENGTPRAPPTPPRHVLGLLGRARCQAQHFRVKRVLELEPGLRTEQSGRREYKMTGEISLNINTKEPRWDQGTFIGRAKHFFTVTDPRNILLSNAQLENARKIIHDYRQGIIAPELTEDELWRAKYVYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYKTTPAVVFWQWINQSFNAIVNYTNRSGDAPITVGQLGTAYVSATTGAVATALGLNSLTKVLLTSDMCIFYQLMDLGIVAKHVTPLIGRFVPFAAVAAANCINIPLMRQRELKHGIPITDENGNRLGESTKAAQQAIVQVVISRILMAAPGMAIPPFIMNTLERKAFLKRFPWMSAPIQVGLVGVCLVFATPLCCALFPQKSSMSVNRLEHDIQAKVRKTSPGVEYVYFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP25</accession>
    <name>A0A401PP25_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0019675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Ruffle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014878">
        <property type="protein sequence ID" value="GCB74884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP25"/>
    <dbReference type="STRING" id="75743.A0A401PP25"/>
    <dbReference type="OMA" id="QDFVTMM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000106">
        <property type="entry name" value="Allograft inflammatory factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049025">
        <property type="entry name" value="AIF-1_EF_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042433">
        <property type="entry name" value="AIF1/AIF1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10356">
        <property type="entry name" value="ALLOGRAFT INFLAMMATORY FACTOR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10356:SF0">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21008">
        <property type="entry name" value="AIF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB74884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="172" mass="19724" checksum="8E6B1EC1CB618AA6" modified="2019-05-08" version="1">MPSGQQAQGGKMFGLLKAQQQERLDSVNKEFLEDEKYKDEEDLAESLESFKKKYMEFDLNDQGDIDLMSLKQMLEKLGVAKTHLEVKKMIAEVTGDSSETISYCDFVTMMLGKRSAVLRLFDLIFSSDIDIPTFNEFRALSPFTRIYSEGAVRKVKQIQGSKKTKNRMKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPP7</accession>
    <name>A0A401PPP7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cellular tumor antigen p53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0019724</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Binds DNA as a homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the p53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014968">
        <property type="protein sequence ID" value="GCB75097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPP7"/>
    <dbReference type="STRING" id="75743.A0A401PPP7"/>
    <dbReference type="OMA" id="DFFSQDV"/>
    <dbReference type="OrthoDB" id="5915660at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08367">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000002">
        <property type="entry name" value="Cellular tumor antigen p53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.170.10:FF:000001">
        <property type="entry name" value="Cellular tumor antigen p53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000020">
        <property type="entry name" value="Tumor protein 63 (p63)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057064">
        <property type="entry name" value="P53_central_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010991">
        <property type="entry name" value="p53_tetrameristn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF8">
        <property type="entry name" value="TUMOR PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07710">
        <property type="entry name" value="P53_tetramer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47719">
        <property type="entry name" value="p53 tetramerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00348">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0010">Activator</keyword>
    <keyword evidence="3 14" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5 12 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAM" evidence="15">
        <location>
            <begin position="340"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="13">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB75097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="479" mass="54031" checksum="2E6EF9EBA9D218CF" modified="2019-05-08" version="1" fragment="single">SPELKKLYCQIAKTCPIQIKVMTQPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNDGQVAPPSHLIRVEGSSHAQYVEDPITGRQSVMVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIVTLENRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVTEGTKGVDTSKRLRHVNQGIQVASITSKKRRPGDEELFYLPIRGRETYEVLLKIKESLELMQLLPQHTIESYRQQQQHLLQKQPSMQSQQSFGPSPPPMNKMATMGNKLPSVSQLISPQRNALTQAPMPGSMVPQMMNMPMQMNGDMNGLSPTHGLPSPMASTSHCTPPPPYPSDNSISSFLTRAGCASCLEYFTTQGLMNIYQIEHFTMDDLISLKIPEQYRHAIWKGILDHRQTLDYANPPQLLRNTSSASTASMGSQNETRGERVIDAVRFTLRQTISFPPRDDWNDFGFDMDGRRSKQRIKEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQM0</accession>
    <name>A0A401PQM0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein O-mannosyl-transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0020908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017634">
        <property type="protein sequence ID" value="GCB75415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQM0"/>
    <dbReference type="STRING" id="75743.A0A401PQM0"/>
    <dbReference type="OrthoDB" id="5561486at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ArnT-like N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB75415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="85" mass="9228" checksum="C2900CF26D154F37" modified="2019-05-08" version="1" fragment="single">RDLEDQADSPVALKMLIGLAGYLTGYDGTFPFKKPGDKYEQHHYYGMRALCATLGSCLVPFAYLIVLELSGSLTAALLAAVLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQR1</accession>
    <name>A0A401PQR1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylhydrolase ARH1</fullName>
            <ecNumber evidence="4">3.2.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-ribose-L-arginine cleaving enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylarginine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0019013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.19" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01013762">
        <property type="protein sequence ID" value="GCB75464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQR1"/>
    <dbReference type="STRING" id="75743.A0A401PQR1"/>
    <dbReference type="OMA" id="ECARMTH"/>
    <dbReference type="OrthoDB" id="10250509at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003875">
        <property type="term" value="F:ADP-ribosylarginine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF26">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB75464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="276" mass="30332" checksum="88F76E02CE3689B8" modified="2019-05-08" version="1" fragment="single">LMLCNIYFLPGVTCLKSVSLLKPDLSDGWKTSFNPAGGGCGAAMRAMCIGLRFPRPEELDKLIEVAVESGRMTHHHPTGYLGSVAAALFTAYAVNNKPVVSWGAGLMEVLEKAKSYVAKAGHYDAENLAAWSYFEDQWKKYLRDRGILDGVSKPTFPKQYNVIERDKFYTSVSYSGWGGASGHDAPMIAYDAILGSGSSWEELCNRGVFHGGDNDSTGAIAAAWWGAMYGFDQVPKSHYKDLEYRSRLESLAEKLFYLSHTNSCSSQKSQKSCSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRJ9</accession>
    <name>A0A401PRJ9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferlin B-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0018255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012540">
        <property type="protein sequence ID" value="GCB75745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRJ9"/>
    <dbReference type="STRING" id="75743.A0A401PRJ9"/>
    <dbReference type="OMA" id="FTEGKFF"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ferlin B-domain" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB75745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="87" mass="9971" checksum="FB694762205816AE" modified="2019-05-08" version="1">MLSGDKRVAYARIKAYSVLFSRDSEKSCGKFCGKLLTVFMKQPLDRSQDMRSVAQLRVRIWMGLSSDEEEFEKYIDGKILVAAERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRN3</accession>
    <name>A0A401PRN3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008699">
        <property type="protein sequence ID" value="GCB75789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRN3"/>
    <dbReference type="STRING" id="75743.A0A401PRN3"/>
    <dbReference type="OMA" id="FFTTWCQ"/>
    <dbReference type="OrthoDB" id="1899781at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02999">
        <property type="entry name" value="PDI_a_ERp44_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042418">
        <property type="entry name" value="TXNDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019130818" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="160"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB75789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="365" mass="39804" checksum="C49926DA617D0E63" modified="2019-05-08" version="1">MLTSVGRMGGFGTKAILIVALLMVTGVSANAEVQRDDSPSKHLSTEESDVTSNSASNVELERMDEQIKRKVQFPTAEIADAVLGTGIHSNPEAILSLIQNIKNEHPVFEVKDTPCTDVSGENGECSVPEEIFPSLTYIPSGNQEGEILGERETGILEPVPAENPAAEEANATETARAPKVNCDERNMTGLENFIVQILNSTQDLMEFLNANGTDCSVVLFYTPWCRFSADLGPHFNALPRAFPSLQFLALDASQHSSLSTRFGTVAVPNILLFQGVKPMARFNHTDRTLSTLRAFIFNQTGIEANGTVEVMEQDLSGPLPSVAVRGIDWLLVFSVFFVCVFLVYGTVQSDGIKWLVTGQEHEHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRR9</accession>
    <name>A0A401PRR9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0020951</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017723">
        <property type="protein sequence ID" value="GCB75829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRR9"/>
    <dbReference type="STRING" id="75743.A0A401PRR9"/>
    <dbReference type="OMA" id="WGNLYGA"/>
    <dbReference type="OrthoDB" id="8716763at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015057">
        <property type="term" value="F:thrombin-activated receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000040">
        <property type="entry name" value="Coagulation factor 2 (thrombin) receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003944">
        <property type="entry name" value="Prot_act_rcpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003912">
        <property type="entry name" value="Protea_act_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF22">
        <property type="entry name" value="PROTEINASE-ACTIVATED RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01428">
        <property type="entry name" value="PROTEASEAR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01430">
        <property type="entry name" value="PROTEASEAR4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="136"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="191"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR603912-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB75829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="424" mass="48032" checksum="9C3AA6E1328EBCBB" modified="2019-05-08" version="1" fragment="single">ISTMTFQFPLPSPPESIVHYRLRTVCTGTLEEKLSEMNYNLLLLLTLTTFRNRVAVCYSLEYDDYSDNSSDDSPNNPAMGQAPDIRSFAGVTIYLNGSNETIMTVGERAKGFLTGPISTAIIPAFLILVFVIGLPANGLALWIMATKIRKLPSTIFLINLATADLLLILMLPFKIAYHLLGNDWLFGEGLCRAMTAFLYGNMYCSILLLTFISIDRYFALVRPFLSKRFRDNRFAVCGCSVIWVFAVLLVSPFLFEDQLYTVQDLNITTCHDVLQPGKLAAYFFYYFTCLVIVGFLIPCCITVFCYGSVIQALILTEKRYIRAAVVTALILLVYVVCFTPSNITLLIHYSEYHLTEGSDLYIYYMVCLVLSSSSSCIDPFIYYYLSDEFRFKVRQVIFCRKGKGRELSGKTSQELLRTTMTHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSG7</accession>
    <name>A0A401PSG7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-induced degradation protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012593">
        <property type="protein sequence ID" value="GCB76033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSG7"/>
    <dbReference type="STRING" id="75743.A0A401PSG7"/>
    <dbReference type="OMA" id="HWSKFQC"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="24111" checksum="2D6D025C3D1ED236" modified="2019-05-08" version="1">MPVRTESASLIPPPPINTQQPGVATTLLYSGSKFRGHQKSKGNSYDVEVVLQHVDMENSFLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTRKWDADEDVDRKHWGKFLAFYQYAKTFNSDEFDYEELKNSDFVFMRWKEQFLVPDHTIKDISGASFAGFYYICFQKSTASIEGYYYHRSSEWYQSLNLTHVPEHSTPIYEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSP3</accession>
    <name>A0A401PSP3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translational activator of cytochrome c oxidase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0019098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013902">
        <property type="protein sequence ID" value="GCB76159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSP3"/>
    <dbReference type="STRING" id="75743.A0A401PSP3"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.980:FF:000008">
        <property type="entry name" value="Translational activator of cytochrome c oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="12">
        <location>
            <begin position="324"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="11">
        <location>
            <begin position="401"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB76159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="564" mass="63321" checksum="DAEE8CE93D7CCABE" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSW7</accession>
    <name>A0A401PSW7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0018314</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012634">
        <property type="protein sequence ID" value="GCB76220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSW7"/>
    <dbReference type="STRING" id="75743.A0A401PSW7"/>
    <dbReference type="OMA" id="KMEFAIY"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="213"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB76220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="353" mass="39124" checksum="D007702756315A7B" modified="2019-05-08" version="1">MPSDKTIGGGDDSFNTFFSETGAGKHIPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHCSIGKEIVDLVLDRIRKVADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKMEFAIYPAPQISTAVVEPYNAVLVTHCTLEHSDCAFMVDNEAIYDVCRRNLDIERPTYTNLNRLMAQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLLTYAPLISAEKAYHEQLSVSEITNSCFEPANQMVKCDPRQGKYMACCMLYRGDVVPKDVNAAIATIKTKRSITFVDWCPTGFKCDILIGDNGRGDERIERNGDKKNSADLLGDTSNGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUC6</accession>
    <name>A0A401PUC6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015347">
        <property type="protein sequence ID" value="GCB76746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUC6"/>
    <dbReference type="STRING" id="75743.A0A401PUC6"/>
    <dbReference type="OMA" id="ERADMME"/>
    <dbReference type="OrthoDB" id="8964674at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="beta-Roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="198" mass="23168" checksum="6B345DD3919E695C" modified="2019-05-08" version="1">MMQLNDGADMMELNDRADMMELNDRADMMELNDGADRMELNERQDTMELNDGADRMELNERADMMELNDRADMMELNDRADMMELNDRADIIELNDGADRMELNERQDTMELNDGADMMVLNDGADRMELNERADMMELNDRAGMMELNDRADMMKLNDRANMMELIDRSDMMEMKDRADMMELNDRADIMELNDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUF5</accession>
    <name>A0A401PUF5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014018">
        <property type="protein sequence ID" value="GCB76703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUF5"/>
    <dbReference type="STRING" id="75743.A0A401PUF5"/>
    <dbReference type="OrthoDB" id="2421264at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052949">
        <property type="entry name" value="PA_immunity-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42999">
        <property type="entry name" value="ANTIBIOTIC RESISTANCE PROTEIN MCBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="492" mass="56832" checksum="D32A19739A933B78" modified="2019-05-08" version="1">MEPGREGQGQAEPGHEGQGQAEPGHNGHGPMGPGRPEPDCKGQGQAEPDRAEPDPTVPGRAGPGRAEPGPTGPGRAEPGPTGPGRAEPGRKGPGRAEPGATEPGQTESGTTGPGRAGPGQWELGRARPRATGPGPAEPGPAEPSHDGKVQWNQVERDKVEQNQVARDKVRQNQVKWNQVEREKVKQNQVTMDKFQWDQAERNQIARDKVKLNQIERNQIQQDQVEWNQVERNHVAWHKVQQNQVERNQVKRDQVKRDQVQRDQVKRDPGPGREGPGRVEPGREGPGRVEQAERDQAEWDQAEWNQVEWYQVESNKAKRDQGEWNQARRDKIQWDQAEWNQVQRDQVEWNQVQRDQVERNQVQRDQVERNQVQQDQVKRNQVARDKVKRNQAKQNQIQRDQVERNQVQRDQVERNQVQWDQVERNQAARDKVKWNQIAMDKVRWDQVEQNQVAMDQVERNQVQRDQVERDQVERNQVQWDQVEWNQAERDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUY7</accession>
    <name>A0A401PUY7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0017519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011474">
        <property type="protein sequence ID" value="GCB76927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUY7"/>
    <dbReference type="STRING" id="75743.A0A401PUY7"/>
    <dbReference type="OMA" id="LCDEVST"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003543">
        <property type="entry name" value="SR-AI/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF24">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01408">
        <property type="entry name" value="MACSCAVRCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="311"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="58"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="336"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="349"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB76927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="413" mass="45496" checksum="FA03875D3AB20CB5" modified="2019-05-08" version="1" fragment="single">PRYQRPSADWKILSDNVTNLGEGFKDMRQTMEQKAPKDDVTDNILKLHELFRNHSVLFFQLSQSVQKLENKLQSFEARMDDINASVNDLEDDLQQFSSTNRQEIYNLSTSLNSAQGTLQHQQANLKQITSNVGNLSRQIKEAHWTLNAVNSTITEDISIHHTSLLRLQIQLANVSEDAKILKAVQQNMEKQLKEEVAILNNVTEDLKLKDWEHSITLKNLTLVQGPPGPKGDKGDEGLDGFPGPIGATGKRGISGLTGEPGTIGLKGDPGERGLPGISVKGQKGSWGRRGERGRKGEKGEKGDNGEIGPVIRLVNGSGPHEGRVEVFYDQLWGTVCDDKWDKPDAEVVCRMLGFKEASEIHTANKFGQGTGRIWMDDVACTGAEDTILQCKFSGWGKTNCGHAEDAGVICKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV76</accession>
    <name>A0A401PV76_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tectonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018009">
        <property type="protein sequence ID" value="GCB77041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV76"/>
    <dbReference type="OMA" id="VWGVNTH"/>
    <dbReference type="OrthoDB" id="166585at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF3">
        <property type="entry name" value="FISH-EGG LECTIN-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="247" mass="27264" checksum="BC2D71ED78A50456" modified="2019-05-08" version="1" fragment="single">TAHALATRCTDIAGTMKQIDAGIGMVFGVNYTGSVYTRLRDSWIRIPGTLKHVTVGPAGVWGVDHKRKIFRMTSGTLNPIFNGELIQLDAGGERILAGVDQFGSTFCINSQDLAAVTDNRSATFNSIGSRMRYYSCGPLGCWGVTLARDVYYRLNVKPSSCIGTSWTRVFGKFQNIEVGSDGRVFGISVTQQLYMRKGISLDRPTGWGWTKIQIGNLRFNHASWDLGHLWLVRTDGKIVKCSSEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVT9</accession>
    <name>A0A401PVT9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016770">
        <property type="protein sequence ID" value="GCB77239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVT9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="101" mass="9606" checksum="0CEDA3CD03CB5E17" modified="2019-05-08" version="1" fragment="single">FAFGQVTSAPGATTSAPATQGFSFGAKAAAPSTATPAAGPTLFASMVSSVPPATSVATSFTLTSSAAPVPAVPAPSTTSAPFGFKPTSTTIPVTTATPLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW30</accession>
    <name>A0A401PW30_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0016664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINAR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010240">
        <property type="protein sequence ID" value="GCB77329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW30"/>
    <dbReference type="STRING" id="75743.A0A401PW30"/>
    <dbReference type="OMA" id="NESFECC"/>
    <dbReference type="OrthoDB" id="8875526at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039706">
        <property type="entry name" value="MINAR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009626">
        <property type="entry name" value="MINAR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055117">
        <property type="entry name" value="MINAR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530:SF2">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1 MINAR1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06789">
        <property type="entry name" value="MINAR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22948">
        <property type="entry name" value="MINAR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="MINAR1 N-terminal helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Major intrinsically disordered Notch2-binding receptor 1-like C-terminal" evidence="8">
        <location>
            <begin position="715"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB77329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="872" mass="97708" checksum="1AF04946C1096BE4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW47</accession>
    <name>A0A401PW47_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0021089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018085">
        <property type="protein sequence ID" value="GCB77322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW47"/>
    <dbReference type="STRING" id="75743.A0A401PW47"/>
    <dbReference type="OMA" id="MDGEDWI"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000071">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB77322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="262" mass="29938" checksum="90DF5082EE4989D0" modified="2019-05-08" version="1">MESVARGAVSSDIKRDMLRCQQHYDLVYCTHWILTALNYFQEVNALECEIQLLKNLHHERIVQYYGCLRDPQERTLSIFMEYMPGGSIKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPPHVSDHSRDFLKKIFVEVKQRPSAEELLRHTFVHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW98</accession>
    <name>A0A401PW98_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MANSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0018465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012888">
        <property type="protein sequence ID" value="GCB77401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW98"/>
    <dbReference type="STRING" id="75743.A0A401PW98"/>
    <dbReference type="OrthoDB" id="10071013at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011106">
        <property type="entry name" value="MANSC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876:SF3">
        <property type="entry name" value="MANSC DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07502">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00765">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50986">
        <property type="entry name" value="MANSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019009925" description="MANSC domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MANSC" evidence="8">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB77401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="184" mass="20945" checksum="3BA8E15E8C51283C" modified="2019-05-08" version="1">MIWHHSESFLLLLLTILTNHKSLLQESDCTGSDTGIMDAIIDVKVALTKGMVSLAPFHTDTVEECHDECCSDLPVTGEHLCNFITFNPRKKSSYQNCYLFYCPDKDACPLMESKGYISHFIHRELKNIRDESTEETYFHRGEESSDDGIAPDLLNKLTFNPTQITSHHGVWMKSKLYKLENIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWL6</accession>
    <name>A0A401PWL6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosidase endo-alpha like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0016688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 99 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010264">
        <property type="protein sequence ID" value="GCB77443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWL6"/>
    <dbReference type="STRING" id="75743.A0A401PWL6"/>
    <dbReference type="OMA" id="TMHENIR"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11574">
        <property type="entry name" value="GH99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000019">
        <property type="entry name" value="glycoprotein endo-alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="ENDO-ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572:SF2">
        <property type="entry name" value="GLYCOPROTEIN ENDO-ALPHA-1,2-MANNOSIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB77443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31664" checksum="938A9FA7FEC73DBB" modified="2019-05-08" version="1" fragment="single">GVLVLSWYPSGLEDENSEQMDDLVPAILDAADKYSLKVAFHILPYMGRNDHTVSENIKYIVDKYGSHSTFYKYRTSTGRLLPMFYIYDSYLTLPAAWANLLTSSGSHSIRNTPYDGVFIGLIVEEKHKQDILESGFDGLYTYFASNGFSFGSSHQNWKIIKNFCDSNNLMFIPSVGPGYIDTRIRPWNNHNTRNRVSGKYYETALHAALTVRPEIISITSFNEWHEGTQIEKAVPKKTAQYTYLDYLPHEPNLYLELTHKWAEHFCKEKEQWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX32</accession>
    <name>A0A401PX32_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011609">
        <property type="protein sequence ID" value="GCB77603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX32"/>
    <dbReference type="STRING" id="75743.A0A401PX32"/>
    <dbReference type="OMA" id="CGGVKHA"/>
    <dbReference type="OrthoDB" id="6266673at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13192">
        <property type="entry name" value="FERM_C_FRMD3_FRMD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000043">
        <property type="entry name" value="FERM domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000006">
        <property type="entry name" value="FERM domain-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF5">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="409" mass="46257" checksum="9B54FD04210864BB" modified="2019-05-08" version="1">MCFRVKFYPTDPSALKEEITRYLVFLQIKRDLYHGRLLCKTSDAAQLAAYILQAEIGDYDAGKHPEGYSSKFQFFPKHSEKLERKIADIHKAELSGQSPDTAELNFLTQAQSLETYGVDPHPCKDVSGNAAFLAFTPSGFVVLQGNKRIHFIKWTDVSKMKFEGKTFNLYAIQKEESKIILTYFAPTPEACKHLWKCGVENQAFYKFEKSSQVRTVSSSNLFFKGSRFRYSGKVAKEVIESSAKIKRSPPEIHRSGLVPSRSCPSISHGSRLSSVPRTRRRAVHISIMEDISEQTGSEERVFSEKRDSEERDFSEKSGSEERDFSEESGSEEGDVSEESGSEERDFSEESGSEEQDFSEERGSEEGDVSEESGSEEREASVMRAAVKSKTSVKRETSVRRAAVKRERLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYB6</accession>
    <name>A0A401PYB6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0016777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with LGALS1 and laminin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010374">
        <property type="protein sequence ID" value="GCB78033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYB6"/>
    <dbReference type="STRING" id="75743.A0A401PYB6"/>
    <dbReference type="OMA" id="QMRCGEA"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000031">
        <property type="entry name" value="RIKEN cDNA 5830411N06, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF15">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="35"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="140"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="245"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="350"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="455"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="60"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="270"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="283"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="375"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="388"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="480"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="493"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB78033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="699" mass="74767" checksum="9BF4655C4A6E770F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q112</accession>
    <name>A0A401Q112_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0015932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009295">
        <property type="protein sequence ID" value="GCB79087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q112"/>
    <dbReference type="STRING" id="75743.A0A401Q112"/>
    <dbReference type="OMA" id="CESTHNT"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15291">
        <property type="entry name" value="7tmC_GABA-B-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002456">
        <property type="entry name" value="GPCR_3_GABA_rcpt_B1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB79087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="367" mass="41771" checksum="E55E91746F4F52CC" modified="2019-05-08" version="1" fragment="single">YIQNSQPYLNNMTAVGCTLALAAVFPLGLDGYHIHQWHFPLVCQARVWLLGLGFSLAYGSMFTKIWWVHTVFTKKDDKKEKRKHLEPWKLYATVSVLLAIDVLTLAIWQIVDPLHLTVEEFSKEAPEGDQGVLILPQLEHCSSNKMNTWLGIVYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCMITAPVTMIVSSQQDAAFAFASLAVVFSVYITLVVLFVPKMRRLITRGEWQSEQQDTMKTGSSTNNNDEEKSRQLEKENRELEKIIAEKEERISELRQQLYERQQLRSRRRPSNTPKENYTNNHFGNSSAGTVSSLYQPNLPLVKCLVSAEQTDKLGRNNCDGSRIHLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q113</accession>
    <name>A0A401Q113_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017216">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10820" checksum="5EC6EC657A9E88DD" modified="2019-05-08" version="1" fragment="single">QYFGVDEAQFEAVTAENQRLREELEKLEKEKQNEPDRVQALEKTRASLQKDRQKYKNYLEEMEQHKTLLEQRTKGIKEEIESAGIDLYSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A401Q2C9_SCYTO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="78101at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055310">
        <property type="entry name" value="CEP112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18871">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 112 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18871:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 112 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="GCB79589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="8191" checksum="04CDCC272F96FF30" modified="2019-05-08" version="1">MKKKLKKRNQSLVRESQIIRKSKEHRIFELQKMAEQSVDSLRNDWERKLHNAEAGPEQEKFGLQNRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4K9</accession>
    <name>A0A401Q4K9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
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                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010883">
        <property type="protein sequence ID" value="GCB80301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="EEQMHRE"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="348" mass="46204" checksum="805303B640902F33" modified="2019-05-08" version="1">MREREKRQRERKDREREKEKEREREKRERKKDRERESEKEKERREREKERQREKTEREREKRQRERKDRGREREREKRERERKRKREREERERKKDREKTEREREKRQRERKDREREREREREKEKERERKREREEREREEREEERQRERKRKRERKEREREKKTERESKRERREREKERQGEKTQREKEREREEREREREKERQREREREKERERKDRQRERKKDREREKEKERERREREKERQREKTERERKRKREREEREKERQREKTEREREREREREKRQRARERDLDVISLLSANNEIQLPADIDNPQFPVEKMFDGRVLKVLPQCCWSIGKGRICSRDIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5X1</accession>
    <name>A0A401Q5X1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">Cloudy catshark</name>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
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                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB80779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5X1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="64" mass="7271" checksum="8117B66D08D52230" modified="2019-05-08" version="1" fragment="single">FVRSCLTPAHACTLKQNPFLYGRTVFSSLSIKGFIKFTRIHATKKFVNLLYTENLETEGCSDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6P5</accession>
    <name>A0A401Q6P5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrin alpha-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
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                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022559">
        <property type="protein sequence ID" value="GCB81055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="75743.A0A401Q6P5"/>
    <dbReference type="OMA" id="PAYTCVF"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF118">
        <property type="entry name" value="INTEGRIN ALPHA-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11533" checksum="A08334E77CEEA49F" modified="2019-05-08" version="1" fragment="single">ANPQDVKLTTYAKVGYDENKYIHVSQATNRFQEAKVTTRVEIVKEVNQLPIIIGSTIGGLALLAIVAGVLYKVGFFKRGYKAKLEDAGDEGSGGVTTDASTPSTNAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q758</accession>
    <name>A0A401Q758_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAM234A/B beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0021789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020027">
        <property type="protein sequence ID" value="GCB81167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q758"/>
    <dbReference type="OMA" id="WEKDLIC"/>
    <dbReference type="OrthoDB" id="6364780at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF7">
        <property type="entry name" value="PROTEIN FAM234A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="5">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB81167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="183" mass="20902" checksum="21B81AC560BB3078" modified="2019-05-08" version="1" fragment="single">APVSGYYNMDDSFDFLIEDFIEKDKKKVTILDGRSGTVLWEKDLICRKNCPNPSSINTVSQSTFLFWGELPTQDNGSVPEDLTANRHYLYMVHPSHPNIILELRNSTENVLAYTTALFERSRHACNVLLTGQPIGSKPGPLTITKQKLKDTISMSTVRRLNQGNDGFSDVELKEYFYRMRYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8U5</accession>
    <name>A0A401Q8U5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025610">
        <property type="protein sequence ID" value="GCB81747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8U5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="158" mass="17479" checksum="3BD2E979AABEE4BA" modified="2019-05-08" version="1">MRAFTPESGDSDPGAECEEIKEEPCEYADPDNVMGVDPFQTREPMAFPDNFPAPMNLLTANGQNANVTYITPYTVAQLTDIAKTIEVFEPTEDPNALFENTCQHGRDVARTGGQTDLNVLDPSLIALYNWRDTLTHGNLQRSGLSCGLPHVYEIKNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9S9</accession>
    <name>A0A401Q9S9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrin alpha first immunoglubulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0022281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021932">
        <property type="protein sequence ID" value="GCB82116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9S9"/>
    <dbReference type="STRING" id="75743.A0A401Q9S9"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF26">
        <property type="entry name" value="INTEGRIN ALPHA-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0401">Integrin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB82116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="166" mass="18964" checksum="1F49A843111D5D51" modified="2019-05-08" version="1" fragment="single">MLQRNCRRNGNDVTCVTATACFTARAKSPGLGNSTLDLHYNILLDEEKFAPRGLFDEGEQRQRHDVIHILIDGQKCHKFQFHVIDTADYIRPIGFRLGFRLEERPSGPVLDDSCLTTVRSWIPFFKDCGEDDECLTDLRLQAQLDISGSRQEDKIYHCCQSSPFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAI6</accession>
    <name>A0A401QAI6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027332">
        <property type="protein sequence ID" value="GCB82380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAI6"/>
    <dbReference type="STRING" id="75743.A0A401QAI6"/>
    <dbReference type="OMA" id="QFASRER"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF81">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB82380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10036" checksum="74AA4F795116AD60" modified="2019-05-08" version="1" fragment="single">KDHETLNVLKFVRPGGDFVPRFPVFGKIEVNGETEHPLYTFLKVSCPFVNPVIGDGTRLHWSPLKVSDVRWNFEKFLVDVDGQPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAL5</accession>
    <name>A0A401QAL5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027354">
        <property type="protein sequence ID" value="GCB82411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAL5"/>
    <dbReference type="STRING" id="75743.A0A401QAL5"/>
    <dbReference type="OMA" id="PTFAYPN"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="93" mass="10714" checksum="CA5BB70BAA8D773C" modified="2019-05-08" version="1" fragment="single">PCVWSQDHVRQWLDWAVKEYSLSDIDSSLFQNIDGKELCKLTKDDVTRLTTTYNAEILLSHLNYLRENSPTFAYPNSNSHSQQPVRAPVKTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBE8</accession>
    <name>A0A401QBE8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021052">
        <property type="protein sequence ID" value="GCB82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBE8"/>
    <dbReference type="STRING" id="75743.A0A401QBE8"/>
    <dbReference type="OMA" id="SHKYIHY"/>
    <dbReference type="OrthoDB" id="10606588at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="130" mass="12407" checksum="73642B9C6C27DE93" modified="2019-05-08" version="1" fragment="single">GDGVSLVSDVIGDGVLLVSNVTGGGVSLVSDVTHDGVSLVSDVTGDGVSLVSEVTGDGVSLVSDITGDGVLLVSDVTGDGVSLVSDVTGDGVSLVSDVTGGGVSLVSDIADDGFLLVSDVTGDVVSLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDN9</accession>
    <name>A0A401QDN9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01041133">
        <property type="protein sequence ID" value="GCB83473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDN9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="168" mass="19047" checksum="DA1D4D77A7727FA9" modified="2019-05-08" version="1">MMLHIHRVEENSTHELLQVNNLGYYGNGVLVKLKDAPAHAIQRASRIFSIDLRVCKGGGGNNWLCLERATSTEDYCGYTTYGNCTLAVELTNQTVFNRAQYLDNYCIVNSYHNYTKRGIVCELPGHNVVLTNLSESITIGRHELTPYRDVSIVEADDLERIDNDQRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDY3</accession>
    <name>A0A401QDY3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01038951">
        <property type="protein sequence ID" value="GCB83609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDY3"/>
    <dbReference type="STRING" id="75743.A0A401QDY3"/>
    <dbReference type="OMA" id="LMFRSER"/>
    <dbReference type="OrthoDB" id="90756at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="189" mass="23242" checksum="7C834E8BEBCDBFB0" modified="2019-05-08" version="1">MFRSEPSLMFRSELSLMFRSKRSLMFRSEQLLMFRSELSGVFSSLLFRSECSGVMFRSERSLMVRSARSLMFRSERSLMFRNERPLMFRSELSLMFRSELSLMFRIERSLMFRSERSLMFRSEGSLMFRTERSLMFRSERSLMFRSELSLMFRSERSLMFRSERSLMFRSERSLMFRRERSRMFRSERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QEL3</accession>
    <name>A0A401QEL3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C19 ubiquitin carboxyl-terminal hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01043408">
        <property type="protein sequence ID" value="GCB83811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QEL3"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="55" mass="6694" checksum="ED917F29B976DD16" modified="2019-05-08" version="1" fragment="single">PRRAQLQRLQQDAQEFLRFLMDWLHIEINRKTRKTPNIMSLSGNRMSADNLERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QER8</accession>
    <name>A0A401QER8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01057562">
        <property type="protein sequence ID" value="GCB83885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QER8"/>
    <dbReference type="STRING" id="75743.A0A401QER8"/>
    <dbReference type="OMA" id="YPDRQCV"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="260" mass="31407" checksum="45E7AFBFDBBE492F" modified="2019-05-08" version="1" fragment="single">LRYPDRQCVPDPCYTDRQCVPDPRYPDRQCVPDPRYPDRQCVPDLRYPARQCVPDLRYPDRQCVPDPRYPDRQCVPDHRYPDRQCVPDLRYPDRQCVPDHCYPDRQCVPDPRYPDRQCVPDPHYPDRQCVPDLHEPDRQCVPDLRYPDRQCVPDLRYPDRQCVQDLRCPDRQCVPDLRYPDRQCVPDLRYPDRQCVPDLRYPDRQCVPDLRYPDRQCVPDLHYPDRQCVPDLLYPDRQCVPDLRYPDRQSVPDLHDPDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF44</accession>
    <name>A0A401QF44_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01052829">
        <property type="protein sequence ID" value="GCB84000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF44"/>
    <dbReference type="OrthoDB" id="10539767at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="78" mass="9159" checksum="5DD26D6A3716CCD8" modified="2019-05-08" version="1" fragment="single">KGSEALRLHVKEQFSQMHRFLSEKEDSLSRELTEHENSVLELIRENLRRAEEGLRSLDARLKRLNGQQAQGDDIQFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGI2</accession>
    <name>A0A401QGI2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01072971">
        <property type="protein sequence ID" value="GCB84494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGI2"/>
    <dbReference type="STRING" id="75743.A0A401QGI2"/>
    <dbReference type="OMA" id="CRIAWRM"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8179" checksum="F8F2FCD038360177" modified="2019-05-08" version="1" fragment="single">KNLENPEVAAEKFKLIQAAYDVLSDPQERAWYDSHREAILKGGLNGDYEDESVDLLQYFTTACYSAFGDDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIL1</accession>
    <name>A0A401QIL1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="CPDCTFG"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="386" mass="39873" checksum="39810DA86FFDC635" modified="2019-05-08" version="1" fragment="single">ENNDGKDGDEDNDDDDNGDEDNDDNGDVNGDEDGDEDNDDDGDGDVNGDQDNDDDGDVNGDEDGGEDNDDDGDEDDDDYGAQNDVNEGNGDDGDEDDDSEGNGDGDEDDDSDEDDSEGIGDDDEDDDSDEDDSEGNGDGDDSEGNGDGDEDDDSDGDDSEGNDDGNEDNDSDEADRDGDEDDDSDEDDSEGDDSEGNGDGDEDDDSDEDDSEGNGDGDEDDDSDGDDSEDNGDGDEDNDSDEAGDNDEDEDSDEDDDSGEDNDSGEDNDSGEDDVSDGDEDGDSEGNGDEDDDGDGDGDGDGDEDDSEGNGDGDEDDDSEGNGDGDGDSDGDEDDDSDGDGDEDDDSEGNGDGDEDDESDGDEAGDSEDNGDEDDESEGNGDKTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKA4</accession>
    <name>A0A401QKA4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0026459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB85794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
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            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018984456" evidence="2">
        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB85794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="191" mass="21378" checksum="B98EE4EA8BF82A9D" modified="2019-05-08" version="1" fragment="single">VHPRSPRKQPSRYLLHQRWAVHLVLLLLCNGDPQDKGVNRTRDCRDEDNGRQLERESDEEREGKESLPAHTVTGLMGAGEVQAEIGEDLGSDEDPEGVWNHLLGDSIWEKAKPTQDKEDEMSSQSDCSHQEQGQLVAGVEHGTCQDDVTVEESRKYHQHQQSLVPLPTEVGLVQILQGLRDKGQSHEPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL70</accession>
    <name>A0A401QL70_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01246750">
        <property type="protein sequence ID" value="GCB86120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL70"/>
    <dbReference type="STRING" id="75743.A0A401QL70"/>
    <dbReference type="OMA" id="NHHDTNH"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF14">
        <property type="entry name" value="EXPORTED REPETITIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="313" mass="38311" checksum="37318228EE014262" modified="2019-05-08" version="1">MTLNAMTLNSHDPEHHDHDHHDPEHHDPEHHDPEHRDPDHHDPERHDHDHHDPEHHDPERHDPDHHDPEHHDPEHRDPEHRDPEHHDPEHHDPEHHDPEHHDPEHHNPERHDPEHHNPERHDPEHHNPEHHDPDHHDPGHHDPEHHDPEHHDPDHHDPEYHEPEHRGPEHRDPELQDPEHHDPELQDPEHRDPEHHDPEHHDPERHDPEHHDLELQDPEHHDPELQDPEHHDPERHDHERHDPERHDPEHHDPELQDPEHHDPERHDPEHHDPDHHDPGHHDPEHRGPEHHDPEHHDPEHHDPEHHDPELHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLN9</accession>
    <name>A0A401QLN9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01278071">
        <property type="protein sequence ID" value="GCB86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLN9"/>
    <dbReference type="OMA" id="TWIWTET"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="217" mass="24823" checksum="F73873AB38F88616" modified="2019-05-08" version="1" fragment="single">SDTDTDRESDTDTGTDTDSDTDTDSDRDSDRDRGSDRDSDIDRDTGTGSDTDTDSNRDSDRDSDIDRDSDIDRDTDRDTDRDSDIDRDSDIEKYIDRDTDSDRDTDSDRDSDRDRDIDRGSDIDRDSDRDRDTDRDTGTDTDTDTDTETDTDTDRDTGSDSDRETDTDRDTDSDRDTDTDSDRDRDSDRDSDRDSDRDSDRNTDTDRDTDTDSDRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM12</accession>
    <name>A0A401QM12_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
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        <lineage>
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            <taxon>Elasmobranchii</taxon>
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            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01296830">
        <property type="protein sequence ID" value="GCB86467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM12"/>
    <dbReference type="STRING" id="75743.A0A401QM12"/>
    <dbReference type="OMA" id="NQNERGV"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF3">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="274" mass="27745" checksum="B7271C50A358B1D1" modified="2019-05-08" version="1" fragment="single">MCGWDESQSVCDCDEANQCAAGMKANQCVAGLKANQCVDGLKANQCVTGMKADQSVTGLKANQCVTGMKANQCAAGMKANQCVAGMKANQCAAGMKANQCVAGMKANQCVTGMKANRCVTGMKANRCVTGMKANQCAAGMKANQCAAGLKANQCVTGMKANQCAAGMKVNQCATGMKANQCLTGMEANQCAAGMKANQCVTGLKAHQCAAGLKANQCVAGLKANQCVTGMKANQCVAGLKANQCVAGLKANQCVTGMKANQCVTGLKANQCVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NG71</accession>
    <name>A0A401NG71_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004882">
        <property type="protein sequence ID" value="GCB59920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NG71"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB59920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="135" mass="15022" checksum="DF8601E0C124B886" modified="2019-05-08" version="1">MLQRQAEHIGLSLGEGYYEELTTMTNPSANCLTHAWLARWLIRQIIHLREGGRVEALLLAVMLFASGTTGYVCDVSAKADDGIMVGVGRKRPTTLRELFEQALALEAAACDWENRWSGYCTGLVQEDELPQEGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHD8</accession>
    <name>A0A401NHD8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006224">
        <property type="protein sequence ID" value="GCB60283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHD8"/>
    <dbReference type="STRING" id="75743.A0A401NHD8"/>
    <dbReference type="OMA" id="NCKSLFH"/>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06723">
        <property type="entry name" value="PDZ1_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06724">
        <property type="entry name" value="PDZ2_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000049">
        <property type="entry name" value="disks large homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000002">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019583">
        <property type="entry name" value="DLG1-4_PDZ_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019590">
        <property type="entry name" value="DLG1_PEST_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF5">
        <property type="entry name" value="DISKS LARGE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10608">
        <property type="entry name" value="MAGUK_N_PEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10600">
        <property type="entry name" value="PDZ_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01277">
        <property type="entry name" value="MAGUK_N_PEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="221"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB60283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="332" mass="35807" checksum="0D63E7908A8B44F9" modified="2019-05-08" version="1" fragment="single">TVSLMFGCKKYRYQDDDTSPQEHNSPQISNEVKGPELVHVSEKNLSQIENIHGFVSQSHISPMKIEATPPSTPVIPVIPVMPVPADASVFSSDSQQANPPPVVVNADSLESQPYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIAGGAAAQDGRLRVNDCILRVNDVDVRDVTHSKAVEALKEAGSIVRLYVRRRKPITEKILEIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNTASLDEVSHEDAVTALKNTAEVVYLKVAKPTSMYMNDGYAPPDITNCKSLFHLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIC8</accession>
    <name>A0A401NIC8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stimulator of interferon genes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0012774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the STING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006277">
        <property type="protein sequence ID" value="GCB60619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIC8"/>
    <dbReference type="STRING" id="75743.A0A401NIC8"/>
    <dbReference type="OMA" id="CRTLENI"/>
    <dbReference type="OrthoDB" id="6053839at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061507">
        <property type="term" value="F:2',3'-cyclic GMP-AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22658">
        <property type="entry name" value="STING_C_metazoan-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12100:FF:000001">
        <property type="entry name" value="Stimulator of interferon genes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12100">
        <property type="entry name" value="Stimulator of interferon genes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029158">
        <property type="entry name" value="STING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047191">
        <property type="entry name" value="STING_C_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038623">
        <property type="entry name" value="STING_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055432">
        <property type="entry name" value="STING_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339:SF1">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15009">
        <property type="entry name" value="STING_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STING ligand-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="202" mass="23588" checksum="A24DF5B82DA9161A" modified="2019-05-08" version="1" fragment="single">LEERMKEYQCSVKYVPDCKENWKLYILIPFNCKIYDKLEKVDSRIQFFGNLPELCIDRAGIKGRSYKNSIYAVKDQWERPHHCILEYATPLRSLFEMSNDATAAFSKEQRLEQAKLFYITLENILNNSQECAGYFKLIPYGDDLEEGNMGSEFLSTKILQHLAQERMEYTVPEQSTWDATLSEDQLMISGSEDPQTLQSINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIX5</accession>
    <name>A0A401NIX5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0006943</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01002428">
        <property type="protein sequence ID" value="GCB60824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIX5"/>
    <dbReference type="STRING" id="75743.A0A401NIX5"/>
    <dbReference type="OMA" id="WLPEQNG"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000016">
        <property type="entry name" value="Arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000002">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000084">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="15">
        <location>
            <begin position="67"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="14">
        <location>
            <begin position="523"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB60824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="649" mass="74028" checksum="C841EF7958D4FACB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ18</accession>
    <name>A0A401NJ18_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0014241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007573">
        <property type="protein sequence ID" value="GCB60870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ18"/>
    <dbReference type="STRING" id="75743.A0A401NJ18"/>
    <dbReference type="OMA" id="TPESTIW"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001617">
        <property type="entry name" value="WD40-repeat-containing domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB60870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="475" mass="52895" checksum="792945AF545675DB" modified="2019-05-08" version="1" fragment="single">VTLTQQELKELIHNAREEFDDQEEGEEQAVDRNEEELMDGTDNPASRDSKTLEDGEEEEDKDSLAEYDLDRYDEEEGGVNLGDSLGGLTVYASNEDDPYVTLKNTDHYEDEDFKIKPTDNLIVVGKAEKDCCSLEIYVHNQEEQSLYVHHDVLLPAYPLCVEWLNFDPNPEALTGNYAAVGNMTPVIDVWNLDVVDCLEPVFSLGIKKAKKKKQGRKGAASAEKGEDGHTDAVLDLSWNRHIRTVLASASADKSVILWDMSQKKPVTQLSSHTDKVQTLCWHPFEAQTLLSGSFDKSVILYDCRSPKESHRSWRFSGEIERVTWNHFSPCNFLASTEDGFVYCLDARSDKPLFTLKAHDGEVTGLELSSEIQGCLVTSSSDKHVKIWDILGNKPSLVHSRDMKMGVVFCGACCPDLPFVYCFGGQKGGLRMWDISTVSAVNVAFGSRERLQVAAPWSSSVTGPVTSSTTQNAMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NL92</accession>
    <name>A0A401NL92_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proline-rich membrane anchor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007682">
        <property type="protein sequence ID" value="GCB61646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NL92"/>
    <dbReference type="OrthoDB" id="8885320at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029659">
        <property type="entry name" value="PRIMA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16101">
        <property type="entry name" value="PRIMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12582" checksum="224091EB967EC849" modified="2019-05-08" version="1">MAHTVSDAEITKSAANPQKPKDIEKDSGEGFSAEEKIPAVKPTEYPPLKPWWTDMVILIAVGCATLVFLVIAVIICYKAIKRKPMRKEENGTSRAEYAMTSQNDKMPDTNSAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNN2</accession>
    <name>A0A401NNN2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006535">
        <property type="protein sequence ID" value="GCB62462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNN2"/>
    <dbReference type="STRING" id="75743.A0A401NNN2"/>
    <dbReference type="OMA" id="FREEMWN"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="24710" checksum="F72B7983D74EB82B" modified="2019-05-08" version="1">MGQNMNSMEQNMHSMKQNMHSIEQNMHSMEQKVLHGAQHAFHGAEHAFHGAEHAFHGAEHAFHGEEHVFHGEEHAFHGAEHAFHGAEHAFHGAEHAFHGAEHAFHGEEHVFHGEEHAFHGEEHVFHGEEHVFHGEEHAFHGAEHKHAFHGEEHAFHGAEHAFHGAEHAFHGAEHAFHGEEHVFHGEVHAFHGEEHVFHGEEHVFHGEEHAFHGAEHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP63</accession>
    <name>A0A401NP63_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003921">
        <property type="protein sequence ID" value="GCB62627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP63"/>
    <dbReference type="OrthoDB" id="10393942at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB62627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="414" mass="46184" checksum="A908260164C476BB" modified="2019-05-08" version="1">MRRIQRGKTPQIDPDYHAGSNCTTVGRHPVPLQHRSTQRRLGSETIIWKSVSDATMRRCVDYKLTINQVSKLDAYLLPRAEAEKPLPFKVNLVHNTQEVSLIGGRVPYIKELTEQEVFTRKLFGLSNPMITNGGSEMGMNEDTQVSMDTSDGDGGELAAASEIPERADEERTEVNTSQQCGMAAAVEEGEECQEVKMSDLEGSVDELKLNIVVCVKKEACDDPAAVVEGGRSEPSGSEEPLALGAESPPSPRAHGQHKAHVPGEETEDYLKPLERLHQEQVQSTDSYRVTSNLFQQTLTEFKTDIRQNLQRNKEILQQQNEVLRQQNEIRNQHLQRNNEILQQQNEVLRQQNEALCQLLQRSNETLNEMSKILSRTVVPAPSGQTQPSAETSAAGHPSGTGEITPWGLGRHRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPD1</accession>
    <name>A0A401NPD1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine and glycine-rich protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteine-rich protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0013102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006561">
        <property type="protein sequence ID" value="GCB62702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPD1"/>
    <dbReference type="STRING" id="75743.A0A401NPD1"/>
    <dbReference type="OMA" id="CKTDYDR"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF3">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB62702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="21402" checksum="06B19780B61C1D1C" modified="2019-05-08" version="1" fragment="single">SRMSHWGGGNKCGSCQRTVYHAEEVQCDGKSYHRCCFLRMVCRKGLDSTTMAVHGKEIYCQSCYGKKYGPKGYGYGQGAGTLSMDRGERLGIIVQNAQPHRPTTNVNTSKFAQKFEGVDKCSRCGDSVYAAEKIIGAGKPWHKNCFQCEKCRKSLESTTMTEKEGEIYCKSCYAKNFGPKGSGFGQGAGGLVHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPF1</accession>
    <name>A0A401NPF1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001268">
        <property type="protein sequence ID" value="GCB62778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPF1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB62778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="11409" checksum="F8F154992E216C63" modified="2019-05-08" version="1">MVCGLSCCTRQFGTPPAFKSHPAPVIGLSRLSCAEWLRTCFNRWLGLVCVITSEWGLERKGCTVGTVWSCESTLRVESRSFQEDLLGKKEYNLSDSLIGDSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRK7</accession>
    <name>A0A401NRK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005357">
        <property type="protein sequence ID" value="GCB63538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRK7"/>
    <dbReference type="STRING" id="75743.A0A401NRK7"/>
    <dbReference type="OMA" id="QMSRHSK"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="71"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB63538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="326" mass="36353" checksum="13EDC70D124D658B" modified="2019-05-08" version="1">MWCHDFIGEFTTNYRELSRGQSQFNVYEVLNPKKKAKKKKYINSGTVTLLSFAVHTECTFLDYIRGGTQINFTVAIDFTASNGHPAQPTSLHYMNPYQLNTYAMALKAVGEIIQDYDSDKMFPALGFGAKLPPDGRISHEFALNGNPHNPYCQGIEGVMEAYYQSLKSVQLYGPTNFAPVINHVARYAASVKDGSQYFILLILTDGVISDMAQAKESIVNASCLPMSIIIVGVGPAEFDAMEELDGDEIRISSRGRYAERDIVQFVPFRDYVDRTGNHVLSMARLAKDVLAEVPEQFLSYMKSRGIKPSPAPPPYTPPGYPFQTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS46</accession>
    <name>A0A401NS46_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005376">
        <property type="protein sequence ID" value="GCB63695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS46"/>
    <dbReference type="OMA" id="IAKNDQH"/>
    <dbReference type="OrthoDB" id="8962799at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36912:SF2">
        <property type="entry name" value="ANTIGEN 332, DBL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36912">
        <property type="entry name" value="ANTIGEN 332, DBL-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="374" mass="39901" checksum="C9B2D9EAABE3D613" modified="2019-05-08" version="1">MHGSIQGIFHPLKETLSVQHKRNQREVTRHFVVFISSETPNKKPSDSTDDIVSPVDSTDTIVPLVDSTDDIVPTIDSADDIVSPVDSTDNIVTPVDSTGDIVSPLDSTDNIVSPVDSTDNIVTPVDSTDNIVLPVDSTANIVSPVDSTDKIVLPVDSINDIVSPVDITDNIVSLVDSTDNIVLPVDSTVNIVLPVDSINDIVPPADITDNIVLPVDSTDNIVSPVDCTDTTVLPVDSINDIVSPVDSTDNIVSPVDSTDNIVLPVDSTDNIVSPVDSTDNIVSPVDSTDNIVLPVDSINDIVSLVDSTDNIVLPVDSTDNIVLPVDSTDNIVNHTPKLGPKASSPFHNADELRDYRSPPSYIAKNDQHLHPQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSY8</accession>
    <name>A0A401NSY8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endophilin-A3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0009755</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the endophilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004064">
        <property type="protein sequence ID" value="GCB64013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSY8"/>
    <dbReference type="STRING" id="75743.A0A401NSY8"/>
    <dbReference type="OMA" id="ETALDYH"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07592">
        <property type="entry name" value="BAR_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000053">
        <property type="entry name" value="endophilin-A1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000021">
        <property type="entry name" value="Endophilin-A2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF45">
        <property type="entry name" value="ENDOPHILIN-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="14">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="291"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB64013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39783" checksum="1BA1781E42ECFC1F" modified="2019-05-08" version="1">MSVAGLKKQFHKASQFVSEKMGGAEGTKLDEDFVEMERKIEATSKAVAEVLSKTTEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQPEGLLGECMLRNGKDLGDDSNFGPALVDVGEALKQMGEVKDSLDIDVKQNFIDPLQILQEKDLKEIGHHLKKLEGRRLDYDYKKKRHGKIPDEEIRQAVDKFEESKELAEISMFNFLENDVEQISQLLALVEAALNYHKESTTILEELHNTLQHRINTASNRPKRDFKPKPVVVTSFEPSDNQQQNGLSYSSSFKSSAPCTQVDQPCCKALYDFDPENEGELGFKDGDIITLTNQIDENWFEGMLNGESGFFPINYVQVIVPLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUW6</accession>
    <name>A0A401NUW6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000059">
        <property type="protein sequence ID" value="GCB64676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUW6"/>
    <dbReference type="STRING" id="75743.A0A401NUW6"/>
    <dbReference type="OMA" id="MEEDNSQ"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47059">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47059:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="99" mass="11811" checksum="98A9A4B6CC0B4DC0" modified="2019-05-08" version="1">MCKCCAEDLANAYNNRGQIKYLRVDFYEAMDDYTLAIQNKEDFEVPYYNRGLIHYRLGCFDQALEDFKRTLTLNPDFKDARLSLEQTLIDKNEKEFRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NV08</accession>
    <name>A0A401NV08_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0013374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006800">
        <property type="protein sequence ID" value="GCB64705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NV08"/>
    <dbReference type="STRING" id="75743.A0A401NV08"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB64705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="302" mass="34259" checksum="3F420BEF796B74F6" modified="2019-05-08" version="1">MQSAALNRQSDFNDAPDGLEGSFFIDMINEGTEQRNTKIEEEIANHLGNWMIPLIINQTITYIKLDTGARANLINEADLLMTWIKPRIEDNDCNLTDYHGAPIKTLGTFNLQIKVNAKLFTEIKQLTIQNEELNRKTGDVETCLQEKKAELQVMTDNLGDINEQQLSAMNSTLKQLEEKLKGQSDYEDFNKELSILKLMEGEASVGSGSQGTTKTIEILQLEKNRSLQSENETVRITNSDLSDPVPALESGQQLQLQVQHMQDGETENQKLRDTLEEYNKEFPEVKNQEGTIKALKERNQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVY4</accession>
    <name>A0A401NVY4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-related GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0007631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002808">
        <property type="protein sequence ID" value="GCB65046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVY4"/>
    <dbReference type="STRING" id="75743.A0A401NVY4"/>
    <dbReference type="OMA" id="HEIFEVR"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000001">
        <property type="entry name" value="Ras-related GTP-binding protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000226">
        <property type="entry name" value="Ras-related GTP-binding protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF5">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB65046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="397" mass="45080" checksum="2F23A86B72483494" modified="2019-05-08" version="1">MSELAAAEAEEEEGSECGFIGLEFAYGGETECEVDGDPDNPAAAGGVMHFSDDYWTEVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKICRDDIANSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGTGALIFVVDSQDDYMEALARLHLTVSRAYKVNKEINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEQIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSVPVDMQTYELCCDMIDVVFDISCIYGLREFGGGNTYDKESVAIIKLNNTTVLYLKEVTKFLGLVCFLREESFERKGLIDYNFHCFRKAIHEIFEVRTTVLKCRKQHRGLQRSKLGTPNGTLGPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0K5</accession>
    <name>A0A401P0K5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0013604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Late endosome membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Lysosome membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007023">
        <property type="protein sequence ID" value="GCB66665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0K5"/>
    <dbReference type="STRING" id="75743.A0A401P0K5"/>
    <dbReference type="OMA" id="LMTMEFK"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000164">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000570">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="398"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="558"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="768"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB66665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="827" mass="95378" checksum="384DDD6F02E2F02F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1D4</accession>
    <name>A0A401P1D4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sm protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0010170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004332">
        <property type="protein sequence ID" value="GCB66939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1D4"/>
    <dbReference type="STRING" id="75743.A0A401P1D4"/>
    <dbReference type="OMA" id="IIMLERV"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB66939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="82" mass="8961" checksum="3CDA0F1DEA0B00EB" modified="2019-05-08" version="1">MAGVVQHVRSAPARAKEVHGQETVTKLNGGRHVQGIPRGFDPFMILVVDESVEMAPGIQQNNIGMVVIRGNSFIMLEPLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2P2</accession>
    <name>A0A401P2P2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 122</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007103">
        <property type="protein sequence ID" value="GCB67404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2P2"/>
    <dbReference type="OMA" id="FMTELYE"/>
    <dbReference type="OrthoDB" id="9881749at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB67404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="27189" checksum="0707B7195B59F40B" modified="2019-05-08" version="1">MYFERKAQLFELEKEKKTILQEIRTTEKQIYHLENESESRQQHCADLEAQLWSLNANNLQLKFAIQEEEEKYFKFLAEYDKYRKKMLGHKELTNQLESRSPIVMQLEEKILMVKELKAKKEELAADLMNPEGNIIKQVQGEITELKTKISEIREAINEKSVLLIKEEERHVQLRKEIEVQNKRCEAILKRLYCQLNKVQSNKRQFTWDIQHMEKTAAHLRRCLGITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P426</accession>
    <name>A0A401P426_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0010315</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family. Class-6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004418">
        <property type="protein sequence ID" value="GCB67873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P426"/>
    <dbReference type="STRING" id="75743.A0A401P426"/>
    <dbReference type="OMA" id="RFEQSSH"/>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000051">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000013">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF68">
        <property type="entry name" value="POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="13">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB67873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="195" mass="22005" checksum="7B4189BE343660A0" modified="2019-05-08" version="1">MDNVTGGNPQTATSEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQPEPSTGLPMEPLTDSFEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P644</accession>
    <name>A0A401P644_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrin alpha-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008546">
        <property type="protein sequence ID" value="GCB68609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P644"/>
    <dbReference type="STRING" id="75743.A0A401P644"/>
    <dbReference type="OMA" id="GPRYEYN"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF69">
        <property type="entry name" value="INTEGRIN ALPHA-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="FG-GAP" evidence="1">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="1">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20680" checksum="B89B58309455042F" modified="2019-05-08" version="1">MDGLLGEDMKLLKFCVALIWFGLMVHSYNIDLDHPVVFRGTNGTFFGYSVLEHFHDNTRWILVGAPQANSTYSSSVLSPGALYKCRIHSNPEKRCTELDLGRGDQRGKTCGKTCKENRDNEWMGVSLSRQAGGNGSVLACAHRWKNIHYQSEHILPHGACYIIPPNLSRRTKELLPCYQGKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6E7</accession>
    <name>A0A401P6E7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fibroblast growth factor</fullName>
            <shortName evidence="12">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0008258</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003126">
        <property type="protein sequence ID" value="GCB68650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6E7"/>
    <dbReference type="STRING" id="75743.A0A401P6E7"/>
    <dbReference type="OMA" id="NHYNTYL"/>
    <dbReference type="OrthoDB" id="5987799at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000020">
        <property type="entry name" value="Fibroblast growth factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="7" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="11" id="KW-0497">Mitogen</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB68650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="20579" checksum="E86CA5AC48701093" modified="2019-05-08" version="1">MFELHIPNVPGFRERSKDPYEHWAGRNMDAGTVTSLSSLSNSFNHFLGSYKDPKLLYCANGGYFVRIRPDGQVEGTRDRSDVYIQLQLQAVSRGVVTIQGIEARCYLAMSEVGQLHALPAPTDECFFLETLEENGYSTYKSKEYMERNWYVAIRKNGNAKPGPRTNVGQKAILFLPMQVTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6H2</accession>
    <name>A0A401P6H2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007252">
        <property type="protein sequence ID" value="GCB68703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6H2"/>
    <dbReference type="OMA" id="QGYQINE"/>
    <dbReference type="OrthoDB" id="2155246at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="32"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="194" mass="21712" checksum="39A82863663F53AC" modified="2019-05-08" version="1">MTQGPVAAVTGPITFGEEGRSTKGIEINKMACSIDRPLEGNSFGIHYVTGDLFNCPEQDALAHCISEDCRMGAGIAVLFRKRFQSVTELLNQKKKTGDVAVLKRKQRYIYYLITKKKAYQKPTYDSLQSSLEAMKRHCLNNGVTRISMPRIGCGLDKLNWSIVSARIQEVFKGTNIEITVYSLETPTKFISHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7S2</accession>
    <name>A0A401P7S2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005967">
        <property type="protein sequence ID" value="GCB69201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7S2"/>
    <dbReference type="STRING" id="75743.A0A401P7S2"/>
    <dbReference type="OMA" id="MYIIEPL"/>
    <dbReference type="OrthoDB" id="9950504at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF13">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019308169" description="Peptidase M12B propeptide domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B propeptide" evidence="3">
        <location>
            <begin position="79"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="185" mass="20725" checksum="8874AFAF4BA31EFC" modified="2019-05-08" version="1" fragment="single">MNLPGRCCFLSLLLLCSSLQPFGAAVLQLSGADGEPLAAGTTATLNHSSDTPQQEIAWPLRLIYYVHDDNESTYHVLDTKARDQQKHHQAVHLTHASFQIDAFGSTFILDVTLNHNLLSSEYKEIHYEKQKKFFSKGGEHCYYHGQIRGIARSKVALSTCDGLHGMFDDGNYMYIIEPLAQTHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P839</accession>
    <name>A0A401P839_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003180">
        <property type="protein sequence ID" value="GCB69274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P839"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8118" checksum="FEF00C34823187A1" modified="2019-05-08" version="1">MPECGVVGCLIDKGADHPRAGQSAAPIETEESETQIPEKSPSEIIAAESASTVEQQPVELPDCQKKRKSPDRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8H7</accession>
    <name>A0A401P8H7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0005463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GCB69380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401P8H7"/>
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    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RING-HC_RNF219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039209">
        <property type="entry name" value="OBI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035691">
        <property type="entry name" value="OBI1_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14609:SF1">
        <property type="entry name" value="ORC UBIQUITIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14609">
        <property type="entry name" value="RING FINGER PROTEIN 219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
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            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
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        <location>
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    <feature type="coiled-coil region" evidence="5">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB69380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="726" mass="81532" checksum="58C772E701FC0694" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8R0</accession>
    <name>A0A401P8R0_SCYTO</name>
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        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 299</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0001071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000227">
        <property type="protein sequence ID" value="GCB69535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="DUF4464"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588:SF1">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
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            <dbReference type="EMBL" id="GCB69535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8428" checksum="46F64059D3E1E543" modified="2019-05-08" version="1">MQQIVKITVNVLTLSIIFIRDYNSHGQEISGYIDYSHRLKTEQFEGYFGGKKKLMPRSTDLRIFFPPCCLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB17</accession>
    <name>A0A401PB17_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004694">
        <property type="protein sequence ID" value="GCB70310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401PB17"/>
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    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="339" mass="37212" checksum="0CED923E83ADD3E6" modified="2019-05-08" version="1" fragment="single">SYDSDGWCPPPPVKSYLHQGMEDELEEEDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDEISRAYHFDISRQMQGSSLPPQAPALPLGYISGTLISDIETDLPDEEEEEEDEDALEMARPLRGIAHTPGSSLDNLDSSVTGSMINGWGSASEEERNMSSRRSSAVSSSSDSIFTDGDFAQALATAADRAGFRMEGTSLMRTGKGYSSSQRLQPSSPFSSNGSVSAAHNQCQRSRPPKKHKTAGGRQEQPPAPHRREAAADVFRGCIVVKERVPEIVQNEPSLPDTMTLKWCNETPPYLMYYDRTCKCDVKFRKHSHRVSIPTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBC1</accession>
    <name>A0A401PBC1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0001274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000279">
        <property type="protein sequence ID" value="GCB70418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBC1"/>
    <dbReference type="STRING" id="75743.A0A401PBC1"/>
    <dbReference type="OMA" id="TRGMESY"/>
    <dbReference type="OrthoDB" id="6081310at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048384">
        <property type="term" value="P:retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002154">
        <property type="term" value="P:thyroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06935">
        <property type="entry name" value="NR_LBD_TR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000006">
        <property type="entry name" value="Thyroid hormone receptor beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF42">
        <property type="entry name" value="THYROID HORMONE RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="10">
        <location>
            <begin position="97"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB70418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="344" mass="38916" checksum="A9E3CE69052F39A8" modified="2019-05-08" version="1">MWNFIGLAFNSKEQGKASIGSPAAEWDPPNASIKSNPVPVLNNDNKATAKTSYTNPILVLDDSKRIAKRKLIEENRVKRRREEVVKTMQNRPEPTSEEWELIRVATDAHVTTNAQGSHWKQKRKFLPEDIGQSPMATTSEGDKVDLEAFSQFTRIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDAESETLTLNGEMAVKREQLKNGGLGVVSDAIFELGKALSAFNLDDTEVALLQAVLLMSSDRTGLTCIDKIEKCQEAYLLAFEHYINYRKHDIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBJ4</accession>
    <name>A0A401PBJ4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003324">
        <property type="protein sequence ID" value="GCB70485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBJ4"/>
    <dbReference type="OrthoDB" id="9448246at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="159" mass="17738" checksum="2A2B7890B62DFDDC" modified="2019-05-08" version="1" fragment="single">AFEEDSPSDAVEQTPHERQSVIAPSPKQSSVKAITVTAEFALVSQSESLFSISGNNNLQASHQASFKVEQQEVKIPILSRSRSSLSHQEDIVPNPNTWKQSAFLQARPLASVLMVEQNRSSFTGEGQKICPTQQRDQNYDYALEEIFIIIKSTKRYIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC08</accession>
    <name>A0A401PC08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0005738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001833">
        <property type="protein sequence ID" value="GCB70658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC08"/>
    <dbReference type="STRING" id="75743.A0A401PC08"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB70658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="11744" checksum="8E6300B1834ACD6E" modified="2019-05-08" version="1">MTARGTASRFLQSVLHNGVGRYICQLKRLSLVFSKNAPSSRGVREFIEEGVVDFAKQNPGIVVYVTAKRCNVPKLVAEYREYCLPLRETWNNRFVQSTERYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCD1</accession>
    <name>A0A401PCD1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0005769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001848">
        <property type="protein sequence ID" value="GCB70768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PCD1"/>
    <dbReference type="OMA" id="WNIDEAV"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000727">
        <property type="entry name" value="NACHT and WD repeat domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF39">
        <property type="entry name" value="NACHT AND WD REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="381"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="4">
        <location>
            <begin position="607"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB70768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1713" mass="194552" checksum="C3E869A7976C2712" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD57</accession>
    <name>A0A401PD57_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001876">
        <property type="protein sequence ID" value="GCB71052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD57"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="122" mass="13631" checksum="FEBBE8A43CA27CAF" modified="2019-05-08" version="1">MVRVQGKDLNRRVDHLRSRMEQVPEDRPRILGPVVPLAPEQLPVVPSEATGPSDFKIWEIDQSDQESDMKRLPMDVDAVQLLPVTGENVSLAGVTLVPEEAKFTFKPDSDVCVKVEILMDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDP5</accession>
    <name>A0A401PDP5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0008788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003430">
        <property type="protein sequence ID" value="GCB71229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDP5"/>
    <dbReference type="OMA" id="GEMEQHL"/>
    <dbReference type="OrthoDB" id="8943917at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032757">
        <property type="term" value="P:positive regulation of interleukin-8 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032675">
        <property type="term" value="P:regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030113">
        <property type="entry name" value="AFAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338:SF4">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB71229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="108" mass="11903" checksum="3F8D76C2B8342B91" modified="2019-05-08" version="1" fragment="single">MDRSKALDQLLAELETFLKLLDNENLSLSALAKKCVLSDLLHNIISSSAGEEEYIYMNKVLLGETTATEKKALEKGLDHGDIPNGIEFRKITPAPQKSLPQLPPTKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFG6</accession>
    <name>A0A401PFG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Armadillo repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000402">
        <property type="protein sequence ID" value="GCB71890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFG6"/>
    <dbReference type="STRING" id="75743.A0A401PFG6"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043379">
        <property type="entry name" value="ANKAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464:SF1">
        <property type="entry name" value="ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24759" checksum="CD6B44C3BFBBF1A2" modified="2019-05-08" version="1">MMGSNEYKKQEMGVRSLEILCVVKKHYWKAINSSGSIPALINLLRSKHETLQCISAAVLCNLSTYLPVCHSIITYDIIPVLIGLLHSQQPELQSRCAVILCDIAQIEDNASQIASLDICLRAASALALFVFNNPNQEHLIREAGGIEMSVFQNLLQSSKEVNQANAAFQMIMLAKVIIDKDDVTLSATGIMTLVNLLKSGKSSTVIVVVHYCTAQSTFQLIAVQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGS0</accession>
    <name>A0A401PGS0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat and SOCS box protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0006254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with CUL5 and RNF7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002076">
        <property type="protein sequence ID" value="GCB72330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGS0"/>
    <dbReference type="STRING" id="75743.A0A401PGS0"/>
    <dbReference type="OMA" id="DYNCTDR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000096">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="10">
        <location>
            <begin position="268"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB72330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="320" mass="35815" checksum="26C91151596BD666" modified="2019-05-08" version="1">MELEIMWPVKMSLVDITKIFSMFQPKDEDDNGERSQLNQAISKDDDKLLGELLSQERYIKFINSRSGWGVPGTPLRLAATRGHLKCLEVLLAHGAEVDSLDVKAQTPLFTAVSGRHLDCVQALLRAGANPNGSKYNNSSPILIAAREGEVEILKELLEHGAEVNVRSKMPDWVSNPCACSGPLYLSLVYGHFDCFRLLLLNGANPDFNCTEERLLARIKTPKSALEMCFRYGCGTEYVQLLIDFGANLCLPDLSVDKNIKQKEVFKLLTRARAQPRCLMSLSRITIRKYLKQGSGLHSIDCLDIPPILKNYVNHQISVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHF4</accession>
    <name>A0A401PHF4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AT-rich interactive domain-containing protein 3</fullName>
            <shortName evidence="7">ARID domain-containing protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0002048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000490">
        <property type="protein sequence ID" value="GCB72538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHF4"/>
    <dbReference type="STRING" id="75743.A0A401PHF4"/>
    <dbReference type="OMA" id="HIHKIKK"/>
    <dbReference type="OrthoDB" id="10044343at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16878">
        <property type="entry name" value="ARID_ARID3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000006">
        <property type="entry name" value="AT-rich interactive domain-containing protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045147">
        <property type="entry name" value="ARI3A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023334">
        <property type="entry name" value="REKLES_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348:SF1">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51486">
        <property type="entry name" value="REKLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="9">
        <location>
            <begin position="240"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="REKLES" evidence="10">
        <location>
            <begin position="440"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB72538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="574" mass="63492" checksum="1E96C7441F002F33" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHQ8</accession>
    <name>A0A401PHQ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Growth factor receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0002120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000509">
        <property type="protein sequence ID" value="GCB72666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHQ8"/>
    <dbReference type="STRING" id="75743.A0A401PHQ8"/>
    <dbReference type="OMA" id="ANDCITC"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15332">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15332:SF175">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20692" checksum="4C9DD2AAA4047553" modified="2019-05-08" version="1">MGDLSGHRGDEYIDNAGECHTCHVFCDRCYGPSDVECITCSTPRFYDSGYCATNCPTGKFDMNGQCYSCHHTCKECTGSEPNNCTSCDQDKFRNDRYLFNSVCREDCPTSHYPAAGNICLPCSSNCEVCTSDTHCVKCSSGYYPNPEGCQQLKCEEGEIADPDYEDCIQCGEGCEKCILGELLHRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHX9</accession>
    <name>A0A401PHX9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0002160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000523">
        <property type="protein sequence ID" value="GCB72745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHX9"/>
    <dbReference type="OMA" id="CTECFQK"/>
    <dbReference type="OrthoDB" id="10054715at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001580">
        <property type="term" value="P:detection of chemical stimulus involved in sensory perception of bitter taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031601">
        <property type="entry name" value="CCD48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF68">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15799">
        <property type="entry name" value="CCD48"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="246"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="565"/>
            <end position="569"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB72745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="621" mass="69894" checksum="4D110D7846E6C6EF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIJ8</accession>
    <name>A0A401PIJ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lactase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0006535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002217">
        <property type="protein sequence ID" value="GCB72918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PIJ8"/>
    <dbReference type="OMA" id="HIDNNDT"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB72918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1433" mass="163802" checksum="B7C7AA04D3AC98D1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIK6</accession>
    <name>A0A401PIK6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retinoblastoma-associated protein A-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0006562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002226">
        <property type="protein sequence ID" value="GCB72970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIK6"/>
    <dbReference type="STRING" id="75743.A0A401PIK6"/>
    <dbReference type="OrthoDB" id="844594at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035189">
        <property type="term" value="C:Rb-E2F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048667">
        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002720">
        <property type="entry name" value="RB_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF36">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01858">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein A-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB72970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="73" mass="8849" checksum="6A24C4E7338FCA5A" modified="2019-05-08" version="1" fragment="single">SITLTSDIQTETDLFFPWILRVFDIKAYEFYKVIESFIKAEPNLTREMIKHMERCEHRIMECIAWQTILHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ53</accession>
    <name>A0A401PJ53_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cerebral cavernous malformations 2 harmonin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0002384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000597">
        <property type="protein sequence ID" value="GCB73160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJ53"/>
    <dbReference type="STRING" id="75743.A0A401PJ53"/>
    <dbReference type="OMA" id="ETFEAYC"/>
    <dbReference type="OrthoDB" id="5828470at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13516">
        <property type="entry name" value="HHD_CCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13166">
        <property type="entry name" value="PTB_CCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.20:FF:000004">
        <property type="entry name" value="Cerebral cavernous malformation 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032375">
        <property type="entry name" value="CCM2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026159">
        <property type="entry name" value="Malcavernin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21642:SF2">
        <property type="entry name" value="CEREBRAL CAVERNOUS MALFORMATIONS 2 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21642">
        <property type="entry name" value="CEREBRAL CAVERNOUS MALFORMATIONS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16545">
        <property type="entry name" value="CCM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cerebral cavernous malformations 2 harmonin-homology" evidence="2">
        <location>
            <begin position="289"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB73160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="440" mass="49460" checksum="8995270398C3AEBF" modified="2019-05-08" version="1">MGFVSPIKRLVFPKNRRQQDRSSVYRRPLHSIPLFPPDYLIDPEILLHDYLEKEVKFLGHLTWVSCSLNPASRTEVLQLLDTARQQKQLPLQTTAEQDTILSLSARCLLLTWRDNEELILRIPTHEIAAVSYVRDDALHLLILKTGLGVAAVAAGGSLERRQATGTLSDPQEAVPNSETYCNLVILAVDSRDSAEEYCALICQVFRIIYGDQTIDCVDRAGLHYTSTPDRRWLMERSDSRQTAQTYGYDADFSCCSSFNGSQDIFDPYCSGSSSPSYRDSQFSQGTADSESDQSSTGADLLQDYMSTLRTKLTAQEIQQFALLLREYRTGASVEDYCAELLHLYGEKRKFLLLGMRAFIPDKDTGYFESFLETIGIKDGRGILTDSFGRIKRSMSNTSASAVRGYDSWSVPSESDTFERMISNITHDIEALGCDVEDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLC4</accession>
    <name>A0A401PLC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Exocyst complex component 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0002980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the exocyst complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1. Interacts with GNEFR/DELGEF; this interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP. Interacts with RALA and RALB. Interacts with ARL13B; regulates ARL13B localization to the cilium membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000778">
        <property type="protein sequence ID" value="GCB73898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLC4"/>
    <dbReference type="STRING" id="75743.A0A401PLC4"/>
    <dbReference type="OMA" id="WAARHAN"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000196">
        <property type="entry name" value="Exocyst complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPT/TIG" evidence="9">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="10">
        <location>
            <begin position="133"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB73898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="918" mass="103434" checksum="C13BCAC204CDB99F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLL3</accession>
    <name>A0A401PLL3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0003065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000808">
        <property type="protein sequence ID" value="GCB73981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLL3"/>
    <dbReference type="STRING" id="75743.A0A401PLL3"/>
    <dbReference type="OMA" id="PVSIEWY"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000528">
        <property type="entry name" value="Neural cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009138">
        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF36">
        <property type="entry name" value="NEURAL CELL ADHESION MOLECULE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB73981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="180" mass="20199" checksum="5B747515C5F966F2" modified="2019-05-08" version="1">MYVVLQVTISLGKVELSVGESKFFTCTAIGEPVSIEWYSPDGEKVISNERVVVQAEGIRSRLTIYNANEEDAGIYQCQVTDVNGKSQEATILVEIYKKLTFHEIRSPQEFREGEDAIVICEVDSSPAPMFLMTENNSLKIRRISKKNEGVYRCEGRVEARGEIDFRDIAVIVNGKITSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PM23</accession>
    <name>A0A401PM23_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-related protein Rab-7b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0003245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000872">
        <property type="protein sequence ID" value="GCB74158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PM23"/>
    <dbReference type="STRING" id="75743.A0A401PM23"/>
    <dbReference type="OMA" id="STECAEN"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000751">
        <property type="entry name" value="Rab family GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF6">
        <property type="entry name" value="SI:DKEY-13A21.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB74158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="189" mass="21187" checksum="93612E90EDD33C9D" modified="2019-05-08" version="1" fragment="single">RAGKSALMNLYVFKRYTNSYKATIGADFLIRDVTLDGKKVTMQVWDTAGTERFQSLGSVLYRGTDCCILVFDVTSEASFRALDGWRKEFLLQADPRDPDSFPFVVIGNKVDLSSSREVSTECAENWCEAHKLSYIETSVKEALNVEEAFRDCVRLSLKRLKSKDQPVAQSDHIQISPGDAKPQEPCACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PM82</accession>
    <name>A0A401PM82_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0003328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000894">
        <property type="protein sequence ID" value="GCB74240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PM82"/>
    <dbReference type="STRING" id="75743.A0A401PM82"/>
    <dbReference type="OrthoDB" id="196393at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22627">
        <property type="entry name" value="Kunitz_collagen_alpha1_VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF375">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB74240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="15009" checksum="42ECCDD0B43E427F" modified="2019-05-08" version="1">MLQVFLLTVSPLGRDFQLIIRTDDSDEDWGKVAERKKGAFDGKDYEDDSEEIEFEDEVDLGNATQLEKSMSNTTAPCSQPMDEGSCSQYELLWYYSPESNECRPFVYSGCGGNSNRFSSKQGCIDRCVQGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMX4</accession>
    <name>A0A401PMX4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 245</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0003580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000988">
        <property type="protein sequence ID" value="GCB74490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMX4"/>
    <dbReference type="STRING" id="75743.A0A401PMX4"/>
    <dbReference type="OMA" id="MYMFLTP"/>
    <dbReference type="OrthoDB" id="5970161at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB74490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="78681" checksum="FA3903AC7300B465" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNP8</accession>
    <name>A0A401PNP8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Potassium channel voltage dependent Kv4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0003844</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001078">
        <property type="protein sequence ID" value="GCB74753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PNP8"/>
    <dbReference type="STRING" id="75743.A0A401PNP8"/>
    <dbReference type="OMA" id="NTRFEET"/>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000111">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004055">
        <property type="entry name" value="K_chnl_volt-dep_Kv4.2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024587">
        <property type="entry name" value="K_chnl_volt-dep_Kv4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF265">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11879">
        <property type="entry name" value="DUF3399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01517">
        <property type="entry name" value="KV42CHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent Kv4 C-terminal" evidence="14">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB74753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28985" checksum="9F3C0DFA83CC7973" modified="2019-05-08" version="1">MGNRYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKKARLARIRVAKTGSANAFMQSKHNGLLSDSLEQMSNDEEQALVSKSGPSFQRQHHHLLHCLEKTTNHNFVDEQTYKENCLEGSTRNRSNSHSSSLLSQHGLTGTCCSRRSKKPFQLPNSNISCSHPGSVQELSTIQIRCVQQSALSNSRSSLNANVEESIKLNCEQSYITKAVICMPSPPATTPEGNNRPDSPDQAEINIVKVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PR68</accession>
    <name>A0A401PR68_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0020376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016390">
        <property type="protein sequence ID" value="GCB75610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PR68"/>
    <dbReference type="STRING" id="75743.A0A401PR68"/>
    <dbReference type="OMA" id="SHGHMEI"/>
    <dbReference type="OrthoDB" id="76949at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21802">
        <property type="entry name" value="CEN_ANKS4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09517">
        <property type="entry name" value="SAM_USH1G_HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000034">
        <property type="entry name" value="ankyrin repeat and SAM domain-containing protein 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="347"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB75610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="416" mass="46204" checksum="A3D5463DA055841D" modified="2019-05-08" version="1">MCKLHMDSDPEPGSNLGPRRPEAAGLTNCATVLSELSSRGDPNICDIWGNTPLHHASINGHLHIVTFLVNFGANIWALDNDFHSAMDAAAGKDRMECVRFLDTAATKQTTLNPKQVARLKEKAIKDSEKQIKDCERRKKKHQNRMNKKYNREMEGQSNGAAPVQSGTISSISDLFKIGGSQHKGSISSIVKGSLQKRLGKKDNSKSNMEQQLGKDVIFVSQEGSSGVRGNVFSVFNERDEGNAASADLKCSEDDNMFGQESLFNRPGLGNMLFRRNFVLGLNVEEEMFSSNELEDVGSKLRSEVLKPKESCTEPETFGEFNEEQEDDLPWNEDDIGLDDDEPETTPLETFLASQNMTEFIPILAREQIDLDSLMLCTEGDLKGIHLPLGPRKKISSAVERRNFILETPNKLVDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRN6</accession>
    <name>A0A401PRN6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STIM1/2 Orai1-activating region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0019054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013825">
        <property type="protein sequence ID" value="GCB75771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRN6"/>
    <dbReference type="STRING" id="75743.A0A401PRN6"/>
    <dbReference type="OrthoDB" id="9986177at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000011">
        <property type="entry name" value="Stromal interaction molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032393">
        <property type="entry name" value="SOAR_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF9">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16533">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="STIM1/2 Orai1-activating region" evidence="4">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB75771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="390" mass="43377" checksum="46926C8AEB9D7FD5" modified="2019-05-08" version="1" fragment="single">TRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLQKAEQSLHDLQERLQKAQEEHRSVEVEKVNLEQKLRDEINAAKQEAQRLRELREGTENELSRQKYAEEELEQVRMALKKAEKELESRGRWSPPETLQKWLQLTHEVEVQYYNIKKQSAERQLNIAKEGVSSLSLHPTVRQRQVDTQHAAGSQRDLNRSDSESSISQSSDQQRLPNSSGSPSALLHNRSIPSKPTSLLKLTEEITPTLSVASDSNAPSPNGSSSSKQAESLSSMCSENTSDSPLASRKAYPNRGLEKSASLGEIHHGAEGSALSPSESSRSLSPTSTDPESTGTDAKNGIKGTKIPQLASKKSPVEEDSTSTGEETEPNPGKKKPGFKLFKKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PS67</accession>
    <name>A0A401PS67_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0020964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01017759">
        <property type="protein sequence ID" value="GCB75979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PS67"/>
    <dbReference type="STRING" id="75743.A0A401PS67"/>
    <dbReference type="OMA" id="FRILSPY"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000154">
        <property type="entry name" value="Vesicle-fusing ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000003">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48" evidence="5">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB75979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="251" mass="27998" checksum="0E1440A202AFE6F4" modified="2019-05-08" version="1">MAVFRILSPYGFDKTKQCIGTMMIEIDFLQKKSVDSNPYDTDKMAAEFIQQFTSQAFSTSQQLVFSFNDKLFGLLVKDIEAMDPSILKGEQASGKRQKIELGLSIANSQVIFEKSGSSSLTLIGKSKTKQGRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPVDLVEQMGCKHVKGILLYGPPGCGKTLMARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRVSVLCVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSS1</accession>
    <name>A0A401PSS1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0020447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016516">
        <property type="protein sequence ID" value="GCB76184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSS1"/>
    <dbReference type="STRING" id="75743.A0A401PSS1"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040395">
        <property type="entry name" value="TTC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143:SF6">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB76184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="92" mass="10699" checksum="F22DBE9283AAC07F" modified="2019-05-08" version="1">MKGHHERAYDYVRRASDLARETSHPDEYVILNNLARVLMHKGRYSEAKLVYEEALKQAESKADQPVIERIREGLEELEAKTLKVQVLGEKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PT86</accession>
    <name>A0A401PT86_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0019876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015261">
        <property type="protein sequence ID" value="GCB76359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PT86"/>
    <dbReference type="STRING" id="75743.A0A401PT86"/>
    <dbReference type="OMA" id="YYLGCER"/>
    <dbReference type="OrthoDB" id="10062435at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16213">
        <property type="entry name" value="SELENOPROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16213:SF78">
        <property type="entry name" value="SELENOPROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29156" checksum="3D48983C93C7BE40" modified="2019-05-08" version="1" fragment="single">MASDVRQRKRQKEGEVGLREGGSRAAEARKQPAKISLWVLLGVGLLALGAGGWRYYLGCERAKQQKDALKSLGSEGLFLFSSFDTNNDLCLSPEEFKPLAEKLTGIASVPDFESSEEPDPNSEMLTIEARFQPLLLETMTKSKDGFLGVSHSALSGLRNWKSAEIPSRVFSSSLFKAFLPVKNKVELGDTWWMIPTELTIFTGYLSNNRFYPPTPQGREVIVHKLLSMLHPRPFVKTRFAPQGAVACVRASSDFYYDIVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTH7</accession>
    <name>A0A401PTH7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Huntingtin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015277">
        <property type="protein sequence ID" value="GCB76434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTH7"/>
    <dbReference type="STRING" id="75743.A0A401PTH7"/>
    <dbReference type="OMA" id="THGEQGH"/>
    <dbReference type="OrthoDB" id="10065698at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048412">
        <property type="entry name" value="Htt_bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024613">
        <property type="entry name" value="Huntingtin_N_HEAT_rpt-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20925">
        <property type="entry name" value="Htt_bridge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12372">
        <property type="entry name" value="Htt_N-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="82269" checksum="CBC084188C4C73A4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTS7</accession>
    <name>A0A401PTS7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcl-2 Bcl-2 homology region 1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008821">
        <property type="protein sequence ID" value="GCB76518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTS7"/>
    <dbReference type="STRING" id="75743.A0A401PTS7"/>
    <dbReference type="OMA" id="CCVGITW"/>
    <dbReference type="OrthoDB" id="5947850at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF48">
        <property type="entry name" value="BCL-2-RELATED OVARIAN KILLER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="8">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB76518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="11840" checksum="897825E542E2B4FF" modified="2019-05-08" version="1">MLSAPVFCCVGITWGKVVALYAVAGGLAIDCVKQGQHSMVHTIVDCLGEFVRKTLVTWLRRRGGWADITKSVVNNDSSIRDHWLVSVLCTCGHFLKAIFFFLLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PU57</accession>
    <name>A0A401PU57_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0019916</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01015330">
        <property type="protein sequence ID" value="GCB76676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PU57"/>
    <dbReference type="STRING" id="75743.A0A401PU57"/>
    <dbReference type="OMA" id="CHILAKR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF11">
        <property type="entry name" value="EPHRIN TYPE-B RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="91"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB76676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="185" mass="20828" checksum="B3AD9833054DED2B" modified="2019-05-08" version="1" fragment="single">EYQTSVQEKLPLIIGSAAAGLVFIIAVVVILIVCNRRRGFERADLEYTDKLQHYTSGHVTPGMKIYIDPFTYEDPNEAVREFAKEIDISTVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTERQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVR9</accession>
    <name>A0A401PVR9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0021072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018043">
        <property type="protein sequence ID" value="GCB77163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVR9"/>
    <dbReference type="STRING" id="75743.A0A401PVR9"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000204">
        <property type="entry name" value="Heat shock protein HSP 90-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB77163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="730" mass="84304" checksum="AD6EF2ECD0D9A1FE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVX9</accession>
    <name>A0A401PVX9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018076">
        <property type="protein sequence ID" value="GCB77275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVX9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019021857" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8034" checksum="7B27A31DFDE8D0B5" modified="2019-05-08" version="1">MPETVVSMLEFAALIVWFGAAGEESGAGGPVPEEQVALSQLGSVSGIWRQCVKSSKMWMRPCAILRSVSTHCAGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVZ0</accession>
    <name>A0A401PVZ0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0020558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016781">
        <property type="protein sequence ID" value="GCB77289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVZ0"/>
    <dbReference type="STRING" id="75743.A0A401PVZ0"/>
    <dbReference type="OMA" id="EDRTIMD"/>
    <dbReference type="OrthoDB" id="424249at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048170">
        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099577">
        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000004">
        <property type="entry name" value="Fragile X mental retardation 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000017">
        <property type="entry name" value="Fragile X mental retardation syndrome-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022034">
        <property type="entry name" value="FMR1-like_C_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032172">
        <property type="entry name" value="FXR1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF3">
        <property type="entry name" value="RNA-BINDING PROTEIN FXR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12235">
        <property type="entry name" value="FXMRP1_C_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16096">
        <property type="entry name" value="FXR_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB77289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="474" mass="52246" checksum="B8A3B0F1AB7A718C" modified="2019-05-08" version="1" fragment="single">TTKQLAAAFQEEFSVREDLMGLAIGTHGANIQQARKVPGVTAIELDEVTCTFRIYGETPEAVKQARGYLEFSENSVQVPRSLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNDKRLPREEGMVPFTFVGTKENLVNAQVLLEYHLSYLTEVEQLRLERLQIDEQLRQIGMGYRPLSTRADKERGYMTDDSTASSMHSSRSYSGRGRGRRDNNSDFSNVSEAESERRDELSDWSAGQADEERDRRQGSDPNRRRPIGGRGRGAPPSGRGRGGGRGGTSSISAVLKDPDSNPYSLLENAETDQAGDTDASEPHANANRRRRSRRRRTDDDATMMDGIVESDSASINENGVDETEGRPPRRNRSRRRRNRGNRLDGSLSRDRQPVTVADYISRADSQSRQRVTQTDQSERDPGPEPEAKQQERADPSDEPSATPNGPTSSPNGSATKTAGDSQERGQSYEQAAGPTIKQQAVVNGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW29</accession>
    <name>A0A401PW29_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008964">
        <property type="protein sequence ID" value="GCB77325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW29"/>
    <dbReference type="STRING" id="75743.A0A401PW29"/>
    <dbReference type="OMA" id="MLKNSIH"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF60">
        <property type="entry name" value="CALAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB77325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="214" mass="24811" checksum="708CC75C765ED75B" modified="2019-05-08" version="1">MSRPLDLSRKQHQQLAETLCKLTKRFNKHEVQCLMKVFSTLVATFPEQRIGIGLDRTKFRNVLHTTFGMTDDMIMDRVFRAFDKDNDSYVNMKEWVEGLSIFLRGTLDEKIKFCFDVFDLNGDGFISREEMFHMLKSSLIKQPTEEDPDEGVKDLVEIALKKMDYDHDNKVSYADFEKAVKVDNLLLEAFGPCLPDSKSALAFEEQAFKKSKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PX83</accession>
    <name>A0A401PX83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0021126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018183">
        <property type="protein sequence ID" value="GCB77720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PX83"/>
    <dbReference type="STRING" id="75743.A0A401PX83"/>
    <dbReference type="OrthoDB" id="5989317at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042590">
        <property type="term" value="P:antigen processing and presentation of exogenous peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB77720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="310" mass="33711" checksum="8972E6B707343C90" modified="2019-05-08" version="1" fragment="single">DWVLYIGLACNTARYLYISYLENAWYVLPMEVLQGVTHAAVWAACISYLSAAVPPALRTSTQGILQGLHLGLGRGCGAMVGGVMVNAFGAPQTFRGIGMASLVILLLFALIQWLAVPDEDEEKKMLAERIPVPSSPVPIATIDLVQHHSDSMMPHLETKLPLKKTKYQEDQEDVTKPAWAISSSPWVTIAFAFYQVIEMVKLAKTNTTIEHHVLQEENDCPVSADTLPVGHPPHLKSSPSSNKLATAEVPVTTSEPDEISISSTQTTENGFNQSNLPRNLIPLPGNGNQNIDPGLPKQTSIIQPSQKDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PY71</accession>
    <name>A0A401PY71_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small nuclear RNA activating complex polypeptide 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0015757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009100">
        <property type="protein sequence ID" value="GCB78072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PY71"/>
    <dbReference type="STRING" id="75743.A0A401PY71"/>
    <dbReference type="OMA" id="CEIWKEM"/>
    <dbReference type="OrthoDB" id="20127at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB78072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38861" checksum="BFDDEA773429010E" modified="2019-05-08" version="1" fragment="single">LPSGSTSLSSEIPPFCFEGLSVTEGIAVIMALTAGLKTDFENLLLRFQQTESVRYEEFSVIWRDMKFSTIFYGKMGITDGRKFTKEALALASQYFFPPYSFQIRFGGLYLLYGLYNTQLCQPKEKIRVALKEWDEVLSCQEEMVNAEHFDAVYVLKKLLNDRAFHFTAMPTLLVYNKKKRKAPNDTVNEGFREKSNLVSELITVDVLEELMNIHEHYQTMKRMISANKTQLDKALSLIRGDFVSELKNVTVEFQQWQMNKGFNRAQTLADIKSKSYNSTVKAPRSRRHRQIKLESSESGSDWGRMKQTPRSRNSSVKEHSRKQDFPAPKKRRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYQ6</accession>
    <name>A0A401PYQ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0015801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009139">
        <property type="protein sequence ID" value="GCB78289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYQ6"/>
    <dbReference type="STRING" id="75743.A0A401PYQ6"/>
    <dbReference type="OMA" id="DEMIDAR"/>
    <dbReference type="OrthoDB" id="17346at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045698">
        <property type="entry name" value="Rab3GAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19533">
        <property type="entry name" value="Rab3-GAP_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="11">
        <location>
            <begin position="517"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP catalytic subunit C-terminal" evidence="12">
        <location>
            <begin position="682"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="811"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB78289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="885" mass="100100" checksum="76B328CD31B54C9F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZ66</accession>
    <name>A0A401PZ66_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0015827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009162">
        <property type="protein sequence ID" value="GCB78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZ66"/>
    <dbReference type="STRING" id="75743.A0A401PZ66"/>
    <dbReference type="OMA" id="QPKRKGH"/>
    <dbReference type="OrthoDB" id="6233064at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740:SF3">
        <property type="entry name" value="PROBETACELLULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00009">
        <property type="entry name" value="EGFTGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="20028" checksum="C590CAB92CA77B4E" modified="2019-05-08" version="1">MLCRCFNLYSECLAWFNPATADVNSTLTMEAEKYLCAQGKQINCTDTLTEPPQLGHFSKCPERFQDYCIEGECRFIHSEQQPSCVCKFGYVGSRCQLVDMFYLTGKQDKFIIVGLILTMLVLIVLIIIICICVHRFRRKHKARRKRGDEVEALSSNPLGGKDLRGDDEDTPMTTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZP7</accession>
    <name>A0A401PZP7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0020689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017093">
        <property type="protein sequence ID" value="GCB78560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZP7"/>
    <dbReference type="STRING" id="75743.A0A401PZP7"/>
    <dbReference type="OMA" id="QESWHIR"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB78560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="156" mass="17865" checksum="A7892F7C8490524B" modified="2019-05-08" version="1">MEPSSPGDWEPSTPGNIQPYTPGNIQPSPPGRGAGSRENPVHFQQQNYERIRNRLYRDQKLFRDRKFPAGEEALGPLNKPGIEWIRASELFTNPQFFVDSISMTDICQGNLGDCWFLAAMSSLTLDENLFAYVVPSDQTFQKMYAGIFRFRVRVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q075</accession>
    <name>A0A401Q075_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division cycle protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0019458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014495">
        <property type="protein sequence ID" value="GCB78797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q075"/>
    <dbReference type="STRING" id="75743.A0A401Q075"/>
    <dbReference type="OMA" id="ISIPMVA"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB78797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32855" checksum="120365EBF295B512" modified="2019-05-08" version="1" fragment="single">CNAARCVQTLPVRQLHLVPSCNVDAWNVVILFSVAEEPQDIYWLSQCLYLTAQYHRAAHAIRSRKLDKIYGACRYFAAQCHYAAKEYQQALDILDMQEPINKIIVEKNAKVDNKIKEASIDWGLSPAAIKSSICLLRGKIYDAMDNRPLATNSYREALKLDVCCFEAFDLLTSHHMLTAQEEKELLESLPFNKQCTEEECDLLYFLYKNKLKKYNKPSETVIPESIDGLQDNLDVVVSVAERNYYNCDFKTCYKLTSMVMNKDPYHAVLLPVHIGTLVELNKANGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0A4</accession>
    <name>A0A401Q0A4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0016875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010517">
        <property type="protein sequence ID" value="GCB78811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0A4"/>
    <dbReference type="STRING" id="75743.A0A401Q0A4"/>
    <dbReference type="OMA" id="PDCEASH"/>
    <dbReference type="OrthoDB" id="48314at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF3">
        <property type="entry name" value="ALSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25582">
        <property type="entry name" value="DH_Alsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="535"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="587"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="804" mass="87183" checksum="7C7FD9BF1E4E1F05" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0C1</accession>
    <name>A0A401Q0C1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0020147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015837">
        <property type="protein sequence ID" value="GCB78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0C1"/>
    <dbReference type="STRING" id="75743.A0A401Q0C1"/>
    <dbReference type="OMA" id="LLMCSRS"/>
    <dbReference type="OrthoDB" id="9229163at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000058">
        <property type="entry name" value="immunoglobulin superfamily containing leucine-rich repeat protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019145448" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="253"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="297" mass="33755" checksum="7A62ABACFC10CA10" modified="2019-05-08" version="1" fragment="single">MYLIAVLCSLATIFTKVSSFCPSQCTCIFHSRSDGTGTRSVLCNDPDMSEVPVNVPLDTVKLRVEKTVVRQLPREAFYYLVDLRYLWLTYNAINTIDPRSFYNLKELHELRLDGNMLSTFPWNSLLEMPNLRTLDLHNNNLSNIPANAARYLRNITNLDVSSNILITLPPDLLDIWPANPRYQEFDRDPMQRVILGFQDNPWFCDCRISKLIELTKSEETPVILMDPLLTCSAPDNIAGVLFQRVELEQCLRPTVMTSATKITSPVGSNVLLRCDSTGFPTPLLVWFREGGLPVNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q155</accession>
    <name>A0A401Q155_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018527">
        <property type="protein sequence ID" value="GCB79084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q155"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB79084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="10935" checksum="9407240E8B96AE11" modified="2019-05-08" version="1" fragment="single">ISVQVPSGIAKQQGAAGSCEQWLPHSQELVSIHCNENSILPSTEWNICAESVSELQMADGLPWWYQLQGDNPTNLQTDLQNGYSSGMEMLCWVQREQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q1B7</accession>
    <name>A0A401Q1B7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative adherens-junction anchoring domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013282">
        <property type="protein sequence ID" value="GCB79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q1B7"/>
    <dbReference type="STRING" id="75743.A0A401Q1B7"/>
    <dbReference type="OrthoDB" id="1746725at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF6">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative adherens-junction anchoring" evidence="2">
        <location>
            <begin position="51"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="180" mass="20426" checksum="D2FADA789CB1F470" modified="2019-05-08" version="1" fragment="single">AGEKHYHPDCARCVRCEEMFAEGEEMYLQGILIWHPVCKQAARAEEKHKITHTSSESITSAPASSTSGSPSRIIYAKLDDEILDYKDLAALPKVKAIYNIDRPDMISYTPYINYSTINRHSLGESHRLLYPTSTEDEQEGTRQRRASSPGSFGSLGYGRYTPTWAHSPQHFHRPGNDYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q249</accession>
    <name>A0A401Q249_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013348">
        <property type="protein sequence ID" value="GCB79430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q249"/>
    <dbReference type="STRING" id="75743.A0A401Q249"/>
    <dbReference type="OMA" id="SQMHANL"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB79430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="104" mass="11789" checksum="B2176605ADB584A1" modified="2019-05-08" version="1" fragment="single">QALKVRQADVTRETVQKSVCVLSRLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNGSLGGNALEGSQASLGLSPRDLVLHFRHKTIILFKLILLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q545</accession>
    <name>A0A401Q545_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010973">
        <property type="protein sequence ID" value="GCB80485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q545"/>
    <dbReference type="OrthoDB" id="8965088at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="23592" checksum="DA1BE09B29454C10" modified="2019-05-08" version="1">MATAAPLSDGVDTAVFEMEWTLLSFEMEWMLLSLFEMEWTLLSLFEMEWTLLSLFEMEWTLLPLFKIEWILLPLFEMEWTLLPLFEMEWTMLSLFEMEWTLLSLFEMEWTLLSLFGMEWALLSFEMEWTLLSLFEMEWTLLSLFGMEWALLSRFEMEWTLLSLFEVEWTLLSLFQMEWTLLTLFEMEWTLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q643</accession>
    <name>A0A401Q643_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023705">
        <property type="protein sequence ID" value="GCB80838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q643"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="106" mass="11384" checksum="E0C871289EA81A7A" modified="2019-05-08" version="1">MLELRADQSTQLQQVAAVGDKDFYCFQCWASTFRKRDSDNHGGAEDRPGSVAGEAALRVRERANSLGPDGLAHALSALGLQQLETASSVAAEPHHVLSAQHGYHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6M0</accession>
    <name>A0A401Q6M0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Uncoupling protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0021314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018662">
        <property type="protein sequence ID" value="GCB81026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6M0"/>
    <dbReference type="OMA" id="MAARQNY"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="113"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB81026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22731" checksum="EE7798F976B1BF4B" modified="2019-05-08" version="1" fragment="single">MVGFKPTDVPPTATVKFLGAGTAACIADLFTFPLDTAKVRLQIQGEVKSAAEVATVRYRGVFGTMATMVKTEGARSLYSGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHVGVGSRLLAGCTTGAMAVAFAQPTDVVKVRFQAQANMSSQNRRYNGTIEAYKTIAKEEGIRGLWKGTMPNIARNAIVNCTELVTYDLIKDLLMKNGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7Q4</accession>
    <name>A0A401Q7Q4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0021831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020167">
        <property type="protein sequence ID" value="GCB81396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7Q4"/>
    <dbReference type="STRING" id="75743.A0A401Q7Q4"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="85" mass="10045" checksum="47CF5C0080534AF2" modified="2019-05-08" version="1" fragment="single">YYFTINFGHDAQKALDLRTEDVKDCDDWVAAIGHASYRNLATEHESLMQKYLHLLQIVETEKTVAKRLRHQIEDQEIEVERLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q7S6</accession>
    <name>A0A401Q7S6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0023286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01028012">
        <property type="protein sequence ID" value="GCB81423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q7S6"/>
    <dbReference type="STRING" id="75743.A0A401Q7S6"/>
    <dbReference type="OMA" id="KWHENDV"/>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB81423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="108" mass="12540" checksum="C45C060293C75D21" modified="2019-05-08" version="1" fragment="single">TVTVKDDAILNQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKMLPVYTSHVVNAYRGKKRAEAPPHIFSISDNAYQYMLTDRENQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q814</accession>
    <name>A0A401Q814_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0023002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025469">
        <property type="protein sequence ID" value="GCB81524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q814"/>
    <dbReference type="STRING" id="75743.A0A401Q814"/>
    <dbReference type="OMA" id="FLICDCN"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRCT" evidence="5">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="9547" checksum="82735F8F5252DFF2" modified="2019-05-08" version="1" fragment="single">DYLHRNLSGNIFSTLSPELFVALVSLKAVDFNSEFLICDCNMRWVLNWKKNTSVRITEETVCAYPKTLKGQLFKDLTESQLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8B7</accession>
    <name>A0A401Q8B7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022895">
        <property type="protein sequence ID" value="GCB81567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8B7"/>
    <dbReference type="STRING" id="75743.A0A401Q8B7"/>
    <dbReference type="OMA" id="RECACED"/>
    <dbReference type="OrthoDB" id="10031141at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035631">
        <property type="term" value="C:CD40 receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002768">
        <property type="term" value="P:immune response-regulating cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008063">
        <property type="entry name" value="Fas_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052135">
        <property type="entry name" value="TNFRSF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46875">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46875:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01680">
        <property type="entry name" value="TNFACTORR6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNFR-Cys" evidence="2">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="154" mass="17378" checksum="FDD78A7F84CE05A3" modified="2019-05-08" version="1" fragment="single">SNPLSPLGSSCDSERQYYDEELRECCGKCPPGSFAMRRCSKLSATQCESCPPGEFTAYWNYIRKCNLCPSCDHRRGLEVSRNCTSQRKTECQCREGYHCLQGLECTECEMHTECPAGYQVAQPGSHRVNTMCSKCPPGTFQNEKSLSKCRKQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q941</accession>
    <name>A0A401Q941_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025709">
        <property type="protein sequence ID" value="GCB81898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q941"/>
    <dbReference type="STRING" id="75743.A0A401Q941"/>
    <dbReference type="OMA" id="GMETIFG"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="191" mass="21937" checksum="439439EDCB9C35FD" modified="2019-05-08" version="1" fragment="single">MESIGSMRDDMRRHFRVKLKNIFTKFIRKFGFEMIDSMVPEEYHRVLVNIRKAEARSRRQRALKRGASGSESEDETPKQNGDSIEEILAETDSEDEGNEKGEKAAKKRLMKQSRAWLKEGEEDDPLNFLDQNVAQRVLATKPDLRPKTSIKHQFPVTSDGRLVIGQKAKDEEMNGSEDETNKILEEVGVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9S2</accession>
    <name>A0A401Q9S2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Interferon regulatory factor-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025828">
        <property type="protein sequence ID" value="GCB82067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9S2"/>
    <dbReference type="OMA" id="HGCKISS"/>
    <dbReference type="OrthoDB" id="5958224at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019471">
        <property type="entry name" value="Interferon_reg_factor-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF26">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01243">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor-3" evidence="2">
        <location>
            <begin position="59"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="273" mass="30101" checksum="41700152F22879C8" modified="2019-05-08" version="1">MESDSSCDPSSGSEMSAQEEGPGEITSLDWSLTPSTEVPHNYTINITSSMPPSQPEKGPNSMFISFCYGGVLVSSQVTRHGCKISSSAPPSRTDASFGSQAMEKLRFPPTGTIATPEKRKATEELLTFLERGVMLDSNTNGIFIQRLCQGRVFWTGPCASRPDQPNKLERDKVEKLFDRKKFDEDLELCQAMGVTPPQYQVTLCFGEELTETDSLTEKLITVQIHQVAAKQLVDRELELQATTFILSQLAPENFSDRVTQALREASSSLYGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCG6</accession>
    <name>A0A401QCG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0023903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01035507">
        <property type="protein sequence ID" value="GCB83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCG6"/>
    <dbReference type="STRING" id="75743.A0A401QCG6"/>
    <dbReference type="OMA" id="AICIKLY"/>
    <dbReference type="OrthoDB" id="74705at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="53" mass="6243" checksum="6587B5B5922DC4D6" modified="2019-05-08" version="1" fragment="single">IAELVATEFFEQGDKEREELKIEPIDLMNREKRDQIPSMQVGFIDAICIKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD53</accession>
    <name>A0A401QD53_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01032063">
        <property type="protein sequence ID" value="GCB83310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD53"/>
    <dbReference type="STRING" id="75743.A0A401QD53"/>
    <dbReference type="OMA" id="NTQRDTD"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="157" mass="18761" checksum="245B1D76148E8C83" modified="2019-05-08" version="1" fragment="single">MDSNTMTKTDRNPERDADRNPERDADRNTQRDTDRNTQRDTDRNTERETLTETQRETLTETHRETLTETHRETLTETHRETLTETHRETLTETQRETLTETQRETLTETQRETLTETQRETLTETQRETLTETQRETLTETQRETLTETQGETLTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDV4</accession>
    <name>A0A401QDV4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0024287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01042665">
        <property type="protein sequence ID" value="GCB83551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDV4"/>
    <dbReference type="STRING" id="75743.A0A401QDV4"/>
    <dbReference type="OrthoDB" id="10072266at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF16">
        <property type="entry name" value="CAVP-TARGET PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="155" mass="17182" checksum="7D807A37DF2EE302" modified="2019-05-08" version="1">MIAGYPPPAVRWFKDGKLIEENDHYMINEDQDGCHQLILTSVILSDMGVYRCVAENYIGVASTKAELRVDISSSDYDTAEATETSSYVSAEASLTREQNLEGVESQAEEEQLPQILEELHDVFVTAGAPILKLQIKVKGMASCHFSSESSEMFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE12</accession>
    <name>A0A401QE12_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0024081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01038883">
        <property type="protein sequence ID" value="GCB83582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE12"/>
    <dbReference type="STRING" id="75743.A0A401QE12"/>
    <dbReference type="OMA" id="HPEGHES"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020457">
        <property type="entry name" value="Znf_B-box_chordata"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01406">
        <property type="entry name" value="BBOXZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="13">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB83582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="118" mass="13899" checksum="0E30811967CF832C" modified="2019-05-08" version="1">MAEKAKKLKLNGKEKESKLHCEEHQEELKLFCETDKKLICVSCVDSQEHREHRFIPIKEAVEIYKDEVKSSLDSLTEKKSMVLEMEQQQKQKVSKIKVNVLIFDILLCYYVLQVEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE60</accession>
    <name>A0A401QE60_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0024443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01046763">
        <property type="protein sequence ID" value="GCB83632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE60"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB83632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6554" checksum="D4E711661AFFF45E" modified="2019-05-08" version="1" fragment="single">CSECISFGCHWCVVEHQCTHNPSCHGNAGQFCPEIDKAKLNTSSVMDLNIYLKNAKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF00</accession>
    <name>A0A401QF00_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0024669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01052815">
        <property type="protein sequence ID" value="GCB83998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF00"/>
    <dbReference type="STRING" id="75743.A0A401QF00"/>
    <dbReference type="OMA" id="RFVFCMD"/>
    <dbReference type="OrthoDB" id="10013941at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000022">
        <property type="entry name" value="Histo-blood group ABO system transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005076">
        <property type="entry name" value="Glyco_trans_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10462">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10462:SF53">
        <property type="entry name" value="HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03414">
        <property type="entry name" value="Glyco_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB83998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="27072" checksum="C56B87705335E1DC" modified="2019-05-08" version="1" fragment="single">PILSTSYIDRFLKDFLETAEQHFMRGQRVIYYVLVDNVSKVPALKLSPERTMTVLHVPKFSRWQDISMMRMEQISTLIQERIRHEVTYLFCLDVDLLFVGHFGPEALGDLVAQLQAGVYPNAPKSFTFEQRPQSAAYIAPGQGDYYYHAALFGGRPELVYNLTRACMAGVSKDKVTGIEAVWHEESHLNRYFLDHKPTKLLSHEFCWDRTPRSYIKLPRIKWIPEEYKIVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF58</accession>
    <name>A0A401QF58_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0024671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01052858">
        <property type="protein sequence ID" value="GCB84006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF58"/>
    <dbReference type="STRING" id="75743.A0A401QF58"/>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000004">
        <property type="entry name" value="EF-hand domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="72"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB84006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="215" mass="23985" checksum="C6A37C8324D52616" modified="2019-05-08" version="1" fragment="single">KSNFHRSQTFSYKNGIALPVVPKVGIGGEPLHVNQLSVSDVDELANKRPTLTYGQAKQTPPADFIPGHVAFDKKVLKFDGYFKETVHESPQEYYRVRPIVLYYYLEDDSIAIHEPEVDNAGLPQGKLINRQRLPKNDQGDCWHWKDLNVAMDLVAYGKRYRLTCCDKFTCVGSSSANVTSPALSLVKGCLCNIFIGISKAHVCCRQGEISQCSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFX6</accession>
    <name>A0A401QFX6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01066622">
        <property type="protein sequence ID" value="GCB84274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFX6"/>
    <dbReference type="STRING" id="75743.A0A401QFX6"/>
    <dbReference type="OMA" id="YHTWHES"/>
    <dbReference type="OrthoDB" id="6095487at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="228" mass="25231" checksum="1F326446F751851C" modified="2019-05-08" version="1">MDELAHDLASALDETSEQNLLEQEIWDGPVLCPRQQQRRQARKRRGRKRRSNSNHSLDYARCYSEASESSQDEVGGGGGIAGGGGGSDSDDDGAVVKRLSSLNVTLKGKYHTWHESDSFTENTPGQPLRRRRKVKRVTSGGAGDVSATLQKKLKVSEPEPGSQPPPCPLKSPCQHKKQRLCKTPPEESWLSPEVLSVQPCLRLEQAHKEGMLCETEEQKASDENMTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGI8</accession>
    <name>A0A401QGI8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01075455">
        <property type="protein sequence ID" value="GCB84476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGI8"/>
    <dbReference type="OMA" id="THEHSRI"/>
    <dbReference type="OrthoDB" id="9950662at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="138" mass="15011" checksum="AE3F105D112E3925" modified="2019-05-08" version="1" fragment="single">RGALTGASKLNSTTLVTNRPVTCHPTGAHLTASVIPSRSRPGITPTAPTKPAPAPEPPYTRNITASSKLVAKLPAPPVRAESQTHEHSRIVRKEYEPSKVVITTRYIDVDPETALSSEQLQEKQRTVEKIKTMIAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGK5</accession>
    <name>A0A401QGK5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0025199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01075596">
        <property type="protein sequence ID" value="GCB84500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGK5"/>
    <dbReference type="STRING" id="75743.A0A401QGK5"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20766:SF2">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20766">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB84500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="49" mass="5173" checksum="5B5A34AA6F84A083" modified="2019-05-08" version="1" fragment="single">TCFAISCLLIAYGASNPVELSVLIFIALALNGFGGMCMTFTSLTVRNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGN4</accession>
    <name>A0A401QGN4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01069365">
        <property type="protein sequence ID" value="GCB84544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGN4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="220" mass="23359" checksum="36AE346CB9C65EB6" modified="2019-05-08" version="1">MDPDPTLGSLCVRPGPGLGYLWILIRVWDDSVDPDPDRSVDPDPNPGSLCVSRSGISLWIPIRVWITLWILIWAWDHSVDLDPGLGSLCGSQSGSGISADPDTGLGSLWILIRVWDHSVDLDPGLGSLCGSQSGYVISVDPDPGLGSLCGSRSGSGITVDPHLAPGSLCGSRSGSGITLWIPIRLWDHSVDPVPGLGSLWNPLWVWDHSLDPDPESLCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH17</accession>
    <name>A0A401QH17_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01087169">
        <property type="protein sequence ID" value="GCB84679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH17"/>
    <dbReference type="STRING" id="75743.A0A401QH17"/>
    <dbReference type="OMA" id="TNCIKGF"/>
    <dbReference type="OrthoDB" id="8904524at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="359" mass="44198" checksum="F66E4932EC31BFEB" modified="2019-05-08" version="1" fragment="single">MLKSGSKEVVNKKIIINVRKEFIINVRKEFIIINVRKEFIIINVRKEFIINVRKEFIINTRKEFIINVRKEFIINVRKEFIINARKEFIINVRKEFIINVRKEFIINAKKEFIIINVRNEFIINVRKEFIINVRKEFIIINVRNEFIINVRKEFIIINVRKEFIINARKEFIINVRKEFIINVRKEFIIINARKEFIIINVRKEFIINVRNEFIINVRKEFIINVRKEFIIINVRNEFIINVRKEFIIINVRKKFIINVRKEFIINARKEKEFIIINVRKEFIINVRKEFIIINVRNEFIIIHVRNEFIINVSNEFIINVRKEFIINVRKEFIIINVRKEFIINVRKEFIINVRNEFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIX9</accession>
    <name>A0A401QIX9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0025942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01142261">
        <property type="protein sequence ID" value="GCB85335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIX9"/>
    <dbReference type="OrthoDB" id="8950002at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB85335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="219" mass="24774" checksum="B158361A605F9FF0" modified="2019-05-08" version="1">MMIHGLRNEHYVVLSYTDLSVWCYGCESYVHNEYSEWDTETGTACSVFRAGYEDRDCVLSIPSGIRTPGTRAWYSERGRETMTVCRVFRVGYGDWDRVLGISSGIRRPGPRARYFERDTETGTASLVFRAGYGDWDRVADIPSGIRRLGPRARYSERDTETGTACLVFRAGYGDWDHVPGIPSGIRRLEYSECDSETGTGARYSEWDTETGSACSVFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ26</accession>
    <name>A0A401QJ26_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01152789">
        <property type="protein sequence ID" value="GCB85381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ26"/>
    <dbReference type="OMA" id="PIGFLCK"/>
    <dbReference type="OrthoDB" id="9042900at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031366">
        <property type="entry name" value="DUF4663"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36872">
        <property type="entry name" value="GENE 5901-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36872:SF1">
        <property type="entry name" value="GENE 5901-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15668">
        <property type="entry name" value="DUF4663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="235" mass="26702" checksum="3D447F5026F074CC" modified="2019-05-08" version="1" fragment="single">ICNTYLGLHVVPVPYLVDAERYDLLNVLLERSESLGSQLLRRKSFFPLGSLKEIVANISQENFEVMEQNIQSTSLSPNEFNHEEVVIDEGVLKSIKLVVKDVNKAVSLFIVNPGTLKLMHNLPWIYSVRNVYIIYEVFYTTNIQLLVSDSKQTQEFRSKSRIPIGFLCKKFKLSSGGIIGSEVPLKKSLVKENFVNTSSYIYEAVVGKHFVTSVHQLPQRNYKSTSLFRSILPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJP0</accession>
    <name>A0A401QJP0_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01172218">
        <property type="protein sequence ID" value="GCB85607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJP0"/>
    <dbReference type="STRING" id="75743.A0A401QJP0"/>
    <dbReference type="OMA" id="QMPGHAW"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="149" mass="18381" checksum="19EA50872FBCEA33" modified="2019-05-08" version="1" fragment="single">MVPEGQGMVQRDKAWSLKDKAWFMRDKAWSLRDMAWSMRDIAWSMRDKAWSMRDKAWSLRDMAWSMRDMTWSMRDKAWSLRDMAWSMRDIAWSMRDKAWSMRDKAWPLRDMAWSMRDIAWSMRDKAWSMRDKAWSLRDMAWSMRDKAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJQ5</accession>
    <name>A0A401QJQ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0026284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01178621">
        <property type="protein sequence ID" value="GCB85625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJQ5"/>
    <dbReference type="STRING" id="75743.A0A401QJQ5"/>
    <dbReference type="OMA" id="HCAIRAT"/>
    <dbReference type="OrthoDB" id="9945523at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367:SF45">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB85625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="96" mass="11160" checksum="5AED8138A7FAD4D5" modified="2019-05-08" version="1" fragment="single">LSDGDSVTQRESSLTQTEREDVTLSCTYTDDALYLFWYRQYPDREPEFAVRRHTGGGAELKADFAQDRFSDTVQQSDKLYRLTISELRLLLCRVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJY1</accession>
    <name>A0A401QJY1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01182995">
        <property type="protein sequence ID" value="GCB85660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJY1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="95" mass="11099" checksum="57170E742D0B0EE7" modified="2019-05-08" version="1" fragment="single">RERERESKNEKESESESESEKESKNEKESKGKKESESEKEKRERESKNEKESESEKESESEKDSASEKESKGKKESESVKESEKESESEKESESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKG7</accession>
    <name>A0A401QKG7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01205628">
        <property type="protein sequence ID" value="GCB85813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKG7"/>
    <dbReference type="STRING" id="75743.A0A401QKG7"/>
    <dbReference type="OMA" id="CIRSSMS"/>
    <dbReference type="OrthoDB" id="10242127at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36910:SF8">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="346" mass="36919" checksum="C6EFD47E5614851D" modified="2019-05-08" version="1" fragment="single">MRSGAGINEDMRSGAGINEDMRSGASTNEDMRNGAGTNEDMHRGDSTNEDMRNGASINKDMSSGASINEDMRIGAGTNEDMHRGDSTNEDKRCGAGTNARMRSGASINEDMRSGDSTNEDMRSGDSTNEDMHSGDSTNEDMRSDDSINEDMHSGDSTNEDMRRGDSTKEDMRSGASTDDDMRSGASINEDMRSGAGINEDMRSGDSNNEDMRSGASTNEDMRSGDSKNEDMRSGASTNEDMQSVTSINEDMRSGASINEEMHSGASINEDMLSGTSINEDMRSGDSINEGMRSGASINEDMLSGASSNEDMRSGVSINEDMRSGTGTNEDMRSGAGINEDMRSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL60</accession>
    <name>A0A401QL60_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-galactose translocator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0026825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01245595">
        <property type="protein sequence ID" value="GCB86125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL60"/>
    <dbReference type="STRING" id="75743.A0A401QL60"/>
    <dbReference type="OMA" id="FFAYTPM"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB86125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25268" checksum="561B210EE988229B" modified="2019-05-08" version="1">MFWRPWQVMYQFKILTTALFSVLMLQKSLSRLQWASLLILFTGIAIVQVTQEEGRAGKDRAPGQNYLVGLMAVLVSCVSSGFAGVYFEKTLKGTSASVWLRNVQLGIFGTLLGLLAMWWKDGQDIGEKGFFFAYTPMVWCVVFDQALGGLLVAVVVKYADNILKGFAASLSIIISTVASVYLFGFNVDVYFVLGAGLVIGAVYLYSLPKVLPSASLAQEPESYNTKLVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMY3</accession>
    <name>A0A401QMY3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0027476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
            <orientation evidence="9">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01347862">
        <property type="protein sequence ID" value="GCB86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMY3"/>
    <dbReference type="OrthoDB" id="6264340at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981:SF1">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15065">
        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="45" mass="5068" checksum="E19593373502F208" modified="2019-05-08" version="1" fragment="single">MEGLEARGNRSRFALELVVLEGAGAQRELRVSRSIDDEYTPSIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH13</accession>
    <name>A0A401NH13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0012667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006185">
        <property type="protein sequence ID" value="GCB60041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH13"/>
    <dbReference type="STRING" id="75743.A0A401NH13"/>
    <dbReference type="OrthoDB" id="10055806at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF14">
        <property type="entry name" value="BUTYROPHILIN SUBFAMILY 2 MEMBER A2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB60041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20616" checksum="7D85385E8B692DD0" modified="2019-05-08" version="1">MKLERGRAEDAGQYKCFVSNIKGSDQDTLSLIFAAFYKEPDFFIQLRPSGAVFKFETQGYPKASVSWYNEENEDISPLSETLYQQSGDGLYSLQSILEIGDANRSSNYTFRLRNDVLHQSVSRTFGLSKEPKPYETRTRNRWLFAVPLLIAEFLIILILVRALYQRQSHPIIRETQNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NH17</accession>
    <name>A0A401NH17_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002364">
        <property type="protein sequence ID" value="GCB60116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NH17"/>
    <dbReference type="STRING" id="75743.A0A401NH17"/>
    <dbReference type="OMA" id="HMERIRF"/>
    <dbReference type="OrthoDB" id="2133912at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031870">
        <property type="term" value="F:thromboxane A2 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046548">
        <property type="term" value="P:retinal rod cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000073">
        <property type="entry name" value="protein fantom isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041091">
        <property type="entry name" value="RPGRIP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF4">
        <property type="entry name" value="PROTEIN FANTOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18111">
        <property type="entry name" value="RPGR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="765"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="930"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="305"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="479"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="945"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1056"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB60116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1254" mass="144784" checksum="F3DBD0F2E1DDD402" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NI92</accession>
    <name>A0A401NI92_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear mitotic apparatus protein 1 N-terminal hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004982">
        <property type="protein sequence ID" value="GCB60588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NI92"/>
    <dbReference type="OMA" id="EAFRQCQ"/>
    <dbReference type="OrthoDB" id="2436455at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HkD_NuMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MT-Golgi_org_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048724">
        <property type="entry name" value="NuMA_N_HOOK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902:SF24">
        <property type="entry name" value="NUCLEAR MITOTIC APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902">
        <property type="entry name" value="NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOOK_N_NuMA"/>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
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            <end position="788"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1448"/>
        </location>
    </feature>
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        <location>
            <begin position="1682"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1744"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1859"/>
            <end position="1995"/>
        </location>
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        <location>
            <begin position="226"/>
            <end position="515"/>
        </location>
    </feature>
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        <location>
            <begin position="544"/>
            <end position="645"/>
        </location>
    </feature>
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        <location>
            <begin position="1325"/>
            <end position="1359"/>
        </location>
    </feature>
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        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="950"/>
        </location>
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        <location>
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            <end position="1446"/>
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            <begin position="1753"/>
            <end position="1765"/>
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            <end position="1794"/>
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            <end position="1917"/>
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            <end position="1976"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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            <dbReference type="EMBL" id="GCB60588.1"/>
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            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1995" mass="226465" checksum="503C43F7DC6BA517" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIJ1</accession>
    <name>A0A401NIJ1_SCYTO</name>
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        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">scyTo_0014209</name>
    </gene>
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        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007546">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
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            <end position="534"/>
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            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="523"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="720"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1335" mass="148095" checksum="D9771DDE33A915F3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIR3</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="6">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0012797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006300">
        <property type="protein sequence ID" value="GCB60772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="75743.A0A401NIR3"/>
    <dbReference type="OMA" id="DNEYQRI"/>
    <dbReference type="OrthoDB" id="8888059at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051249">
        <property type="entry name" value="NLRP_Inflammasome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985:SF2">
        <property type="entry name" value="APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="6">
        <location>
            <begin position="488"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="581" mass="67422" checksum="D08335E45DA5384C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIS4</accession>
    <name>A0A401NIS4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0009228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003711">
        <property type="protein sequence ID" value="GCB60757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NIS4"/>
    <dbReference type="OMA" id="DLYIREH"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001313">
        <property type="entry name" value="Helicase with zinc finger domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001373">
        <property type="entry name" value="Helicase with zinc finger domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056787">
        <property type="entry name" value="OB_HELZ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25049">
        <property type="entry name" value="OB_HELZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB60757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2821" mass="322613" checksum="115DF68099610AA3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJE8</accession>
    <name>A0A401NJE8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0009261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003735">
        <property type="protein sequence ID" value="GCB60979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJE8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB60979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="13295" checksum="3E1CAEAECA41DAC3" modified="2019-05-08" version="1">MPLRAKLQKKVNRQIACYPNASHIRLMHIKLLCGFIADFLLKYRWVEKVKMFLRCDKKAHEGKDESDFAANDDEERVFNADNEANLAKISLLKIPALSPCSVNATKNKVPHCPSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJI9</accession>
    <name>A0A401NJI9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">scyTo_0009270</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ag(+)(out) = Ag(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75207"/>
            <dbReference type="ChEBI" id="CHEBI:49468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Cu(+)(out) = Cu(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75211"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Apical cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Early endosome membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 22">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003739">
        <property type="protein sequence ID" value="GCB61032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJI9"/>
    <dbReference type="STRING" id="75743.A0A401NJI9"/>
    <dbReference type="OMA" id="HEGHMMK"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF22">
        <property type="entry name" value="HIGH AFFINITY COPPER UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 22" id="KW-0186">Copper</keyword>
    <keyword evidence="12 22" id="KW-0187">Copper transport</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="15 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0558">Oxidation</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GCB61032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="251" mass="27214" checksum="89FAB1B65BB3671C" modified="2019-05-08" version="1">MRRADDVSAPFDVAASAPSRRPRAVGGACCWCRAGGRGRCGVSGSAGLRGAEKGTLLEGLVFSTPTMNMSMGDGNHHMTMSPDDHTHHSRTSEMVHDHNSGGMMQMSFYFGYKNVELLFPGLVINSVGGMVGACVVVFLCALAYEGLKISRECLLRKSQVNVRYNSMPVPGPNGTILMETHKTVGQQMFSIPHLIQTVLHVVQVVTSYFLMLVFMTYNGYLCIAVALGAGAGYFLFSWKKAVVVDITEHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJX4</accession>
    <name>A0A401NJX4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Muscarinic acetylcholine receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0011263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005058">
        <property type="protein sequence ID" value="GCB61160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJX4"/>
    <dbReference type="STRING" id="75743.A0A401NJX4"/>
    <dbReference type="OMA" id="PAMENDT"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008016">
        <property type="term" value="P:regulation of heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006940">
        <property type="term" value="P:regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000038">
        <property type="entry name" value="Muscarinic acetylcholine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001065">
        <property type="entry name" value="Musac_Ach_M2_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF207">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00539">
        <property type="entry name" value="MUSCRINICM2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="48"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="476" mass="53121" checksum="7E0CA727697D7931" modified="2019-05-08" version="1">MENSTETTESLNDLTGVFDAEIESPYNPVEMVFIVILTGSLSLVTIIGNILVIVSIKLNRHLQTINNYFLFSLACADLIIGVFSMNIFTIYTVSGYWPLGPVVCDLWLSVDYVASNASGMNLLVISFDRYFCVTKPLSYPVRRTAKVAGLIIAAVWVLSFIMWAPAIIFWQFIVGQRTVGEGECYVQLFSNPVVTFGTAVAAFYLPVIIMVILYVQISHASKSRIQDDKKETGPSKCTVPHSQVKGKIMKRNHCNIFNVPSVLANIKMQDEKPTGAVIINNCCQGNEKELSKELTFCNVEQSKQNDGGTIQGSMYVSDIQSHFRMDNSKLSIIKIVRKFQKRSDCGASERRVSGLNSRNRNDKESGKDKKIITMTNAPVKKKNKGAVSRGEKVTRTILAILLAFIITWSPYFVTVLINTFCSICIPSTVWTIGFWLAYINSTINPACYAMCNPTFKKTFKHLLLCQYKRIGGKGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKH1</accession>
    <name>A0A401NKH1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0004088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001180">
        <property type="protein sequence ID" value="GCB61411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NKH1"/>
    <dbReference type="OMA" id="CYMPVVD"/>
    <dbReference type="OrthoDB" id="79771at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057537">
        <property type="entry name" value="C2_C2CD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254:SF1">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25339">
        <property type="entry name" value="C2_C2CD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="791"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1624"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2035"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2261"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2035"/>
            <end position="2049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="2375" mass="264299" checksum="A594FD98D7CB90CE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLN9</accession>
    <name>A0A401NLN9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007697">
        <property type="protein sequence ID" value="GCB61759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLN9"/>
    <dbReference type="STRING" id="75743.A0A401NLN9"/>
    <dbReference type="OMA" id="CINCDIL"/>
    <dbReference type="OrthoDB" id="419617at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="3">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB61759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="211" mass="23897" checksum="A5261D55272F8EDB" modified="2019-05-08" version="1">MKPRKLKELESLLQQVDVFEQPKLLLEQYPTSPHIAAHMLYTIHTTFNDIESKLIGDLGCGCGVLSIGAAMLDAGLCVGFDIDEGALDIFNRNAEEFELANVNMVQCDICSVMTGKLSKTFDTIIMNPPFGTKHNKGMDMAFLRTALDMARTAVYSLHKTSTRNHILKKAEEWKVKMEVIAELKYDLPASYKFHKRKSIDIEVDFIRFSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM12</accession>
    <name>A0A401NM12_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tumor protein D52-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005159">
        <property type="protein sequence ID" value="GCB61925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM12"/>
    <dbReference type="STRING" id="75743.A0A401NM12"/>
    <dbReference type="OMA" id="PNQDINL"/>
    <dbReference type="OrthoDB" id="10000687at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF13">
        <property type="entry name" value="TUMOR PROTEIN D54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB61925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22663" checksum="9440676C42E55340" modified="2019-05-08" version="1" fragment="single">RAAGLAPSLLESSLHSWRSSTFTSVSMDAPNQDINLNSPNKGLSGNMTDVPVDTPASGDGVGVLSEAETEELKSELTKVEDEIATLRQVLVAKERHASDIKRKLGLTPFNELKQNLSKSWQDVQASNAYKKTQATLSTAGSKTTSAISSVGSVLTRTLGEIKESPTFKSFEESVGNLKAKVIGNENNSKGGYHTPTASSPSAEEKLPQDNAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMP4</accession>
    <name>A0A401NMP4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001228">
        <property type="protein sequence ID" value="GCB62119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMP4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB62119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="11379" checksum="13CBB87EF0DB8A36" modified="2019-05-08" version="1">MLKQKQKRTFSLCMCGNQAPGGDVWERTVAQEVSKPGQYGAPTWRDGLLYPLTVNQRKDLRISRIVSKFVIGIRTCISGRWANGANACQFLPGTPLQGKPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMW9</accession>
    <name>A0A401NMW9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HYDIN/VesB/CFA65-like Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0011431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005195">
        <property type="protein sequence ID" value="GCB62199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMW9"/>
    <dbReference type="STRING" id="75743.A0A401NMW9"/>
    <dbReference type="OrthoDB" id="442692at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033305">
        <property type="entry name" value="Hydin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053">
        <property type="entry name" value="DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053:SF0">
        <property type="entry name" value="HYDROCEPHALUS-INDUCING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="6">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB62199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="449" mass="49752" checksum="5004A65800B7840A" modified="2019-05-08" version="1" fragment="single">EGDIWPNSTAEINVICRPKKAKIYDQTFYCDIAGRETRLPLRIKCEGLGPKVILNVDQVEIGNVFVSSKQTYEIVMANTGEIPAVYTQIPSRTHLCSCFCFNPNEGILMPHGYQIIAVTFNATFLGDFLADLFISVQGTHEPVQVTFKGCVIGPTFHFNVPILNFGEVSFGFPKTISCCLINTSLVPMAIKLRIPGDGIGEISRTSFSQVTERRSINSWANIESDITLKEFTINPSFDIIKSHVGKEIQVSFCPNTTKKYELPLIVEVENVGLEVIAIPIVARCIVPTLEVVNSHIDLGRCFLKHPYQCTIKLQNTNDLPGCYGLVPQECTNQLGILYSSPEPYGIIDPCSTVEIPLIVQAQYIGEINTEVSIALFGKSQLPLIVHISCIGEGPVVHLSSTKIDWGKIQVLTDVPKTICLSNESLIPARVTAKMVSRLDLFKRKYVQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNS7</accession>
    <name>A0A401NNS7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">scyTo_0013079</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61996"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:19466"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:231527"/>
            <dbReference type="ChEBI" id="CHEBI:231528"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:61997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01006540">
        <property type="protein sequence ID" value="GCB62523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NNS7"/>
    <dbReference type="OMA" id="LMMHHAY"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05495">
        <property type="entry name" value="Bromo_cbp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20910">
        <property type="entry name" value="NCBD_CREBBP-p300_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15802">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02337">
        <property type="entry name" value="ZZ_CBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.20:FF:000001">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1020.10:FF:000001">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1020.10:FF:000002">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.40:FF:000001">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000003">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000001">
        <property type="entry name" value="Histone acetyltransferase p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000034">
        <property type="entry name" value="Histone acetyltransferase p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1630.10">
        <property type="entry name" value="Nuclear receptor coactivator, CREB-bp-like, interlocking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003101">
        <property type="entry name" value="KIX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009110">
        <property type="entry name" value="Nuc_rcpt_coact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014744">
        <property type="entry name" value="Nuc_rcpt_coact_CREBbp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037073">
        <property type="entry name" value="Nuc_rcpt_coact_CREBbp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056484">
        <property type="entry name" value="PHD_P300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010303">
        <property type="entry name" value="RING_CBP-p300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038547">
        <property type="entry name" value="RING_CBP-p300_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09030">
        <property type="entry name" value="Creb_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02172">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23570">
        <property type="entry name" value="PHD_P300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06001">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47040">
        <property type="entry name" value="Kix domain of CBP (creb binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69125">
        <property type="entry name" value="Nuclear receptor coactivator interlocking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50952">
        <property type="entry name" value="KIX"/>
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    <keyword evidence="18 25" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="20" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
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    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
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            <end position="408"/>
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            <end position="408"/>
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    <feature type="region of interest" description="Disordered" evidence="28">
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        <location>
            <begin position="255"/>
            <end position="268"/>
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            <begin position="305"/>
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        <location>
            <begin position="471"/>
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        <source>
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    <sequence length="2436" mass="267495" checksum="A1D4A99D0FDA9436" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP86</accession>
    <name>A0A401NP86_SCYTO</name>
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        <recommendedName>
            <fullName evidence="3">CTCK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0013104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006563">
        <property type="protein sequence ID" value="GCB62718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:bursicon neuropeptide hormone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
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    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Bursicon_suB"/>
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        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058755">
        <property type="entry name" value="Fn1-VW_OTOGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41151">
        <property type="entry name" value="PARTNER OF BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41151:SF1">
        <property type="entry name" value="PARTNER OF BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25960">
        <property type="entry name" value="Fn1-VW_OTOGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
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            <begin position="300"/>
            <end position="349"/>
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    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS01225"/>
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    </evidence>
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            <dbReference type="EMBL" id="GCB62718.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="371" mass="41068" checksum="B724D5362D9DFB66" modified="2019-05-08" version="1" fragment="single">CDPQKCESDIPTCQEDQTLIATRADGSCCFAYICMCGACADKIPNCQKGELLTIGNNTTEMCCPAYQCVCEINRCPRFQCPSGMIVVEAWSPDLCCPFHSCECACDTVPKPQCKLEELLVLEQQPGNIMTNPCGCPEYKCGIDQVCIDGERGILHPGQTIVEHKADGMCYTRQCTYNLDNKTGFYLLLNQVYIPPPDLTTCCGHCKNVSCLANLKNETTTMRKPGTSWLSNCVRHDCTDTVSGPVLITLNISCPPFNETECLKTGGSVIAYMDGCCKSCKEDVKSCQKVVVRMTIRKNDCRSNRPVNIVSCDGKCPSASIYNYSINTHARFCKCCREIGLQKRTVQLYCSSNSTWVNYSIQEPTDCSCQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQS4</accession>
    <name>A0A401NQS4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin--tyrosine ligase</fullName>
            <ecNumber evidence="11">6.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0013173</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17605"/>
            <dbReference type="Rhea" id="RHEA-COMP:16434"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149554"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.25" evidence="11"/>
    <dbReference type="EMBL" id="BFAA01006626">
        <property type="protein sequence ID" value="GCB63220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQS4"/>
    <dbReference type="STRING" id="75743.A0A401NQS4"/>
    <dbReference type="OMA" id="SAGAKXK"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004835">
        <property type="term" value="F:tubulin-tyrosine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052492">
        <property type="entry name" value="Tubulin-tyrosine_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB63220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="221" mass="25088" checksum="5A16A10F2BED13FB" modified="2019-05-08" version="1">MYTFVVRDRNSSIYAEVGKVLISTGQWRRLKRDNPRFNLMLGERNKLPFGTLGHEPGLAQLVNYYRGADKLCRKASLVKLIKTIPELMESCTWFPESYVIYPIGLQTTVIPVKNGIKAQRNNVRTDDREAFLASYHKRQGNGESNVWIAKSSAGAKGTGIFISSDANELMDYIDNQGQVHVIQKYLERPLLLEPGHRKFDISILIKQYNSAATPSYQVMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQW8</accession>
    <name>A0A401NQW8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005330">
        <property type="protein sequence ID" value="GCB63311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQW8"/>
    <dbReference type="STRING" id="75743.A0A401NQW8"/>
    <dbReference type="OMA" id="QWGIRPP"/>
    <dbReference type="OrthoDB" id="10071118at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="317" mass="31812" checksum="0B16A664BBBECC05" modified="2019-05-08" version="1">MLTAAAVLTAVPHEAAVLIAVPHEAAVLTAVPHEAAVLTAVPHEAAVLTAVPHEAAVLIAVPHEAAVLTAVPHEAAILTAMPHEAAVLIAVPHEAAVLTAASHEAAVLIAVPHEAAVLTAAPHEAAVLIAVPHEAAVLTTVPHEAEVLSAMPHEAAVLIAVPREAAVLTAASHEAAVLIAVPHEAAVLIAVPHEAAVLTAAPHEAAVLIAVPHEAAVLTAVPHEAEVLIAVPHEAAVLIAVPQEAAVLTAVRHEAAVLIFMPHKATVLTTVPHEAAVLTSVPHEAAVLTAVPHVAAVLIAVPHEAAVLTAVPHEGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRK2</accession>
    <name>A0A401NRK2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006660">
        <property type="protein sequence ID" value="GCB63477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRK2"/>
    <dbReference type="STRING" id="75743.A0A401NRK2"/>
    <dbReference type="OMA" id="SINMDTE"/>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031849">
        <property type="term" value="F:olfactory receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026096">
        <property type="entry name" value="R-trans_p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14402">
        <property type="entry name" value="RECEPTOR TRANSPORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14402:SF20">
        <property type="entry name" value="RECEPTOR-TRANSPORTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="8">
        <location>
            <begin position="115"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="231" mass="26903" checksum="989FF777D7AE9D11" modified="2019-05-08" version="1">MKRHPASTGKEGREREGGCISKSGELFFRTNTQICSIAKAIYFLTKLLLCAGGIYCQSERKMSRVPGKNPWIDLFTKRVEEMEFEARWTLNFNYSLCPVLDGEQRREGWKIYKTSAFGRFDCRCSNSWSSAHVVILFHYRLRKKRGLVLIRLLRQGCRDCWDSPELKPQVTHPQIQKVFDRLIQKICKNCYGETVEEIERVLEHRKTKPHETSFCEACKLGICRNQADAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NS23</accession>
    <name>A0A401NS23_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0000184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000031">
        <property type="protein sequence ID" value="GCB63698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NS23"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="137" mass="15638" checksum="40F0DBEED257AFB8" modified="2019-05-08" version="1">MAAQSANKDSGVRLHLGQHRAAGSRGAERPPPTLQTAFQQFRSRRQMLPNLNTSSIFCHMLFLRLSNLMTWITKDNEFLCSSSINNNHINPLFKCAAINKKRHTAQFYPQFMMPSDPSNSTILQCKHVWLVLPFYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSL5</accession>
    <name>A0A401NSL5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0009726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004049">
        <property type="protein sequence ID" value="GCB63832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSL5"/>
    <dbReference type="STRING" id="75743.A0A401NSL5"/>
    <dbReference type="OMA" id="WDYETTA"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053053">
        <property type="entry name" value="WD_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44566">
        <property type="entry name" value="TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44566:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB63832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="514" mass="57962" checksum="2BAFD7EE6AF868BD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU92</accession>
    <name>A0A401NU92_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">E3 ubiquitin-protein ligase UHRF</fullName>
            <ecNumber evidence="18">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase UHRF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ubiquitin-like PHD and RING finger domain-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ubiquitin-like-containing PHD and RING finger domains protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">scyTo_0009805</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="18">The YDG domain mediates the interaction with histone H3.</text>
    </comment>
    <comment type="domain">
        <text evidence="18">The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="18"/>
    <dbReference type="EMBL" id="BFAA01004098">
        <property type="protein sequence ID" value="GCB64410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU92"/>
    <dbReference type="STRING" id="75743.A0A401NU92"/>
    <dbReference type="OMA" id="IEVGMCW"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15617">
        <property type="entry name" value="PHD_UHRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16770">
        <property type="entry name" value="RING-HC_UHRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20458">
        <property type="entry name" value="Tudor_UHRF2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17123">
        <property type="entry name" value="Ubl_UHRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.280.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000143">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1150:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000066">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047467">
        <property type="entry name" value="PHD_UHRF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047466">
        <property type="entry name" value="RING-HC_UHRF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021991">
        <property type="entry name" value="TTD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047468">
        <property type="entry name" value="Ubl_UHRF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
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    <sequence length="863" mass="97059" checksum="7112B930895DB371" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVI0</accession>
    <name>A0A401NVI0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diacylglycerol kinase (ATP)</fullName>
            <ecNumber evidence="3">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0007601</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="entry name" value="DIACYLGLYCEROL KINASE DELTA"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="59"/>
            <end position="152"/>
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    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
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            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="323"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="544"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB64888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="544" mass="60627" checksum="B85123BFB40BEC5E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW70</accession>
    <name>A0A401NW70_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0009921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004168">
        <property type="protein sequence ID" value="GCB65107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NW70"/>
    <dbReference type="OMA" id="MCHRRTA"/>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13183">
        <property type="entry name" value="FERM_C_FRMPD1_FRMPD3_FRMPD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21943">
        <property type="entry name" value="LGNbd_FRMPD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000009">
        <property type="entry name" value="FERM and PDZ domain containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000066">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049385">
        <property type="entry name" value="FAK1-like_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041779">
        <property type="entry name" value="FRMPD1/3/4_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF4">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21477">
        <property type="entry name" value="FERM_C_FAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="80"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1715"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1730"/>
            <end position="1739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1921" mass="213167" checksum="CA430B96066E2029" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWV0</accession>
    <name>A0A401NWV0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Fibroblast growth factor receptor</fullName>
            <ecNumber evidence="25">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">scyTo_0000409</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="25"/>
    <dbReference type="EMBL" id="BFAA01000076">
        <property type="protein sequence ID" value="GCB65340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWV0"/>
    <dbReference type="STRING" id="75743.A0A401NWV0"/>
    <dbReference type="OMA" id="RDINNDY"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005007">
        <property type="term" value="F:fibroblast growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05857">
        <property type="entry name" value="IgI_2_FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05101">
        <property type="entry name" value="PTKc_FGFR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000007">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000252">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000011">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016248">
        <property type="entry name" value="FGF_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF130">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000628">
        <property type="entry name" value="FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="13 25 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="19 28" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="21 29" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="22" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 25 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 25 30" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20 25" id="KW-0675">Receptor</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 32" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="18 25" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="34">
        <location>
            <begin position="90"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="34">
        <location>
            <begin position="204"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="34">
        <location>
            <begin position="307"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="33">
        <location>
            <begin position="531"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="31">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="26">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <begin position="537"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27 30">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="29">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="29">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="29">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="29">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="29">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="29">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="29">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="29">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="28">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="28">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="28">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRNR" id="PIRNR000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="GCB65340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="871" mass="97443" checksum="E5DB5E911F349694" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX06</accession>
    <name>A0A401NX06_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0004780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001434">
        <property type="protein sequence ID" value="GCB65395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX06"/>
    <dbReference type="STRING" id="75743.A0A401NX06"/>
    <dbReference type="OMA" id="KTERRVM"/>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000008">
        <property type="entry name" value="host cell factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043536">
        <property type="entry name" value="HCF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059124">
        <property type="entry name" value="Kelch_HCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003:SF1">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13854">
        <property type="entry name" value="Kelch_HCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Host cell factor Kelch-repeats" evidence="3">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="4">
        <location>
            <begin position="164"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="457" mass="51395" checksum="51C3D51E0D81C5E2" modified="2019-05-08" version="1" fragment="single">MAAPSPKWRRVTGATGPVPRPRHGHRVVAIKELMIIFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFICDGTRILVFGGMVEYGKYSNDLFELQASRWEWKKLKPKPPKNGPQPCPRLGHTLCLIGNKCYLFGGLANDSEDPKNNIPRILQPKKVEFMKKVRLTTKCKSEEKILVLTLWRAFLLPVRLPAKVEISFNYLEINAINAVDHTQVVIETEKLSHHLKLMSFEDLEQVVSHVTASLKKIFPDSSPGKLLKKNSPELQERIKKITSALDEQTNANQGPCGGYSETYAALCDYNGFPFKEEIQWDVDTIYHSQNTKEFNLLDFSHLDSRDVALSVAALAFNQWFTKLFSKDLRLSPDVIEQVLYVISLSSKLEELVLENAGMKFDAGQKIALALEENFHPVLHTVNLSNNQLEDRGVSALSQQFEKLSKGLKYLNLSRTSLTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY62</accession>
    <name>A0A401NY62_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid phosphatase related 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005600">
        <property type="protein sequence ID" value="GCB65811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY62"/>
    <dbReference type="STRING" id="75743.A0A401NY62"/>
    <dbReference type="OMA" id="HDQHAIL"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF14">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53581" checksum="0B80AC3E3147DF3E" modified="2019-05-08" version="1">MYFNSTISDCTKLLKPVLVFAFAIAAGICGLTQITQYRSHPVDVYVGFIFGAGIAAYLGFHAVGNFKASEDASPAKPPPKVGLRPLTHLRHDSVYQQSKSLSTDELNPQPRLDGLDHHLAQREKNSLNSLKRASVDVELLAPRSPMGKENMVTFSNTLPRVNTPNLDEAARRHMTIHVSMDASRSKQLISQWKQKSIDGMSLDHDPTISQSQPQMRTALELRGVGFDQDEPTPSSLYPTVQARNSERGSGARVLIQSRPGPSQLVHIPEETQGSVCTSPKSNSARAKWMLMAEKGGVPRPNNQPRIMQVIAMSKQQSMITVTPKHSDGSSSSESSHYKSPSERDSSSIVTVDAHGSHPIVHVSSGNGGVGPWEWKSPQGSADIHDAFELNDLNRDYRSYRSAKNSGISPGSSASDLEQEDARFCSVATINVAGAERSETNSETLTITSSRDSTLRRKPNPVFLGEREASTDTDQDAYFKKLQANRRFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYE9</accession>
    <name>A0A401NYE9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0000496</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000095">
        <property type="protein sequence ID" value="GCB65922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYE9"/>
    <dbReference type="STRING" id="75743.A0A401NYE9"/>
    <dbReference type="OMA" id="RFPKEEY"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF331">
        <property type="entry name" value="PROTOCADHERIN GAMMA SUBFAMILY C, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019208307" description="Cadherin domain-containing protein" evidence="13">
        <location>
            <begin position="24"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="128"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="345"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="450"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="566"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB65922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="727" mass="80132" checksum="7CD483F8C7BC03E5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P039</accession>
    <name>A0A401P039_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0007887</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionyl-tRNA(Leu) + H2O = tRNA(Leu) + L-methionine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77535"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:18931"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77536"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:11689"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01002938">
        <property type="protein sequence ID" value="GCB66473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P039"/>
    <dbReference type="STRING" id="75743.A0A401P039"/>
    <dbReference type="OMA" id="KPTCLME"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000326">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000084">
        <property type="entry name" value="Leucyl-tRNA synthetase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054509">
        <property type="entry name" value="LARS1_ULD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22947">
        <property type="entry name" value="ULD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="17">
        <location>
            <begin position="673"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="797"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="19">
        <location>
            <begin position="944"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase ubiquitin-like" evidence="18">
        <location>
            <begin position="1066"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB66473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1179" mass="134883" checksum="EEB1D5864957436B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P081</accession>
    <name>A0A401P081_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01004294">
        <property type="protein sequence ID" value="GCB66510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P081"/>
    <dbReference type="STRING" id="75743.A0A401P081"/>
    <dbReference type="OMA" id="QKAFKEW"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000003">
        <property type="entry name" value="NAD kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB66510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="452" mass="50379" checksum="4038939C7152CE22" modified="2019-05-08" version="1">MARPRKWHLQKMPEMEESRALEEPLDTEQGLGCLWSCGEELSGDSQLRGRAKSRSLSTSPALISGKVYRRTRSLHGPSPATKFGPKACMLQNPKAVMHIQDPASQRLTWSKPPKSILVIKKIQDHRLLQPFKDLCIFLMEEKDMIVYVEKKVLEDPTIADDESFGPLKKLSTFREGLDDLSDRIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFNFDTYQSQVTQVIEGNAAIILRNRLKVKVIKENWESKVGQEHPVEENGRIVAKHGENDLGKRAVQYQVLNEVVVDRGPSSYLSNVDLFLNGRLITSVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVDLQIMLSPDARNTAWISFDGRKRQEICHGDRINITTSCYPVPSICFRDPVNDWFDSLAECLHWNVRKKQSHLTDVEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P102</accession>
    <name>A0A401P102_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAA01001524">
        <property type="protein sequence ID" value="GCB66784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P102"/>
    <dbReference type="STRING" id="75743.A0A401P102"/>
    <dbReference type="OMA" id="WTEICGI"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000410">
        <property type="entry name" value="Serine/threonine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB66784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="13771" checksum="8532CD95DD59C78B" modified="2019-05-08" version="1">MEPSASKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSAYVVNYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTDKLGQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2N8</accession>
    <name>A0A401P2N8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ligand of Numb protein X 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0005114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001566">
        <property type="protein sequence ID" value="GCB67366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2N8"/>
    <dbReference type="STRING" id="75743.A0A401P2N8"/>
    <dbReference type="OMA" id="DTICGHT"/>
    <dbReference type="OrthoDB" id="438726at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16780">
        <property type="entry name" value="mRING-HC-C3HC3D_LNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06677">
        <property type="entry name" value="PDZ1_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06678">
        <property type="entry name" value="PDZ2_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06679">
        <property type="entry name" value="PDZ3_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06680">
        <property type="entry name" value="PDZ4_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000081">
        <property type="entry name" value="Ligand of Numb protein X 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000120">
        <property type="entry name" value="ligand of Numb protein X 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000120">
        <property type="entry name" value="Ligand of numb-protein X 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000164">
        <property type="entry name" value="Ligand of numb-protein X 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF33">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="275"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="379"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="510"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="642"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB67366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="81224" checksum="0ACF06B8C13CBEE1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P381</accession>
    <name>A0A401P381_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0008080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003029">
        <property type="protein sequence ID" value="GCB67546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P381"/>
    <dbReference type="STRING" id="75743.A0A401P381"/>
    <dbReference type="OMA" id="MTRFNTT"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF172">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="159"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="303" mass="34046" checksum="E1D606E504811A5F" modified="2019-05-08" version="1">MAGETIDGKVVLELNEPLFLYSVKLKIAGKGFVEWIGDSNENLDFTRKIHCSNREDYFHHIFTLWGSDYDAGGLEQTLEAGPHVFQFSHKLEDALPSSFNGSHGKIDYYVRAFCTAIDGTLAQVEKVLKVQETFNLNLDPSNKLPLLFTAEKEISYWCWRVPGIAMNVTVGKSGFVPGEDIIITSEIDNRTGKFIRLISYSIGTEIKYKAFVQEALCDHYREFIEKSELKKMEAVIEAPPRQFTKILGSLQLPKPMVVSDMSRCKIISITYELQVTIPIPAHRVSVTASVPIKIGTTPVHISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5A0</accession>
    <name>A0A401P5A0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar pre-ribosomal-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0010375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004459">
        <property type="protein sequence ID" value="GCB68283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P5A0"/>
    <dbReference type="OMA" id="DICLPEM"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="633"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1670"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB68283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2266" mass="258340" checksum="6BB06F660ECD568F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5R3</accession>
    <name>A0A401P5R3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAG family molecular chaperone regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0005307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001638">
        <property type="protein sequence ID" value="GCB68474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5R3"/>
    <dbReference type="STRING" id="75743.A0A401P5R3"/>
    <dbReference type="OMA" id="HSECNEK"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01812">
        <property type="entry name" value="Ubl_BAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017093">
        <property type="entry name" value="BAG-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037029">
        <property type="entry name" value="BAG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="5">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="95"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB68474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="207" mass="22784" checksum="203CCAD16373936F" modified="2019-05-08" version="1">MAGDGVGLTLMHGSSKHKIEISAGQEGCEPTLQDMATVIAQVTGVPQQLQKLIFKGKSLKEMEQPLSVLGVKNGCKIMMIGKKNSPEEEAELKKLKELEKSTDQLSHKLEEINAELTGIQNGFLARDLQSAALSKLEKKVKSTSEQCMKFLEQIDAMSLPDDFSDCRHRRKGLVKNVQTYLAQCDVIGTNISQELEKLQSKNLALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5S3</accession>
    <name>A0A401P5S3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0000887</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000183">
        <property type="protein sequence ID" value="GCB68484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5S3"/>
    <dbReference type="STRING" id="75743.A0A401P5S3"/>
    <dbReference type="OMA" id="HINVAVR"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB68484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="14411" checksum="0270C9BF3D47F546" modified="2019-05-08" version="1">MSGHGKTRGKGCTEAKTRFFWADLLFTIGCIYRLLRKGHYAQRMGTSTPAYPAVVLEYQTAEILELNVNVAWDNTKTHTIPHHLQLTIRNGTKLNKLLGRLTITQGGILPNIQAVLLPRETGHPSKVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6Z0</accession>
    <name>A0A401P6Z0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Testican-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0005380</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May participate in diverse steps of neurogenesis. Binds calcium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001667">
        <property type="protein sequence ID" value="GCB68902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6Z0"/>
    <dbReference type="STRING" id="75743.A0A401P6Z0"/>
    <dbReference type="OMA" id="ESKHEGC"/>
    <dbReference type="OrthoDB" id="8875634at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000101">
        <property type="entry name" value="SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000003">
        <property type="entry name" value="SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000001">
        <property type="entry name" value="Testican-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF18">
        <property type="entry name" value="TESTICAN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019370605" description="Testican-2" evidence="16">
        <location>
            <begin position="41"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="18">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="323"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB68902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="437" mass="48904" checksum="9A6E97E2E611E711" modified="2019-05-08" version="1" fragment="single">YNQLAFHSSQPAGSVASPRGPGRMLKQLNLLLIPLLLAAAAEEERPEKGGDNKGNFLEDEQWLSGVSHYSRQIKDWNRFRDEVEDDYIRSWDQKPFDEALDPTKDPCQKVKCSRHKVCVSQGQLRAMCISHKKLQHRIKQSSVGHGESACKPCLTVQTSPVCGSDGHTYSSQCKLELQVCLTGKQLSQECEGKCPCPTKHTPTSDRRSKSAGCTGQDLADLGDRLRDWFQLLHENAKQNGSGRFGSAPGVLDKSLVASCRDSIGWMFNKLDTNVDLFLDEAELAAINLDKYEVCVRPFFNSCDTYRDGHVSMAEWCFCFWREKPPCLAELEKIQLQEAVRKVPGIFIPSCDEDGYYRKVQCNTYSGECWCVDQQGGEVTGTRVKGNPDCDELVSFSGDFGSGVGWEDEEEKETEETAEETEEEEGEVGETDDGGYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P760</accession>
    <name>A0A401P760_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0008306</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003150">
        <property type="protein sequence ID" value="GCB68948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P760"/>
    <dbReference type="STRING" id="75743.A0A401P760"/>
    <dbReference type="OMA" id="HQAKKSC"/>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CYCLIN_CCNF_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20522">
        <property type="entry name" value="CYCLIN_CCNF_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22082">
        <property type="entry name" value="F-box_FBXO1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 14" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="16">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="752"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB68948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="787" mass="89027" checksum="59C7E47EE9A2F714" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P861</accession>
    <name>A0A401P861_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000216">
        <property type="protein sequence ID" value="GCB69308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P861"/>
    <dbReference type="STRING" id="75743.A0A401P861"/>
    <dbReference type="OMA" id="RCERHEH"/>
    <dbReference type="OrthoDB" id="6380629at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF958">
        <property type="entry name" value="COLLAGEN ALPHA-1(I) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="61228" checksum="BE0D22AE366E83DD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8H1</accession>
    <name>A0A401P8H1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine-rich DPF motif domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0010557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004580">
        <property type="protein sequence ID" value="GCB69437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8H1"/>
    <dbReference type="STRING" id="75743.A0A401P8H1"/>
    <dbReference type="OMA" id="CRRAVCH"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042426">
        <property type="entry name" value="CDPF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018785">
        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849:SF1">
        <property type="entry name" value="CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849">
        <property type="entry name" value="CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10170">
        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01995">
        <property type="entry name" value="UPF0595"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich DPF motif" evidence="3">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB69437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="136" mass="15482" checksum="62651092B3AD6B6A" modified="2019-05-08" version="1">MPYSPAAGQRIIEVPVPVRKMQSVEEPEGVFECRLCGLRAPYSYHGQKPPNACSVVLLEECYTMNDPFTPQKDRFLILGSHCCLCNNAVCVGQDCSLFYAKRFCIPCVKEHIDKFPEEIQLDLQKKKQQQNLQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB14</accession>
    <name>A0A401PB14_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin-related family member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Photoreceptor cadherin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protocadherin-21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0010747</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004692">
        <property type="protein sequence ID" value="GCB70299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB14"/>
    <dbReference type="STRING" id="75743.A0A401PB14"/>
    <dbReference type="OMA" id="NMIDAQD"/>
    <dbReference type="OrthoDB" id="6510378at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000111">
        <property type="entry name" value="Cadherin-related family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000113">
        <property type="entry name" value="Cadherin-related family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000122">
        <property type="entry name" value="Cadherin-related family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000126">
        <property type="entry name" value="Cadherin-related family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF413">
        <property type="entry name" value="CADHERIN RELATED FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0732">Signal</keyword>
    <keyword evidence="2 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019278928" description="Cadherin-related family member 1" evidence="16">
        <location>
            <begin position="24"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="237"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="351"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="456"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB70299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="737" mass="81565" checksum="88445A3FD6EF34DA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB29</accession>
    <name>A0A401PB29_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="BFAA01003300">
        <property type="protein sequence ID" value="GCB70324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB29"/>
    <dbReference type="STRING" id="75743.A0A401PB29"/>
    <dbReference type="OMA" id="MVKLLWK"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000004">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="116"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB70324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="463" mass="53544" checksum="81D5D2A1BA4542EC" modified="2019-05-08" version="1">MQAKLTHNKRERSQIGGGTANIQELSKFEENAAELTREDRDHSCGEGNARVRGQAGLLSERRGSYPVIDFRLLNTTAHSGEIGTKKRVKRLLSFQRYFHASRLLRGIVPQTCLHLLDEDYLGQARHMLSKVGRWNFDIFLFDRLTNGNSLVTLLCHLFNLHGLIHHFQLDMVKLHRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLSRFLSPLDIMLGLMAAAAHDVDHPGVNQPFLIKTKHHLANLYQNISVLENHHWRSTVGMLRESGLLAHLPVESIQDVEQQLGSLILATDISRQNEFLARMKTHSDNRDLSLEDADHKHFILQIALKCADICNPCRVWNMSKQWSEKVCEEFYRQGDLEQRFQFEVSPLCNQQNDTIPSIQIGFMSYIVEPLFMEWSRFTENTPLTITMMSHLRKNKARWRGLLLKQHNSEDNSAQMNEDKSRTSQEVEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBD0</accession>
    <name>A0A401PBD0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome non-ATPase regulatory subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">26S proteasome regulatory subunit RPN3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">26S proteasome regulatory subunit S3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Proteasome subunit p58</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0001278</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD3, a base containing 6 ATPases and few additional components. Interacts with UBQLN1 (via ubiquitin-like domain). Interacts with ERCC6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000279">
        <property type="protein sequence ID" value="GCB70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBD0"/>
    <dbReference type="STRING" id="75743.A0A401PBD0"/>
    <dbReference type="OMA" id="AKLWFYI"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000174">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PCI" evidence="13">
        <location>
            <begin position="292"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB70428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="540" mass="61744" checksum="DE0B61C743784269" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBP8</accession>
    <name>A0A401PBP8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008607</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003334">
        <property type="protein sequence ID" value="GCB70547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBP8"/>
    <dbReference type="STRING" id="75743.A0A401PBP8"/>
    <dbReference type="OMA" id="CIYVANI"/>
    <dbReference type="OrthoDB" id="8920197at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05716">
        <property type="entry name" value="IgV_pIgR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000357">
        <property type="entry name" value="Fc receptor like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050671">
        <property type="entry name" value="CD300_family_receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860:SF87">
        <property type="entry name" value="CMRF35-LIKE MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860">
        <property type="entry name" value="POLYMERIC-IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB70547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="392" mass="43550" checksum="B1165C54888B6859" modified="2019-05-08" version="1" fragment="single">ALWAERKVRGIVGRAITIHCHYDAGYKSYIKFWCHGTTIHCKVLAQTNWQNGRFSITDNKSQTTFVVTVDDLRPADAGWYSCGIERNGLDPMFSVEIKTSYESVSVPVLKFLSPLNVSCSGGSVTVSCESVRGSLPIQYTWNEKTPSEDSKISDTKELDLRCQSLKQQQHQYYCTASNNQGEQSSEMVNVSVINSSEQSCSYVILFGNSGPEYSCEVSSTESPTSTHSTRRSSSSKQSESSDSKNDESLIYIVLGVLGAFLIVFVASLLLYLRQINKGSNGILCHRRDKALHDDQQLAAEEENIVYADINHIDRNSARTDREGTVQLTNDGITYAAVQFQKKPSRRSNEVSRHSAYNMDGAIYSNITIQSQSKGNPKTPQESEMSTYASVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC15</accession>
    <name>A0A401PC15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Phosphomannomutase</fullName>
            <ecNumber evidence="6 11">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="6 11"/>
    <dbReference type="EMBL" id="BFAA01001834">
        <property type="protein sequence ID" value="GCB70661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC15"/>
    <dbReference type="STRING" id="75743.A0A401PC15"/>
    <dbReference type="OMA" id="SIXGGND"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000216">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF2">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB70661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="230" mass="26028" checksum="6ECACC24B3E0B641" modified="2019-05-08" version="1">MAAEERECSSGGTLCLFDVDGTLTEARQKITPDMAEFTERLREKVKVGVVGGSDFAKIKEQLGDEVVSSFDYVFAENGLVAYKAGKFLAKQNILSKNILGTFIEFRNGMLNISPIGRNCSQEERIEFFELDKKEKIRENFVADLRREFAGRFLTFSIGGQISFDVFPEGWDKRYCLGLLESDNYKTIHFFGDKTSPGGNDYEIFSDARTIGHSVTSPDDTRRICDELFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC55</accession>
    <name>A0A401PC55_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0010836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CREG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004759">
        <property type="protein sequence ID" value="GCB70702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC55"/>
    <dbReference type="STRING" id="75743.A0A401PC55"/>
    <dbReference type="OMA" id="AQTPYCR"/>
    <dbReference type="OrthoDB" id="46836at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000004">
        <property type="entry name" value="Cellular repressor of E1A-stimulated genes 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF21">
        <property type="entry name" value="PROTEIN CREG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="6">
        <location>
            <begin position="45"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB70702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="224" mass="24846" checksum="98FF0C904FBE914C" modified="2019-05-08" version="1">MIAGRCAPARAGRRHCQSVGLTMLRCEFALLLVLFTFLRGSSSIPPHDEVARMARYIVHACDWGSVATISTHPAVGGRPFSNIFSVSDGPLGKGSGHPYLYLTPLDISVKDMQVNAEVSLAMSLAETGYCKKQKFDPESPLCCRVILSGAIMMVNKTEINFAKEALFSRHPAMPDWPHDHGWYFAKLNITNIWVLDYFGGIKTVTPEEYYSVKPEYEGNGEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDI5</accession>
    <name>A0A401PDI5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0010944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004833">
        <property type="protein sequence ID" value="GCB71183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDI5"/>
    <dbReference type="STRING" id="75743.A0A401PDI5"/>
    <dbReference type="OMA" id="ECEAIND"/>
    <dbReference type="OrthoDB" id="10045578at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003989">
        <property type="entry name" value="VCAM-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF218">
        <property type="entry name" value="MICROFIBRILLAR-ASSOCIATED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01474">
        <property type="entry name" value="VCAM1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019017800" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="303"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="391"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="479"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="564"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB71183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="705" mass="75752" checksum="D64FDB875263B50E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE58</accession>
    <name>A0A401PE58_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0005924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01001924">
        <property type="protein sequence ID" value="GCB71385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE58"/>
    <dbReference type="STRING" id="75743.A0A401PE58"/>
    <dbReference type="OMA" id="YHDVNTH"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF16">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="385" mass="44224" checksum="419B6727228412D6" modified="2019-05-08" version="1">MAGPVPSRARVYTDVNTHKPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLIDIVKDPVSRTPALVFEHVNNTDFKCTNNGRMVFLCLQALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSSEALDFLDKLLRYDHQTRLTAREAMEHPYFYPIVKDQSRMGSCANMPTGSTPISSASMMSGISAMPTSSPLGPLAGSPVISATNTLGTPVPATAGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PED7</accession>
    <name>A0A401PED7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complement component C8 beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Complement component 8 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">scyTo_0001591</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Heterotrimer of 3 chains: alpha (C8A), beta (C8B) and gamma (C8G); the alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC), composed of complement C5b, C6, C7, C8A, C8B, C8G and multiple copies of the pore-forming subunit C9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complement C6/C7/C8/C9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000364">
        <property type="protein sequence ID" value="GCB71486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PED7"/>
    <dbReference type="STRING" id="75743.A0A401PED7"/>
    <dbReference type="OMA" id="KYYAGAC"/>
    <dbReference type="OrthoDB" id="6150863at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005579">
        <property type="term" value="C:membrane attack complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006957">
        <property type="term" value="P:complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048831">
        <property type="entry name" value="C8A_B_C6_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001862">
        <property type="entry name" value="MAC_perforin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742">
        <property type="entry name" value="COMPLEMENT COMPONENT C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742:SF5">
        <property type="entry name" value="COMPLEMENT COMPONENT C8 BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21195">
        <property type="entry name" value="EGF_C8A_B_C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00764">
        <property type="entry name" value="COMPLEMENTC9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0179">Complement alternate pathway</keyword>
    <keyword evidence="15" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="13" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="18 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0473">Membrane attack complex</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 26" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="21" id="KW-1053">Target membrane</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019479234" description="Complement component C8 beta chain" evidence="26">
        <location>
            <begin position="31"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="27">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00093472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="GCB71486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="511" mass="57193" checksum="94C13A14B66FD038" modified="2019-05-08" version="1">MLKTYKMMLQSVNCILLYVALGIIQPNVYCRETLAESNDQSNVVNINKVGGHWKRSLRNPSQPIDCILSSWSSWSICDPCQNKRYRYARLEVPSQFGGVSCNSFDREEKSCTAGPCRTRSLCEGFVCAITGRCVPRRLRCNEDDDCGDQSDEEGCRRVSNACSRQTEPYWAAQHIGSGYNILTGTPEGTVLDNRYYGGSCAPYYINNVRFRKPYNLEFYSPETKGKFELSLSEHESYSNFTHSRFESETKRVDFKLATSFPSVFELGVGYNSNNYKKMMTKLLKNSASVSYTLNDAKDCSKAGFNVGAFIEVAYAAVDFSVGGCNGLLNLNQGGISQSNYTEDFIVFVRGGASEHVTTLAHKQIPTVELMQEWGDAVEYNPEVIKFKPVPLYELVTSNTFQNAYRIKANMRQALEEYLIEASSCRCAPCRNNGVAVLRGTRCVCICPAGFRGTACEITSREDQAVDGKWSCWSSWSGCTKRQRTRTRQCNNPPPEKGGQTCKGDSQHILSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PEN1</accession>
    <name>A0A401PEN1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HIRA-interacting protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0001624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer and homohexamer; the apo-NFU1 is a monomer, while the holo-NFU1 is a hexamer composed of a trimer of dimer that is probably linked by some 4Fe-4S cluster. Interacts with HIRA and EPM2A/laforin. Interacts with BOLA3. Interacts with HSPA9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000372">
        <property type="protein sequence ID" value="GCB71583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PEN1"/>
    <dbReference type="STRING" id="75743.A0A401PEN1"/>
    <dbReference type="OMA" id="IFEHIME"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000002">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="12">
        <location>
            <begin position="57"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB71583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="248" mass="27149" checksum="C63B9FF3EF29C8C7" modified="2019-05-08" version="1">MAAVKLGLYLILASRKPTGRLVKCLSCTRRWSGNGPGYQKTLRPSPAFCIPSRSMFIQTQDTPNPNSLKFIPGCPVLESGTMDFSAPRSAFCSPLARQLFRIDGVKGVFLGPDFITVTKADGEVEWKLLKPDVYATIMDFFASGLPILTDEAPRSDTAPSEEDDEVVAIIKELLDTRIRPTVQEDGGDVIYKGFEDGIVKLMLQGSCTSCPSSIITLKSGIQNMLQFYVPEVEGVVQVKEEEQDADST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF40</accession>
    <name>A0A401PF40_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0006045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001973">
        <property type="protein sequence ID" value="GCB71708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PF40"/>
    <dbReference type="STRING" id="75743.A0A401PF40"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035497">
        <property type="term" value="F:cAMP response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46004">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46004:SF1">
        <property type="entry name" value="CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB71708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="14831" checksum="CF7DB068D939B82B" modified="2019-05-08" version="1">MDILDNFGAEKLFAASSLVDLEDLNEADFLSNVHFSENLDDFSNELFSSFFDDPLLAEKNPLLDMDLDPATPDIQADHSYSLSGDSAPQSPVMPIKMDEFSKGKGGFTWVRDRIDSLLHAYTYMMGFTLFTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFX4</accession>
    <name>A0A401PFX4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0006152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002024">
        <property type="protein sequence ID" value="GCB72040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFX4"/>
    <dbReference type="OrthoDB" id="10407255at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB72040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="68" mass="7848" checksum="E1D8DADC140CA8C7" modified="2019-05-08" version="1">MLGAHWIFEDKYEIICMLSLGRRWNGAEGFVFCCLLGTGEICLQSHHLCQKNMQIRCSPDIIQAWGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG83</accession>
    <name>A0A401PG83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PR domain zinc finger protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0009035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003590">
        <property type="protein sequence ID" value="GCB72142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG83"/>
    <dbReference type="STRING" id="75743.A0A401PG83"/>
    <dbReference type="OMA" id="YNEEASC"/>
    <dbReference type="OrthoDB" id="9998363at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19197">
        <property type="entry name" value="PR-SET_PRDM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000616">
        <property type="entry name" value="PR domain zinc finger protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000743">
        <property type="entry name" value="PR domain zinc finger protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044407">
        <property type="entry name" value="PRDM13_PR/SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF21">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="568"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB72142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="69404" checksum="AD152EDC62C40AB1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGQ9</accession>
    <name>A0A401PGQ9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0006239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GW182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002070">
        <property type="protein sequence ID" value="GCB72301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGQ9"/>
    <dbReference type="STRING" id="75743.A0A401PGQ9"/>
    <dbReference type="OMA" id="YANSAWG"/>
    <dbReference type="OrthoDB" id="5919166at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035195">
        <property type="term" value="P:miRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12712">
        <property type="entry name" value="RRM_TNRC6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000011">
        <property type="entry name" value="trinucleotide repeat-containing gene 6A protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019486">
        <property type="entry name" value="Argonaute_hook_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052068">
        <property type="entry name" value="GW182_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032226">
        <property type="entry name" value="TNRC6_PABC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034925">
        <property type="entry name" value="TNRC6B_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020">
        <property type="entry name" value="TRINUCLEOTIDE REPEAT-CONTAINING GENE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020:SF32">
        <property type="entry name" value="TRINUCLEOTIDE REPEAT-CONTAINING GENE 6B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10427">
        <property type="entry name" value="Ago_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16608">
        <property type="entry name" value="TNRC6-PABC_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Argonaute hook" evidence="7">
        <location>
            <begin position="359"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="TNRC6 PABC binding" evidence="8">
        <location>
            <begin position="753"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="838"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="958"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="848"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="901"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="912"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="967"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="984"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB72301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1210" mass="130014" checksum="AA41AD83E4005480" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHK3</accession>
    <name>A0A401PHK3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Voltage-dependent L-type calcium channel subunit beta-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Calcium channel voltage-dependent subunit beta 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0006382</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2. Interacts with CACNA1C. Interacts with RRAD; interaction may be involved in beta-adrenergic regulation of heart rate and contractile force. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane. Interacts with TMIGD2. Interacts with CAMK2D. Interacts with CBARP. Interacts with CAMK2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002138">
        <property type="protein sequence ID" value="GCB72591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHK3"/>
    <dbReference type="STRING" id="75743.A0A401PHK3"/>
    <dbReference type="OMA" id="DSNFSHH"/>
    <dbReference type="OrthoDB" id="5962384at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000015">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000023">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005444">
        <property type="entry name" value="VDCC_L_b2su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01628">
        <property type="entry name" value="LCACHANNELB2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="8" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="444"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB72591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="616" mass="69251" checksum="39284BE18E55574B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIR7</accession>
    <name>A0A401PIR7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex subunit EXOC6/Sec15 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0002311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000571">
        <property type="protein sequence ID" value="GCB73030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIR7"/>
    <dbReference type="STRING" id="75743.A0A401PIR7"/>
    <dbReference type="OMA" id="WATANTH"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000001">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000001">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF3">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="4">
        <location>
            <begin position="142"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB73030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="493" mass="57145" checksum="BA4C065328F941DF" modified="2019-05-08" version="1">MVLSAQDLVDFSPVYRCLHIYTALGAQDTFENYYRKQRKKQARLVLQPPSNMHETLDGYRRYFNQIVGFFVVEDHILHTTQRLVNRAYIDQLWELAVSKTMSALRTHSSYCSDPNLVLDLKNLLVLFADTLQGYGFPVNQYFDMLLEIRDQYGEILLKKWSGVFRYILDLDNYSAIPVSSEEEYMRVMGQFPFHDPELENQSFPKKFPFSEFVPKVYTQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNCLQNVIKKQHVGLTELVQIIINTTHLERSCKFLEEFITNITNVPPETIHATKLYGTATFKDCRHAAEEEIYTKLNQKIDQFLQLADYDWMRAEHNGHASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLSTSLLQLLLDTEVKQITMGALKQFNMDIEECEHFARSGPVPGFQGDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPTTALILLDKISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIX8</accession>
    <name>A0A401PIX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin-binding protein cabin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin inhibitor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002253">
        <property type="protein sequence ID" value="GCB73048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PIX8"/>
    <dbReference type="OMA" id="MEALEXE"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000654">
        <property type="entry name" value="Calcineurin-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000076">
        <property type="entry name" value="calcineurin-binding protein cabin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1307"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB73048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1373" mass="155833" checksum="1B5AF65634974F30" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKY1</accession>
    <name>A0A401PKY1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0002847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="BFAA01000733">
        <property type="protein sequence ID" value="GCB73765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKY1"/>
    <dbReference type="STRING" id="75743.A0A401PKY1"/>
    <dbReference type="OMA" id="HIIEYVI"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000106">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="373"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB73765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="462" mass="51608" checksum="6191CC278F349314" modified="2019-05-08" version="1">MADVAEPEKKRRKVEEHTDKMAVDGGYGDTGDWDGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLETCKVLVIGAGGLGCELLKNLALMGFRRIDVIDMDTIDVSNLNRQFLFRPKDVGRPKAEIAAEFINSRIPDCSVVPHFKKIQDFSETFYRQFHIVISGLDSIIARRWINGMLISLLNFEDGTLDPSSIIPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQINFPMCTIASMPRLPEHCIEYVRILQWPKESPFGEGVALDGDDPEHIQWAFQKSLERAAQFNITGISYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIASSAYIPLNNYLVFNDVDSLYTYTFEAERKENCPACSQVPQDLQFPSSAKLQELLDYLTQSTSLQMKSPAITATLDGKNKTLYLQTVASIEERTRPNLSKTLKELGLTNGQELAVADITTPQTVLFKLHFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMK2</accession>
    <name>A0A401PMK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0003414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000921">
        <property type="protein sequence ID" value="GCB74325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMK2"/>
    <dbReference type="OMA" id="KDYWVSP"/>
    <dbReference type="OrthoDB" id="9940994at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="169" mass="20439" checksum="0A4BCE5772B03E6D" modified="2019-05-08" version="1" fragment="single">FKKYPRETHRESGMTYAYTPRHKIVLDNIRRRDPLMKDYWVSPHKLDAADTTDRLSRSHYLRLPRYRNHLEFESLTYPSYFDYKQRMLVQYPMLKKTWRSNLGSVILDTFRRSRFGLQDYWSNPQRAYYIGSVSRDSRRHLLVLPGNTGISDVDSTIKPGYFHYRHKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PN72</accession>
    <name>A0A401PN72_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0003650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001017">
        <property type="protein sequence ID" value="GCB74559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PN72"/>
    <dbReference type="STRING" id="75743.A0A401PN72"/>
    <dbReference type="OMA" id="WANFLAN"/>
    <dbReference type="OrthoDB" id="6761011at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="152"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB74559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="281" mass="32089" checksum="F83298537757E7A3" modified="2019-05-08" version="1">MGRMVDQYRLRATFPYLDNVTICGHDQQDHDANLQHFLHTAKLLNLTIRRNAFSAQPAEPSLATSWKMESEGPTPTACALSWKFHSPHCPKELKRCLGFFSYYAQWVPNYVDKARPLIKSTIFPLTAEARQAFNHIKTDIAKAAMHAVDESISFQVENDASDFALATTLNQAGRPVAFFSRTLLASEIRHSSVEKETQAIVDAMRHWRHYLAGRRFTPLTDQRLVAFMFNNTQRGKVKNDKILRWRIELSTYNYDILYRPGKLNEPPEALSRGSCASAQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PND9</accession>
    <name>A0A401PND9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0003724</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01001047">
        <property type="protein sequence ID" value="GCB74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PND9"/>
    <dbReference type="STRING" id="75743.A0A401PND9"/>
    <dbReference type="OMA" id="HSEICGM"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000055">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF62">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019474657" description="receptor protein serine/threonine kinase" evidence="22">
        <location>
            <begin position="26"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="24">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="173"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="471" mass="53766" checksum="0B82D04C07A6BF63" modified="2019-05-08" version="1">MVWLADPSWQILVSLITLLSLQIEGNRLDNMLLRSTGKLSIDNKKGYVDSTDTPKSSQRRAIECCTDRDFCNRDLHPTLPPQDMRDFVDGNSHHIPLLISVTVCSIILALLIIFCYFRYKRQEDRPHYNMGIEQDETFIPPGESLKDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGRWRGEKVAVKVFFTMEEASWFRETEIYQTVLMRHDNILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKAMLKLAYSTVSGLCHLHTEIFGTQGKPAIAHRDLKSKNILVKKNGMCCIADLGLAVKFISDTNEVDIPLNTRVGTKRYMAPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVSVGIVEEYQLPYHDLVPSDPSFEDMREVVCIKQLRPSFPNRWTSDECLRQMGKVMAESWAHNPASRLTALRVKKTLAKMSESQDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PNG6</accession>
    <name>A0A401PNG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger transcription factor Trps1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0003712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001039">
        <property type="protein sequence ID" value="GCB74621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PNG6"/>
    <dbReference type="OMA" id="YESCHSM"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000020">
        <property type="entry name" value="Zinc finger transcription factor Trps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028440">
        <property type="entry name" value="TRPS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47034">
        <property type="entry name" value="ZINC FINGER TRANSCRIPTION FACTOR TRPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47034:SF1">
        <property type="entry name" value="ZINC FINGER TRANSCRIPTION FACTOR TRPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="907"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="77"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="466"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="724"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="827"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="965"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="786"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1077"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB74621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1296" mass="142493" checksum="F6BD3788B93295EE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP99</accession>
    <name>A0A401PP99_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0018144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012357">
        <property type="protein sequence ID" value="GCB74966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP99"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB74966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="98" mass="11184" checksum="B5793E2C1726D77D" modified="2019-05-08" version="1">MKNAFPRLPHAFSSIIDFAVNTASRMLNWFGDMLGKGKYLKYVKIDHLVGIGAYEDRNEKLKHLPTSRLEAVPKDEHFLCQCISPSLWFSLGKASLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ55</accession>
    <name>A0A401PQ55_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016309">
        <property type="protein sequence ID" value="GCB75261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ55"/>
    <dbReference type="OrthoDB" id="8956691at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="214" mass="23619" checksum="175ECF5FD71F1C30" modified="2019-05-08" version="1" fragment="single">SDEANLSSDNSSPSQSPQVSWEPSKAKSHLTPGSPVKTGIPLGKLGSNKDLLPRRSPSFRLKQSSSTNLSAQRGEGQLDSCRNNNTMLGMNKARDPNAASNSTGDEQSVSAPPEKPSHTYYNIHPYPEGGEQKDLGLSTGTRQILGSTPNLCVERRHPDLSMSREVCESRRKTWEPASTETPNTFAMPTWHHTQDTESRKKKDKNVFKKLFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQ80</accession>
    <name>A0A401PQ80_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thrombospondin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0015291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008613">
        <property type="protein sequence ID" value="GCB75281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQ80"/>
    <dbReference type="STRING" id="75743.A0A401PQ80"/>
    <dbReference type="OMA" id="HRFRMEM"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB75281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="388" mass="41839" checksum="96F8D5EECE52566D" modified="2019-05-08" version="1" fragment="single">DVFPQGLPDEYAFVATFKFRKASRREDWYIWQIIDKYGIPQVSIRLDGENKAVEYNAVGLRKDAVRTVFKNREVSGLFDRNWHKMALSIQTSSVSLYIDCKLIETLPMEERENINIRGKTVIGKRLYDSVPIDFDLQRIVIYCDAKDTELESCCDLPSNPCQITLATQVPQVEISTTPQPPAEVDSSKTINCSCHQGEKGDLGLPGFQGPRGPKGDTGAYGPKGEKGESKDGTELGQFRWDIFKFTLMMALEEALLITFFIFQGRISDTSQGKGEKGDQGYPGEQGFKGVAGTPGVKGERGQKGFGGDKGVRGFDGFPGKIGLPGEVGATGSPGASGVKGEKVEFGGLKGEPGQLGPRGLPGLTGPPGPMGRPGLDGNAGKPGLQGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQE1</accession>
    <name>A0A401PQE1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endothelin-like toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0020352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endothelin/sarafotoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016326">
        <property type="protein sequence ID" value="GCB75341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQE1"/>
    <dbReference type="STRING" id="75743.A0A401PQE1"/>
    <dbReference type="OMA" id="FLDKECI"/>
    <dbReference type="OrthoDB" id="9362154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031708">
        <property type="term" value="F:endothelin B receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003100">
        <property type="term" value="P:regulation of systemic arterial blood pressure by endothelin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019229">
        <property type="term" value="P:regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014826">
        <property type="term" value="P:vein smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020475">
        <property type="entry name" value="Endothelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019764">
        <property type="entry name" value="Endothelin_toxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001928">
        <property type="entry name" value="Endothln-like_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13874">
        <property type="entry name" value="ENDOTHELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00322">
        <property type="entry name" value="Endothelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00365">
        <property type="entry name" value="ENDOTHELIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00272">
        <property type="entry name" value="END"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00270">
        <property type="entry name" value="ENDOTHELIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0838">Vasoactive</keyword>
    <keyword evidence="5" id="KW-0839">Vasoconstrictor</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019005179" description="Endothelin-like toxin domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Endothelin-like toxin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Endothelin-like toxin" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB75341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="24903" checksum="9AB0B08C712AA45B" modified="2019-05-08" version="1">MEFNVLFSLLPLMWELHFSTGSPLSAAALTVSPITSAGQTSSSVPRRLSRSKRCSCSSFLDKECIYFCHLDIIWINTPERIVPYGLGNSPRVRRSVKKNLATPRCQCRSQEDTVCWQFCEGGQQTSRFSSKTKVQKNYLEEASDRMSRNKQDCKGLKCVYQHLLNIAKKLEPADSNHLPTSVKWIYTIRKVRQDSYNKLKRLPVSMTGPVAECRDCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQH3</accession>
    <name>A0A401PQH3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011178">
        <property type="protein sequence ID" value="GCB75371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQH3"/>
    <dbReference type="STRING" id="75743.A0A401PQH3"/>
    <dbReference type="OrthoDB" id="10043757at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF8">
        <property type="entry name" value="PROTEIN SPIRE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="170" mass="19606" checksum="1EFD3A056E86F47D" modified="2019-05-08" version="1" fragment="single">LCFCCRTKRFSIFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSNLPIFSLGPSTLPKEGKVLKPEKPSSSRRRHDGQHKSLVRLPSMSKSSEKSTDSLEFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYLSSTSTSEFRLAAPKERTIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQZ4</accession>
    <name>A0A401PQZ4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0020923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01017656">
        <property type="protein sequence ID" value="GCB75517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQZ4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="116" mass="12321" checksum="999A5EBCA91D342C" modified="2019-05-08" version="1">MTGGGAIHSAPPPAAAWQPPPFQTGAFSRASWQRSSIDRPAGQDEGAAGLPPRLELPRLEAGLAAVRGRKGQQQLAAAERPLRRPAGLQQPDRVQRTAGARPAGYRLLVQLWADCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PRE4</accession>
    <name>A0A401PRE4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0020937</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in sperm motility, especially in the regulation of flagellar function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01017693">
        <property type="protein sequence ID" value="GCB75681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PRE4"/>
    <dbReference type="STRING" id="75743.A0A401PRE4"/>
    <dbReference type="OMA" id="RHKYNEV"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF28">
        <property type="entry name" value="MAP_MICROTUBULE AFFINITY-REGULATING KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB75681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="401" mass="44465" checksum="AA381B33A8887F53" modified="2019-05-08" version="1" fragment="single">MKCLNHPNIVKLFEVIETEKTLYLVMEYASGAGLRGLMFVQSRVRIDGGLTCFQIVSAVQYCHQRNIVHRDLKAENLLLDGDCNIKIADFGFSNEFQFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCENILKRFLVLNPAKRGTLEQIMKDKWINVGCDGEELRPYVEPEQDLGDSKRIEVMVGMGYTREEIKEALTRHKYNEVTATYLLLGRNKSEMDGTDSRSGSSLSLAKVRPSNELNTSTASQTSTHSRSQRSSSTYHRQRRHSDFSGPAALTSHPKRSQTSTADNDLKEERIPLRKTTAGGGGGAVTSSSTSSSTSSRAGAPPSSPMVSSANNPNKSEIPDRRKVTGPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PUX7</accession>
    <name>A0A401PUX7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0019214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014069">
        <property type="protein sequence ID" value="GCB76931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PUX7"/>
    <dbReference type="STRING" id="75743.A0A401PUX7"/>
    <dbReference type="OMA" id="MEERTMD"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="137" mass="16297" checksum="D6FDF9450C1FABA6" modified="2019-05-08" version="1">MEQRAVDIPLYMEQRAVDIPLYMEQRAVDIPLYMEQRAVDIPLYMEERAVDIPLSMEQRAVDIPLSMEQTAVDIPLYMEQRAVDIPLYMEQRAVDIPLYMEQRAVDIPLYMEQRAVLIPLYMEERTMDIPFLWNRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PW59</accession>
    <name>A0A401PW59_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="4">2.3.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0017588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01011557">
        <property type="protein sequence ID" value="GCB77342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PW59"/>
    <dbReference type="STRING" id="75743.A0A401PW59"/>
    <dbReference type="OMA" id="SIHITEP"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042541">
        <property type="term" value="P:hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000029">
        <property type="entry name" value="5-aminolevulinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF58">
        <property type="entry name" value="5-AMINOLEVULINATE SYNTHASE, ERYTHROID-SPECIFIC, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="84"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB77342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="281" mass="31507" checksum="AA3CC0C66AE252B0" modified="2019-05-08" version="1">MNLEIRLYVRSAPEVCSSKENSSGCEIYSDAGNHASMIQGIRNSGIPKFVFRHNDVEHLEQLLRESDPRAPKIVAFETVHSMDGKAFGCVGGYIASTAALTDTIRSYAAGFIFTTALPPMVLAGALESVRTLKSEEGQALRRSHQRNVKYMRQLLMDAGLPVIKCPSHIIPIRVCDAARNTEICNIMMSRHDIYVQAINYPTVPRGEELLRLAPSPHHEPRMMEYFVDCLVEAWKEVGLPMQSLSSATCSFCQRPLHFELMSEWERSYFGGMEGRYLTVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWM9</accession>
    <name>A0A401PWM9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MCM AAA-lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011597">
        <property type="protein sequence ID" value="GCB77537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWM9"/>
    <dbReference type="STRING" id="75743.A0A401PWM9"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM AAA-lid" evidence="1">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="108" mass="12218" checksum="F489E4B6AE3812E0" modified="2019-05-08" version="1">MWIPETLADYITAAYVEMRKESRVNKDMTFTSARTLLSVLRISTALTEVKLRPEGHKFVCNTCSESLVMELVIISICLDMELCDHFNMMLTGGSTVRILDVLSNEVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZE9</accession>
    <name>A0A401PZE9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome receptor lysine/proline rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009182">
        <property type="protein sequence ID" value="GCB78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZE9"/>
    <dbReference type="STRING" id="75743.A0A401PZE9"/>
    <dbReference type="OMA" id="ANQDEAK"/>
    <dbReference type="OrthoDB" id="6410656at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007794">
        <property type="entry name" value="Rib_rcpt_KP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040248">
        <property type="entry name" value="RRBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939">
        <property type="entry name" value="RIBOSOME BINDING PROTEIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939:SF4">
        <property type="entry name" value="RIBOSOME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05104">
        <property type="entry name" value="Rib_recp_KP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome receptor lysine/proline rich" evidence="8">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB78524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="244" mass="26518" checksum="F2D7E6BA2ECA13F1" modified="2019-05-08" version="1">MDIYDPQTLGFMVFGGFMVISAIGIFLVSTFSMKETSYEEALAKQKKEQEKAQQVKSEKKKKEKSVEKKGKPKKRDEKPNGRIPESEPVQDASEAEVEVEPAVVPTIEPPIMAVSPPLPPPPESSPPASKERRKKEKKVAKVEPAPSPVSPHAPVSTSSKQTMAPMVETVMREVPVMAVPPVGVQQAAPVATTPSTVAAKKIDVTANQDEPKQDAPAKKKIAPKKKSEPSKYSRILEMSLFPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q065</accession>
    <name>A0A401Q065_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009231">
        <property type="protein sequence ID" value="GCB78787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q065"/>
    <dbReference type="STRING" id="75743.A0A401Q065"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="43" mass="4905" checksum="8A521580F65B9443" modified="2019-05-08" version="1" fragment="single">ARIYVEGKLDYGEYVDKSNVRRQATTIVADNIIFLSDSVKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0M7</accession>
    <name>A0A401Q0M7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyadenylate-binding protein-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0021250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAIP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018493">
        <property type="protein sequence ID" value="GCB78941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0M7"/>
    <dbReference type="STRING" id="75743.A0A401Q0M7"/>
    <dbReference type="OMA" id="MWIENEE"/>
    <dbReference type="OrthoDB" id="5985142at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040396">
        <property type="entry name" value="PAIP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13154">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13154:SF2">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB78941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="78" mass="9108" checksum="DA82BE7875C8E975" modified="2019-05-08" version="1" fragment="single">IVEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTIGQIQEQLNGLVINGNGSVEDLVSKSNLNPNAKEFVPGMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q212</accession>
    <name>A0A401Q212_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multidrug and toxin extrusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0016951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010643">
        <property type="protein sequence ID" value="GCB79390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q212"/>
    <dbReference type="STRING" id="75743.A0A401Q212"/>
    <dbReference type="OMA" id="MAMFVCE"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB79390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="475" mass="51328" checksum="CF6A3FDF314A9A36" modified="2019-05-08" version="1">MTDLMQVASSTAPQTPGTCGNLFLRKIRRILPGNFWQEAKDLTRLAGPVFLAQLMILLLNVVSTIFCGHLGKVELDAVSLATAMVNVSGISVGAGLSIACDTLISQTFGSKNLKRIGVILQRGILILMIACFPCWAIFINTENILLAFKQSPEVAKLTSTYVMIFVPALPAVFLYQLEMRYLQNQGITMPQILTGFIANIFNALVNYLLLNVLALGVQGSAAANVVSQYCQTSLLFGYIRWRKLHVKTWEGIISEVQLGAQCVLYQILSIVYMAPLGFSVAAAVRVGTALGAGNPEKAKNSAKVALWCIVLRGAGMQRLGAIGNLVGFYLIGFPIGISLMFAAKLGIIGFWYGIIICVFCQFTFYQIVICRMNWNEASNQALINAGVKKDVGPSHSTSGGQTENISTGAHPGNIAVIEVGPVENNVGPEHLRRESFAPKTSVCEILTVKQLIIRRGLAFLSGPLILAIGLLLKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q253</accession>
    <name>A0A401Q253_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0021294</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018606">
        <property type="protein sequence ID" value="GCB79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q253"/>
    <dbReference type="STRING" id="75743.A0A401Q253"/>
    <dbReference type="OMA" id="FTRHSTD"/>
    <dbReference type="OrthoDB" id="7327383at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000289">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF25">
        <property type="entry name" value="ZGC:110075 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB79424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49110" checksum="C4C538CC55900190" modified="2019-05-08" version="1" fragment="single">MYYSSAYYRIGQKGKFERDNFVNKQMKMGSKSESYVKEFTRHSTDMMLNLNEMRKREILTDVKVFVDGEEFKAHKAVLIACSVPHVHTYLKSLDYPLSRSLACSLGMESGALSFLPSRTLAPHRAPRLLTGSAAGGCGYFPESAFRFPDGCVAPRKAAGGTRREGPAVGGGHWGEAKASWRGGPGTCAGSRPEPCPEARGPKGRRLPEEKASAERPTPCNEKSSKVPVQAPDSPMRSDCRPNSPTESQSAVLDCSPSARKPADPGPNPKACNWKKYKFIVLNSLRQAVKEQADAGSCSPTTLSSSPEPRGGSSSSDESSSTNMEEETEDEDSARNKAASRSSPDSQDSSGYCVCSICELDFKHGSELRRHILVSHPGEEIPEYHLEFSDSGSDYGLFSCSTCELKLSDEESLQRHFLCVHSDDKPYKCDMCQAAFRYKGNLASHKTVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q337</accession>
    <name>A0A401Q337_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014738">
        <property type="protein sequence ID" value="GCB79733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q337"/>
    <dbReference type="STRING" id="75743.A0A401Q337"/>
    <dbReference type="OMA" id="DMRRIFR"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="146" mass="17091" checksum="45D3347CA002732B" modified="2019-05-08" version="1" fragment="single">PGDVIYPRDENGKYLYHLTDLCATWEVECHPYFTQLKLREFCDSHGIVIVGFSPLGTCRDSLWVNTKIPPLLDDALLNSVAAKYKKTSAQVALRFQLQRNTVIIPKSFNPERIKQNFENFVILDMRRIFRFPSRCLYPGRHYSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4W6</accession>
    <name>A0A401Q4W6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0017164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010936">
        <property type="protein sequence ID" value="GCB80402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4W6"/>
    <dbReference type="STRING" id="75743.A0A401Q4W6"/>
    <dbReference type="OMA" id="NKAPGAM"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB80402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="272" mass="31207" checksum="79D80F30EB9AB41B" modified="2019-05-08" version="1">MEGNRDEAEKCLQIARRALQEGQPDKALKFLHKAEKLYPSVEAKALIDAITTNGSAAGAGRRSESGKPYQRKSASSGTENGTTTEKETKVDSAKVYTKEQLEGVQRIKRCKDYYEILGTNKDASEEDLKKAYRKLALKFHPDKNHAPGATEAFKVSVLSQLMVTTPPYSLYYRAAMEHTVRKQTSNLKVVYYVNKDFDKEYTGVTVQKVEKSVEEDYINNLRNNCWRERQEKNDYLYASKVYRDDRLRKKAELMRMESCEKLARLNDLYRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q535</accession>
    <name>A0A401Q535_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0016221</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01009669">
        <property type="protein sequence ID" value="GCB80481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q535"/>
    <dbReference type="STRING" id="75743.A0A401Q535"/>
    <dbReference type="OMA" id="CEKKYDI"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059042">
        <property type="entry name" value="Znf_C2H2_ZNF598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23208">
        <property type="entry name" value="zf_C2H2_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="306"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="492"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="563"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB80481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="873" mass="98116" checksum="4F13E560AD507BCE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q634</accession>
    <name>A0A401Q634_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024996">
        <property type="protein sequence ID" value="GCB80833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q634"/>
    <dbReference type="STRING" id="75743.A0A401Q634"/>
    <dbReference type="OMA" id="PAMMPAD"/>
    <dbReference type="OrthoDB" id="10425052at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="414" mass="42137" checksum="05ACB13CDCD74813" modified="2019-05-08" version="1">MAQIPPHPSLGDQIPAGRYPGLPTDQSAGAPADQPQDVTAARSVGKPAEQLLITTPADQSQPLPAAEPPAAMPTDRNRPLPAAEPPAVMPADRNRPLPAAEPPAVMPADRNRPVPTAESPAVMPADQPRPVPTAEPPAVMPADRPRPVPAAEPLTTMPADQPRPVPAAEPPAAMPADQSQPVLAGEPPAAMPADQSRPVLAGEPPAMMPADRSRPVLAGEPPAAMPADQSRLVLAGEPPAMMPADRSRPVLAAKSLAAMPADRSLPVLAAKPPAAMPADQPVGHVHPASGAGPPPLTTNPSPATPSAYARPPASPTGLADRPRHPSAEHPRPAALPASPHGSCGPPPADAVSVADTVSLYGHVDSVSMYGTAESLLQDDGSSLGSDSELNGSTTSSQRTDKYGFLGGTQFCGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8S2</accession>
    <name>A0A401Q8S2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020395">
        <property type="protein sequence ID" value="GCB81770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8S2"/>
    <dbReference type="STRING" id="75743.A0A401Q8S2"/>
    <dbReference type="OMA" id="FNENSHD"/>
    <dbReference type="OrthoDB" id="10063284at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="468" mass="54099" checksum="DE06CDE428A4F6D8" modified="2019-05-08" version="1" fragment="single">MGAIELIAEFDPFLHEHLEKCNNEKVNATYLSKPVYEELIEIMGKHVQDEIVNQINNLDMKYYSIIVDSTPDLTHVDQLVIVVRYCYNGKPCERFLTFLPIENHSFPNLFNKIQVLSEHKLSLENIRGQSYDNTSNMKGSEKGLQALFKNINRYADYVPCAAHSLNLVGEKAVSTVPEVVDYFGILQELDVLFSGSPRRWGILNTQGNLHFSLKSLSVTRWSSHYEAVRAIKNGYMGILQTLKHIFEDSEEKLECKQDAKNLYHKLVKLEYAILTVVWEEVLERFNKTKLRENSADRIAHYESEAKGLCEDITSSYSDASKRIVTRTFSDGTSGVASLRGADKFRIEVLYQLYDSLIIQLSKRIDPYEQIAKRFKFLSELVNNSEIDEDSIKLIISYYKDDIDHKLVNKCYQFKEYLHRRKSQDTEVNTSSKMQCAEVLQLICEQHLIEVFPNITTAFKLYLTMPIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Y2</accession>
    <name>A0A401Q8Y2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="9">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0021470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="9"/>
    <dbReference type="EMBL" id="BFAA01019126">
        <property type="protein sequence ID" value="GCB81834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8Y2"/>
    <dbReference type="STRING" id="75743.A0A401Q8Y2"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB81834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="237" mass="26567" checksum="2C5BB75E2FAC2BDB" modified="2019-05-08" version="1" fragment="single">LYILDRRFKGLDECCNQLTAFLYSFSQQSRRQRIIQRNRTERLSDLLDWRYLGRYYTHARFLALAKAFPSNFSQDLAQMSVSFHYSRPASTPPSPSFSGSSTPHYSDSETERYNEEEEALKDRKNIKIDSMLDLLHQQNKNVKDTFEAFRNSSINNLRTSARLSIPSSATTATSPSKSTNPSDANKPTNPIPSNTPSIPAYPTEVNKPTNPIPSNAPSNPANPDAANKPTNPSDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9T0</accession>
    <name>A0A401Q9T0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023216">
        <property type="protein sequence ID" value="GCB82077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9T0"/>
    <dbReference type="STRING" id="75743.A0A401Q9T0"/>
    <dbReference type="OrthoDB" id="20799at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF54">
        <property type="entry name" value="[F-ACTIN]-MONOOXYGENASE MICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="141" mass="15640" checksum="F6F5AB5D9856C1EC" modified="2019-05-08" version="1" fragment="single">CLVIGAGPCGLRTAIELGFLGAKAIIVEKRDTFSRNNVLHLWPYTIQDLRNLGAKKIYGKFCAGAIDHISIRQLQLVLLKIALILGIEIHLNVEFRGLLPPRGQKNPSPGWRAEINPPNSKMTQFEFDVVIGADGRRNTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9Y2</accession>
    <name>A0A401Q9Y2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0022294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021982">
        <property type="protein sequence ID" value="GCB82194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9Y2"/>
    <dbReference type="STRING" id="75743.A0A401Q9Y2"/>
    <dbReference type="OMA" id="WETHCCK"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="305" mass="35002" checksum="DC3E8A9E714CF2CB" modified="2019-05-08" version="1">MRLLSDDSSSFAGELRQLEEEHEKLFHKWMLQTQLGFSLILYGLGSKRELLEEFRSRMLEGTIHVVVNGFFPSITLKSILNSVTEEVLGYEGSFRNPVDQLNFIIRAFEEDSTLDLYLLIHNIDGQMLRGGRNQQILSQLSTIPGIHLIASIDHLNAPLMWDQTRSCLFNWLWYEVTTFKPYTEETSYENSLLVRQSGALALSSLTHVLRSLTPNARGIFKLLAQFQLENKDNPSYPGLSFQDFYQRCRDAFLVNSNLTLRAQLTEFRDHKLIRNKKGADGVEYLIIPVDAATLSDFLETEDRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QAW8</accession>
    <name>A0A401QAW8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024804">
        <property type="protein sequence ID" value="GCB82496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QAW8"/>
    <dbReference type="OMA" id="CSCELGT"/>
    <dbReference type="OrthoDB" id="10031141at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046642">
        <property type="term" value="P:negative regulation of alpha-beta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002720">
        <property type="term" value="P:positive regulation of cytokine production involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000406">
        <property type="term" value="P:positive regulation of T cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46838">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46838:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="2">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="94" mass="10580" checksum="350457F390FD303E" modified="2019-05-08" version="1" fragment="single">SYVMRDCSPTAETLCVSCRQGEYMDVWNGLMNCLRCSDCDPDYGFKEWQSCTASQPRLCNCADGFYCEKRTDDGGCKSCKRRLICQTGEGTIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB15</accession>
    <name>A0A401QB15_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0021644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01019553">
        <property type="protein sequence ID" value="GCB82560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB15"/>
    <dbReference type="OMA" id="HYGKRET"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="160" mass="16515" checksum="4D5B6830A94A592A" modified="2019-05-08" version="1">MESTAAERAAAERAAVESAAAERAAAERAAVERAAMERAAMESTAAERAATERAAAERAAAESTAAERAAAESTAAEPAAAERAAAKRAAAKRAAAKRAAAEWAAAEPAAAERAAKESAAVEREATAEDGEPAAQQAEEEVPKRCRMSPRGYRCRLSFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC43</accession>
    <name>A0A401QC43_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01028755">
        <property type="protein sequence ID" value="GCB82912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC43"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8356" checksum="E63C3527A07D286A" modified="2019-05-08" version="1" fragment="single">IQPFFIDCYNDCTRFRKSIPRIVGATEELPTKLQTPPTPGYATKRTAFYAAVAVLTFVIIFGCIVWAQLKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCM5</accession>
    <name>A0A401QCM5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0023719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01032897">
        <property type="protein sequence ID" value="GCB83067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCM5"/>
    <dbReference type="STRING" id="75743.A0A401QCM5"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB83067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="66" mass="7107" checksum="59014C4133ACE6E4" modified="2019-05-08" version="1" fragment="single">GVEKPFTEVIKANIGDAHAMGQKPITFIRQVLAICTFPNLLCDHTVPEDAKTRAQKLLDGCGGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFQ5</accession>
    <name>A0A401QFQ5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01066526">
        <property type="protein sequence ID" value="GCB84258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFQ5"/>
    <dbReference type="STRING" id="75743.A0A401QFQ5"/>
    <dbReference type="OrthoDB" id="2324346at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010855">
        <property type="term" value="F:adenylate cyclase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026919">
        <property type="entry name" value="ADGRV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682:SF1">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12638" checksum="C5E4781C2E30E561" modified="2019-05-08" version="1" fragment="single">LDEHYSVILSSHSIPPSKLGAATQINITVLKNDDPHGVIQFITQECTKTINESKGDTLYTATFPVIRDRGTFGDVSVFWIVDPIFTNDVYPVQGVVNFNNAESSKNITLQSLPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QG67</accession>
    <name>A0A401QG67_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01073813">
        <property type="protein sequence ID" value="GCB84418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QG67"/>
    <dbReference type="STRING" id="75743.A0A401QG67"/>
    <dbReference type="OMA" id="GHEEPFF"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF12">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11608" checksum="C5B9DC1C943688D5" modified="2019-05-08" version="1" fragment="single">SKEIESSGFNGTAAFMEVRVQSIVVEFILNHVEQLFGSKNLQLNPGLLPDDRRKSLPSPSSAPNLAYDEAGCRFLASQIPHTLHMGDGPPAMRPYHSIIELPEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH76</accession>
    <name>A0A401QH76_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01091842">
        <property type="protein sequence ID" value="GCB84788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH76"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="54" mass="6589" checksum="9F9CF0745B861768" modified="2019-05-08" version="1" fragment="single">MQKKREGARFDENEKRESFKGKWRKSHWKKEKERDFQLCTQAAVTEKSEQTAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI28</accession>
    <name>A0A401QI28_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0025603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01110662">
        <property type="protein sequence ID" value="GCB85002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI28"/>
    <dbReference type="STRING" id="75743.A0A401QI28"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028745">
        <property type="entry name" value="AKAP9/Pericentrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="7735" checksum="4EB7E11277281D8F" modified="2019-05-08" version="1">MTGAVSPHFTESIFNGGLVDPEAEELVLNVGTRHQAALENLLEAITETTDLLDVRTTQTELKRESVRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIJ2</accession>
    <name>A0A401QIJ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0025861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01134146">
        <property type="protein sequence ID" value="GCB85177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIJ2"/>
    <dbReference type="STRING" id="75743.A0A401QIJ2"/>
    <dbReference type="OMA" id="WREACRG"/>
    <dbReference type="OrthoDB" id="10060000at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF24">
        <property type="entry name" value="FIBROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB85177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="292" mass="32281" checksum="AFDB4B178F965BEE" modified="2019-05-08" version="1">MGREPSPYSRLPATSEGPKPSLLRELAKRHEVKVKEERKEEHDLMAGGVAPPGFESTAQLQRAHVPGGAAHTLHALHSLPVPLAVIGQVNGLGVLERNRVLAGPFLGVGHHGMASSAGGERLPHYGWDPFRDSWREACRGPEVPSIHQRYPVPQHQPQPRFYEPERAYRERQLLREFVPEGLLAETRREQEAAGLLEEQLLLREEYDHRARLLSFLGSPHPPHHPYPRVSPSLVHQSGLLSKTPPMATLGAPPPLISSTGVRPGSPATRATPLSANELRDLSAYSHKDRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIP5</accession>
    <name>A0A401QIP5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0025992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01147486">
        <property type="protein sequence ID" value="GCB85238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIP5"/>
    <dbReference type="STRING" id="75743.A0A401QIP5"/>
    <dbReference type="OMA" id="TTQDSAC"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN RHES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20228" checksum="735FB9640F311193" modified="2019-05-08" version="1" fragment="single">GDVFILVFSLDSRGSFEEVQRLRRQIIECKMCLKDKTKEAMEVPIALCGNKADRVELHREVQAEEAERLIADDANSAYFEISAKKNSNVEEMFRALFSMAKLPHEMSPALHRRISVQYSEALHRKSFRLRRVKEVGAFGMVSPLARRPSVNSDLMYIKEKVLGQGQAREREKCLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKI4</accession>
    <name>A0A401QKI4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0026585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01217028">
        <property type="protein sequence ID" value="GCB85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKI4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="287" mass="29180" checksum="A890AE44000B8704" modified="2019-05-08" version="1" fragment="single">DDVDVGDDIDVGDEVEVGDDIDVGDIVDVAEDADVGDDVDVCDDVDLGDDVDLGDDVDVGDNVDMGDDVDVGDDFDVGDDVDMTNAVDMDDAFDVGDAVDLGNDVDVADDVDVADDIDVANDVDESGDVDVGDNVDAGDDVDDDDAVDVSDDVDVCDNVDVVDAVDVGDVVNVGVDVDMGDVDIGNALYVCHAVDMGDAVDVGDDVDVGDAVDVGDDIDVGDVVDVAEDADVGDDVDVCDGYDVGDAVDLGDAVDLGDDVDLGNDVDLGDDVDVGDDVDVGDDVDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL27</accession>
    <name>A0A401QL27_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01239057">
        <property type="protein sequence ID" value="GCB86121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL27"/>
    <dbReference type="STRING" id="75743.A0A401QL27"/>
    <dbReference type="OMA" id="KQRETHT"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="159" mass="20001" checksum="3EC189010084F6D3" modified="2019-05-08" version="1">MMDGIPANSTDPCTVQYLAAPLCLLYNNAKNKLVPIAIQVGGLCVRERERERDTEGERERQRQREREERQRERERETQREKEREKQRQREREERQRERQRDRERDRQTERERDRQTDRQREIEKEKDRERGRQRDTEGERERDRDRERETERETHREKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLE2</accession>
    <name>A0A401QLE2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01254096">
        <property type="protein sequence ID" value="GCB86195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLE2"/>
    <dbReference type="STRING" id="75743.A0A401QLE2"/>
    <dbReference type="OMA" id="DTWSRTD"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="70" mass="8496" checksum="CC1AD804D82E42CE" modified="2019-05-08" version="1" fragment="single">MDTRSRTDTRSRTDTWSRTDTRSRTDTRSRTDTWSRTDTRSRTDTRSRTDTRSRTDTRSRMDTRSRTDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QMS5</accession>
    <name>A0A401QMS5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01328834">
        <property type="protein sequence ID" value="GCB86690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QMS5"/>
    <dbReference type="OMA" id="AVNIGVQ"/>
    <dbReference type="OrthoDB" id="10619270at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="220" mass="20055" checksum="73A90BCDF87C3B49" modified="2019-05-08" version="1" fragment="single">AVDIGVQVGGAPRAVDIGVQVGVAPRAVDIGGSVGGAPRAVDIGGSVGGAPRAVNIGVQEGGAPRAVDIGVQVGGAPRAVDIDGSVDGAPRAVNIGVQVGGVPRAVDIGVQVGGAPRAVDIGGSVGGAPRAVNIGGSMGGAPRGVDIGGSVGGAPRAVDIGGSMGGAPRAVDIGGSVGGAPRAVDIGASVGGAPRAVDIGGAVGGAPRAVDIGGSVGRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNV3</accession>
    <name>A0A401QNV3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01404611">
        <property type="protein sequence ID" value="GCB87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNV3"/>
    <dbReference type="OMA" id="WNEEPNG"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="188" mass="16286" checksum="B13CED6AA162C731" modified="2019-05-08" version="1" fragment="single">DNGGGAGDVDNGGSDGDADNGGGDVDNRGGDGDADNGGGDGDADNGGSDGDADNGGGDADNGGGDGDADNGCGYGDADNGSGDAETGGGDGDNGGGDGDADNGGGDGDADNGGGDVDGDNGGGDGNADNGGDDGDADNGGGVADNGGGDGGADNGGGDGDADNGGGDADIGGSDGDADNGGDDGDADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJW3</accession>
    <name>A0A401NJW3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0006994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002458">
        <property type="protein sequence ID" value="GCB61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJW3"/>
    <dbReference type="STRING" id="75743.A0A401NJW3"/>
    <dbReference type="OMA" id="ERIQMTA"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="169" mass="19647" checksum="B60E879BC9B9CDD1" modified="2019-05-08" version="1">MSLINKNILWLTRTLRRRSLCAQETSPVQESRYNKLSRAVRELARKIRDLDEKDSFRTKSTSRLLEKLYAAGLIPTKQGLQLCDKVSASSFCRRRLPTIMLKLRMAQNLKTAITFIEQGHVRVGPEVVTDPAFLVTRNTEDYVTWVDSSKIKQHVMEYNEERDDFDLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJX9</accession>
    <name>A0A401NJX9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005064">
        <property type="protein sequence ID" value="GCB61211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJX9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="208" mass="24100" checksum="6DD541ED5D411CCF" modified="2019-05-08" version="1">MISGSRETERRVEDLKTIDWNVPTIGQKLEPLDWNDATIDEDLEPLDWNDIMYEDLDPPDWNDIMYEDLDPPDWNDIMYEDLDPPDWNDTMYEDLDPPDWNDTAENQETGLIYYDSLILYHGFFGVISFISKDGVPLEQKIRFALRFLQGLLYPMLAVVGVPSKCPFPVINSVKPGYLYYCSCHLLSTAAAFVSVECRYSVINLPPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKZ6</accession>
    <name>A0A401NKZ6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DHX30</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAH box protein 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0004115</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01001189">
        <property type="protein sequence ID" value="GCB61548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKZ6"/>
    <dbReference type="STRING" id="75743.A0A401NKZ6"/>
    <dbReference type="OMA" id="GCILFCT"/>
    <dbReference type="OrthoDB" id="3363059at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17976">
        <property type="entry name" value="DEXHc_DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000017">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000414">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000375">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF257">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="477"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="684"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB61548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1215" mass="136241" checksum="7D744AF8BCBDEBE9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NL13</accession>
    <name>A0A401NL13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">T-complex protein 11-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0012941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006414">
        <property type="protein sequence ID" value="GCB61573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NL13"/>
    <dbReference type="STRING" id="75743.A0A401NL13"/>
    <dbReference type="OMA" id="DPPEYHH"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF17">
        <property type="entry name" value="T-COMPLEX PROTEIN 11-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB61573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53373" checksum="892B8BC5A7476FFD" modified="2019-05-08" version="1">MEGEKGHARLSESARQFIHLSDLQSCYKATKFESEKMPFSNEKHSLNDESLNSDTESCQRSDSVNSSSDYEYARQSFSSDSSSKPSSPASSPPKMASFDDLMETAKGLSNMTLAHEIVMNSNFQMKQIDLPPQSLQRKVKEIVHKAFWDCLEAQMNQDPPEYHHAIVLLGEIKEILLSFLIPGQNRLRNQISEVLDLDLIQQQAEHNAIDIHKLAAYIISLMGKFCAPVRDDDVKKLKSVTEIVPLFREIFHVLDLMTMDMINFTIQNIRPHIQQCSVDYERSKFQDFLNKQPNALDYTTQWLKESITEVSTSVPSSDTSPSDADRSSSLSLSPSSVLNNGYLKFLQWDYDNKPVPETLMTDRSRLQELQQKLNLQRLVAYIMLIIYNMVGATISGLPEFADKLKRVIVVLLEGMQGKLLTVKLVLGLLLTNMSSLFFEIKLVFFAFNNSRFGNNNLQILGLSTHQLNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NL63</accession>
    <name>A0A401NL63_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LBH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0011344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005115">
        <property type="protein sequence ID" value="GCB61616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NL63"/>
    <dbReference type="OrthoDB" id="9949623at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038990">
        <property type="entry name" value="LBH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042945">
        <property type="entry name" value="LBH_dom_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14987">
        <property type="entry name" value="PROTEIN LBH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15317">
        <property type="entry name" value="Lbh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LBH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB61616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="153" mass="16965" checksum="56822465D5D25EC4" modified="2019-05-08" version="1">MRETERQNPPLQRTWTETFHLLGESVMEKVSLKEDVEHLPVQIFPDPLESVDECCRRIKGRLPSIVVELTDTGEVESGELRWPPEDFSPCEDVDNSFEVGAEPDDPSESNPEPGGSTPQGDEETQEGTAEAESDDGSRPATLPRDCQGASRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLD0</accession>
    <name>A0A401NLD0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein</fullName>
            <shortName evidence="15">Cnt-b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Centaurin-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0004138</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endosome membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001198">
        <property type="protein sequence ID" value="GCB61685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLD0"/>
    <dbReference type="STRING" id="75743.A0A401NLD0"/>
    <dbReference type="OMA" id="RTIPYKN"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08835">
        <property type="entry name" value="ArfGap_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13250">
        <property type="entry name" value="PH_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000007">
        <property type="entry name" value="Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000025">
        <property type="entry name" value="arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000020">
        <property type="entry name" value="Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000026">
        <property type="entry name" value="Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF241">
        <property type="entry name" value="ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0967">Endosome</keyword>
    <keyword evidence="3 15" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="255"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="19">
        <location>
            <begin position="390"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="673"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="516"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB61685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="777" mass="87209" checksum="4C65DB264DEA2CBC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM46</accession>
    <name>A0A401NM46_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005158">
        <property type="protein sequence ID" value="GCB61919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM46"/>
    <dbReference type="STRING" id="75743.A0A401NM46"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="76" mass="8734" checksum="893523A9855BE106" modified="2019-05-08" version="1">MSRSPLNNILNTEESVHQINTFLQSVQMLLEAASHIERIETENERRYTLTMTPARINVNAIVHHCRDGAMGERLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM89</accession>
    <name>A0A401NM89_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001218">
        <property type="protein sequence ID" value="GCB61969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM89"/>
    <dbReference type="STRING" id="75743.A0A401NM89"/>
    <dbReference type="OMA" id="THAEAYY"/>
    <dbReference type="OrthoDB" id="542946at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="678" mass="77127" checksum="6974D2A9728B8F50" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNV3</accession>
    <name>A0A401NNV3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein of 135 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0013083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006548">
        <property type="protein sequence ID" value="GCB62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNV3"/>
    <dbReference type="STRING" id="75743.A0A401NNV3"/>
    <dbReference type="OMA" id="QGRENTM"/>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22292">
        <property type="entry name" value="cc_Cep135_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN 135KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="503"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="885"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB62588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="118656" checksum="ECF366010D3ABB19" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NP76</accession>
    <name>A0A401NP76_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin-like protein KIF6/9 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0004293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001263">
        <property type="protein sequence ID" value="GCB62708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NP76"/>
    <dbReference type="STRING" id="75743.A0A401NP76"/>
    <dbReference type="OMA" id="CEAFETF"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-like protein KIF6/9 C-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="243" mass="27610" checksum="47F2388C9EC51BB9" modified="2019-05-08" version="1">MSLGRQEAFEIFRRDYADSVTIEDNKQLLKQRFIEAKSLGEKVNQSRNKINQLKGQLEQRRMQRAACSVTSEPVDVTEPDHLEDDLREKIEEEKKSYKMTFNRLKVLKTEIEHLQHLLEKAKMMVQKDFEVWWSEEAVRLQVEQEQLSEAICQTPYKTPSVTPAASQRSLHSSSSVETSSGYMSTDSAARNSVRICKLSSPELSLPSSIGSSIPLTGDGQTDSDILAFVRARQSLMQRKGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPN0</accession>
    <name>A0A401NPN0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0007291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002613">
        <property type="protein sequence ID" value="GCB62845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPN0"/>
    <dbReference type="STRING" id="75743.A0A401NPN0"/>
    <dbReference type="OMA" id="RAQEWKS"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18449">
        <property type="entry name" value="BACK_KLHL9_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18239">
        <property type="entry name" value="BTB_POZ_KLHL9_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000002">
        <property type="entry name" value="Kelch-like family member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000001">
        <property type="entry name" value="Kelch-like family member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000011">
        <property type="entry name" value="Kelch-like family member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF11">
        <property type="entry name" value="KELCH-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB62845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="640" mass="72043" checksum="FA4DB51B2DA95FF8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPS5</accession>
    <name>A0A401NPS5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">scyTo_0007303</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002619">
        <property type="protein sequence ID" value="GCB62901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NPS5"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SMC"/>
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        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="21">
        <location>
            <begin position="615"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="327"/>
            <end position="351"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1145"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="484"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="760"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1047"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1149"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GCB62901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1295" mass="150454" checksum="871991DF7D3B0DBA" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQU0</accession>
    <name>A0A401NQU0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0011587</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01005320">
        <property type="protein sequence ID" value="GCB63240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQU0"/>
    <dbReference type="STRING" id="75743.A0A401NQU0"/>
    <dbReference type="OMA" id="XAKVMAN"/>
    <dbReference type="OrthoDB" id="10016527at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000030">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF8">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="909"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="465"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="976"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB63240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1002" mass="115997" checksum="A2A24CFB2BA6B46D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSM1</accession>
    <name>A0A401NSM1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nitric oxide synthase-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E3 ubiquitin-protein ligase NOSIP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase NOSIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0011679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOSIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005400">
        <property type="protein sequence ID" value="GCB63898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSM1"/>
    <dbReference type="STRING" id="75743.A0A401NSM1"/>
    <dbReference type="OMA" id="CHKGHIF"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16661">
        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001144">
        <property type="entry name" value="Nitric oxide synthase-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="8">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB63898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="256" mass="27643" checksum="40A9693D497DF03E" modified="2019-05-08" version="1" fragment="single">CACSGPPPSDLLPPAAPEGSSPPFPFRSGQTDALPAWRACCLGESEARIKGLRHAAGVRAMTRHGKNCTAGAVYTYYEKKKDTAVSGYGTQSLRLSKDAIKDFDCCCLSLQPCKDPVITPDGFIYEKEAILEYILHQKTEIAKKIKAYEKQKNIKKTELAELAKAEKESKVKAFLEKESTIVSKPLNPFSSKEGEAQASSSTEPVQHGGEKHLPSFWIPSLTPEAKASTVRKPGGTGFAGSGVKLEAKESRPVMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVM8</accession>
    <name>A0A401NVM8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit E-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EIF3L</name>
        <name evidence="4" type="synonym">EIF3EIP</name>
        <name evidence="4" type="synonym">EIF3S6IP</name>
        <name evidence="6" type="ORF">scyTo_0007610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002795">
        <property type="protein sequence ID" value="GCB64919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVM8"/>
    <dbReference type="STRING" id="75743.A0A401NVM8"/>
    <dbReference type="OMA" id="INRVTAC"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20272">
        <property type="entry name" value="Complex1_LYR_MIEF1-MP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045300">
        <property type="entry name" value="Complex1_LYR_MIEF1-MP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="327"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB64919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="656" mass="78247" checksum="188C53DFA3EEE7AD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVR3</accession>
    <name>A0A401NVR3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thyroxine-binding globulin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Serpin A7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">T4-binding globulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0009896</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Major thyroid hormone transport protein in serum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004152">
        <property type="protein sequence ID" value="GCB64934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVR3"/>
    <dbReference type="STRING" id="75743.A0A401NVR3"/>
    <dbReference type="OMA" id="GHSSQWE"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19957">
        <property type="entry name" value="serpinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000003">
        <property type="entry name" value="alpha-1-antitrypsin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000001">
        <property type="entry name" value="Serine protease inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.310.10:FF:000001">
        <property type="entry name" value="Serpin family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.310.10">
        <property type="entry name" value="Serpins superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF375">
        <property type="entry name" value="THYROXINE-BINDING GLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00780">
        <property type="entry name" value="LEUSERPINII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019280703" description="Thyroxine-binding globulin" evidence="11">
        <location>
            <begin position="19"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="12">
        <location>
            <begin position="64"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB64934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="425" mass="47236" checksum="48FE6244F4DD5719" modified="2019-05-08" version="1">MGKLIPVALLLIAVLCSGIVCVSEKVSVLKTSSQQARAGSRTKNNLHRQLSLLKLSAANTDFALRLYRQIASQPSSTARNIFFSPLSISASLAMLSLGAKHDTRDQLLQVLGYYNMSRNDAAEVHSAFKYLLQEITSEKREPQLAMGSSLHIQQGLSLQKKFLEDAKQFYKAETVSADFRAADKAKKMINTYVKKQTRGKIQELIKSLNRNTVMILLNYVLFKGKWVKPFDPQDTYEDDFHVDNTTTVKVQMMKRKGRYSMNYDTGLASSVILIPYKGNASLVLILPDRGKLAGVEQNLTITNFQNLITSLRIGSVDLHLPKFSLKSSYQLKHLLMTMGIVDAFTNKANLSKITKSAPLQVSKVVHEAVLDVDEKGTEAAAVTGISLMPMSRPSQLKLNRPFLLLIAEHNTKSVLFAGRVMNPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW46</accession>
    <name>A0A401NW46_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0009916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004166">
        <property type="protein sequence ID" value="GCB65082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW46"/>
    <dbReference type="STRING" id="75743.A0A401NW46"/>
    <dbReference type="OMA" id="DINSECN"/>
    <dbReference type="OrthoDB" id="10071893at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF402">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="100"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="359"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB65082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58580" checksum="78688936D3CD13A9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYS9</accession>
    <name>A0A401NYS9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spondin-like TSP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0007820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002900">
        <property type="protein sequence ID" value="GCB66062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYS9"/>
    <dbReference type="STRING" id="75743.A0A401NYS9"/>
    <dbReference type="OrthoDB" id="5814848at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000050">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF30">
        <property type="entry name" value="SPONDIN-LIKE TSP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spondin-like TSP1" evidence="4">
        <location>
            <begin position="72"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB66062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="134" mass="15222" checksum="F4546A6A6527AB83" modified="2019-05-08" version="1">MSPWGPCIEDTLVMPLNATMSWNGEASCSVGMQTRQIHCMKSKVGHVTRKRCPESTRPETVRPCLLPCKKDCVVTPFSEWTPCPTICQQGNSSLAKQSRHRIIIQKPNNRGQECPDTLYEERECEARPLCPNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ83</accession>
    <name>A0A401NZ83_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0014964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008259">
        <property type="protein sequence ID" value="GCB66186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ83"/>
    <dbReference type="STRING" id="75743.A0A401NZ83"/>
    <dbReference type="OMA" id="WIGAIRI"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF528">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00592">
        <property type="entry name" value="CASENSINGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="11">
        <location>
            <begin position="7"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB66186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="308" mass="35302" checksum="6D8E3C22B7AE0D95" modified="2019-05-08" version="1">MQFLLPVLQVSYFSTCACLSNKEEFPTFYRTIPSDYHQSKFLAQIVSKFGWTWIGAIRINNDYGNFGMQAFIETVEKLGVCIAFSESFYRTDPREKILKIVEVIKKSSTKVIVAFSATREMRILLKELLRQNVTDIQWIGSEAWVTSDILAPEDNVKILVGTIGPAIRRSEIPGLRDFLLKVNPFPVPDNVMVKEFWETAFRCSLKSGSVTSQANDWAEMRRCTGKERLEDLQNAYSDLGIDGSTYNVYKAVYALAHAFHNMFACEHGKGPFANKTCVQHPNFQPWQVRRFINSILCLHERKTWAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZB7</accession>
    <name>A0A401NZB7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0004926</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001488">
        <property type="protein sequence ID" value="GCB66211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NZB7"/>
    <dbReference type="OMA" id="IFFAQIK"/>
    <dbReference type="OrthoDB" id="8852462at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022076">
        <property type="entry name" value="Limbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026501">
        <property type="entry name" value="Limbin/EVC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795:SF14">
        <property type="entry name" value="LIMBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795">
        <property type="entry name" value="LIMBIN/ELLIS-VAN CREVELD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12297">
        <property type="entry name" value="EVC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019585246" description="CARD domain-containing protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB66211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1322" mass="150782" checksum="D4FC56AA7835B78F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZE1</accession>
    <name>A0A401NZE1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0004930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001489">
        <property type="protein sequence ID" value="GCB66229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZE1"/>
    <dbReference type="STRING" id="75743.A0A401NZE1"/>
    <dbReference type="OMA" id="NAMHESH"/>
    <dbReference type="OrthoDB" id="10037468at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37915">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37915:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB66229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="299" mass="35314" checksum="2F39B2A2B7200B79" modified="2019-05-08" version="1">MEKSVKEVEFLHRVDEPAWAVLQKTAHVQRCRKVEELKEELETIKRRVSFAMDNYERERKPVQAVFCQANLEFVNDLDELKEALLDSIERKIYQTKVTVFIVGYQEACGERHLILSHLNEFFSKHIGFFMSEEEHLTELDEFEYEEVCERVDEALSSAQQSTQHLAELNQEIINYINIAVLNKDNKKRKRKIEKAPNQTKEEIQKITAKLVSTHSELEEKELKMKELMKLNEVKNLECMHFKSQVEITKKNMERIQQESKLQKVLLDHQSKELEHLRKQLQEAHGKEKLQPQTASVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0S1</accession>
    <name>A0A401P0S1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0015035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008325">
        <property type="protein sequence ID" value="GCB66703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0S1"/>
    <dbReference type="STRING" id="75743.A0A401P0S1"/>
    <dbReference type="OMA" id="CNYATHL"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB66703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="65508" checksum="97744D6E96862970" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1Z4</accession>
    <name>A0A401P1Z4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002992">
        <property type="protein sequence ID" value="GCB67120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1Z4"/>
    <dbReference type="STRING" id="75743.A0A401P1Z4"/>
    <dbReference type="OMA" id="MQSTHRV"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB67120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="207" mass="23267" checksum="7F406FC2153E4556" modified="2019-05-08" version="1">MLSPEGQQLDIKKSSYKKLSKFLQTMQQRQIVQVKELSKGVESITAVSWKHADYVVINPILCDCLLEKSEHHTIAKLTWDDLFTRCLKRLQECHQVTFPGQNPVVRKGGIKPINIDVAQRSSNKKVTIVSNLEAFGLDPQSLVNALQQKAQASVTMHQVPGTKDKMALQVQGNQVNHIAKLLTEEYRIPAKYIAGLDKAPKTGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P259</accession>
    <name>A0A401P259_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="10"/>
    <dbReference type="EMBL" id="BFAA01002998">
        <property type="protein sequence ID" value="GCB67183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P259"/>
    <dbReference type="STRING" id="75743.A0A401P259"/>
    <dbReference type="OMA" id="CFFKLHH"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB67183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="654" mass="73948" checksum="15A97A942D318CF8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2J0</accession>
    <name>A0A401P2J0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 19 member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0013688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007096">
        <property type="protein sequence ID" value="GCB67317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2J0"/>
    <dbReference type="STRING" id="75743.A0A401P2J0"/>
    <dbReference type="OMA" id="PESETMC"/>
    <dbReference type="OrthoDB" id="18814at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000225">
        <property type="entry name" value="Solute carrier family 19 member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF37">
        <property type="entry name" value="THIAMINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB67317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50299" checksum="C884CC6478AC5DB3" modified="2019-05-08" version="1" fragment="single">VTNEIFPVWTYSYLAMLFPVFLVTDYLRYKPIIALQGISFIITWLMLLFAQGVLAMQFLEFVFGIASATEVAYYSYIYSVVSSEHYQKVTSYCRSVTLVAYTLASILGQVLVSVWSVPYFYLNVIALVSVSVAFLSSIPLPMPRTSILFHRKETEKIQVPPSTEDVKPKSENSSPQNNPDGENCSQLPVTSDRNVYTLAKATEQNNAKNVLLKLWSDFIKCYSSPQIFYWSIWWALASCGYYQVTNYIQVLWDHVEPSQNATVYNGGVEAVSTFMSAVTSFAVGYIKLDWAIWGEMALGIFSTVNSGALFAIDLSDNIWICYAGYVVFKATYMLLITIATFQIAANLSMERYALLFGVNTFVALLLQTIMTVIVVDSRGLGLDIITQFLIYGSYFAAISGLFFIRGVYTLIQHRRRRKRKMESEIIKGNNLSPESETMCRNVTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2R8</accession>
    <name>A0A401P2R8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aspartate aminotransferase</fullName>
            <ecNumber evidence="14">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0005120</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70223"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:70225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70295"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="ChEBI" id="CHEBI:140699"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:70297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17441"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="EC" id="2.6.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:17442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01001567">
        <property type="protein sequence ID" value="GCB67386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2R8"/>
    <dbReference type="STRING" id="75743.A0A401P2R8"/>
    <dbReference type="OMA" id="PTWPIHE"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120554">
        <property type="term" value="F:2-aminobutanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047801">
        <property type="term" value="F:L-cysteine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000044">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019530418" description="Aspartate aminotransferase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="16">
        <location>
            <begin position="33"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB67386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="416" mass="46200" checksum="AC45542F7EBB8125" modified="2019-05-08" version="1">MACASSLFAAVPLAAPVAVFKLTADFKEDPHPMKVNLGVGAYRTDASQPWILPVVKKVEQQIVSDTSLNHEYMPILGLPEYTKLACELVLGKDSPAIAENRVGGVQCLGGTGALRIGGDFLRSWYNGTNNTSTPLYVSAPTWANHNGVFGASGFTDIRSYRYWDPAKRGLNLQGLLEDMEKAPEFSIFVLHACAHNPTGTDPSKEEWQKIAEVMKRRSLFPFFDSAYQGFASGDLDRDAWAIRYFVSQGFELFCAQSFSKNFGLYNERVGNLCIVAKDDDNVTKIRSQMEKLARTIWSNPPAHGARIVAMTLGNPQLYTEWKGNVKTMADRVLLMRAQLKEKLEKLGTPGTWDHLTQQIGMFSFTGLDPSQVDYMIKKKHIYLMASGRINMCGLTTSNLDYVAESIYEAVTSRACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P371</accession>
    <name>A0A401P371_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0005147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001576">
        <property type="protein sequence ID" value="GCB67536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P371"/>
    <dbReference type="STRING" id="75743.A0A401P371"/>
    <dbReference type="OMA" id="RTNHLAC"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000036">
        <property type="entry name" value="septin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="39"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB67536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="427" mass="49599" checksum="C268CCA4D0B1A22D" modified="2019-05-08" version="1">MEASETEQLPEAEKRNLNLGGHVGFDSLPDQLVSKSVSQGFSFNILCVGETGIGKSTLMNTLFNTMFESEEATHYEPGVRLKPQSYSLKETNVDLKLTVVNTVGFGDQVNKEQSYKPVVDYIDAQFENYLQEELKIKRSLHDFHDTRIHVCLYFIAPTGHCLKSLDLVTMKKLDSKVNIIPIVAKADTISKSELHKFKIKIMSELVSNGVQIYQFPTDDDAVAEINSTMNAHLPFAVVGSMEEVKVGNKLVKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFMSELHKKEEEMRQMFVMRVKETETDLKEKEKELHDQFDLLKKTHQEEKKKLEEKRRELEEEMNAFNRRRMAAQTLQGQSFQATGQQPVKKDKDRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P699</accession>
    <name>A0A401P699_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">LIM homeobox transcription factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0010433</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004497">
        <property type="protein sequence ID" value="GCB68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P699"/>
    <dbReference type="STRING" id="75743.A0A401P699"/>
    <dbReference type="OMA" id="CYLRERK"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09371">
        <property type="entry name" value="LIM1_Lmx1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09378">
        <property type="entry name" value="LIM2_Lmx1a_Lmx1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000193">
        <property type="entry name" value="LIM homeobox 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000095">
        <property type="entry name" value="LIM homeobox transcription factor 1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF96">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 13" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="17">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45509" checksum="269946651EC516C3" modified="2019-05-08" version="1">MPLATGPQSLDRCFSRREAEAANMLDDIKMEEHPLRSGPATLGMLLGSDCKHKEMCDGCQRPIEDRFLMRVNEASWHEHCLQCAVCQQPLTRSCYFRDRKLYCKHDYDQLFAAKCNGCMEKIAPTEFVMRALECVYHLSCFCCCVCERQLRKGDEYVLKEGQLLCKSDYEKEKELLSSVSPDDSDSVKSDDEDIDIKPNKIQGIQGKACEDAKDQRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLASETGLSVRVVQVWFQNQRAKMKKLARRQQQQQEQQNGQRLGQEVMSNRMDGMINSYAPVGPQQQLVSIDQNGYNSDPFQQGLTPPQMPGDHMNPYGNDSLFHDIDSDTSLTSLSDCFLASSEVNPMQARVGNPIDRLYSMQNSYFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P802</accession>
    <name>A0A401P802_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0008362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003183">
        <property type="protein sequence ID" value="GCB69291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P802"/>
    <dbReference type="STRING" id="75743.A0A401P802"/>
    <dbReference type="OMA" id="CDVSGYQ"/>
    <dbReference type="OrthoDB" id="9890427at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000191">
        <property type="entry name" value="Immunoglobulin superfamily member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000491">
        <property type="entry name" value="Immunoglobulin superfamily, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051102">
        <property type="entry name" value="IgSF_V-set/TM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207:SF21">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207">
        <property type="entry name" value="V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019385326" description="Ig-like domain-containing protein" evidence="10">
        <location>
            <begin position="28"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="972"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="151"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="287"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="411"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="680"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="818"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB69291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1024" mass="116081" checksum="24F850D641BD41C7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8V5</accession>
    <name>A0A401P8V5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0008413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003214">
        <property type="protein sequence ID" value="GCB69597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8V5"/>
    <dbReference type="STRING" id="75743.A0A401P8V5"/>
    <dbReference type="OMA" id="PNHIDAP"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04386">
        <property type="entry name" value="RhoGAP_nadrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="192"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB69597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="860" mass="94030" checksum="73DE43A28DB94ABE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P902</accession>
    <name>A0A401P902_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 15">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0012450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:39159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:74278"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:39160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:45813"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 15"/>
    <dbReference type="EMBL" id="BFAA01006016">
        <property type="protein sequence ID" value="GCB69582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P902"/>
    <dbReference type="STRING" id="75743.A0A401P902"/>
    <dbReference type="OMA" id="PMFPQMY"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF22">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB69582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="240" mass="28228" checksum="D181038227E5391F" modified="2019-05-08" version="1">MAPSEEDGSLEEKENKKKPLSPFATAWLTFYNITMTAGWLVLAVAMIRFSYQKRTHKGLYRSIQKTLKFFQTFALLEIIHCAVGIVRTSVLVTGVQVMSRIFMVWFVIHSIRPIQNEESVVLFLVTWTVTEITRYSFYTFNLLNHLPYFIKWARYNFFIILYPIGVVGELLTIYGALPFVKKSGMYSLRLPNKYNVSFDYYTCLIIVMIAYIPLFPQLYFHMLRQRRKVLHGEVIKEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P918</accession>
    <name>A0A401P918_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin light chain kinase, smooth muscle</fullName>
            <ecNumber evidence="5">2.7.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Telokin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">scyTo_0010597</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.18" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01004605">
        <property type="protein sequence ID" value="GCB69645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P918"/>
    <dbReference type="OMA" id="NCQVSLM"/>
    <dbReference type="OrthoDB" id="2152335at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004687">
        <property type="term" value="F:myosin light chain kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14103">
        <property type="entry name" value="STKc_MLCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000977">
        <property type="entry name" value="Myosin binding protein H like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000175">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000198">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001127">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF1">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="18" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="72"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="170"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="485"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="626"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="722"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="851"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="1198"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="407"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="583"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="801"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="411"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="880"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GCB69645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1302" mass="146103" checksum="8A4C8440A3EB0305" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P920</accession>
    <name>A0A401P920_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0001079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000230">
        <property type="protein sequence ID" value="GCB69580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P920"/>
    <dbReference type="OMA" id="CNWVVIE"/>
    <dbReference type="OrthoDB" id="10071013at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="179" mass="19903" checksum="39158C93B243D23F" modified="2019-05-08" version="1">MPDLAKSKQNSMSPPMTPLSCSSGQASNLSGLPPKMWTLILYISISSLTASSMYNLQNHGIKVLKSLHVSGAEECNQTCDNVADRDGLQCNWVVIEEKRNLCFYLHCLDVQICEGVSVEDVKALQIGQSLPIKIFINRLQKNRTINKRPPRDVANDLPTNRSVKLSKAIKGKTMCKWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9K2</accession>
    <name>A0A401P9K2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Membrane protein FAM174B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0001127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM174 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000240">
        <property type="protein sequence ID" value="GCB69782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9K2"/>
    <dbReference type="STRING" id="75743.A0A401P9K2"/>
    <dbReference type="OMA" id="ASGHCYC"/>
    <dbReference type="OrthoDB" id="9950075at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009565">
        <property type="entry name" value="FAM174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607:SF3">
        <property type="entry name" value="MEMBRANE PROTEIN FAM174B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06679">
        <property type="entry name" value="DUF1180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019556877" description="Membrane protein FAM174B" evidence="10">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB69782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15386" checksum="05F69652E7C79B41" modified="2019-05-08" version="1">MCRWGLCVWPPALLLLLWAPLVLLLAAETSSASEKTPAVSAPLSRNGTAASRSNGTATALDNVASLLRNLSTLKNLVLAACAGAFLLIVCLLVRVIRSGRKIKKTRKYDIITTPAEKVEMTPLNEEDDDDEDATVFDVKYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PA88</accession>
    <name>A0A401PA88_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">POZ-, AT hook-, and zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0010684</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004653">
        <property type="protein sequence ID" value="GCB70010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PA88"/>
    <dbReference type="STRING" id="75743.A0A401PA88"/>
    <dbReference type="OMA" id="GYRETSC"/>
    <dbReference type="OrthoDB" id="10072647at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18207">
        <property type="entry name" value="BTB_POZ_ZBTB19_PATZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000780">
        <property type="entry name" value="myc-associated zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000404">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000945">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000095">
        <property type="entry name" value="Vascular endothelial zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16637">
        <property type="entry name" value="zf-C2H2_assoc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="610"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="548"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="671"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB70010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="78217" checksum="73A98F5F93AB7563" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBE6</accession>
    <name>A0A401PBE6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polycystin cation channel PKD1/PKD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0005676</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001805">
        <property type="protein sequence ID" value="GCB70429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBE6"/>
    <dbReference type="STRING" id="75743.A0A401PBE6"/>
    <dbReference type="OMA" id="ENSDAYQ"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000055">
        <property type="entry name" value="Polycystic kidney disease 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="16">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB70429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="238" mass="28132" checksum="0BB4796C17D71F39" modified="2019-05-08" version="1" fragment="single">FSLLAIFYNIYRTIKVTLLLEQLLENSDAYQNLYFLAFWQNRYNIIIAFTVFIAWIKIFKYISFNMTMTQLSTTLSRCAKGIVGFAIMFFIVFFGYAQLGYLIFGTQVEQYHTFGNCMIILGDFDFHAIEQANQILGPIYFITFVFSLFFVLLRTLHRQNIADKYYHSDSAQEPSANQKHVKNSNQINAKDYQFLMMRTDQLEEKMNEMSLKMDWVMEQLEKQRPVQNRKQAATDITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBG8</accession>
    <name>A0A401PBG8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Eyes absent homolog</fullName>
            <ecNumber evidence="15">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0008586</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01003320">
        <property type="protein sequence ID" value="GCB70468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBG8"/>
    <dbReference type="STRING" id="75743.A0A401PBG8"/>
    <dbReference type="OMA" id="QCASANN"/>
    <dbReference type="OrthoDB" id="167668at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02601">
        <property type="entry name" value="HAD_Eya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12350:FF:000001">
        <property type="entry name" value="Eyes absent homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042577">
        <property type="entry name" value="EYA_dom_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF11">
        <property type="entry name" value="EYES ABSENT HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 15" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB70468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="376" mass="42063" checksum="273C5558330431A2" modified="2019-05-08" version="1" fragment="single">DYSYAGFGQGQYAQYYNNSPYPSPYISNNNSPTTPSTATTYQLQDIPTVTSQAVTDSATGEFGTIHSSSTSIKDAESDRLRRASDGKSRGRGRRNNPSPPPDTDLERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFATDGFHAAATSANLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPTKRESWLQLRAEIEALTDSWLTLALKVLTLIHSRSNCINILVTTTQLIPALAKLLLYGLGIVFPIENVYSATKIGKESCFERIIQRFGRKVVYVVVGDGAEEEQASKKHTMPFWRISSHSDLMALHHALELEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC58</accession>
    <name>A0A401PC58_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0001346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000299">
        <property type="protein sequence ID" value="GCB70697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC58"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="80" mass="8683" checksum="0DACDA4932E79B8A" modified="2019-05-08" version="1">MDDHRSDKIIAPGVKDDHRSDKIIVTGVTDDHRSDVTYRSDITGTTTQVKQDIAGAHSTDGIDVTYGWTWSGLLAADGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCC4</accession>
    <name>A0A401PCC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dorsal root ganglia homeobox protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Paired-related homeobox protein-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0005772</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with RGMB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001849">
        <property type="protein sequence ID" value="GCB70776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCC4"/>
    <dbReference type="STRING" id="75743.A0A401PCC4"/>
    <dbReference type="OMA" id="DTFANHA"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000126">
        <property type="entry name" value="dorsal root ganglia homeobox protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF542">
        <property type="entry name" value="DORSAL ROOT GANGLIA HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="16">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB70776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="269" mass="29734" checksum="C5E1A000BFB49EC6" modified="2019-05-08" version="1">MFYFHCPPQLDGECCRTNSLNSASFGGHGTGDFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGNSDQEAGKEIAAEGSPPMRNLNSPSQLEPNRNKKESLEMQQSLGRTVGPTAPFFPSCLPTTLLNTATYAQALTQVATLKGNSLCSCCVPDPMGLSFLPPYGCQSNRTASVAALRMKAREHSEAVLQSANLLPTANSSPAVGPKPSLDSEQEKASHPKEKIEAERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PCM8</accession>
    <name>A0A401PCM8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003381">
        <property type="protein sequence ID" value="GCB70874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PCM8"/>
    <dbReference type="STRING" id="75743.A0A401PCM8"/>
    <dbReference type="OrthoDB" id="6256369at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040171">
        <property type="entry name" value="USBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347">
        <property type="entry name" value="COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347:SF5">
        <property type="entry name" value="HARMONIN-BINDING PROTEIN USHBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB70874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="187" mass="21580" checksum="586C3C4A38CA88A4" modified="2019-05-08" version="1">MNYQDEMSWLKGQLSWVKKERRDLEQSLRSQESQEVAAILLLAHWQAEREECLQGKSIADCVKEETPPSEALAICGDQRVSELTAASTREKQLREHIEELVTSLEKLIRNNNIEKDQSEELISELRKTYSNLSTAYRNTKRKYENQLSKLESQVSTMSERQAAQIQSLEGRARRLQEELDNANGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PE08</accession>
    <name>A0A401PE08_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0008811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003448">
        <property type="protein sequence ID" value="GCB71335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PE08"/>
    <dbReference type="STRING" id="75743.A0A401PE08"/>
    <dbReference type="OMA" id="TELCAPQ"/>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17679">
        <property type="entry name" value="RUN_PLEKHM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047326">
        <property type="entry name" value="RUN_PLEKHM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="13">
        <location>
            <begin position="43"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="559"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="711"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB71335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1083" mass="122156" checksum="A8C426A99A098D47" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PF61</accession>
    <name>A0A401PF61_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001980">
        <property type="protein sequence ID" value="GCB71767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PF61"/>
    <dbReference type="STRING" id="75743.A0A401PF61"/>
    <dbReference type="OMA" id="RNGWRYM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="80"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="340" mass="36936" checksum="0CF6CB9BABF2F4CE" modified="2019-05-08" version="1" fragment="single">MSRKVSDAECSLRDLSGERWIRPEGERQAPGERTLIRAADGGGNSNNNRPSTAMTAGAELERAARRQFQGGDNPRFIYLLATFAALGGFLFGYDTGVVSGALLLLKKEFALSQLWQELVVSATVGAAAVSALAGGLLNGYWGRRPCILLASFLFTAGAVVMTASGDRYTLLTGRIVVGLGIGLASMTVTVYIAEAAPSHLRGRLVTINTLFITGGQFFASVIDGAFSYLERNGWRYMLGLSAIPAIIQFVGFLFLPESPRWLMQKGKTQKARRVLSQIRGTQNIDDEYEFIKNNIEEEEREAAGGDTVLWKMITYPPTRRALIVGCGLQLIQQLSGINTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PFQ4</accession>
    <name>A0A401PFQ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein unc-13 homolog A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0001771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000410">
        <property type="protein sequence ID" value="GCB71970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PFQ4"/>
    <dbReference type="STRING" id="75743.A0A401PFQ4"/>
    <dbReference type="OMA" id="CECHNSS"/>
    <dbReference type="OrthoDB" id="5831756at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20859">
        <property type="entry name" value="C1_Munc13-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08394">
        <property type="entry name" value="C2A_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000031">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF1">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="544"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1120" mass="128267" checksum="1B611ADAD4EB7829" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PG64</accession>
    <name>A0A401PG64_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0001831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000426">
        <property type="protein sequence ID" value="GCB72111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PG64"/>
    <dbReference type="STRING" id="75743.A0A401PG64"/>
    <dbReference type="OMA" id="CERAKSN"/>
    <dbReference type="OrthoDB" id="7788762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19696">
        <property type="entry name" value="bHLH-PAS_AhR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000041">
        <property type="entry name" value="aryl hydrocarbon receptor repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF9">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB72111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="123" mass="14062" checksum="5370C0FC2A85D7FD" modified="2019-05-08" version="1">MNSGSIYASRKRRKPVQKSVKTQACERAKSNPSKRHRDRLNAELERLASLLPFPQDVVAKLDKLSVLRLSVSYLRAKSFFNGTVEPEPFEFNIAKTKTIQFDFLCTLTSQFYAGDLFQFNVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGX8</accession>
    <name>A0A401PGX8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0006281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with USP12; promotes translocation of USP12/WDR20 to the plasma membrane. Component of the USP12/WDR20/WDR48 deubiquitinating complex. Interacts with USP46; contributes to the cytoplasmic localization of the USP46/WDR20 complex. Component of the USP12/DMWD/WDR48 deubiquitinating complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002088">
        <property type="protein sequence ID" value="GCB72387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGX8"/>
    <dbReference type="STRING" id="75743.A0A401PGX8"/>
    <dbReference type="OMA" id="WISEIAF"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000101">
        <property type="entry name" value="WD repeat-containing protein 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="404"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB72387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="589" mass="64979" checksum="DCF0BD52F48E639A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH72</accession>
    <name>A0A401PH72_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0006325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002113">
        <property type="protein sequence ID" value="GCB72480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH72"/>
    <dbReference type="STRING" id="75743.A0A401PH72"/>
    <dbReference type="OMA" id="TTSHCKW"/>
    <dbReference type="OrthoDB" id="5960344at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14982">
        <property type="entry name" value="7tmA_purinoceptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000017">
        <property type="entry name" value="lysophosphatidic acid receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047160">
        <property type="entry name" value="GP183-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24237:SF37">
        <property type="entry name" value="COAGULATION FACTOR II (THROMBIN) RECEPTOR-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24237">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="34"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB72480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="332" mass="38482" checksum="9C6A0709452B29F0" modified="2019-05-08" version="1">MTNSSDANCTLEANFQYYLFPVVYSIVFILGLIGNVLALCLMTKEMKKASPSYVYITNLVVIDLIYICTLPFRIHYHTRRNDWSFGDVACRITGTLYFANVYISIAFLSLICLDRYIAVVHPRKYIRMKNTHFSKFISVLVWVLSMTIMLPLVFSGSFNNTSKNNITACFENFDPNTWNKRMAAYNVVVLVFGFSIPFTVIVIFYPLAAKKIAQLKSSATCEKALTMIRVILVISVVCFVPYHVTHFLYFLTRLNVIQNCAFARFLYRFRRITMALASLNSALDPMIYYFATAHFKLRSNRKKRSIRQVMTFHRERKSVQRVCTLARQKTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHL6</accession>
    <name>A0A401PHL6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Groucho/TLE N-terminal Q-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0006385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002142">
        <property type="protein sequence ID" value="GCB72620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHL6"/>
    <dbReference type="STRING" id="75743.A0A401PHL6"/>
    <dbReference type="OMA" id="PIWIHTI"/>
    <dbReference type="OrthoDB" id="2624652at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000001">
        <property type="entry name" value="transducin-like enhancer protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF24">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="9">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB72620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="726" mass="78304" checksum="538F1578C2B11E07" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHV0</accession>
    <name>A0A401PHV0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0006413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002155">
        <property type="protein sequence ID" value="GCB72669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHV0"/>
    <dbReference type="STRING" id="75743.A0A401PHV0"/>
    <dbReference type="OMA" id="CREPMLR"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000003">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000382">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB72669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="577" mass="64821" checksum="3B55F263A516977D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIG0</accession>
    <name>A0A401PIG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0006512</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01002208">
        <property type="protein sequence ID" value="GCB72878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIG0"/>
    <dbReference type="STRING" id="75743.A0A401PIG0"/>
    <dbReference type="OMA" id="AIKQWQV"/>
    <dbReference type="OrthoDB" id="1870062at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19845">
        <property type="entry name" value="Bbox1_TIF1a_C-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05502">
        <property type="entry name" value="Bromo_tif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15624">
        <property type="entry name" value="PHD_TIF1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000123">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000074">
        <property type="entry name" value="Tripartite motif containing 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915:SF4">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR 1-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 19" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="24">
        <location>
            <begin position="123"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="24">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="22">
        <location>
            <begin position="804"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="21">
        <location>
            <begin position="894"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="623"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="756"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="993"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB72878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115260" checksum="D3D6300CCB37B5A3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJA4</accession>
    <name>A0A401PJA4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRPM-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0002403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000604">
        <property type="protein sequence ID" value="GCB73196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJA4"/>
    <dbReference type="STRING" id="75743.A0A401PJA4"/>
    <dbReference type="OMA" id="WCIAFMI"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF7">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB73196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="401" mass="47316" checksum="57E8006E9DEDED65" modified="2019-05-08" version="1">MRRGRKTAKKREEDVDIDLDDPEINHFPYPFHELMLWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKSMAHEASENDMVDDISQELNHNSREFAQLAVELLDQSYKQEEQMAMKLLTYELKNWSNSTCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRIRKNSSLKVILGILLPPSILSLEFKNKNEMSYMPHSQESALLGKEMEEPEKPAKDKDEEDMEFTAMLDGVNGESARKKNEEEVPTVHRMIPFGRKIYEFYNAPIVKFWFHTLAYFGYLMLFNYIVLVKMERWPSVQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNITDLMAILLFSIGMVLRLQEQPFMSYGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJQ2</accession>
    <name>A0A401PJQ2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">GDNF-inducible zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0006734</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002322">
        <property type="protein sequence ID" value="GCB73357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJQ2"/>
    <dbReference type="STRING" id="75743.A0A401PJQ2"/>
    <dbReference type="OMA" id="PFMCESC"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000709">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003027">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000701">
        <property type="entry name" value="Zinc finger and BTB domain containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
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        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB73357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="93614" checksum="FCE73E452D6B06D2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMC5</accession>
    <name>A0A401PMC5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat and IQ domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0003343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000899">
        <property type="protein sequence ID" value="GCB74255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1176"/>
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        </location>
    </feature>
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        <location>
            <begin position="186"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="295"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB74255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1747" mass="201819" checksum="3CC09C0FBD2120EA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PME7</accession>
    <name>A0A401PME7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Troponin I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0003364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the troponin I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000906">
        <property type="protein sequence ID" value="GCB74275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PME7"/>
    <dbReference type="STRING" id="75743.A0A401PME7"/>
    <dbReference type="OrthoDB" id="371899at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000002">
        <property type="entry name" value="troponin I, fast skeletal muscle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF38">
        <property type="entry name" value="NOVEL PROTEIN (ZGC:92233)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="136"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="358"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB74275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="59317" checksum="42F6E76A3275425A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PMX0</accession>
    <name>A0A401PMX0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malic enzyme N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0003582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000990">
        <property type="protein sequence ID" value="GCB74492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PMX0"/>
    <dbReference type="STRING" id="75743.A0A401PMX0"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF17">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="3">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB74492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="231" mass="26450" checksum="AB03CFDC5999D6A2" modified="2019-05-08" version="1" fragment="single">ALARCALRSSRWALTPLQLSSTSFVSPFQNLEMAKQELGDWELQKPQKSSKNSVYTRRKGCDIIRNPLLNKGLAFTLEERLQLGIHGLLPPCIFDQNTQVVQVLKNYERKKDDLDRYIFLIALQDRNEKLFYRVLASDIERFMPIVYTPTVGLACQQYGLAFRRPRGLFITIHDRGHIATLLKSWPENDVQFAQRMLNTRPERLGKEICSQITPTNPLGANSHKQGGLTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQQ6</accession>
    <name>A0A401PQQ6_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0015323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008644">
        <property type="protein sequence ID" value="GCB75451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQQ6"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB75451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="53" mass="6186" checksum="FFAADF7DD9338C29" modified="2019-05-08" version="1" fragment="single">MLPEKVVLCGIQGERSSVPLYKDQVPDDKKLHNITWKEKFLRNKLSTANIYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSL7</accession>
    <name>A0A401PSL7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0017422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011309">
        <property type="protein sequence ID" value="GCB76092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSL7"/>
    <dbReference type="STRING" id="75743.A0A401PSL7"/>
    <dbReference type="OMA" id="TTTGMMK"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB76092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="299" mass="34151" checksum="6B867B6C95A374A4" modified="2019-05-08" version="1">MGICVSKNVSKEKLRKTIKRQGAAPSEEEDALLVAELRSQLKMVYGRNSLGLAMMEMSEIPEIAWQVIEVEKLNVSHNFLLSIGPGIENLQNLTILNLLGNQLATLPKEIGMLRKLRVLFADWNCLKEVPHELGHCKKLQVLSLSYNMISSLPESLEDLRKLEKLNLSNNRFVQLPTCVYRMRRLTFLHLGCNKIESISESVGQLESMRIFIAEKNRLRFLPKSICLMRPLKLLNVNYNEIENLPTNLPMLTELERIACHSLDTGLHVKCNPLAKPLLDLVEEGLEPLFDYLKPKRDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWW1</accession>
    <name>A0A401PWW1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM151A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0016718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the menorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010293">
        <property type="protein sequence ID" value="GCB77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWW1"/>
    <dbReference type="STRING" id="75743.A0A401PWW1"/>
    <dbReference type="OrthoDB" id="413402at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019356">
        <property type="entry name" value="Menorin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184">
        <property type="entry name" value="MENORIN (DENDRITIC BRANCHING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184:SF4">
        <property type="entry name" value="PROTEIN FAM151A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10223">
        <property type="entry name" value="Menorin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Menorin-like" evidence="8">
        <location>
            <begin position="85"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="192" mass="21470" checksum="D810900370C9CF36" modified="2019-05-08" version="1" fragment="single">MLHPASDQEFLYKDGKDGPSIRRRWKLLGGLFFASLVAAYLGLVGYFAVYRDFFPDRGFKVDGSFSPGGDLLDYLLQHGMIDRKDGLLVTWHHAANSKSQMEKALKGSAMVLEADVNIEGLNTPNETGTPIMAHPPDVYSDNTLQEWLDAVIQSKKGIKLDFKSIHAVNPSLDILVKKYNEVSFNRPVWLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXW9</accession>
    <name>A0A401PXW9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0015741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009076">
        <property type="protein sequence ID" value="GCB77950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXW9"/>
    <dbReference type="STRING" id="75743.A0A401PXW9"/>
    <dbReference type="OMA" id="KEMALYT"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44523">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44523:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019303009" evidence="2">
        <location>
            <begin position="29"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB77950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="832" mass="93997" checksum="BA9444F3BE4F4A40" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PYL7</accession>
    <name>A0A401PYL7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009122">
        <property type="protein sequence ID" value="GCB78196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PYL7"/>
    <dbReference type="STRING" id="75743.A0A401PYL7"/>
    <dbReference type="OMA" id="VDPRSCK"/>
    <dbReference type="OrthoDB" id="10251209at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000538">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB78196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="367" mass="41154" checksum="BBC76587C6715A74" modified="2019-05-08" version="1" fragment="single">PASSGSGWSRVAAPSGAGGAGFRCEAESFSWRRLGTMDSKGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTAKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLDVDSKNCKILLTEPPMNPTKNREKIIEVMFETYQFSGVYIAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMMKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRVIKVGGERFEAAEALFQPHLINVEGKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDSFWLTRQEYQEKGVRVLEKLGVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZN4</accession>
    <name>A0A401PZN4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0018636</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013154">
        <property type="protein sequence ID" value="GCB78617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZN4"/>
    <dbReference type="STRING" id="75743.A0A401PZN4"/>
    <dbReference type="OMA" id="DCHTQMM"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21583">
        <property type="entry name" value="KLF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000237">
        <property type="entry name" value="Krueppel-like factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF156">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB78617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="391" mass="43961" checksum="5275E5F05AABE0F0" modified="2019-05-08" version="1">MALTSTMLPSIATFTTPKSWDKQEYCNKWKIDPRVKQPQVDCSVTDFMQYLDHFSRASDAVDDLSLLDVDFILSNTMCTDSAGSVDYSLPEEECAPFYQKSDSLAYNVPEAGEPPAYSLMAELLRSDTDYYPPSGVQGRFLLTPAFPTEDLAKVPKTEPGLEGYGQGMGMVPSPACFRIKQEDTVSCMVAYSEQQQRLSSSPHGGGGSVTPPLSPDDLMSSECQQQQQVMCHPGGGVPYPASYPFAHHHHHHQMHYPNQYGLFDDTVALQPSPAQRLMLTPPSSPLELLDSKPKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCTWEGCGWKFARSDELTRHYRKHTGHRPFQCHMCERAFSRSDHLALHMKRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0L9</accession>
    <name>A0A401Q0L9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="1">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0015902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01009258">
        <property type="protein sequence ID" value="GCB78908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0L9"/>
    <dbReference type="STRING" id="75743.A0A401Q0L9"/>
    <dbReference type="OMA" id="MREVMID"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000097">
        <property type="entry name" value="spermatogenesis-associated protein 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="8">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="386"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB78908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="627" mass="68372" checksum="1DF2B0C36A886B38" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0N2</accession>
    <name>A0A401Q0N2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferritin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0018682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013238">
        <property type="protein sequence ID" value="GCB78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0N2"/>
    <dbReference type="STRING" id="75743.A0A401Q0N2"/>
    <dbReference type="OMA" id="NHLVNIE"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000002">
        <property type="entry name" value="Ferritin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014034">
        <property type="entry name" value="Ferritin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF54">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00540">
        <property type="entry name" value="FERRITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00204">
        <property type="entry name" value="FERRITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="2 9" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="10">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="176" mass="20611" checksum="BA0DF42F2D66CA84" modified="2019-05-08" version="1">MASQVRQNYHKDCEDAVNKQINLELYSSYVYLSMSSYFDRDDVALRHFAEFFKEQSHEEREQAEKLMEFQNKRGGRFVLEDIKKPEQDEWSNGLEAMQRALQMEKNVNQSLLDLHKLSSGKTDPHLCDFLETHYLDEQVKMIKKLGDHITNLKRLGAPENGTGEYLFDKLTLGETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3F2</accession>
    <name>A0A401Q3F2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0016049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009455">
        <property type="protein sequence ID" value="GCB79851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3F2"/>
    <dbReference type="STRING" id="75743.A0A401Q3F2"/>
    <dbReference type="OMA" id="RWWHEEY"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="1">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB79851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="173" mass="19927" checksum="50DD16E61658F525" modified="2019-05-08" version="1" fragment="single">MRIYEAHVGIASPEGKVASYKNFTQNVLVRIKNLGYNCIQLMAIMEHAYYASFGYQVTSFFAASSRFGTPEELKELVDTAHSMGLFVLLDVVHSHASQNTEDGLNAFDGTDSCFFHSGTRGTHPQWDSRLFNYSNWEVLRFLLSNLRWWVEEYYFDGFRFDGVTSMLYHHHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3F8</accession>
    <name>A0A401Q3F8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Calcium and integrin-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Calmyrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0017034</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Filopodium tip</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010754">
        <property type="protein sequence ID" value="GCB79898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3F8"/>
    <dbReference type="OMA" id="NEMEMRI"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-membrane adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:spermatogenesis"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF3">
        <property type="entry name" value="CALCIUM AND INTEGRIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0221">Differentiation</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0519">Myristate</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00040936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00041782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB79898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="93" mass="10949" checksum="21323669C47AFF16" modified="2019-05-08" version="1">MKDKDETLLQVEKEKRNFNDNGAIDRSDLSQFLTLITGNEIHKTLNEMEMRIIIDMIMEDIDMDGDERINLSEFHHIASKMPDFASYFTMTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q488</accession>
    <name>A0A401Q488_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0018884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01013557">
        <property type="protein sequence ID" value="GCB80143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q488"/>
    <dbReference type="STRING" id="75743.A0A401Q488"/>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060997">
        <property type="term" value="P:dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF9">
        <property type="entry name" value="CATENIN DELTA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="115" mass="12431" checksum="A4AED6582D8DF6CB" modified="2019-05-08" version="1">MMNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTIENCVCILRNLSYRLAAETAQGQQMGTDEFDGLLCSDSNGKDSESSGCWGKKKKKKKGQNQVISGPSSTGEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q4X6</accession>
    <name>A0A401Q4X6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Sodium-coupled neutral amino acid symporter 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Amino acid transporter A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Solute carrier family 38 member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">System A amino acid transporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">System A transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">System N amino acid transporter 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">scyTo_0016202</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29283"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:29285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:71383"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:71385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68236"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:68238"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:71583"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:71585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29263"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:29265"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68240"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:68242"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68244"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:68246"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:28969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29575"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:29577"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69999"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:70001"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68228"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:68230"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01009651">
        <property type="protein sequence ID" value="GCB80436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q4X6"/>
    <dbReference type="STRING" id="75743.A0A401Q4X6"/>
    <dbReference type="OMA" id="AFHACEM"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF207">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID SYMPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="34">
        <location>
            <begin position="71"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00039205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00041835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00041859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00041916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00042516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00042868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="GCB80436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="519" mass="57665" checksum="D27632A51C20449E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q5D0</accession>
    <name>A0A401Q5D0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011011">
        <property type="protein sequence ID" value="GCB80562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q5D0"/>
    <dbReference type="STRING" id="75743.A0A401Q5D0"/>
    <dbReference type="OMA" id="SFICEAY"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08967">
        <property type="entry name" value="MeNeil1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.190.10:FF:000003">
        <property type="entry name" value="endonuclease 8-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF27">
        <property type="entry name" value="ENDONUCLEASE 8-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="1">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB80562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="218" mass="24595" checksum="C88A6C544C7FC57B" modified="2019-05-08" version="1">MEIGHPVSPLRLDFKMPEGPELHLASRFVNRVCSGTVFAGQVEKSAVSKNCEVPFKCDAYLISAVSRGKEVKLTLTPIKEEDGKEDMKPTATEDEDRLLAPMDVTFRFGMSGSFKLTNEDEVPKHAHLKFFTKGKPTQVLCFVDPRRFGSWEVNGTWQSDRGPCVLLEYEKFRYKCPSFPSEILASPAGRVCVVCGCVWEDWCVLCVFLCCYPMTLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q675</accession>
    <name>A0A401Q675_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01025035">
        <property type="protein sequence ID" value="GCB80875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q675"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="7683" checksum="AC8478DFAE16A226" modified="2019-05-08" version="1" fragment="single">MLSEHLSQEIHQLLTEVKGMAVVLNEYFAFAFTKLEDGGNGPVENVGVEQLSRIVIDEEKVLKRLAGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8F1</accession>
    <name>A0A401Q8F1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0022818</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01024254">
        <property type="protein sequence ID" value="GCB81644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401Q8F1"/>
    <dbReference type="OMA" id="PDNDPFH"/>
    <dbReference type="OrthoDB" id="2121937at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000016">
        <property type="entry name" value="Polycystin family receptor for egg jelly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF1">
        <property type="entry name" value="PLAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019214550" description="PLAT domain-containing protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1499"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1705"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1735"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1923"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1955"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2052"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2311"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2347"/>
            <end position="2369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2389"/>
            <end position="2413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2433"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2497"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="12">
        <location>
            <begin position="530"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="11">
        <location>
            <begin position="1542"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1773"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1807"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1850"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1868"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1879"/>
            <end position="1900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB81644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2597" mass="292675" checksum="099D4BA584D68CB3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q9I4</accession>
    <name>A0A401Q9I4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0022266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021870">
        <property type="protein sequence ID" value="GCB82016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q9I4"/>
    <dbReference type="STRING" id="75743.A0A401Q9I4"/>
    <dbReference type="OrthoDB" id="9944459at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF21">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 2 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB82016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="245" mass="27154" checksum="AA35E8E95C26CE14" modified="2019-05-08" version="1" fragment="single">VSFQHETYPAPAIGPERGPVEPSAPELEEQPIARQVFIVQELEIRDRLAASQINKFLYLYTSEKMPRRAHSNMLTIKALHVRPESGLGGPECCLRVSLMPLRLNIDQDALFFLKDFFTSFATGINPVVPVETATEAKPDPGQRAGRAFDADSAGRDTDPAPSLPEMTASMETTFSEQSSSSTASSSSEQPIYFREFRFTSEVPIWLDYQGKHVTMDQGTFAGILIGLAQLNCSELKLKRLCCRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QA11</accession>
    <name>A0A401QA11_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01027235">
        <property type="protein sequence ID" value="GCB82223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QA11"/>
    <dbReference type="STRING" id="75743.A0A401QA11"/>
    <dbReference type="OMA" id="NIWRQSS"/>
    <dbReference type="OrthoDB" id="9987665at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28278" checksum="D9EBF8FBF9D35A5B" modified="2019-05-08" version="1" fragment="single">QFSKVFDELCPALEDMLAQGHMGIITELAAACVKHKAKQAELLTKLYQAFHCCQPASRRTACSPLFVSLLTYEIFYGLGDEDVTTEHQPSEEQRLSSISYHGSLLTQHLLHFDEPAPVTLSLAAMPQGDQVKLACDQAGSHVFDALLTSGTVSDKQRRKVLRKLEGQFMQLACDRHGSRVLDQIWGSASLKAKQTIAAELASRESELWGDPIGHHIARNLALTHFVKRRREWDEHQAAESKRRKMFAELLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QB20</accession>
    <name>A0A401QB20_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0022029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020900">
        <property type="protein sequence ID" value="GCB82583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QB20"/>
    <dbReference type="STRING" id="75743.A0A401QB20"/>
    <dbReference type="OMA" id="QHIDKEQ"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB82583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="129" mass="13972" checksum="1AD8615200FCB620" modified="2019-05-08" version="1" fragment="single">VAPFSGATTGTGGRIRDIQCTGRGAHAIAGIVGYCFGNLLCPEYPQPWEDQTFIYPENFARPLEVAIEASNGASDYGNKFGEPVLAGFARSFGLLLPGQERREWVKPVMFSAGIGTIEDQHIDKEQPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBI3</accession>
    <name>A0A401QBI3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01037402">
        <property type="protein sequence ID" value="GCB82755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBI3"/>
    <dbReference type="OrthoDB" id="10060000at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB82755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="10437" checksum="54BF69ECC272E30F" modified="2019-05-08" version="1" fragment="single">MTRPLSLCQATSDDGLSNFFTAATKIASDLNGAVTPKGETKVSGLERSQERNQGSDKDPLLVPSLPTEPVPQAAAANSAQTPARSQAQAETAASAPTGSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBK2</accession>
    <name>A0A401QBK2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0024005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01037389">
        <property type="protein sequence ID" value="GCB82753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBK2"/>
    <dbReference type="STRING" id="75743.A0A401QBK2"/>
    <dbReference type="OMA" id="PMLEMFE"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042420">
        <property type="entry name" value="RAI14/UACA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24129">
        <property type="entry name" value="ANKYCORBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24129:SF2">
        <property type="entry name" value="DUF3447 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="261"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="417"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB82753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="503" mass="58114" checksum="EC6D52BFCF39C8E6" modified="2019-05-08" version="1" fragment="single">ELEYLQKGTNEGDSSGSLDFVPVLLYDSLQAEFEKLKEQHEQAQTTIREEVNSEKLVSLEAYEQLKVEHGQEVQRLQEVLDELKAKTDSKVEDSSRDERLEVKDMAEHGSQDVEELIKKLKDTQHKYEAAMSEIQQLEEQIQLGILSVEEKATMRNTGTIKTIPGEESVKMELLRADNTEVEEERKMKTLEEKVNEMEKVLTHSVPLEEYNEMRMSLNISLEEISKQNLLLVEKYTKAEGELEDQKRSHFGESPENGTGASIEAKEQLGELNKAHNELQEKYRELQTEYEKEVEELKSIQSLYVPKEDHEKVKDKLSKSLNEANNQLHDLKVTHNAIQQEITRLEDEIEQQRKSSICWGEHLKMKESLEKSLQDTKGIVSNMKDQLATKDKEISQRQEEAETMKGQTIRKEEHEKIATSLKDEVNSLIIKLNDLTKKHEKTCTEVFRVQRQALFMKSEKQAAEEEMAAAQKQLSDLKAESTKIIELHKHIEDSAGLVKEKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QCA2</accession>
    <name>A0A401QCA2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0023522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01030237">
        <property type="protein sequence ID" value="GCB83028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QCA2"/>
    <dbReference type="STRING" id="75743.A0A401QCA2"/>
    <dbReference type="OMA" id="PEEDHEY"/>
    <dbReference type="OrthoDB" id="1702031at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1010">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB83028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="644" mass="67972" checksum="96FF91B14A965D41" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QD62</accession>
    <name>A0A401QD62_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0023753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01033381">
        <property type="protein sequence ID" value="GCB83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QD62"/>
    <dbReference type="STRING" id="75743.A0A401QD62"/>
    <dbReference type="OMA" id="KMTHEHT"/>
    <dbReference type="OrthoDB" id="437530at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF46">
        <property type="entry name" value="HOMEODOMAIN-INTERACTING PROTEIN KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="427" mass="48516" checksum="34C0D9C1B5B97094" modified="2019-05-08" version="1">MWSLGCVMAELHLGWPLYPGNSEYDQIRYIVETQGLPKDHLLNAATKANHFFRRNPRQHSVHQWQLKCATDYQAETLVQPLERRKYVLKTLDQLETINITKTVFPDDEVIAEFHDRKNMVELIKRMLTLDSHERITPSAALKHPFVTIQHLKMTHEHTKYYDLSVQGLNVALSCDRRVLADRHYYNMADEAYYPNSDYYECRQAHHIPSISSMQRAIDKMDSLTIEEPGALNMWPEGAGNAGYQPSTSKAGSSTCLPHSYHQGACCRASHPAHRHRKEPVMGYYANRCGMKQRKAPHHSQSDPNFGNVILLGQEPSTEVINWEEEEAGAIFTTPSSLVQEKNRPEEHLATKEPSGPEVNAVKARGNGEVLPRFSGGIQLCKRLIKCFLGKGSAGKYCKTEQMFGFGEHEPGTRACRCRGCLRLWVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QDQ9</accession>
    <name>A0A401QDQ9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B-cell lymphoma 9 beta-catenin binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0024423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01046223">
        <property type="protein sequence ID" value="GCB83457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QDQ9"/>
    <dbReference type="STRING" id="75743.A0A401QDQ9"/>
    <dbReference type="OMA" id="RERXVAP"/>
    <dbReference type="OrthoDB" id="7668649at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015668">
        <property type="entry name" value="Bcl-9/Bcl-9l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024670">
        <property type="entry name" value="BCL9_beta-catenin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15185:SF3">
        <property type="entry name" value="B-CELL CLL_LYMPHOMA 9-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15185">
        <property type="entry name" value="BCL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11502">
        <property type="entry name" value="BCL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B-cell lymphoma 9 beta-catenin binding" evidence="5">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="565" mass="61896" checksum="740BC4784C8279A9" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QE70</accession>
    <name>A0A401QE70_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 102A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0024155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01040261">
        <property type="protein sequence ID" value="GCB83617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QE70"/>
    <dbReference type="OrthoDB" id="5984396at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="52"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB83617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24754" checksum="A8B09156AA3A7094" modified="2019-05-08" version="1">MKRGEAAVSKATQSSRPQASEAPPTPVGQRPSRLLAPALQAEGEGDCWEPALERCRRELLEARSLAANLEKTVRWWSECSARWKEKWAKANLEKVRSRRECQLLRQKVKGLQREVGQLRAALEEKEEEADAAEFHIQERGQRLTNVHGKHRGERGERHSDHQGTASFTEDQGGQATKEEDPGGVLAARLNSKCSLRSAGGPRGGQGMTECRTGQQGESPRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QFJ5</accession>
    <name>A0A401QFJ5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01049522">
        <property type="protein sequence ID" value="GCB84150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QFJ5"/>
    <dbReference type="OMA" id="CIERWEE"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="61" mass="7855" checksum="40B67A1653FBF31E" modified="2019-05-08" version="1" fragment="single">MDGRGHRRIDRCIERWEEKERKKERKEKECKKERKTEGKKKERKNERKKESKREKKKEKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGB1</accession>
    <name>A0A401QGB1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0025097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01071445">
        <property type="protein sequence ID" value="GCB84458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGB1"/>
    <dbReference type="STRING" id="75743.A0A401QGB1"/>
    <dbReference type="OMA" id="SIKQPRG"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB84458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="99" mass="10978" checksum="F163941A72036439" modified="2019-05-08" version="1" fragment="single">INSESKANITCLVYSHDGSDLLASYNDEDIYLFNSSHSDGADYVKRYKGHRNNATVKGVNFYGPRSEFVVSGSDCGHIFLWEKSSCQIVQFMEGDKGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGP7</accession>
    <name>A0A401QGP7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01073242">
        <property type="protein sequence ID" value="GCB84540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGP7"/>
    <dbReference type="STRING" id="75743.A0A401QGP7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF1">
        <property type="entry name" value="ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854">
        <property type="entry name" value="ASAP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB84540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="58" mass="6740" checksum="54D38F4856145018" modified="2019-05-08" version="1" fragment="single">NVAGETALDIAKKFNHVRCEELLDQAQAGKFNPPVHVEYEWVVQQDYTYDSEEDLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGV6</accession>
    <name>A0A401QGV6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intracellular hyaluronan-binding protein 4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0025251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01078825">
        <property type="protein sequence ID" value="GCB84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGV6"/>
    <dbReference type="STRING" id="75743.A0A401QGV6"/>
    <dbReference type="OrthoDB" id="8955733at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032381">
        <property type="entry name" value="IHABP4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16174">
        <property type="entry name" value="IHABP4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intracellular hyaluronan-binding protein 4 N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="12614" checksum="59A940B670023210" modified="2019-05-08" version="1">MKGVILAAAAMQETFGCAVTNRFDQLLDDESDPFDILREAEEKKQKKKKEEGGRKTRAGSGPPIGGTSAAANAASNAAKAGRRESQKARKIPANNEAGGRPGGAGGTENVFTGNSQRREGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QH65</accession>
    <name>A0A401QH65_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0025371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01089122">
        <property type="protein sequence ID" value="GCB84778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QH65"/>
    <dbReference type="OMA" id="ARCTQYF"/>
    <dbReference type="OrthoDB" id="9949627at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35838">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35838:SF1">
        <property type="entry name" value="TRICHOHYALIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB84778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="429" mass="50822" checksum="FF1A0A2EAFE84CA0" modified="2019-05-08" version="1">MEPLYTLLRSEIKKFEKHVEDCRDSFDMVTLSRFLSGLTEQDAENVDSLQRVRHLANHLAKAKLPFKDSRSDIDNYISWLSAYMDYLRVLKEAFDDRIVIPLCENLYVNEDTESHRISSDSSNCSSPVSSKASSQKEWMKLPRTYQTAQPEVPMDSIPKIAKELFNVRRRWTLLLTNDTIKDEYFNPQSIADLCRMNTPEHLKKVLRLIPDIFYKCLLTADLSRQWLDLHECRYGLLNFPVAETKDFHTEGTTRKLCLVTAKQLSTHKEAKLMQSRDSQAVQTTSQESSEELDDVHCMKTRMEQEDLNFLVRREERLKTLEKETREAGFRVHDLLSQLELVKQENEQLQQRWDFEELQRTEEGVIKRKHRTNLRQMEELQRQLKLQKYRYRILEGDWMLELEIRPLLIRHMDTVSEGSAERRTATTWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHZ8</accession>
    <name>A0A401QHZ8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01115886">
        <property type="protein sequence ID" value="GCB85009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHZ8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="223" mass="26028" checksum="A1A75C883C77C631" modified="2019-05-08" version="1">MELSWRTRNYPGAHQNYPGEHRLSWGTPELSWSTRNWPGEHGIILANTELSWSTWNYPGEHGIILEHTGIILEHPGIILDQTELSQRTRNYPGAHVSILEKTELSWRRRNYHREHGIILGHTGIILENTELSWTTPELSWGTRKYPGEQGIILEHTRIIVENRELSWRPQSYPGAHWNYPGEHGIMLENTGIIQENMELSWRTRNILENTELSCSTPELSWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIU8</accession>
    <name>A0A401QIU8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01146964">
        <property type="protein sequence ID" value="GCB85293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIU8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="31" mass="3619" checksum="A0165B5E1408CBA7" modified="2019-05-08" version="1" fragment="single">FTIQKDRTLFRGIQASLEPERNEEVQLDDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJ68</accession>
    <name>A0A401QJ68_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hemicentin-1-like von Willebrand factor A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0026027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01150514">
        <property type="protein sequence ID" value="GCB85399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJ68"/>
    <dbReference type="STRING" id="75743.A0A401QJ68"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF18">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING 10, TANDEM DUPLICATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Hemicentin-1-like von Willebrand factor A" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB85399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="105" mass="11558" checksum="8F06F73377E266A1" modified="2019-05-08" version="1" fragment="single">LALTNTPPLSHIYVFTDAPAKDHELKDSIQALIEQTKCKVSFLLTNAISRRKRDVNARFGNQLYRVLARVSGGLAVVIQRALISSLTFIIEDSATTALVMLAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QJF7</accession>
    <name>A0A401QJF7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01167324">
        <property type="protein sequence ID" value="GCB85511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QJF7"/>
    <dbReference type="STRING" id="75743.A0A401QJF7"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="105" mass="12720" checksum="236BC09BBF263A79" modified="2019-05-08" version="1" fragment="single">MCSRPTQNDEQDEECDIQINIEELERFVLPSGQEIEKQSQQTPDLKMIYKRMTDTVEVLCDFKRKREQGRERQEYLQLLKRDLATYYSYNEYLIQKLCDLFPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK12</accession>
    <name>A0A401QK12_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0026395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01191474">
        <property type="protein sequence ID" value="GCB85726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK12"/>
    <dbReference type="STRING" id="75743.A0A401QK12"/>
    <dbReference type="OMA" id="VENWERV"/>
    <dbReference type="OrthoDB" id="10254988at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF35">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 88B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB85726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="382" mass="43621" checksum="AC7BE8D25F8569FD" modified="2019-05-08" version="1" fragment="single">RGDILPFDRGSSLFQVQDLKLENERLRQSVEALRQRSQVSAEARVKDIEMENKILHEAMMEASQRQSGLESERKQARLELEQCRERADKAEASARELGRVEKLSEQLRKRALELELSCGRLPVLEERVSGLEAENRRLQKGLEGLAGAQALLEDSEAERSHLEQENLHLRKMVEMQEMDRAIVSQLESENKELGKEKDQLRRTVNQQKASVKRAEDLASAHQDLQAESQRLTRGLENAKRRVSELEGEVEELEARAQSRQLDLEEQRSAAALLEQAREGLEQELEQAEREKRQLGKEARRLRQQAEARDASLDEHHLRVAGLEQENRRLLLLETQRAGEAQDKLREAEAENGELLRRLALGKTESASLREVSAFETRGGGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK34</accession>
    <name>A0A401QK34_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0026383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01190501">
        <property type="protein sequence ID" value="GCB85739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK34"/>
    <dbReference type="STRING" id="75743.A0A401QK34"/>
    <dbReference type="OMA" id="IVWEAYF"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB85739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="140" mass="16239" checksum="92B8A97CFCD4BA26" modified="2019-05-08" version="1">MASSQARVVSTILEKHGYQLGRYLGKGAYAIVWEAYFKKWRTNVAVKVLLKEKAEAEFLSKFLPREIQVWKSLKHPNIINFYQSIETTNRVYIMLELAPRGEVMDIIRMKGACDEKTAGKWFEQLCQGMAYIHSRGVVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QK77</accession>
    <name>A0A401QK77_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01194020">
        <property type="protein sequence ID" value="GCB85723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QK77"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="288" mass="31729" checksum="65EF313F8F49BBEB" modified="2019-05-08" version="1" fragment="single">TLCKDGGDPREGIFESLAEALHPEDIDYGVDDRVDVRQQDQGKRDRSRDFTAWAVKFDAVQDVDGNPAQGETGQDNAEQHCRLDLLMNYLLPPFLGTDANVPLGYPADLLFDLEEYLGVDDEHDEQRQQHAANEIEVDHVAPVDHIVKAAALASDGPSVPPHQRHQPNGHRQRPGRDDRQAGLPGRHPGLVTERLQDGDVAFHGNGKQPKDGSLGQDEQDAEHQDAEGVTAPGQTQVRQQGARDGHGPDQYVRHSQRHQEVIVDGAQLPVPGDGKADKDIPEDSKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKE6</accession>
    <name>A0A401QKE6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactosyltransferase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0026457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01199334">
        <property type="protein sequence ID" value="GCB85822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKE6"/>
    <dbReference type="STRING" id="75743.A0A401QKE6"/>
    <dbReference type="OMA" id="WHVIESK"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006682">
        <property type="term" value="P:galactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF33">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB85822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="162" mass="18837" checksum="B8558BCC0F0CFCA6" modified="2019-05-08" version="1" fragment="single">MGCCNGQEMRSQSLSSVFLTVGPLSIQFDRIPSLAGIEERNPLVQEGGFYTPPHCLPQYRTALIIPHRNRETHLRHFLYYLHPFLQRQQLQYGIYIIHQAGNQTFNRAKLLNVGVKEALRDEEWDCLFLHDVDLIPENDHNLYICDNQNPKHVSIAMNKFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QKS3</accession>
    <name>A0A401QKS3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01228904">
        <property type="protein sequence ID" value="GCB86037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QKS3"/>
    <dbReference type="OMA" id="GQKCGQE"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="91" mass="10584" checksum="18E4564F228EF975" modified="2019-05-08" version="1" fragment="single">ERGQECGQAHGQECGQERGLKREQECEQEREQERDQESDQESDQEREQECEQESEQESEQESEQERGQECGQKCGQEQGQEHGQKCGQEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL13</accession>
    <name>A0A401QL13_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01235771">
        <property type="protein sequence ID" value="GCB86064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL13"/>
    <dbReference type="OMA" id="TEKQERC"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="27013" checksum="8D623DC3B3936ABD" modified="2019-05-08" version="1" fragment="single">RETQRDRDTERPRQRETETQRERQRERDTERERHRERQTQRESDTQRERHRETETQRERHRERDKRDRDTERERHRETETQRERQEIPRHRERHGETETQRERHSERDTERPRHRETEAQRERQRERDKRDRDTERERHRETETQRERQERPRQRERETPRDRDTERPSTEGETERETERERDTERERQRERHRETETQREIDTERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QL48</accession>
    <name>A0A401QL48_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0026791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01240856">
        <property type="protein sequence ID" value="GCB86147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QL48"/>
    <dbReference type="OMA" id="MKINAYL"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="246" mass="29219" checksum="2BBCECE47B59EB9F" modified="2019-05-08" version="1" fragment="single">MFLDLILDLLRDLFQDLFLDLLLDLFLDLLLDQFLDLFLDLDLDLLLDQSVRGSFLDLHLDLFTDLFIDLFLDLFLDLLLDLLLDLFLDLLLDLLLHLFLDLLLELLLDQFLDLFLDLYLDLLLDLLFDLLLDLLIDLLLDLILDLYLDLLMDLFPDRFLDVLMDLFMHLILDLLLDLFLDLLLDFLLDQLLDPLLDLFLDFLLDLLLYLLFDLLLDLFPDLLLDLLLDMLLDLLFDLLLDLLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLK1</accession>
    <name>A0A401QLK1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01260068">
        <property type="protein sequence ID" value="GCB86255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLK1"/>
    <dbReference type="STRING" id="75743.A0A401QLK1"/>
    <dbReference type="OrthoDB" id="114660at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="66" mass="7464" checksum="818F9BF7CDCF0382" modified="2019-05-08" version="1" fragment="single">SRVPDKPSSLHVRPLINNIVVSWTPPDNQNIVVRGYAIGYGIGSPHAETIRVDYKQRYYTIENLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLT1</accession>
    <name>A0A401QLT1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01271422">
        <property type="protein sequence ID" value="GCB86330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLT1"/>
    <dbReference type="STRING" id="75743.A0A401QLT1"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="62" mass="7308" checksum="B8D73DD648944994" modified="2019-05-08" version="1" fragment="single">HEDDVQHFKVLRDGKGHYFLWSEKFDSLNKLVEYYKGSSISKTTQIYLRDSKKEAKVRTGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNB5</accession>
    <name>A0A401QNB5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01357784">
        <property type="protein sequence ID" value="GCB86798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNB5"/>
    <dbReference type="STRING" id="75743.A0A401QNB5"/>
    <dbReference type="OMA" id="ERFCTHV"/>
    <dbReference type="OrthoDB" id="9981301at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="71" mass="7935" checksum="BDB5AB075436A7CE" modified="2019-05-08" version="1" fragment="single">MLQLAALVYSLLPARTQYDSCKSLVNTDDAGPSWEFYACQPRPVPMKRYLRVKVEPAGVTCGDPPERFCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNF8</accession>
    <name>A0A401QNF8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01387480">
        <property type="protein sequence ID" value="GCB86959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNF8"/>
    <dbReference type="OrthoDB" id="10597420at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="182" mass="20928" checksum="BEC9A1EA237917D9" modified="2019-05-08" version="1" fragment="single">GWFASLEKGWFASLEKRWFAGLEKERFACLDKGRFASLEKGLFSDLEEGRFASFEKGRFASLEKGRFASFQKGRFASFEKGQFASLEKGRFASLEKGRFASLEKERFTGLERGRFDSLEKGRFASLKKGRFASLEKGWFASLEKERFASLEKGRFASLEKGWLRSLENGRFASLEKRRFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QP37</accession>
    <name>A0A401QP37_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01415297">
        <property type="protein sequence ID" value="GCB87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QP37"/>
    <dbReference type="OMA" id="GECIPAP"/>
    <dbReference type="OrthoDB" id="8960535at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="158" mass="15981" checksum="95C8D37AF3AF543A" modified="2019-05-08" version="1">MDNGNGIQTLCNGNEIQALCNGNGIKTLGNGNEIQALCNGNSIQTPCNGNGIQTLCNGNGFQALCNGNGFQALSNGNEIQALCNGNVIQALCNGNGIQSLDNGNGIQTLCNGNGIQTLCSGNGIDALRNGNGIQALYNGNELQALSNGNGIHALCNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QPA7</accession>
    <name>A0A401QPA7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Single-strand-selective monofunctional uracil-DNA glycosylase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0027940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01435500">
        <property type="protein sequence ID" value="GCB87220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QPA7"/>
    <dbReference type="STRING" id="75743.A0A401QPA7"/>
    <dbReference type="OMA" id="EYAWESH"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017065">
        <property type="term" value="F:single-strand selective uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039134">
        <property type="entry name" value="SMUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235">
        <property type="entry name" value="SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235:SF2">
        <property type="entry name" value="SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB87220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10213" checksum="EBFEBB717063BD42" modified="2019-05-08" version="1" fragment="single">METRGLPFPGAWGEGPPALPEGLAGAFLRAELDLNAELRAMVFTQPVCYVYNPLEYAWESHRLYVEMYCRSRKEVLFLGMNPGPFGMVQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGB2</accession>
    <name>A0A401NGB2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0012642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006169">
        <property type="protein sequence ID" value="GCB59960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGB2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB59960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="69" mass="7689" checksum="1E99562AD23F42BC" modified="2019-05-08" version="1">MSLAFGALLLPQVNEEVIESVFHPMIILQNITHADILINWVAARMEVSLHPQLLKSDLDVGCTIHELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKP9</accession>
    <name>A0A401NKP9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007651">
        <property type="protein sequence ID" value="GCB61444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKP9"/>
    <dbReference type="STRING" id="75743.A0A401NKP9"/>
    <dbReference type="OMA" id="LHKPPFH"/>
    <dbReference type="OrthoDB" id="6135709at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF14">
        <property type="entry name" value="EXPORTED REPETITIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="353" mass="43871" checksum="FE61F6E1C91B620B" modified="2019-05-08" version="1">MRNEPDPGSVQRSHSLERQSPECYLPEQPDPEHRVRDPEHSDPEHSDPEHPDPEHPDPEHPDPEHRDPELHDPEQHDPEHRDPEHRDPEHRDPEHRDPERRDPERRDPELHDTEQRDPEHRDPEHRDPEHRYPEHRDPEHRDPEHRDPEHRDPEHRDPEHRDPEHRDPEHRDPEHRYPENRDPEHRDPEHRDPEHRDPEHRDPERRDPERRDPERRDPERRDPERRDPEHRDPELHDPELHDPELHDPELHDPELHDPERRDPERRDPERRDPERRDPERRDPEHRDPEHRDPELHDPERHDPERRDPELHDPEHHDPEHHDPELHDPEHRDPEHRDPEHRDPELHDPELHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKQ7</accession>
    <name>A0A401NKQ7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0014334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007649">
        <property type="protein sequence ID" value="GCB61429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKQ7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="81" mass="8884" checksum="1FB1D380B8A2594F" modified="2019-05-08" version="1">MDQLGRMLLSMRCNSPPYRSLWVGTKFSGRTVCGKLRFESGKDISKNEGAGAFRKHTSAPRIMPLDTAPAENLKAASPASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLP9</accession>
    <name>A0A401NLP9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005135">
        <property type="protein sequence ID" value="GCB61769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLP9"/>
    <dbReference type="STRING" id="75743.A0A401NLP9"/>
    <dbReference type="OMA" id="NWGIERY"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000796">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000004">
        <property type="entry name" value="Actin-like 6A, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000009">
        <property type="entry name" value="Actin-like 6A, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47446" checksum="DC6022F6B4275F7A" modified="2019-05-08" version="1">MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKADFPTAIGMLLERDDGSTPMEIEGDKGKSSGTTYFIDTNSLRVPRENMEVISPLKNGMIEDWDSFQAILDHTYKNHIKSEAGLHPVLMSEAPWNTRAKRERLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQSIVKSPLAGDFISMQCRELFQELNVEIIPPYMIASKESVREGSAPNWKKKEKLPPVTRSWHNYMCNEVIQDFQASVLQVSDSSYDEQVAAQMPSVHYEFPNGYNCDFGAERLRIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIAAGGNTLIQSFTDRLNRELSQKTPPSMRLKLMANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLT7</accession>
    <name>A0A401NLT7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0007117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002521">
        <property type="protein sequence ID" value="GCB61820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLT7"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB61820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8693" checksum="7C8333C18B70CAB7" modified="2019-05-08" version="1">MDIMLNLGSANDVATDDRLLPSFSYLWGYATEVKTLEEEKKIEFAQITLFMNSERIVKINDEVMEEFSLQFVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM37</accession>
    <name>A0A401NM37_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0011401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005158">
        <property type="protein sequence ID" value="GCB61920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM37"/>
    <dbReference type="STRING" id="75743.A0A401NM37"/>
    <dbReference type="OMA" id="ECTRHTT"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18930">
        <property type="entry name" value="bHLHzip_MXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF13">
        <property type="entry name" value="MAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB61920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="223" mass="25154" checksum="66918EE4F9BB2653" modified="2019-05-08" version="1">MSKPKPFYAKPDKQSKAGDMAEYIPCLWTLISRTATISVKSTTETGSGIILSSVCHAVHLIVRLSTHNELEKNRRAHLRLCLERLKELIPLGSECTRHTTLGLLNKAKAHIKKLEDLDRKSLYQIEHLEREHRFLKRRLEQLQGLPENERIRMDSIGSTAFSDRSDSEREEIEVDVESTEFSHGDMDDISTSSISDLDDHSSLQSVGSDEGYSSCSIKLSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NM74</accession>
    <name>A0A401NM74_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005164">
        <property type="protein sequence ID" value="GCB61976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NM74"/>
    <dbReference type="STRING" id="75743.A0A401NM74"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB61976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="114" mass="12777" checksum="D36F78EBD1F22D92" modified="2019-05-08" version="1">MVMIQVTGKFQGGVNPFTQGCWINISSVLCSSQAPRYVSREKREFHTPVQTPFLQPLISDPEVTMRLKRTRSKGSLEIMESQSVDAEPPPPPKPELHRYSGLWAHLSPATNEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMM4</accession>
    <name>A0A401NMM4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">cAMP-dependent protein kinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007750">
        <property type="protein sequence ID" value="GCB62099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMM4"/>
    <dbReference type="STRING" id="75743.A0A401NMM4"/>
    <dbReference type="OMA" id="YQDVAMR"/>
    <dbReference type="OrthoDB" id="6380180at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004171">
        <property type="entry name" value="cAMP_dep_PKI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15416">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02827">
        <property type="entry name" value="PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB62099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="7838" checksum="DC7AF443C4E96F32" modified="2019-05-08" version="1">MTDVEPGVTDFVSSGRAGRRNALPDILGSPTGANSSDLPHKLAELSISTDEGEEKTSPSEALPKPPECEEKDNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NND6</accession>
    <name>A0A401NND6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-glutamate cyclase, mitochondrial</fullName>
            <ecNumber evidence="8">4.2.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0004240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glutamate = 5-oxo-D-proline + H2O</text>
            <dbReference type="Rhea" id="RHEA:22360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:57948"/>
            <dbReference type="EC" id="4.2.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.48" evidence="8"/>
    <dbReference type="EMBL" id="BFAA01001242">
        <property type="protein sequence ID" value="GCB62372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NND6"/>
    <dbReference type="STRING" id="75743.A0A401NND6"/>
    <dbReference type="OMA" id="HIGHPGL"/>
    <dbReference type="OrthoDB" id="10262538at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1640.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1640.20:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.20">
        <property type="entry name" value="TON_0340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017135">
        <property type="entry name" value="D-Glu_cyclase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025504">
        <property type="entry name" value="GLUCM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14336">
        <property type="entry name" value="GLUCM-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037204">
        <property type="entry name" value="UCP037204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="D-glutamate cyclase-like C-terminal" evidence="10">
        <location>
            <begin position="314"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB62372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="630" mass="68722" checksum="7D81E735F3BCCBF6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPC2</accession>
    <name>A0A401NPC2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-binding motif, single-stranded-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005251">
        <property type="protein sequence ID" value="GCB62699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPC2"/>
    <dbReference type="STRING" id="75743.A0A401NPC2"/>
    <dbReference type="OMA" id="KQSWILI"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB62699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17581" checksum="19A3ACF46E0D0CB4" modified="2019-05-08" version="1" fragment="single">QAGMTLTYDPSAMQNGFYSTPYNIATNRMIAQTSLAPYIASPVSTYQVQSTSWMPHQPYLMQHAGAVMSPSMDHPMPMQPTSMISPLTQQMSHLSLSNTGTYMPAATAMQGTYIPQYTHVSTAAVPVEEPTKQVILRCAMMALPHLAEDIQGLKQSWILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NQ70</accession>
    <name>A0A401NQ70_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thyroid nuclear factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0009609</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003961">
        <property type="protein sequence ID" value="GCB63016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NQ70"/>
    <dbReference type="STRING" id="75743.A0A401NQ70"/>
    <dbReference type="OMA" id="PPYQETM"/>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000108">
        <property type="entry name" value="NK2 homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF33">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB63016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="350" mass="38070" checksum="560EDE4154292E4A" modified="2019-05-08" version="1">MSMSPKHTTPFSVSDILSPIEESYKKVGMDAAGNLGAHLTTYRQPQVSQPGMQQHPIGHNTSVPAATYHMSHGVPQLSHAAMGGYCNGNISNIGNMGELPAYQDTMRNSASATGWYGTNPDPRFTSISRFMAPSSGMNMGGMGALGSLGDVGKPMAPLQSTPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQHMQQDSNNCQQQQQQSPRRVAVPVLVKDGKPCQGGINAPTTTMQTQQQQSSNTSITVATNGTAHGPSQQANNTGQTSELGQTSGSPSSIQSHVTSLSHLNSSSSDYGTAMSCSTLLYGRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSQ7</accession>
    <name>A0A401NSQ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CIP2A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002702">
        <property type="protein sequence ID" value="GCB63874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSQ7"/>
    <dbReference type="STRING" id="75743.A0A401NSQ7"/>
    <dbReference type="OMA" id="SYKAFTH"/>
    <dbReference type="OrthoDB" id="73401at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042510">
        <property type="entry name" value="CIP2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048701">
        <property type="entry name" value="CIP2A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161:SF2">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21044">
        <property type="entry name" value="CIP2A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIP2A N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="753"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB63874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="927" mass="105009" checksum="38AEED5FA9B55C9C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT89</accession>
    <name>A0A401NT89_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bis(monoacylglycero)phosphate synthase CLN5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ceroid-lipofuscinosis neuronal protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Palmitoyl protein thioesterase CLN5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-depalmitoylase CLN5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0004544</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77599"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:72828"/>
            <dbReference type="ChEBI" id="CHEBI:232637"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77600"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(3'-acyl-sn-1'-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77619"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:64840"/>
            <dbReference type="ChEBI" id="CHEBI:232628"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77620"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-sn-glycero-3-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77607"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
            <dbReference type="ChEBI" id="CHEBI:232639"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-sn-glycero-3-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77603"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:72827"/>
            <dbReference type="ChEBI" id="CHEBI:232638"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77604"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-sn-glycero-3-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:77611"/>
            <dbReference type="ChEBI" id="CHEBI:64717"/>
            <dbReference type="ChEBI" id="CHEBI:72826"/>
            <dbReference type="ChEBI" id="CHEBI:232640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77612"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLN5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001349">
        <property type="protein sequence ID" value="GCB64113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT89"/>
    <dbReference type="STRING" id="75743.A0A401NT89"/>
    <dbReference type="OMA" id="CCCACAC"/>
    <dbReference type="OrthoDB" id="10005881at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026138">
        <property type="entry name" value="CLN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15380:SF2">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15380">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS, NEURONAL 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15014">
        <property type="entry name" value="CLN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019108139" description="Bis(monoacylglycero)phosphate synthase CLN5" evidence="15">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB64113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="342" mass="39858" checksum="53C512C0D2369CC2" modified="2019-05-08" version="1">MGISWWSVACLWLALQRAPSASAASWAATPQTWPVPYRRFDHRPEPDPFCQPVYPFCPTGSRDGEIPQMKDRDIIEVYRLQTPVWEFKYGDLLGHFHIMHDAIGFRNTLTGNNYTMEWYELFQLGNCTFPHLRPGIEAPFWCNQGAACFFEGIDDSHWKENGSLVKVSEITGAIFNKLAQWVKEDNRTGIYYETWTVQSDPSPNATVWFKSYDCSAFVLRAYQTLFELGAVFKSPTQTNYTRIFLYSGEPSYLGNDTTIFGPHSNKTRGEEITYFYFPFRPPHSVKELILSLLEIVDKVVLEKTFYLYFNFEYWYLPMKQPYIKITYEEIPLPSKQNKSKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTI0</accession>
    <name>A0A401NTI0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pleckstrin homology domain-containing family A member 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0007499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002731">
        <property type="protein sequence ID" value="GCB64191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTI0"/>
    <dbReference type="STRING" id="75743.A0A401NTI0"/>
    <dbReference type="OMA" id="ERQMEMN"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01247">
        <property type="entry name" value="PH_FAPP1_FAPP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000085">
        <property type="entry name" value="Pleckstrin homology domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB64191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="518" mass="58886" checksum="C339ABABE95B1F57" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTT6</accession>
    <name>A0A401NTT6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Miro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008035">
        <property type="protein sequence ID" value="GCB64298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTT6"/>
    <dbReference type="STRING" id="75743.A0A401NTT6"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14118" checksum="53F699D62D3479CD" modified="2019-05-08" version="1">MYDITDAKSFNYCASIYKEHYMESRIPCIFVASKADLPEQKQEHGITPVEFCYKHRLPAPFHFSCNSDEATHSQIYSRLALAAAFPDLNETELSITSFWLRITFGATIVAFLGLGIYKALARQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU39</accession>
    <name>A0A401NU39_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0007530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002747">
        <property type="protein sequence ID" value="GCB64379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU39"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB64379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="75" mass="8857" checksum="615F4CE2B20E3D86" modified="2019-05-08" version="1">MLCRLTTVCDTCFENKPIQVNTSDFVRFFLNLCCNAMARPKDYSQNLCLQFIKQTKLSKDRFLTNASHHRYKNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUB5</accession>
    <name>A0A401NUB5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Biotinidase</fullName>
            <ecNumber evidence="6">3.5.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0011755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>biocytin + H2O = biotin + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:77171"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:195545"/>
            <dbReference type="EC" id="3.5.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.12" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01005457">
        <property type="protein sequence ID" value="GCB64476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUB5"/>
    <dbReference type="STRING" id="75743.A0A401NUB5"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047708">
        <property type="term" value="F:biotinidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07567">
        <property type="entry name" value="biotinidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000001">
        <property type="entry name" value="biotinidase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012101">
        <property type="entry name" value="Biotinidase-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031699">
        <property type="entry name" value="DUF4720"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15846">
        <property type="entry name" value="DUF4720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019560007" description="Biotinidase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="37"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB64476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="439" mass="50553" checksum="C1B72D3FCD0EB4C0" modified="2019-05-08" version="1">MEAFCLRWLLLVWQCFVIPVWGLEFYKAAVYEHSTVLRQNLIPPTREEALELMQKNLDIYQEQVHEASKQGVKIIVFPENGIHGFPPTRATIYPYLEPIPDPDVVQWNPCLHPTEYSDTEVLYQLSCMARNSSMYLIANLGEREACEFSDPKCPSDGRYHFNTNVVFDAEGTLIAKYQKWKLFRTEIYYNKPKTLQHVIFDTPFAGKFGIFTCFDILFYEPAVSLIERYGIKQIIFPTAWMNKLPLLSAVQFHQAFAAAFGINLLVSNQHHPEYNMTGSGIYTPLDFPYYYNMKSREGKLLVADVPIITSINNHTLEQSDSQTSTFLQEQKGAVKQEQTDLFNLRDRMKNIQLLIICASIFLLVCVTAEPVITEGGWKSLDEQQNRDLFFRILQSYFTGRGMNLGLSRKEKLQGTYGSKIGSYADKSNNNLYNKDTFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUB9</accession>
    <name>A0A401NUB9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001374">
        <property type="protein sequence ID" value="GCB64493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUB9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="86" mass="10051" checksum="F604E366004D2D91" modified="2019-05-08" version="1">MAIMSCLAQLRGTEEVVRTLRREIEKRDKNSEGDVNEYEKENRELREQLAAKDKEMANAKRAHQSCLAHLSSFQSQYDKACQDMCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUJ5</accession>
    <name>A0A401NUJ5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006783">
        <property type="protein sequence ID" value="GCB64561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUJ5"/>
    <dbReference type="STRING" id="75743.A0A401NUJ5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB64561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8542" checksum="168DBE8069A0DDB1" modified="2019-05-08" version="1" fragment="single">SDEVEQKTTESKRKIINKLQLCLDTMSQHVTSVENYLVDYQKCAARDHEESLKDDLLTDLKFITESCKEMSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NUQ2</accession>
    <name>A0A401NUQ2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0011770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005469">
        <property type="protein sequence ID" value="GCB64574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NUQ2"/>
    <dbReference type="STRING" id="75743.A0A401NUQ2"/>
    <dbReference type="OMA" id="NEAHKAP"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB64574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="83" mass="9459" checksum="4960CD009D91B9B4" modified="2019-05-08" version="1" fragment="single">MEGHQRSEASAPSRGKEKSSKAKKSLDEGEKKTKFLERFTSMRKKEKPYVQSKHPPTPIYETQTSALNSLSDAEVLDLFEQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVH7</accession>
    <name>A0A401NVH7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein O-mannosyl-transferase 1</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0009885</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01004147">
        <property type="protein sequence ID" value="GCB64875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVH7"/>
    <dbReference type="STRING" id="75743.A0A401NVH7"/>
    <dbReference type="OMA" id="WIVESAY"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23281">
        <property type="entry name" value="beta-trefoil_MIR_POMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="237"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="311"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="373"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB64875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="441" mass="49873" checksum="476AF2F79D0AC426" modified="2019-05-08" version="1">MPIIVTVHVDVVLTILTVLGIGNRLWGLMYPNAVVFDEVYYGQFVSLYMKQMFFIDDSGPPLGHMILAVGAYYGGFDGNFSWNRIGAEYTGNVPVWNLRFLPALASALCISLAYQIVVELKYSHFSALIAALLIMFENALITQSRFMLLESVLIFFVLLAVLSYLKFYNMQRCSFSVSWWFWLFLTGTACALAIGVKYMGLFTYLLLLAIAGGHTWQIIGDTSLSNGGLARITQGQPLEIAFGSQITLRNVWSKPVPCWLHSHKNMYPIRYDSGRGSSHQQQVTCYPFKDVNNWWIVKDPGKQELVVSNPPRPVRHGDIVQLVHGMTARLLNTHDVAAPMSPHWQEISCYVDYNVSMPSQNLWKVEIVNRDANEEVWKTILSEVKLLHVNTSAVLKLSGTALPDWGYRQLEIVGDKSSNVYHQNMAWNVEEHRYGKSKAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVZ4</accession>
    <name>A0A401NVZ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proline-rich protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0014841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PROTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008125">
        <property type="protein sequence ID" value="GCB65022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVZ4"/>
    <dbReference type="STRING" id="75743.A0A401NVZ4"/>
    <dbReference type="OMA" id="RYNGRCE"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF4">
        <property type="entry name" value="PROLINE-RICH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB65022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24048" checksum="C83F633782FD6104" modified="2019-05-08" version="1">MSSPSLSDLGKSEQAALEERGTQQRRAGSNATWNSIQNAVIAVFQRKGLPENELYNLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDTVAEIWDFFFCDILPMLQAIFHPVQGKEPTVRQIALLHFRNVITLNVKLEDALSRPRARVPPSLIQMLLILQSTMVSEISNQHCAPNLLQSYLIVMINAVLKPNGAKSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW44</accession>
    <name>A0A401NW44_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein TANC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0011834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TANC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005530">
        <property type="protein sequence ID" value="GCB65103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NW44"/>
    <dbReference type="OMA" id="NCELAYS"/>
    <dbReference type="OrthoDB" id="5958958at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000022">
        <property type="entry name" value="protein TANC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000036">
        <property type="entry name" value="protein TANC2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF23">
        <property type="entry name" value="PROTEIN TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 9" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="TANC1/2-like AAA+ ATPase lid" evidence="11">
        <location>
            <begin position="633"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="12">
        <location>
            <begin position="730"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="953"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1322"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1356"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1407"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1467"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1769"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1411"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1471"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1783"/>
            <end position="1795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB65103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1810" mass="199274" checksum="B1618F959CC1B364" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWU2</accession>
    <name>A0A401NWU2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0013444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006869">
        <property type="protein sequence ID" value="GCB65341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWU2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB65341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="144" mass="16165" checksum="9D7F40C893C69369" modified="2019-05-08" version="1">MNDSDVAHPRFPNSQRFCLGSLTSECVIFTFLCAGLYIEQTSARSNQRKNIYIHLFKAALRHVSKLTPRTASQSVVKKMKGFELQFGLIVLIASLWSSGLGCHSGKEDLKCIVDYLFSMTCCWSHKVSRSAPLCEVWVDDPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWX0</accession>
    <name>A0A401NWX0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0007702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the BAR homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002838">
        <property type="protein sequence ID" value="GCB65369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWX0"/>
    <dbReference type="STRING" id="75743.A0A401NWX0"/>
    <dbReference type="OMA" id="CADHRSH"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000103">
        <property type="entry name" value="Homeobox protein BarH-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF12">
        <property type="entry name" value="BARX HOMEOBOX 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB65369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="249" mass="27755" checksum="86396DE43D4590D4" modified="2019-05-08" version="1">MMQNPLELEAHYLPHEPIHDYRSHRYRSFMIEEILTEPRGPGKATNGGELLKFGVHALLNSRPYHSHLAGLKSDHTGVFKFPLGPISCSLAAPLGSALVSGGSSLTTGPGGPHLPLDLHLRSKLEQGPELGNKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLSEQEKAKQAEKQIKNSPSPSEVNQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NY88</accession>
    <name>A0A401NY88_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001465">
        <property type="protein sequence ID" value="GCB65839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NY88"/>
    <dbReference type="STRING" id="75743.A0A401NY88"/>
    <dbReference type="OrthoDB" id="10435489at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="334" mass="37863" checksum="0942BAF397FF98F7" modified="2019-05-08" version="1">MPMHPLSSPDIQLFKVLLNNSGFFFKYKINYSRHKLVRSEDEKQDKEIFQRTMKMRLEHFKPTKLEVNHNATIRNTKKEKATIKKHSDVVPNKQTLTHSDALHKDKDSEVKNHCDPSDDGISFLITPEINESEETITGNSKSIPSPPPLPSPSTLDAKQLSMKDGQVSQDDLSSERPSRIFPSYLQKTWVQSYSSLENVESQVSTISEQVAAQEESTTEITSEATVDSPSETKLNEEDHPTRLDSEGTSVKVQCAETLNEELEDNSPKDPGVQEQKPLIIKDSKMHSAAAKRVQNRRSFHRPKPLRYPVLQKLGSLPVSCHIPPHSLEQEETQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0T1</accession>
    <name>A0A401P0T1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0005013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001521">
        <property type="protein sequence ID" value="GCB66721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0T1"/>
    <dbReference type="STRING" id="75743.A0A401P0T1"/>
    <dbReference type="OMA" id="NIMCEEM"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF37">
        <property type="entry name" value="PLEXIN-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PSI" evidence="11">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="11">
        <location>
            <begin position="206"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="11">
        <location>
            <begin position="354"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB66721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="417" mass="46647" checksum="564C814BE60F1AA6" modified="2019-05-08" version="1">MSSTWFIQIRVDGPPNGGGHYETVHVMVDGRMILRDMGFSTDQQYLYVISERQLSRVPVESCEQYETCSKCLSSGDPHCGWCVLHNMCSRKDKCERATEPYRFAANIEQCVKLNIQPNSISVSEHSVPLILKVSDVPDLSAGVVCAFGELTEVNGQAIGDKIMCISPAAKDVPPILADQDWIGVILQLKSKETGKRFASTEFKFFNCSVHQLCLSCVTSAFRCYWCKYRNLCTHDPSICSFQEGRVNASEDCPQLVPSDEILIPVGEVKPITLKARNLPQPQSGQRGYECILNVQGVTQRVPALRFNSSSVQCQNSSYHYDTMDISDLPIEFSVVWNGNFIIDNPADIKVHLYKCDALRESCGLCLKANQKFECGWCSGEGRCTLRQHCPIVSSQWLDLSSKNVKCTNPRITKVRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P129</accession>
    <name>A0A401P129_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0007945</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01002967">
        <property type="protein sequence ID" value="GCB66814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P129"/>
    <dbReference type="STRING" id="75743.A0A401P129"/>
    <dbReference type="OMA" id="KLPWQTR"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000041">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000121">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="114"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="414"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="120"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="420"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB66814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="694" mass="78210" checksum="EC070CFF54A051EA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1Y2</accession>
    <name>A0A401P1Y2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box only protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0007998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002993">
        <property type="protein sequence ID" value="GCB67131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P1Y2"/>
    <dbReference type="STRING" id="75743.A0A401P1Y2"/>
    <dbReference type="OMA" id="RSSHIGC"/>
    <dbReference type="OrthoDB" id="9991467at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22099">
        <property type="entry name" value="F-box_FBXO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF8">
        <property type="entry name" value="F-BOX ONLY PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB67131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="360" mass="42235" checksum="B474C9A5ED5294EB" modified="2019-05-08" version="1">MPFLGQDWRSPGGCWVKSEDGWKREVDDDGEDSRPRRRQGKQQQSGQLQDEIKKNEIIGEDCEVVVKKRKKDHFNNNTKTQYFYQEKWIYVHKGSTRERHGYCTLGEAFNRLDFSSAIQDMRRFNYVVKLLQLIANSQLTSLSGAAQKNYFNILEKIVRKVLEDQQNPRLIKNLLQDLGSALCILVREVGRCVLVGNINIWVYRMETILNWQHQLNNLQITRQMNNGATLSDLPLHMQNSILYRFSDGLDIVSLGQVTSTLHMLSEDRHLWKKLCQYHFAEKQFCRHLILTEKGCVDWKLMYFTLQKYCPKKEQYGDALQFCRHCSILFWKDTGHPCTANNPETCSTPVSPQHFIDLFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P256</accession>
    <name>A0A401P256_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cysteine/serine-rich nuclear protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0000691</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000142">
        <property type="protein sequence ID" value="GCB67229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P256"/>
    <dbReference type="STRING" id="75743.A0A401P256"/>
    <dbReference type="OMA" id="YYQLGGS"/>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF13">
        <property type="entry name" value="CYSTEINE_SERINE-RICH NUCLEAR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="61"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB67229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="599" mass="65844" checksum="6B8DE0AE1E9034F5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P2K4</accession>
    <name>A0A401P2K4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transformer-2 protein homolog beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Splicing factor, arginine/serine-rich 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Transformer-2 protein homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0000719</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000145">
        <property type="protein sequence ID" value="GCB67364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P2K4"/>
    <dbReference type="STRING" id="75743.A0A401P2K4"/>
    <dbReference type="OMA" id="PHERRYL"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000160">
        <property type="entry name" value="Transformer-2 protein homolog beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB67364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="294" mass="34424" checksum="1EF74DC7BD7C5395" modified="2019-05-08" version="1">MSDTEDLTDEERVNVHEEGGIKEDNQDNDYTHKRCLEKGYLGQNGRSRSRSESTAEPAKSRSQSESRSVSRTSNLSRSRTSFSRSRSKSRSRSGSRRRSEYYSRSRSHTRSYRRRHRSRSYSPVYRRRRSNSRSPVSRRRRHIGNRSNPNPNNCLGVFGLSLYTTEPELREIFSRYGPLAGINVVHDQRTGRSRGFAFVYFENVEDSKEAKERANGMELDGRRIRVDYSITKRPHTPTPGIYMGRPTTSVGSSPYNDSYSDRYDDRDDSSRKHSPSPYHRRYRSRSRSYTPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4I5</accession>
    <name>A0A401P4I5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfotransferase</fullName>
            <ecNumber evidence="15">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0005243</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01001612">
        <property type="protein sequence ID" value="GCB68033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4I5"/>
    <dbReference type="STRING" id="75743.A0A401P4I5"/>
    <dbReference type="OMA" id="FYCLVER"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000194">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF55">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="17">
        <location>
            <begin position="129"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="12">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="344"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB68033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="382" mass="43594" checksum="757C805BB5062CC4" modified="2019-05-08" version="1">MAQSTVFSDALPTKVYRKIVVMLCVLLMSLYLLYCLSDLCHTMPSPLRVSAQGKYLAADLAGWQALRRKRLLHKLQAQGGYWKGERYFRDLRLQFQPFNLNPRGGTARFLAGNPPSTLSFSGDGARKLPQAIIIGVKKGGTRALLEFVRVHPDVRAVGAEPHFFDRHYDEGLRWYRGLMPKTLDGQITMEKTPSYFVTKEAAARIYAMSKDAKLIVVVRDPVTRAISDYTQTLSKKPDIPSFESLTFKNRTTGLIDTSWSAIQIGIYAKHLENWLQYFPMHQILFVSGERLISDPAGELGKVQDFLGLKRIITDKHFYFNKTKGFPCLKKPEGSSKPHCLGKTKGRTHPNIDPEVVQRLRDFYRPFNMKFYQMTGQNFGWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6I3</accession>
    <name>A0A401P6I3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0005354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001656">
        <property type="protein sequence ID" value="GCB68727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6I3"/>
    <dbReference type="STRING" id="75743.A0A401P6I3"/>
    <dbReference type="OMA" id="HRICKCC"/>
    <dbReference type="OrthoDB" id="195679at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08521">
        <property type="entry name" value="C2A_SLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000006">
        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000018">
        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF1">
        <property type="entry name" value="SYNAPTOTAGMIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="RabBD" evidence="8">
        <location>
            <begin position="89"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="379"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="60746" checksum="7FA781745B3B8E94" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6K0</accession>
    <name>A0A401P6K0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytokine-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003130">
        <property type="protein sequence ID" value="GCB68690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6K0"/>
    <dbReference type="STRING" id="75743.A0A401P6K0"/>
    <dbReference type="OMA" id="AYPRCES"/>
    <dbReference type="OrthoDB" id="9899179at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029253">
        <property type="entry name" value="CYTL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15974">
        <property type="entry name" value="CYTOKINE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15974:SF0">
        <property type="entry name" value="CYTOKINE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15153">
        <property type="entry name" value="CYTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019403101" description="Cytokine-like protein 1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16025" checksum="36D7B01CFBB7D191" modified="2019-05-08" version="1">MGLSRKIFLFSTLLVIADSAPPTCYSAVVRLSKGITESLGRLETFSITKRCLANLPKLYINVHNSCVTIKLRDHLYALENLITPQCRELKRIEFLKVRVKRLYNMIDRLCYRDLVFFIDDCAALERPPPPPEPQDELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7E2</accession>
    <name>A0A401P7E2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">POPDC1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0008321</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the popeye family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003157">
        <property type="protein sequence ID" value="GCB69036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7E2"/>
    <dbReference type="STRING" id="75743.A0A401P7E2"/>
    <dbReference type="OMA" id="SITACEN"/>
    <dbReference type="OrthoDB" id="425611at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000166">
        <property type="entry name" value="blood vessel epicardial substance isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006916">
        <property type="entry name" value="POPDC1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055272">
        <property type="entry name" value="POPDC1-3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101:SF17">
        <property type="entry name" value="BLOOD VESSEL EPICARDIAL SUBSTANCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101">
        <property type="entry name" value="POPEYE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04831">
        <property type="entry name" value="POPDC1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="POPDC1-3" evidence="16">
        <location>
            <begin position="108"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB69036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="424" mass="49017" checksum="5E1E0AF000F003E3" modified="2019-05-08" version="1">MRARPRGPRTPRMSNPLCRLLSHCGLSLLSRAHFYSPRSEDLSKWLEADRLRKVFFRFCTMNVTPDSRWVFSFLLENATSAPSDYAFSTRMAPISNQTESCDNWKEIHHLVFHVANFCFAIGLLIPTTVKIHMILLRAMMSIGCALFIVWAALYRCALDILIWNSLFLILNMLHLVYLLYKKRPIKLDKELRVLYRRMFEPLHVPPDLFHRLTGQFCSILTLKKDQTYAAEDKTSVDDRLSVLLKGKMKVSYRGHFLHNIYPTSFIDSPEFRSTQMNKGEKFQVTIVADDNCKFLCWSRERLTFFLETESFLHEVFKYLIGKDITNKLYSLNDPTLSDKTAKKLERQPSLCSQLSMMKMRNSMASTSDTEDGMSHFLHGGSTASSIQRSPYTRTSGKMKPIEESIEDDVFEPPSPVSQLAPNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7K3</accession>
    <name>A0A401P7K3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNN-interacting serine/arginine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005960">
        <property type="protein sequence ID" value="GCB69131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7K3"/>
    <dbReference type="STRING" id="75743.A0A401P7K3"/>
    <dbReference type="OMA" id="PPPFMKG"/>
    <dbReference type="OrthoDB" id="10065820at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031937">
        <property type="entry name" value="PNISR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31518">
        <property type="entry name" value="ARGININE/SERINE-RICH PROTEIN PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15996">
        <property type="entry name" value="PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="69673" checksum="CA990208336713A2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P8X8</accession>
    <name>A0A401P8X8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0005498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001717">
        <property type="protein sequence ID" value="GCB69543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P8X8"/>
    <dbReference type="STRING" id="75743.A0A401P8X8"/>
    <dbReference type="OMA" id="YGEWDYA"/>
    <dbReference type="OrthoDB" id="45670at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF29">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21870">
        <property type="entry name" value="GP180_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019442024" evidence="7">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="8">
        <location>
            <begin position="181"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB69543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="444" mass="49666" checksum="286E1E9A99665F72" modified="2019-05-08" version="1">MALLFLLTALAGVAMLRCEGKTVSGFFSSDIARQSGGQQVAKFLFHGTNALLSCQIDNNTVAVDKDAKLHLFHEQIWLKLQEDTGRVNCLVKFSEAQLTISLDDVENNQTISQFLHPQAWYIVYADRFTCPEEDENERGTDGIAAKTIKFKLLLLNPDAANNPLDHFSAEESGLHDFYFLLVLAYFIAACIYTQPIWRSIKKGGPMHTVLKVLSIGLLLQAGAAFTNYMHLSRYSVDGIGTPLLGSLAELCDMVSQIQMLYMLMSLCMGWTLGRMGRTQGRLLQWDTTPTSTAIAIVAVITQGILLLWEQFEATDHHSYHAHQSMAALLLIALRVCLALLLASSLYQIITMERSALKRDFYISFAKGCILWFLCHPALVATSMMFAEYQREKIIIIAVTLCQSISMVILYRLFISRSLYWEVSALSSVSLPLTMSSGYRSRYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9L1</accession>
    <name>A0A401P9L1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Repulsive guidance molecule A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0001123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the repulsive guidance molecule (RGM) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000240">
        <property type="protein sequence ID" value="GCB69774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9L1"/>
    <dbReference type="STRING" id="75743.A0A401P9L1"/>
    <dbReference type="OMA" id="LCWLCLL"/>
    <dbReference type="OrthoDB" id="10013795at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Repulsive guidance molecule BMP co-receptor a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040287">
        <property type="entry name" value="RGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009496">
        <property type="entry name" value="RGM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010536">
        <property type="entry name" value="RGM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428:SF4">
        <property type="entry name" value="REPULSIVE GUIDANCE MOLECULE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428">
        <property type="entry name" value="RGM DOMAIN FAMILY MEMBER DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06534">
        <property type="entry name" value="RGM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06535">
        <property type="entry name" value="RGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Repulsive guidance molecule N-terminal" evidence="11">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule C-terminal" evidence="10">
        <location>
            <begin position="162"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB69774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49909" checksum="B747A56F19F616A7" modified="2019-05-08" version="1">MQQARASRVGELEFCGIPVRAGWMGMGRRDDPLGHRVLRILIVALCFPAVSCQCRILKCNSEYLAATSGLHVDEESVEFCIALRAYSQCTRKTARACRGDLAYHSAVHGIEDLMSQHNCSKVGPTHPPPRTQPTSLDFMVHSDAPEMCNYEKSLQQKAPHPNYTHCGLFGDPHLRTFTDDFQTCKVRGAWPLIDNDYLFVQVTNVAVVQGSSATATSKLTVIFKNFQNCVDQKVYQAETDDLPAAFIDGSRNGGEKHGANSLTVTEKAAGQYIEIQAKYIGTTIVVRQVGRYLTFAVRMPELIMRSFEDNQGLQLCLKGCPTNERMDWRLVEADGGHLPSQAAVAHPSFMRETATAKCREKLPVDDLYFRSCVFDLLTTGDLNFTLAAYYAFEDVKNLHSNKEKFHIYERTADFPPGNSAPGPPSHQALAAKHLLLIFWLWCYLTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PB30</accession>
    <name>A0A401PB30_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine 5'-monophosphate synthase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
            <ecNumber evidence="6">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">scyTo_0010760</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:11597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:10382"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer; dimerization is required for enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EC" id="4.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01004698">
        <property type="protein sequence ID" value="GCB70336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PB30"/>
    <dbReference type="STRING" id="75743.A0A401PB30"/>
    <dbReference type="OMA" id="IEGDFKH"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000092">
        <property type="entry name" value="Uridine monophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000025">
        <property type="entry name" value="Uridine monophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010382">
        <property type="entry name" value="PRK13809.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="20">
        <location>
            <begin position="257"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="18">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="18">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="18">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GCB70336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="487" mass="53442" checksum="C1090AB3DB2A5BC3" modified="2019-05-08" version="1">MESLVLELFKVRAVKFGSFVLKSGISSPVYFDLRVIVSHPILLNQVSELLWLTANNAGIKCNSVCGVPYTALPLATIICSSKKIPMLIRRKEAKDYGTKRLVEGTVNPGETCLIIEDVVTSGSSVLETAEVLRKEGLKVTDAVVLLDREQGGKARLEEEGIRLHSVCTLSRLLDILQVQGKIDSEAVESVKTFIRKNACPPVNNMINGSTKRLNHQPDGIPAKKPHQEISYGARAQLPEIHPITAQLFKIMEKKETNLCLAADVTSSKELLQLADSLGSEICVLKTHVDILNDFNPAVFKELRAIADKHEFLIFEDRKFADIGNTVKHQYEGGIYKIASWSDFVNAHVVPGPGVVKGLKEVGLPLKRGCLLIAEMSTEGSLATGEYTKAAVRLAEKHSDFVIGFISSSNISNRLDFIHMTPGVQMQTGADNLGQQYLSPEEVIHKKASDIIIVGRGILTAKDCVEAARMYKKAGWAAYLNRLLSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBE3</accession>
    <name>A0A401PBE3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="5 13">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0001280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IPK1 type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="5 13"/>
    <dbReference type="EMBL" id="BFAA01000280">
        <property type="protein sequence ID" value="GCB70440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBE3"/>
    <dbReference type="STRING" id="75743.A0A401PBE3"/>
    <dbReference type="OMA" id="HRQHCIV"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.110:FF:000001">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB70440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="494" mass="56589" checksum="E15ADBB37AD1E553" modified="2019-05-08" version="1">MEVKEVDGNEWKYHGEGNRSMVVSHVQHCQVLRFLKFPIEHAQPSQALEEAPRRLKNIVDFSKHVMKLLLGDNFVQPGEVIQLPLDFVTQLALKIQPERSGSRCNKVMDAFSGYALCLPDLTKFQTCHQIEKRPPLCIEIKPKCGFIPFSSHITKDIKRHVCRYCMHQHLKVANGKWKRISKYCPLDLFSGNKQRMYIALKSLLQEPQNNLKIFKNGELIFGCKDDQDCLMDLNELANHLKAYFFPANGVVSGPQCTRTVISELIHVITIALVSNVDTCKTGDMKRTLVSQERSHCEASHFRKEALRNGIHVVENSGLPKGCVLSRILQVQMLDMMDIDGIYPLYLRVQQHIEDFPTDRSRLHLDGPYNESFYESLSDCHSQDDETVDYAAQKIHQYRVATTAKDCSIMIALSPCPVEERPEPSTIIQTSRACFVYSVSVLDLDPKPYENIAHQYKLDGKIINFYVQSMRGKKDVTTPNFYKENEECTLFFHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBZ8</accession>
    <name>A0A401PBZ8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0005735</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus outer membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nesprin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001831">
        <property type="protein sequence ID" value="GCB70645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401PBZ8"/>
    <dbReference type="OMA" id="NARWNHL"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000073">
        <property type="entry name" value="Nesprin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000137">
        <property type="entry name" value="nesprin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000112">
        <property type="entry name" value="nesprin-1 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000177">
        <property type="entry name" value="nesprin-1 isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000233">
        <property type="entry name" value="nesprin-1 isoform X9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000115">
        <property type="entry name" value="nesprin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000126">
        <property type="entry name" value="Spectrin repeat containing, nuclear envelope 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056887">
        <property type="entry name" value="SYNE1/2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514:SF3">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514">
        <property type="entry name" value="PKA ANCHORING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25035">
        <property type="entry name" value="SYNE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01249">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="5393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="5387"/>
            <end position="5412"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="9">
        <location>
            <begin position="5415"/>
            <end position="5444"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="13">
        <location>
            <begin position="5385"/>
            <end position="5444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4861"/>
            <end position="4903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="5324"/>
            <end position="5380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="726"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2124"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2387"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2455"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2832"/>
            <end position="2859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="3206"/>
            <end position="3233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="3850"/>
            <end position="3880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="4435"/>
            <end position="4462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="5285"/>
            <end position="5312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4870"/>
            <end position="4887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="5324"/>
            <end position="5339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="5350"/>
            <end position="5360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="5369"/>
            <end position="5380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB70645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="5444" mass="625786" checksum="1AEFAA11AA1679E9" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PD63</accession>
    <name>A0A401PD63_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DALR anticodon binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003406">
        <property type="protein sequence ID" value="GCB71070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PD63"/>
    <dbReference type="STRING" id="75743.A0A401PD63"/>
    <dbReference type="OMA" id="IFVMYNC"/>
    <dbReference type="OrthoDB" id="9990834at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106217">
        <property type="term" value="P:tRNA C3-cytosine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037380">
        <property type="entry name" value="DALRD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16043:SF1">
        <property type="entry name" value="DALR ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16043">
        <property type="entry name" value="DALRD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="1">
        <location>
            <begin position="350"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="490" mass="55622" checksum="6C00E479B16B36B5" modified="2019-05-08" version="1">MVPEDLVERLLLEYRQRHYIQSCKQMDKGLVIRLDHPALFMQVLSNLPLYTRPLKAPSSKKKCVILNCAALQGNKGPESLTVSHLRTILLVDHLAVLLRQQGCEVHTTPNLCQKTSACNLLKLLRVAWPSTWPTTSNEGGVSNLKKVLSESVYAQLGKFDAPSDQAHNTLPKDVVFKVHLRQFMKEKELGGYDANLDMALVQEEALRQIAELQHIVLQEDAEEYLVIHVVGCEEQFQQQKIDLLWQILDNGDDRVTQRHLVCGSVKITGENSHLSAVQYFQFRRSQMQEASVMKYGKLVQGESWAEIINNMTSASIRFELLATAHRSPLNLDMTQAVNISTKGTKSGAFVMYNCARLATLFDHFHKSVQQGLYPKFPETSQLNFSALREEGEWLLLYNYVIPFREVLCQTTQSLSSAKGIRLTINTETICKFLVNLSIDFSSYYNRAHILGEPLDHLFNQMFARLQLMKALREVFHTALGTLHIAPPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDE2</accession>
    <name>A0A401PDE2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Insulin receptor substrate 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0001471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000332">
        <property type="protein sequence ID" value="GCB71135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDE2"/>
    <dbReference type="STRING" id="75743.A0A401PDE2"/>
    <dbReference type="OMA" id="NDCENGM"/>
    <dbReference type="OrthoDB" id="946068at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01257">
        <property type="entry name" value="PH_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01204">
        <property type="entry name" value="PTB_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000029">
        <property type="entry name" value="Insulin receptor substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000129">
        <property type="entry name" value="Insulin receptor substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039011">
        <property type="entry name" value="IRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614:SF11">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00628">
        <property type="entry name" value="INSULINRSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="6">
        <location>
            <begin position="157"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1044"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB71135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118274" checksum="A9EB336828FB5C76" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDG8</accession>
    <name>A0A401PDG8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003419">
        <property type="protein sequence ID" value="GCB71161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDG8"/>
    <dbReference type="STRING" id="75743.A0A401PDG8"/>
    <dbReference type="OMA" id="RECEYIS"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000587">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="1">
        <location>
            <begin position="98"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="1">
        <location>
            <begin position="434"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="521" mass="58616" checksum="E8BA9D552169DEC8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDL1</accession>
    <name>A0A401PDL1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004840">
        <property type="protein sequence ID" value="GCB71230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDL1"/>
    <dbReference type="STRING" id="75743.A0A401PDL1"/>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB71230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="139" mass="16200" checksum="674BD7E7B0060775" modified="2019-05-08" version="1">MEMKPLQRMESYVQDTFSEKHHSNLSSKNTMEDYHPDFLSYGVQRLKRTTQNTENFRPMPPSEPNVQRLETLRMNVKLEPRPSRHDISMSPNLKTVTVPQCEEEMMVQYKSNSGSNPILVAMVILLNISVAILFVHFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PGM9</accession>
    <name>A0A401PGM9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450 26C1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0001913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000448">
        <property type="protein sequence ID" value="GCB72287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PGM9"/>
    <dbReference type="STRING" id="75743.A0A401PGM9"/>
    <dbReference type="OMA" id="MKRRMPV"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000145">
        <property type="entry name" value="Cytochrome P450 family 26 subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF100">
        <property type="entry name" value="CYTOCHROME P450 26C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB72287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62944" checksum="D9410F957FAD15C7" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PH21</accession>
    <name>A0A401PH21_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0006279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002087">
        <property type="protein sequence ID" value="GCB72384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PH21"/>
    <dbReference type="STRING" id="75743.A0A401PH21"/>
    <dbReference type="OMA" id="VHTEGHS"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20062">
        <property type="entry name" value="FH_FOXO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000032">
        <property type="entry name" value="Forkhead box protein O4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047409">
        <property type="entry name" value="FH_FOXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032067">
        <property type="entry name" value="FOXO-TAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032068">
        <property type="entry name" value="FOXO_KIX-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16676">
        <property type="entry name" value="FOXO-TAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16675">
        <property type="entry name" value="FOXO_KIX_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="129"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="8">
        <location>
            <begin position="129"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB72384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="593" mass="64649" checksum="92C6A9F73E5F8F6C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PHZ1</accession>
    <name>A0A401PHZ1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">scyTo_0002151</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000521">
        <property type="protein sequence ID" value="GCB72731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PHZ1"/>
    <dbReference type="STRING" id="75743.A0A401PHZ1"/>
    <dbReference type="OMA" id="PACQNCP"/>
    <dbReference type="OrthoDB" id="5985572at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03580">
        <property type="entry name" value="NTR_Sfrp1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000001">
        <property type="entry name" value="secreted frizzled-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF11">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019355487" description="FZ domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="12">
        <location>
            <begin position="165"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GCB72731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32680" checksum="3938750C17F13D18" modified="2019-05-08" version="1">MPGLTRGCVLSLLCVPWFVLRTHCFDIGLSTKCVSVPKEMGLCQDVGYSEMRLPNLMGHTTFGEVIPRSAEWEPLLRTGCHSQAATFLCSLFAPVCLATFIQPCRSMCVAVRDNCRHVLACHGQSWPDAFDCDRFPADEDTCLTSINAESAAYRKFFPKPTCQGCPATEEPGAHKRVLQTFCQNNFAVKVTLARRKGATGVSEYDVQGRVEMISPGSLFPFGTRTIIQQWLLINANCAHTMIQSSNRGAQYVLIGNVRDANIIVNKIYLWHKRDTQLTLAARKWKQHKCSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PIH5</accession>
    <name>A0A401PIH5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein disulfide-isomerase TMX3</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Thioredoxin domain-containing protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Thioredoxin-related transmembrane protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">scyTo_0006548</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01002224">
        <property type="protein sequence ID" value="GCB72940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PIH5"/>
    <dbReference type="STRING" id="75743.A0A401PIH5"/>
    <dbReference type="OMA" id="AHRVSGX"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03000">
        <property type="entry name" value="PDI_a_TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000115">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000121">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019540347" description="Protein disulfide-isomerase TMX3" evidence="18">
        <location>
            <begin position="35"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="19">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="415"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GCB72940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="471" mass="52871" checksum="2AA27A4C2E7EEC4D" modified="2019-05-08" version="1" fragment="single">PLLTSKMAASGAVHLVLFLCGVAVFRSAAVSSFAIDLDSSFKDSREDDIWLVDFYAPWCGHCKKLEPIWDEVAAEMFSSGSPIKVGKMDATVYAGIASEFGVRGYPTIKLLKGDLAYNYRGPRTKEDIIEFAGRVSGPLVRSLSTQQLFDHWQKRHPVFFVYVGGESPLKEKFFEVAAELIVYTYFFSASEDALPEDVSIQELPAILVVKDGTYYTYDEYEDGDLSSWVTKERFLGYVYIDGFTLYELADTGKLVVVAVIDSTNSSEEHISLKAMTQEVATGYREQFHRNFQFGHIDGADYINSVIMDEVIVPSIVVLNTSNQQYFIPETAIGSIEDLIKFITDILEGSAQAQGGDSFYYRVRRLLYDGKSTILSVFKTSPLLGCFLFGLPLGVISIMCYGIWTADGEYEPEEGELLQNEAIEQGDAEASDEEKEENHDKHHKADNEVKEDSKELKDEELEEKSMVEKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PJ68</accession>
    <name>A0A401PJ68_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0002381</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000596">
        <property type="protein sequence ID" value="GCB73155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PJ68"/>
    <dbReference type="STRING" id="75743.A0A401PJ68"/>
    <dbReference type="OMA" id="FEREMVF"/>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000024">
        <property type="entry name" value="Potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000019">
        <property type="entry name" value="Potassium voltage-gated channel, subfamily G, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003969">
        <property type="entry name" value="K_chnl_volt-dep_Kv6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF90">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01492">
        <property type="entry name" value="KV6CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="56"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="462"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB73155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="507" mass="57908" checksum="B4CF91A1A8BD4C38" modified="2019-05-08" version="1">MALLADGRSERELKTFTCNLGSVATCTKKGIYYHKVKLLQPDEDVRCVTQLNESLRFAIINVGGIKYRISWITLDQIPLTRLGKLKSCRGYDEIMDICDDYDVTRNEFFFDRNPCAFRTIMTFLTAGKLRLLREMCALSFQEELIYWGIEDENLEWCCRRKLNQKVEELEELKRDYEVLLTEESQGAFDDTTRLGHCMKNLRDMVENPDSGIPGKIFACLSVIFVTITTVSLCISTMPDLREEEERGECSQKCYNIFVLETICVAWFSLEFLLRFIQARSKCAFLRTPLNIIDIMALLPYYISLIIDALSIDGKPTGPGHLDLEKIGLVLRVLRALRILYVMRLVRHSLGLQTLGLTVQRCTREFGLLLLFLCVAMALFSPLVFLAESELGAKHDFTSIPSSYWWAVISMTTVGYGDMVPRSIPGQVVALSSILSGILLMAFPVTSIFHTFSRSYMELKEQQQRASSSKAQRNSDSSQETDISFPTDLGDPSLQKKRRIIRRRAEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PK92</accession>
    <name>A0A401PK92_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial S-adenosylmethionine carrier protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0002601</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)</text>
            <dbReference type="Rhea" id="RHEA:75479"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000662">
        <property type="protein sequence ID" value="GCB73521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PK92"/>
    <dbReference type="STRING" id="75743.A0A401PK92"/>
    <dbReference type="OMA" id="PRINLIV"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="86"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB73521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="154" mass="16431" checksum="D6FEE674C5B305BB" modified="2019-05-08" version="1">MFPRINLIVSQAGGVAGLCADLTLFPLDTIKTRLQSPQGFYNAGGFRGIYAGVPSAALGSFPNAALFFVTYEYTKSVLGSSVSTKKAPLVHMIAASLGEVVACLVRVPSEVVKQRAQACPSLGTYKVFIDTVRHEGILGLYRGYGSTVKRERAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKD8</accession>
    <name>A0A401PKD8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0002666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000680">
        <property type="protein sequence ID" value="GCB73586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKD8"/>
    <dbReference type="STRING" id="75743.A0A401PKD8"/>
    <dbReference type="OMA" id="YSYSIYP"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000078">
        <property type="entry name" value="NK2 homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF111">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="120"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB73586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="302" mass="33718" checksum="73A58F1D28ADA561" modified="2019-05-08" version="1">MLPSPAASTTPFSVKDILNLQHRHHKQWIPDHLDLLPSPCMLEQANQPQSTLVSGLGNEVSKSHIQRNGVAFSPGLGTNGAEVCGESRLDSSLQSHSQGKKLIREAKKNDASEGLGRRVRRKPRVLFSQAQVYELERRFKQQRYLSAPERDHLASVLKLTATQVKIWFQNRRYKCKRQRQDKHLELGTAPRRVAVPVLVHDGKPCLGASPPYNAPYNVNMAPYSYSIYPSYPSYNTGTCDGDYSCMYSSMPTLPQNPPATPFANMSMNFNVGNMNYSTIPSQAHQNPGVSALQGTFHGIRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKK7</accession>
    <name>A0A401PKK7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase subunit beta</fullName>
            <ecNumber evidence="17">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">scyTo_0002730</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:57722"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="17"/>
    <dbReference type="EMBL" id="BFAA01000700">
        <property type="protein sequence ID" value="GCB73650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKK7"/>
    <dbReference type="STRING" id="75743.A0A401PKK7"/>
    <dbReference type="OMA" id="DTQSPIM"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 17" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="191"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GCB73650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="521" mass="55872" checksum="30BB7757217A43BF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PKK9</accession>
    <name>A0A401PKK9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Citramalyl-CoA lyase, mitochondrial</fullName>
            <ecNumber evidence="4">2.3.3.9</ecNumber>
            <ecNumber evidence="18">3.1.2.30</ecNumber>
            <ecNumber evidence="19">4.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">(3S)-malyl-CoA thioesterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Beta-methylmalate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Malate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">scyTo_0002754</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3S)-citramalyl-CoA = pyruvate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22612"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58668"/>
            <dbReference type="EC" id="4.1.3.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:87810"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="4"/>
    <dbReference type="EC" id="3.1.2.30" evidence="18"/>
    <dbReference type="EC" id="4.1.3.25" evidence="19"/>
    <dbReference type="EMBL" id="BFAA01000708">
        <property type="protein sequence ID" value="GCB73674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PKK9"/>
    <dbReference type="STRING" id="75743.A0A401PKK9"/>
    <dbReference type="OMA" id="WTTPWTH"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047777">
        <property type="term" value="F:(S)-citramalyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106064">
        <property type="term" value="P:regulation of cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000014">
        <property type="entry name" value="Citrate lyase subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040186">
        <property type="entry name" value="Citramalyl-CoA_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105:SF0">
        <property type="entry name" value="CITRAMALYL-COA LYASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105">
        <property type="entry name" value="CITRATE LYASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="26">
        <location>
            <begin position="35"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GCB73674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="329" mass="36455" checksum="52897BA6E7A9FACD" modified="2019-05-08" version="1">MYSGNSAKTCSTLGHVEHCRYTCSANTKHKYVPRRAVLYIPGNDERKLHKITSLRVDCAVLDCEDGVALNKKEEARLTVAKVLTRPHVSRTDLCVRINCVSSGLAELDMEVILQSEVLPPTLMLPKVETVEEIKWFANRFAKYSKGRTLKEPMNLITFVETAVGLLNFKAACEEAQCLGAHAGFRLDGVVFGSDDFCASIGATRTKDARELVYARQKVVVTAKAFGLQAIDLVYIDYKDEEGLCRQSREGALMGFTGKQVIHPSQVPIVQEAFSPNPERVKWAQELIDAFGEHQKLGKGAFTFHGSMIDMPSLKQAQNIITLASAIKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PLD5</accession>
    <name>A0A401PLD5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0003005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000786">
        <property type="protein sequence ID" value="GCB73923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PLD5"/>
    <dbReference type="STRING" id="75743.A0A401PLD5"/>
    <dbReference type="OMA" id="CSLETTW"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF289">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="63"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB73923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="998" mass="113817" checksum="15ED3D97F2FB7A01" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PM27</accession>
    <name>A0A401PM27_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0003279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000882">
        <property type="protein sequence ID" value="GCB74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PM27"/>
    <dbReference type="STRING" id="75743.A0A401PM27"/>
    <dbReference type="OMA" id="VLYNMYD"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019346130" description="Peptidase M20 dimerisation domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="224"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="489" mass="54201" checksum="70871E32987846F8" modified="2019-05-08" version="1">MLTFAIFSLLLHFAMQASPPLDQVFQYIDEHQDDYVQHLKEWIAIQSESSNPTKRDDVIRMMQVVGETIKRLGGTVELTDVGNEELPSGKIIPLPPVVLGKLGKDPNKTTVGIYGHVDVQPARFEDGWSTDPYLLTEKDGNLYGRGSSDDKGPVLAWLHAIEAFQALKQELPVNLKFIFEGMEESGSKGLDELLKAKNETFFSNIDYIVISDSAWLSKKPALTYGTRGLCYFIIEVQCANQDLHSGLYGGTVHEAMTDLIALLDSLVNSTGYVLIPGIDSDVVPLTNEERVLYKEIEFNLEAFKHTIGTTELLHKTKEDVLLHRWRFPSLSIHGIEGAFSGPGAKTVIPAKVTGKFSIRLVPNMDPDKLSNQVMTYLNGVFAARGSPNQMQVALESGSKAWVAHVTDKQYDAGRRAISKVFGVEAELIREGGTIPVARSLQHTTQKSVMMLPIGSPDDRIHSQDEKLSRDNYINGTKLFAAYIAEISQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PP76</accession>
    <name>A0A401PP76_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0020269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016135">
        <property type="protein sequence ID" value="GCB74851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PP76"/>
    <dbReference type="STRING" id="75743.A0A401PP76"/>
    <dbReference type="OMA" id="ISISRMC"/>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000007">
        <property type="entry name" value="Myosin-ib isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF291">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TH1" evidence="3">
        <location>
            <begin position="170"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB74851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="308" mass="36025" checksum="068F7E561D5DDBCD" modified="2019-05-08" version="1" fragment="single">LEDRRRTQMEVLATLIQKTYRGWRCRTHFRLMKKSQILISAWFRGHNQQKKYQQLKKATIFLQACTRGWEVRKCHRKYFKSNASKTIRNFIISSIIQKYFLSLKNTLPSMSPTDKKWPALPYLFLDKAHQELKRIFCLWKCKKYRETLSNQKKAELEEKLYASELFKDKKAAYASSVPQPFKGMYMDAQRKAKYQKLASSIEGKLLMMDTATKINRKDGKQSPRILIMTNSYFVLADPKSLQIKTLIKMNEIASISMSQRKDGLFALHVVENSSVGPKGDFLLNSDHLVELTTKLHRSILDATQQKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PPX2</accession>
    <name>A0A401PPX2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0018172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012395">
        <property type="protein sequence ID" value="GCB75101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PPX2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="342" mass="35420" checksum="97A33CA0AA309454" modified="2019-05-08" version="1">MQRRSVQQRSVQQRTVQQRSGQQRSGQQRSMQQRSMQQQSMQQRAAAERAAAEHAAADRAAAERAAAERAAAERVAAERVAAERAAAERAAAERAAAERAAAEHAAAERAAAERAAGSVQRGSVQQRSMQQGACSRVRAAGSVQQGSVQQGSVQQRSGQQRSMQQRSVQQSACSRERAAGERAAGERAAAERAAAECAAAERAAAGHAAGERAPGERAAGEHAAAERAAGSVQQGACSRVRAAGERAAAERAAAERAAAERAAAERAAGSVQQGACSRVRAAGERAAGERAAAERAAAGHAAGERAPGERAAGEHAAAERAAGSVQQRTVQQRNRIRQLPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQG6</accession>
    <name>A0A401PQG6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Neuronal acetylcholine receptor subunit beta-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">scyTo_0019754</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Pentamer of two alpha chains, and one each of the beta, delta, and gamma chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015039">
        <property type="protein sequence ID" value="GCB75362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQG6"/>
    <dbReference type="STRING" id="75743.A0A401PQG6"/>
    <dbReference type="OMA" id="AFFINPT"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000006">
        <property type="entry name" value="Cholinergic receptor nicotinic beta 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000008">
        <property type="entry name" value="Cholinergic receptor nicotinic beta 4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022272753" description="Neuronal acetylcholine receptor subunit beta-2" evidence="21">
        <location>
            <begin position="19"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="234"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GCB75362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="26">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="55233" checksum="4367000BDE38FC2A" modified="2019-05-08" version="1">MGSVLYLCLLTIATRSHCAEVEEKLMTHLLDPNRYNRLIRPAINSSELVSIVFQVSLAQLINVNEREQIMTTNVWLKQEWNDYRLRWDPEQFEGIRKLRIHATKIWLPDIVLYNNADGTYEVSLYTNAIISFNGSIYWLPPAIYKSACKIEVKHFPFDQQNCPMKFRSWTYDNSEIDLIPKTDCASMDDFTPSGEWDIVTLPGRRNTNPSDPNYVDITYNFIIRRKPLFYTINLIIPCILITSLAILAFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVASVCVLNIHHRSPSTHIMPQWVKTIFLDRLPSLLFIKRPQNNCTRQRSHKCRNSSLCSGHMSPEEKNSAFFINPTSSKVFDFNLMEASDGFSCHQDARLRTSTKYPAELQDALDGVKFIADHMKNDDEDQRVTEDWKYVAMVVDRLFLWMFIVVCVLGTVGLFLQPFCQSQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PQZ8</accession>
    <name>A0A401PQZ8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015083">
        <property type="protein sequence ID" value="GCB75548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PQZ8"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB75548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="113" mass="12404" checksum="CEDAB43E4C77C031" modified="2019-05-08" version="1">MDHLRGSIQETPDPIPKVSDQNLRQLKPTPLPQSLSLVPDVPTVKKPVSGGEDTELLDKDPLGTESEDDMGMLPPSEPAVFWLPQRLQPAEMHHAKAMLPSPVHTTGCYTFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSS9</accession>
    <name>A0A401PSS9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centriolar and ciliogenesis-associated protein HYLS1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0018311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HYLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012631">
        <property type="protein sequence ID" value="GCB76206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSS9"/>
    <dbReference type="STRING" id="75743.A0A401PSS9"/>
    <dbReference type="OMA" id="PNDYIVP"/>
    <dbReference type="OrthoDB" id="6343432at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052319">
        <property type="entry name" value="Centriolar_ciliogenesis_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026227">
        <property type="entry name" value="HYLS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027918">
        <property type="entry name" value="HYLS1_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34174:SF1">
        <property type="entry name" value="CENTRIOLAR AND CILIOGENESIS-ASSOCIATED PROTEIN HYLS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34174">
        <property type="entry name" value="HYDROLETHALUS SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15311">
        <property type="entry name" value="HYLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02098">
        <property type="entry name" value="HYLETHALUSS1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centriolar and ciliogenesis-associated protein HYLS1 C-terminal" evidence="9">
        <location>
            <begin position="308"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB76206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="409" mass="46937" checksum="867FD07ED1B5B504" modified="2019-05-08" version="1" fragment="single">SCGLCWFGDPGALSFRGRKKGRLLFFATSAMAGLDFTDQDVREQLDLLGYRNVPHHQLREFRKDLEELIIHERSKSQTSSKASDSVESRGSTKSPNYVSQVRNKSIHQPLAAPQIPTWREFNSGKENQSSNRWGIETLFHHPAEFHQCDAYTKYSIAPKQFGYSSMPTGLNLQNIPNQDSDDSQKQYENSSTSSPEAPSESNRKPILRRKVLRRKNGQLHVCDESMISETDSDAVSELGQRISRFRTLNNEAELDRESEEVSSTSDAGSIAGRRPNSAQPFFTRDLWSSRPGGTEGYGCISNAPKSFIRPLMDHPHTRNIKKSDPVAKYFEYKRNWETFKAPGEKDRKELRWGIREQMFYKNQLPLKPQHIYVPNDYIVPTEKKRSALRWQIRHELASGTIPQKFFCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PSY9</accession>
    <name>A0A401PSY9_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0016540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010045">
        <property type="protein sequence ID" value="GCB76266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PSY9"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB76266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="67" mass="7801" checksum="22EEA4435B3382BD" modified="2019-05-08" version="1">MAWPVSVSLHSLEVKQEEEKRNEMRRHSLDLAYVPYSLTALQTEKDDGEHKQTLGHKVITSLKWSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PTE9</accession>
    <name>A0A401PTE9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">scyTo_0016555</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer. Interacts with MFN1 and MFN2; functions as a guanyl-nucleotide exchange factor/GEF for MFN2 and also probably MFN1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="12"/>
    <dbReference type="EMBL" id="BFAA01010072">
        <property type="protein sequence ID" value="GCB76410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PTE9"/>
    <dbReference type="STRING" id="75743.A0A401PTE9"/>
    <dbReference type="OMA" id="WKQHTEI"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019495084" description="tRNA(His) guanylyltransferase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="16">
        <location>
            <begin position="60"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="17">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GCB76410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="322" mass="37345" checksum="ADCBDE50331FAC57" modified="2019-05-08" version="1">MSGGFLCGCLMPYLHGLLKVAATAGLSRCSRKTGGVRRGFFWDLPHVRAQSRKTMAKSKFEYVRNFEADDTCLQNCWVVVRLDGRNFHKFADQHGFKKPNDERALQLMSKCALTVMEELNDIVIAYGQSDEYSFVFKRKSNWFKRRASKFISHVVSQFSSSFVFYWQDYFKDQALLFPPGFDGRVVLYPSNQNLRDYLSWRQADCHINNLYNTTFWALVQQGGLSNSEAEEKLKGTLAGEKNDILFLEFNINYNNEPEIYRKGTVLIWHKIEETIDKRITTPDAPEGKNVVVKRTRNKLLPFHMDVIGDKFWEEHSQILADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV10</accession>
    <name>A0A401PV10_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0020521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01016686">
        <property type="protein sequence ID" value="GCB76903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV10"/>
    <dbReference type="STRING" id="75743.A0A401PV10"/>
    <dbReference type="OMA" id="HYRVTHT"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000099">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF13">
        <property type="entry name" value="TENASCIN-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB76903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="185" mass="20231" checksum="02B108277D056766" modified="2019-05-08" version="1" fragment="single">MNAGIGCEHLDRPLGLTLTASSNTSISLTWTEIRGPVDHYRVTHTTALGVSSEVKIPSGSHSVTFNNLEPHRKYNVSVVAERGWQQSYPSTIEGLTGPYSIEELTFSDINVSSVNVSWQRPTPAADIFILHYNPRNNGDTMNVTVDGTETYTILSNLKPGEEYIFTLVAIQGTITSEPVLGTFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV62</accession>
    <name>A0A401PV62_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0019215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014073">
        <property type="protein sequence ID" value="GCB76953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV62"/>
    <dbReference type="STRING" id="75743.A0A401PV62"/>
    <dbReference type="OrthoDB" id="6288856at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026636">
        <property type="entry name" value="MPHOSPH9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14926">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14926:SF1">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB76953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="223" mass="24661" checksum="2E19D0A9C512E726" modified="2019-05-08" version="1" fragment="single">CKTVKSLFYHPDEHQTLTKAPPDDVARRKWLTPGSDHSIFTGQPLESNDNAPSSEFGETPLQPRRFYSPPEKDRPCSQQDPSNDMEEPIPPILKALQKLDARNMSESWGAQTPMYDVSEAGDGTKFLNHRQTVGFADSTYGRGKSVDSHKDRTRSKGSGSPPGQRSSSVPPSNRRSTPTSTPTKRNTLLTSLSAKSSPKRCPKENLSPGFNHLLGKEEKTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PV85</accession>
    <name>A0A401PV85_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 184C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0015593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008912">
        <property type="protein sequence ID" value="GCB77050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PV85"/>
    <dbReference type="STRING" id="75743.A0A401PV85"/>
    <dbReference type="OMA" id="QWRRWIR"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB77050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="50341" checksum="FCA57F35BEC14CFE" modified="2019-05-08" version="1">MPCTCGNWRRWIRPLVVFLYIVGVLVAIPLCVWELRKSEVGTHNKAWFTAGIFVFMTIPISLWGILQHLVHYTQPELQKPIIRILWMVPIYSLDSWIALKYPHIAIYVDTCRECYEAYVIYNFMIFLLSYLTYQYPNLVILLEAKDQQKHLPPLCCCPSWHMGEVLLFRCKLGVLQYTVVRPFTTIVALICELVGVYDEGNFSFKNAWTYLVIINNLSQLFAMYCLVLFYKVLRNELNPIQPVGKFLCVKLVVFVSFWQAALIALLVKVGVISEKRTWDWESVEAVATGLQDFVICIEMFFAAIGHHYSFSYKPYVQEAEEGSCLDSFLAMWDLSDIRADISEQVRNVGRTVLGRPRKTNIVVEEEHNEHTSLLSSASQDLNSDTPSLPPSPMGYYQGFGQTHAALAPHPTLSSATNDAIDNLAKEQEVEDSLNPVPNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PVS6</accession>
    <name>A0A401PVS6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0017573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01011532">
        <property type="protein sequence ID" value="GCB77231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PVS6"/>
    <dbReference type="STRING" id="75743.A0A401PVS6"/>
    <dbReference type="OMA" id="ILREAKC"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="1">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB77231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="112" mass="13267" checksum="0DEB94DE1D96B8F3" modified="2019-05-08" version="1" fragment="single">KSSDILKSTRGMSIVRKYNKVAYVLVKFEVLYHKAWTKEISTMKYVLQATLLIRDQETEKMYSNFDHRILEILREAKCMLKMDLEVPELAKRLLKTEQMLKTNSNNLEVHCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PWY8</accession>
    <name>A0A401PWY8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0016719</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010293">
        <property type="protein sequence ID" value="GCB77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PWY8"/>
    <dbReference type="STRING" id="75743.A0A401PWY8"/>
    <dbReference type="OMA" id="LSCCKCP"/>
    <dbReference type="OrthoDB" id="9945063at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038036">
        <property type="term" value="F:sphingosine-1-phosphate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000098">
        <property type="entry name" value="Sphingosine 1-phosphate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004061">
        <property type="entry name" value="S1P_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00642">
        <property type="entry name" value="EDG1RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01523">
        <property type="entry name" value="S1PRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="55"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="275"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604061-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB77618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="376" mass="42186" checksum="2E551DEACDEBCDBE" modified="2019-05-08" version="1">MEAGGQSHVRYTSYTDKDIIKQHYNYTGKLRASPGSSLNVTSIFLIVVCCCIILENLMVLLAIWQTKKFHRAMYYFIGNLALSDLLAGAAYTVNILLSGSNTYKLTPAQWFVREGSMFVALAASVLSLLAIAIERYLTMLKMKPHSSGGSSRVFLLISGCWLLSVLLGGLPIMGWNCLQGFPNCSTVLPLYHKHYILFCTTVFSFILLAIVLLYARIYALVRSRSRRLTFRKYSVRSSRSCEKSLALLKTVMIVLSAFIACWSPLFILLLLDVACEVRGCPVLYKAQWFLALAVLNSAMNPIIYTLTSREMRRAFFRLLCCVCQRGPVRRLRQHKPALIATMEFSRSKSDNSSHQHKDECGTPETLMSSGNMNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXC5</accession>
    <name>A0A401PXC5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0017652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="6"/>
    <dbReference type="EMBL" id="BFAA01011640">
        <property type="protein sequence ID" value="GCB77760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXC5"/>
    <dbReference type="STRING" id="75743.A0A401PXC5"/>
    <dbReference type="OMA" id="VGEWGEF"/>
    <dbReference type="OrthoDB" id="437511at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000278">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF80">
        <property type="entry name" value="TRANSGLUTAMINASE 5,-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="9">
        <location>
            <begin position="274"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB77760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="691" mass="78114" checksum="1347D2BD66A2923E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PXD1</accession>
    <name>A0A401PXD1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="12">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0016746</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="12"/>
    <dbReference type="EMBL" id="BFAA01010327">
        <property type="protein sequence ID" value="GCB77807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PXD1"/>
    <dbReference type="STRING" id="75743.A0A401PXD1"/>
    <dbReference type="OMA" id="ECSHEAM"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000399">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="199"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="317"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB77807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="586" mass="67153" checksum="AD8C5F3A2938897C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZG2</accession>
    <name>A0A401PZG2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RAB24, member RAS oncogene family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0019415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01014421">
        <property type="protein sequence ID" value="GCB78470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZG2"/>
    <dbReference type="STRING" id="75743.A0A401PZG2"/>
    <dbReference type="OMA" id="RYXASFL"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB78470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16893" checksum="7259E9808D235F41" modified="2019-05-08" version="1" fragment="single">GHRMSGQRVDVKVVMLGKEFVGKTSLVERYVHNRFLNGPYQNTIGAAFVAKLIHVGEKVITLGIWDTAGSERYESMSRIYYRGARAAVVCFEIKAKLFETSSKTGQNVDELFQIVAEDYVNVTAFQVMTEGNAVNLAAKKKPTYFFGCCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PZW4</accession>
    <name>A0A401PZW4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0020131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01015806">
        <property type="protein sequence ID" value="GCB78661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PZW4"/>
    <dbReference type="STRING" id="75743.A0A401PZW4"/>
    <dbReference type="OrthoDB" id="5918597at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000181">
        <property type="entry name" value="Chymotrypsinogen A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF65">
        <property type="entry name" value="CHYMOTRYPSINOGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0222">Digestion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019266504" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB78661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="198" mass="22928" checksum="1441D2D0B1492B3A" modified="2019-05-08" version="1">MAFLWLLSCFAFIGASYGCGSPAISPVVTGYARIVNGEEAVPGSWPWQVSLQSDSGWHFCGGSLINDNWVVTAAHCGVSTADFVIVGAHDKSSKMELSQKSMSIAKLHLRSMQLHLRFMQLHLRFMQLHLRFMQRHLQSMQLHLRFMQLHLRFMQLHLRFMQPHLRFMQPHLRFMQPHLRFMQPHLRFMQLLGCDPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0K7</accession>
    <name>A0A401Q0K7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0020158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1"/>
    <dbReference type="EMBL" id="BFAA01015873">
        <property type="protein sequence ID" value="GCB78921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0K7"/>
    <dbReference type="STRING" id="75743.A0A401Q0K7"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF209">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="2">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB78921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="222" mass="25217" checksum="251A0F1659BA8373" modified="2019-05-08" version="1" fragment="single">QRLMSELSDMVIYCQSTHFHSFDQTWSRQAAHETSSFAETKAKKLIAENGPTFIIHNTLQLSKVYPLGSRIDSSNFNPQEMWNGGCQLVALNFQKPGMEMDLNKGKFRQNGHSGYILKPDFMRDRSIQFDPSRPISGSGLNRKQLTIKIITAQQLPKVNKEKKNSIVDPLVRVEIHGVPDDNATQKTTHIENNGYRHIHLLSRDSASLSPATLFVWIKIKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q0L4</accession>
    <name>A0A401Q0L4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0021243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01018476">
        <property type="protein sequence ID" value="GCB78880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q0L4"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB78880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="121" mass="13665" checksum="A2514C72ACE1386E" modified="2019-05-08" version="1">MLKGTIVIPKDNSRHLHGRKVLELADMHDKPYQLESNSDDNQTRDCSTVCATQLPLKVLQTNMCVDYTKFTHNGTNVRKNKTLFGQQQHSNGQEVVVLAVKPEPKQVLKAKEYESNITGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q3B2</accession>
    <name>A0A401Q3B2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0017960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01012091">
        <property type="protein sequence ID" value="GCB79811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q3B2"/>
    <dbReference type="STRING" id="75743.A0A401Q3B2"/>
    <dbReference type="OrthoDB" id="5837785at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035100">
        <property type="term" value="F:ecdysone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035076">
        <property type="term" value="P:ecdysone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003069">
        <property type="entry name" value="Ecdystd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF313">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01283">
        <property type="entry name" value="ECDYSTEROIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB79811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="202" mass="23621" checksum="AE7DB043ADF646BA" modified="2019-05-08" version="1" fragment="single">FQTLDHEDQIALLKGSTVEVMFLRSAQLYNQRFTQISHQFTQDADHYSTLSGCCHNQCFEEHIPAVMMEQSHLDEVSIIVPNYTLGTAEEFTAPMFDFYRSMGELNVTDTEYALLSATTILFSDRPYIKNKVHVENLQEPLLEILYKYSKIYHPESPQRFARLLGRLTQLRTLNHNHSEVLMSWKMKDQKLTPLLCEIWDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q413</accession>
    <name>A0A401Q413_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 81</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0017086</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential fertilization factor required for male fertility. Part of a conserved trimeric sperm complex with the essential fertilization factors IZUMO1 and SPACA6 which bridges sperm and oocyte membranes during fertilization by binding to IZUMO1R/JUNO on the oocyte.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010811">
        <property type="protein sequence ID" value="GCB80115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q413"/>
    <dbReference type="OMA" id="ECLTNWL"/>
    <dbReference type="OrthoDB" id="9390762at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039293">
        <property type="entry name" value="TMEM81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35670">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35670:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019396843" description="Transmembrane protein 81" evidence="12">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB80115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="266" mass="29299" checksum="D7B435713D6E0220" modified="2019-05-08" version="1">MLVPCAGIYLILASFHFLIHPASCQDVVNTLPPELENATFSGLLLLSASPCSKSCGLGWRSEFYCKIDKEARVSDCKLTNTLCLVNQECGLIAKTTTVGATLSISCLDATIKSLGASDFIFVWKIARGIVTTDKYLFKIFLLKDTETPWMIIIKAIEEKHAGTYMCQVQNTKTMQVVKRVLIGVRVIPENLVQLNYYEVLSPEQKEEMQILQGNPVTKKKRESFWEKVKALFSSANLATKVIASGLAIGGGLALVFGAIFLCMSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q513</accession>
    <name>A0A401Q513_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0017186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01010963">
        <property type="protein sequence ID" value="GCB80464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q513"/>
    <dbReference type="STRING" id="75743.A0A401Q513"/>
    <dbReference type="OMA" id="IRAVGSC"/>
    <dbReference type="OrthoDB" id="6163132at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB80464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="247" mass="28166" checksum="C4B08AF7EECE8CAB" modified="2019-05-08" version="1">MGSVLLSKEMYVLDSVLHSKEMYVLDSVLHSKEMYVLDSVLHSMEVYVLDSVLHSKEVYVLVSVLHSKEVYVLDSVLHSKEVYVLDSVLHSKEVYVLDSVLHSKEVYVLVSVLHSKEVYVLDSVLHNKEVYVLDSVLHSKEMYVMGSVLHSKEVYVLESVLHRKEMYVLDSVLHSKEMCVLDHVLHSKEVYVLDHVLHSKKVYVLDSVSHSKEMCVLDSVLHSKGVYVLDSVLHSKGVYVLDSVSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q692</accession>
    <name>A0A401Q692_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cation/H+ exchanger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0022093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01021161">
        <property type="protein sequence ID" value="GCB80888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q692"/>
    <dbReference type="STRING" id="75743.A0A401Q692"/>
    <dbReference type="OMA" id="QFRITAC"/>
    <dbReference type="OrthoDB" id="423807at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB80888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14012" checksum="3ABF16DF615A0789" modified="2019-05-08" version="1" fragment="single">IATMSVALVIRILVTFLMVHFSTFNMKEKVFIALAWIPKATVQAAIGSVALDMARIRNNKTAADYGLIVLTVAFLGILITAPIGALIIGLLGPKLLDKSKQQELDCSEDKESRSITCNHDQGVENDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6L1</accession>
    <name>A0A401Q6L1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0022444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022531">
        <property type="protein sequence ID" value="GCB81002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6L1"/>
    <dbReference type="STRING" id="75743.A0A401Q6L1"/>
    <dbReference type="OMA" id="ITIYSWH"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.540">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB81002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="58" mass="6698" checksum="996138E3075896DC" modified="2019-05-08" version="1" fragment="single">MALLLRVAGRQCLRIPLAPLLGARWAVPKTTSAKQEMDRFWEKNERLQRPVSPHIAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q6P4</accession>
    <name>A0A401Q6P4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023837">
        <property type="protein sequence ID" value="GCB81023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q6P4"/>
    <dbReference type="STRING" id="75743.A0A401Q6P4"/>
    <dbReference type="OMA" id="STRDSQQ"/>
    <dbReference type="OrthoDB" id="9949983at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34839">
        <property type="entry name" value="CS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34839:SF1">
        <property type="entry name" value="MYOSIN-9-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112534" checksum="344E30E12C930E2E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q700</accession>
    <name>A0A401Q700_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0022463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01022616">
        <property type="protein sequence ID" value="GCB81133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q700"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="43" mass="4710" checksum="7981B69FCEFE668E" modified="2019-05-08" version="1" fragment="single">THQQSAVYSTLNSDRTSTHNCSGSNETSKEVGAEANDEVYEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8N8</accession>
    <name>A0A401Q8N8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01028221">
        <property type="protein sequence ID" value="GCB81738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8N8"/>
    <dbReference type="STRING" id="75743.A0A401Q8N8"/>
    <dbReference type="OMA" id="TIGFDSC"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB81738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="107" mass="11705" checksum="F7FE9B5F71D7FD78" modified="2019-05-08" version="1" fragment="single">ADCLRPIVEIEDGLLQGKQLEVEGSPRAVFGYLGIPFAAPPVGSLRFAPPVRPESWTGIRSALSHPPMCLQRIRNRPPPFSVPASEDCLYLSVYTPAHPLYPNNSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Q8</accession>
    <name>A0A401Q8Q8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CW-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0021880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020384">
        <property type="protein sequence ID" value="GCB81758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8Q8"/>
    <dbReference type="STRING" id="75743.A0A401Q8Q8"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.100:FF:000002">
        <property type="entry name" value="Lysine-specific histone demethylase 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB81758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="89" mass="10328" checksum="B81BCAC77C35DE2D" modified="2019-05-08" version="1" fragment="single">HKDGYEKYATWKRIWTSNGKSEPSLKAFMSDQLVPYWVQCTKQDCAKWRQLTRDIQMTTASAKIYRCGMKTHTAVKSENSDPCSLSEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q8Y1</accession>
    <name>A0A401Q8Y1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0022578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01023062">
        <property type="protein sequence ID" value="GCB81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q8Y1"/>
    <dbReference type="STRING" id="75743.A0A401Q8Y1"/>
    <dbReference type="OMA" id="QEWLWWA"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF10">
        <property type="entry name" value="NIPA MAGNESIUM TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31552" checksum="7EBEE2F7974D737B" modified="2019-05-08" version="1" fragment="single">GLGEAANFAAYVFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKMGCILSILGSTVMVIHAPQEDEVDTLTEMVEKLQDPGFIVFAVCVVSSCLILIVLVAPRYGQKNVLVYILICSVIGSLSVSCVKGLGIAIKELFVGHRVLAQPVTWILLGCLIVCVSTQINYLNKALDIFNTSIVTPIYYVFFTTAVMTCSEILFKEWYHMTFDNILGTISGFVIIILGIFLLHAFKNISFTLGTLPPFLRNGEPGTVWSGAMRSQQYQALPDQTTEILIHPSEDGTMRCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401Q927</accession>
    <name>A0A401Q927_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0021904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01020453">
        <property type="protein sequence ID" value="GCB81882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401Q927"/>
    <dbReference type="STRING" id="75743.A0A401Q927"/>
    <dbReference type="OMA" id="GSHRELY"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042623">
        <property type="entry name" value="TMEM205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46916">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46916:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB81882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="154" mass="18046" checksum="3AAC50667F21F637" modified="2019-05-08" version="1" fragment="single">FVLINTISRHNFGLVQRSLFPYYFYTVLGGSFLNLSLYALYHPHELLNNDEAVQITSFFICVILSAFNAQWFGETTTEIMMEMHQIENEHNLGQEVGFGSHRELYKKLKEKDPKYQKLRQRFVKYHVLSMVCNLVCVFCNGLNLLYTATNLKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBR8</accession>
    <name>A0A401QBR8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01032486">
        <property type="protein sequence ID" value="GCB82824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBR8"/>
    <dbReference type="STRING" id="75743.A0A401QBR8"/>
    <dbReference type="OMA" id="RRFHFYK"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002764">
        <property type="term" value="P:immune response-regulating signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050412">
        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738">
        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738:SF186">
        <property type="entry name" value="OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="311" mass="34234" checksum="7F04B12AAE7926DC" modified="2019-05-08" version="1">MAALPMGPSLSLERETFLKGNSVRFRCRAYRPLRGLTFYLGKVVKRSAGPPLLSQVADLTTVLTLDNVTAADEGSYACWYQFIRDGHQYNSSISHTVGITVTDHPAKPSITQNRQSNIYLPGETARFRCLPPYPHTVTKFALLEAGEENVVREVSPNGATVVSFDVPLGMKTGYRNYTCAYTVQTAAGHYHSDVSDVLHLIVTDRVPPPQIGIKPSTALPAFQVTVTCTATCDLADSTFYLYKEGEDRPVSSTRAVGGTANFRISKMRSSNRGYYTCLQQVRLGTQLFNSTHSDRLNMTSAGEAFWGHFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QBW5</accession>
    <name>A0A401QBW5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0023610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01031258">
        <property type="protein sequence ID" value="GCB82871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QBW5"/>
    <dbReference type="STRING" id="75743.A0A401QBW5"/>
    <dbReference type="OMA" id="QASNCEL"/>
    <dbReference type="OrthoDB" id="40118at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF45">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN SHOC-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Roc" evidence="4">
        <location>
            <begin position="216"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB82871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="304" mass="34790" checksum="8ED421B266DAD773" modified="2019-05-08" version="1">MCNCVCSPEQKQTAEQNTEQVVDLSRQRLKVLPADILKKPHISQLILDRNRLKNVTDLRKLRNLKTLILSKNELLDFPSDIGALPYLEKLHLNQNKIQQIPEGILSQLSRLKQLKLNNNRLTDLPGDLACCKELEYLNLSHNLIEEIPETVATLGKLEEFYVDNNKLCKLPCVLFDGGCLRKFTARANPLREPPDEVCAGGLQQIRSYFKQLQTNESFEDKRVKTMFLGASMAGKSTLCKSLAKRELVTIAEHDRTIGIEINEFQTDDFSFLCWDFAGQLEYYLTHHVFITPQALVILVIDLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QC50</accession>
    <name>A0A401QC50_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0023705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01032726">
        <property type="protein sequence ID" value="GCB82960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QC50"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB82960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="138" mass="15419" checksum="A3FEB81A372AD841" modified="2019-05-08" version="1">MGGIASEGSGLQGTSKTREVLLLEKNRSVQSKNATLQIANSDLSDPVAALDPGQPLQLIVQRMQDIENENQKPRDTLEEYNKEFAEVKNQEATIKALKETTNEYEQTLSSKAESLALGKEQKLRNDSRKRTESCKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF39</accession>
    <name>A0A401QF39_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0024726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01054283">
        <property type="protein sequence ID" value="GCB84038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF39"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="177" mass="21620" checksum="6C435A110B5624C9" modified="2019-05-08" version="1" fragment="single">MKECERERNETREAEIGRNETKEGERERNERKEGEKVRSEIKEGERERNEMKEGERAKRDEVGAKQDEGGVKESETRRRRVKEGETRRRLVKETEMKEDERDRNEMKVGERERNKTKEGKRERNERKEGEREINETKECQRERYKMKEGQRERNERKEGEKVRSESKEGESERNEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QF42</accession>
    <name>A0A401QF42_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0024569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01050099">
        <property type="protein sequence ID" value="GCB83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QF42"/>
    <dbReference type="STRING" id="75743.A0A401QF42"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="133" mass="14620" checksum="A4F2F780BE04FA15" modified="2019-05-08" version="1" fragment="single">VSLLIRRDLTERAKDFNIILDDVAITELSFSKEYTAAVESKQVAQQEAQRAQFMVEKAKQEQRQKIVQAEGEAAAASMISFGRKPQSPLGGSAQLTVRTVVVPHPAPKRYSNPPLETCFSLSLTHLPTLGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QGG2</accession>
    <name>A0A401QGG2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01077794">
        <property type="protein sequence ID" value="GCB84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QGG2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="57" mass="6620" checksum="457FB871E63C7257" modified="2019-05-08" version="1" fragment="single">MEGEREMEGEREMEGEGEMEGEGEMEGEGEMEGEREMEGEREMEGERVMEGEPDMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QHY2</accession>
    <name>A0A401QHY2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein heavy chain linker domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0025615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01111640">
        <property type="protein sequence ID" value="GCB84970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QHY2"/>
    <dbReference type="STRING" id="75743.A0A401QHY2"/>
    <dbReference type="OMA" id="TNKMEAA"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF32">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="13">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB84970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="99" mass="11440" checksum="559E1CA5387220AE" modified="2019-05-08" version="1" fragment="single">MNAKLEEIEKSLDMYLETKRQIFPRFYFLSNDDLLEILGQSRNPPAVQPHMKKCFDNIKTLKMQKIGMTNKMEAAGMFAADGEYVEFKHPTLLEGPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QI55</accession>
    <name>A0A401QI55_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0025745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01122410">
        <property type="protein sequence ID" value="GCB85040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QI55"/>
    <dbReference type="STRING" id="75743.A0A401QI55"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB85040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="40" mass="4442" checksum="37FA82A0768CDF86" modified="2019-05-08" version="1" fragment="single">DVVRLVESSKTDNRDKPLKDVVIADCGKIVVEKPYAIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QIA8</accession>
    <name>A0A401QIA8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0025753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01123051">
        <property type="protein sequence ID" value="GCB85082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QIA8"/>
    <dbReference type="STRING" id="75743.A0A401QIA8"/>
    <dbReference type="OMA" id="SKINWNW"/>
    <dbReference type="OrthoDB" id="10258440at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB85082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15323" checksum="0509DD44EC7E721A" modified="2019-05-08" version="1">MKMSLAQRVLLTWLFTLLFLIILVLKLDQTLGWNWFLVFIPLWIFDTVLLVMLVVRLAGRCKAGYDRHSSNVRRKVWYLCAMLLKLGFLLALCARLERYTAMKLSWVLIPLWILLLGVLGDVGYSTFSGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLF2</accession>
    <name>A0A401QLF2_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0026919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01258061">
        <property type="protein sequence ID" value="GCB86205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLF2"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB86205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="201" mass="22420" checksum="B46D57D115939BCC" modified="2019-05-08" version="1">MDRKNGQDIDPHLMEITQPESYLQQEQLSPFNTKPQSPNYRDQQLVSNDSSTPDGNINRIEPLHTPLINEQNIGARILRTPTSSSQITHLKPPAVSSEPIVPSSDDEDADKIDPIIHCTTLTPEIKHICLGSRMWAIENSKRETVTVPVPAKSEPETMKACTLEKDAYEVTEKKIETDCSLETGTMTKKTLDLTFAALHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QLW7</accession>
    <name>A0A401QLW7_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01272352">
        <property type="protein sequence ID" value="GCB86370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QLW7"/>
    <dbReference type="STRING" id="75743.A0A401QLW7"/>
    <dbReference type="OMA" id="EDQIGIK"/>
    <dbReference type="OrthoDB" id="8960535at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB86370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="162" mass="17322" checksum="AD413C48776D8C46" modified="2019-05-08" version="1" fragment="single">QSGIEDQTGIEIQFGIEYQIGIEDQSGIEDQIGIKIQSGIEDQTGIEDQSGIEDQPAIEDQIGIKVQTGIEIQSGIEVQIGIEIQSGIEIQSGIEDHIGIGIQSGIEDQIGIEIQSGVEIQSGIEDLIEVEIQSGIEIQSGIEDQIGIEIQSGIENQIGVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QM15</accession>
    <name>A0A401QM15_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0027096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01283028">
        <property type="protein sequence ID" value="GCB86410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QM15"/>
    <dbReference type="STRING" id="75743.A0A401QM15"/>
    <dbReference type="OMA" id="CQAEHET"/>
    <dbReference type="OrthoDB" id="9049585at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000283">
        <property type="entry name" value="Immunoglobulin kappa constant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB86410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="103" mass="11097" checksum="B511A1AF89F090B1" modified="2019-05-08" version="1" fragment="single">KAPKPPAIRLFPPNATELETGRAVIVCLLTGFFPEVIRVSWKIPGESIGDVFTGSVKEDPNGAYSVISRLEVTQVQWTTKDITCQAEHETGPASATINSKTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QNR1</accession>
    <name>A0A401QNR1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01380954">
        <property type="protein sequence ID" value="GCB87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QNR1"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="72" mass="8020" checksum="8129B4E38AA0CA1F" modified="2019-05-08" version="1" fragment="single">SCLIPGTELDDAVLLSHSQTELDDAALLYHSRTELDDAVLLSHSRTELDDAALLYHFRTELDDAVLLSHSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QP77</accession>
    <name>A0A401QP77_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0027829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01412799">
        <property type="protein sequence ID" value="GCB87128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QP77"/>
    <dbReference type="OMA" id="EKPPWEM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB87128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="193" mass="21404" checksum="1688D2C00F0C2DFA" modified="2019-05-08" version="1" fragment="single">KLIAIQSSAKLIAIERSAKLIAVERSAKIIAIERSAKHISVERSAKLTAIERGAKLIAIERSAKLIAIERSAKLITIERSARLITIDRSAKLIAIQRWVKLFTIERWAKLIANERNAKLNAIERSAKLIAIQRSAKLIPIERSAKLIAIERRAQIITIESGAKLNAFERGPNLIAIERSAKLIAIERSAKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401QP96</accession>
    <name>A0A401QP96_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0027809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01409343">
        <property type="protein sequence ID" value="GCB87148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401QP96"/>
    <dbReference type="OMA" id="MSNESMM"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB87148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="171" mass="19116" checksum="175DB8EEA240A222" modified="2019-05-08" version="1" fragment="single">MSNYSEMSNDSEISNDSEMSNESMMSTDNEMSNNSEMSNYSEMSNDSEMSNDGEMSNYSEMSNDSEISIYSKMSNDGEMPNDSEMSNDSEMSNDSEMSTDSEMSNNSERDFNDSEMSNDSEMSNDSEMSNDSEMSNESEMSNDSEMSNDSELSNDSEMSNDSELSNDSEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NFM8</accession>
    <name>A0A401NFM8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calsyntenin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">scyTo_0012587</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calsyntenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006110">
        <property type="protein sequence ID" value="GCB59773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NFM8"/>
    <dbReference type="STRING" id="75743.A0A401NFM8"/>
    <dbReference type="OMA" id="CWQGSDN"/>
    <dbReference type="OrthoDB" id="10012272at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000036">
        <property type="entry name" value="Calsyntenin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000025">
        <property type="entry name" value="Calsyntenin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000062">
        <property type="entry name" value="Calsyntenin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045588">
        <property type="entry name" value="CLSTN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139">
        <property type="entry name" value="CALSYNTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139:SF4">
        <property type="entry name" value="CALSYNTENIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19699">
        <property type="entry name" value="CLSTN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="24">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="759"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="768"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GCB59773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="823" mass="93201" checksum="4CD1A14CFF88B740" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGC4</accession>
    <name>A0A401NGC4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NGFI-A-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">scyTo_0011040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homomultimers may associate with EGR1 bound to DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004896">
        <property type="protein sequence ID" value="GCB59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGC4"/>
    <dbReference type="STRING" id="75743.A0A401NGC4"/>
    <dbReference type="OMA" id="QIMQQMV"/>
    <dbReference type="OrthoDB" id="10028556at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.2010:FF:000001">
        <property type="entry name" value="NGFI-A-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006986">
        <property type="entry name" value="Nab1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039040">
        <property type="entry name" value="NAB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006988">
        <property type="entry name" value="Nab_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623">
        <property type="entry name" value="NGFI-A BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623:SF9">
        <property type="entry name" value="NGFI-A-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04902">
        <property type="entry name" value="Nab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04904">
        <property type="entry name" value="SAM_NCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nab N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="NAB co-repressor" evidence="11">
        <location>
            <begin position="191"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Nab1 C-terminal" evidence="9">
        <location>
            <begin position="323"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GCB59992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58230" checksum="B0F7F54809F7E391" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NGW9</accession>
    <name>A0A401NGW9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="15">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0011045</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="15"/>
    <dbReference type="EMBL" id="BFAA01004901">
        <property type="protein sequence ID" value="GCB60014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NGW9"/>
    <dbReference type="STRING" id="75743.A0A401NGW9"/>
    <dbReference type="OMA" id="GLRINGM"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000020">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="16">
        <location>
            <begin position="68"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB60014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="391" mass="43878" checksum="34318441F4AAE8AF" modified="2019-05-08" version="1">MTKMLRLLGNLIRRENSPAKVLVGSRNYADFASEASFDIKKCDLHRLEEGPATSTILTREDGLKYYHTMQLIRRMELKADQLYKQKIIRGFCHLYDGQEACCVGIEVAIKPTDHLITAYRSHGYSYTRGVSVKKILAELTGRRGGCAKGRGGSMHMYGNNFYGGNGIVGAQVPLGAGIALACKYFEKDELCVSLYGDGAANQGQIFETYNMAMLWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDYIPGLRVDGMDILCVREATKFAADHCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPITMLKERMLNNNLSNVEELKEIDANVRQEVEEGAQFATTDPEPPLEELAHNIYCNDAAFDVRGTNPWIKYKSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHI2</accession>
    <name>A0A401NHI2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0014145</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01007485">
        <property type="protein sequence ID" value="GCB60317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHI2"/>
    <dbReference type="STRING" id="75743.A0A401NHI2"/>
    <dbReference type="OMA" id="LPSMTWQ"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000037">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF20">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOUSLED-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="358"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB60317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="666" mass="76465" checksum="2F6BDB304C1624B4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NHT4</accession>
    <name>A0A401NHT4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0014166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007503">
        <property type="protein sequence ID" value="GCB60417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NHT4"/>
    <dbReference type="STRING" id="75743.A0A401NHT4"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB60417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18485" checksum="B2FD4484F4082F89" modified="2019-05-08" version="1" fragment="single">MMIAHKVGIPLLVTGGIGGVHHDGQNTLDISTDLTELGRNPVTVISAGVKSILDIGRTLEYLETHGVCVATFGKSRDFPAFFLPKSGFQSAYNVTDEEEAAQLIVNAHKFGQDSSVLIAVPIPEEQAASGLVIDDAIQQAVQEARNKGIRGKDVTPFILDRVYELTKGISLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NIS9</accession>
    <name>A0A401NIS9_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0003997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001141">
        <property type="protein sequence ID" value="GCB60776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NIS9"/>
    <dbReference type="STRING" id="75743.A0A401NIS9"/>
    <dbReference type="OMA" id="WWEANEE"/>
    <dbReference type="OrthoDB" id="2412973at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10337">
        <property type="entry name" value="SH2_BCAR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000007">
        <property type="entry name" value="SH2 domain containing 3C (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000013">
        <property type="entry name" value="SH2 domain-containing protein 3C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051853">
        <property type="entry name" value="SH2-Ras-GEF_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044102">
        <property type="entry name" value="SH2_SHEP1/BCAR3/NSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247:SF11">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="426"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB60776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="78597" checksum="C42D49528B587EEE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJ25</accession>
    <name>A0A401NJ25_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0014240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007572">
        <property type="protein sequence ID" value="GCB60865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJ25"/>
    <dbReference type="STRING" id="75743.A0A401NJ25"/>
    <dbReference type="OMA" id="MATHPES"/>
    <dbReference type="OrthoDB" id="8694217at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05768">
        <property type="entry name" value="IgC1_CH3_IgAGD_CH4_IgAEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000463">
        <property type="entry name" value="Immunoglobulin heavy constant gamma 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="113"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="317"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB60865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="464" mass="51009" checksum="D60732767765CC54" modified="2019-05-08" version="1">MVTVTSATPSPPTLYALLSSCEETNIAGSVTYGCLAMDYSPEISSVSWKKDQETITTGLRTYPSVLNKRGTHTLSSQLTISESEMGSSTIYCEVQRGDAVWKKEMPDRVVHHPTILLTLSPSEEITSRRFATIVCSILDFSPNSIAVKWLKDGQAFNSGIVTSPAFEVNGNYSATSRLTVPAGEWFSNTVYTCQVIHKDATQSRNITRPQGSCSSTDPVITILPPPVEQVLLEATVTLTCIVTNARYGVNLSWSQGEKTLQSEIAVKPPDSVFSQLNISTQDWLSGTRFYCVVTDQDLPTPLKKSIRKEEVTNPQEPSVTVLLPSSEASTQTFISLSCLVRGFFPREIFVKWTVNGKQLNPGNYKNTEVTAENGKNSYFLYSLLSIAAEEWASGASYSCVVGHEAIPLKITNRTVDKSSDSTDGIWTEDYEDDNGNIWTTASTFITLFFLSIFYSTAVTLVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NJW2</accession>
    <name>A0A401NJW2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 4 L6 family member 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0014289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the L6 tetraspanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007612">
        <property type="protein sequence ID" value="GCB61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NJW2"/>
    <dbReference type="STRING" id="75743.A0A401NJW2"/>
    <dbReference type="OMA" id="LEGPLMC"/>
    <dbReference type="OrthoDB" id="9937421at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008661">
        <property type="entry name" value="L6_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14198">
        <property type="entry name" value="TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14198:SF17">
        <property type="entry name" value="TRANSMEMBRANE 4 L6 FAMILY MEMBER 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05805">
        <property type="entry name" value="L6_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB61155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20179" checksum="D38684904196D795" modified="2019-05-08" version="1">MPCFTLFNGSCLLALTILAIVLNMIPLIVNCQDGRLFQSSISCYEWWLPGVFGGGILVIPTVSMSLAARKGQKCNTRTGLLLSALFGLVSVLGALYCALVSLHSLIKGPLVCNTESHSLENCSFSIEDIKSLSKVNIDLKWFMEANCGINQTGSHIVPFVPTDPTVLTREESRVPTRLSLCVKDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKF5</accession>
    <name>A0A401NKF5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0007039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002475">
        <property type="protein sequence ID" value="GCB61354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKF5"/>
    <dbReference type="STRING" id="75743.A0A401NKF5"/>
    <dbReference type="OMA" id="THIEGVC"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.350.10:FF:000002">
        <property type="entry name" value="Oxidation resistance protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF69">
        <property type="entry name" value="OXIDATION RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="8">
        <location>
            <begin position="686"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB61354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="847" mass="94941" checksum="53D756A096B4B3ED" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NKL5</accession>
    <name>A0A401NKL5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">A20-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">scyTo_0012908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006389">
        <property type="protein sequence ID" value="GCB61397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NKL5"/>
    <dbReference type="STRING" id="75743.A0A401NKL5"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4770:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GCB61397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="148" mass="16349" checksum="6DACAC21A3F14086" modified="2019-05-08" version="1">MRGTAAVCDVRGRLSGAALSRIKQVCWRNMAQETNQTQVPMLCTTGCGFYGNPRTNGMCSVCYKDFLQRQNNNGRISPASPNLSSLTEIYPVQCTEENLPEIPSSFSSSSTSGQSSPQPIMGRGKRGRKQREKKGRSIKKEGRKGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NL50</accession>
    <name>A0A401NL50_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="14">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0004122</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in galactose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="14"/>
    <dbReference type="EMBL" id="BFAA01001191">
        <property type="protein sequence ID" value="GCB61577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NL50"/>
    <dbReference type="STRING" id="75743.A0A401NL50"/>
    <dbReference type="OMA" id="MIASHRQ"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 14" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="15">
        <location>
            <begin position="11"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="16">
        <location>
            <begin position="197"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="326"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="331"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB61577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="367" mass="42930" checksum="2416411611EEA4BD" modified="2019-05-08" version="1">MEPQVTSKEIFEPSEHQHIRYNPLRDEWILVSAHRMKRPWKGQVEKPTEVNIARHDPTNPLCPGATRANGEVNSEYESTYVFDNDFPSLQPDAPDPGYRRCELLEAQFRPGIAIIILCKVMCFHPHSDITLPLMSIPEIRAVIDKWAELMVELGSKYQWVQIFENKGAMMGCSNPHPHCQVWASTFLPNEPRLADQTQRDHYNSHRVPMLLEYAKLESQKKERIVVENEDWLVVVPYWAMWPFQTLLLPRRHILRLQDLSDKERDSLASIMKRLLTKYDNLFEVSFPYSMGWHGAPTGQSILDDNSHWQLHAHYYPPLLRSATIRKFMVGYELLAQAQRDLTAEQAAERLRNLPEVHYKLKQNQQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NL81</accession>
    <name>A0A401NL81_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0007078</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Early endosome membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01002498">
        <property type="protein sequence ID" value="GCB61607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NL81"/>
    <dbReference type="STRING" id="75743.A0A401NL81"/>
    <dbReference type="OMA" id="GGPNKTC"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000180">
        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB61607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="216" mass="23524" checksum="EC4A9B17A27E4BCB" modified="2019-05-08" version="1">MTSRGGGARSNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLANKRAVEFQEAQAYAEDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNAGGTSGRTRGVDLQETSPQSRSQCCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NLK8</accession>
    <name>A0A401NLK8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_0011374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01005135">
        <property type="protein sequence ID" value="GCB61765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NLK8"/>
    <dbReference type="STRING" id="75743.A0A401NLK8"/>
    <dbReference type="OMA" id="NEDYECE"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000026">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000770">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="168"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB61765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="250" mass="28138" checksum="72511780F0D6F2BC" modified="2019-05-08" version="1">MAADIGELLVPYMPTIRVPRSGDRVYKSECAFSFDSPESEGGLYVCMSTFLGFGREHVERHYRKTGQCVYMHLKRTIKEKATGASGGGIPKKKSPRIVLELEKNENINNEDYECEDEAKLVIFPDHYEIPLPNIEELPALVTIACDAALAARSPYRRQDSDSWEEELKDSKHENNLQQLDNGVRIPPSGWRCAWCDLRENLWLNLTDGSILCGKWFFDGSGGNGHALEHYRETRYPLAVKLGTITPDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NMP5</accession>
    <name>A0A401NMP5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0014446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007756">
        <property type="protein sequence ID" value="GCB62146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NMP5"/>
    <dbReference type="STRING" id="75743.A0A401NMP5"/>
    <dbReference type="OMA" id="ENELHAD"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="414"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB62146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="591" mass="64385" checksum="2E7BD503510E87FD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NN02</accession>
    <name>A0A401NN02_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Cadherin EGF LAG seven-pass G-type receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">scyTo_0014462</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor that may have an important role in cell/cell signaling during nervous system formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007771">
        <property type="protein sequence ID" value="GCB62232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401NN02"/>
    <dbReference type="OMA" id="CQNWAEC"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000011">
        <property type="entry name" value="cadherin EGF LAG seven-pass G-type receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000059">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000123">
        <property type="entry name" value="cadherin EGF LAG seven-pass G-type receptor 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000183">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000005">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000113">
        <property type="entry name" value="Cadherin, EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000003">
        <property type="entry name" value="Putative cadherin EGF LAG seven-pass G-type receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008077">
        <property type="entry name" value="GPCR_2_brain_angio_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01694">
        <property type="entry name" value="BAIPRECURSOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="905"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="972"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1012"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1081"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="21">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="21">
        <location>
            <begin position="99"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="319"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="413"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="25">
        <location>
            <begin position="445"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="24">
        <location>
            <begin position="675"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="26">
        <location>
            <begin position="868"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="701"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1176"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1281"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1202"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1283"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1307"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1326"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GCB62232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="29">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1347" mass="150887" checksum="B029192E442CA913" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NNY2</accession>
    <name>A0A401NNY2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">scyTo_0011487</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family. USP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="BFAA01005236">
        <property type="protein sequence ID" value="GCB62566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NNY2"/>
    <dbReference type="STRING" id="75743.A0A401NNY2"/>
    <dbReference type="OMA" id="ACHNINE"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000015">
        <property type="entry name" value="Ubiquitin specific peptidase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="427"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="563"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GCB62566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="810" mass="89330" checksum="0C95760AFDD2DC34" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NPZ4</accession>
    <name>A0A401NPZ4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0014564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007859">
        <property type="protein sequence ID" value="GCB62953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NPZ4"/>
    <dbReference type="STRING" id="75743.A0A401NPZ4"/>
    <dbReference type="OMA" id="FEITEAQ"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="113"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB62953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="291" mass="32872" checksum="5F42E33DA81F7E55" modified="2019-05-08" version="1">MVKKWPIGKQGLLYDRNWMIVNQNGVCLSQKQEPRLCLIHPHIDLDQGIMTIIAEGMDPIIMSLEEEDGKQFPLQFCQTKVCGDRVKGLDCGENVARWISAFLGRRSFLIRQCSSFHRALKKQHMQVQNQALIQSPSLSLVNEAQYLLINKASILHLKEQILQRDGTCDSNSAEALTIEELIHRFRANLVVSTMRPYEEDDWAVIDIGGVSFQIVGLCSRCQMICINQENGKRSTEPLQTLYSSKDRKMTFGAYLLHQPPATSGHCAILAVGSQAYVRKREKRTTIPSAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NRG0</accession>
    <name>A0A401NRG0_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor Jun</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Proto-oncogene c-Jun</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcription factor AP-1 subunit Jun</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0004406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001311">
        <property type="protein sequence ID" value="GCB63404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NRG0"/>
    <dbReference type="STRING" id="75743.A0A401NRG0"/>
    <dbReference type="OMA" id="LNGCQRQ"/>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000012">
        <property type="entry name" value="Putative transcription factor AP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005643">
        <property type="entry name" value="JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR JUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03957">
        <property type="entry name" value="Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="239"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="244"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB63404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="318" mass="35545" checksum="1E8373BF7D2470DF" modified="2019-05-08" version="1">MSTKMEQPFYHDDALNAAFAQPENSGYGYSPKMLKQNMTLNLSDPASNLKPHLRNKNSEGILTSPDVGLLKLASPELERLIIQSSNGLITTTPTPTQFLCPRNVTDEQEGFAEGFVKALEELHKQNILPSVTCSTPSVNTAIAVSASLPSASTVYNSNLHQEPPVYANLNNFNPNSLTPQPNYNANNMNYTATQHHPMNHQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEDKVKTLKAQNSELASTANLLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NSZ7</accession>
    <name>A0A401NSZ7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane 4 superfamily member 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">scyTo_0004516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001341">
        <property type="protein sequence ID" value="GCB63977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NSZ7"/>
    <dbReference type="STRING" id="75743.A0A401NSZ7"/>
    <dbReference type="OMA" id="FVETATM"/>
    <dbReference type="OrthoDB" id="8655982at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000010">
        <property type="entry name" value="transmembrane protein 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GCB63977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="179" mass="19824" checksum="B02F185E422FBC72" modified="2019-05-08" version="1">MSTAEESRVAAVTPLKLTGLVCVVLSLCLDVVALLSPAWVTADSHFSLSLWQRCFRPGSVPDSEWNCNWALGSDWEIATVVLLLSGAVIILIAFLVALISICQGTRRRFYRPVAVLLFAAVVLQVCGLILYPIKFVETATMRTYHEFNWGYGIAWGATIFSFGGAVLYCLNPKNYDDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NT96</accession>
    <name>A0A401NT96_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0014723</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01008011">
        <property type="protein sequence ID" value="GCB64108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NT96"/>
    <dbReference type="STRING" id="75743.A0A401NT96"/>
    <dbReference type="OMA" id="ISCDKNL"/>
    <dbReference type="OrthoDB" id="5966837at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF0">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="15">
        <location>
            <begin position="248"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="445"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="116"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB64108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="489" mass="55846" checksum="A8CD2EFA2642401F" modified="2019-05-08" version="1">MADTLRRLVNTTTYKLLQNKLETWYKDYHVNSCDQNLNRCCELIELTSKVQGELFTILSLAASEGGVYSGVDTIKSRFLPWLGSSFTVITSGVTSDTSFTLMQESAEKDQKLRELTTVHEKEMVELETELNTARRQLGTIKQELAEAHMELDDTQNKSAATFLATEDEIIQLRAELRAIREQVRFYKQKVDLLDDYERQIRQLKDEVSFLSAEKSMLQERISGRRSPISFSSLTSHSPTSTKLVSASRHARLVSRFKDLYANERLNAQNLLRRYVDDLEMVQKIIFIATTEAFQAAKMAFRQFKLRVRKTLSPSHLGPESLDETVMDYIIRNLDLYDVQSSINDVIRSMSVNPKISFPPEVDFILISSFIRDVCRLAFAMQTLEPPLDVAFTTDGELFNEKKYRRSYDSDFTAPLVVYHIWPALMENDMVIAKGEAFTKRGALWSPSKSRSRSSSPIRSRSTSPTRALANDGSREHTQLYHSAGDCSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NTX3</accession>
    <name>A0A401NTX3_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">scyTo_0000263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000049">
        <property type="protein sequence ID" value="GCB64341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NTX3"/>
    <dbReference type="STRING" id="75743.A0A401NTX3"/>
    <dbReference type="OMA" id="KLEDSIC"/>
    <dbReference type="OrthoDB" id="426657at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF31">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GCB64341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26952" checksum="E8AEB3C7A0B35BBB" modified="2019-05-08" version="1">MAGYIKPVDSYKDEITCSICLQTFSYPITLTCNHSFCLRCIQDHLKHKSPEEHYICPECHVEFAEKPRLLKNAKLAERVEKLSTCQERKTVCDYCFEEDVPAAMSCVQCETFFCVTHLRPHSEKPLLKDHVLVDPTEARTLRKCEEHKETLKLYCKQDHSSICSLCSIIGKHKNHSILTIEEAKSEIQLSFTEKMKELTVKRTKTEEAVKRLRELNSHVLHQLPDKQAEAGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NU49</accession>
    <name>A0A401NU49_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0011743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005451">
        <property type="protein sequence ID" value="GCB64416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NU49"/>
    <dbReference type="STRING" id="75743.A0A401NU49"/>
    <dbReference type="OMA" id="VYYDEEC"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019543353" description="Cathepsin L" evidence="7">
        <location>
            <begin position="17"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="116"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB64416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38188" checksum="3EE408830D11DBD7" modified="2019-05-08" version="1">MKTCCVISLCLVGVFAAPGLDPELDEPWKQWKSWHHKGYVQKEEGWRRMVWEKNLRKIELHNLEHSLGRHSFKMGMNHFGDKTNEEFRQLMNGYKLKRTVKKAQGSFFLEPNFLEVPRKVDWREHGYVTTVKDQGQCGSCWAFSTTGALEGQHFRKTGKLISLSEQNLVDCSKPEGNEGCNGGLMDQAFQYVRDNGGIDSEESYPYLGTDDHPCHYDPIYNAANDTGFVDIPSGKERAMMKAVAAVGPVSVAIDASHQTFQFYESGIYYEADCSSTDLDHGVLVVGYGFEKEDVDGKKYWIVKNSWSDQWGDQGYVMMARDRHNNCGIATASSYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NVD1</accession>
    <name>A0A401NVD1_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0000335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000063">
        <property type="protein sequence ID" value="GCB64846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NVD1"/>
    <dbReference type="STRING" id="75743.A0A401NVD1"/>
    <dbReference type="OMA" id="QNAYAFI"/>
    <dbReference type="OrthoDB" id="6350321at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18453">
        <property type="entry name" value="BACK_KLHL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18243">
        <property type="entry name" value="BTB_POZ_KLHL14_printor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000381">
        <property type="entry name" value="Kelch like family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047027">
        <property type="entry name" value="KLHL14_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030584">
        <property type="entry name" value="KLHL14_BTB_POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF6">
        <property type="entry name" value="KELCH-LIKE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB64846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="596" mass="67336" checksum="5C85541BB490AFDA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NW73</accession>
    <name>A0A401NW73_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0013420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006844">
        <property type="protein sequence ID" value="GCB65128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NW73"/>
    <dbReference type="STRING" id="75743.A0A401NW73"/>
    <dbReference type="OMA" id="ENARTDY"/>
    <dbReference type="OrthoDB" id="2126778at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07661">
        <property type="entry name" value="BAR_ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000015">
        <property type="entry name" value="Islet cell autoantigen 1, 69kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF3">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="1">
        <location>
            <begin position="60"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="313" mass="36679" checksum="780B71E2E3DF63C6" modified="2019-05-08" version="1">MPIVRLRCLVMSGGYARDLYSRYVRNQDSSVVNKMQQRYWKTKQTFIKVTGKKEDEHVVASDADLDSKLEIFHSIQRTCMELLKVIEQYQKRICFLSQEENELGRFLRSQGSQDKTRAGKMMQASGKALCFSSQQRLALRSPLCRLYQEVETFRYRAISDTWLTVSRMEQSRTEYRGALLWMKDISQELDPDMYKHLEKFRKVQGQVRHTKIHFDKLKNDVCQKVDLLGASRCNLLSHILATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFAMLKELRLHWSQAVMTLLSQHALLVCDALMGQELSQKAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NWL8</accession>
    <name>A0A401NWL8_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0004748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001426">
        <property type="protein sequence ID" value="GCB65260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NWL8"/>
    <dbReference type="OMA" id="WHNSAHE"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB65260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="158" mass="18473" checksum="CC5F250992FAE52C" modified="2019-05-08" version="1">MSPRSFSSDHSHNPQEETLNETSDAKKDTDTNNFENDSNYPHGTVIECNKNHKNRNRNKNNSSNNKSYKNNNKNNNKQHNKNDNCNKHDTNNKTNNEDYYNRNNTHNKNNNGNNKDRNNRNNKNNNNETTTSTTWHNSAHEGHCNSSKQWQECKHNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NX76</accession>
    <name>A0A401NX76_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-related protein Rab-5C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0011875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005565">
        <property type="protein sequence ID" value="GCB65454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NX76"/>
    <dbReference type="STRING" id="75743.A0A401NX76"/>
    <dbReference type="OMA" id="TAGHECY"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003486">
        <property type="entry name" value="Major sperm protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB65454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20454" checksum="241E36D9961FA6FB" modified="2019-05-08" version="1">MANRGGAARPNGPAAANKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNDADLANKRAVEFQEAQSYADDNSLLFMETSAKTSINVNEIFLAIAKKLPKNEPQNTGPNSGRSRGVDLHEPTQQTKSQCCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NXC4</accession>
    <name>A0A401NXC4_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">scyTo_0000428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000082">
        <property type="protein sequence ID" value="GCB65523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NXC4"/>
    <dbReference type="STRING" id="75743.A0A401NXC4"/>
    <dbReference type="OMA" id="CLQVEIN"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="6">
        <location>
            <begin position="279"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GCB65523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="404" mass="43468" checksum="E6ED1B3CF18A2999" modified="2019-05-08" version="1">MAASVTLRATRALRTGAGRPALCPRQMVQIIPVRWLNLQEYQSKKIMADHGVTVQRFFVADNSQDALKAAKRLKAKEIVLKAQILAGGRGKGSFTSGLKGGVHLTKNPDEVGQLAKQMLGYNLITKQTAKEGVKVNKVMVAEALDIARETYLAILMDRACNGPVIVGSPQGGMDIEEVAATKPELIFKEVIDIFEGVRGDQALRMAANIGFKGPLQQQVLDGGLVVCFDAKINFDDNAQFRQKEIFSQDDISESDPFESEAAKYDLKYIGMDGNIACFVNGAGLAMATCDIIDLHGGKPANFLDLGGGVQENQVYQAFKLLTADPRVEAILVNIFGGIVNCAIIAHGITKASRELKLKVPLVVRLEGTNVNEAKRILNESGLPITSASNLEDAAKKAVASMASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NYT5</accession>
    <name>A0A401NYT5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0011946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005619">
        <property type="protein sequence ID" value="GCB66031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NYT5"/>
    <dbReference type="STRING" id="75743.A0A401NYT5"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB66031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="56056" checksum="FE680B1F2578F8A2" modified="2019-05-08" version="1">MLAFNTDKRLREITDFSRQSLEESIEGSVEVMSASLLDAKAFNKKEYKSLRILAESNRTEDASRIIFDTVLEKGSREERIIWTILFQLQNVIPKLRESLVMTQQRFPDAGMQVKENSDTKFLQILATWTDIELHRATTFYRLTIEQSIEEFVEKVSHSVLNATAFTKTDYKKIGMLTDRNRTNDASQAFLDILLIKGAHSERMLWQELFQLQNIKPKLKAAFVELQTEERGTFMNAQEEKCDFCQPEGKRDTSVKQRGTFMNAQEEKCDFCQPEEKRDTSVKQTSDAIILQMVARYTDNQLRRFTDFYRHTLEETIEDYVEEVRRHLSRANVFTKIDQKRITKIAESHSSNEVSKAIVDIMLEKKAPGERVMWNTLFQLQKVKPRIKATLSKIKNIGISNTTVLLMLPTYTDAELRKLTYDHRFKLVKSIEKHVEAVSRSLLDACVFTEREHKDYKEDAPLETLRPHPVLPSGLAARCFANGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZ24</accession>
    <name>A0A401NZ24_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">scyTo_0011954</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Postsynaptic density membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the AB hydrolase superfamily. ABHD17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="BFAA01005628">
        <property type="protein sequence ID" value="GCB66105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZ24"/>
    <dbReference type="STRING" id="75743.A0A401NZ24"/>
    <dbReference type="OMA" id="YIRCVPG"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000008">
        <property type="entry name" value="Alpha/beta hydrolase domain-containing protein 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF52">
        <property type="entry name" value="ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="14">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GCB66105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="203" mass="22752" checksum="B1C0B3E8C2E22C1E" modified="2019-05-08" version="1" fragment="single">VARFTLLFSHGNAVDLGQMSSFYIGLGTRINCNIFSYDYSGYGVSNGKPSEKNLYADIDAAWQALRTRYGISPENIILYGQSIGTVPTVDLASRYECAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALYERCMKAVEPLWVEGAGHNDIELYSQYLERLRKFISYELVNVQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401NZS4</accession>
    <name>A0A401NZS4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">scyTo_0007871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01002931">
        <property type="protein sequence ID" value="GCB66388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401NZS4"/>
    <dbReference type="STRING" id="75743.A0A401NZS4"/>
    <dbReference type="OMA" id="STQHECL"/>
    <dbReference type="OrthoDB" id="5980998at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046325">
        <property type="term" value="P:negative regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039112">
        <property type="entry name" value="PID1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16265">
        <property type="entry name" value="PTB-CONTAINING, CUBILIN AND LRP1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16265:SF1">
        <property type="entry name" value="PTB-CONTAINING, CUBILIN AND LRP1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="130"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GCB66388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="216" mass="24788" checksum="9B7BFF69FAF41B76" modified="2019-05-08" version="1">MWQPASERLQHFQTMLKTKLNVLTLRKEPLPTVIFHEPEAIELSPTAPLKNDQPYTERKVRYLGKVVMRGTQFTSGCTERSVIELWEKHILDYEDITSANAILEIRPFQVRLHHLDAKREATVQMDTFQVARIAYCTADHNVSTNIFAWLYREINDDLSYQIDCHAVECGSKLEAKKLAHAMMEAFKKTFTRMKSDGRIHNSSSSEEAESAASDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0T4</accession>
    <name>A0A401P0T4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">scyTo_2000071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001523">
        <property type="protein sequence ID" value="GCB66745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P0T4"/>
    <dbReference type="STRING" id="75743.A0A401P0T4"/>
    <dbReference type="OMA" id="QNGHDYQ"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000055">
        <property type="entry name" value="Homeobox protein Hox-A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GCB66745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="252" mass="28533" checksum="6522D51E52CE8D78" modified="2019-05-08" version="1">MSSYFLNSFSGRYQNGHDYQLQSYGNAASVGEHFREPTVLSARYGYDYTGIDLSMTRSNSNLCGDSERSANYLQTASNTFQSSSGMKMKSPDPAFCSTSLISPSDRAIKAGATITESSHSYSGDQDTSPLNDGHPKGTNSPKPESGQLDKDPARQLQIYPWMKKMHLNQEGLSGLEGKRTRTAYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKDNKLKSINVSPPGGGCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P0X6</accession>
    <name>A0A401P0X6_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="4">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37" type="ORF">scyTo_0007938</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Membrane</location>
            <topology evidence="31">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="31">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="37">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAA01002965">
        <property type="protein sequence ID" value="GCB66786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="75743.A0A401P0X6"/>
    <dbReference type="OMA" id="TCVFERR"/>
    <dbReference type="OrthoDB" id="9873386at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005021">
        <property type="term" value="F:vascular endothelial growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045446">
        <property type="term" value="P:endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000077">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000532">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000041">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000143">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000247">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000411">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041348">
        <property type="entry name" value="VEGFR-2_TMD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055229">
        <property type="entry name" value="VEGFR1-3_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055238">
        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009136">
        <property type="entry name" value="VEGFR2_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF45">
        <property type="entry name" value="VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22971">
        <property type="entry name" value="Ig_VEGFR-1-like_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21339">
        <property type="entry name" value="VEGFR-1-like_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17988">
        <property type="entry name" value="VEGFR-2_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22854">
        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01832">
        <property type="entry name" value="VEGFRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01834">
        <property type="entry name" value="VEGFRECEPTR2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="17 28 30" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-0221">Differentiation</keyword>
    <keyword evidence="21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="25 31" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="29" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="29" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 28 30" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22 31" id="KW-0675">Receptor</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 34" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 31 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="20" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="34">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019479116" description="receptor protein-tyrosine kinase" evidence="34">
        <location>
            <begin position="21"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="218"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="319"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="417"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="562"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="669"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="35">
        <location>
            <begin position="836"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1287"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="27">
        <location>
            <position position="1031"/>
        </location>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <begin position="843"/>
            <end position="850"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28 30">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="1035"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="1036"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="1049"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
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    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU000311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GCB66786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="1347" mass="152160" checksum="54E435E9E5955803" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P1I7</accession>
    <name>A0A401P1I7_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein heavy chain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0010178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01004338">
        <property type="protein sequence ID" value="GCB66999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:dynein intermediate chain binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHC"/>
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        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF8">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB66999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="102" mass="11641" checksum="E125EF6538A97387" modified="2019-05-08" version="1" fragment="single">VYVRGLFIDGARWDRNLKKLAESKPKILYDTMPVMWLKPCKRSEISPHPVYIAPVYKTSERRGTLSTTGHSTNFVIAMRIPTDQPSEHWIGRGVALLCQLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4K8</accession>
    <name>A0A401P4K8_SCYTO</name>
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        <recommendedName>
            <fullName evidence="4">28S ribosomal protein S14, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">scyTo_0013777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01007179">
        <property type="protein sequence ID" value="GCB68071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4K8"/>
    <dbReference type="STRING" id="75743.A0A401P4K8"/>
    <dbReference type="OMA" id="ISTTWRM"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GCB68071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="125" mass="14993" checksum="4CB619AEDA8B2E8E" modified="2019-05-08" version="1">MMQHSDDYELLSWIPGGNGGPTRNYYVDWRMLRDVKRRKMAFEFADERRRLNAIRKNTILPKELQEVADQEIASLPRDSCPVRIRNRCVLTSRPRGVKRRWRLSRIVFRHLADHNQMSGIQRAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P4W5</accession>
    <name>A0A401P4W5_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0005261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001620">
        <property type="protein sequence ID" value="GCB68174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P4W5"/>
    <dbReference type="STRING" id="75743.A0A401P4W5"/>
    <dbReference type="OMA" id="CDEFGEC"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF25">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37377" checksum="8F8CB43FF92864B7" modified="2019-05-08" version="1">MEPRKIEWIGSPCGSHGPYTFYRAFSLPEPGSSGKGKALTARLGHFFFVRCQPHEPECIAELQLLWEDRSHQQLLASTRLYFSPEDTPQGRSLHHGQDEVIAVSKRIIIRLQDLAKWVCTESSQWTTNTKEAKSSTIHLDSSVREENPKLNVRLPAHCCHTSNNVENESENSGFKDDRPRVKILSYPQYCRYRAIRKRIQKVSADSVSEAQLLALGGILLVNQNTKILYCRETFEHPTLGDNKSICDEFAPRVLTRTSAGRVVRTRLQITTQPRSLTLLHLQLTGDTKKTARPLKNDTLLSGSGVQQEVEKKDTSGRRSLMPMEQHCSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5F5</accession>
    <name>A0A401P5F5_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0012266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005870">
        <property type="protein sequence ID" value="GCB68333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5F5"/>
    <dbReference type="OMA" id="YXTNELV"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB68333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="74" mass="8437" checksum="C8FDCA99121CD40F" modified="2019-05-08" version="1">MRSINDYESDALKIIHQAHGAKTNDLVVSLDNDDQLMLKEASTLKEAGVAHETEVAFFKREDYETFKKNPVAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P5K3</accession>
    <name>A0A401P5K3_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0000874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01000180">
        <property type="protein sequence ID" value="GCB68397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P5K3"/>
    <dbReference type="STRING" id="75743.A0A401P5K3"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB68397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="84" mass="9489" checksum="7B1DBB36A45B025E" modified="2019-05-08" version="1">MYAVFGAFLFEQLERTNESAKNYDNFLNELWEIANKTHEGNETEAGKKYFKDACVCQYMCVSVRVCVSIAHCLSVCVSVCVSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P6Z1</accession>
    <name>A0A401P6Z1_SCYTO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mab-21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01005932">
        <property type="protein sequence ID" value="GCB68885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P6Z1"/>
    <dbReference type="STRING" id="75743.A0A401P6Z1"/>
    <dbReference type="OMA" id="CWRLTRE"/>
    <dbReference type="OrthoDB" id="5961151at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000002">
        <property type="entry name" value="protein mab-21-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.90:FF:000001">
        <property type="entry name" value="protein mab-21-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF37">
        <property type="entry name" value="PROTEIN MAB-21-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="8">
        <location>
            <begin position="246"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB68885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="359" mass="40922" checksum="3E35C96CE3781184" modified="2019-05-08" version="1">MIAAQAKLVYQLNKYYNERCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLSEIETRFEGLEVIAPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWPGPNRVAEVKAEGFNLLSKECYSLTGKQSSAESDAWVLQFGEAENRLLMGGCRKKCLSVLKTLRDRHLELPGQPLNNYHMKTLLLYECEKHPRETDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALESAAKQTWRLAREILTNAKSLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P7V8</accession>
    <name>A0A401P7V8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">scyTo_0008352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003175">
        <property type="protein sequence ID" value="GCB69227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P7V8"/>
    <dbReference type="STRING" id="75743.A0A401P7V8"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="198"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GCB69227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="383" mass="42380" checksum="91B6898308E93936" modified="2019-05-08" version="1" fragment="single">RFDFRKANDKVAAVCESAQNSVFSSSVEDVSVIVTHVETPSNFFCQQLSSRYEFQQLQKVVADYCNNITPIPSFRPAVGEICCAQFTGVKPISDTWSLDAILRMKSLVLNKFLKSRTVEKKENKLVVQLKDETQIPIININEKLISEGLATKMAGEQIISTLESSKTRECGGNFKKLYLLSTELAEHCSSQPESCLFNPEVGDACCARLAGDNIWYRAIVLNCSDLTVKVICADNGIVETVPLERVKCITPELLDPPFQVGKFALSDVEPTFDVWTPAASNLLKTLLLDKNILATIREFDGNIHTVDLIGHVEGAAIKISDKLVLEGLAKYPDQRITQKECNKCWSSQIVNFICPVTDSCGTALLTFGTFILYSHSAFDLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401P9X4</accession>
    <name>A0A401P9X4_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">scyTo_0012519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01006067">
        <property type="protein sequence ID" value="GCB69951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401P9X4"/>
    <dbReference type="STRING" id="75743.A0A401P9X4"/>
    <dbReference type="OMA" id="DISICNG"/>
    <dbReference type="OrthoDB" id="6755574at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GCB69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="166" mass="18786" checksum="B59138FA6514B83A" modified="2019-05-08" version="1">MVPINQSIFCVNLGQLARDAVLNKNVSTLELPKSTKDVKAGTKCSVAGWGWTNLKVPKLSDTLREANIIIIDRRKCNSRKYYHYDPFITKDMLCAGDKKARRDSCNGDSGGPLMCKTSMFRKKYIYRGIVSAGDECAKRKKPGIYTRLSEKFLKWINNITKVKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PBK2</accession>
    <name>A0A401PBK2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FAM78B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">scyTo_0008597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003327">
        <property type="protein sequence ID" value="GCB70500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PBK2"/>
    <dbReference type="STRING" id="75743.A0A401PBK2"/>
    <dbReference type="OMA" id="MPPIHRN"/>
    <dbReference type="OrthoDB" id="9971204at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029638">
        <property type="entry name" value="FAM78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31655">
        <property type="entry name" value="PROTEIN FAM78A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31655:SF0">
        <property type="entry name" value="PROTEIN FAM78B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GCB70500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29775" checksum="038020CF809F43BC" modified="2019-05-08" version="1">MGCIQSITCKSRIRRENIVVYDVSATIDQCPTLIEENSPIVLRYKTPYFKASARVVMPPVPRNETWVVGWIQACNQMEFFNTYSDLGMSSWELPDLREGRVKAISDSDGVSYPWYGNTTETVTLIGPINKASRFAVSMNDNFYPSVTWAVPVSESNVPQLTRIKRDQSFTTWLVAMNTISKEKILLQTIKWRMRVDIEVDPSNPLGYRSKLVGRTQQEQPRILTRMEPIPPNSLVKPNANDAQVLMWRPKRGLPLVVIPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PC16</accession>
    <name>A0A401PC16_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">scyTo_0008637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003353">
        <property type="protein sequence ID" value="GCB70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PC16"/>
    <dbReference type="STRING" id="75743.A0A401PC16"/>
    <dbReference type="OMA" id="SWIAVEC"/>
    <dbReference type="OrthoDB" id="8921018at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF228">
        <property type="entry name" value="OTOGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GCB70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="230" mass="25989" checksum="8A3FC70AB6DDEFD2" modified="2019-05-08" version="1">METAITRLLMEFFMILLALARFTWLSLGTLRLSIIAENIDCYGSGAFCRKALSVSVGHAFLVFDDDSGNMSPSSVTDLQQIIHIWKAGIFTVIHFPTEEITILWDRRTTIHVQIGPKWQGKLSGLCGNFDMKTANEMRTPDHIESPNPQEFGNSWIAVECTNSPDIRNPCNMNPLREPFAKKECGILLSKVFEPCHPVVDVTWFYSNCLTDTCACNRGGDSYDCEYYNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDL8</accession>
    <name>A0A401PDL8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">scyTo_0008785</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003426">
        <property type="protein sequence ID" value="GCB71202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDL8"/>
    <dbReference type="STRING" id="75743.A0A401PDL8"/>
    <dbReference type="OMA" id="MEGVMRD"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000047">
        <property type="entry name" value="protein phosphatase 1 regulatory subunit 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055106">
        <property type="entry name" value="ELFN_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF204">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22986">
        <property type="entry name" value="Fn3_ELFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019079530" description="LRRCT domain-containing protein" evidence="14">
        <location>
            <begin position="22"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="15">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GCB71202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="778" mass="87410" checksum="75923E898C428F24" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDM2</accession>
    <name>A0A401PDM2_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0008787</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01003430">
        <property type="protein sequence ID" value="GCB71228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDM2"/>
    <dbReference type="STRING" id="75743.A0A401PDM2"/>
    <dbReference type="OMA" id="XDGRERE"/>
    <dbReference type="OrthoDB" id="1746725at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.950.10:FF:000001">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF18">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HP" evidence="9">
        <location>
            <begin position="407"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GCB71228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288216"/>
        </source>
    </evidence>
    <sequence length="475" mass="54150" checksum="35669F70857D48A0" modified="2019-05-08" version="1" fragment="single">ISRPGLTRAGDKHYHPSCARCSKCNQMFTEGEEMYLQGSTVWHPDCKKSTRAEEKQRPTRSSSESITSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPYFGATFEDRHERHSMAESQYARSDNGSLVQSEISPRTLSPTPSTEGYHDARDRMVHRSSSQGSINSPVYNRHCYTPTVARSPQHFHRPDQGTNIYRKPPIYKQYDAAAMAAQLKTGVEIIKSSKFPAAQAPDPDQTSEVETDYWPGPGTIGMDRRRGSEREEEDEEKLRRRQLQEEQLSKIQSGLGKLILKEEQEREKQARLASHTPSGDLQFRHRYDSAGNASLHASASKTASLPGYGRNGLHRPQSTDFTQYDSYSDVSEGVREPLPSQERTAQGARMDRGVSMPNMLEPKIYPYQVLSVTNRGRRKLPRDVDRTRLERHLTPEDFCKLFNMTIQDFDRLPLWKRNDLKKKSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401PDW8</accession>
    <name>A0A401PDW8_SCYTO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Syntaxin 6/10/61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">scyTo_0005904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Scyliorhinus torazame</name>
        <name type="common">Cloudy catshark</name>
        <name type="synonym">Catulus torazame</name>
        <dbReference type="NCBI Taxonomy" id="75743"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Chondrichthyes</taxon>
            <taxon>Elasmobranchii</taxon>
            <taxon>Galeomorphii</taxon>
            <taxon>Galeoidea</taxon>
            <taxon>Carcharhiniformes</taxon>
            <taxon>Scyliorhinidae</taxon>
            <taxon>Scyliorhinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Nat. Ecol. Evol." volume="2" first="1761" last="1771">
            <title>Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.</title>
            <authorList>
                <person name="Hara Y"/>
                <person name="Yamaguchi K"/>
                <person name="Onimaru K"/>
                <person name="Kadota M"/>
                <person name="Koyanagi M"/>
                <person name="Keeley SD"/>
                <person name="Tatsumi K"/>
                <person name="Tanaka K"/>
                <person name="Motone F"/>
                <person name="Kageyama Y"/>
                <person name="Nozu R"/>
                <person name="Adachi N"/>
                <person name="Nishimura O"/>
                <person name="Nakagawa R"/>
                <person name="Tanegashima C"/>
                <person name="Kiyatake I"/>
                <person name="Matsumoto R"/>
                <person name="Murakumo K"/>
                <person name="Nishida K"/>
                <person name="Terakita A"/>
                <person name="Kuratani S"/>
                <person name="Sato K"/>
                <person name="Hyodo S Kuraku.S."/>
            </authorList>
            <dbReference type="PubMed" id="30297745"/>
            <dbReference type="DOI" id=".1038/s41559-018-0673-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAA01001912">
        <property type="protein sequence ID" value="GCB71316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401PDW8"/>
    <dbReference type="STRING" id="75743.A0A401PDW8"/>
    <dbReference type="OMA" id="WATNELW"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000288216">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Syntaxin 6/10/61 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09177"/>
      